TDMS Study 05150-01 Pathology Tables
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 Facility: TSI Mason Research Chemical CAS #: 298-59-9 Lock Date: 02/06/92 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 2| 7| 7| 4| 7| 4| 7| 7| 7| 2| 6| 7| 7| 2| 6| 7| 6| 5| 4| 7| 7| 7| 7| 4| DAY ON TEST | 8| 8| 4| 4| 6| 4| 5| 2| 4| 4| 8| 4| 4| 4| 8| 7| 4| 8| 6| 6| 4| 4| 4| 4| 6| | 2| 2| 8| 6| 3| 8| 0| 9| 8| 8| 1| 8| 8| 8| 2| 7| 8| 0| 3| 4| 8| 8| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X 2 3 2| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | 3 2 4 | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Dilatation | | Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 3 | Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X X | Developmental Malformation | | Fatty Change | 2 | Granuloma | 3 3 | Hemorrhage | 2 | Hepatodiaphragmatic Nodule | X X X X X | Necrosis, Focal | | Pigmentation, Bile | 4 | Bile Duct, Hyperplasia | 1 1 | __________________________________________________________________________| Mesentery | + | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 1 2 2 2 2 2 2 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | 2 2 | Hyperplasia | 2 | Hypoplasia | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 3 | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 3 2 | Hypoplasia | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 2 2 1| Dilatation | 3 | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 2| 7| 7| 4| 7| 4| 7| 7| 7| 2| 6| 7| 7| 2| 6| 7| 6| 5| 4| 7| 7| 7| 7| 4| DAY ON TEST | 8| 8| 4| 4| 6| 4| 5| 2| 4| 4| 8| 4| 4| 4| 8| 7| 4| 8| 6| 6| 4| 4| 4| 4| 6| | 2| 2| 8| 6| 3| 8| 0| 9| 8| 8| 1| 8| 8| 8| 2| 7| 8| 0| 3| 4| 8| 8| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Inflammation, Chronic, Focal | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | 3 2 | Hyperplasia, Focal | | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + M + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Pars Distalis, Angiectasis, Focal | | Pars Distalis, Angiectasis | 3 | Pars Distalis, Cyst | X X X X X X | Pars Distalis, Hyperplasia, Focal | 2 1 | Pars Distalis, Hyperplasia | 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 3 2 2 2 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M + M + + + + + + + + + + + + + + + + + + +| Cyst | X | Dilatation | 3 3 | Inflammation, Acute | | Inflammation, Chronic, Focal | | Inflammation, Chronic | 2 1 3 3 1| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic, Focal | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Dilatation | 1 1 | Endometrium, Cyst | | Endometrium, Fibrosis | | Endometrium, Hyperplasia, Cystic | 2 | __________________________________________________________________________| Vagina | | Dilatation | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 2| 7| 7| 4| 7| 4| 7| 7| 7| 2| 6| 7| 7| 2| 6| 7| 6| 5| 4| 7| 7| 7| 7| 4| DAY ON TEST | 8| 8| 4| 4| 6| 4| 5| 2| 4| 4| 8| 4| 4| 4| 8| 7| 4| 8| 6| 6| 4| 4| 4| 4| 6| | 2| 2| 8| 6| 3| 8| 0| 9| 8| 8| 1| 8| 8| 8| 2| 7| 8| 0| 3| 4| 8| 8| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 2 2 4 4 | __________________________________________________________________________| Lymph Node | + + | Mediastinal, Congestion | 3 | Pancreatic, Congestion | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Giant Cell | | Infiltration Cellular, Plasma Cell | | Infiltration Cellular, Histiocyte | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Depletion Lymphoid | | Giant Cell | 2 2 2 | Granuloma | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Congestion | | Depletion Lymphoid | | Fibrosis, Focal | 3 | Granuloma | | Hematopoietic Cell Proliferation | 4 3 | Infarct | | Pigmentation, Hemosiderin | | Capsule, Fibrosis | 3 | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Galactocele | X X | Galactocele, Multiple | X | Lactation | 2 2 4 3 4 2 2 3 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | | __________________________________________________________________________| Skeletal Muscle | | Ectopic Tissue | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 2| 7| 7| 4| 7| 4| 7| 7| 7| 2| 6| 7| 7| 2| 6| 7| 6| 5| 4| 7| 7| 7| 7| 4| DAY ON TEST | 8| 8| 4| 4| 6| 4| 5| 2| 4| 4| 8| 4| 4| 4| 8| 7| 4| 8| 6| 6| 4| 4| 4| 4| 6| | 2| 2| 8| 6| 3| 8| 0| 9| 8| 8| 1| 8| 8| 8| 2| 7| 8| 0| 3| 4| 8| 8| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | | Congestion | | Hemorrhage | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma | | Necrosis, Focal | | Alveolar Epithelium, Metaplasia | 2 3 | Peribronchial, Inflammation, Chronic | 2 2 2 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | 4 | Inflammation, Acute | | Inflammation, Chronic, Focal | 2 2 1 2 | Inflammation, Chronic | 3 2 2 2| Metaplasia, Squamous | 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | | Retina, Degeneration | | __________________________________________________________________________| Harderian Gland | + | Hyperplasia | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | 3 | Mineralization | 2 1 2 2 | Nephropathy | 2 2 1 2 1 3 2 4 2 2 1 1 2 1 1| Renal Tubule, Degeneration, Granular | | Renal Tubule, Necrosis, Focal | 2 | Renal Tubule, Pigmentation, Bile | 3 3 | Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | 1 | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 4| 7| 4| 4| 7| 7| 2| 6| 2| 7| 7| 4| 6| 7| 7| 7| 4| 6| 2| 5| 7| 2| 7| 7| DAY ON TEST | 6| 6| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 6| 6| 2| 4| 4| 6| 6| 8| 5| 4| 6| 4| 4| | 3| 3| 7| 3| 4| 7| 7| 2| 0| 1| 7| 7| 3| 0| 8| 7| 7| 3| 2| 1| 1| 7| 0| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| Parasite Metazoan | 2 2 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | 2 2 2 | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A + + + + A + + + + + + + + + + +| Autolysis | 3 | Dilatation | 3 | Parasite Metazoan | 4 4 3 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + + + A + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 | Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X| Clear Cell Focus | X X | Developmental Malformation | | Fatty Change | 4 3 2 | Granuloma | 2 | Hemorrhage | | Hepatodiaphragmatic Nodule | | Necrosis, Focal | | Pigmentation, Bile | | Bile Duct, Hyperplasia | 2 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 4 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | | Hyperplasia | | Hypoplasia | 2 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 3 | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 4 | Hypoplasia | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 2 3 2 1 2 1 1 3 1 1 3 3 | Dilatation | | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 4| 7| 4| 4| 7| 7| 2| 6| 2| 7| 7| 4| 6| 7| 7| 7| 4| 6| 2| 5| 7| 2| 7| 7| DAY ON TEST | 6| 6| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 6| 6| 2| 4| 4| 6| 6| 8| 5| 4| 6| 4| 4| | 3| 3| 7| 3| 4| 7| 7| 2| 0| 1| 7| 7| 3| 0| 8| 7| 7| 3| 2| 1| 1| 7| 0| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Inflammation, Chronic, Focal | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | 2 | Hyperplasia, Focal | 2 | Vacuolization Cytoplasmic | 3 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Pars Distalis, Angiectasis, Focal | 2 | Pars Distalis, Angiectasis | 