TDMS Study 05143-01 Pathology Tables
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
Facility: TSI Mason Research
Chemical CAS #: 8001-30-7
Lock Date: 11/08/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 9| 3| 1| 3| 3| 0| 8| 1| 3| 8| 3| 3| 5| 3| 3| 0| 3| 1| 3| 3| 8| 1| 3|
| 5| 7| 1| 7| 0| 7| 7| 4| 5| 6| 7| 3| 7| 7| 1| 7| 5| 4| 7| 8| 7| 7| 7| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Erosion | 2 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X |
Congestion | 3 |
Eosinophilic Focus | X X X X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 1 1 |
Hematocyst | |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X |
Infarct | |
Mixed Cell Focus | X |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 2 2 3 2 2 1 2 3 2 2 3 2 2 1 2 1 |
Acinus, Hyperplasia | 1 2 1 2 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pharynx | |
Hyperkeratosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Duct, Metaplasia, Squamous | 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 2 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 3 2 2 2 2 2 2 2 1 2 3 2 2 2 3 2 2 3 2 3|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 9| 3| 1| 3| 3| 0| 8| 1| 3| 8| 3| 3| 5| 3| 3| 0| 3| 1| 3| 3| 8| 1| 3|
| 5| 7| 1| 7| 0| 7| 7| 4| 5| 6| 7| 3| 7| 7| 1| 7| 5| 4| 7| 8| 7| 7| 7| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + M M + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 3 2 |
Pars Distalis, Hyperplasia | 2 1 1 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 3 2 2 3 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Fibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Mediastinal, Angiectasis | 3|
Mediastinal, Ectasia | 3 |
Mediastinal, Infiltration Cellular, | |
Mast Cell | 3 |
Pancreatic, Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 9| 3| 1| 3| 3| 0| 8| 1| 3| 8| 3| 3| 5| 3| 3| 0| 3| 1| 3| 3| 8| 1| 3|
| 5| 7| 1| 7| 0| 7| 7| 4| 5| 6| 7| 3| 7| 7| 1| 7| 5| 4| 7| 8| 7| 7| 7| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Ectasia | 1 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Ectasia | 2 |
Infiltration Cellular, Mast Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Fibrosis | 2 3 2 2 2 |
Hematopoietic Cell Proliferation | 1 3 2 1 2 |
Infarct | 3 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + M M + + M + + M + + + M + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2|
Inflammation, Chronic Active | 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Fungus | |
Infarct | |
Infiltration Cellular, Histiocyte | 1 |
Alveolar Epithelium, Hyperplasia | 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 3 3 2 |
Hyperplasia | |
Inflammation, Acute | 2 2 2 2 2 2 3 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 9| 3| 1| 3| 3| 0| 8| 1| 3| 8| 3| 3| 5| 3| 3| 0| 3| 1| 3| 3| 8| 1| 3|
| 5| 7| 1| 7| 0| 7| 7| 4| 5| 6| 7| 3| 7| 7| 1| 7| 5| 4| 7| 8| 7| 7| 7| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Retina, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Infarct | |
Nephropathy | 3 3 2 3 3 3 2 2 2 3 1 2 2 1 3 1 2 3 2 3 2 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 7| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 9| 8| 7| 3| 0| 3| 2| 2| 3| 3| 9| 8| 1| 3| 3| 3| 3| 8| |
| 7| 7| 7| 7| 7| 9| 7| 7| 8| 8| 7| 4| 7| 3| 0| 7| 7| 7| 8| 5| 7| 7| 7| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 ML/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A A + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + A A + + + + + +| 46 |
Erosion | 3| 3 2.3|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + A + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + A A A + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + A + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X | 33 |
Clear Cell Focus | X X X X | 11 |
Congestion | | 1 3.0|
Eosinophilic Focus | X X X X X | 9 |
Fatty Change, Diffuse | 1 2 1 | 3 1.3|
Fatty Change, Focal | 2 | 3 1.3|
Hematocyst | X | 1 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 4 |
Infarct | 3 | 1 3.0|
Mixed Cell Focus | X X X X | 5 |
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Fat, Inflammation, Chronic Active | 3 | 1 3.0|
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 2 2 2 1 2 3 2 2 2 2 2 2 1 1 2 1 2 2| 38 1.9|
Acinus, Hyperplasia | 1 3 2 2 | 8 1.8|
Artery, Inflammation, Chronic Active | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
Duct, Metaplasia, Squamous | 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 1 | 3 1.7|
Hyperplasia, Basal Cell | 2 2 | 4 2.0|
