TDMS Study 05144-01 Pathology Tables
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
Facility: TSI Mason Research
Chemical CAS #: 8001-23-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 6| 4| 4| 4| 4| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6|
DAY ON TEST | 3| 3| 3| 4| 2| 4| 7| 6| 6| 6| 3| 1| 6| 3| 6| 3| 0| 3| 3| 3| 3| 3| 6| 7| 9|
| 9| 9| 5| 1| 7| 7| 6| 2| 2| 2| 9| 5| 1| 9| 2| 9| 8| 6| 9| 6| 9| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + A + + + + A + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + A + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia, Diffuse | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + A + + + + A + + + + + + + +|
Mucosa, Hyperplasia, Diffuse | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + A + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X|
Clear Cell Focus | X X X X 1 1 |
Cyst | X X |
Eosinophilic Focus | X X X |
Fatty Change, Focal | 1 2 2 3|
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | 3 |
Hyperplasia | 2 2 |
Mixed Cell Focus | |
Necrosis | 4 2 |
Thrombosis | 2 2|
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic Active | 3 |
Fat, Mineralization | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 3 2 1 2 3 2 2 1 1 2 1 1 2 1 2 2 2|
Acinus, Fibrosis | 2 |
Acinus, Hyperplasia | 1 3 2 1 2 |
Artery, Inflammation, Chronic Active | |
Vein, Angiectasis | 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia | |
Duct, Metaplasia, Squamous | 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 2 1 1 |
Hyperplasia, Basal Cell | 2 2 1 1 2 1 1 1 1 |
Ulcer | 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 1 2 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 6| 4| 4| 4| 4| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6|
DAY ON TEST | 3| 3| 3| 4| 2| 4| 7| 6| 6| 6| 3| 1| 6| 3| 6| 3| 0| 3| 3| 3| 3| 3| 6| 7| 9|
| 9| 9| 5| 1| 7| 7| 6| 2| 2| 2| 9| 5| 1| 9| 2| 9| 8| 6| 9| 6| 9| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 3 2 2 2|
Thrombosis | 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Granulomatous | |
Metaplasia, Osseous | |
Necrosis | |
Thrombosis | |
__________________________________________________________________________|
Adrenal Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 3 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + M + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 1 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + M + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 2 2 |
Cyst | |
Dilatation | 3 4 2 2 3 3 |
Dilatation, Multiple | |
Hyperplasia | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Acute | 3|
Metaplasia, Squamous | 3|
Interstitium, Edema | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 6| 4| 4| 4| 4| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6|
DAY ON TEST | 3| 3| 3| 4| 2| 4| 7| 6| 6| 6| 3| 1| 6| 3| 6| 3| 0| 3| 3| 3| 3| 3| 6| 7| 9|
| 9| 9| 5| 1| 7| 7| 6| 2| 2| 2| 9| 5| 1| 9| 2| 9| 8| 6| 9| 6| 9| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 4 4 4 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 |
Seminiferous Tubule, Atrophy | 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Mediastinal, Angiectasis | 2 |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Pigmentation | 2 2 |
Mediastinal, Lymphatic, Ectasia | |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 3 |
Pancreatic, Pigmentation | 2 |
Renal, Angiectasis | |
Renal, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Angiectasis | |
Hyperplasia, Lymphoid | |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Depletion Lymphoid | 4 4 |
Fibrosis | 3 2 2 2 |
Hematopoietic Cell Proliferation | 3 |
Infarct | 4 2 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + M M + M + M M + + + + + + + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + M + + + + + M M + + + + + + + M M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + M + + + + + + + + + M + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 6| 4| 4| 4| 4| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6|
DAY ON TEST | 3| 3| 3| 4| 2| 4| 7| 6| 6| 6| 3| 1| 6| 3| 6| 3| 0| 3| 3| 3| 3| 3| 6| 7| 9|
| 9| 9| 5| 1| 7| 7| 6| 2| 2| 2| 9| 5| 1| 9| 2| 9| 8| 6| 9| 6| 9| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia, Basal Cell | 3 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Abdominal, Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Fibrosis | |
Hemorrhage | 3 2 |
Infiltration Cellular, Histiocyte | 2 2 |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Alveolus, Inflammation, Acute | |
Alveolus, Pigmentation, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | 3 X 3 2 3 2 2 2 2 X 2|
Hyperkeratosis | 2 |
Inflammation, Acute | 3 3 4 2 2 2 2 2 2 2 2|
Metaplasia, Squamous | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Respiratory Epithelium, Hyperplasia | 2 2 2 3 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 1 2 2 1 2|
Vein, Thrombosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lumen, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 6| 4| 4| 4| 4| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6|
DAY ON TEST | 3| 3| 3| 4| 2| 4| 7| 6| 6| 6| 3| 1| 6| 3| 6| 3| 0| 3| 3| 3| 3| 3| 6| 7| 9|
| 9| 9| 5| 1| 7| 7| 6| 2| 2| 2| 9| 5| 1| 9| 2| 9| 8| 6| 9| 6| 9| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Necrosis | |
Lens, Cataract | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Glomerulosclerosis | 3 |
Nephropathy | 2 2 2 2 2 1 2 2 1 3 2 2 3 1 2 1 1 3 3 2 2 2 1 1|
Pigmentation | 2 |
Renal Tubule, Degeneration | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 6| 4| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 6| 6| 3| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 3| 9| 6| 3| 3| 1| 3| 3| 3| 6| 8| 3|
| 1| 1| 6| 2| 9| 6| 6| 1| 3| 6| 6| 6| 6| 6| 1| 1| 9| 6| 0| 9| 6| 9| 1| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Mucosa, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Mucosa, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X 1 1 X X 1 X X 1 X X X|
Cyst | |
Eosinophilic Focus | X X |
Fatty Change, Focal | 2 2 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | |
Hyperplasia | 2 2 |
Mixed Cell Focus | X |
Necrosis | 2 |
Thrombosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Inflammation, Chronic Active | |
Fat, Mineralization | 2 |
Fat, Necrosis | 3 3 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 2 1 3 2 3 4 3 2 3 3 2 2 1 2 2 3 2 1 |
Acinus, Fibrosis | |
Acinus, Hyperplasia | 1 |
Artery, Inflammation, Chronic Active | 2 |
Vein, Angiectasis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia | 1 |
Duct, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 1 2 1 |
