TDMS Study 05144-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/17/94
EXP: 05144 SAFFLOWER OIL TIME: 19:57:17
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 62204
CONT: N01-ES-55123 CAS: 8001-23-8
PATHOLOGIST: K. MURTHY S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/17/94
EXP: 05144 SAFFLOWER OIL TIME: 19:57:17
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 62204
CONT: N01-ES-55123 CAS: 8001-23-8
PATHOLOGIST: K. MURTHY S. EUSTIS
SAFFLOWER OIL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 ML/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 457 476 601 610 613 627 635 641 647 661 |
| 671 672 684 691 692 692 692 708 710 715 |
| CENSORED DEATHS |
| 461 461 461 461 462 462 462 462 462 462 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5 MLKG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 388 398 485 491 600 614 615 618 624 634 |
| 634 679 683 693 708 710 727 |
| CENSORED DEATHS |
| 461 461 461 461 461 462 462 462 462 462 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5.0 MLKG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 10 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 165 329 340 531 554 610 613 655 672 721 |
| CENSORED DEATHS |
| 461 461 461 461 461 462 462 462 462 462 |
| |
==================================================================================
SAFFLOWER OIL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 10.0 ML/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 9 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 302 547 582 607 613 617 627 633 672 691 |
| 715 718 722 724 726 |
| CENSORED DEATHS |
| 461 461 461 461 461 461 462 462 462 |
| |
==================================================================================
SAFFLOWER OIL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 ML/KG | 100.0 100.0 100.0 100.0 100.0 96.3 96.3 94.3 80.3 60.2 |
| | |
| | |
|2.5 MLKG | 100.0 100.0 100.0 100.0 96.7 94.7 92.6 90.6 78.5 66.5 |
| | |
| | |
|5.0 MLKG | 100.0 98.3 98.3 95.0 95.0 95.0 93.0 91.0 84.9 80.9 |
| | |
| | |
|10.0 | 100.0 100.0 100.0 98.3 98.3 98.3 98.3 94.4 84.6 70.8 |
|ML/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 ML/KG 2.5 MLKG 5.0 MLKG 10.0 |
| ML/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.2% 66.5% 80.9% 70.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.182N P=0.756N P=0.075N P=0.341N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 644.8 605.9 519.0 633.1 |
|NATURAL DEATHS (C) | (15.7) (25.4) (57.2) (28.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 656.4 649.6 649.4 664.9 |
|(STANDARD ERROR) | (13.4) (14.7) (17.4) (14.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SAFFLOWER OIL
KAPLAN-MEIER SURVIVAL CURVES
0 ML/KG = 1
2.5 MLKG = 2
5.0 MLKG = 3
10.0 ML/KG = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 4 2 1
| 3 4 3 22 1 1 4
|
| 3 3 2 1 2 4 4 1
95 + 3 22 3 4 4
| 1 1
| 2 3 3 244
| 3 2 2
P 90 + 141
E | 411
R | 3 3
C | 22411
E 85 + 224 3 3
N | 11
T | 22 1 13 4 3
| 4 3 3
S 80 + 11
U | 2 2
R |
V | 121 44
I 75 + 22
V | 11
A | 2 2
L | 4 4
70 +
| 2 2
|
| 1 1 2 2
65 +
|
| 11
|
60 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.