4 3 4 3 | Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia, Focal | 2 4 3 3 1 3| Pars Distalis, Hyperplasia | 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 1 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X | Dilatation | 3 4 3 3| Inflammation, Acute | 2 | Inflammation, Chronic, Focal | 2 2 1 | Inflammation, Chronic | 1 2 2 1 2 1 1 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic, Focal | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 | Dilatation | 3 2 3 | Endometrium, Cyst | | Endometrium, Fibrosis | 2 | Endometrium, Hyperplasia, Cystic | | __________________________________________________________________________| Vagina | | Dilatation | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 4| 7| 4| 4| 7| 7| 2| 6| 2| 7| 7| 4| 6| 7| 7| 7| 4| 6| 2| 5| 7| 2| 7| 7| DAY ON TEST | 6| 6| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 6| 6| 2| 4| 4| 6| 6| 8| 5| 4| 6| 4| 4| | 3| 3| 7| 3| 4| 7| 7| 2| 0| 1| 7| 7| 3| 0| 8| 7| 7| 3| 2| 1| 1| 7| 0| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 4 4 3 | __________________________________________________________________________| Lymph Node | + + | Mediastinal, Congestion | | Pancreatic, Congestion | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Giant Cell | 2 | Infiltration Cellular, Plasma Cell | | Infiltration Cellular, Histiocyte | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Depletion Lymphoid | 4 | Giant Cell | 2 1 3 2 | Granuloma | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Congestion | | Depletion Lymphoid | 3 2 | Fibrosis, Focal | | Granuloma | 4 | Hematopoietic Cell Proliferation | 4 4 | Infarct | | Pigmentation, Hemosiderin | 2 | Capsule, Fibrosis | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 4 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | X X X | Galactocele, Multiple | | Lactation | 3 2 3 4 3 2 3 2 2 4 3| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 3 3 | __________________________________________________________________________| Skeletal Muscle | + | Ectopic Tissue | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 4| 7| 4| 4| 7| 7| 2| 6| 2| 7| 7| 4| 6| 7| 7| 7| 4| 6| 2| 5| 7| 2| 7| 7| DAY ON TEST | 6| 6| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 6| 6| 2| 4| 4| 6| 6| 8| 5| 4| 6| 4| 4| | 3| 3| 7| 3| 4| 7| 7| 2| 0| 1| 7| 7| 3| 0| 8| 7| 7| 3| 2| 1| 1| 7| 0| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 4 3 3 | Congestion | 1 | Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma | | Necrosis, Focal | 4 3 | Alveolar Epithelium, Metaplasia | | Peribronchial, Inflammation, Chronic | 2 1 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | 3 4 | Inflammation, Acute | 3 4 | Inflammation, Chronic, Focal | 2 2 2 | Inflammation, Chronic | 2 2 1 2 2 | Metaplasia, Squamous | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | | Retina, Degeneration | | __________________________________________________________________________| Harderian Gland | + | Hyperplasia | 2 | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | 2 | Mineralization | 1 2 1 2 4 2| Nephropathy | 2 1 2 2 2 1 3 1 2 4 1 2 1 2 2 3 1| Renal Tubule, Degeneration, Granular | | Renal Tubule, Necrosis, Focal | | Renal Tubule, Pigmentation, Bile | 3 | Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +| Inflammation, Chronic, Focal | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 5| 2| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| | | DAY ON TEST | 6| 7| 1| 7| 8| 4| 4| 8| 4| 4| 5| 4| 8| 4| 4| 4| 6| 8| 4| 4| | | | 4| 5| 3| 5| 2| 7| 7| 4| 7| 7| 0| 9| 2| 7| 7| 7| 8| 1| 7| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + A + + + A + + + + + + + + + + + + | 67 | Parasite Metazoan | 2 3 | 8 2.3| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + | 69 | Parasite Metazoan | 3 | 7 2.6| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + A + + + + + + + + + + + + | 66 | Autolysis | | 1 3.0| Dilatation | | 1 3.0| Parasite Metazoan | | 3 3.7| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + A + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + A + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + A + + + + + + + + + + + + | 66 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Abscess | | 2 3.5| Angiectasis | 2 | 1 2.0| Basophilic Focus | X X X X X X X X X X | 42 | Clear Cell Focus | X X X X | 11 | Developmental Malformation | X | 1 | Fatty Change | 3 3 4 3 | 8 3.0| Granuloma | | 3 2.7| Hemorrhage | | 1 2.0| Hepatodiaphragmatic Nodule | X X | 7 | Necrosis, Focal | 3 | 1 3.0| Pigmentation, Bile | | 1 4.0| Bile Duct, Hyperplasia | 1 | 4 1.3| __________________________________________________________________________|____________| Mesentery | + | 4 | Fat, Necrosis | 4 | 3 3.3| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 | Acinus, Atrophy | 3 4 | 13 2.1| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | Depletion Cellular | | 2 2.0| Hyperplasia | | 1 2.0| Hypoplasia | | 1 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperplasia, Squamous | | 2 3.0| Ulcer | 4 | 1 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 | Erosion | 4 3 | 5 3.2| Hypoplasia | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 5| 2| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| | | DAY ON TEST | 6| 7| 1| 7| 8| 4| 4| 8| 4| 4| 5| 4| 8| 4| 4| 4| 6| 8| 4| 4| | | | 4| 5| 3| 5| 2| 7| 7| 4| 7| 7| 0| 9| 2| 7| 7| 7| 8| 1| 7| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | Cardiomyopathy | 4 2 2 2 3 3 | 25 2.0| Dilatation | | 1 3.0| Inflammation, Chronic, Focal | 1 | 2 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 | Cytoplasmic Alteration, Focal | | 3 2.3| Hyperplasia, Focal | | 1 2.0| Vacuolization Cytoplasmic | 3 | 3 2.7| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperplasia, Focal | 4 2 | 7 2.1| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + | 67 | Hyperplasia, Focal | 2 2 | 2 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 70 | Hemorrhage | | 1 3.0| Pars Distalis, Angiectasis, Focal | | 1 2.0| Pars Distalis, Angiectasis | | 5 3.4| Pars Distalis, Cyst | X X X | 11 | Pars Distalis, Hyperplasia, Focal | 3 3 4 2 4 3 | 14 2.7| Pars Distalis, Hyperplasia | | 2 3.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 | C-Cell, Hyperplasia | 2 2 3 | 14 1.