Hyperplasia, Basal Cell | 1 1 1 1 1 1 1 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 2 1 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 6| 4| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 6| 6| 3| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 3| 9| 6| 3| 3| 1| 3| 3| 3| 6| 8| 3|
| 1| 1| 6| 2| 9| 6| 6| 1| 3| 6| 6| 6| 6| 6| 1| 1| 9| 6| 0| 9| 6| 9| 1| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 2 2 3 2 2 1 3 3 2 3 3 3 2 1 2 2 2 1 2 3|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Granulomatous | 3 |
Metaplasia, Osseous | |
Necrosis | |
Thrombosis | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 2 1 3 3 1 1 3 3 1 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + M + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 1 3 2 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 3 1 3 1 2 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 2 |
Cyst | 2 3 |
Dilatation | 2 |
Dilatation, Multiple | 3 |
Hyperplasia | 1 |
Inflammation, Acute | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | |
Metaplasia, Squamous | 1 |
Interstitium, Edema | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 6| 4| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 6| 6| 3| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 3| 9| 6| 3| 3| 1| 3| 3| 3| 6| 8| 3|
| 1| 1| 6| 2| 9| 6| 6| 1| 3| 6| 6| 6| 6| 6| 1| 1| 9| 6| 0| 9| 6| 9| 1| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 4 4 4 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 1 2 |
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Mediastinal, Angiectasis | 3 |
Mediastinal, Hematopoietic Cell | |
Proliferation | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | |
Mediastinal, Lymphatic, Ectasia | 2 |
Pancreatic, Hyperplasia, Lymphoid | 3 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Pigmentation | |
Renal, Angiectasis | |
Renal, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Depletion Lymphoid | |
Fibrosis | 3 2 1 3 2 2 3 |
Hematopoietic Cell Proliferation | |
Infarct | 3 |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + M + + + + + + M + + + + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X X |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 6| 4| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 6| 6| 3| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 3| 9| 6| 3| 3| 1| 3| 3| 3| 6| 8| 3|
| 1| 1| 6| 2| 9| 6| 6| 1| 3| 6| 6| 6| 6| 6| 1| 1| 9| 6| 0| 9| 6| 9| 1| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia, Basal Cell | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Abdominal, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 3 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3|
Fibrosis | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | 3 3 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Alveolus, Inflammation, Acute | |
Alveolus, Pigmentation, Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 1 1 |
Fungus | 3 2 2 2 2 3 3 |
Hyperkeratosis | |
Inflammation, Acute | 2 2 1 2 2 3 2 2 |
Metaplasia, Squamous | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Respiratory Epithelium, Hyperplasia | 2 1 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 2 2 2 |
Vein, Thrombosis | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Thrombosis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 6| 4| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 6| 6| 3| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 3| 9| 6| 3| 3| 1| 3| 3| 3| 6| 8| 3|
| 1| 1| 6| 2| 9| 6| 6| 1| 3| 6| 6| 6| 6| 6| 1| 1| 9| 6| 0| 9| 6| 9| 1| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 ML/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Necrosis | 3 |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Glomerulosclerosis | |
Nephropathy | 1 1 2 2 2 3 2 2 2 1 2 2 2 3 1 1 3 2 1 2 3 2 1 3 3|
Pigmentation | 3 2 2 |
Renal Tubule, Degeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| | |
DAY ON TEST | 6| 0| 3| 3| 1| 5| 3| 3| 3| 9| | |
| 2| 1| 6| 6| 0| 7| 9| 9| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 ML/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
Mucosa, Hyperplasia, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 55 |
Mucosa, Hyperplasia, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X X | 36 |
Clear Cell Focus | X X X 1 | 23 1.0|
Cyst | | 2 |
Eosinophilic Focus | | 5 |
Fatty Change, Focal | 2 | 7 2.0|
Hepatodiaphragmatic Nodule | | 4 |
Hyperplasia, Focal | | 1 3.0|
Hyperplasia | | 4 2.0|
Mixed Cell Focus | | 1 |
Necrosis | 2 | 4 2.5|
Thrombosis | | 3 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 10 |
Fat, Inflammation, Chronic Active | 2 | 2 2.5|
Fat, Mineralization | | 1 2.0|
Fat, Necrosis | 2 2 | 8 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 3 2 2 2 2 2 3 1 3 | 48 2.1|
Acinus, Fibrosis | | 1 2.0|
Acinus, Hyperplasia | 1 2 2 1 | 10 1.6|
Artery, Inflammation, Chronic Active | | 1 2.0|
Vein, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Metaplasia | | 1 1.0|
Duct, Metaplasia, Squamous | 1 2 | 14 1.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | 1 1 2 | 11 1.4|
Hyperplasia, Basal Cell | 1 1 2 2 | 21 1.2|
Ulcer | 3 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| | |
DAY ON TEST | 6| 0| 3| 3| 1| 5| 3| 3| 3| 9| | |
| 2| 1| 6| 6| 0| 7| 9| 9| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 ML/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Erosion | 2 | 8 1.8|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 3 2 2 2 2 3 2 | 56 2.2|
Thrombosis | | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia | | 1 1.0|
Inflammation, Granulomatous | | 1 3.0|
Metaplasia, Osseous | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | 1 1 | 23 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 5 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 55 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 2 | 4 2.0|
Pars Distalis, Cyst | | 2 1.0|
Pars Distalis, Hyperplasia | 2 1 | 9 1.8|
Pars Nervosa, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
C-Cell, Hyperplasia | 1 | 10 1.6|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Abscess | | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| | |
DAY ON TEST | 6| 0| 3| 3| 1| 5| 3| 3| 3| 9| | |
| 2| 1| 6| 6| 0| 7| 9| 9| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 ML/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | 3 | 3 2.7|
Dilatation | 2 | 8 2.6|
Dilatation, Multiple | | 1 3.0|
Hyperplasia | | 1 1.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Hyperplasia | | 1 1.0|
Inflammation, Acute | | 1 3.0|
Metaplasia, Squamous | | 2 2.0|
