TDMS Study 05143-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/17/94
EXP: 05143 CORN OIL / CORN OIL TIME: 18:54:35
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 00577
CONT: N01-ES-55123 CAS: 8001-30-7
PATHOLOGIST: K. MURTHY S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/17/94
EXP: 05143 CORN OIL / CORN OIL TIME: 18:54:35
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 00577
CONT: N01-ES-55123 CAS: 8001-30-7
PATHOLOGIST: K. MURTHY S. EUSTIS
CORN OIL / CORN OIL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 ML/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 216 523 569 610 618 620 635 638 651 678 |
| 681 683 685 687 688 688 691 697 697 704 |
| 704 704 710 715 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 ML/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 272 360 483 591 598 600 628 658 661 661 |
| 670 671 685 701 707 719 723 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5 ML/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 409 420 520 562 575 586 599 619 653 656 |
| 669 670 678 695 705 707 720 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
CORN OIL / CORN OIL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 5.0 ML/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 386 432 555 560 562 569 576 632 706 707 |
| 721 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10.0 ML/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 575 576 622 623 664 672 680 692 705 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
CORN OIL / CORN OIL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 ML/KG | 100.0 100.0 98.0 98.0 98.0 98.0 96.0 94.0 82.0 52.0 |
| | |
| | |
|10 | 100.0 100.0 100.0 96.0 96.0 94.0 94.0 88.0 80.0 64.0 |
|ML/KG | |
| | |
|2.5 | 100.0 100.0 100.0 100.0 96.0 96.0 94.0 86.0 80.0 66.0 |
|ML/KG | |
| | |
|5.0 | 100.0 100.0 100.0 100.0 98.0 96.0 96.0 86.0 84.0 76.0 |
|ML/KG | |
| | |
|10.0 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 90.0 80.0 |
|ML/KG | |
| | |
==================================================================================
CORN OIL / CORN OIL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 ML/KG 10 2.5 5.0 10.0 |
| ML/KG ML/KG ML/KG ML/KG |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.0% 64.0% 66.0% 76.0% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.017N ----- P=0.305N P=0.029N P=0.007N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 645.5 617.4 614.3 594.3 653.1 |
|NATURAL DEATHS (C) | (21.1) (29.7) (22.9) (31.9) (16.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 688.9 688.8 690.0 696.7 713.8 |
|(STANDARD ERROR) | (11.6) (13.0) (10.9) (11.1) ( 5.4) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
CORN OIL / CORN OIL
KAPLAN-MEIER SURVIVAL CURVES
0 ML/KG = 1
10 ML/KG = 2
2.5 ML/KG = 3
5.0 ML/KG = 4
10.0 ML/KG = 5
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 2 4 3 5
|
| 1 2 2 4 33 4 1
| 2 3 4 2 1 4 15 5
95 +
| 2 3 31 2 1
| 43 3 22 11 5
|
90 + 4433 55
|
| 443 2 121 5 5
| 4 3 3211 2 55
P 85 +
E | 3 4112 2 5 4
R | 1 1 5 5
C |
E 80 + 3 2211 4 45 5
N |
T | 44
| 232 4 4
S 75 +
U | 31132
R | 33
V |
I 70 + 2 2
V |
A | 3 22
L | 11 3 3
65 +
| 2 2
| 11
|
60 +
|
|
| 11
55 +
| 11
| 1 1
|
50 +
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.