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + M M + + + + + + M + + + + + | 65 | Cyst | X | 4 | Dilatation | 4 4 4 4 | 10 3.5| Inflammation, Acute | 2 3 2 | 4 2.3| Inflammation, Chronic, Focal | 2 2 1 | 6 1.7| Inflammation, Chronic | 1 | 13 1.6| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + | 70 | Cyst | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 5| 2| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| | | DAY ON TEST | 6| 7| 1| 7| 8| 4| 4| 8| 4| 4| 5| 4| 8| 4| 4| 4| 6| 8| 4| 4| | | | 4| 5| 3| 5| 2| 7| 7| 4| 7| 7| 0| 9| 2| 7| 7| 7| 8| 1| 7| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Chronic, Focal | | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 70 | Abscess | | 1 4.0| Dilatation | 3 3 | 7 2.3| Endometrium, Cyst | X | 1 | Endometrium, Fibrosis | | 1 2.0| Endometrium, Hyperplasia, Cystic | 2 | 2 2.0| __________________________________________________________________________|____________| Vagina | + | 1 | Dilatation | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + | 2 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperplasia | 2 3 3 4 4 2 | 17 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + | 8 | Mediastinal, Congestion | | 1 3.0| Pancreatic, Congestion | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 70 | Congestion | | 1 2.0| Giant Cell | | 1 2.0| Infiltration Cellular, Plasma Cell | 4 | 1 4.0| Infiltration Cellular, Histiocyte | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 70 | Congestion | 3 4 | 3 3.3| Depletion Lymphoid | | 1 4.0| Giant Cell | 4 2 2 | 10 2.2| Granuloma | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 70 | Autolysis | 3 | 1 3.0| Congestion | 3 | 1 3.0| Depletion Lymphoid | 2 2 | 4 2.3| Fibrosis, Focal | | 1 3.0| Granuloma | | 1 4.0| Hematopoietic Cell Proliferation | | 4 3.8| Infarct | 4 | 1 4.0| Pigmentation, Hemosiderin | | 1 2.0| Capsule, Fibrosis | | 1 3.0| __________________________________________________________________________|____________| Thymus | + M + + + + + + + + + + + + + + + + + + | 68 | Depletion Lymphoid | | 2 3.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 5| 2| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| | | DAY ON TEST | 6| 7| 1| 7| 8| 4| 4| 8| 4| 4| 5| 4| 8| 4| 4| 4| 6| 8| 4| 4| | | | 4| 5| 3| 5| 2| 7| 7| 4| 7| 7| 0| 9| 2| 7| 7| 7| 8| 1| 7| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 69 | Galactocele | X X X X | 9 | Galactocele, Multiple | | 1 | Lactation | 2 2 2 4 2 4 2 3 3 3 3 4 2 3 3 | 35 2.8| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperkeratosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperostosis | 2 3 3 4 | 6 3.0| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Ectopic Tissue | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | Compression | 3 | 4 3.3| Congestion | | 1 1.0| Hemorrhage | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Granuloma | 2 | 1 2.0| Necrosis, Focal | 4 | 3 3.7| Alveolar Epithelium, Metaplasia | | 2 2.5| Peribronchial, Inflammation, Chronic | 2 2 2 | 10 1.8| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | Fungus | 4 | 4 3.8| Inflammation, Acute | | 2 3.5| Inflammation, Chronic, Focal | 2 2 2 | 10 1.9| Inflammation, Chronic | 2 | 10 2.0| Metaplasia, Squamous | | 3 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | + + + | 3 | Retina, Degeneration | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 5| 2| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| | | DAY ON TEST | 6| 7| 1| 7| 8| 4| 4| 8| 4| 4| 5| 4| 8| 4| 4| 4| 6| 8| 4| 4| | | | 4| 5| 3| 5| 2| 7| 7| 4| 7| 7| 0| 9| 2| 7| 7| 7| 8| 1| 7| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 2 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Mineralization, Focal | | 2 2.5| Mineralization | 3 3 4 1 3 1 3 3 2 | 19 2.2| Nephropathy | 1 2 2 1 2 2 3 2 1 1 3 2 3 2 | 46 1.9| Renal Tubule, Degeneration, Granular | 3 | 1 3.0| Renal Tubule, Necrosis, Focal | | 1 2.0| Renal Tubule, Pigmentation, Bile | 2 | 4 2.8| Renal Tubule, Regeneration | 1 | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + A + + + A + + + + + + + + + + + + | 67 | Inflammation, Chronic, Focal | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 2| 2| 4| 7| 4| 7| DAY ON TEST | 2| 6| 5| 4| 1| 4| 4| 4| 4| 4| 8| 4| 6| 4| 6| 4| 4| 4| 2| 8| 8| 9| 4| 6| 4| | 1| 3| 0| 3| 2| 3| 3| 3| 4| 3| 5| 3| 0| 3| 4| 1| 4| 4| 8| 1| 2| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | __________________________________________________________________________| Intestine Large, Colon | + + + + A + + + + + + + + + + A + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + A + + + + + + + + + + A + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + + + + + + + + A + + + + + A + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + A + + + + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + A + + + + + A + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + + + + A + + + + + A + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X | Clear Cell Focus | X X X X | Depletion Glycogen | | Developmental Malformation | X | Fatty Change | 1 | Granuloma | 3 4 | Hemorrhage | | Hepatodiaphragmatic Nodule | X | Necrosis, Focal | 4 2| Bile Duct, Hyperplasia | | __________________________________________________________________________| Mesentery | + + + | Inflammation, Granulomatous | | Fat, Necrosis | 3 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +| Ectopic Liver | | Acinus, Atrophy | 2 2 2 4 4 2 3| Acinus, Hyperplasia, Focal | 2 | Artery, Inflammation, Chronic | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + + + + +| Hyperkeratosis | 3 | Inflammation, Subacute | 3 | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + + +| Depletion Cellular | 3 | Erosion | 2 3| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 2 3 2 2 | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 2| 2| 4| 7| 4| 7| DAY ON TEST | 2| 6| 5| 4| 1| 4| 4| 4| 4| 4| 8| 4| 6| 4| 6| 4| 4| 4| 2| 8| 8| 9| 4| 6| 4| | 1| 3| 0| 3| 2| 3| 3| 3| 4| 3| 5| 3| 0| 3| 4| 1| 4| 4| 8| 1| 2| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Inflammation, Chronic, Focal | | Pigmentation | 3 | Coronary Artery, Inflammation, | | Chronic | 3 | Myocardium, Inflammation, Chronic, | | Focal | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + A + + + + + + + + +| Cytoplasmic Alteration, Focal | 2 3 4| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + A + + + + + + + + +| Fibrosis | | Hyperplasia, Focal | 1 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +| Hyperplasia | 1 | Hypoplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + M| Hyperplasia, Focal | | Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + A + + + + + + + + +| Hemorrhage | | Pars Distalis, Angiectasis | 2 | Pars Distalis, Cyst | X | Pars Distalis, Hyperplasia, Focal | 3 2 2 2 1 3 3 4| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 2 2 3 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 2 | Cyst | X | Depletion Cellular | | Dilatation | | Inflammation, Acute | | Inflammation, Chronic, Focal | 2 2 | Inflammation, Chronic | 2 1 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 4 3 | Thrombosis | | Endometrium, Cyst | X | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 2| 2| 4| 7| 4| 7| DAY ON TEST | 2| 6| 5| 4| 1| 4| 4| 4| 4| 4| 8| 4| 6| 4| 6| 4| 4| 4| 2| 8| 8| 9| 4| 6| 4| | 1| 3| 0| 3| 2| 3| 3| 3| 4| 3| 5| 3| 0| 3| 4| 1| 4| 4| 8| 1| 2| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Vagina | | Exudate | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 2 3 2 4| Myelofibrosis | 1 | __________________________________________________________________________| Lymph Node | + + +| Mediastinal, Angiectasis | | Pancreatic, Angiectasis | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Cyst | X | Giant Cell | | Inflammation, Acute | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + A + + + + + + + + +| Congestion | | Giant Cell | 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +| Depletion Lymphoid | 2 | Fibrosis, Focal | | Hematopoietic Cell Proliferation | 4 | Necrosis, Focal | 3| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +| Depletion Lymphoid | 2 | Lymphatic, Angiectasis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | X