TDMS Study 05145-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
TRICAPRYLIN
NTP Experiment-Test: 05145-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/17/94
Route: GAVAGE Time: 20:48:00
Facility: TSI Mason Research
Chemical CAS #: 538-23-8
Lock Date: 12/26/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05145-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICAPRYLIN Date: 09/17/94
Route: GAVAGE Time: 20:48:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 2.5 MLKG 5.0 MLKG 10.0
ML/KG
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DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 7
Early Deaths
Moribund Sacrifice 15 13 15 17
Natural Death 4 7 4 13
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 29 30 30 22
Natural Death 2 1
Animals Examined Microscopically 60 60 60 60
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ALIMENTARY SYSTEM
Esophagus (58) (58) (60) (59)
Intestine Large, Colon (57) (56) (58) (51)
Adenocarcinoma 1 (2%)
Polyp Adenomatous 1 (2%)
Intestine Large, Rectum (58) (56) (58) (51)
Circumanal Gland, Adenoma 1 (2%)
Intestine Large, Cecum (57) (55) (58) (49)
Intestine Small, Duodenum (59) (56) (58) (49)
Intestine Small, Jejunum (56) (56) (57) (47)
Adenocarcinoma 1 (2%)
Intestine Small, Ileum (56) (56) (58) (49)
Leiomyosarcoma 1 (2%)
Liver (60) (60) (60) (58)
Hepatocellular Adenoma 1 (2%) 3 (5%) 4 (7%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mesentery (9) (14) (4) (6)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (25%)
Pancreas (59) (59) (59) (57)
Acinus, Adenoma 2 (3%) 5 (8%) 11 (19%) 8 (14%)
Acinus, Adenoma, Multiple 1 (2%) 2 (3%) 11 (19%)
Pharynx (1) (1)
Palate, Squamous Cell Carcinoma 1 (100%)
Salivary Glands (60) (59) (58) (58)
Stomach, Forestomach (60) (60) (59) (59)
Squamous Cell Papilloma 3 (5%) 8 (14%)
Squamous Cell Papilloma, Multiple 2 (3%)
Stomach, Glandular (60) (58) (59) (57)
Tongue (2) (1)
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NTP Experiment-Test: 05145-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICAPRYLIN Date: 09/17/94
Route: GAVAGE Time: 20:48:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 2.5 MLKG 5.0 MLKG 10.0
ML/KG
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ALIMENTARY SYSTEM - cont
Squamous Cell Papilloma 2 (100%)
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CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Leiomyoma 1 (100%)
Vena Cava, Chemodectoma Benign 1 (100%)
Heart (60) (60) (59) (58)
Adenocarcinoma, Metastatic, Uncertain
Primary Site 1 (2%)
Schwannoma Malignant 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Cortex (60) (59) (59) (58)
Adenoma 1 (2%)
Adrenal Medulla (60) (59) (59) (58)
Pheochromocytoma Malignant 2 (3%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 10 (17%) 9 (15%) 13 (22%) 7 (12%)
Bilateral, Pheochromocytoma Benign 1 (2%) 2 (3%) 3 (5%) 7 (12%)
Islets, Pancreatic (59) (58) (59) (56)
Adenoma 3 (5%) 2 (3%) 3 (5%) 1 (2%)
Carcinoma 2 (3%)
Pituitary Gland (60) (57) (59) (58)
Pars Distalis, Adenoma 8 (13%) 8 (14%) 5 (8%) 4 (7%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (57) (56) (59) (54)
C-Cell, Adenoma 6 (11%) 7 (13%) 9 (15%) 2 (4%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
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GENERAL BODY SYSTEM
Peritoneum (1)
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GENITAL SYSTEM
Epididymis (59) (60) (60) (59)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
Preputial Gland (59) (58) (60) (58)
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NTP Experiment-Test: 05145-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICAPRYLIN Date: 09/17/94
Route: GAVAGE Time: 20:48:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 2.5 MLKG 5.0 MLKG 10.0
ML/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Adenoma 6 (10%) 4 (7%) 6 (10%) 2 (3%)
Carcinoma 1 (2%) 1 (2%)
Bilateral, Adenoma 1 (2%) 1 (2%)
Prostate (59) (59) (59) (59)
Seminal Vesicle (59) (60) (60) (59)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
Testes (59) (60) (60) (59)