Ulcer | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 7| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 9| 8| 7| 3| 0| 3| 2| 2| 3| 3| 9| 8| 1| 3| 3| 3| 3| 8| |
| 7| 7| 7| 7| 7| 9| 7| 7| 8| 8| 7| 4| 7| 3| 0| 7| 7| 7| 8| 5| 7| 7| 7| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 ML/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | 1 2 2 3 2 2 | 10 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 3 2 1 2 2 2 2 2 2 2 2 2 2 3 1 3 2 3 2| 47 2.1|
Thrombosis | 3 3 3| 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 1 1 2 | 8 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + M M + + + + + +| 44 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 | 5 2.2|
Pars Distalis, Hyperplasia | 1 2 1 2 | 9 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | | 3 1.3|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 3 2 1 | 3 2.0|
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
Inflammation, Chronic Active | 4 | 2 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Seminiferous Tubule, Atrophy | 3 | 7 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 7| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 9| 8| 7| 3| 0| 3| 2| 2| 3| 3| 9| 8| 1| 3| 3| 3| 3| 8| |
| 7| 7| 7| 7| 7| 9| 7| 7| 8| 8| 7| 4| 7| 3| 0| 7| 7| 7| 8| 5| 7| 7| 7| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 ML/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + | 8 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 2 | 1 2.0|
Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + +| 28 |
Mediastinal, Angiectasis | 2 1 2 | 4 2.0|
Mediastinal, Ectasia | | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Mast Cell | | 1 3.0|
Pancreatic, Angiectasis | 1 | 1 1.0|
Pancreatic, Ectasia | 2 2 | 3 1.7|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Ectasia | 1 | 2 1.5|
Infiltration Cellular, Mast Cell | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 2 2.0|
Fibrosis | 3 2 2 2 3 3 1 | 12 2.3|
Hematopoietic Cell Proliferation | 2 2 2 | 8 1.9|
Infarct | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Epithelial Cell, Hyperplasia | 2 2 2 3 2 | 10 2.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M + M + + M + + M + M + + M M M M M + + M M| 31 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 1 | 5 1.6|
Inflammation, Chronic Active | | 1 1.0|
Mineralization | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 7| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 9| 8| 7| 3| 0| 3| 2| 2| 3| 3| 9| 8| 1| 3| 3| 3| 3| 8| |
| 7| 7| 7| 7| 7| 9| 7| 7| 8| 8| 7| 4| 7| 3| 0| 7| 7| 7| 8| 5| 7| 7| 7| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 ML/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Compression | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2 | 1 2.0|
Fungus | 3 | 1 3.0|
Infarct | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 2 | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | 2 3 3 2 2 1 3 | 13 2.3|
Hyperplasia | 1 | 1 1.0|
Inflammation, Acute | 2 2 2 2 2 2 3 3 | 16 2.2|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Retina, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 2 | 1 2.0|
Infarct | 2 | 1 2.0|
Nephropathy | 2 2 2 3 3 3 2 2 3 1 3 1 3 3 3 2 1 3 2 2 2 2 1| 47 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 0| 7| 3| 3| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 6| 3| 3| 3| 7| 5| 3| 3| 3|
| 5| 8| 7| 7| 3| 7| 6| 6| 0| 6| 6| 6| 6| 5| 6| 7| 2| 7| 7| 7| 0| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + A + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + A + + + A + + + +|
Inflammation, Granulomatous | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + A + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + A + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X X|
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X |
Fatty Change, Diffuse | 2 1 1 1 1 1 2 2 1 1 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Hemorrhage | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + + + + M + + + A + + + +|
Thrombosis | 4 |
Acinus, Atrophy | 2 2 2 2 1 2 2 2 3 2 2 |
Acinus, Hyperplasia | 4 3 2 2 1 2 3 2 3 3 2 1 1 2 3|
Artery, Hyperplasia | 3 |
Artery, Inflammation, Chronic Active | 2 3 3 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 2 2 2 2 1 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperkeratosis | 3 |
Hyperplasia, Basal Cell | 2 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Mineralization | 1 |
__________________________________________________________________________|
Tongue | + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 0| 7| 3| 3| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 6| 3| 3| 3| 7| 5| 3| 3| 3|
