Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/2166

TDMS Study 05143-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                        CORN OIL / CORN OIL


NTP Experiment-Test: 05143-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/17/94
Route: GAVAGE                                                                                                     Time: 18:44:16




       Facility:  TSI Mason Research

       Chemical CAS #:  8001-30-7

       Lock Date:  11/08/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05143-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:16  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           14            9            6            4                        
    Natural Death                                      8            4            8            6            6                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           32           33           38           40                        
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    50           50           50           50           50                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (48)         (50)         (50)         (50)                      
      Hyperkeratosis                                                             1 (2%)                                             
   Intestine Large, Colon                             (49)         (49)         (46)         (49)         (48)                      
      Cyst                                                                                                 1 (2%)                   
   Intestine Large, Cecum                             (46)         (49)         (45)         (48)         (46)                      
      Erosion                                          3 (7%)       1 (2%)                                                          
      Inflammation, Granulomatous                                                1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Ileum                             (46)         (49)         (45)         (48)         (47)                      
      Erosion                                                       1 (2%)                                                          
      Fibrosis                                                                                1 (2%)                                
      Pigmentation                                                  1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)         (50)                      
      Angiectasis                                                   2 (4%)       1 (2%)                                             
      Basophilic Focus                                33 (66%)     33 (66%)     38 (76%)     37 (74%)     46 (92%)                  
      Clear Cell Focus                                11 (22%)     16 (32%)     27 (54%)     24 (48%)     21 (42%)                  
      Congestion                                       1 (2%)                                                                       
      Degeneration, Cystic                                                       2 (4%)                                             
      Eosinophilic Focus                               9 (18%)      3 (6%)       4 (8%)       4 (8%)       6 (12%)                  
      Fatty Change, Diffuse                            3 (6%)       2 (4%)      19 (38%)     27 (54%)     33 (66%)                  
      Fatty Change, Focal                              3 (6%)       4 (8%)                                 3 (6%)                   
      Hematocyst                                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       4 (8%)       6 (12%)      4 (8%)       8 (16%)      5 (10%)                  
      Infarct                                          1 (2%)                                                                       
      Mixed Cell Focus                                 5 (10%)      5 (10%)      1 (2%)       8 (16%)      8 (16%)                  
      Necrosis                                         1 (2%)                                 1 (2%)                                
   Mesentery                                          (6)          (7)          (8)          (4)          (8)                       
      Fat, Hemorrhage                                                            1 (13%)                                            
      Fat, Inflammation, Chronic Active                1 (17%)      1 (14%)                                                         
      Fat, Mineralization                                                                                  2 (25%)                  
      Fat, Necrosis                                    2 (33%)      3 (43%)      5 (63%)      2 (50%)      7 (88%)                  
   Pancreas                                           (50)         (50)         (47)         (50)         (50)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05143-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:16  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Metaplasia                                                                                           1 (2%)                   
      Thrombosis                                                                 1 (2%)                                             
      Acinus, Atrophy                                 38 (76%)     40 (80%)     25 (53%)     32 (64%)     24 (48%)                  
      Acinus, Hyperplasia                              8 (16%)      5 (10%)     28 (60%)     28 (56%)     35 (70%)                  
      Acinus, Hypertrophy, Focal                                                                           1 (2%)                   
      Artery, Hyperplasia                                                        1 (2%)                                             
      Artery, Inflammation, Chronic Active             2 (4%)       2 (4%)       5 (11%)      1 (2%)       1 (2%)                   
   Pharynx                                            (1)                       (1)                                                 
      Hyperkeratosis                                   1 (100%)                                                                     
      Inflammation, Chronic Active                     1 (100%)                                                                     
   Salivary Glands                                    (50)         (50)         (50)         (50)         (49)                      
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Duct, Metaplasia, Squamous                       6 (12%)      6 (12%)     11 (22%)      8 (16%)      8 (16%)                  
   Stomach, Forestomach                               (50)         (49)         (50)         (50)         (50)                      
      Fibrosis                                                                   1 (2%)                                             
      Hyperkeratosis                                   3 (6%)       1 (2%)       1 (2%)       2 (4%)       5 (10%)                  
      Hyperplasia, Basal Cell                          4 (8%)       4 (8%)       2 (4%)       1 (2%)       8 (16%)                  
      Ulcer                                            2 (4%)                    3 (6%)       1 (2%)       3 (6%)                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (48)                      
      Erosion                                         10 (20%)      4 (8%)       2 (4%)       2 (4%)       2 (4%)                   
      Hyperplasia                                                   3 (6%)                                                          
      Mineralization                                                             1 (2%)                    1 (2%)                   