X X | Galactocele, Multiple | | Lactation | 4 3 3 2 2 3 3 4 4 2 3 4 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | X 2 4 | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X 4 | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 2| 2| 4| 7| 4| 7| DAY ON TEST | 2| 6| 5| 4| 1| 4| 4| 4| 4| 4| 8| 4| 6| 4| 6| 4| 4| 4| 2| 8| 8| 9| 4| 6| 4| | 1| 3| 0| 3| 2| 3| 3| 3| 4| 3| 5| 3| 0| 3| 4| 1| 4| 4| 8| 1| 2| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Hemorrhage | 3| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Peribronchial, Inflammation, Chronic | 2 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | | Inflammation, Acute | | Inflammation, Chronic, Focal | 2 2 | Inflammation, Chronic | 1 2 2 2 | Metaplasia, Squamous | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 2 | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + A + + +| Cyst | X | Glomerulosclerosis | | Mineralization, Focal | 1 | Mineralization | 1 1 2 2 3 2 1 2 1 2 3 1 | Nephropathy | 3 2 1 2 2 2 2 1 2 1 2 3 1 2 1 1 3 1 | Renal Tubule, Degeneration, Granular | | Renal Tubule, Pigmentation, Bile | 2 2 3| Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + + A + + + + + + + + + + A + + + + + A + + +| Hyperplasia, Focal | 3 | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 2| 7| 2| 2| 4| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 4| 7| 4| 4| 7| 6| 7| 2| 7| DAY ON TEST | 8| 8| 4| 8| 8| 6| 6| 4| 7| 3| 2| 4| 4| 8| 4| 2| 6| 4| 6| 6| 4| 8| 4| 8| 4| | 2| 1| 4| 2| 1| 4| 3| 4| 1| 2| 9| 3| 4| 2| 4| 0| 4| 4| 4| 4| 4| 1| 7| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| Parasite Metazoan | 2 2 2 2 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | 2 4 4 2 | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +| Parasite Metazoan | X 2 4| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A A + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Basophilic Focus | X X X X X X X X X X X X X X X| Clear Cell Focus | X X X | Depletion Glycogen | 2 | Developmental Malformation | | Fatty Change | 3 4 2 | Granuloma | 1 2 | Hemorrhage | 3 | Hepatodiaphragmatic Nodule | | Necrosis, Focal | 1 2 2 | Bile Duct, Hyperplasia | 2 | __________________________________________________________________________| Mesentery | + + + + | Inflammation, Granulomatous | 2 | Fat, Necrosis | 4 3 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Liver | X | Acinus, Atrophy | 1 2 | Acinus, Hyperplasia, Focal | | Artery, Inflammation, Chronic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | | __________________________________________________________________________| Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Inflammation, Subacute | | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | | Erosion | 2 4 3 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 3 2 2 1 1 1 1 1 | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 2| 7| 2| 2| 4| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 4| 7| 4| 4| 7| 6| 7| 2| 7| DAY ON TEST | 8| 8| 4| 8| 8| 6| 6| 4| 7| 3| 2| 4| 4| 8| 4| 2| 6| 4| 6| 6| 4| 8| 4| 8| 4| | 2| 1| 4| 2| 1| 4| 3| 4| 1| 2| 9| 3| 4| 2| 4| 0| 4| 4| 4| 4| 4| 1| 7| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Inflammation, Chronic, Focal | 1 1 1 | Pigmentation | | Coronary Artery, Inflammation, | | Chronic | | Myocardium, Inflammation, Chronic, | | Focal | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | 2 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hyperplasia, Focal | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Hypoplasia | 1 3| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + M| Hyperplasia, Focal | | Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Pars Distalis, Angiectasis | 2 3 | Pars Distalis, Cyst | X X X | Pars Distalis, Hyperplasia, Focal | 1 3 2 3 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 4 4 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Abscess | 2 4 | Cyst | X X X | Depletion Cellular | 3 | Dilatation | 4 | Inflammation, Acute | 2 3 | Inflammation, Chronic, Focal | 1 2 1 2 | Inflammation, Chronic | 2 2 2 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 4 | Thrombosis | X | Endometrium, Cyst | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 2| 7| 2| 2| 4| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 4| 7| 4| 4| 7| 6| 7| 2| 7| DAY ON TEST | 8| 8| 4| 8| 8| 6| 6| 4| 7| 3| 2| 4| 4| 8| 4| 2| 6| 4| 6| 6| 4| 8| 4| 8| 4| | 2| 1| 4| 2| 1| 4| 3| 4| 1| 2| 9| 3| 4| 2| 4| 0| 4| 4| 4| 4| 4| 1| 7| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Vagina | + | Exudate | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 3 2 | Myelofibrosis | 1 4 | __________________________________________________________________________| Lymph Node | + | Mediastinal, Angiectasis | 3 | Pancreatic, Angiectasis | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Cyst | | Giant Cell | 2 | Inflammation, Acute | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Giant Cell | 4 1 2 1 3 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | Fibrosis, Focal | 3 | Hematopoietic Cell Proliferation | 4 | Necrosis, Focal | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | Lymphatic, Angiectasis | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | | Galactocele, Multiple | | Lactation | 4 4 4 3 3 3 2 3 4 2 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 | Cyst Epithelial Inclusion | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 4 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 3 4 | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 2| 7| 2| 2| 4| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 4| 7| 4| 4| 7| 6| 7| 2| 7| DAY ON TEST | 8| 8| 4| 8| 8| 6| 6| 4| 7| 3| 2| 4| 4| 8| 4| 2| 6| 4| 6| 6| 4| 8| 4| 8| 4| | 2| 1| 4| 2| 1| 4| 3| 4| 1| 2| 9| 3| 4| 2| 4| 0| 4| 4| 4| 4| 4| 1| 7| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 | Peribronchial, Inflammation, Chronic | 2 2 1 2 2 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | 2 | Inflammation, Acute | | Inflammation, Chronic, Focal | 2 2 2 2 2 2 | Inflammation, Chronic | 3 2 2 2 1 2 | Metaplasia, Squamous | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cataract | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Glomerulosclerosis | | Mineralization, Focal | 1 1 1 1 | Mineralization | 1 1 1| Nephropathy | 2 2 2 3 1 1 2 4 1 3 2 2 2 1 2 3 1| Renal Tubule, Degeneration, Granular | 2 | Renal Tubule, Pigmentation, Bile | 2 2 | Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + + +| Hyperplasia, Focal | | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 7| 7| 7| 5| 7| 6| 7| | | DAY ON TEST | 4| 6| 8| 4| 4| 4| 1| 4| 1| 6| 8| 8| 4| 4| 4| 4| 7| 4| 9| 1| | | | 4| 3| 2| 7| 7| 7| 9| 4| 3| 4| 8| 1| 7| 7| 7| 4| 9| 7| 9| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 100 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 67 | Parasite Metazoan | X 4 2 | 7 2.3| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + | 67 | Parasite Metazoan | | 5 3.0| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + | 65 | Parasite Metazoan | | 3 3.