| 5| 8| 7| 7| 3| 7| 6| 6| 0| 6| 6| 6| 6| 5| 6| 7| 2| 7| 7| 7| 0| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 3 2 2 3 2 2 2 3 3 2 2 2 2 3 3 2 2 3 3 2 3 3 2 2|
Pigmentation | 2 |
Thrombosis | 4 |
Artery, Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 1 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + M + + + A + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 3 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Bilateral, C-Cell, Hyperplasia | |
C-Cell, Hyperplasia | 2 1 2 1|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ductus Deferens | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 2|
Hyperplasia, Squamous | 4 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 |
Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 |
Seminiferous Tubule, Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 0| 7| 3| 3| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 6| 3| 3| 3| 7| 5| 3| 3| 3|
| 5| 8| 7| 7| 3| 7| 6| 6| 0| 6| 6| 6| 6| 5| 6| 7| 2| 7| 7| 7| 0| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Angiectasis | 2 |
Mediastinal, Pigmentation | 3 2 2 |
Pancreatic, Ectasia | 2 |
Pancreatic, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +|
Fibrosis | 3 2 3 2 1 2 2 4 |
Hematopoietic Cell Proliferation | 2 |
Infarct | |
Pigmentation | 3 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + M + +|
Epithelial Cell, Hyperplasia | 3 2 2 2 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + + + + + + + + + + + M M M + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Developmental Malformation | |
Erosion | |
Mineralization | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Foreign Body | |
Hemorrhage | 2 2|
Inflammation, Acute | 3 |
Inflammation, Granulomatous | |
Alveolar Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 0| 7| 3| 3| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 6| 3| 3| 3| 7| 5| 3| 3| 3|
| 5| 8| 7| 7| 3| 7| 6| 6| 0| 6| 6| 6| 6| 5| 6| 7| 2| 7| 7| 7| 0| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 2 2 1 3 3 |
Inflammation, Acute | 2 1 2 3 2 2 3 2 3 |
Respiratory Epithelium, | |
Hyperkeratosis | 3 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Sclera, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + M + + + + + + + + A + + + + + + + +|
Hydronephrosis | |
Nephropathy | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + A + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 0| 3| 3| 3| 7| 3| 0| 9| 3| 2| 3| 1| 3| 3| 3| 6| 3| 3| 8| 3| 3| 3| 3| 3| 2| |
| 9| 7| 7| 7| 5| 6| 7| 9| 6| 0| 7| 9| 7| 7| 7| 9| 6| 6| 6| 6| 6| 6| 6| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
2.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + A| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + A| 45 |
Inflammation, Granulomatous | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + A| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + A| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 38 |
Clear Cell Focus | X X X X X X X X X X X X X X | 27 |
Degeneration, Cystic | 1 | 2 1.0|
Eosinophilic Focus | X X | 4 |
Fatty Change, Diffuse | 1 1 1 1 1 1 1 1 1 | 19 1.2|
Hepatodiaphragmatic Nodule | X X X | 4 |
Mixed Cell Focus | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 8 |
Fat, Hemorrhage | 3 | 1 3.0|
Fat, Necrosis | 3 3 2 2 3 | 5 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Thrombosis | | 1 4.0|
Acinus, Atrophy | 2 3 3 1 1 2 1 2 2 2 2 2 1 2 | 25 1.9|
Acinus, Hyperplasia | 1 2 4 2 2 2 2 2 2 1 2 3 2| 28 2.2|
Artery, Hyperplasia | | 1 3.0|
Artery, Inflammation, Chronic Active | 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Metaplasia, Squamous | 1 2 2 1 2 | 11 1.7|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 1 3.0|
Hyperkeratosis | | 1 3.0|
Hyperplasia, Basal Cell | | 2 1.5|
Ulcer | 3 2 1 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 2 1.5|
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 0| 3| 3| 3| 7| 3| 0| 9| 3| 2| 3| 1| 3| 3| 3| 6| 3| 3| 8| 3| 3| 3| 3| 3| 2| |
| 9| 7| 7| 7| 5| 6| 7| 9| 6| 0| 7| 9| 7| 7| 7| 9| 6| 6| 6| 6| 6| 6| 6| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
2.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | + | 2 |
Hemorrhage | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 2 2 3 2 3 3 2 3 3 2 2 2 3 2 2 3 2 2 3 3| 46 2.4|
Pigmentation | | 1 2.0|
Thrombosis | | 1 4.0|
Artery, Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | 2 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 1 1 3 2 1 2 | 12 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 3 2 | 5 2.4|
