TDMS Study 05144-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
SAFFLOWER OIL
NTP Experiment-Test: 05144-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/17/94
Route: GAVAGE Time: 19:47:02
Facility: TSI Mason Research
Chemical CAS #: 8001-23-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05144-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SAFFLOWER OIL Date: 09/17/94
Route: GAVAGE Time: 19:47:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 2.5 MLKG 5.0 MLKG 10.0
ML/KG
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DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 9
Early Deaths
Natural Death 8 8 3 10
Moribund Sacrifice 12 9 7 5
Survivors
Terminal Sacrifice 30 33 40 36
Animals Examined Microscopically 60 60 60 60
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ALIMENTARY SYSTEM
Esophagus (59) (58) (58) (58)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Intestine Large, Colon (56) (59) (58) (58)
Sarcoma 1 (2%)
Intestine Large, Rectum (57) (57) (57) (56)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Intestine Large, Cecum (55) (58) (57) (57)
Intestine Small, Duodenum (58) (60) (58) (58)
Intestine Small, Jejunum (55) (58) (57) (55)
Intestine Small, Ileum (55) (59) (58) (56)
Liver (60) (60) (60) (60)
Carcinoma, Metastatic, Pancreas 1 (2%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Hepatocellular Adenoma 2 (3%) 2 (3%) 1 (2%)
Mesentery (10) (8) (11) (7)
Pancreas (60) (60) (59) (59)
Acinus, Adenoma 1 (2%) 5 (8%) 9 (15%) 10 (17%)
Acinus, Adenoma, Multiple 2 (3%) 6 (10%) 19 (32%)
Acinus, Carcinoma 1 (2%)
Acinus, Carcinoma, Multiple 1 (2%)
Acinus, Mixed Tumor Benign 1 (2%)
Pharynx (1)
Palate, Squamous Cell Carcinoma 1 (100%)
Salivary Glands (60) (59) (60) (60)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Stomach, Forestomach (60) (60) (60) (60)
Squamous Cell Papilloma 1 (2%) 2 (3%) 1 (2%)
Stomach, Glandular (59) (60) (59) (59)
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NTP Experiment-Test: 05144-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SAFFLOWER OIL Date: 09/17/94
Route: GAVAGE Time: 19:47:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 2.5 MLKG 5.0 MLKG 10.0
ML/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Carcinoma 1 (2%)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%)
Tooth (1)
Odontoma 1 (100%)
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CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
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ENDOCRINE SYSTEM
Adrenal Cortex (60) (59) (60) (58)
Adenoma 2 (3%)
Adrenal Medulla (59) (58) (59) (58)
Ganglioneuroma 1 (2%)
Pheochromocytoma Malignant 2 (3%) 1 (2%)
Pheochromocytoma Benign 14 (24%) 10 (17%) 8 (14%) 7 (12%)
Bilateral, Pheochromocytoma Benign 1 (2%) 2 (3%) 3 (5%) 1 (2%)
Islets, Pancreatic (59) (60) (59) (58)
Adenoma 6 (10%) 2 (3%) 5 (8%) 3 (5%)
Adenoma, Multiple 1 (2%) 1 (2%)
Pituitary Gland (60) (58) (59) (59)
Pars Distalis, Adenoma 8 (13%) 10 (17%) 4 (7%) 8 (14%)
Thyroid Gland (58) (59) (58) (58)
C-Cell, Adenoma 5 (9%) 4 (7%) 8 (14%) 4 (7%)
Follicular Cell, Adenoma 2 (3%) 2 (3%) 1 (2%)
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GENERAL BODY SYSTEM
Tissue NOS (1) (1) (1)
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GENITAL SYSTEM
Epididymis (60) (60) (59) (60)
Preputial Gland (60) (60) (59) (58)
Adenoma 8 (13%) 6 (10%) 4 (7%) 2 (3%)
Bilateral, Adenoma 1 (2%) 1 (2%)
Prostate (59) (59) (58) (58)
Seminal Vesicle (60) (59) (60) (59)
Testes (60) (60) (59) (60)
Bilateral, Interstitial Cell, Adenoma 50 (83%) 46 (77%) 50 (85%) 47 (78%)
Interstitial Cell, Adenoma 7 (12%) 9 (15%) 6 (10%) 8 (13%)
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NTP Experiment-Test: 05144-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SAFFLOWER OIL Date: 09/17/94
Route: GAVAGE Time: 19:47:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 2.5 MLKG 5.0 MLKG 10.0
ML/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
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HEMATOPOIETIC SYSTEM
Blood (15) (11) (7) (2)
Bone Marrow (59) (59) (60) (59)
Lymph Node (25) (19) (18) (8)
Lymph Node, Mandibular (60) (56) (57) (59)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Lymph Node, Mesenteric (59) (60) (59) (58)
Spleen (60) (60) (58) (60)
Thymus (50) (51) (51) (52)
Schwannoma Malignant, Metastatic, Uncertain
Primary Site 1 (2%)
Thymoma Benign 1 (2%) 1 (2%)
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INTEGUMENTARY SYSTEM
Mammary Gland (50) (52) (53) (51)
Fibroadenoma 6 (12%) 2 (4%) 1 (2%) 2 (4%)
Fibroadenoma, Multiple 1 (2%)
Skin (58) (59) (60) (60)
Basal Cell Adenoma 1 (2%)
Fibrous Histiocytoma 1 (2%)
Keratoacanthoma 1 (2%) 3 (5%) 1 (2%)
Squamous Cell Carcinoma 1 (2%) 1 (2%) 1 (2%)
Squamous Cell Papilloma 2 (3%) 2 (3%) 4 (7%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 3 (5%) 2 (3%) 2 (3%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (3%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
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MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Osteosarcoma 1 (2%)
Skeletal Muscle (50) (50) (50) (51)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Rhabdomyosarcoma 1 (2%)
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NTP Experiment-Test: 05144-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SAFFLOWER OIL Date: 09/17/94
Route: GAVAGE Time: 19:47:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 2.5 MLKG 5.0 MLKG 10.0
ML/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Astrocytoma Malignant 1 (2%)
Glioma Malignant 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Spinal Cord (1) (1)
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RESPIRATORY SYSTEM
Lung (60) (60) (60) (59)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Mediastinum, Sarcoma, Metastatic, Heart 1 (2%)
Mediastinum, Schwannoma Malignant 1 (2%)
Nose (60) (60) (60) (60)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Squamous Cell Papilloma 1 (2%)
Nasopharyngeal Duct, Squamous Cell Carcinoma 1 (2%)
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SPECIAL SENSES SYSTEM
Harderian Gland (1)
Carcinoma 1 (100%)
Zymbal's Gland (2)
Carcinoma 2 (100%)
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URINARY SYSTEM
Kidney (60) (60) (60) (58)
Sarcoma 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (58) (59) (59) (57)
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SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia Mononuclear 35 (58%) 19 (32%) 18 (30%) 7 (12%)
Mesothelioma Malignant 2 (3%) 2 (3%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05144-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SAFFLOWER OIL Date: 09/17/94
Route: GAVAGE Time: 19:47:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 2.5 MLKG 5.0 MLKG 10.0
ML/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 59 58 58 59
Total Primary Neoplasms 163 144 142 139
Total Animals with Benign Neoplasms 58 57 56 58
Total Benign Neoplasms 123 112 118 123
Total Animals with Malignant Neoplasms 38 29 23 15
Total Malignant Neoplasms 40 32 24 16
Total Animals with Metastatic Neoplasms 1 4 6
Total Metastatic Neoplasm 2 7 7
Total Animals with Malignant Neoplasms 1 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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