   Tongue                                                          (3)          (2)                       (3)                       
      Hemorrhage                                                                 2 (100%)                                           
      Hyperplasia, Squamous                                                                                1 (33%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (50)                      
      Cardiomyopathy                                  47 (94%)     42 (84%)     46 (92%)     47 (94%)     45 (90%)                  
      Pigmentation                                                               1 (2%)                                             
      Thrombosis                                       3 (6%)       1 (2%)       1 (2%)                    1 (2%)                   
      Artery, Inflammation, Chronic Active                          1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (50)                      
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Hypertrophy                                      2 (4%)       3 (6%)       4 (8%)                                             
   Adrenal Medulla                                    (49)         (49)         (50)         (50)         (50)                      
      Cyst                                                                                                 1 (2%)                   
      Hyperplasia                                      8 (16%)      7 (14%)     12 (24%)     11 (22%)      9 (18%)                  
   Islets, Pancreatic                                 (50)         (49)         (47)         (50)         (50)                      
      Hyperplasia                                      1 (2%)       2 (4%)       4 (9%)       2 (4%)       3 (6%)                   
   Parathyroid Gland                                  (44)         (47)         (49)         (40)         (45)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05143-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:16  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (3%)                                
   Pituitary Gland                                    (50)         (49)         (50)         (49)         (50)                      
      Pars Distalis, Angiectasis                       5 (10%)      6 (12%)      5 (10%)      4 (8%)       6 (12%)                  
      Pars Distalis, Cyst                                           1 (2%)       3 (6%)       1 (2%)                                
      Pars Distalis, Hyperplasia                       9 (18%)      9 (18%)     13 (26%)      9 (18%)      9 (18%)                  
      Pars Intermedia, Hyperplasia                                                                         1 (2%)                   
      Rathke's Cleft, Cyst                                          1 (2%)                                                          
   Thyroid Gland                                      (50)         (49)         (49)         (49)         (49)                      
      Bilateral, C-Cell, Hyperplasia                                             1 (2%)       1 (2%)                                
      C-Cell, Hyperplasia                              3 (6%)       9 (18%)      8 (16%)      7 (14%)     11 (22%)                  
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                                               3 (6%)                    2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)         (48)                      
      Spermatocele                                                  1 (2%)                                                          
   Preputial Gland                                    (50)         (50)         (50)         (50)         (48)                      
      Abscess                                          3 (6%)       4 (8%)       4 (8%)       5 (10%)      7 (15%)                  
      Hyperplasia, Squamous                                                      1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)                                             
   Prostate                                           (50)         (49)         (50)         (50)         (48)                      
      Hyperplasia                                      2 (4%)       4 (8%)       6 (12%)      7 (14%)      4 (8%)                   
      Inflammation, Acute                                                                                  1 (2%)                   
      Inflammation, Chronic Active                     2 (4%)       2 (4%)       3 (6%)                                             
   Testes                                             (50)         (50)         (50)         (50)         (49)                      
      Interstitial Cell, Hyperplasia                                4 (8%)       3 (6%)       4 (8%)       4 (8%)                   
      Seminiferous Tubule, Atrophy                     7 (14%)      4 (8%)       2 (4%)       4 (8%)       6 (12%)                  
      Seminiferous Tubule, Mineralization                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
      Depletion Cellular                               1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
   Lymph Node                                         (28)         (22)         (15)         (13)         (8)                       
      Lumbar, Pigmentation                                          1 (5%)                                                          
      Mediastinal, Angiectasis                         4 (14%)      1 (5%)       3 (20%)      5 (38%)      1 (13%)                  
      Mediastinal, Ectasia                             1 (4%)                                                                       
      Mediastinal, Infiltration Cellular, Mast Cell    1 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05143-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:16  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Pigmentation                                                  4 (27%)      1 (8%)       2 (25%)                  
      Pancreatic, Angiectasis                          1 (4%)                                 1 (8%)                                
      Pancreatic, Ectasia                              3 (11%)                   2 (13%)                                            
      Pancreatic, Infiltration Cellular, Histiocyte    2 (7%)                                              2 (25%)                  
      Pancreatic, Pigmentation                                                   1 (7%)                    1 (13%)                  
      Renal, Pigmentation                                           1 (5%)                                                          
   Lymph Node, Mandibular                             (50)         (50)         (49)         (50)         (48)                      
      Angiectasis                                                                                          1 (2%)                   
      Necrosis                                                                   1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)         (49)                      
      Angiectasis                                      1 (2%)                                 1 (2%)                                
      Ectasia                                          2 (4%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
   Spleen                                             (49)         (50)         (49)         (50)         (49)                      
      Angiectasis                                      2 (4%)                                              1 (2%)                   
      Fibrosis                                        12 (24%)      8 (16%)      9 (18%)      3 (6%)       4 (8%)                   
      Hematopoietic Cell Proliferation                 8 (16%)      6 (12%)      3 (6%)       5 (10%)      5 (10%)                  