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 1 2 | 13 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, C-Cell, Hyperplasia | 2 | 1 2.0|
C-Cell, Hyperplasia | 2 1 2 2 | 8 1.6|
Follicular Cell, Hyperplasia | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ductus Deferens | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 3 2 | 4 2.3|
Hyperplasia, Squamous | | 1 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 | 6 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 0| 3| 3| 3| 7| 3| 0| 9| 3| 2| 3| 1| 3| 3| 3| 6| 3| 3| 8| 3| 3| 3| 3| 3| 2| |
| 9| 7| 7| 7| 5| 6| 7| 9| 6| 0| 7| 9| 7| 7| 7| 9| 6| 6| 6| 6| 6| 6| 6| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
2.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 3 | 3 2.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 | 3 2.0|
Seminiferous Tubule, Atrophy | | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 4 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 15 |
Mediastinal, Angiectasis | 2 3 | 3 2.3|
Mediastinal, Pigmentation | 2 | 4 2.3|
Pancreatic, Ectasia | 2 | 2 2.0|
Pancreatic, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 2 | 9 2.3|
Hematopoietic Cell Proliferation | 1 2 | 3 1.7|
Infarct | 3 | 1 3.0|
Pigmentation | 2 | 2 2.5|
Capsule, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + M M| 45 |
Epithelial Cell, Hyperplasia | | 5 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M + + + + + + M + + + + M + + M + M + + + +| 39 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X X X | 4 |
Developmental Malformation | 3 | 1 3.0|
Erosion | 3 | 1 3.0|
Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | X | 2 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 0| 3| 3| 3| 7| 3| 0| 9| 3| 2| 3| 1| 3| 3| 3| 6| 3| 3| 8| 3| 3| 3| 3| 3| 2| |
| 9| 7| 7| 7| 5| 6| 7| 9| 6| 0| 7| 9| 7| 7| 7| 9| 6| 6| 6| 6| 6| 6| 6| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
2.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Atrophy | 2 | 8 1.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 1 | 1 1.0|
Foreign Body | 2 | 1 2.0|
Hemorrhage | | 2 2.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Granulomatous | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | 3 2 3 3 3 2 | 12 2.5|
Inflammation, Acute | 2 3 2 3 2 2 2 2 | 17 2.2|
Respiratory Epithelium, | | |
Hyperkeratosis | 2 | 3 2.7|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 2 |
Sclera, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hydronephrosis | 3 | 1 3.0|
Nephropathy | 3 2 2 1 2 2 1 2 3 2 3 2 2 2 2 2 1 3 2 2 2 2 | 43 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 7| 3| 6| 3| 3| 6| 3| 3|
| 5| 5| 5| 6| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 6| 4| 0| 4| 4| 9| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + A + + + + + + + +|
Fibrosis | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X |
Eosinophilic Focus | X X X |
Fatty Change, Diffuse | 1 1 1 1 1 2 1 1 1 1 |
Hepatodiaphragmatic Nodule | X X X X X |
Mixed Cell Focus | X X X X X |
Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2|
Acinus, Hyperplasia | 3 4 2 2 3 2 2 2 2 4 3 2 2 1 2 1 |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 2 2 1 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 2 3 2 2 2 3 2 3 2 3 2 3 3 2 2 2 2 3 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + M + + + + + M + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 7| 3| 6| 3| 3| 6| 3| 3|
| 5| 5| 5| 6| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 6| 4| 0| 4| 4| 9| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Hyperplasia | |
C-Cell, Hyperplasia | 2 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 |
Seminiferous Tubule, Atrophy | 3 3 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Angiectasis | 3 |
Mediastinal, Pigmentation | 3 |
Pancreatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Ectasia | |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 |
Hematopoietic Cell Proliferation | 2 3 3 3 |
Infarct | 2 |
Pigmentation | |
Capsule, Hemorrhage | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + M + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 7| 3| 6| 3| 3| 6| 3| 3|
| 5| 5| 5| 6| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 6| 4| 0| 4| 4| 9| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + M M + M + + M + + + + + M + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Fibrosis | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 3 3 2 2 3 3 3 3 2 3 2|
Inflammation, Acute | 2 2 3 2 2 2 3 2 2 3 3 2 2 3 2|
