TDMS Study 05150-02 Pathology Tables
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
Facility: TSI Mason Research
Chemical CAS #: 298-59-9
Lock Date: 02/19/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 4| 4| 7| 2| 0| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 4| 7| 4| 2| 7| 7| 2| 4| 7|
DAY ON TEST | 5| 5| 4| 8| 6| 2| 4| 4| 4| 4| 5| 5| 4| 4| 7| 4| 5| 4| 5| 8| 4| 4| 8| 5| 4|
| 6| 5| 7| 1| 7| 8| 6| 7| 7| 7| 5| 5| 7| 6| 3| 7| 5| 7| 6| 0| 7| 7| 0| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + A + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + M + + + + + + + + + + + + + +|
Polyp Adenomatous | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + A + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + A + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | +|
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Medulla | M + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | M M + M M + + M + + M M M M + + M + + M + + M + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 4| 4| 7| 2| 0| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 4| 7| 4| 2| 7| 7| 2| 4| 7|
DAY ON TEST | 5| 5| 4| 8| 6| 2| 4| 4| 4| 4| 5| 5| 4| 4| 7| 4| 5| 4| 5| 8| 4| 4| 8| 5| 4|
| 6| 5| 7| 1| 7| 8| 6| 7| 7| 7| 5| 5| 7| 6| 3| 7| 5| 7| 6| 0| 7| 7| 0| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + I + + + + + + + +|
Pars Distalis, Adenoma | X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemangiosarcoma | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + M +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + M + + + + M + + + + + +|
Cystadenoma | X |
Teratoma NOS | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Histiocytic Sarcoma | X |
Leiomyoma | X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Iliac, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + M M + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + M + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 4| 4| 7| 2| 0| 6| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 4| 7| 4| 2| 7| 7| 2| 4| 7|
DAY ON TEST | 5| 5| 4| 8| 6| 2| 4| 4| 4| 4| 5| 5| 4| 4| 7| 4| 5| 4| 5| 8| 4| 4| 8| 5| 4|
| 6| 5| 7| 1| 7| 8| 6| 7| 7| 7| 5| 5| 7| 6| 3| 7| 5| 7| 6| 0| 7| 7| 0| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + M + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 2| 7| 7| 5| 7| 3| 2| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 8| 4| 4| 7| 4| 4| 8| 4| 4| 4| 8| 4| 8| 0| 4| 0| 4| 4| 0| 2| 4| 8| 4| 4| 4|
| 1| 7| 7| 1| 7| 8| 0| 7| 7| 7| 1| 7| 0| 8| 7| 8| 7| 7| 8| 1| 7| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + M + + + + + + + + + + + + A + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + A + + +|
Polyp Adenomatous | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + M + M M I + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 2| 7| 7| 5| 7| 3| 2| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 8| 4| 4| 7| 4| 4| 8| 4| 4| 4| 8| 4| 8| 0| 4| 0| 4| 4| 0| 2| 4| 8| 4| 4| 4|
| 1| 7| 7| 1| 7| 8| 0| 7| 7| 7| 1| 7| 0| 8| 7| 8| 7| 7| 8| 1| 7| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Adenoma | X X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemangiosarcoma | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + M M + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + M M + + + + + +|
Cystadenoma | X |
Teratoma NOS | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Histiocytic Sarcoma | X |
Leiomyoma | |
Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant Mixed| X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + I + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + M + + + + M + + +|
Lymphoma Malignant Mixed | X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Mixed | X X X X|
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 2| 7| 7| 5| 7| 3| 2| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 8| 4| 4| 7| 4| 4| 8| 4| 4| 4| 8| 4| 8| 0| 4| 0| 4| 4| 0| 2| 4| 8| 4| 4| 4|
| 1| 7| 7| 1| 7| 8| 0| 7| 7| 7| 1| 7| 0| 8| 7| 8| 7| 7| 8| 1| 7| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + M A + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 2| 4| 2| 2| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 4| 5| 4| 8| 5| 8| 8| 4| 4| 8| 8| 4| 4| 4| 4| 4| 4| 4| | |
| 6| 7| 6| 7| 0| 5| 1| 1| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + | 64 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + | 67 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + | 65 |
Polyp Adenomatous | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + | 65 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + | 65 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + | 69 |
Hemangioma | | 1 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | | 3 |
Hepatocellular Carcinoma, Multiple | X | 2 |
Hepatocellular Adenoma | X X | 5 |
Hepatocellular Adenoma, Multiple | X X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 5 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + | 68 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + M + + + + + + + | 67 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Tongue | | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + | 69 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 2| 4| 2| 2| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 4| 5| 4| 8| 5| 8| 8| 4| 4| 8| 8| 4| 4| 4| 4| 4| 4| 4| | |
| 6| 7| 6| 7| 0| 5| 1| 1| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + | 68 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M M M M + + M M + + + + + + + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + | 67 |
Pars Distalis, Adenoma | X X | 7 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + | 43 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + | 65 |
Cystadenoma | | 2 |
Teratoma NOS | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + | 69 |
Hemangioma | X | 1 |
Histiocytic Sarcoma | | 2 |
Leiomyoma | | 1 |
Polyp Stromal | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Iliac, Lymphoma Malignant Mixed | | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 2 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + | 67 |
Lymphoma Malignant Mixed | X X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + | 65 |
Lymphoma Malignant Mixed | X X X | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 2| 4| 2| 2| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 4| 5| 4| 8| 5| 8| 8| 4| 4| 8| 8| 4| 4| 4| 4| 4| 4| 4| | |
| 6| 7| 6| 7| 0| 5| 1| 1| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemangiosarcoma | | 2 |
Lymphoma Malignant Mixed | X X X X | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + | 65 |
Lymphoma Malignant Mixed | X X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + M + M + + + + M + M + + + | 59 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + | 69 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + | 68 |