      Infarct                                          2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Infiltration Cellular, Lipocyte                                                                      1 (2%)                   
      Metaplasia                                                                                           1 (2%)                   
      Pigmentation                                                               2 (4%)       1 (2%)       1 (2%)                   
      Capsule, Fibrosis                                                          1 (2%)                                             
      Capsule, Hemorrhage                                                                     1 (2%)                                
   Thymus                                             (48)         (48)         (45)         (45)         (46)                      
      Cyst                                                          1 (2%)                                                          
      Epithelial Cell, Hyperplasia                    10 (21%)      7 (15%)      5 (11%)      5 (11%)      9 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (31)         (42)         (39)         (39)         (40)                      
      Galactocele                                                                                          2 (5%)                   
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Cyst Epithelial Inclusion                                                  4 (8%)       2 (4%)       2 (4%)                   
      Developmental Malformation                                                 1 (2%)                                             
      Erosion                                                       1 (2%)       1 (2%)                                             
      Fibrosis                                                                                1 (2%)                                
      Hemorrhage                                                                                           1 (2%)                   
      Hyperkeratosis                                                                                       2 (4%)                   
      Inflammation, Acute                                                                                  1 (2%)                   
      Mineralization                                                             1 (2%)                                             
      Ulcer                                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05143-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:16  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Hyperostosis                                                               2 (4%)                                             
   Skeletal Muscle                                    (50)         (50)         (50)         (50)         (50)                      
      Atrophy                                          5 (10%)      3 (6%)       8 (16%)      5 (10%)      2 (4%)                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)         (50)                      
      Compression                                      1 (2%)                    1 (2%)                                             
   Spinal Cord                                                                  (1)          (1)          (1)                       
      Hemorrhage                                                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (49)         (50)         (49)         (49)                      
      Edema                                            1 (2%)                    1 (2%)       2 (4%)       1 (2%)                   
      Foreign Body                                                               1 (2%)                                             
      Fungus                                           1 (2%)                                                                       
      Hemorrhage                                                                 2 (4%)                    1 (2%)                   
      Infarct                                          1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                2 (4%)       5 (10%)                   1 (2%)       2 (4%)                   
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)       1 (2%)                                             
      Metaplasia, Osseous                                           1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)       1 (2%)       1 (2%)       2 (4%)                   
   Nose                                               (50)         (50)         (50)         (49)         (49)                      
      Fungus                                          13 (26%)     12 (24%)     12 (24%)     18 (37%)     15 (31%)                  
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Acute                             16 (32%)     14 (28%)     17 (34%)     21 (43%)     21 (43%)                  
      Metaplasia, Cartilagenous                                                               1 (2%)                                
      Respiratory Epithelium, Hyperkeratosis                                     3 (6%)       1 (2%)                                
      Respiratory Epithelium, Metaplasia, Squamous     7 (14%)      8 (16%)      2 (4%)       7 (14%)      8 (16%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (3)          (2)          (3)          (2)                       
      Synechia                                                      1 (33%)                   1 (33%)      2 (100%)                 
      Lens, Cataract                                                2 (67%)                   2 (67%)                               
      Retina, Atrophy                                  1 (100%)     1 (33%)                   1 (33%)      2 (100%)                 
      Sclera, Mineralization                                                     1 (50%)                                            
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05143-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        CORN OIL / CORN OIL                                    Date: 09/17/94  
Route: GAVAGE                                                                                                     Time: 18:44:16  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 ML/KG      10           2.5          5.0          10.0                         
                                                                ML/KG         ML/KG       ML/KG        ML/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (48)         (50)         (49)                      
      Degeneration                                     1 (2%)                                                                       
      Hydronephrosis                                                             1 (2%)                                             
      Infarct                                          1 (2%)                                                                       
      Nephropathy                                     47 (94%)     45 (92%)     43 (90%)     45 (90%)     40 (82%)                  
      Cortex, Mineralization                                        1 (2%)                                 2 (4%)                   
      Cortex, Necrosis                                              1 (2%)                                                          
      Papilla, Mineralization                                                                              2 (4%)                   
      Renal Tubule, Pigmentation                                                                           1 (2%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------