Metaplasia, Cartilagenous | |
Respiratory Epithelium, | |
Hyperkeratosis | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Synechia | |
Lens, Cataract | 1 |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 2 1 2 1 1 1 2 2 2 1 1 1 3 1 1 2 2 1 3 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 6| 3| 3| 2| 3| 3| 3| |
| 4| 2| 4| 4| 5| 6| 6| 6| 4| 6| 6| 6| 5| 4| 6| 4| 6| 4| 2| 4| 2| 6| 4| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
5.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X| 37 |
Clear Cell Focus | X X X X X X X X X X X X | 24 |
Eosinophilic Focus | X | 4 |
Fatty Change, Diffuse | 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1| 27 1.1|
Hepatodiaphragmatic Nodule | X X X | 8 |
Mixed Cell Focus | X X X | 8 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Fat, Necrosis | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 2 2 1 1 2 3 1 2 1 2 1 3 2 1 1 2| 32 1.8|
Acinus, Hyperplasia | 2 3 2 2 2 2 1 2 3 2 2 1 | 28 2.2|
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Metaplasia, Squamous | 1 1 1 2 | 8 1.5|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 | 2 2.0|
Hyperplasia, Basal Cell | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 3 2 2 2 2 3 3 3 2 2 2 2 2 2 3 2 2 2 3 2| 47 2.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 6| 3| 3| 2| 3| 3| 3| |
| 4| 2| 4| 4| 5| 6| 6| 6| 4| 6| 6| 6| 5| 4| 6| 4| 6| 4| 2| 4| 2| 6| 4| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
5.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 4 1 1 1 2 1| 11 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M + M + + + M + + M + M + + + M + +| 40 |
Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Pars Distalis, Angiectasis | 3 2 | 4 2.8|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 2 3 2| 9 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Bilateral, C-Cell, Hyperplasia | 2 | 1 2.0|
C-Cell, Hyperplasia | 1 1 2 | 7 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 3 3 | 5 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 | 7 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 1 1 | 4 1.5|
Seminiferous Tubule, Atrophy | | 4 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 13 |
Mediastinal, Angiectasis | 3 3 3 2 | 5 2.8|
Mediastinal, Pigmentation | | 1 3.0|
Pancreatic, Angiectasis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Ectasia | 3 | 1 3.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 6| 3| 3| 2| 3| 3| 3| |
| 4| 2| 4| 4| 5| 6| 6| 6| 4| 6| 6| 6| 5| 4| 6| 4| 6| 4| 2| 4| 2| 6| 4| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
5.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 3 2.7|
Hematopoietic Cell Proliferation | 3 | 5 2.8|
Infarct | 3 | 2 2.5|
Pigmentation | 3 | 1 3.0|
Capsule, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + + + + + + + + M + + + + + + +| 45 |
Epithelial Cell, Hyperplasia | 3 2 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + M + + + + M + + + + M + + + + + M + + +| 39 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 2 |
Fibrosis | | 1 2.0|
Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 | 2 2.5|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Fungus | 2 3 3 3 3 1| 18 2.6|
Inflammation, Acute | 2 2 3 2 3 1| 21 2.3|
Metaplasia, Cartilagenous | 2 | 1 2.0|
Respiratory Epithelium, | | |
Hyperkeratosis | 3 | 1 3.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 3 2 | 7 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 6| 3| 3| 2| 3| 3| 3| |
| 4| 2| 4| 4| 5| 6| 6| 6| 4| 6| 6| 6| 5| 4| 6| 4| 6| 4| 2| 4| 2| 6| 4| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
5.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 2 |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Synechia | 2 | 1 2.0|
Lens, Cataract | 3 | 2 2.0|
Retina, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 2 3 1 1 1 2 1 1 1 2 1 3 1 1 2 2 1 2 1 1| 45 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 0| 3| 2| 9| 7| 3| 3| 3| 3| 3| 3| 3| 2| 3|
| 1| 1| 1| 1| 0| 1| 1| 1| 6| 1| 1| 5| 1| 3| 2| 2| 1| 1| 1| 4| 1| 1| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X|
Eosinophilic Focus | X X X X |
Fatty Change, Diffuse | 2 1 1 1 1 1 2 1 1 1 1 1 1 3 |
Fatty Change, Focal | 1 1 3 |
Hepatodiaphragmatic Nodule | X X|
Mixed Cell Focus | X X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Mineralization | 2 |
Fat, Necrosis | 4 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia | 2 |
Acinus, Atrophy | 2 2 1 2 2 2 2 2 2 1 1 2|
Acinus, Hyperplasia | 2 1 2 3 3 2 2 2 2 2 2 2 2 2 1 1 2 2 3|
Acinus, Hypertrophy, Focal | 2 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + + + + + + +|