Alveolar/Bronchiolar Adenoma | | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + | 69 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + | 63 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + | 69 |
Histiocytic Sarcoma | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 2| 4| 2| 2| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 4| 5| 4| 8| 5| 8| 8| 4| 4| 8| 8| 4| 4| 4| 4| 4| 4| 4| | |
| 6| 7| 6| 7| 0| 5| 1| 1| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X X | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 2| 7| 7| 4| 4| 2| 7| 7| 7| 7| 2| 7| 0| 6| 2| 7| 7| 7| 4| 4| 4|
DAY ON TEST | 9| 5| 4| 4| 8| 4| 4| 5| 5| 8| 4| 4| 4| 4| 8| 4| 1| 8| 8| 4| 4| 4| 6| 5| 5|
| 9| 6| 3| 3| 1| 3| 3| 5| 5| 1| 3| 3| 3| 1| 0| 3| 2| 1| 1| 3| 3| 6| 2| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + M + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X X|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + I + + + + + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + M M M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + M + + + + + + + |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X X |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 2| 7| 7| 4| 4| 2| 7| 7| 7| 7| 2| 7| 0| 6| 2| 7| 7| 7| 4| 4| 4|
DAY ON TEST | 9| 5| 4| 4| 8| 4| 4| 5| 5| 8| 4| 4| 4| 4| 8| 4| 1| 8| 8| 4| 4| 4| 6| 5| 5|
| 9| 6| 3| 3| 1| 3| 3| 5| 5| 1| 3| 3| 3| 1| 0| 3| 2| 1| 1| 3| 3| 6| 2| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cystadenoma, Multiple | X |
Lymphoma Malignant Lymphocytic | |
Teratoma NOS | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + M + + + + M + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 2| 7| 7| 4| 4| 2| 7| 7| 7| 7| 2| 7| 0| 6| 2| 7| 7| 7| 4| 4| 4|
DAY ON TEST | 9| 5| 4| 4| 8| 4| 4| 5| 5| 8| 4| 4| 4| 4| 8| 4| 1| 8| 8| 4| 4| 4| 6| 5| 5|
| 9| 6| 3| 3| 1| 3| 3| 5| 5| 1| 3| 3| 3| 1| 0| 3| 2| 1| 1| 3| 3| 6| 2| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 6| 4| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 2| 7| 3| 4| 6| 1| 7|
DAY ON TEST | 4| 8| 4| 4| 4| 2| 5| 8| 4| 4| 4| 4| 4| 4| 0| 4| 4| 0| 8| 4| 9| 5| 9| 5| 4|
| 6| 1| 6| 6| 3| 5| 5| 8| 3| 6| 6| 6| 6| 6| 3| 6| 6| 3| 1| 6| 1| 5| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + A + + + + + + A + + A + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + A + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + A + + A + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + A + + + + + A +|
Adenocarcinoma | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + A + + + + + + A + + A + + + + + A +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + + + + + + + + M + M + + M + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 6| 4| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 2| 7| 3| 4| 6| 1| 7|
DAY ON TEST | 4| 8| 4| 4| 4| 2| 5| 8| 4| 4| 4| 4| 4| 4| 0| 4| 4| 0| 8| 4| 9| 5| 9| 5| 4|
| 6| 1| 6| 6| 3| 5| 5| 8| 3| 6| 6| 6| 6| 6| 3| 6| 6| 3| 1| 6| 1| 5| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cystadenoma, Multiple | |
Lymphoma Malignant Lymphocytic | X |
Teratoma NOS | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + M + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + A +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + M + + + M + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 6| 4| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 2| 7| 3| 4| 6| 1| 7|
DAY ON TEST | 4| 8| 4| 4| 4| 2| 5| 8| 4| 4| 4| 4| 4| 4| 0| 4| 4| 0| 8| 4| 9| 5| 9| 5| 4|
| 6| 1| 6| 6| 3| 5| 5| 8| 3| 6| 6| 6| 6| 6| 3| 6| 6| 3| 1| 6| 1| 5| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + A + + + + + + A + + A + + + + + A +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 6| 2| 7| 7| 7| 7| 7| 1| 7| 2| 2| 7| 7| 6| 7| | |
DAY ON TEST | 4| 5| 5| 5| 2| 8| 4| 4| 4| 4| 4| 4| 4| 8| 8| 4| 4| 9| 3| | |
| 6| 6| 6| 6| 8| 0| 6| 6| 6| 6| 6| 5| 6| 1| 0| 6| 6| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50 PPM | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Gallbladder | + M M + A + + + + + + + + + + + + A + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + A + | 63 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + A + | 62 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + A + | 63 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + A + | 61 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + A + + + + + + + + + + + + + + | 67 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X X | 3 |
Hepatocellular Adenoma | X X X | 11 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + | 67 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | 68 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + A + | 65 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + A + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + A + + + + + + + + + + + + + + | 64 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + | 67 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M M M + + M M M M + + + + M M + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + M + + + + + + + + + + | 66 |
Pars Distalis, Adenoma | X X | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + | 66 |
Follicular Cell, Adenoma | X X X X | 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 6| 2| 7| 7| 7| 7| 7| 1| 7| 2| 2| 7| 7| 6| 7| | |
DAY ON TEST | 4| 5| 5| 5| 2| 8| 4| 4| 4| 4| 4| 4| 4| 8| 8| 4| 4| 9| 3| | |
| 6| 6| 6| 6| 8| 0| 6| 6| 6| 6| 6| 5| 6| 1| 0| 6| 6| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50 PPM | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + | 41 |
__________________________________________________________________________|____________|
Ovary | + + + + A + + + + + + + + + + + + + + | 67 |
Cystadenoma | | 4 |
Cystadenoma, Multiple | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Teratoma NOS | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + | 68 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| X X | 2 |
Pancreatic, Lymphoma Malignant Mixed | X | 2 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + A + + + + + + + + + M + + + + | 61 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + | 66 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + A + + + + + + + + + + + + + + | 67 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X | 6 |
__________________________________________________________________________|____________|
Thymus | + + + + A + + + + + + + + + + + + + M | 66 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + + + M + + + M | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 6| 2| 7| 7| 7| 7| 7| 1| 7| 2| 2| 7| 7| 6| 7| | |
DAY ON TEST | 4| 5| 5| 5| 2| 8| 4| 4| 4| 4| 4| 4| 4| 8| 8| 4| 4| 9| 3| | |
