TDMS Study 05150-02 Pathology Tables
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 Facility: TSI Mason Research Chemical CAS #: 298-59-9 Lock Date: 02/19/92 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 4| 4| 7| 2| 0| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 4| 7| 4| 2| 7| 7| 2| 4| 7| DAY ON TEST | 5| 5| 4| 8| 6| 2| 4| 4| 4| 4| 5| 5| 4| 4| 7| 4| 5| 4| 5| 8| 4| 4| 8| 5| 4| | 6| 5| 7| 1| 7| 8| 6| 7| 7| 7| 5| 5| 7| 6| 3| 7| 5| 7| 6| 0| 7| 7| 0| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + A + + + + + + + + A + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + M + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + M + + + + + + + + + + + + + +| Polyp Adenomatous | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + A + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + A + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | Hemangiosarcoma | | Hepatocellular Carcinoma | X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X | Hepatocellular Adenoma, Multiple | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Mesentery | +| Sarcoma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Adrenal Medulla | M + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | M M + M M + + M + + M M M M + + M + + M + + M + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 4| 4| 7| 2| 0| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 4| 7| 4| 2| 7| 7| 2| 4| 7| DAY ON TEST | 5| 5| 4| 8| 6| 2| 4| 4| 4| 4| 5| 5| 4| 4| 7| 4| 5| 4| 5| 8| 4| 4| 8| 5| 4| | 6| 5| 7| 1| 7| 8| 6| 7| 7| 7| 5| 5| 7| 6| 3| 7| 5| 7| 6| 0| 7| 7| 0| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + I + + + + + + + +| Pars Distalis, Adenoma | X X | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Hemangiosarcoma | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + + + + + + + + + + M +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + M + + + + M + + + + + +| Cystadenoma | X | Teratoma NOS | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Histiocytic Sarcoma | X | Leiomyoma | X | Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Iliac, Lymphoma Malignant Mixed | | Lumbar, Lymphoma Malignant Mixed | X | Mediastinal, Lymphoma Malignant Mixed| | Pancreatic, Lymphoma Malignant Mixed | X | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + M + M M + + + + + + + + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + M + M + + + + + + M + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 4| 4| 7| 2| 0| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 4| 7| 4| 2| 7| 7| 2| 4| 7| DAY ON TEST | 5| 5| 4| 8| 6| 2| 4| 4| 4| 4| 5| 5| 4| 4| 7| 4| 5| 4| 5| 8| 4| 4| 8| 5| 4| | 6| 5| 7| 1| 7| 8| 6| 7| 7| 7| 5| 5| 7| 6| 3| 7| 5| 7| 6| 0| 7| 7| 0| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + M + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Harderian Gland | + | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Urinary Bladder | + + + + + A + + + + + + + + A + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 2| 7| 7| 5| 7| 3| 2| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| DAY ON TEST | 8| 4| 4| 7| 4| 4| 8| 4| 4| 4| 8| 4| 8| 0| 4| 0| 4| 4| 0| 2| 4| 8| 4| 4| 4| | 1| 7| 7| 1| 7| 8| 0| 7| 7| 7| 1| 7| 0| 8| 7| 8| 7| 7| 8| 1| 7| 5| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + A + + + + M + + + + + + + + + + + + A + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + A + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + A + + +| Polyp Adenomatous | | __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + A + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + A + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Hemangiosarcoma | X | Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | + | Sarcoma | | __________________________________________________________________________| Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + M + + M + M + M M I + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 2| 7| 7| 5| 7| 3| 2| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| DAY ON TEST | 8| 4| 4| 7| 4| 4| 8| 4| 4| 4| 8| 4| 8| 0| 4| 0| 4| 4| 0| 2| 4| 8| 4| 4| 4| | 1| 7| 7| 1| 7| 8| 0| 7| 7| 7| 1| 7| 0| 8| 7| 8| 7| 7| 8| 1| 7| 5| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| Pars Distalis, Adenoma | X X X | Pars Intermedia, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Hemangiosarcoma | X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + + M M + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + M M + + + + + +| Cystadenoma | X | Teratoma NOS | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Histiocytic Sarcoma | X | Leiomyoma | | Polyp Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + | Iliac, Lymphoma Malignant Mixed | X | Lumbar, Lymphoma Malignant Mixed | | Mediastinal, Lymphoma Malignant Mixed| X | Pancreatic, Lymphoma Malignant Mixed | | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + I + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + M + + + + M + + +| Lymphoma Malignant Mixed | X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + M + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Mixed | X X X X| __________________________________________________________________________| Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 2| 7| 7| 5| 7| 3| 2| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| DAY ON TEST | 8| 4| 4| 7| 4| 4| 8| 4| 4| 4| 8| 4| 8| 0| 4| 0| 4| 4| 0| 2| 4| 8| 4| 4| 4| | 1| 7| 7| 1| 7| 8| 0| 7| 7| 7| 1| 7| 0| 8| 7| 8| 7| 7| 8| 1| 7| 5| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Harderian Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X| __________________________________________________________________________| Urinary Bladder | + + + A + + + + + + + + + + + + + + + + M A + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X X X X| _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 4| 7| 4| 7| 2| 4| 2| 2| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 5| 4| 5| 4| 8| 5| 8| 8| 4| 4| 8| 8| 4| 4| 4| 4| 4| 4| 4| | | | 6| 7| 6| 7| 0| 5| 1| 1| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + | 68 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + | 64 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + | 66 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + | 65 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + | 67 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + | 65 | Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + | 65 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + | 65 | Lymphoma Malignant Mixed | X | 3 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + | 69 | Hemangioma | | 1 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | | 3 | Hepatocellular Carcinoma, Multiple | X | 2 | Hepatocellular Adenoma | X X | 5 | Hepatocellular Adenoma, Multiple | X X | 2 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X X | 5 | __________________________________________________________________________|____________| Mesentery | + + + + | 6 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + | 68 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + M + + + + + + + | 67 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | 68 | __________________________________________________________________________|____________| Tongue | | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + | 68 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + | 69 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 4| 7| 4| 7| 2| 4| 2| 2| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 5| 4| 5| 4| 8| 5| 8| 8| 4| 4| 8| 8| 4| 4| 4| 4| 4| 4| 4| | | | 6| 7| 6| 7| 0| 5| 1| 1| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + | 68 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + M M M M + + M M + + + + + + + | 43 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + | 67 | Pars Distalis, Adenoma | X X | 7 | Pars Intermedia, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + | 69 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 2 | Hemangiosarcoma | | 1 | Lymphoma Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + | 43 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + | 65 | Cystadenoma | | 2 | Teratoma NOS | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + | 69 | Hemangioma | X | 1 | Histiocytic Sarcoma | | 2 | Leiomyoma | | 1 | Polyp Stromal | | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Lymph Node | + + + | 7 | Iliac, Lymphoma Malignant Mixed | | 1 | Lumbar, Lymphoma Malignant Mixed | X | 2 | Mediastinal, Lymphoma Malignant Mixed| | 1 | Pancreatic, Lymphoma Malignant Mixed | | 1 | Renal, Lymphoma Malignant Mixed | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + | 67 | Lymphoma Malignant Mixed | X X X | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + | 65 | Lymphoma Malignant Mixed | X X X | 7 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + | 68 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 4| 7| 4| 7| 2| 4| 2| 2| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 5| 4| 5| 4| 8| 5| 8| 8| 4| 4| 8| 8| 4| 4| 4| 4| 4| 4| 4| | | | 6| 7| 6| 7| 0| 5| 1| 1| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hemangiosarcoma | | 2 | Lymphoma Malignant Mixed | X X X X | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + | 65 | Lymphoma Malignant Mixed | X X | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + M + + M + M + + + + M + M + + + | 59 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + | 69 | Lymphoma Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + | 69 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + | 68 | Alveolar/Bronchiolar Adenoma | | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + | 69 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Harderian Gland | + | 2 | Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + | 69 | Lymphoma Malignant Mixed | X X | 3 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + M + + + + + + + + + + | 63 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + | 69 | Histiocytic Sarcoma | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 4| 7| 4| 7| 2| 4| 2| 2| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 5| 4| 5| 4| 8| 5| 8| 8| 4| 4| 8| 8| 4| 4| 4| 4| 4| 4| 4| | | | 6| 7| 6| 7| 0| 5| 1| 1| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X X X X | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 2| 7| 7| 4| 4| 2| 7| 7| 7| 7| 2| 7| 0| 6| 2| 7| 7| 7| 4| 4| 4| DAY ON TEST | 9| 5| 4| 4| 8| 4| 4| 5| 5| 8| 4| 4| 4| 4| 8| 4| 1| 8| 8| 4| 4| 4| 6| 5| 5| | 9| 6| 3| 3| 1| 3| 3| 5| 5| 1| 3| 3| 3| 1| 0| 3| 2| 1| 1| 3| 3| 6| 2| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 50 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + + + + + + + + + M + + M + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | | Hepatocellular Adenoma | X X X X| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + I + + + + + + + + + + + + I + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + M M M + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + + M + + + + + + + | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X X | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 2| 7| 7| 4| 4| 2| 7| 7| 7| 7| 2| 7| 0| 6| 2| 7| 7| 7| 4| 4| 4| DAY ON TEST | 9| 5| 4| 4| 8| 4| 4| 5| 5| 8| 4| 4| 4| 4| 8| 4| 1| 8| 8| 4| 4| 4| 6| 5| 5| | 9| 6| 3| 3| 1| 3| 3| 5| 5| 1| 3| 3| 3| 1| 0| 3| 2| 1| 1| 3| 3| 6| 2| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 50 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Cystadenoma, Multiple | X | Lymphoma Malignant Lymphocytic | | Teratoma NOS | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node | + + | Lumbar, Lymphoma Malignant | | Lymphocytic | | Lumbar, Lymphoma Malignant Mixed | X | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant Mixed| | Pancreatic, Lymphoma Malignant Mixed | | Renal, Lymphoma Malignant Lymphocytic| | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + M + + + + M + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + + + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 2| 7| 7| 4| 4| 2| 7| 7| 7| 7| 2| 7| 0| 6| 2| 7| 7| 7| 4| 4| 4| DAY ON TEST | 9| 5| 4| 4| 8| 4| 4| 5| 5| 8| 4| 4| 4| 4| 8| 4| 1| 8| 8| 4| 4| 4| 6| 5| 5| | 9| 6| 3| 3| 1| 3| 3| 5| 5| 1| 3| 3| 3| 1| 0| 3| 2| 1| 1| 3| 3| 6| 2| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 50 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Lymphoma Malignant Mixed | | Osteosarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X X | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 2| 7| 7| 7| 6| 4| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 2| 7| 3| 4| 6| 1| 7| DAY ON TEST | 4| 8| 4| 4| 4| 2| 5| 8| 4| 4| 4| 4| 4| 4| 0| 4| 4| 0| 8| 4| 9| 5| 9| 5| 4| | 6| 1| 6| 6| 3| 5| 5| 8| 3| 6| 6| 6| 6| 6| 3| 6| 6| 3| 1| 6| 1| 5| 0| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 50 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + A + A + + + + + + A + + A + + + + + A +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + A + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + A + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + A + + + + + + + + + A + + + + + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + A + + + + + + A + + A + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + A + + + + + A +| Adenocarcinoma | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + A + + + + + + A + + A + + + + + A +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X | Hepatocellular Adenoma | X X X X | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | __________________________________________________________________________| Parathyroid Gland | + + + M + M + + + + + + + + + M + M + + M + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| Follicular Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + M + + + + + + + + + + + + M + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X X | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 2| 7| 7| 7| 6| 4| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 2| 7| 3| 4| 6| 1| 7| DAY ON TEST | 4| 8| 4| 4| 4| 2| 5| 8| 4| 4| 4| 4| 4| 4| 0| 4| 4| 0| 8| 4| 9| 5| 9| 5| 4| | 6| 1| 6| 6| 3| 5| 5| 8| 3| 6| 6| 6| 6| 6| 3| 6| 6| 3| 1| 6| 1| 5| 0| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 50 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Cystadenoma, Multiple | | Lymphoma Malignant Lymphocytic | X | Teratoma NOS | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node | + + | Lumbar, Lymphoma Malignant | | Lymphocytic | X | Lumbar, Lymphoma Malignant Mixed | | Mediastinal, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant Mixed| | Pancreatic, Lymphoma Malignant Mixed | X | Renal, Lymphoma Malignant Lymphocytic| X | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + M + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + A +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + + + + + + + M + + + M + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 2| 7| 7| 7| 6| 4| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 2| 7| 3| 4| 6| 1| 7| DAY ON TEST | 4| 8| 4| 4| 4| 2| 5| 8| 4| 4| 4| 4| 4| 4| 0| 4| 4| 0| 8| 4| 9| 5| 9| 5| 4| | 6| 1| 6| 6| 3| 5| 5| 8| 3| 6| 6| 6| 6| 6| 3| 6| 6| 3| 1| 6| 1| 5| 0| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 50 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Lymphoma Malignant Mixed | | Osteosarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Urinary Bladder | + + + + + A + A + + + + + + A + + A + + + + + A +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X X X | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 4| 4| 4| 6| 2| 7| 7| 7| 7| 7| 1| 7| 2| 2| 7| 7| 6| 7| | | DAY ON TEST | 4| 5| 5| 5| 2| 8| 4| 4| 4| 4| 4| 4| 4| 8| 8| 4| 4| 9| 3| | | | 6| 6| 6| 6| 8| 0| 6| 6| 6| 6| 6| 5| 6| 1| 0| 6| 6| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 50 PPM | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Gallbladder | + M M + A + + + + + + + + + + + + A + | 56 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + | 65 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + | 65 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + A + | 63 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + A + | 62 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + A + | 63 | Adenocarcinoma | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + A + | 61 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Liver | + + + + A + + + + + + + + + + + + + + | 67 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X | 3 | Hepatocellular Adenoma | X X X | 11 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Pancreas | + + + + A + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + M + + + + | 67 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | 68 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + A + + + + + + + + + + + + A + | 65 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + | 68 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + A + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + A + + + + + + + + + + + + + + | 64 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + | 67 | Adenoma | | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + M + M M M + + M M M M + + + + M M + | 48 | __________________________________________________________________________|____________| Pituitary Gland | + + M + + + + + M + + + + + + + + + + | 66 | Pars Distalis, Adenoma | X X | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + M + + + + + + + + + + + + + + + + | 66 | Follicular Cell, Adenoma | X X X X | 6 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 4| 4| 4| 6| 2| 7| 7| 7| 7| 7| 1| 7| 2| 2| 7| 7| 6| 7| | | DAY ON TEST | 4| 5| 5| 5| 2| 8| 4| 4| 4| 4| 4| 4| 4| 8| 8| 4| 4| 9| 3| | | | 6| 6| 6| 6| 8| 0| 6| 6| 6| 6| 6| 5| 6| 1| 0| 6| 6| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 50 PPM | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + | 41 | __________________________________________________________________________|____________| Ovary | + + + + A + + + + + + + + + + + + + + | 67 | Cystadenoma | | 4 | Cystadenoma, Multiple | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Teratoma NOS | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + | 68 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + | 68 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + + | 7 | Lumbar, Lymphoma Malignant | | | Lymphocytic | | 1 | Lumbar, Lymphoma Malignant Mixed | | 1 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | | 1 | Mediastinal, Lymphoma Malignant Mixed| X X | 2 | Pancreatic, Lymphoma Malignant Mixed | X | 2 | Renal, Lymphoma Malignant Lymphocytic| | 1 | Renal, Lymphoma Malignant Mixed | X X | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + A + + + + + + + + + M + + + + | 61 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + | 66 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X X X | 7 | __________________________________________________________________________|____________| Spleen | + + + + A + + + + + + + + + + + + + + | 67 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X X X | 6 | __________________________________________________________________________|____________| Thymus | + + + + A + + + + + + + + + + + + + M | 66 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X X X | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + M + + + M + + + M | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 4| 4| 4| 6| 2| 7| 7| 7| 7| 7| 1| 7| 2| 2| 7| 7| 6| 7| | | DAY ON TEST | 4| 5| 5| 5| 2| 8| 4| 4| 4| 4| 4| 4| 4| 8| 8| 4| 4| 9| 3| | | | 6| 6| 6| 6| 8| 0| 6| 6| 6| 6| 6| 5| 6| 1| 0| 6| 6| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 50 PPM | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + | 68 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + | 68 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + | 68 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + | 68 | Alveolar/Bronchiolar Adenoma | | 1 | Lymphoma Malignant Mixed | X | 1 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + | 68 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + | 68 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + A + + + + + + + + + + + + + + | 67 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 6 | __________________________________________________________________________|____________| Urinary Bladder | + + + + A + + + M + + + + + + + + A + | 59 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + | 68 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X X X X X | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 4| 2| 7| 7| 7| 4| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 1| 2| DAY ON TEST | 4| 1| 4| 4| 9| 5| 8| 4| 4| 4| 5| 0| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4| 8| 8| 8| | 3| 9| 3| 3| 7| 6| 0| 2| 3| 2| 5| 8| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 6| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + A + + + + + + + + + + + + + A + + + M + + + + +| __________________________________________________________________________| Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + A + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + A + + + + + + + + +| Hemangioma | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + + + + + A + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X X | Histiocytic Sarcoma | | Histiocytic Sarcoma, Metastatic, | | Uterus | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + M + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 4| 2| 7| 7| 7| 4| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 1| 2| DAY ON TEST | 4| 1| 4| 4| 9| 5| 8| 4| 4| 4| 5| 0| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4| 8| 8| 8| | 3| 9| 3| 3| 7| 6| 0| 2| 3| 2| 5| 8| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 6| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + M + M + + + + + + + + + + + + + + M + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + M + + + + + + + | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | | Histiocytic Sarcoma, Metastatic, | | Uterus | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Polyp Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node | + + + + | Axillary, Lymphoma Malignant | | Lymphocytic | X | Iliac, Lymphoma Malignant Lymphocytic| X | Inguinal, Lymphoma Malignant | | Lymphocytic | X | Lumbar, Histiocytic Sarcoma, | | Metastatic, Uterus | | Lumbar, Lymphoma Malignant | | Lymphocytic | X | Lumbar, Lymphoma Malignant Mixed | X | Lumbar, Sarcoma, Metastatic, Skin | | Mediastinal, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant Mixed| X | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 4| 2| 7| 7| 7| 4| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 1| 2| DAY ON TEST | 4| 1| 4| 4| 9| 5| 8| 4| 4| 4| 5| 0| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4| 8| 8| 8| | 3| 9| 3| 3| 7| 6| 0| 2| 3| 2| 5| 8| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 6| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Lymphoma Malignant Lymphocytic| X | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Histiocytic Sarcoma, Metastatic, | | Uterus | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +| Histiocytic Sarcoma | | Histiocytic Sarcoma, Metastatic, | | Uterus | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + M + + + + + + + + + + + + + + + + + +| Hemangioma | X | Hemangiosarcoma | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Histiocytic Sarcoma | | Histiocytic Sarcoma, Metastatic, | | Uterus | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + M + + + + + + + + + + + + + + + + M M| Adenocarcinoma | | Adenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 4| 2| 7| 7| 7| 4| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 1| 2| DAY ON TEST | 4| 1| 4| 4| 9| 5| 8| 4| 4| 4| 5| 0| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4| 8| 8| 8| | 3| 9| 3| 3| 7| 6| 0| 2| 3| 2| 5| 8| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 6| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Carcinoma, Metastatic, Thyroid Gland | X | Histiocytic Sarcoma, Metastatic, | | Uterus | | Lymphoma Malignant Lymphocytic | X | Sarcoma, Metastatic, Skin | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Uterus | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Harderian Gland | + + + | Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Urinary Bladder | + A + + + + + + + + + + + M + A + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 6| 7| 2| 5| 4| 7| 7| 6| 7| 2| 2| 7| 2| 7| 7| 4| 7| 4| 2| 4| 4| 7| 7| 7| DAY ON TEST | 4| 5| 4| 8| 7| 5| 4| 2| 0| 4| 8| 8| 4| 8| 4| 0| 5| 4| 5| 8| 5| 6| 4| 4| 4| | 2| 6| 2| 1| 8| 5| 3| 8| 7| 3| 0| 0| 3| 1| 3| 5| 5| 2| 5| 0| 6| 9| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + A + + M + + + A + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + A + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + A + + + + + + A + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + A + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + + A + + + + + + A + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + A + + + + + + A + + + + + + + + +| Hemangioma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + A + + + + + + A + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X| __________________________________________________________________________| Liver | + + + + + + + + A + + + + + + + + + + + + + + + +| Hemangiosarcoma | X| Hepatocellular Carcinoma | X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | | Histiocytic Sarcoma | X | Histiocytic Sarcoma, Metastatic, | | Uterus | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X| __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + A + + + + + + A + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + A + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Adrenal Medulla | + + + M + + + + A + + + + M + + + + + + + + + + +| Pheochromocytoma Malignant | | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 6| 7| 2| 5| 4| 7| 7| 6| 7| 2| 2| 7| 2| 7| 7| 4| 7| 4| 2| 4| 4| 7| 7| 7| DAY ON TEST | 4| 5| 4| 8| 7| 5| 4| 2| 0| 4| 8| 8| 4| 8| 4| 0| 5| 4| 5| 8| 5| 6| 4| 4| 4| | 2| 6| 2| 1| 8| 5| 3| 8| 7| 3| 0| 0| 3| 1| 3| 5| 5| 2| 5| 0| 6| 9| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + M M M M M + + M + + M + M + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + A + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +| Cystadenoma | | Histiocytic Sarcoma, Metastatic, | | Uterus | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Uterus | + + + + + + + + A + + + + + + + + + + + + + + + +| Hemangioma | X | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Polyp Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + A + + + + + + A + + M + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node | + + | Axillary, Lymphoma Malignant | | Lymphocytic | | Iliac, Lymphoma Malignant Lymphocytic| | Inguinal, Lymphoma Malignant | | Lymphocytic | | Lumbar, Histiocytic Sarcoma, | | Metastatic, Uterus | X | Lumbar, Lymphoma Malignant | | Lymphocytic | | Lumbar, Lymphoma Malignant Mixed | | Lumbar, Sarcoma, Metastatic, Skin | | Mediastinal, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant Mixed| | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 6| 7| 2| 5| 4| 7| 7| 6| 7| 2| 2| 7| 2| 7| 7| 4| 7| 4| 2| 4| 4| 7| 7| 7| DAY ON TEST | 4| 5| 4| 8| 7| 5| 4| 2| 0| 4| 8| 8| 4| 8| 4| 0| 5| 4| 5| 8| 5| 6| 4| 4| 4| | 2| 6| 2| 1| 8| 5| 3| 8| 7| 3| 0| 0| 3| 1| 3| 5| 5| 2| 5| 0| 6| 9| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Lymphoma Malignant Lymphocytic| | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + A + + + + + + + + + M + + + + + +| Histiocytic Sarcoma | X | Histiocytic Sarcoma, Metastatic, | | Uterus | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M A + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Histiocytic Sarcoma, Metastatic, | | Uterus | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X| __________________________________________________________________________| Spleen | + + + + + + + + M + + + + + + + + + + + + + + + +| Hemangioma | | Hemangiosarcoma | X | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X| __________________________________________________________________________| Thymus | + + + + + + + + M + + + + M + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Histiocytic Sarcoma | X | Histiocytic Sarcoma, Metastatic, | | Uterus | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + M + + + M + + + + + + + + + + + +| Adenocarcinoma | X | Adenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 6| 7| 2| 5| 4| 7| 7| 6| 7| 2| 2| 7| 2| 7| 7| 4| 7| 4| 2| 4| 4| 7| 7| 7| DAY ON TEST | 4| 5| 4| 8| 7| 5| 4| 2| 0| 4| 8| 8| 4| 8| 4| 0| 5| 4| 5| 8| 5| 6| 4| 4| 4| | 2| 6| 2| 1| 8| 5| 3| 8| 7| 3| 0| 0| 3| 1| 3| 5| 5| 2| 5| 0| 6| 9| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Carcinoma, Metastatic, Thyroid Gland | | Histiocytic Sarcoma, Metastatic, | | Uterus | X | Lymphoma Malignant Lymphocytic | | Sarcoma, Metastatic, Skin | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Uterus | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Harderian Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Urinary Bladder | + A + + + + + + A + + + + + + A + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X| _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | | DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | | | 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + M + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + | 63 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 67 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 65 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 65 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 65 | Hemangioma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 65 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 69 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X | 2 | Hepatocellular Adenoma | X X | 8 | Hepatocellular Adenoma, Multiple | X | 3 | Histiocytic Sarcoma | | 1 | Histiocytic Sarcoma, Metastatic, | | | Uterus | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 69 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 68 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + M + + + + + + + + + + | 69 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | | DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | | | 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 68 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 66 | Pheochromocytoma Malignant | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 | Adenoma | | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + M + + + M + + M + + M | 53 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + M + + + + | 68 | Pars Distalis, Adenoma | X X X X X X X | 15 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + M + + + + + + + + + + | 68 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + M + + + M + + + + + + | 44 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + | 69 | Cystadenoma | X | 1 | Histiocytic Sarcoma, Metastatic, | | | Uterus | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 69 | Hemangioma | | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Polyp Stromal | X X | 6 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 67 | Hemangiosarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node | + + | 8 | Axillary, Lymphoma Malignant | | | Lymphocytic | | 1 | Iliac, Lymphoma Malignant Lymphocytic| | 1 | Inguinal, Lymphoma Malignant | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | | DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | | | 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphocytic | | 1 | Lumbar, Histiocytic Sarcoma, | | | Metastatic, Uterus | | 1 | Lumbar, Lymphoma Malignant | | | Lymphocytic | | 1 | Lumbar, Lymphoma Malignant Mixed | | 1 | Lumbar, Sarcoma, Metastatic, Skin | X | 1 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | | 2 | Mediastinal, Lymphoma Malignant Mixed| | 1 | Renal, Lymphoma Malignant Lymphocytic| | 1 | Renal, Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 68 | Histiocytic Sarcoma | | 1 | Histiocytic Sarcoma, Metastatic, | | | Uterus | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 67 | Histiocytic Sarcoma | | 1 | Histiocytic Sarcoma, Metastatic, | | | Uterus | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 68 | Hemangioma | | 1 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X X | 4 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + + + + + + + + + | 67 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Histiocytic Sarcoma | | 1 | Histiocytic Sarcoma, Metastatic, | | | Uterus | | 1 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | | DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | | | 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + M + + + + + + + + + + + + M + + | 63 | Adenocarcinoma | | 1 | Adenoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma | | 1 | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + M + + + + + + + + + + | 69 | Alveolar/Bronchiolar Adenoma | | 4 | Alveolar/Bronchiolar Carcinoma | X | 2 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Histiocytic Sarcoma, Metastatic, | | | Uterus | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Sarcoma, Metastatic, Skin | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | Histiocytic Sarcoma, Metastatic, | | | Uterus | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + M + + + + + + + + + + | 69 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + + | 2 | __________________________________________________________________________|____________| Harderian Gland | + | 4 | Adenoma | X | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | | DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | | | 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 64 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | X X X | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 7| 7| 2| 4| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 2| 7| 7| 7| 2| 6| 7| DAY ON TEST | 4| 4| 4| 8| 5| 7| 5| 4| 4| 4| 4| 4| 4| 5| 4| 9| 4| 5| 8| 4| 4| 4| 8| 4| 4| | 1| 2| 2| 0| 6| 7| 5| 2| 2| 2| 2| 2| 1| 6| 1| 5| 1| 6| 1| 1| 1| 1| 1| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 500 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X X X X X X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | + + | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | X | Capsule, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + M + M + + + + + M + + M M + + + + + + + +| _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 7| 7| 2| 4| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 2| 7| 7| 7| 2| 6| 7| DAY ON TEST | 4| 4| 4| 8| 5| 7| 5| 4| 4| 4| 4| 4| 4| 5| 4| 9| 4| 5| 8| 4| 4| 4| 8| 4| 4| | 1| 2| 2| 0| 6| 7| 5| 2| 2| 2| 2| 2| 1| 6| 1| 5| 1| 6| 1| 1| 1| 1| 1| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 500 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + M| Pars Distalis, Adenoma | X X X X X | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +| Cystadenoma | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Polyp Stromal | | Endometrium, Adenocarcinoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node | + +| Lumbar, Lymphoma Malignant Mixed | X | Mediastinal, Lymphoma Malignant Mixed| X X| Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X X| __________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 7| 7| 2| 4| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 2| 7| 7| 7| 2| 6| 7| DAY ON TEST | 4| 4| 4| 8| 5| 7| 5| 4| 4| 4| 4| 4| 4| 5| 4| 9| 4| 5| 8| 4| 4| 4| 8| 4| 4| | 1| 2| 2| 0| 6| 7| 5| 2| 2| 2| 2| 2| 1| 6| 1| 5| 1| 6| 1| 1| 1| 1| 1| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 500 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + M + + M + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Sarcoma | X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | X | Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X | Carcinoma, Metastatic, Harderian | | Gland | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | Adenoma | | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 7| 7| 2| 4| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 2| 7| 7| 7| 2| 6| 7| DAY ON TEST | 4| 4| 4| 8| 5| 7| 5| 4| 4| 4| 4| 4| 4| 5| 4| 9| 4| 5| 8| 4| 4| 4| 8| 4| 4| | 1| 2| 2| 0| 6| 7| 5| 2| 2| 2| 2| 2| 1| 6| 1| 5| 1| 6| 1| 1| 1| 1| 1| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 500 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X X X| _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 4| 7| 2| 7| 7| 4| 7| 7| 6| 7| 2| 4| 7| 4| 7| 2| 4| 2| 7| 7| 7| 4| 7| 2| 7| DAY ON TEST | 5| 4| 8| 4| 4| 5| 4| 4| 9| 4| 8| 5| 4| 5| 4| 8| 5| 8| 4| 4| 4| 5| 4| 8| 4| | 5| 1| 1| 1| 2| 5| 1| 1| 0| 1| 0| 5| 1| 6| 1| 1| 6| 0| 1| 1| 1| 6| 1| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 500 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | X X X X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Mesentery | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | | Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + M + M + M M + M M M + M + + M + + + + + + + M| _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 4| 7| 2| 7| 7| 4| 7| 7| 6| 7| 2| 4| 7| 4| 7| 2| 4| 2| 7| 7| 7| 4| 7| 2| 7| DAY ON TEST | 5| 4| 8| 4| 4| 5| 4| 4| 9| 4| 8| 5| 4| 5| 4| 8| 5| 8| 4| 4| 4| 5| 4| 8| 4| | 5| 1| 1| 1| 2| 5| 1| 1| 0| 1| 0| 5| 1| 6| 1| 1| 6| 0| 1| 1| 1| 6| 1| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 500 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| Pars Distalis, Adenoma | X X | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + + +| __________________________________________________________________________| Ovary | + + I + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Polyp Stromal | X | Endometrium, Adenocarcinoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node | + + | Lumbar, Lymphoma Malignant Mixed | X X | Mediastinal, Lymphoma Malignant Mixed| X | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +| Carcinoma, Metastatic, Harderian | | Gland | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 4| 7| 2| 7| 7| 4| 7| 7| 6| 7| 2| 4| 7| 4| 7| 2| 4| 2| 7| 7| 7| 4| 7| 2| 7| DAY ON TEST | 5| 4| 8| 4| 4| 5| 4| 4| 9| 4| 8| 5| 4| 5| 4| 8| 5| 8| 4| 4| 4| 5| 4| 8| 4| | 5| 1| 1| 1| 2| 5| 1| 1| 0| 1| 0| 5| 1| 6| 1| 1| 6| 0| 1| 1| 1| 6| 1| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 500 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | | Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma | X | Carcinoma, Metastatic, Harderian | | Gland | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Adenoma | | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Uterus | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 4| 7| 2| 7| 7| 4| 7| 7| 6| 7| 2| 4| 7| 4| 7| 2| 4| 2| 7| 7| 7| 4| 7| 2| 7| DAY ON TEST | 5| 4| 8| 4| 4| 5| 4| 4| 9| 4| 8| 5| 4| 5| 4| 8| 5| 8| 4| 4| 4| 5| 4| 8| 4| | 5| 1| 1| 1| 2| 5| 1| 1| 0| 1| 0| 5| 1| 6| 1| 1| 6| 0| 1| 1| 1| 6| 1| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 500 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X X X | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| | | DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 8| 8| | | | 1| 0| 1| 1| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 9| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 500 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + M + + + + + + | 68 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Mixed | X X | 4 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 69 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Hepatocellular Carcinoma | X X X X | 5 | Hepatocellular Carcinoma, Multiple | | 1 | Hepatocellular Adenoma | X X X X | 14 | Hepatocellular Adenoma, Multiple | X X X X | 15 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X X | 5 | __________________________________________________________________________|____________| Mesentery | | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + M + + + + + + + + + + + | 69 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 | Adenocarcinoma, Metastatic, Uterus | | 1 | Capsule, Adenoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| | | DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 8| 8| | | | 1| 0| 1| 1| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 9| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 500 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 68 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | M M + M + + M + + + + + + + + + + + + + | 51 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 67 | Pars Distalis, Adenoma | X X | 9 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 69 | Follicular Cell, Adenoma | X | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M M + + + + + + + + + | 46 | __________________________________________________________________________|____________| Ovary | + + M + + + + + + + + + + + + + + + + + | 67 | Cystadenoma | | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 70 | Histiocytic Sarcoma | X | 1 | Polyp Stromal | | 1 | Endometrium, Adenocarcinoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 | Adenocarcinoma, Metastatic, Uterus | | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node | + | 5 | Lumbar, Lymphoma Malignant Mixed | X | 4 | Mediastinal, Lymphoma Malignant Mixed| X | 4 | Renal, Lymphoma Malignant Mixed | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + | 68 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 4 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M + + + + + + + + + + + M + + + + + + + | 67 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| | | DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 8| 8| | | | 1| 0| 1| 1| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 9| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 500 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant Mixed | X X X | 8 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | X X | 2 | Lymphoma Malignant Mixed | X X X X X | 9 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + | 69 | Adenocarcinoma, Metastatic, Uterus | | 1 | Lymphoma Malignant Lymphocytic | X X | 3 | Lymphoma Malignant Mixed | X X | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + M + + M M + + + + + + + + + + + | 64 | Adenocarcinoma, Metastatic, Uterus | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 70 | Histiocytic Sarcoma | | 1 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | Adenocarcinoma, Metastatic, Uterus | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Adenocarcinoma, Metastatic, Uterus | | 1 | Alveolar/Bronchiolar Adenoma | X X | 6 | Alveolar/Bronchiolar Carcinoma | | 2 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| | | DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 8| 8| | | | 1| 0| 1| 1| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 9| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 500 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 5 | Adenoma | X | 1 | Carcinoma | X | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Adenocarcinoma, Metastatic, Uterus | | 1 | Lymphoma Malignant Mixed | X X | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangioma | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant Lymphocytic | X X | 3 | Lymphoma Malignant Mixed | X X X X X X | 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 4| 6| 2| 7| 6| 4| 4| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 4| 5| 4| 5| 3| 7| 4| 7| 5| 5| 5| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 1| 1| 1| 4| 1| 5| 9| 4| 1| 9| 4| 5| 5| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + M + M + + + + + M + + + + M + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + M + + + + + + A + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X X X X X | Hepatocellular Adenoma, Multiple | X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Capsule, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + + M + + M + + + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 4| 6| 2| 7| 6| 4| 4| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 4| 5| 4| 5| 3| 7| 4| 7| 5| 5| 5| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 1| 1| 1| 4| 1| 5| 9| 4| 1| 9| 4| 5| 5| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + | Iliac, Lymphoma Malignant Mixed | | Inguinal, Lymphoma Malignant Mixed | | Lumbar, Lymphoma Malignant Mixed | | Mediastinal, Lymphoma Malignant Mixed| | Pancreatic, Lymphoma Malignant Mixed | | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + M + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + M + + + + + + I + + + + + + + M + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Harderian | | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 4| 6| 2| 7| 6| 4| 4| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 4| 5| 4| 5| 3| 7| 4| 7| 5| 5| 5| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 1| 1| 1| 4| 1| 5| 9| 4| 1| 9| 4| 5| 5| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Gland | | Hepatocellular Carcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 2| 7| 2| 7| 4| 2| 7| 7| 2| 4| 7| 4| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 4| DAY ON TEST | 7| 4| 7| 4| 5| 7| 4| 4| 7| 5| 4| 5| 4| 4| 4| 7| 4| 4| 4| 4| 7| 4| 4| 4| 5| | 5| 1| 5| 1| 5| 5| 1| 1| 5| 4| 1| 4| 1| 1| 1| 5| 1| 1| 1| 1| 4| 1| 1| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X | Hepatocellular Adenoma, Multiple | X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + M + I M M + M + + + + + + + + + + + + M + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 2| 7| 2| 7| 4| 2| 7| 7| 2| 4| 7| 4| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 4| DAY ON TEST | 7| 4| 7| 4| 5| 7| 4| 4| 7| 5| 4| 5| 4| 4| 4| 7| 4| 4| 4| 4| 7| 4| 4| 4| 5| | 5| 1| 5| 1| 5| 5| 1| 1| 5| 4| 1| 4| 1| 1| 1| 5| 1| 1| 1| 1| 4| 1| 1| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | Iliac, Lymphoma Malignant Mixed | | Inguinal, Lymphoma Malignant Mixed | | Lumbar, Lymphoma Malignant Mixed | | Mediastinal, Lymphoma Malignant Mixed| | Pancreatic, Lymphoma Malignant Mixed | | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + M + + + M +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Harderian | | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 2| 7| 2| 7| 4| 2| 7| 7| 2| 4| 7| 4| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 4| DAY ON TEST | 7| 4| 7| 4| 5| 7| 4| 4| 7| 5| 4| 5| 4| 4| 4| 7| 4| 4| 4| 4| 7| 4| 4| 4| 5| | 5| 1| 5| 1| 5| 5| 1| 1| 5| 4| 1| 4| 1| 1| 1| 5| 1| 1| 1| 1| 4| 1| 1| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Gland | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 7| 2| | | DAY ON TEST | 4| 5| 4| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 7| 4| 4| 4| 4| 7| | | | 1| 4| 1| 1| 1| 4| 1| 1| 1| 7| 1| 1| 1| 1| 5| 1| 0| 1| 1| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | M + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + A + + + | 64 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + | 67 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + | 69 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + | 68 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + | 67 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + | 68 | __________________________________________________________________________|____________| Intestine Small, Ileum | + M + + + + + + + + + + + + + + A + + + | 66 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma | X X X | 3 | Hepatocellular Carcinoma | X X X X | 8 | Hepatocellular Carcinoma, Multiple | | 2 | Hepatocellular Adenoma | X X X X | 15 | Hepatocellular Adenoma, Multiple | X | 5 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Mesentery | + | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 69 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + | 68 | __________________________________________________________________________|____________| Tongue | + + | 3 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + | 69 | Adenoma | | 1 | Capsule, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + M + + + + + + M + + + | 68 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | M M M + + + + + M + M + + + + + M M + + | 52 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 68 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 | Follicular Cell, Adenoma | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 7| 2| | | DAY ON TEST | 4| 5| 4| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 7| 4| 4| 4| 4| 7| | | | 1| 4| 1| 1| 1| 4| 1| 1| 1| 7| 1| 1| 1| 1| 5| 1| 0| 1| 1| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + | 54 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | | 17 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Lymph Node | + | 3 | Iliac, Lymphoma Malignant Mixed | X | 1 | Inguinal, Lymphoma Malignant Mixed | X | 1 | Lumbar, Lymphoma Malignant Mixed | X | 1 | Mediastinal, Lymphoma Malignant Mixed| X | 1 | Pancreatic, Lymphoma Malignant Mixed | X | 1 | Renal, Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + M + + + + + + + + + M | 66 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + | 68 | Lymphoma Malignant Mixed | X X | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 69 | Hemangiosarcoma | X | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Thymus | M + + + M + + M + + + M + + + M M + + + | 58 | Lymphoma Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 70 | Sarcoma | X X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 7| 2| | | DAY ON TEST | 4| 5| 4| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 7| 4| 4| 4| 4| 7| | | | 1| 4| 1| 1| 1| 4| 1| 1| 1| 7| 1| 1| 1| 1| 5| 1| 0| 1| 1| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Alveolar/Bronchiolar Adenoma | X X X X | 13 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | X X X X | 4 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 4 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + | 5 | Adenoma | X X | 4 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + A + + + | 68 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Mixed | X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 2| 6| 4| 7| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 2| 7| 7| DAY ON TEST | 5| 4| 4| 4| 7| 2| 5| 4| 0| 5| 7| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 5| 7| 4| 4| | 5| 0| 0| 0| 5| 8| 5| 0| 7| 5| 4| 0| 0| 0| 0| 4| 0| 0| 0| 0| 5| 5| 5| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 50 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + A + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + A + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + A + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + A + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + A + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | Sarcoma | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatoblastoma | | Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X | Hepatocellular Adenoma, Multiple | X X | Histiocytic Sarcoma | X | Lymphoma Malignant Mixed | | Sarcoma | | __________________________________________________________________________| Mesentery | + | Sarcoma | | __________________________________________________________________________| Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +| Sarcoma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +| Sarcoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Prostate | X | Hemangiosarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + M + + + A + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +| Adenoma | | _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 2| 6| 4| 7| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 2| 7| 7| DAY ON TEST | 5| 4| 4| 4| 7| 2| 5| 4| 0| 5| 7| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 5| 7| 4| 4| | 5| 0| 0| 0| 5| 8| 5| 0| 7| 5| 4| 0| 0| 0| 0| 4| 0| 0| 0| 0| 5| 5| 5| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 50 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Parathyroid Gland | M + + M M M + + + M M + M + + + + + + + I + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Sarcoma | | __________________________________________________________________________| Seminal Vesicle | + + + + + A + + + + + + + + + + + + + + + + + + +| Sarcoma | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | X | __________________________________________________________________________| Lymph Node | + + | Mediastinal, Histiocytic Sarcoma | X | Mediastinal, Lymphoma Malignant Mixed| X | Mediastinal, Sarcoma | | Pancreatic, Sarcoma | | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + + I + + + M + M + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + M + + A + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Mixed | X | Sarcoma | | __________________________________________________________________________| Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Mixed | X | Sarcoma | | __________________________________________________________________________| Thymus | + + + + + A + + + + M + + + + M + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Sarcoma | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 2| 6| 4| 7| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 2| 7| 7| DAY ON TEST | 5| 4| 4| 4| 7| 2| 5| 4| 0| 5| 7| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 5| 7| 4| 4| | 5| 0| 0| 0| 5| 8| 5| 0| 7| 5| 4| 0| 0| 0| 0| 4| 0| 0| 0| 0| 5| 5| 5| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 50 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + M + + + + + + + + +| Adenocarcinoma, Metastatic, Prostate | X | Alveolar/Bronchiolar Adenoma | X X X X | Alveolar/Bronchiolar Carcinoma | X X| Histiocytic Sarcoma | X | Sarcoma | | Sarcoma, Metastatic, Mesentery | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + A + + A + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 2| DAY ON TEST | 7| 7| 7| 7| 7| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 5| 4| 7| 7| | 4| 4| 4| 4| 4| 0| 0| 0| 5| 0| 0| 1| 1| 1| 1| 1| 1| 1| 0| 8| 0| 4| 0| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 50 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | Sarcoma | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatoblastoma | | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X X X X | Histiocytic Sarcoma | | Lymphoma Malignant Mixed | X | Sarcoma | | __________________________________________________________________________| Mesentery | | Sarcoma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Prostate | | Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 2| DAY ON TEST | 7| 7| 7| 7| 7| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 5| 4| 7| 7| | 4| 4| 4| 4| 4| 0| 0| 0| 5| 0| 0| 1| 1| 1| 1| 1| 1| 1| 0| 8| 0| 4| 0| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 50 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Parathyroid Gland | + M + + M + + + M + + + + + + + + + + + M + + M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + M + + + + + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + M +| Adenocarcinoma | | Sarcoma | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | | __________________________________________________________________________| Lymph Node | + | Mediastinal, Histiocytic Sarcoma | | Mediastinal, Lymphoma Malignant Mixed| | Mediastinal, Sarcoma | | Pancreatic, Sarcoma | | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + M + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | X X | Sarcoma | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | X | Sarcoma | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + M M + M + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Sarcoma | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 2| DAY ON TEST | 7| 7| 7| 7| 7| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 5| 4| 7| 7| | 4| 4| 4| 4| 4| 0| 0| 0| 5| 0| 0| 1| 1| 1| 1| 1| 1| 1| 0| 8| 0| 4| 0| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 50 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Prostate | | Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X X | Histiocytic Sarcoma | | Sarcoma | | Sarcoma, Metastatic, Mesentery | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Harderian Gland | + | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 4| 4| 4| 4| 4| 5| 5| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 1| 1| 1| 1| 1| 4| 5| 0| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + M + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 69 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 68 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 68 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 68 | Lymphoma Malignant Mixed | | 1 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma | | 2 | Hepatoblastoma | X | 1 | Hepatocellular Carcinoma | X X | 8 | Hepatocellular Carcinoma, Multiple | | 1 | Hepatocellular Adenoma | X X X X X | 8 | Hepatocellular Adenoma, Multiple | X X X X | 10 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Mixed | | 1 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Mesentery | + + | 3 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 69 | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | Adenocarcinoma, Metastatic, Prostate | | 1 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 4| 4| 4| 4| 4| 5| 5| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 1| 1| 1| 1| 1| 4| 5| 0| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 69 | Capsule, Adenoma | X | 2 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + M + + + + + + + + + + + + | 68 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M M + M M M + M + + + + + + + M M | 47 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 68 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 69 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + | 53 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + | 69 | Adenocarcinoma | | 1 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 69 | Sarcoma | X X | 2 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | + + | 5 | Mediastinal, Histiocytic Sarcoma | | 1 | Mediastinal, Lymphoma Malignant Mixed| | 1 | Mediastinal, Sarcoma | X X | 2 | Pancreatic, Sarcoma | X | 1 | Renal, Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + | 65 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + | 65 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Mixed | | 3 | Sarcoma | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 4| 4| 4| 4| 4| 5| 5| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 1| 1| 1| 1| 1| 4| 5| 0| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 69 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Mixed | | 2 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + M + + + M + + + M + + M + | 60 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 2 | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M + M M M M M M M M M M M M | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 69 | Adenocarcinoma, Metastatic, Prostate | | 1 | Alveolar/Bronchiolar Adenoma | X | 7 | Alveolar/Bronchiolar Carcinoma | X | 5 | Histiocytic Sarcoma | | 1 | Sarcoma | X | 1 | Sarcoma, Metastatic, Mesentery | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 2 | Adenoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 68 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 4| 4| 4| 4| 4| 5| 5| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 1| 1| 1| 1| 1| 4| 5| 0| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 2| 2| 2| 7| 7| 7| 2| 7| 4| 7| 7| 7| 7| 5| 2| 4| 2| 7| 7| 4| 7| 4| 4| 7| DAY ON TEST | 3| 7| 7| 7| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 8| 7| 5| 7| 3| 3| 5| 3| 5| 5| 3| | 7| 4| 5| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 5| 5| 5| 4| 6| 7| 4| 6| 4| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + M M + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Hemangiosarcoma | | Hepatoblastoma, Multiple | | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + M + + + M + + + + + M + + + M + M + M + + M| __________________________________________________________________________| Pituitary Gland | + + + + M + M + + + M + + M + + + + M + + + + + +| Pars Intermedia, Carcinoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 2| 2| 2| 7| 7| 7| 2| 7| 4| 7| 7| 7| 7| 5| 2| 4| 2| 7| 7| 4| 7| 4| 4| 7| DAY ON TEST | 3| 7| 7| 7| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 8| 7| 5| 7| 3| 3| 5| 3| 5| 5| 3| | 7| 4| 5| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 5| 5| 5| 4| 6| 7| 4| 6| 4| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | __________________________________________________________________________| Lymph Node | | Mediastinal, Lymphoma Malignant Mixed| | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + I + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + M + + + + + + + + + + + + +| Hemangiosarcoma | | __________________________________________________________________________| Thymus | + + + + + + + + M + + + M + + + + + + + + + + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + I + + + + + + + +| Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 2| 2| 2| 7| 7| 7| 2| 7| 4| 7| 7| 7| 7| 5| 2| 4| 2| 7| 7| 4| 7| 4| 4| 7| DAY ON TEST | 3| 7| 7| 7| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 8| 7| 5| 7| 3| 3| 5| 3| 5| 5| 3| | 7| 4| 5| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 5| 5| 5| 4| 6| 7| 4| 6| 4| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 2| 7| 7| 4| DAY ON TEST | 3| 4| 3| 3| 4| 4| 5| 3| 5| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 7| 4| 4| 5| | 6| 1| 6| 6| 0| 0| 4| 1| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 0| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 250 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | Hemangiosarcoma | X | Hepatoblastoma, Multiple | | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + M + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | M + + + + + M M M + + M + M + + + + + + M I M + +| __________________________________________________________________________| Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| Pars Intermedia, Carcinoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 2| 7| 7| 4| DAY ON TEST | 3| 4| 3| 3| 4| 4| 5| 3| 5| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 7| 4| 4| 5| | 6| 1| 6| 6| 0| 0| 4| 1| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 0| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 250 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | + | Mediastinal, Lymphoma Malignant Mixed| X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Thymus | + M M + + + + M + + M + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + M + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 69 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 2| 7| 7| 4| DAY ON TEST | 3| 4| 3| 3| 4| 4| 5| 3| 5| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 7| 4| 4| 5| | 6| 1| 6| 6| 0| 0| 4| 1| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 0| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 250 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 2| 7| 7| 6| 7| | | DAY ON TEST | 5| 4| 7| 4| 4| 4| 4| 4| 4| 4| 0| 7| 4| 2| 4| 7| 1| 4| 1| 4| | | | 4| 0| 5| 0| 0| 0| 0| 0| 0| 0| 1| 4| 0| 6| 0| 4| 0| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 250 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + M + + + + + + + + + | 69 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + A + + M + + + + M + | 64 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + A + + + + + A + + + | 68 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + A + + + | 68 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + A + + + | 68 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + A + + + | 68 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + A + + M | 67 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + A + + + | 67 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangioma | | 1 | Hemangiosarcoma | | 1 | Hepatoblastoma, Multiple | X | 1 | Hepatocellular Carcinoma | X X X X X X X X | 15 | Hepatocellular Carcinoma, Multiple | | 2 | Hepatocellular Adenoma | X X X | 12 | Hepatocellular Adenoma, Multiple | X X X | 6 | __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 | Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + + + M + M + + + M + M M | 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 64 | Pars Intermedia, Carcinoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + M + + + + + + + + + | 69 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 71 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 2| 7| 7| 6| 7| | | DAY ON TEST | 5| 4| 7| 4| 4| 4| 4| 4| 4| 4| 0| 7| 4| 2| 4| 7| 1| 4| 1| 4| | | | 4| 0| 5| 0| 0| 0| 0| 0| 0| 0| 1| 4| 0| 6| 0| 4| 0| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 250 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Penis | + | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + | 55 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + A + + + + M + + + + | 67 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 70 | Interstitial Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | | 1 | Mediastinal, Lymphoma Malignant Mixed| | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + | 67 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + M + M + | 65 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 69 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Thymus | + M + + M + + + M + + + + + + + + M M + | 58 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 69 | Lipoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Alveolar/Bronchiolar Adenoma | X | 5 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X X | 2 | Alveolar/Bronchiolar Carcinoma | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 72 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 2| 7| 7| 6| 7| | | DAY ON TEST | 5| 4| 7| 4| 4| 4| 4| 4| 4| 4| 0| 7| 4| 2| 4| 7| 1| 4| 1| 4| | | | 4| 0| 5| 0| 0| 0| 0| 0| 0| 0| 1| 4| 0| 6| 0| 4| 0| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 250 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 4 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + M + + + + + + + + + | 68 