Bilateral, Interstitial Cell, Adenoma 47 (80%) 44 (73%) 49 (82%) 37 (63%)
Interstitial Cell, Adenoma 10 (17%) 9 (15%) 10 (17%) 12 (20%)
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HEMATOPOIETIC SYSTEM
Blood (11) (11) (7) (2)
Bone Marrow (60) (59) (60) (60)
Lymph Node (25) (25) (25) (16)
Lumbar, Leiomyosarcoma, Metastatic,
Intestine Small, Ileum 1 (4%)
Mediastinal, Osteosarcoma, Metastatic, Bone 1 (4%)
Lymph Node, Mandibular (59) (56) (59) (57)
Fibrosarcoma, Metastatic, Ear 1 (2%)
Lymph Node, Mesenteric (58) (59) (60) (55)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
Spleen (59) (60) (59) (58)
Hemangiosarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Thymus (56) (55) (56) (53)
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INTEGUMENTARY SYSTEM
Mammary Gland (51) (48) (47) (47)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Fibroadenoma 5 (10%) 2 (4%) 3 (6%) 2 (4%)
Skin (59) (59) (58) (59)
Basal Cell Adenoma 1 (2%)
Keratoacanthoma 2 (3%) 1 (2%) 3 (5%)
Schwannoma Malignant 1 (2%)
Squamous Cell Papilloma 4 (7%) 2 (3%) 2 (3%) 1 (2%)
Trichoepithelioma 1 (2%)
Pinna, Schwannoma Malignant 1 (2%)
Subcutaneous Tissue, Fibroma 3 (5%) 2 (3%) 3 (5%) 1 (2%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
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NTP Experiment-Test: 05145-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICAPRYLIN Date: 09/17/94
Route: GAVAGE Time: 20:48:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 2.5 MLKG 5.0 MLKG 10.0
ML/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Neurofibroma 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 2 (3%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
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MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Osteosarcoma 1 (2%) 1 (2%)
Vertebra, Chordoma 1 (2%)
Skeletal Muscle (50) (50) (47) (53)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
Sarcoma 1 (2%)
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NERVOUS SYSTEM
Brain (60) (60) (59) (60)
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RESPIRATORY SYSTEM
Lung (60) (60) (60) (58)
Alveolar/Bronchiolar Adenoma 2 (3%) 2 (3%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinosarcoma 1 (2%)
Fibrosarcoma, Metastatic, Ear 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mediastinum, Leiomyosarcoma, Metastatic,
Intestine Small, Ileum 1 (2%)
Nose (60) (59) (60) (59)
Chondroma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
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SPECIAL SENSES SYSTEM
Ear (1)
Fibrosarcoma 1 (100%)
Eye (1) (1) (3)
Harderian Gland (1)
Zymbal's Gland (1)
Carcinoma 1 (100%)
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Page 5
NTP Experiment-Test: 05145-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICAPRYLIN Date: 09/17/94
Route: GAVAGE Time: 20:48:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 2.5 MLKG 5.0 MLKG 10.0
ML/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (56)
Carcinoma 1 (2%)
Urinary Bladder (58) (57) (58) (55)
Transitional Epithelium, Carcinoma 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
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SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia Mononuclear 23 (38%) 29 (48%) 23 (38%) 9 (15%)
Lymphoma Malignant Histiocytic 1 (2%) 1 (2%)
Mesothelioma Malignant 5 (8%) 2 (3%) 2 (3%) 3 (5%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05145-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRICAPRYLIN Date: 09/17/94
Route: GAVAGE Time: 20:48:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 2.5 MLKG 5.0 MLKG 10.0
ML/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 58 57 59 49
Total Primary Neoplasms 151 146 172 131
Total Animals with Benign Neoplasms 57 54 59 49
Total Benign Neoplasms 115 104 138 111
Total Animals with Malignant Neoplasms 34 37 30 18
Total Malignant Neoplasms 36 42 34 20
Total Animals with Metastatic Neoplasms 6 5 4 3
Total Metastatic Neoplasm 29 12 25 15
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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