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + | 66 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + A + + + + + + + + A | 63 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + A | 63 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Atrophy | | 1 2.0| Basophilic Focus | X X X X X X X X X X X X X | 48 | Clear Cell Focus | X | 8 | Depletion Glycogen | | 1 2.0| Developmental Malformation | | 1 | Fatty Change | 4 4 | 6 3.0| Granuloma | 2 | 5 2.4| Hemorrhage | | 1 3.0| Hepatodiaphragmatic Nodule | X X | 3 | Necrosis, Focal | | 5 2.2| Bile Duct, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Mesentery | | 7 | Inflammation, Granulomatous | | 1 2.0| Fat, Necrosis | | 6 3.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 | Ectopic Liver | X | 2 | Acinus, Atrophy | 2 1 | 11 2.3| Acinus, Hyperplasia, Focal | | 1 2.0| Artery, Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | Inflammation, Chronic, Focal | 1 2 | 2 1.5| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 68 | Hyperkeratosis | | 1 3.0| Inflammation, Subacute | | 1 3.0| Ulcer | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 69 | Depletion Cellular | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 7| 7| 7| 5| 7| 6| 7| | | DAY ON TEST | 4| 6| 8| 4| 4| 4| 1| 4| 1| 6| 8| 8| 4| 4| 4| 4| 7| 4| 9| 1| | | | 4| 3| 2| 7| 7| 7| 9| 4| 3| 4| 8| 1| 7| 7| 7| 4| 9| 7| 9| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 100 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Erosion | 4 2 | 8 2.9| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | Cardiomyopathy | 3 1 4 2 1 2 2 2 | 23 1.9| Inflammation, Chronic, Focal | 1 1 | 5 1.0| Pigmentation | | 1 3.0| Coronary Artery, Inflammation, | | | Chronic | | 1 3.0| Myocardium, Inflammation, Chronic, | | | Focal | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 69 | Cytoplasmic Alteration, Focal | 3 2 3 | 8 2.8| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 69 | Fibrosis | 4 | 1 4.0| Hyperplasia, Focal | 2 3 | 4 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 | Hyperplasia | | 1 1.0| Hypoplasia | | 2 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 66 | Hyperplasia, Focal | 2 | 1 2.0| Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 69 | Hemorrhage | 4 | 1 4.0| Pars Distalis, Angiectasis | | 3 2.3| Pars Distalis, Cyst | X X X | 7 | Pars Distalis, Hyperplasia, Focal | 4 2 1 | 16 2.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 | C-Cell, Hyperplasia | 1 2 | 12 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + M + + + + + + + + + + + + + + | 68 | Abscess | 3 | 4 2.8| Cyst | | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 7| 7| 7| 5| 7| 6| 7| | | DAY ON TEST | 4| 6| 8| 4| 4| 4| 1| 4| 1| 6| 8| 8| 4| 4| 4| 4| 7| 4| 9| 1| | | | 4| 3| 2| 7| 7| 7| 9| 4| 3| 4| 8| 1| 7| 7| 7| 4| 9| 7| 9| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 100 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Depletion Cellular | 2 | 2 2.5| Dilatation | 4 3 3 | 4 3.5| Inflammation, Acute | | 2 2.5| Inflammation, Chronic, Focal | 2 2 | 8 1.8| Inflammation, Chronic | 3 | 8 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 70 | Dilatation | 3 | 6 3.0| Thrombosis | X | 2 | Endometrium, Cyst | | 1 | __________________________________________________________________________|____________| Vagina | | 1 | Exudate | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperplasia | 4 2 3 | 11 3.0| Myelofibrosis | | 3 2.0| __________________________________________________________________________|____________| Lymph Node | + + | 6 | Mediastinal, Angiectasis | | 1 3.0| Pancreatic, Angiectasis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 70 | Congestion | | 1 3.0| Cyst | | 1 | Giant Cell | | 1 2.0| Inflammation, Acute | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 69 | Congestion | 3 | 1 3.0| Giant Cell | 2 2 | 10 2.2| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 69 | Depletion Lymphoid | | 1 2.0| Fibrosis, Focal | | 1 3.0| Hematopoietic Cell Proliferation | | 2 4.0| Necrosis, Focal | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + M + + + + | 68 | Depletion Lymphoid | 4 | 2 3.0| Lymphatic, Angiectasis | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 7| 7| 7| 5| 7| 6| 7| | | DAY ON TEST | 4| 6| 8| 4| 4| 4| 1| 4| 1| 6| 8| 8| 4| 4| 4| 4| 7| 4| 9| 1| | | | 4| 3| 2| 7| 7| 7| 9| 4| 3| 4| 8| 1| 7| 7| 7| 4| 9| 7| 9| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 100 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Galactocele | X X | 5 | Galactocele, Multiple | X | 1 | Lactation | 2 3 4 2 3 3 3 2 2 2 4 2 | 36 2.9| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 70 | Acanthosis | | 1 3.0| Cyst Epithelial Inclusion | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperostosis | 4 3 3 3 | 9 3.1| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | Compression | 2 | 6 3.3| Hemorrhage | 4 1 2 | 4 2.5| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis | | 2 2.0| Peribronchial, Inflammation, Chronic | 2 1 | 10 1.8| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | Fungus | 4 2 3 | 4 2.8| Inflammation, Acute | 2 | 1 2.0| Inflammation, Chronic, Focal | 2 2 | 10 2.0| Inflammation, Chronic | 2 2 | 12 1.9| Metaplasia, Squamous | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Cataract | | 1 2.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 69 | Cyst | | 1 | Glomerulosclerosis | 4 2 | 2 3.0| Mineralization, Focal | | 5 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 7| 7| 7| 5| 7| 6| 7| | | DAY ON TEST | 4| 6| 8| 4| 4| 4| 1| 4| 1| 6| 8| 8| 4| 4| 4| 4| 7| 4| 9| 1| | | | 4| 3| 2| 7| 7| 7| 9| 4| 3| 4| 8| 1| 7| 7| 7| 4| 9| 7| 9| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 100 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Mineralization | 1 2 3 2 1 1 1 | 22 1.6| Nephropathy | 2 2 1 3 2 1 2 1 2 3 1 1 3 1 | 49 1.9| Renal Tubule, Degeneration, Granular | | 1 2.0| Renal Tubule, Pigmentation, Bile | 4 | 6 2.5| Renal Tubule, Regeneration | 1 1 | 2 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + A + A + + + + + + + + + | 64 | Hyperplasia, Focal | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 6| 2| 4| 7| 4| 2| 5| 7| 7| 4| 4| 7| 7| 2| 4| 2| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 7| 8| 6| 4| 6| 8| 6| 4| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 8| 4| 4| 4| 4| 4| | 5| 5| 1| 3| 2| 3| 1| 7| 2| 2| 3| 4| 2| 2| 2| 4| 1| 2| 2| 8| 2| 2| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | 3 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | Angiectasis | 2 2 | Basophilic Focus | X X X X X X X X X X X X X X X X| Clear Cell Focus | | Eosinophilic Focus | | Fatty Change | | Granuloma | 1 1 2 | Hepatodiaphragmatic Nodule | | Bile Duct, Hyperplasia | 1 1 2 | __________________________________________________________________________| Mesentery | + + + +| Fat, Necrosis | 4 4 2 4| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 2 2 4 2 3 2 2 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | | Erosion | | Ulcer | 4 | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 3 1 2 1 2| Inflammation, Chronic, Focal | 1 | Artery, Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 6| 2| 4| 7| 4| 2| 5| 7| 7| 4| 4| 7| 7| 2| 4| 2| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 7| 8| 6| 4| 6| 8| 6| 4| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 8| 4| 4| 4| 4| 4| | 5| 5| 1| 3| 2| 3| 1| 7| 2| 2| 3| 4| 2| 2| 2| 