Interstitium, Edema | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Depletion Cellular | 4 4 4 | 18 3.9|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | 2 | 8 1.9|
Seminiferous Tubule, Atrophy | | 3 3.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + | 15 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 25 |
Mediastinal, Angiectasis | | 2 2.5|
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Pigmentation | | 2 2.0|
Mediastinal, Lymphatic, Ectasia | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 3 2.7|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Pancreatic, Pigmentation | | 1 2.0|
Renal, Angiectasis | 2 | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Infiltration Cellular, Plasma Cell | | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Angiectasis | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| | |
DAY ON TEST | 6| 0| 3| 3| 1| 5| 3| 3| 3| 9| | |
| 2| 1| 6| 6| 0| 7| 9| 9| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 ML/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
Depletion Lymphoid | | 2 4.0|
Fibrosis | 2 3 3 | 14 2.4|
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Infarct | | 3 3.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + | 50 |
Depletion Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + M + | 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
Cyst Epithelial Inclusion | | 2 |
Hyperkeratosis | | 1 2.0|
Hyperplasia, Basal Cell | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + | 50 |
Fibrosis | 2 | 1 2.0|
Abdominal, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 3.5|
Fibrosis | 2 | 1 2.0|
Hemorrhage | | 2 2.5|
Infiltration Cellular, Histiocyte | 2 | 4 2.3|
Inflammation, Acute | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 4 2.8|
Alveolus, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| | |
DAY ON TEST | 6| 0| 3| 3| 1| 5| 3| 3| 3| 9| | |
| 2| 1| 6| 6| 0| 7| 9| 9| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 ML/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Histiocyte | | 1 1.0|
Alveolus, Inflammation, Acute | 1 | 1 1.0|
Alveolus, Pigmentation, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | 1 1 1 | 7 1.1|
Fungus | 2 2 2 3 3 2 | 24 2.4|
Hyperkeratosis | | 1 2.0|
Inflammation, Acute | 2 2 2 1 3 3 2 | 26 2.2|
Metaplasia, Squamous | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 2 1 | 13 1.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 1 2 | 16 1.6|
Vein, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
Lumen, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Necrosis | | 1 3.0|
Lens, Cataract | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 2 |
Glomerulosclerosis | | 1 3.0|
Nephropathy | 2 2 3 3 2 2 2 2 3 2 | 59 2.0|
Pigmentation | 3 | 5 2.4|
Renal Tubule, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 3| 7| 4| 6| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 4| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 6| 8| 3| 6| 2| 3| 3| 3| 3| 3| 1| 3| 0| 6| 3| 3| 6| 6| 3| 9| 0|
| 5| 5| 5| 5| 1| 8| 5| 2| 4| 4| 6| 6| 6| 6| 5| 5| 8| 2| 5| 5| 1| 1| 5| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Fibrosis | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X 1 X|
Clear Cell Focus | X X X X X X X X X X X |
Eosinophilic Focus | X |
Fatty Change, Focal | |
Hepatodiaphragmatic Nodule | X X |
Hepatodiaphragmatic Nodule, Multiple | |
Hyperplasia | |
Mixed Cell Focus | X |
Necrosis | 3 1 |
Pigmentation, Hemosiderin | |
Pigmentation | |
Centrilobular, Degeneration | |
__________________________________________________________________________|
Mesentery | + + + + +|
Inflammation, Chronic Active | 3|
Fat, Hemorrhage | 2|
Fat, Mineralization | |
Fat, Necrosis | 2 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 1 2 2 2 2 2 2 2 3 1 2 1 1 1 2 1|
Acinus, Hyperplasia | 1 1 3 4 2 2 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Inflammation, Chronic | 2 |
Duct, Metaplasia, Squamous | 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 1 1 1 1 1 1 1|
Hyperplasia, Basal Cell | 1 1 1 1 1 1 1 2|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 |
Mucosa, Hyperplasia, Diffuse | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 3| 7| 4| 6| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 4| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 6| 8| 3| 6| 2| 3| 3| 3| 3| 3| 1| 3| 0| 6| 3| 3| 6| 6| 3| 9| 0|
| 5| 5| 5| 5| 1| 8| 5| 2| 4| 4| 6| 6| 6| 6| 5| 5| 8| 2| 5| 5| 1| 1| 5| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 3 2 3 3 3 2 3 2 2 2 2 2 2 3 2 2 3 2|
Mineralization | |
Thrombosis | 3 |
Atrium, Dilatation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 2 2 1 2 2 3 2 1 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + M M + + M M + + M + + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 1 1 1 2 2 3 1 |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 1 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | +|
Abdominal, Ectopic Tissue | X|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 1 |
Cyst | X |
Hyperplasia | |
Inflammation, Acute | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 2 2 |
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 3| 7| 4| 6| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 4| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 6| 8| 3| 6| 2| 3| 3| 3| 3| 3| 1| 3| 0| 6| 3| 3| 6| 6| 3| 9| 0|
| 5| 5| 5| 5| 1| 8| 5| 2| 4| 4| 6| 6| 6| 6| 5| 5| 8| 2| 5| 5| 1| 1| 5| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + +|
Mediastinal, Angiectasis | |
Mediastinal, Ectasia | 1 |
Mediastinal, Inflammation, Acute | |
Mediastinal, Pigmentation | 1 1|
Pancreatic, Angiectasis | |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M M + + + + + + + + + + M + + + + + + + +|
Angiectasis | 1 2|
Ectasia | |
Hyperplasia, Lymphoid | |
Inflammation, Acute | 2 |
Pigmentation | 2|
Lymphatic, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1|
Pigmentation | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis | 1 2 |
Hematopoietic Cell Proliferation | 3 2 3|
Pigmentation, Hemosiderin | |
Pigmentation | 3 2 3 |
__________________________________________________________________________|
Thymus | + + + + M M + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + M + + + + + + + + M + + + + + M M + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + M + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 3| 7| 4| 6| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 4| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 6| 8| 3| 6| 2| 3| 3| 3| 3| 3| 1| 3| 0| 6| 3| 3| 6| 6| 3| 9| 0|
| 5| 5| 5| 5| 1| 8| 5| 2| 4| 4| 6| 6| 6| 6| 5| 5| 8| 2| 5| 5| 1| 1| 5| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | |
Edema | 1 |
Hemorrhage, Focal | |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 |
Inflammation, Chronic | |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Foreign Body | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Interstitium, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 2 2 1 2 3 2 2 2 2 2 2 2 1 3 2 3 2|
Fungus | 2 1 3 3 2 2 3 2 3 3 3 2 2 2 2 1 1|
Inflammation, Acute | 2 3 2 2 2 2 2 3 3 3 3 2 3 3 2 2 3 3 2 3 2 2 3 3|
Respiratory Epithelium, Hyperplasia | 2 2 3 3 2 2 3 2 3 3 3 1 3 2 2 2 2 1 3 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 2 2 2 2 3 1 2 1 3 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 3 |
Nephropathy | 2 2 2 1 1 2 1 2 2 2 2 2 2 1 1 1 1 1 2 1 1 2 3 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 4| 6| 4| 6| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 4| 7|
DAY ON TEST | 3| 1| 6| 6| 6| 1| 9| 8| 7| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 9| 6| 3|
| 5| 0| 2| 1| 2| 8| 1| 3| 9| 2| 5| 6| 5| 5| 6| 5| 5| 5| 5| 5| 6| 7| 8| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X |
Eosinophilic Focus | X |
Fatty Change, Focal | 2 3 |
Hepatodiaphragmatic Nodule | X |
Hepatodiaphragmatic Nodule, Multiple | X |
Hyperplasia | |
Mixed Cell Focus | X |
Necrosis | 2 2 |
Pigmentation, Hemosiderin | 2 |
Pigmentation | |
Centrilobular, Degeneration | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic Active | |
Fat, Hemorrhage | |
Fat, Mineralization | 1 |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1 2 1 2 1 2 2 1 2 1 2 2 2 1 2 1|
Acinus, Hyperplasia | 1 3 4 2 1 1 |
Artery, Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
Duct, Metaplasia, Squamous | 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 1 1 1 2 |
Hyperplasia, Basal Cell | 2 1 1 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 1 |
Mucosa, Hyperplasia, Diffuse | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 4| 6| 4| 6| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 4| 7|
DAY ON TEST | 3| 1| 6| 6| 6| 1| 9| 8| 7| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 9| 6| 3|
| 5| 0| 2| 1| 2| 8| 1| 3| 9| 2| 5| 6| 5| 5| 6| 5| 5| 5| 5| 5| 6| 7| 8| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 3 3 3 2 2 2|
Mineralization | 1 |
Thrombosis | 3 |
Atrium, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 1 1 2 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2 |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 2 1 2 |
Pars Intermedia, Angiectasis | 1 |
__________________________________________________________________________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abdominal, Ectopic Tissue | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 2 |
Cyst | |
Hyperplasia | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1 2 2 1 2 1 |
Seminiferous Tubule, Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 4| 6| 4| 6| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 4| 7|
DAY ON TEST | 3| 1| 6| 6| 6| 1| 9| 8| 7| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 9| 6| 3|
| 5| 0| 2| 1| 2| 8| 1| 3| 9| 2| 5| 6| 5| 5| 6| 5| 5| 5| 5| 5| 6| 7| 8| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Mediastinal, Angiectasis | 1 |
Mediastinal, Ectasia | |
Mediastinal, Inflammation, Acute | 1 |
Mediastinal, Pigmentation | 2 |
Pancreatic, Angiectasis | 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Ectasia | 2 2|
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Pigmentation | 2 |
Lymphatic, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 3 3 4 2 |
Pigmentation, Hemosiderin | 2 |
Pigmentation | 3 3 2 3 3 3 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + M + + M + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + M + + + + + + + + + + + + + + + + + + +|
Galactocele | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 4| 6| 4| 6| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 4| 7|
DAY ON TEST | 3| 1| 6| 6| 6| 1| 9| 8| 7| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 2| 9| 6| 3|
| 5| 0| 2| 1| 2| 8| 1| 3| 9| 2| 5| 6| 5| 5| 6| 5| 5| 5| 5| 5| 6| 7| 8| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 4 2 |
Edema | |
Hemorrhage, Focal | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 3 1 2 2 |
Inflammation, Chronic | 2 |
Mineralization | 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Foreign Body | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Interstitium, Inflammation, Chronic | |
Active | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 3 2 2 2 3 3 2 2 2 2 1 2 2 1 2 2 2|
Fungus | 2 3 1 2 3 2 3 3 2 2 2 2 3 3 3 3 2 3 2 3|
Inflammation, Acute | 3 3 3 3 2 2 3 3 2 3 2 3 3 3 3 3 3 2 4 3 2 3 2 3 3|
Respiratory Epithelium, Hyperplasia | 2 2 2 2 2 1 2 3 2 3 2 3 2 2 3 2 3|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 3 3 2 1 2 2 2 2 2 2 2 2 3 1 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | |
Nephropathy | 3 3 1 1 1 1 1 1 2 3 1 2 1 1 3 2 2 2 2 3 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X X X |
Calculus Micro Observation Only | X X X |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| | |
| 5| 6| 6| 5| 5| 5| 5| 4| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X X X | 34 1.0|
Clear Cell Focus | X X X X | 22 |
Eosinophilic Focus | | 2 |
Fatty Change, Focal | 2 2 | 4 2.3|
Hepatodiaphragmatic Nodule | | 3 |
Hepatodiaphragmatic Nodule, Multiple | | 1 |
Hyperplasia | 2 | 1 2.0|
Mixed Cell Focus | | 2 |
Necrosis | | 4 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Pigmentation | 2 | 1 2.0|
Centrilobular, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 8 |
Inflammation, Chronic Active | | 1 3.0|
Fat, Hemorrhage | | 1 2.0|
Fat, Mineralization | | 1 1.0|
Fat, Necrosis | | 5 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 1 2 1 3 1 2 2 | 45 1.6|
Acinus, Hyperplasia | 3 2 3 | 15 2.2|
Artery, Inflammation, Chronic Active | 2 | 3 2.3|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + M + + | 59 |
Hyperplasia | | 2 1.5|
Inflammation, Chronic | | 1 2.0|
Duct, Metaplasia, Squamous | 1 1 1 1 1 | 11 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | 1 1 1 1 | 17 1.1|
Hyperplasia, Basal Cell | 1 1 2 1 1 | 17 1.2|
Ulcer | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| | |
| 5| 6| 6| 5| 5| 5| 5| 4| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | 2 2 | 6 1.8|
Mucosa, Hyperplasia, Diffuse | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 1 2 2 2 3 2 2 2 | 56 2.2|
Mineralization | | 1 1.0|
Thrombosis | 3 | 3 3.0|
Atrium, Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + M + + + + + + | 58 |