| 6| 6| 6| 6| 8| 0| 6| 6| 6| 6| 6| 5| 6| 1| 0| 6| 6| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50 PPM | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + | 68 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + | 68 |
Alveolar/Bronchiolar Adenoma | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + | 68 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + A + + + + + + + + + + + + + + | 67 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + M + + + + + + + + A + | 59 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + | 68 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X X X | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 2| 7| 7| 7| 4| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 1| 2|
DAY ON TEST | 4| 1| 4| 4| 9| 5| 8| 4| 4| 4| 5| 0| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4| 8| 8| 8|
| 3| 9| 3| 3| 7| 6| 0| 2| 3| 2| 5| 8| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + + A + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + A + + + + + + + + +|
Hemangioma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + M + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 2| 7| 7| 7| 4| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 1| 2|
DAY ON TEST | 4| 1| 4| 4| 9| 5| 8| 4| 4| 4| 5| 0| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4| 8| 8| 8|
| 3| 9| 3| 3| 7| 6| 0| 2| 3| 2| 5| 8| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M + + + + + + + + + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + |
Axillary, Lymphoma Malignant | |
Lymphocytic | X |
Iliac, Lymphoma Malignant Lymphocytic| X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Histiocytic Sarcoma, | |
Metastatic, Uterus | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant Mixed | X |
Lumbar, Sarcoma, Metastatic, Skin | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 2| 7| 7| 7| 4| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 1| 2|
DAY ON TEST | 4| 1| 4| 4| 9| 5| 8| 4| 4| 4| 5| 0| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4| 8| 8| 8|
| 3| 9| 3| 3| 7| 6| 0| 2| 3| 2| 5| 8| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
Histiocytic Sarcoma | |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Histiocytic Sarcoma | |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + + + + + + + + M M|
Adenocarcinoma | |
Adenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 2| 7| 7| 7| 4| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 1| 2|
DAY ON TEST | 4| 1| 4| 4| 9| 5| 8| 4| 4| 4| 5| 0| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4| 8| 8| 8|
| 3| 9| 3| 3| 7| 6| 0| 2| 3| 2| 5| 8| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Carcinoma, Metastatic, Thyroid Gland | X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant Lymphocytic | X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + M + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 2| 5| 4| 7| 7| 6| 7| 2| 2| 7| 2| 7| 7| 4| 7| 4| 2| 4| 4| 7| 7| 7|
DAY ON TEST | 4| 5| 4| 8| 7| 5| 4| 2| 0| 4| 8| 8| 4| 8| 4| 0| 5| 4| 5| 8| 5| 6| 4| 4| 4|
| 2| 6| 2| 1| 8| 5| 3| 8| 7| 3| 0| 0| 3| 1| 3| 5| 5| 2| 5| 0| 6| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + M + + + A + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + A + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + A + + + + + + A + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + A + + + + + + A + + + + + + + + +|
Hemangioma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + A + + + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Liver | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + A + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
__________________________________________________________________________|
Adrenal Medulla | + + + M + + + + A + + + + M + + + + + + + + + + +|
Pheochromocytoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 2| 5| 4| 7| 7| 6| 7| 2| 2| 7| 2| 7| 7| 4| 7| 4| 2| 4| 4| 7| 7| 7|
DAY ON TEST | 4| 5| 4| 8| 7| 5| 4| 2| 0| 4| 8| 8| 4| 8| 4| 0| 5| 4| 5| 8| 5| 6| 4| 4| 4|
| 2| 6| 2| 1| 8| 5| 3| 8| 7| 3| 0| 0| 3| 1| 3| 5| 5| 2| 5| 0| 6| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + M M M M M + + M + + M + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cystadenoma | |
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Uterus | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hemangioma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + A + + + + + + A + + M + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + |
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Iliac, Lymphoma Malignant Lymphocytic| |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Histiocytic Sarcoma, | |
Metastatic, Uterus | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant Mixed | |
Lumbar, Sarcoma, Metastatic, Skin | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 2| 5| 4| 7| 7| 6| 7| 2| 2| 7| 2| 7| 7| 4| 7| 4| 2| 4| 4| 7| 7| 7|
DAY ON TEST | 4| 5| 4| 8| 7| 5| 4| 2| 0| 4| 8| 8| 4| 8| 4| 0| 5| 4| 5| 8| 5| 6| 4| 4| 4|
| 2| 6| 2| 1| 8| 5| 3| 8| 7| 3| 0| 0| 3| 1| 3| 5| 5| 2| 5| 0| 6| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + A + + + + + + + + + M + + + + + +|
Histiocytic Sarcoma | X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M A + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Spleen | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + M + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Histiocytic Sarcoma | X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + M + + + + + + + + + + + +|
Adenocarcinoma | X |
Adenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 2| 5| 4| 7| 7| 6| 7| 2| 2| 7| 2| 7| 7| 4| 7| 4| 2| 4| 4| 7| 7| 7|
DAY ON TEST | 4| 5| 4| 8| 7| 5| 4| 2| 0| 4| 8| 8| 4| 8| 4| 0| 5| 4| 5| 8| 5| 6| 4| 4| 4|
| 2| 6| 2| 1| 8| 5| 3| 8| 7| 3| 0| 0| 3| 1| 3| 5| 5| 2| 5| 0| 6| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Carcinoma, Metastatic, Thyroid Gland | |
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant Lymphocytic | |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Uterus | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + A + + + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | |
DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | |
| 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + M + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + | 63 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 67 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 65 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 65 |
Hemangioma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 65 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 69 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Adenoma | X X | 8 |
Hepatocellular Adenoma, Multiple | X | 3 |