4| 1| 2| 2| 8| 2| 2| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Cytoplasmic Alteration, Focal | 2 4 4 | Hyperplasia, Focal | | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypoplasia | 3 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 3 | Pars Distalis, Cyst | X X X X X | Pars Distalis, Hyperplasia, Focal | 2 4 2 4 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 4 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Dilatation | 3 | Inflammation, Acute | 3 2 | Inflammation, Chronic, Focal | 1 2 2 | Inflammation, Chronic | 2 2 2 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Cyst | X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Atrophy | | Dilatation | 2 3 3 2 2 | Thrombosis | | Endometrium, Fibrosis | | Endometrium, Hyperplasia, Cystic | 2 | __________________________________________________________________________| Vagina | + + | Dilatation | 3 | Exudate | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + | Hypochromasia | X | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 3 4 3 | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 6| 2| 4| 7| 4| 2| 5| 7| 7| 4| 4| 7| 7| 2| 4| 2| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 7| 8| 6| 4| 6| 8| 6| 4| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 8| 4| 4| 4| 4| 4| | 5| 5| 1| 3| 2| 3| 1| 7| 2| 2| 3| 4| 2| 2| 2| 4| 1| 2| 2| 8| 2| 2| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Myelofibrosis | | __________________________________________________________________________| Lymph Node | + | Lumbar, Hyperplasia | | Mediastinal, Angiectasis | | Mediastinal, Congestion | 3 | Mediastinal, Hematopoietic Cell | | Proliferation | | Mediastinal, Lymphatic, Angiectasis | | Pancreatic, Granuloma | | Pancreatic, Lymphatic, Angiectasis | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Giant Cell | 2 | Infiltration Cellular, Plasma Cell | 4 | Lymphatic, Angiectasis | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Giant Cell | 3 2 3 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 2 | Fibrosis, Focal | | Granuloma | | Hematopoietic Cell Proliferation | 4 | Infarct | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 4 | Hyperplasia | 1 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| Galactocele | | Lactation | 3 4 2 2 2 3 4 3 4 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hyperkeratosis | | Perivascular, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 3 4 X | __________________________________________________________________________| Skeletal Muscle | + | Ectopic Tissue | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 6| 2| 4| 7| 4| 2| 5| 7| 7| 4| 4| 7| 7| 2| 4| 2| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 7| 8| 6| 4| 6| 8| 6| 4| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 8| 4| 4| 4| 4| 4| | 5| 5| 1| 3| 2| 3| 1| 7| 2| 2| 3| 4| 2| 2| 2| 4| 1| 2| 2| 8| 2| 2| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X | Hemorrhage | 3 | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 | Congestion | | Emphysema, Focal | | Hemorrhage, Focal | | Alveolar Epithelium, Metaplasia | | Peribronchial, Inflammation, Chronic | 2 2 2 2 | Pleura, Fibrosis, Focal | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | | Inflammation, Acute | 2| Inflammation, Chronic, Focal | 2 2 2 2 | Inflammation, Chronic | 3 2 2 2 2 2 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +| Cyst | | Mineralization, Focal | 1 | Mineralization | 2 2 2 2 2 2 2 2 | Nephropathy | 2 1 1 2 2 2 1 2 1 2 1 2 2 2 2| Renal Tubule, Degeneration, Granular | | Renal Tubule, Pigmentation, Bile | | Renal Tubule, Regeneration | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 2| 2| 4| 7| 6| 2| 7| 7| 7| 7| 4| 7| 2| 5| 7| 6| 7| 7| 7| 5| 2| DAY ON TEST | 4| 3| 6| 4| 8| 8| 6| 4| 7| 8| 4| 4| 4| 4| 6| 4| 8| 4| 4| 3| 4| 3| 4| 8| 8| | 2| 0| 3| 2| 8| 1| 6| 2| 5| 2| 2| 2| 2| 2| 4| 3| 2| 6| 3| 8| 3| 0| 3| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| Parasite Metazoan | X 3 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | 2 4 | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Ileum | + + + + A + A + + + + + + + + + + + + + + + + A +| Parasite Metazoan | X| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | | Angiectasis | 3 2 | Basophilic Focus | X X X X X X X X X X X | Clear Cell Focus | X | Eosinophilic Focus | X | Fatty Change | 2 4 2 | Granuloma | 1 2 2 1 | Hepatodiaphragmatic Nodule | X X | Bile Duct, Hyperplasia | 1 1 | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 2 3 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 3 2 2 3 1 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | | Erosion | 3 3 2 | Ulcer | | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 3 2 | Inflammation, Chronic, Focal | 1 1 1 | Artery, Mineralization | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 4 | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 2| 2| 4| 7| 6| 2| 7| 7| 7| 7| 4| 7| 2| 5| 7| 6| 7| 7| 7| 5| 2| DAY ON TEST | 4| 3| 6| 4| 8| 8| 6| 4| 7| 8| 4| 4| 4| 4| 6| 4| 8| 4| 4| 3| 4| 3| 4| 8| 8| | 2| 0| 3| 2| 8| 1| 6| 2| 5| 2| 2| 2| 2| 2| 4| 3| 2| 6| 3| 8| 3| 0| 3| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Cytoplasmic Alteration, Focal | 3 3 2 2 2 | Hyperplasia, Focal | 4 | Vacuolization Cytoplasmic | 4 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypoplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 3 | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia, Focal | 3 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 3 2 1 4 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Cyst | | Dilatation | 3 | Inflammation, Acute | 2 | Inflammation, Chronic, Focal | 2 2 2 1| Inflammation, Chronic | 3 2 2 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Cyst | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Atrophy | 2 | Dilatation | 3 4 3 3 | Thrombosis | | Endometrium, Fibrosis | 4 | Endometrium, Hyperplasia, Cystic | | __________________________________________________________________________| Vagina | + | Dilatation | | Exudate | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | Hypochromasia | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 4 3 2 2 3 3 2 | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 2| 2| 4| 7| 6| 2| 7| 7| 7| 7| 4| 7| 2| 5| 7| 6| 7| 7| 7| 5| 2| DAY ON TEST | 4| 3| 6| 4| 8| 8| 6| 4| 7| 8| 4| 4| 4| 4| 6| 4| 8| 4| 4| 3| 4| 3| 4| 8| 8| | 2| 0| 3| 2| 8| 1| 6| 2| 5| 2| 2| 2| 2| 2| 4| 3| 2| 6| 3| 8| 3| 0| 3| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + + + | Lumbar, Hyperplasia | 2 | Mediastinal, Angiectasis | | Mediastinal, Congestion | | Mediastinal, Hematopoietic Cell | | Proliferation | | Mediastinal, Lymphatic, Angiectasis | 4 | Pancreatic, Granuloma | | Pancreatic, Lymphatic, Angiectasis | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 4 | Giant Cell | | Infiltration Cellular, Plasma Cell | | Lymphatic, Angiectasis | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| Congestion | 4 4 | Giant Cell | 2 3 3| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 | Fibrosis, Focal | 3 | Granuloma | | Hematopoietic Cell Proliferation | 4 3 4 | Infarct | 4 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | Hyperplasia | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + + + + + + + + + + + M M + + + + + + +| Galactocele | | Lactation | 1 2 3 2 3 3 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + M + + + + + + + +| Fibrosis | 4 | Hyperkeratosis | 4 | Perivascular, Inflammation, Chronic | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 3 4 2 3 2 2 2 | __________________________________________________________________________| Skeletal Muscle | | Ectopic Tissue | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 2| 2| 4| 7| 6| 2| 7| 7| 7| 7| 4| 7| 2| 5| 7| 6| 7| 7| 7| 5| 2| DAY ON TEST | 4| 3| 6| 4| 8| 8| 6| 4| 7| 8| 4| 4| 4| 4| 6| 4| 8| 4| 4| 3| 4| 3| 4| 8| 8| | 2| 0| 3| 2| 8| 1| 6| 2| 5| 2| 2| 2| 2| 2| 4| 3| 2| 6| 3| 8| 3| 0| 3| 8| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + M + + + + + + + + + + + + + + + + + + + +| Compression | X | Hemorrhage | 1 | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Congestion | 3 | Emphysema, Focal | 2 | Hemorrhage, Focal | 3 | Alveolar Epithelium, Metaplasia | 3 | Peribronchial, Inflammation, Chronic | 2 1 2 1| Pleura, Fibrosis, Focal | | __________________________________________________________________________| Nose | + + + + + M + + + + + + + + + + + + + + + + + + +| Fungus | 4 4 | Inflammation, Acute | 2 2 | Inflammation, Chronic, Focal | 2 2 2| Inflammation, Chronic | 2 3 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| Cyst | | Mineralization, Focal | 1 1 1 1| Mineralization | 2 1 1 2 1 1 1 4 | Nephropathy | 1 1 2 2 2 2 2 2 2 2 1 1 1 | Renal Tubule, Degeneration, Granular | 4 | Renal Tubule, Pigmentation, Bile | 3 | Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + A +| _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 4| 7| 7| 2| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 2| 6| | | DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 8| 6| 4| 4| 4| 4| 3| 4| 4| 4| 4| 8| 4| | | | 2| 4| 2| 2| 4| 3| 3| 2| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 69 | Parasite Metazoan | 3 4 2 2 | 7 2.8| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 | Parasite Metazoan | 4 2 | 4 3.0| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 69 | Parasite Metazoan | 2 2 2 | 5 2.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 68 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 67 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis, Focal | | 1 2.0| Angiectasis | | 4 2.3| Basophilic Focus | X X X X X X X X X X X X X X | 41 | Clear Cell Focus | X X X | 4 | Eosinophilic Focus | | 1 | Fatty Change | 2 3 | 5 2.6| Granuloma | | 7 1.4| Hepatodiaphragmatic Nodule | X X X | 5 | Bile Duct, Hyperplasia | | 5 1.2| __________________________________________________________________________|____________| Mesentery | + | 9 | Fat, Necrosis | 3 | 8 3.3| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 | Acinus, Atrophy | 2 3 4 | 18 2.4| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 | Ulcer | | 1 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 | Depletion Cellular | 2 | 1 2.0| Erosion | | 3 2.7| Ulcer | | 1 4.0| __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | Cardiomyopathy | 2 2 1 1 4 1 1 3 1 2 | 24 1.9| Inflammation, Chronic, Focal | 1 1 | 6 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 4| 7| 7| 2| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 2| 6| | | DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 8| 6| 4| 4| 4| 4| 3| 4| 4| 4| 4| 8| 4| | | | 2| 4| 2| 2| 4| 3| 3| 2| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Artery, Mineralization | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 | Congestion | | 1 4.0| Cytoplasmic Alteration, Focal | | 8 2.8| Hyperplasia, Focal | 2 3 | 3 3.0| Vacuolization Cytoplasmic | | 2 3.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperplasia, Focal | | 3 1.7| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 | Hypoplasia | 2 | 2 2.5| __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + M + + + + + + + + + + + + + | 65 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 69 | Pars Distalis, Angiectasis | | 2 3.0| Pars Distalis, Cyst | X X | 7 | Pars Distalis, Hyperplasia, Focal | 2 2 2 2 | 12 2.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 | C-Cell, Hyperplasia | 1 1 3 | 14 1.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | 69 | Cyst | X | 1 | Dilatation | 3 3 3 | 5 3.0| Inflammation, Acute | | 3 2.3| Inflammation, Chronic, Focal | 2 1 | 9 1.7| Inflammation, Chronic | 2 2 3 | 11 2.3| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis | | 1 2.0| Cyst | | 6 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis | 3 | 1 3.0| Atrophy | | 1 2.0| Dilatation | 2 | 10 2.7| Thrombosis | X | 1 | Endometrium, Fibrosis | 2 | 2 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 4| 7| 7| 2| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 2| 6| | | DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 8| 6| 4| 4| 4| 4| 3| 4| 4| 4| 4| 8| 4| | | | 2| 4| 2| 2| 4| 3| 3| 2| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Endometrium, Hyperplasia, Cystic | | 1 2.0| __________________________________________________________________________|____________| Vagina | + | 4 | Dilatation | | 1 3.0| Exudate | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | | 1 | Hypochromasia | | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperplasia | 4 3 | 15 3.0| Myelofibrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + | 12 | Lumbar, Hyperplasia | | 1 2.0| Mediastinal, Angiectasis | 3 | 1 3.0| Mediastinal, Congestion | 4 | 2 3.5| Mediastinal, Hematopoietic Cell | | | Proliferation | 4 | 1 4.0| Mediastinal, Lymphatic, Angiectasis | | 1 4.0| Pancreatic, Granuloma | 4 | 1 4.0| Pancreatic, Lymphatic, Angiectasis | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 70 | Congestion | | 1 4.0| Giant Cell | | 1 2.0| Infiltration Cellular, Plasma Cell | | 1 4.0| Lymphatic, Angiectasis | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + | 68 | Congestion | | 3 3.7| Giant Cell | 3 | 8 2.8| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 70 | Depletion Lymphoid | 2 3 2 | 6 2.2| Fibrosis, Focal | 2 4 | 3 3.0| Granuloma | 4 | 1 4.0| Hematopoietic Cell Proliferation | | 4 3.8| Infarct | | 1 4.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + | 70 | Depletion Lymphoid | | 1 4.0| Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 4| 7| 7| 2| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 2| 6| | | DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 8| 6| 4| 4| 4| 4| 3| 4| 4| 4| 4| 8| 4| | | | 2| 4| 2| 2| 4| 3| 3| 2| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 66 | Galactocele | X X | 2 | Lactation | 2 2 3 2 3 2 3 2 3 3 4 | 27 2.7| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 69 | Fibrosis | | 1 4.0| Hyperkeratosis | | 1 4.0| Perivascular, Inflammation, Chronic | | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperostosis | 2 4 | 12 2.8| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Ectopic Tissue | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 69 | Compression | 2 | 4 2.0| Hemorrhage | | 2 2.