Hyperplasia | 2 1 2 3 1 | 24 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 3 2 | 4 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | | 6 2.3|
Pars Distalis, Cyst | X | 8 |
Pars Distalis, Hyperplasia | 2 3 3 1 3 3 | 16 1.9|
Pars Intermedia, Angiectasis | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | 1 | 6 1.7|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Abdominal, Ectopic Tissue | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Abscess | 2 3 | 6 1.8|
Cyst | X | 2 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| | |
| 5| 6| 6| 5| 5| 5| 5| 4| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Hyperplasia | 1 | 5 1.4|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | 2 | 11 1.5|
Seminiferous Tubule, Atrophy | | 3 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + | 11 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 19 |
Mediastinal, Angiectasis | | 1 1.0|
Mediastinal, Ectasia | | 1 1.0|
Mediastinal, Inflammation, Acute | | 1 1.0|
Mediastinal, Pigmentation | 3 2 | 5 1.8|
Pancreatic, Angiectasis | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + | 56 |
Angiectasis | | 4 1.5|
Ectasia | | 2 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Inflammation, Acute | | 1 2.0|
Pigmentation | | 2 2.0|
Lymphatic, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | | 3 1.3|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Fibrosis | 2 | 4 1.5|
Hematopoietic Cell Proliferation | 3 | 8 2.9|
Pigmentation, Hemosiderin | | 1 2.0|
Pigmentation | 2 3 2 | 13 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + M | 51 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| | |
| 5| 6| 6| 5| 5| 5| 5| 4| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + | 52 |
Galactocele | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Cyst Epithelial Inclusion | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 50 |
Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 3.0|
Edema | | 1 1.0|
Hemorrhage, Focal | 1 | 1 1.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 11 1.5|
Inflammation, Chronic | | 1 2.0|
Mineralization | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Alveolus, Foreign Body | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Interstitium, Inflammation, Chronic | | |
Active | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | 2 2 2 2 2 2 1 2 1 2 | 50 2.0|
Fungus | 2 2 3 3 2 2 2 3 3 | 46 2.3|
Inflammation, Acute | 3 3 3 3 3 3 3 2 3 3 | 59 2.7|
Respiratory Epithelium, Hyperplasia | 2 3 3 2 3 3 2 2 3 2 | 48 2.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 1 2 2 3 3 3 3 | 39 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| | |
| 5| 6| 6| 5| 5| 5| 5| 4| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Degeneration, Hyaline | | 1 3.0|
Nephropathy | 2 1 2 1 2 2 3 1 2 1 | 56 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Calculus Gross Observation | | 4 |
Calculus Micro Observation Only | | 4 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 1| 6| 7| 7| 7| 7| 3| 7| 4| 7| 7| 3| 4| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 6| 1| 3| 3| 3| 3| 4| 3| 6| 3| 3| 2| 6| 3| 1| 3| 3| 3| 3| 3| 6| 3| 3|
| 3| 3| 5| 3| 3| 4| 4| 4| 0| 4| 1| 3| 3| 9| 2| 3| 0| 3| 3| 3| 4| 3| 2| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MLK/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + M + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X 1 X X X X X X X X X|
Eosinophilic Focus | X X|
Fatty Change, Diffuse | 1 |
Fatty Change, Focal | 1 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | |
Mixed Cell Focus | X |
Necrosis | 1 2 |
__________________________________________________________________________|
Mesentery | + + + |
Abscess | 4 |
Artery, Inflammation, Chronic Active | |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 1 2 2 2 2 2 3 2 2 2 2 1|
Acinus, Hyperplasia | 2 2 3 2 1 2 4 2 3 2 2 3|
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 1 1 1 1 1 1 1 |
Hyperplasia, Basal Cell | 1 1 1 1 1 2 1 1 1 1 1 |
Inflammation, Chronic | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Lymphoid | |
Hyperplasia | 3 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 3 2 2 2 2 3 3 3 2 2 2 2 2 1 2 2 2 3 2|
Atrium, Dilatation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 1| 6| 7| 7| 7| 7| 3| 7| 4| 7| 7| 3| 4| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 6| 1| 3| 3| 3| 3| 4| 3| 6| 3| 3| 2| 6| 3| 1| 3| 3| 3| 3| 3| 6| 3| 3|
| 3| 3| 5| 3| 3| 4| 4| 4| 0| 4| 1| 3| 3| 9| 2| 3| 0| 3| 3| 3| 4| 3| 2| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MLK/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + M + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Oral, Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 |
Cyst | 2 |
Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + |
Inguinal, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Angiectasis | 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 |
Mediastinal, Infiltration Cellular, | |
Polymorphonuclear | 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 1| 6| 7| 7| 7| 7| 3| 7| 4| 7| 7| 3| 4| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 6| 1| 3| 3| 3| 3| 4| 3| 6| 3| 3| 2| 6| 3| 1| 3| 3| 3| 3| 3| 6| 3| 3|
| 3| 3| 5| 3| 3| 4| 4| 4| 0| 4| 1| 3| 3| 9| 2| 3| 0| 3| 3| 3| 4| 3| 2| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MLK/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 2 3 3 2 |
Infarct | 1 |
__________________________________________________________________________|
Thymus | + + + M + M + + + + + + + + + M + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Subcutaneous Tissue, Granuloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 1 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Acute | 3 |
Alveolar Epithelium, Hyperplasia | 1 |
Bronchiole, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Fungus | 2 2 1 3 3 1 2 2 2 2 3 1 2 2 1 1|
Inflammation, Acute | 3 3 1 3 3 2 3 3 3 3 3 3 3 2 3 2 3 3 3 3 2 3 2 3 2|
Respiratory Epithelium, Hyperplasia | 3 3 3 3 3 3 2 2 2 3 3 2 2 2 2 2 3 3 2 3 3|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 2 2 1 2 1 1 2 2 2 1 2 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 1| 6| 7| 7| 7| 7| 3| 7| 4| 7| 7| 3| 4| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 6| 1| 3| 3| 3| 3| 4| 3| 6| 3| 3| 2| 6| 3| 1| 3| 3| 3| 3| 3| 6| 3| 3|
| 3| 3| 5| 3| 3| 4| 4| 4| 0| 4| 1| 3| 3| 9| 2| 3| 0| 3| 3| 3| 4| 3| 2| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MLK/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 4| 5|
DAY ON TEST | 7| 6| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 3| 6| 5|