Histiocytic Sarcoma | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 69 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + M + + + + + + + + + + | 69 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | |
DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | |
| 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 68 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 66 |
Pheochromocytoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + M + + + M + + M + + M | 53 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + | 68 |
Pars Distalis, Adenoma | X X X X X X X | 15 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + | 68 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + M + + + + + + | 44 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 69 |
Cystadenoma | X | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 69 |
Hemangioma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Polyp Stromal | X X | 6 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 67 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + | 8 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Iliac, Lymphoma Malignant Lymphocytic| | 1 |
Inguinal, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | |
DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | |
| 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphocytic | | 1 |
Lumbar, Histiocytic Sarcoma, | | |
Metastatic, Uterus | | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Lumbar, Sarcoma, Metastatic, Skin | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 68 |
Histiocytic Sarcoma | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 67 |
Histiocytic Sarcoma | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 68 |
Hemangioma | | 1 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + | 67 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | |
DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | |
| 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + + + + + + + + M + + | 63 |
Adenocarcinoma | | 1 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangiosarcoma | | 1 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + M + + + + + + + + + + | 69 |
Alveolar/Bronchiolar Adenoma | | 4 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + M + + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 2| 7| 7| 2| 7| 7| | |
DAY ON TEST | 5| 4| 8| 4| 4| 4| 5| 5| 4| 5| 4| 4| 4| 4| 8| 4| 4| 8| 4| 4| | |
| 5| 2| 1| 2| 2| 2| 5| 6| 3| 6| 3| 2| 2| 2| 1| 3| 3| 0| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 64 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 4| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 2| 7| 7| 7| 2| 6| 7|
DAY ON TEST | 4| 4| 4| 8| 5| 7| 5| 4| 4| 4| 4| 4| 4| 5| 4| 9| 4| 5| 8| 4| 4| 4| 8| 4| 4|
| 1| 2| 2| 0| 6| 7| 5| 2| 2| 2| 2| 2| 1| 6| 1| 5| 1| 6| 1| 1| 1| 1| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X |
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + + + + + M + + M M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 4| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 2| 7| 7| 7| 2| 6| 7|
DAY ON TEST | 4| 4| 4| 8| 5| 7| 5| 4| 4| 4| 4| 4| 4| 5| 4| 9| 4| 5| 8| 4| 4| 4| 8| 4| 4|
| 1| 2| 2| 0| 6| 7| 5| 2| 2| 2| 2| 2| 1| 6| 1| 5| 1| 6| 1| 1| 1| 1| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Adenoma | X X X X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cystadenoma | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Polyp Stromal | |
Endometrium, Adenocarcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + +|
Lumbar, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant Mixed| X X|
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
Gland | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X|
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 4| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 2| 7| 7| 7| 2| 6| 7|
DAY ON TEST | 4| 4| 4| 8| 5| 7| 5| 4| 4| 4| 4| 4| 4| 5| 4| 9| 4| 5| 8| 4| 4| 4| 8| 4| 4|
| 1| 2| 2| 0| 6| 7| 5| 2| 2| 2| 2| 2| 1| 6| 1| 5| 1| 6| 1| 1| 1| 1| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + M + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Sarcoma | X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Harderian | |
Gland | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
Gland | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 4| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 2| 7| 7| 7| 2| 6| 7|
DAY ON TEST | 4| 4| 4| 8| 5| 7| 5| 4| 4| 4| 4| 4| 4| 5| 4| 9| 4| 5| 8| 4| 4| 4| 8| 4| 4|
| 1| 2| 2| 0| 6| 7| 5| 2| 2| 2| 2| 2| 1| 6| 1| 5| 1| 6| 1| 1| 1| 1| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 4| 7| 7| 6| 7| 2| 4| 7| 4| 7| 2| 4| 2| 7| 7| 7| 4| 7| 2| 7|
DAY ON TEST | 5| 4| 8| 4| 4| 5| 4| 4| 9| 4| 8| 5| 4| 5| 4| 8| 5| 8| 4| 4| 4| 5| 4| 8| 4|
| 5| 1| 1| 1| 2| 5| 1| 1| 0| 1| 0| 5| 1| 6| 1| 1| 6| 0| 1| 1| 1| 6| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | |
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + M M + M M M + M + + M + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 4| 7| 7| 6| 7| 2| 4| 7| 4| 7| 2| 4| 2| 7| 7| 7| 4| 7| 2| 7|
DAY ON TEST | 5| 4| 8| 4| 4| 5| 4| 4| 9| 4| 8| 5| 4| 5| 4| 8| 5| 8| 4| 4| 4| 5| 4| 8| 4|
| 5| 1| 1| 1| 2| 5| 1| 1| 0| 1| 0| 5| 1| 6| 1| 1| 6| 0| 1| 1| 1| 6| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Adenoma | X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + +|
__________________________________________________________________________|
Ovary | + + I + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Polyp Stromal | X |
Endometrium, Adenocarcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Lymphoma Malignant Mixed | X X |
Mediastinal, Lymphoma Malignant Mixed| X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Carcinoma, Metastatic, Harderian | |
Gland | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 4| 7| 7| 6| 7| 2| 4| 7| 4| 7| 2| 4| 2| 7| 7| 7| 4| 7| 2| 7|
DAY ON TEST | 5| 4| 8| 4| 4| 5| 4| 4| 9| 4| 8| 5| 4| 5| 4| 8| 5| 8| 4| 4| 4| 5| 4| 8| 4|
| 5| 1| 1| 1| 2| 5| 1| 1| 0| 1| 0| 5| 1| 6| 1| 1| 6| 0| 1| 1| 1| 6| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | |
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Harderian | |
Gland | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
Gland | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 4| 7| 7| 6| 7| 2| 4| 7| 4| 7| 2| 4| 2| 7| 7| 7| 4| 7| 2| 7|
DAY ON TEST | 5| 4| 8| 4| 4| 5| 4| 4| 9| 4| 8| 5| 4| 5| 4| 8| 5| 8| 4| 4| 4| 5| 4| 8| 4|
| 5| 1| 1| 1| 2| 5| 1| 1| 0| 1| 0| 5| 1| 6| 1| 1| 6| 0| 1| 1| 1| 6| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| | |
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 8| 8| | |
| 1| 0| 1| 1| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 9| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