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + A + + + + + A + + + | 68 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Mixed | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 73 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 5| 7| 2| 7| 7| 7| 6| 7| 4| 6| 2| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 4| 7| 4| 7| DAY ON TEST | 7| 3| 7| 3| 3| 3| 8| 3| 5| 5| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 5| 3| | 4| 0| 5| 0| 3| 0| 7| 6| 5| 4| 4| 4| 6| 6| 3| 3| 3| 3| 3| 5| 3| 4| 3| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | A + + + + + A + + A M + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + A + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X X X| __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + + A + M + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatoblastoma | | Hepatoblastoma, Multiple | X | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X X X X X X| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Mesentery | | Hepatoblastoma, Metastatic, Liver | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | A + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M M + M + + + + + + + M + M +| __________________________________________________________________________| Pituitary Gland | I + + + + + + M + + + + + + + M + + + + + + + + +| Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 74 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 5| 7| 2| 7| 7| 7| 6| 7| 4| 6| 2| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 4| 7| 4| 7| DAY ON TEST | 7| 3| 7| 3| 3| 3| 8| 3| 5| 5| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 5| 3| | 4| 0| 5| 0| 3| 0| 7| 6| 5| 4| 4| 4| 6| 6| 3| 3| 3| 3| 3| 5| 3| 4| 3| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Mast Cell Tumor NOS | X | __________________________________________________________________________| Lymph Node | + + | Lumbar, Lymphoma Malignant Mixed | X | Renal, Lymphoma Malignant Lymphocytic| X | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | Mast Cell Tumor NOS | X | __________________________________________________________________________| Thymus | + I + + + + M + + + + M + M I + M + M + M M + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | | Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 75 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 5| 7| 2| 7| 7| 7| 6| 7| 4| 6| 2| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 4| 7| 4| 7| DAY ON TEST | 7| 3| 7| 3| 3| 3| 8| 3| 5| 5| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 5| 3| | 4| 0| 5| 0| 3| 0| 7| 6| 5| 4| 4| 4| 6| 6| 3| 3| 3| 3| 3| 5| 3| 4| 3| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Harderian | | Gland | X | Hepatoblastoma, Metastatic, Liver | X | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Adenoma | | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X X X X X| _____________________________________________________________________________________________________________________| Page 76 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 2| 2| 7| 7| 7| 6| 7| 7| 4| 7| 2| 7| 2| 7| 2| 4| 7| 4| 4| 7| 7| 2| 7| 7| 7| DAY ON TEST | 7| 7| 3| 3| 3| 1| 3| 3| 5| 3| 7| 3| 7| 3| 7| 5| 3| 5| 5| 3| 3| 7| 3| 3| 3| | 5| 5| 3| 6| 6| 8| 5| 5| 4| 6| 5| 6| 4| 5| 5| 4| 5| 5| 5| 3| 3| 5| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatoblastoma | X X | Hepatoblastoma, Multiple | | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X X X X | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Mesentery | + | Hepatoblastoma, Metastatic, Liver | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | I + + + + + + + + + + + + + + + + + + + + I + + M| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + M M + M + M + + + M + M M M M + M + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + M + M + + + + + + + + M + + + + + + + +| Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 2| 2| 7| 7| 7| 6| 7| 7| 4| 7| 2| 7| 2| 7| 2| 4| 7| 4| 4| 7| 7| 2| 7| 7| 7| DAY ON TEST | 7| 7| 3| 3| 3| 1| 3| 3| 5| 3| 7| 3| 7| 3| 7| 5| 3| 5| 5| 3| 3| 7| 3| 3| 3| | 5| 5| 3| 6| 6| 8| 5| 5| 4| 6| 5| 6| 4| 5| 5| 4| 5| 5| 5| 3| 3| 5| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + M M + + M + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X| Mast Cell Tumor NOS | | __________________________________________________________________________| Lymph Node | | Lumbar, Lymphoma Malignant Mixed | | Renal, Lymphoma Malignant Lymphocytic| | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + M + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + M + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Mast Cell Tumor NOS | | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | | Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 _____________________________________________________________________________________________________________________ | 2| 2| 7| 7| 7| 6| 7| 7| 4| 7| 2| 7| 2| 7| 2| 4| 7| 4| 4| 7| 7| 2| 7| 7| 7| DAY ON TEST | 7| 7| 3| 3| 3| 1| 3| 3| 5| 3| 7| 3| 7| 3| 7| 5| 3| 5| 5| 3| 3| 7| 3| 3| 3| | 5| 5| 3| 6| 6| 8| 5| 5| 4| 6| 5| 6| 4| 5| 5| 4| 5| 5| 5| 3| 3| 5| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Harderian | | Gland | | Hepatoblastoma, Metastatic, Liver | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | Adenoma | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 6| 7| 2| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | | DAY ON TEST | 8| 3| 7| 3| 5| 3| 5| 3| 3| 4| 3| 3| 0| 3| 2| 3| 3| 3| 0| 3| | | | 4| 6| 5| 3| 5| 3| 4| 3| 4| 7| 4| 4| 0| 3| 6| 4| 4| 3| 7| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + A + | 62 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + | 67 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + A + | 67 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + | 67 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + | 68 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + | 66 | Lymphoma Malignant Mixed | | 5 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + | 65 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Hepatoblastoma | X X | 4 | Hepatoblastoma, Multiple | | 1 | Hepatocellular Carcinoma | X X X X | 11 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X X X X X X | 16 | Hepatocellular Adenoma, Multiple | X X X X X | 15 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Mesentery | + | 2 | Hepatoblastoma, Metastatic, Liver | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma, Metastatic, Spleen | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Tongue | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + | 66 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 80 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 6| 7| 2| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | | DAY ON TEST | 8| 3| 7| 3| 5| 3| 5| 3| 3| 4| 3| 3| 0| 3| 2| 3| 3| 3| 0| 3| | | | 4| 6| 5| 3| 5| 3| 4| 3| 4| 7| 4| 4| 0| 3| 6| 4| 4| 3| 7| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + M + + M M + + + M + + + | 49 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 64 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + M + | 54 | __________________________________________________________________________|____________| Prostate | + + + + + + M + + + + + + + + + + + + + | 65 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | | 7 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 69 | Hemangiosarcoma | | 2 | Mast Cell Tumor NOS | | 1 | __________________________________________________________________________|____________| Lymph Node | | 2 | Lumbar, Lymphoma Malignant Mixed | | 1 | Renal, Lymphoma Malignant Lymphocytic| | 1 | Renal, Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + A + | 66 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + A + | 65 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 7 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 70 | Hemangiosarcoma | X | 3 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 2 | Mast Cell Tumor NOS | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + M + M + + + M + | 56 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 81 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 6| 7| 2| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | | DAY ON TEST | 8| 3| 7| 3| 5| 3| 5| 3| 3| 4| 3| 3| 0| 3| 2| 3| 3| 3| 0| 3| | | | 4| 6| 5| 3| 5| 3| 4| 3| 4| 7| 4| 4| 0| 3| 6| 4| 4| 3| 7| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M + M M M + M M M M M M | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 70 | Fibroma | X | 1 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Alveolar/Bronchiolar Adenoma | X X | 5 | Alveolar/Bronchiolar Carcinoma | X | 1 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Hepatoblastoma, Metastatic, Liver | | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 2 | Adenoma | X | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + A + | 67 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 82 NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97 Route: DOSED FEED Time: 16:31:36 __________________________________________________________________________________________________________________________________ | 6| 7| 2| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | | DAY ON TEST | 8| 3| 7| 3| 5| 3| 5| 3| 3| 4| 3| 3| 0| 3| 2| 3| 3| 3| 0| 3| | | | 4| 6| 5| 3| 5| 3| 4| 3| 4| 7| 4| 4| 0| 3| 6| 4| 4| 3| 7| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 83 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------