| 2| 1| 3| 3| 3| 3| 3| 3| 2| 1| 2| 3| 3| 2| 3| 5| 2| 2| 5| 4| 1| 5| 2| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MLK/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X |
Eosinophilic Focus | X X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 1 1 |
Hepatodiaphragmatic Nodule | |
Hyperplasia | |
Mixed Cell Focus | |
Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Abscess | |
Artery, Inflammation, Chronic Active | |
Fat, Necrosis | 2 4 3 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 2 2 2 1 2 1 1 2 1 1 2 1 1 1 1 3 2 |
Acinus, Hyperplasia | 2 1 3 2 3 1 3 1 4 3 4 2 4 2 2 1|
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 2 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 1 1 1 1 1 1 1 3|
Hyperplasia, Basal Cell | 1 1 1 1 1 1 1 1 2 2 3|
Inflammation, Chronic | 4|
Ulcer | 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | |
Metaplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 3 3 2 2 2 2 2 2 2 2 2 2 3 2 2|
Atrium, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 4| 5|
DAY ON TEST | 7| 6| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 3| 6| 5|
| 2| 1| 3| 3| 3| 3| 3| 3| 2| 1| 2| 3| 3| 2| 3| 5| 2| 2| 5| 4| 1| 5| 2| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MLK/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + M M + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 1 1 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Oral, Hyperplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Abscess | 2 2 |
Cyst | |
Dilatation | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + M + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1 2 |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Inguinal, Infiltration Cellular, | |
Plasma Cell | 3 |
Mediastinal, Angiectasis | 2 1 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Infiltration Cellular, | |
Polymorphonuclear | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 4| 5|
DAY ON TEST | 7| 6| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 3| 6| 5|
| 2| 1| 3| 3| 3| 3| 3| 3| 2| 1| 2| 3| 3| 2| 3| 5| 2| 2| 5| 4| 1| 5| 2| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MLK/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 3|
Infarct | 2 |
__________________________________________________________________________|
Thymus | + + M M + + + + + + + + + + M + + + + + + + + + M|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M M + + M + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Subcutaneous Tissue, Granuloma | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3|
Fibrosis | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 2 1 |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | 2 3 |
Bronchiole, Metaplasia, Squamous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2|
Fungus | 1 2 2 1 1 1 1 3 3 2 3 1 1 2 2 2 2 1|
Inflammation, Acute | 2 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 3 3 3 3 3|
Respiratory Epithelium, Hyperplasia | 3 2 2 2 3 3 2 3 2 2 2 3 3 2 3 3 3 2 3 2 2 3 2 2 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 2 2 1 2 2 2 3 2 1 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 4| 5|
DAY ON TEST | 7| 6| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 3| 6| 5|
| 2| 1| 3| 3| 3| 3| 3| 3| 2| 1| 2| 3| 3| 2| 3| 5| 2| 2| 5| 4| 1| 5| 2| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MLK/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy | 1 1 2 1 2 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X X |
Calculus Micro Observation Only | X |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 6| 2| 3| 3| 3| 3| 3| 3| 5| 3| | |
| 1| 1| 2| 3| 3| 3| 2| 3| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5.0 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MLK/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + | 58 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X | 41 |
Clear Cell Focus | X X X | 25 1.0|
Eosinophilic Focus | | 4 |
Fatty Change, Diffuse | | 1 1.0|
Fatty Change, Focal | 2 1 1 | 7 1.1|
Hepatodiaphragmatic Nodule | X | 2 |
Hyperplasia | 2 | 1 2.0|
Mixed Cell Focus | X | 2 |
Necrosis | | 4 1.3|
__________________________________________________________________________|____________|
Mesentery | + + | 11 |
Abscess | | 1 4.0|
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
Fat, Necrosis | 1 | 9 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Atrophy | 2 2 2 2 2 2 | 41 1.7|
Acinus, Hyperplasia | 2 2 2 2 4 | 33 2.4|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Metaplasia, Squamous | 1 | 10 1.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | 1 1 1 | 20 1.1|
Hyperplasia, Basal Cell | 1 1 2 1 | 26 1.2|
Inflammation, Chronic | | 1 4.0|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Erosion | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia | | 1 3.0|
Metaplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 6| 2| 3| 3| 3| 3| 3| 3| 5| 3| | |
| 1| 1| 2| 3| 3| 3| 2| 3| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5.0 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MLK/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 2 2 2 1 2 2 | 49 2.1|
Atrium, Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia | | 4 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + M + + | 59 |
Hyperplasia | 2 1 1 | 16 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 4 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + M + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Angiectasis | 2 3 | 3 2.7|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 1 | 11 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + | 58 |
C-Cell, Hyperplasia | | 9 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Oral, Hyperplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
Abscess | 2 | 4 1.8|
Cyst | | 1 2.0|
Dilatation | | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + M + + | 58 |
Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
Interstitial Cell, Hyperplasia | 1 1 | 6 1.3|
Seminiferous Tubule, Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 6| 2| 3| 3| 3| 3| 3| 3| 5| 3| | |
| 1| 1| 2| 3| 3| 3| 2| 3| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5.0 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MLK/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 18 |
Inguinal, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
Mediastinal, Angiectasis | | 3 1.7|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + M + + + | 57 |
Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Angiectasis | | 2 1.5|
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + | 58 |
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | | 6 2.7|