500 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + M + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 69 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Hepatocellular Carcinoma | X X X X | 5 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X X X | 14 |
Hepatocellular Adenoma, Multiple | X X X X | 15 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 5 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + | 69 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| | |
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 8| 8| | |
| 1| 0| 1| 1| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 9| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
500 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 68 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + + M + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 67 |
Pars Distalis, Adenoma | X X | 9 |
Pars Intermedia, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Follicular Cell, Adenoma | X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M M + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Ovary | + + M + + + + + + + + + + + + + + + + + | 67 |
Cystadenoma | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | X | 1 |
Polyp Stromal | | 1 |
Endometrium, Adenocarcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
Lumbar, Lymphoma Malignant Mixed | X | 4 |
Mediastinal, Lymphoma Malignant Mixed| X | 4 |
Renal, Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + | 68 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + + M + + + + + + + | 67 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| | |
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 8| 8| | |
| 1| 0| 1| 1| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 9| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
500 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X X X | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X X X X X | 9 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 69 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + M M + + + + + + + + + + + | 64 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Alveolar/Bronchiolar Adenoma | X X | 6 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| | |
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 8| 8| | |
| 1| 0| 1| 1| 0| 1| 2| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 9| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
500 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
Adenoma | X | 1 |
Carcinoma | X | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangioma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X X X X X X | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 6| 2| 7| 6| 4| 4| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 5| 4| 5| 3| 7| 4| 7| 5| 5| 5| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 1| 1| 4| 1| 5| 9| 4| 1| 9| 4| 5| 5| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + M + + + + + M + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X X X X X |
Hepatocellular Adenoma, Multiple | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + M + + M + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 6| 2| 7| 6| 4| 4| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 5| 4| 5| 3| 7| 4| 7| 5| 5| 5| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 1| 1| 4| 1| 5| 9| 4| 1| 9| 4| 5| 5| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + I + + + + + + + M + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Harderian | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 6| 2| 7| 6| 4| 4| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 5| 4| 5| 3| 7| 4| 7| 5| 5| 5| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 1| 1| 4| 1| 5| 9| 4| 1| 9| 4| 5| 5| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Gland | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 4| 2| 7| 7| 2| 4| 7| 4| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 4|
DAY ON TEST | 7| 4| 7| 4| 5| 7| 4| 4| 7| 5| 4| 5| 4| 4| 4| 7| 4| 4| 4| 4| 7| 4| 4| 4| 5|
| 5| 1| 5| 1| 5| 5| 1| 1| 5| 4| 1| 4| 1| 1| 1| 5| 1| 1| 1| 1| 4| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + M + I M M + M + + + + + + + + + + + + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 4| 2| 7| 7| 2| 4| 7| 4| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 4|
DAY ON TEST | 7| 4| 7| 4| 5| 7| 4| 4| 7| 5| 4| 5| 4| 4| 4| 7| 4| 4| 4| 4| 7| 4| 4| 4| 5|
| 5| 1| 5| 1| 5| 5| 1| 1| 5| 4| 1| 4| 1| 1| 1| 5| 1| 1| 1| 1| 4| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
Iliac, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + M + + + M +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Harderian | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 4| 2| 7| 7| 2| 4| 7| 4| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 4|
DAY ON TEST | 7| 4| 7| 4| 5| 7| 4| 4| 7| 5| 4| 5| 4| 4| 4| 7| 4| 4| 4| 4| 7| 4| 4| 4| 5|
| 5| 1| 5| 1| 5| 5| 1| 1| 5| 4| 1| 4| 1| 1| 1| 5| 1| 1| 1| 1| 4| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Gland | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 7| 2| | |
DAY ON TEST | 4| 5| 4| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 7| 4| 4| 4| 4| 7| | |
| 1| 4| 1| 1| 1| 4| 1| 1| 1| 7| 1| 1| 1| 1| 5| 1| 0| 1| 1| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + A + + + | 64 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + | 69 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + | 67 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + + + + + + + + + A + + + | 66 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangiosarcoma | X X X | 3 |
Hepatocellular Carcinoma | X X X X | 8 |
Hepatocellular Carcinoma, Multiple | | 2 |
Hepatocellular Adenoma | X X X X | 15 |
Hepatocellular Adenoma, Multiple | X | 5 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 69 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + | 68 |
__________________________________________________________________________|____________|
Tongue | + + | 3 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + | 69 |
Adenoma | | 1 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + M + + + + + + M + + + | 68 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + + + + M + M + + + + + M M + + | 52 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Follicular Cell, Adenoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 7| 2| | |
DAY ON TEST | 4| 5| 4| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 7| 4| 4| 4| 4| 7| | |
| 1| 4| 1| 1| 1| 4| 1| 1| 1| 7| 1| 1| 1| 1| 5| 1| 0| 1| 1| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 17 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Iliac, Lymphoma Malignant Mixed | X | 1 |
Inguinal, Lymphoma Malignant Mixed | X | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 1 |
