TDMS Study 05143-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
CORN OIL / CORN OIL
NTP Experiment-Test: 05143-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/17/94
Route: GAVAGE Time: 18:44:17
Facility: TSI Mason Research
Chemical CAS #: 8001-30-7
Lock Date: 11/08/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05143-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CORN OIL / CORN OIL Date: 09/17/94
Route: GAVAGE Time: 18:44:17
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FISCHER 344 RATS MALE 0 ML/KG 10 2.5 5.0 10.0
ML/KG ML/KG ML/KG ML/KG
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DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50 50
Early Deaths
Moribund Sacrifice 16 14 9 6 4
Natural Death 8 4 8 6 6
Survivors
Terminal Sacrifice 25 32 33 38 40
Natural Death 1
Animals Examined Microscopically 50 50 50 50 50
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ALIMENTARY SYSTEM
Intestine Large, Colon (49) (49) (46) (49) (48)
Intestine Large, Cecum (46) (49) (45) (48) (46)
Intestine Small, Duodenum (48) (49) (47) (50) (48)
Intestine Small, Jejunum (44) (49) (45) (48) (47)
Muscularis, Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (46) (49) (45) (48) (47)
Adenocarcinoma 1 (2%)
Liver (50) (50) (50) (50) (50)
Hepatocellular Adenoma 4 (8%) 2 (4%)
Hepatocellular Adenoma, Multiple 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (6) (7) (8) (4) (8)
Pancreas (50) (50) (47) (50) (50)
Mixed Tumor Benign 1 (2%)
Acinus, Adenoma 1 (2%) 1 (2%) 6 (13%) 3 (6%) 11 (22%)
Acinus, Adenoma, Multiple 2 (4%) 7 (14%) 12 (24%)
Acinus, Carcinoma 1 (2%)
Pharynx (1) (1)
Palate, Squamous Cell Papilloma 1 (100%)
Salivary Glands (50) (50) (50) (50) (49)
Stomach, Forestomach (50) (49) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50) (50) (48)
Leiomyosarcoma 1 (2%)
Tongue (3) (2) (3)
Squamous Cell Papilloma 1 (33%)
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NTP Experiment-Test: 05143-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CORN OIL / CORN OIL Date: 09/17/94
Route: GAVAGE Time: 18:44:17
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 10 2.5 5.0 10.0
ML/KG ML/KG ML/KG ML/KG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50) (50)
Adrenal Medulla (49) (49) (50) (50) (50)
Ganglioneuroma 1 (2%)
Pheochromocytoma Malignant 2 (4%) 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 18 (37%) 13 (27%) 15 (30%) 3 (6%) 7 (14%)
Bilateral, Pheochromocytoma Malignant 1 (2%)
Bilateral, Pheochromocytoma Benign 2 (4%) 2 (4%) 4 (8%) 1 (2%)
Islets, Pancreatic (50) (49) (47) (50) (50)
Adenoma 9 (18%) 5 (10%) 3 (6%) 4 (8%) 7 (14%)
Parathyroid Gland (44) (47) (49) (40) (45)
Pituitary Gland (50) (49) (50) (49) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Pars Distalis, Adenoma 5 (10%) 6 (12%) 10 (20%) 6 (12%) 7 (14%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (49) (49) (49) (49)
Bilateral, C-Cell, Adenoma 1 (2%) 2 (4%)
C-Cell, Adenoma 4 (8%) 3 (6%) 5 (10%) 3 (6%) 8 (16%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Adenoma 2 (4%)
Follicular Cell, Carcinoma 1 (2%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ductus Deferens (1)
Epididymis (50) (50) (50) (50) (48)
Preputial Gland (50) (50) (50) (50) (48)
Adenoma 6 (12%) 8 (16%) 2 (4%) 3 (6%) 3 (6%)
Bilateral, Adenoma 1 (2%) 1 (2%)
Prostate (50) (49) (50) (50) (48)
Adenoma 2 (4%)
Seminal Vesicle (50) (49) (49) (50) (48)
Testes (50) (50) (50) (50) (49)
Bilateral, Interstitial Cell, Adenoma 40 (80%) 39 (78%) 43 (86%) 41 (82%) 39 (80%)
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NTP Experiment-Test: 05143-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CORN OIL / CORN OIL Date: 09/17/94
Route: GAVAGE Time: 18:44:17
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 10 2.5 5.0 10.0
ML/KG ML/KG ML/KG ML/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Interstitial Cell, Adenoma 8 (16%) 8 (16%) 3 (6%) 6 (12%) 9 (18%)
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HEMATOPOIETIC SYSTEM
Blood (8) (9) (4) (3)
Bone Marrow (50) (50) (50) (50) (50)
Lymph Node (28) (22) (15) (13) (8)
Lymph Node, Mandibular (50) (50) (49) (50) (48)
Lymph Node, Mesenteric (50) (50) (50) (50) (49)
Spleen (49) (50) (49) (50) (49)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (48) (48) (45) (45) (46)
Epithelial Cell, Thymoma Benign 1 (2%) 1 (2%)
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INTEGUMENTARY SYSTEM
Mammary Gland (31) (42) (39) (39) (40)
Fibroadenoma 4 (13%) 2 (5%) 1 (3%) 1 (3%) 3 (8%)
Skin (50) (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%) 1 (2%)
Squamous Cell Carcinoma 2 (4%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 5 (10%) 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 3 (6%) 1 (2%) 1 (2%) 5 (10%)
Subcutaneous Tissue, Hemangioma 1 (2%)
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MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (50) (50) (50) (50) (50)
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NERVOUS SYSTEM
Brain (50) (49) (50) (50) (50)
Spinal Cord (1) (1) (1)
Astrocytoma Malignant 1 (100%)
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NTP Experiment-Test: 05143-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CORN OIL / CORN OIL Date: 09/17/94
Route: GAVAGE Time: 18:44:17
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 10 2.5 5.0 10.0
ML/KG ML/KG ML/KG ML/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (49) (50) (49) (49)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Fibrosarcoma, Metastatic, Ear 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Mediastinum, Carcinoma, Metastatic, Zymbal's
Gland 1 (2%)
Nose (50) (50) (50) (49) (49)
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SPECIAL SENSES SYSTEM
Ear (2) (1) (2)
Fibrosarcoma 1 (50%)
Fibrous Histiocytoma 1 (50%)
Harderian Gland (1)
Carcinoma 1 (100%)
Zymbal's Gland (2) (1)
Adenoma 1 (50%)
Carcinoma 1 (50%) 1 (100%)
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URINARY SYSTEM
Kidney (50) (49) (48) (50) (49)
Urinary Bladder (49) (49) (47) (50) (48)
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SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Granulocytic 1 (2%)
Leukemia Mononuclear 27 (54%) 30 (60%) 16 (32%) 11 (22%) 7 (14%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 2 (4%) 1 (2%) 1 (2%) 1 (2%) 3 (6%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05143-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CORN OIL / CORN OIL Date: 09/17/94
Route: GAVAGE Time: 18:44:17
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 10 2.5 5.0 10.0
ML/KG ML/KG ML/KG ML/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 48 49 48 50
Total Primary Neoplasms 144 133 128 106 141
Total Animals with Benign Neoplasms 50 48 49 48 50
Total Benign Neoplasms 107 96 105 89 122
Total Animals with Malignant Neoplasms 33 31 21 16 16
Total Malignant Neoplasms 37 37 23 17 19
Total Animals with Metastatic Neoplasms 3 2 3 1 3
Total Metastatic Neoplasm 8 4 7 13 12
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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