Duct, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
Hyperplasia, Basal Cell | 2 2 1 1 |
Ulcer | 2 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +|
Erosion | 2 |
Mineralization | 2 |
__________________________________________________________________________|
Tongue | + |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 2 2|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 0| 3| 2| 9| 7| 3| 3| 3| 3| 3| 3| 3| 2| 3|
| 1| 1| 1| 1| 0| 1| 1| 1| 6| 1| 1| 5| 1| 3| 2| 2| 1| 1| 1| 4| 1| 1| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 1 2 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3|
Pars Distalis, Hyperplasia | 3 2 1 3 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 3 1 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Abscess | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 3 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + M +|
Interstitial Cell, Hyperplasia | 2 2|
Seminiferous Tubule, Atrophy | 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Angiectasis | |
Mediastinal, Pigmentation | 3 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 1 1 |
Pancreatic, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + M +|
Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +|
Angiectasis | 2 |
Fibrosis | 3 3 2 |
Hematopoietic Cell Proliferation | 1 1 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 0| 3| 2| 9| 7| 3| 3| 3| 3| 3| 3| 3| 2| 3|
| 1| 1| 1| 1| 0| 1| 1| 1| 6| 1| 1| 5| 1| 3| 2| 2| 1| 1| 1| 4| 1| 1| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Lipocyte | |
Metaplasia | |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + M + + M M +|
Epithelial Cell, Hyperplasia | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + M M + + + + + + + + M M|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hemorrhage | 4 |
Hyperkeratosis | 3 3 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + M + + + + + + + + + + +|
Fungus | 3 2 3 3 3|
Inflammation, Acute | 1 1 1 1 2 1 2 2 3 2 3|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Synechia | 2 3 |
Retina, Atrophy | 3 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 0| 3| 2| 9| 7| 3| 3| 3| 3| 3| 3| 3| 2| 3|
| 1| 1| 1| 1| 0| 1| 1| 1| 6| 1| 1| 5| 1| 3| 2| 2| 1| 1| 1| 4| 1| 1| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + A + + + + + + + + + + +|
Nephropathy | 2 1 2 1 1 2 1 1 1 1 2 2 1 2 1 2 1 3 3|
Cortex, Mineralization | 2 |
Papilla, Mineralization | 1 1 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 6| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 0| 4| 4| 2| 4| 4| 4| 5| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
10.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + A + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + A + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 46 |
Clear Cell Focus | X X X X X X X X X X X X X X | 21 |
Eosinophilic Focus | X X | 6 |
Fatty Change, Diffuse | 1 2 1 1 1 2 1 1 2 1 1 2 1 1 2 1 2 1 1| 33 1.3|
Fatty Change, Focal | | 3 1.7|
Hepatodiaphragmatic Nodule | X X X | 5 |
Mixed Cell Focus | X X X | 8 |
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Fat, Mineralization | 2 | 2 2.0|
Fat, Necrosis | 3 2 3 3 | 7 3.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia | | 1 2.0|
Acinus, Atrophy | 2 1 1 2 2 2 2 2 1 1 3 1| 24 1.7|
Acinus, Hyperplasia | 4 3 2 2 2 2 2 2 3 2 1 2 2 4 2 2 | 35 2.1|
Acinus, Hypertrophy, Focal | | 1 2.0|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Duct, Metaplasia, Squamous | 1 2 2 1 2 1 2| 8 1.6|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 1 2 2 3 | 5 1.8|
Hyperplasia, Basal Cell | 2 2 2 2 | 8 1.8|
Ulcer | | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Erosion | 2 | 2 2.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + | 3 |
Hyperplasia, Squamous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 6| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 0| 4| 4| 2| 4| 4| 4| 5| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
10.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 2 2 3 2 2 3 2 2 3 2 2 1 2 2 2 3 2 2 3 3 3 3| 45 2.2|
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Hyperplasia | 1 1 4| 9 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + M + M + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 2 3 2 | 6 2.5|
Pars Distalis, Hyperplasia | 2 3 2 3 | 9 2.3|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 1 1 2 2 | 11 1.5|
Follicular Cell, Hyperplasia | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Abscess | 2 2 2 3 3 | 7 2.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Hyperplasia | 2 2 | 4 2.3|