Pancreatic, Lymphoma Malignant Mixed | X | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + M + + + + + + + + + M | 66 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + | 68 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 69 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Thymus | M + + + M + + M + + + M + + + M M + + + | 58 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Sarcoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 7| 2| | |
DAY ON TEST | 4| 5| 4| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 7| 4| 4| 4| 4| 7| | |
| 1| 4| 1| 1| 1| 4| 1| 1| 1| 7| 1| 1| 1| 1| 5| 1| 0| 1| 1| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Alveolar/Bronchiolar Adenoma | X X X X | 13 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X X X X | 4 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 4 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 5 |
Adenoma | X X | 4 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + | 68 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 2| 6| 4| 7| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 2| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 7| 2| 5| 4| 0| 5| 7| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 5| 7| 4| 4|
| 5| 0| 0| 0| 5| 8| 5| 0| 7| 5| 4| 0| 0| 0| 0| 4| 0| 0| 0| 0| 5| 5| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Sarcoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatoblastoma | |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | |
Sarcoma | |
__________________________________________________________________________|
Mesentery | + |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Prostate | X |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + M + + + A + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 2| 6| 4| 7| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 2| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 7| 2| 5| 4| 0| 5| 7| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 5| 7| 4| 4|
| 5| 0| 0| 0| 5| 8| 5| 0| 7| 5| 4| 0| 0| 0| 0| 4| 0| 0| 0| 0| 5| 5| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M + + M M M + + + M M + M + + + + + + + I + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Sarcoma | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + A + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Histiocytic Sarcoma | X |
Mediastinal, Lymphoma Malignant Mixed| X |
Mediastinal, Sarcoma | |
Pancreatic, Sarcoma | |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + I + + + M + M + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + A + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
Sarcoma | |
__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
Sarcoma | |
__________________________________________________________________________|
Thymus | + + + + + A + + + + M + + + + M + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 2| 6| 4| 7| 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 2| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 7| 2| 5| 4| 0| 5| 7| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 5| 7| 4| 4|
| 5| 0| 0| 0| 5| 8| 5| 0| 7| 5| 4| 0| 0| 0| 0| 4| 0| 0| 0| 0| 5| 5| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + M + + + + + + + + +|
Adenocarcinoma, Metastatic, Prostate | X |
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Carcinoma | X X|
Histiocytic Sarcoma | X |
Sarcoma | |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 2|
DAY ON TEST | 7| 7| 7| 7| 7| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 5| 4| 7| 7|
| 4| 4| 4| 4| 4| 0| 0| 0| 5| 0| 0| 1| 1| 1| 1| 1| 1| 1| 0| 8| 0| 4| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Sarcoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatoblastoma | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Sarcoma | |
__________________________________________________________________________|
Mesentery | |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Prostate | |
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 2|
DAY ON TEST | 7| 7| 7| 7| 7| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 5| 4| 7| 7|
| 4| 4| 4| 4| 4| 0| 0| 0| 5| 0| 0| 1| 1| 1| 1| 1| 1| 1| 0| 8| 0| 4| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + M + + M + + + M + + + + + + + + + + + M + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + M +|
Adenocarcinoma | |
Sarcoma | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Lymphoma Malignant Mixed| |
Mediastinal, Sarcoma | |
Pancreatic, Sarcoma | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + M + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X X |
Sarcoma | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Sarcoma | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M M + M + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 2|
DAY ON TEST | 7| 7| 7| 7| 7| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 5| 4| 7| 7|
| 4| 4| 4| 4| 4| 0| 0| 0| 5| 0| 0| 1| 1| 1| 1| 1| 1| 1| 0| 8| 0| 4| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Prostate | |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X X |
Histiocytic Sarcoma | |
Sarcoma | |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 4| 4| 4| 4| 5| 5| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 4| 5| 0| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 69 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 68 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 68 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 68 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangiosarcoma | | 2 |
Hepatoblastoma | X | 1 |
Hepatocellular Carcinoma | X X | 8 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X X X X | 8 |
Hepatocellular Adenoma, Multiple | X X X X | 10 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 69 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenocarcinoma, Metastatic, Prostate | | 1 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 4| 4| 4| 4| 5| 5| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 4| 5| 0| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 69 |
Capsule, Adenoma | X | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + M + + + + + + + + + + + + | 68 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + M M M + M + + + + + + + M M | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 69 |
Adenocarcinoma | | 1 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 69 |
Sarcoma | X X | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
Mediastinal, Histiocytic Sarcoma | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Mediastinal, Sarcoma | X X | 2 |
Pancreatic, Sarcoma | X | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + | 65 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + | 65 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 3 |