Infarct | 3 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + + | 51 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + M | 53 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
Subcutaneous Tissue, Granuloma | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 6| 2| 3| 3| 3| 3| 3| 3| 5| 3| | |
| 1| 1| 2| 3| 3| 3| 2| 3| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5.0 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MLK/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Congestion | | 2 3.0|
Fibrosis | | 1 1.0|
Hemorrhage | 1 | 2 1.5|
Infiltration Cellular, Histiocyte | 2 | 5 1.6|
Inflammation, Acute | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Bronchiole, Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | 2 2 2 2 2 2 2 2 2 | 48 2.0|
Fungus | 2 1 1 1 3 2 2 | 41 1.8|
Inflammation, Acute | 3 3 3 3 3 3 3 3 3 3 | 60 2.8|
Respiratory Epithelium, Hyperplasia | 2 2 1 2 2 3 3 2 3 2 | 56 2.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 2 2 1 | 34 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | X | 3 |
Nephropathy | 1 1 1 1 1 3 1 1 1 | 50 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Calculus Gross Observation | | 3 |
Calculus Micro Observation Only | | 2 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 2| 2| 2| 6| 2| 6| 6| 2| 2| 2| 2| 1| 2| 2| 2| 1| 0| 2| 2| 2|
| 2| 2| 2| 1| 2| 9| 9| 6| 2| 9| 1| 1| 9| 9| 9| 9| 8| 9| 9| 4| 3| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10.0 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + M + + + +|
Submucosa, Edema | 3 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + A + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X X|
Eosinophilic Focus | X |
Fatty Change, Diffuse | 2 2 1 |
Fatty Change, Focal | 1 2 1 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 2 |
Mixed Cell Focus | X X |
Necrosis | 1 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +|
Acinus, Atrophy | 3 1 1 1 2 2 2 1 1 1 2 1 1 3 1 1 1 2 1|
Acinus, Hyperplasia | 4 4 3 2 2 4 3 1 1 1 2 1 3 1 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Duct, Metaplasia, Squamous | 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 |
Hyperplasia, Basal Cell | 1 2 1 1 3 2 1 1 1 2 1 1 |
Ulcer | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Erosion | 2 |
Hemorrhage | |
Mineralization | |
__________________________________________________________________________|
Tongue | +|
Hyperkeratosis | 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 3 2 2 2 2 1 2 2 3 2 3 2 3 2 2 2 2 2 2 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 2| 2| 2| 6| 2| 6| 6| 2| 2| 2| 2| 1| 2| 2| 2| 1| 0| 2| 2| 2|
| 2| 2| 2| 1| 2| 9| 9| 6| 2| 9| 1| 1| 9| 9| 9| 9| 8| 9| 9| 4| 3| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10.0 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | 1 1 2 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Congestion | 3 |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 1 1 2 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + I + + + A + + + + + + + +|
Abscess | 1 |
Cyst | X |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 3 1 2 2 |
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Angiectasis | |
Pancreatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 2| 2| 2| 6| 2| 6| 6| 2| 2| 2| 2| 1| 2| 2| 2| 1| 0| 2| 2| 2|
| 2| 2| 2| 1| 2| 9| 9| 6| 2| 9| 1| 1| 9| 9| 9| 9| 8| 9| 9| 4| 3| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10.0 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
Lymphatic, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Developmental Malformation | X |
Hematocyst | 2 |
Hematopoietic Cell Proliferation | 2 2 |
Pigmentation | |
Lymphoid Follicle, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + M + + M +|
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + M M + + + + A + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
Foot, Acanthosis | 3 |
Foot, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + A + + + + + + + +|
Congestion | 3 4 |
Edema | 1 |
Inflammation, Acute | 3 |
Alveolar Epithelium, Hyperplasia | 1 1 |
Mediastinum, Abscess | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 3 2 2 2 2 2 2 2 3 3 2 2 2 2 2 2 2 2 2 2|
Fungus | 2 2 2 2 1 2 2 3 2 3 2 1 2 2 3 1 2 2 3 |
Inflammation, Acute | 3 3 2 3 2 3 3 2 2 3 3 3 3 2 3 2 2 2 3 3 3 2 3 3 3|
Respiratory Epithelium, Hyperplasia | 3 3 3 3 3 3 2 2 3 1 3 3 3 2 2 2 3 2 2 1 3 3 2|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 2| 2| 2| 6| 2| 6| 6| 2| 2| 2| 2| 1| 2| 2| 2| 1| 0| 2| 2| 2|
| 2| 2| 2| 1| 2| 9| 9| 6| 2| 9| 1| 1| 9| 9| 9| 9| 8| 9| 9| 4| 3| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10.0 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 1 1 1 1 2 1 3 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Eye | + + |
Inflammation, Chronic Active | 4 |
Lens, Cataract | 3 |
Retina, Atrophy | 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + A + + + + + + + + A + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + M + + + + + + A + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 4| 5| 7| 6|
DAY ON TEST | 6| 2| 3| 3| 3| 2| 4| 0| 1| 9| 2| 2| 6| 2| 2| 2| 2| 2| 6| 6| 2| 6| 8| 2| 7|
| 2| 9| 2| 2| 2| 2| 7| 7| 7| 1| 9| 9| 1| 9| 9| 9| 9| 9| 1| 1| 9| 2| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Submucosa, Edema | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X X X |
Eosinophilic Focus | |
Fatty Change, Diffuse | 2 1 1 |
Fatty Change, Focal | 1 1 1 2 1|
Hepatodiaphragmatic Nodule | X |
Hyperplasia | |
Mixed Cell Focus | X X |
Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 1 1 1 1 2 1 2 1 2 1 1 1 1 2 2|
Acinus, Hyperplasia | 1 2 1 1 2 3 2 2 3 1 1 4 3 1 1 4 2 2|
Artery, Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Duct, Metaplasia, Squamous | 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 1 1 1 1 1 1 2 1|
Hyperplasia, Basal Cell | 1 1 1 1 2 1 1 1 2 1|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hemorrhage | 4 |
Mineralization | 1 |
__________________________________________________________________________|
Tongue | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 3 1 2 2 1 2 1 2 2 1 2 2 2 2 2 2|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 4| 5| 7| 6|
DAY ON TEST | 6| 2| 3| 3| 3| 2| 4| 0| 1| 9| 2| 2| 6| 2| 2| 2| 2| 2| 6| 6| 2| 6| 8| 2| 7|
| 2| 9| 2| 2| 2| 2| 7| 7| 7| 1| 9| 9| 1| 9| 9| 9| 9| 9| 1| 1| 9| 2| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 2 2 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + M + + + + + + + + + M M M|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Pars Distalis, Angiectasis | 2 3 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 1 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 1 2 1 1 2 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 2 |