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Interstitial Cell, Hyperplasia | 2 2 | 4 2.0|
Seminiferous Tubule, Atrophy | 3 3 3 3 | 6 3.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 8 |
Mediastinal, Angiectasis | 3 | 1 3.0|
Mediastinal, Pigmentation | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 6| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 0| 4| 4| 2| 4| 4| 4| 5| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
10.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 2 1.0|
Pancreatic, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Fibrosis | 3 | 4 2.8|
Hematopoietic Cell Proliferation | 2 2 2 | 5 1.6|
Infiltration Cellular, Lipocyte | 3 | 1 3.0|
Metaplasia | 3 | 1 3.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 | 9 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + + M + + + + + + + + + + + + + + M + + M +| 40 |
Galactocele | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 2 |
Hemorrhage | | 1 4.0|
Hyperkeratosis | | 2 3.0|
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | | 1 3.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 6| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 0| 4| 4| 2| 4| 4| 4| 5| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
10.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fungus | 2 3 2 3 2 2 1 3 2 3| 15 2.5|
Inflammation, Acute | 2 2 2 2 2 2 2 2 1 2| 21 1.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 2 2 2 1 1 | 8 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Synechia | | 2 2.5|
Retina, Atrophy | | 2 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy | 1 1 1 1 2 2 1 1 2 1 1 3 1 1 2 2 2 2 1 1 1| 40 1.5|
Cortex, Mineralization | 1 | 2 1.5|
Papilla, Mineralization | | 2 1.0|
Renal Tubule, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 6| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 0| 2| 9| 7| 3| 3| 0| 9| 8| 2| 2| 3| 1| 3| 3| 3| 2| 2| 2| 2| 2|
| 0| 0| 0| 2| 0| 9| 1| 0| 0| 0| 7| 8| 3| 9| 9| 0| 9| 0| 0| 0| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Erosion | 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X |
Eosinophilic Focus | X X |
Fatty Change, Diffuse | 1 |
Fatty Change, Focal | 1 |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X X X |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Chronic Active | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 1 2 2 2 2 1 2 1 2 1 2 2 3 2 1 2 1|
Acinus, Hyperplasia | 3 1 3 3 |
Artery, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 3 2 2 2 3 2 2 2 3 2 2 3 3 3 2 2 |
Thrombosis | |
Artery, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 6| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 0| 2| 9| 7| 3| 3| 0| 9| 8| 2| 2| 3| 1| 3| 3| 3| 2| 2| 2| 2| 2|
| 0| 0| 0| 2| 0| 9| 1| 0| 0| 0| 7| 8| 3| 9| 9| 0| 9| 0| 0| 0| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 3 3 |
Rathke's Cleft, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 |
Seminiferous Tubule, Atrophy | 4 4|
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Lumbar, Pigmentation | |
Mediastinal, Angiectasis | 2 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 3 2 2 |
Hematopoietic Cell Proliferation | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 6| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 0| 2| 9| 7| 3| 3| 0| 9| 8| 2| 2| 3| 1| 3| 3| 3| 2| 2| 2| 2| 2|
| 0| 0| 0| 2| 0| 9| 1| 0| 0| 0| 7| 8| 3| 9| 9| 0| 9| 0| 0| 0| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infarct | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M M + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Epithelial Cell, Hyperplasia | 2 2 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + M + M + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 2 3 2 |
Inflammation, Granulomatous | |
Metaplasia, Osseous | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 3 2 3 2 3 2 |
Inflammation, Acute | 2 3 2 3 2 3 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Synechia | 3 |
Lens, Cataract | 3 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +|
Nephropathy | 2 3 2 2 2 1 2 2 3 2 2 2 2 2 2 2 2 2 1 2 1 1 2|
Cortex, Mineralization | |
Cortex, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 6| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 0| 2| 9| 7| 3| 3| 0| 9| 8| 2| 2| 3| 1| 3| 3| 3| 2| 2| 2| 2| 2|
| 0| 0| 0| 2| 0| 9| 1| 0| 0| 0| 7| 8| 3| 9| 9| 0| 9| 0| 0| 0| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 3| 6| 7| 7| 6| 6| |