Sarcoma | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 4| 4| 4| 4| 5| 5| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 4| 5| 0| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 69 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 2 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + M + + + M + + M + | 60 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + M M M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 69 |
Adenocarcinoma, Metastatic, Prostate | | 1 |
Alveolar/Bronchiolar Adenoma | X | 7 |
Alveolar/Bronchiolar Carcinoma | X | 5 |
Histiocytic Sarcoma | | 1 |
Sarcoma | X | 1 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 4| 4| 4| 4| 5| 5| 2| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 4| 5| 0| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 2| 2| 2| 7| 7| 7| 2| 7| 4| 7| 7| 7| 7| 5| 2| 4| 2| 7| 7| 4| 7| 4| 4| 7|
DAY ON TEST | 3| 7| 7| 7| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 8| 7| 5| 7| 3| 3| 5| 3| 5| 5| 3|
| 7| 4| 5| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 5| 5| 5| 4| 6| 7| 4| 6| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M M + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | |
Hepatoblastoma, Multiple | |
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + + + + + M + + + M + M + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + M + M + + + M + + M + + + + M + + + + + +|
Pars Intermedia, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 2| 2| 2| 7| 7| 7| 2| 7| 4| 7| 7| 7| 7| 5| 2| 4| 2| 7| 7| 4| 7| 4| 4| 7|
DAY ON TEST | 3| 7| 7| 7| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 8| 7| 5| 7| 3| 3| 5| 3| 5| 5| 3|
| 7| 4| 5| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 5| 5| 5| 4| 6| 7| 4| 6| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
__________________________________________________________________________|
Lymph Node | |
Mediastinal, Lymphoma Malignant Mixed| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + I + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hemangiosarcoma | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + M + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + I + + + + + + + +|
Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 2| 2| 2| 7| 7| 7| 2| 7| 4| 7| 7| 7| 7| 5| 2| 4| 2| 7| 7| 4| 7| 4| 4| 7|
DAY ON TEST | 3| 7| 7| 7| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 8| 7| 5| 7| 3| 3| 5| 3| 5| 5| 3|
| 7| 4| 5| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 5| 5| 5| 4| 6| 7| 4| 6| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 2| 7| 7| 4|
DAY ON TEST | 3| 4| 3| 3| 4| 4| 5| 3| 5| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 7| 4| 4| 5|
| 6| 1| 6| 6| 0| 0| 4| 1| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | X |
Hepatoblastoma, Multiple | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + M + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M M M + + M + M + + + + + + M I M + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Pars Intermedia, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 2| 7| 7| 4|
DAY ON TEST | 3| 4| 3| 3| 4| 4| 5| 3| 5| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 7| 4| 4| 5|
| 6| 1| 6| 6| 0| 0| 4| 1| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Lymphoma Malignant Mixed| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
__________________________________________________________________________|
Thymus | + M M + + + + M + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 2| 7| 7| 4|
DAY ON TEST | 3| 4| 3| 3| 4| 4| 5| 3| 5| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 7| 4| 4| 5|
| 6| 1| 6| 6| 0| 0| 4| 1| 4| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 2| 7| 7| 6| 7| | |
DAY ON TEST | 5| 4| 7| 4| 4| 4| 4| 4| 4| 4| 0| 7| 4| 2| 4| 7| 1| 4| 1| 4| | |
| 4| 0| 5| 0| 0| 0| 0| 0| 0| 0| 1| 4| 0| 6| 0| 4| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
250 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + M + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + A + + M + + + + M + | 64 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + A + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + A + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + A + + + | 68 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + A + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + A + + M | 67 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + A + + + | 67 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangioma | | 1 |
Hemangiosarcoma | | 1 |
Hepatoblastoma, Multiple | X | 1 |
Hepatocellular Carcinoma | X X X X X X X X | 15 |
Hepatocellular Carcinoma, Multiple | | 2 |
Hepatocellular Adenoma | X X X | 12 |
Hepatocellular Adenoma, Multiple | X X X | 6 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + M + M + + + M + M M | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 64 |
Pars Intermedia, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 2| 7| 7| 6| 7| | |
DAY ON TEST | 5| 4| 7| 4| 4| 4| 4| 4| 4| 4| 0| 7| 4| 2| 4| 7| 1| 4| 1| 4| | |
| 4| 0| 5| 0| 0| 0| 0| 0| 0| 0| 1| 4| 0| 6| 0| 4| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
250 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + A + + + + M + + + + | 67 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Interstitial Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangiosarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + | 67 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + M + M + | 65 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 69 |
Hemangiosarcoma | | 1 |
__________________________________________________________________________|____________|
Thymus | + M + + M + + + M + + + + + + + + M M + | 58 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 69 |
Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Alveolar/Bronchiolar Adenoma | X | 5 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X X | 2 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 6| 7| 2| 7| 7| 6| 7| | |
DAY ON TEST | 5| 4| 7| 4| 4| 4| 4| 4| 4| 4| 0| 7| 4| 2| 4| 7| 1| 4| 1| 4| | |
| 4| 0| 5| 0| 0| 0| 0| 0| 0| 0| 1| 4| 0| 6| 0| 4| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
250 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 4 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + M + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + + + + A + + + | 68 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 5| 7| 2| 7| 7| 7| 6| 7| 4| 6| 2| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 4| 7| 4| 7|
DAY ON TEST | 7| 3| 7| 3| 3| 3| 8| 3| 5| 5| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 5| 3|
| 4| 0| 5| 0| 3| 0| 7| 6| 5| 4| 4| 4| 6| 6| 3| 3| 3| 3| 3| 5| 3| 4| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + A + + A M + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + A + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X X|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + A + M + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | |
Hepatoblastoma, Multiple | X |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Mesentery | |
Hepatoblastoma, Metastatic, Liver | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M M + M + + + + + + + M + M +|
__________________________________________________________________________|
Pituitary Gland | I + + + + + + M + + + + + + + M + + + + + + + + +|
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 5| 7| 2| 7| 7| 7| 6| 7| 4| 6| 2| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 4| 7| 4| 7|
DAY ON TEST | 7| 3| 7| 3| 3| 3| 8| 3| 5| 5| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 5| 3|
| 4| 0| 5| 0| 3| 0| 7| 6| 5| 4| 4| 4| 6| 6| 3| 3| 3| 3| 3| 5| 3| 4| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Mast Cell Tumor NOS | X |
__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Mast Cell Tumor NOS | X |
__________________________________________________________________________|
Thymus | + I + + + + M + + + + M + M I + M + M + M M + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 5| 7| 2| 7| 7| 7| 6| 7| 4| 6| 2| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 4| 7| 4| 7|
DAY ON TEST | 7| 3| 7| 3| 3| 3| 8| 3| 5| 5| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 5| 3|
| 4| 0| 5| 0| 3| 0| 7| 6| 5| 4| 4| 4| 6| 6| 3| 3| 3| 3| 3| 5| 3| 4| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Harderian | |
Gland | X |
Hepatoblastoma, Metastatic, Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X X|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 2| 2| 7| 7| 7| 6| 7| 7| 4| 7| 2| 7| 2| 7| 2| 4| 7| 4| 4| 7| 7| 2| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 1| 3| 3| 5| 3| 7| 3| 7| 3| 7| 5| 3| 5| 5| 3| 3| 7| 3| 3| 3|
| 5| 5| 3| 6| 6| 8| 5| 5| 4| 6| 5| 6| 4| 5| 5| 4| 5| 5| 5| 3| 3| 5| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | X X |
Hepatoblastoma, Multiple | |
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Mesentery | + |
Hepatoblastoma, Metastatic, Liver | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | I + + + + + + + + + + + + + + + + + + + + I + + M|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + M + M + + + M + M M M M + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + M + + + + + + + + M + + + + + + + +|
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 2| 2| 7| 7| 7| 6| 7| 7| 4| 7| 2| 7| 2| 7| 2| 4| 7| 4| 4| 7| 7| 2| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 1| 3| 3| 5| 3| 7| 3| 7| 3| 7| 5| 3| 5| 5| 3| 3| 7| 3| 3| 3|
| 5| 5| 3| 6| 6| 8| 5| 5| 4| 6| 5| 6| 4| 5| 5| 4| 5| 5| 5| 3| 3| 5| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + M M + + M + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X|
Mast Cell Tumor NOS | |
__________________________________________________________________________|
Lymph Node | |
Lumbar, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + M + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + M + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Mast Cell Tumor NOS | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
_____________________________________________________________________________________________________________________
| 2| 2| 7| 7| 7| 6| 7| 7| 4| 7| 2| 7| 2| 7| 2| 4| 7| 4| 4| 7| 7| 2| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 1| 3| 3| 5| 3| 7| 3| 7| 3| 7| 5| 3| 5| 5| 3| 3| 7| 3| 3| 3|
| 5| 5| 3| 6| 6| 8| 5| 5| 4| 6| 5| 6| 4| 5| 5| 4| 5| 5| 5| 3| 3| 5| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Harderian | |
Gland | |
Hepatoblastoma, Metastatic, Liver | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 3| 7| 3| 5| 3| 5| 3| 3| 4| 3| 3| 0| 3| 2| 3| 3| 3| 0| 3| | |
| 4| 6| 5| 3| 5| 3| 4| 3| 4| 7| 4| 4| 0| 3| 6| 4| 4| 3| 7| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + A + | 62 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + A + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + | 67 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + | 68 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + | 66 |
Lymphoma Malignant Mixed | | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + | 65 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Hepatoblastoma | X X | 4 |
Hepatoblastoma, Multiple | | 1 |
Hepatocellular Carcinoma | X X X X | 11 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X X X X X X | 16 |
Hepatocellular Adenoma, Multiple | X X X X X | 15 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Hepatoblastoma, Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangiosarcoma, Metastatic, Spleen | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Tongue | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + | 66 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 3| 7| 3| 5| 3| 5| 3| 3| 4| 3| 3| 0| 3| 2| 3| 3| 3| 0| 3| | |
| 4| 6| 5| 3| 5| 3| 4| 3| 4| 7| 4| 4| 0| 3| 6| 4| 4| 3| 7| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M + + M M + + + M + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 64 |
Pars Intermedia, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + M + | 54 |
__________________________________________________________________________|____________|
Prostate | + + + + + + M + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 7 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 69 |
Hemangiosarcoma | | 2 |
Mast Cell Tumor NOS | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + A + | 66 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + A + | 65 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangiosarcoma | X | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
Mast Cell Tumor NOS | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + M + M + + + M + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 3| 7| 3| 5| 3| 5| 3| 3| 4| 3| 3| 0| 3| 2| 3| 3| 3| 0| 3| | |
| 4| 6| 5| 3| 5| 3| 4| 3| 4| 7| 4| 4| 0| 3| 6| 4| 4| 3| 7| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M + M M M + M M M M M M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Fibroma | X | 1 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Alveolar/Bronchiolar Adenoma | X X | 5 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | X | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + | 67 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
NTP Experiment-Test: 05150-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/01/97
Route: DOSED FEED Time: 16:31:36
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 8| 3| 7| 3| 5| 3| 5| 3| 3| 4| 3| 3| 0| 3| 2| 3| 3| 3| 0| 3| | |
| 4| 6| 5| 3| 5| 3| 4| 3| 4| 7| 4| 4| 0| 3| 6| 4| 4| 3| 7| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 83
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