Cyst | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 3 2 2 2 2 2 |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Angiectasis | 1 |
Pancreatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 1 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 4| 5| 7| 6|
DAY ON TEST | 6| 2| 3| 3| 3| 2| 4| 0| 1| 9| 2| 2| 6| 2| 2| 2| 2| 2| 6| 6| 2| 6| 8| 2| 7|
| 2| 9| 2| 2| 2| 2| 7| 7| 7| 1| 9| 9| 1| 9| 9| 9| 9| 9| 1| 1| 9| 2| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 |
Lymphatic, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Developmental Malformation | |
Hematocyst | |
Hematopoietic Cell Proliferation | 2 3 |
Pigmentation | 3|
Lymphoid Follicle, Atrophy | 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + M + + + + + + + + + + + M + +|
Epithelial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + M + + + + + + + M + + + M|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Foot, Acanthosis | |
Foot, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | |
Mediastinum, Abscess | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 3 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2|
Fungus | 2 2 3 3 1 1 3 2 2 1 3 1 2 1 1|
Inflammation, Acute | 3 3 3 3 2 3 1 3 3 2 3 2 3 2 3 2 3 3 4 2 3 3 3 3|
Respiratory Epithelium, Hyperplasia | 2 2 3 3 2 2 3 3 1 3 2 3 3 2 3 3 2 3 3 3|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 4| 5| 7| 6|
DAY ON TEST | 6| 2| 3| 3| 3| 2| 4| 0| 1| 9| 2| 2| 6| 2| 2| 2| 2| 2| 6| 6| 2| 6| 8| 2| 7|
| 2| 9| 2| 2| 2| 2| 7| 7| 7| 1| 9| 9| 1| 9| 9| 9| 9| 9| 1| 1| 9| 2| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
ML/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 1 1 1 2 1 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Eye | |
Inflammation, Chronic Active | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X X |
Calculus Micro Observation Only | X X |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| | |
| 7| 3| 2| 2| 2| 2| 2| 2| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10.0 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A | 56 |
Submucosa, Edema | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + A | 55 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A | 56 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X X X X X X X | 42 |
Clear Cell Focus | X X X X X X X X | 35 |
Eosinophilic Focus | X | 2 |
Fatty Change, Diffuse | | 6 1.5|
Fatty Change, Focal | 1 | 10 1.2|
Hepatodiaphragmatic Nodule | | 2 |
Hyperplasia | | 1 2.0|
Mixed Cell Focus | X X | 6 |
Necrosis | 2 | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + + | 7 |
Fat, Inflammation, Chronic Active | 2 | 1 2.0|
Fat, Necrosis | 1 3 3 | 6 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Atrophy | 2 2 1 1 1 2 1 | 43 1.4|
Acinus, Hyperplasia | 2 2 4 3 3 | 37 2.2|
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Acute | | 1 1.0|
Duct, Metaplasia, Squamous | 1 1 1 | 13 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | 1 1 1 1 1 1 | 24 1.0|
Hyperplasia, Basal Cell | 1 1 3 1 1 1 1 | 29 1.3|
Ulcer | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Erosion | 2 | 2 2.0|
Hemorrhage | | 1 4.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hyperkeratosis | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| | |
| 7| 3| 2| 2| 2| 2| 2| 2| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10.0 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 2 2 1 2 2 2 | 51 2.0|
Inflammation, Chronic | 4 | 1 4.0|
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
Hyperplasia | 2 1 1 1 3 | 19 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
Hyperplasia | 2 | 5 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M M M + + | 51 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Congestion | | 1 3.0|
Pars Distalis, Angiectasis | 2 2 | 5 2.4|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 1 1 2 | 10 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + A | 58 |
C-Cell, Hyperplasia | 2 2 1 | 19 1.6|
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Abscess | 2 1 | 5 1.6|
Cyst | | 1 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | 1 | 11 2.0|
Seminiferous Tubule, Atrophy | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| | |
| 7| 3| 2| 2| 2| 2| 2| 2| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10.0 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + | 8 |
Mediastinal, Angiectasis | 2 2 | 3 1.7|
Pancreatic, Angiectasis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + | 59 |
Congestion | 3 | 1 3.0|
Ectasia | | 1 1.0|
Hyperplasia, Lymphoid | | 1 2.0|
Lymphatic, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Depletion Lymphoid | | 1 2.0|
Developmental Malformation | | 1 |
Hematocyst | | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 | 6 2.3|
Pigmentation | 3 | 2 3.0|
Lymphoid Follicle, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M M | 52 |
Epithelial Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + | 51 |
Galactocele | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Hyperkeratosis | | 1 4.0|
Foot, Acanthosis | | 1 3.0|
Foot, Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 51 |
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05144-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SAFFLOWER OIL Date: 04/25/97
Route: GAVAGE Time: 08:19:21
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| | |
| 7| 3| 2| 2| 2| 2| 2| 2| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10.0 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
ML/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Congestion | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Congestion | | 2 3.5|
Edema | | 1 1.0|
Inflammation, Acute | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 1.3|
Mediastinum, Abscess | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | 2 2 2 2 2 2 2 2 2 2 | 51 2.1|
Fungus | 2 2 2 2 2 1 2 | 41 2.0|
Inflammation, Acute | 2 3 2 2 3 2 3 3 1 3 | 59 2.6|
Respiratory Epithelium, Hyperplasia | 2 3 3 3 3 3 3 3 2 1 | 53 2.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 2 2 2 2 1 2 2 | 29 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Eye | | 2 |
Inflammation, Chronic Active | | 1 4.0|
Lens, Cataract | | 1 3.0|
Retina, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 | 55 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Calculus Gross Observation | | 3 |
Calculus Micro Observation Only | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
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---------- END OF REPORT ----------
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