DAY ON TEST | 0| 3| 3| 7| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 3| 6| 2| 2| 6| 8| 3| 2| 5| 6| |
| 1| 0| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 0| 9| 0| 0| 1| 8| 9| 0| 5| 0| 3| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
10 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + + M + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 3| 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | | 1 2.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.5|
Basophilic Focus | X X X X X X X X X X X X X X X X X | 33 |
Clear Cell Focus | X X X X X X X X X X | 16 |
Eosinophilic Focus | X | 3 |
Fatty Change, Diffuse | 1 | 2 1.0|
Fatty Change, Focal | 1 2 2| 4 1.5|
Hepatodiaphragmatic Nodule | X X X X | 6 |
Mixed Cell Focus | X X | 5 |
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Fat, Inflammation, Chronic Active | | 1 3.0|
Fat, Necrosis | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 2 3 1 2 2 1 2 1 2 2 2 1 2 2 2 3 2 2 1| 40 1.8|
Acinus, Hyperplasia | 2 | 5 2.4|
Artery, Inflammation, Chronic Active | 2 | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Metaplasia, Squamous | 1 1 1 2 | 6 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | | 1 2.0|
Hyperplasia, Basal Cell | 1 2 1 | 4 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 3| 4 2.3|
Hyperplasia | 2 | 3 1.3|
__________________________________________________________________________|____________|
Tongue | + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 2 2 3 2 2 2 2 3 2 2 2 2 2 2 2 2 2| 42 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 3| 6| 7| 7| 6| 6| |
DAY ON TEST | 0| 3| 3| 7| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 3| 6| 2| 2| 6| 8| 3| 2| 5| 6| |
| 1| 0| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 0| 9| 0| 0| 1| 8| 9| 0| 5| 0| 3| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
10 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Thrombosis | 3 | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | 2 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + M + + + + + + + + + + + + +| 47 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 2 2 | 6 2.2|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 2 2 3 2 | 9 2.3|
Rathke's Cleft, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 2 2 2| 9 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Spermatocele | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 2 2 3 | 4 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 | 4 1.5|
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 2 2| 4 1.8|
Seminiferous Tubule, Atrophy | 3 4 | 4 3.8|
Seminiferous Tubule, Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 3| 6| 7| 7| 6| 6| |
DAY ON TEST | 0| 3| 3| 7| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 3| 6| 2| 2| 6| 8| 3| 2| 5| 6| |
| 1| 0| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 0| 9| 0| 0| 1| 8| 9| 0| 5| 0| 3| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
10 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + +| 22 |
Lumbar, Pigmentation | 3| 1 3.0|
Mediastinal, Angiectasis | | 1 2.0|
Renal, Pigmentation | 2| 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 3 | 8 2.4|
Hematopoietic Cell Proliferation | 2 1 2 2 2 2 | 6 1.8|
Infarct | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 1 2.0|
Epithelial Cell, Hyperplasia | 2 2 2 | 7 2.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M M M + + + + + + + M + M + + + + + + +| 42 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Histiocyte | 2 | 5 2.2|
Inflammation, Granulomatous | 1 | 1 1.0|
Metaplasia, Osseous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | 3 2 3 1 3 | 12 2.4|
Inflammation, Acute | 3 2 1 2 3 2 | 14 2.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 3 2 2 | 8 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05143-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CORN OIL Date: 04/25/97
Route: GAVAGE Time: 08:31:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 3| 6| 7| 7| 6| 6| |
DAY ON TEST | 0| 3| 3| 7| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 3| 6| 2| 2| 6| 8| 3| 2| 5| 6| |
| 1| 0| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 0| 9| 0| 0| 1| 8| 9| 0| 5| 0| 3| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
10 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + | 3 |
Synechia | | 1 3.0|
Lens, Cataract | 2 | 2 2.5|
Retina, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy | 2 3 2 1 2 2 1 1 1 3 2 2 3 2 3 2 1 1 1 2 2 2 | 45 1.9|
Cortex, Mineralization | 2 | 1 2.0|
Cortex, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------