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis | | 2 1.5| Congestion | | 1 3.0| Emphysema, Focal | | 1 2.0| Hemorrhage, Focal | | 1 3.0| Alveolar Epithelium, Metaplasia | | 1 3.0| Peribronchial, Inflammation, Chronic | 2 | 9 1.8| Pleura, Fibrosis, Focal | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 69 | Fungus | 2 | 3 3.3| Inflammation, Acute | 3 2 | 5 2.2| Inflammation, Chronic, Focal | 2 2 | 9 2.0| Inflammation, Chronic | 2 4 2 3 2 | 16 2.3| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 4| 7| 7| 2| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 2| 6| | | DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 8| 6| 4| 4| 4| 4| 3| 4| 4| 4| 4| 8| 4| | | | 2| 4| 2| 2| 4| 3| 3| 2| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 68 | Cyst | X | 1 | Mineralization, Focal | 1 1 | 7 1.0| Mineralization | 2 2 1 2 | 20 1.8| Nephropathy | 3 2 2 1 2 2 1 2 1 2 2 | 39 1.7| Renal Tubule, Degeneration, Granular | | 1 4.0| Renal Tubule, Pigmentation, Bile | | 1 3.0| Renal Tubule, Regeneration | | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 67 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 2| 4| 4| 7| 2| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| DAY ON TEST | 6| 8| 6| 0| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 3| 3| 3| 3| 6| 6| 4| 3| 4| | 3| 2| 3| 4| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 3| 3| 7| 7| 7| 7| 4| 4| 1| 7| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | 2| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | 3 4 2 | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Parasite Metazoan | 2 2 3 3 3 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X | Fatty Change | 3 1 2 1 | Granuloma | 3 2 2 2 | Hepatodiaphragmatic Nodule | X X | Hepatodiaphragmatic Nodule, Multiple | | Mineralization, Focal | | Necrosis, Focal | | Bile Duct, Hyperplasia | 1 | __________________________________________________________________________| Mesentery | + | Accessory Spleen | | Fat, Necrosis | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | | Acinus, Atrophy | 2 2 2 3 3| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Diverticulum | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | | Edema, Focal | | Erosion | 4 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 2 2 2 2 3 2 4| Dilatation | | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 2| 4| 4| 7| 2| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| DAY ON TEST | 6| 8| 6| 0| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 3| 3| 3| 3| 6| 6| 4| 3| 4| | 3| 2| 3| 4| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 3| 3| 7| 7| 7| 7| 4| 4| 1| 7| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Inflammation, Chronic, Focal | 1 | Mineralization | | Myocardium, Inflammation, Chronic, | | Focal | 1 | Perivascular, Inflammation | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Cytoplasmic Alteration, Focal | 2 | Mineralization, Focal | | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 2 | Necrosis | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypoplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + M + + M M M + + + + + + + + M + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Pars Distalis, Angiectasis | 2 | Pars Distalis, Cyst | X X X | Pars Distalis, Hyperplasia, Focal | 3 1 3 3 2 2 | Pars Distalis, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | | C-Cell, Hyperplasia | 3 2 1 2 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X | Dilatation | 3 3 3 2 | Inflammation, Acute | 3 2 | Inflammation, Chronic, Focal | 2 3 | Inflammation, Chronic | 1 2 2 2 2 1 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Atrophy | | Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Atrophy | 2 | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 2| 4| 4| 7| 2| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| DAY ON TEST | 6| 8| 6| 0| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 3| 3| 3| 3| 6| 6| 4| 3| 4| | 3| 2| 3| 4| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 3| 3| 7| 7| 7| 7| 4| 4| 1| 7| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Cyst | X | Dilatation | 3 3 | Endometrium, Cyst | | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | Bacterium | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1| Myelofibrosis | | __________________________________________________________________________| Lymph Node | + | Inguinal, Congestion | | Lumbar, Congestion | | Mediastinal, Congestion | | Pancreatic, Angiectasis | | Pancreatic, Giant Cell | 3 | Pancreatic, Infiltration Cellular, | | Histiocyte | | Pancreatic, Pigmentation, Hemosiderin| 2 | Pancreatic, Lymphatic, Angiectasis | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Infiltration Cellular, Plasma Cell | 3 | Infiltration Cellular, Histiocyte | | Lymphatic, Angiectasis | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Depletion Lymphoid | | Giant Cell | 2 1 | Granuloma | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 2 | Fibrosis, Focal | | Hematopoietic Cell Proliferation | 2 4 | Capsule, Fibrosis | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| Cyst | X X X | Depletion Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | | Lactation | 3 2 4 2 3 2 3 4 2 | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 2| 4| 4| 7| 2| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| DAY ON TEST | 6| 8| 6| 0| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 3| 3| 3| 3| 6| 6| 4| 3| 4| | 3| 2| 3| 4| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 3| 3| 7| 7| 7| 7| 4| 4| 1| 7| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 4 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Compression | 4 | Hemorrhage | 2 | Capillary, Inflammation, Chronic | 2 | Choroid Plexus, Inflammation, Chronic| 2 | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | | Alveolar Epithelium, Metaplasia | | Peribronchial, Inflammation, Chronic | 2 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | 4 | Inflammation, Acute | 3 2 3 | Inflammation, Chronic, Focal | 3 2 | Inflammation, Chronic | 1 1 2 2 3 3 2 2 2 | Metaplasia, Squamous | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cataract | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Bacterium | | Cyst | | Glomerulosclerosis | | Mineralization | 1 1 1 1 2 2 1 | Nephropathy | 1 2 1 2 1 2 1 1 1 1 1 1 2 4 | Pigmentation | | Renal Tubule, Pigmentation, Bile | | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 2| 4| 4| 7| 2| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| DAY ON TEST | 6| 8| 6| 0| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 3| 3| 3| 3| 6| 6| 4| 3| 4| | 3| 2| 3| 4| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 3| 3| 7| 7| 7| 7| 4| 4| 1| 7| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic, Focal | 2 | _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 4| 2| 5| 2| 7| 6| 2| 7| 7| 2| 7| 2| 2| 4| 7| 5| 2| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 6| 6| 8| 9| 8| 4| 5| 8| 4| 4| 8| 4| 8| 8| 6| 3| 5| 8| 4| | 1| 1| 1| 1| 1| 2| 3| 3| 1| 1| 2| 2| 8| 2| 2| 2| 1| 1| 2| 2| 4| 8| 9| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | 4 X 4 | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | Parasite Metazoan | 3 3 X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 4 | Basophilic Focus | X X X X X X X X X X X X X X| Clear Cell Focus | X X X X| Fatty Change | 1 1 | Granuloma | 3 1 2| Hepatodiaphragmatic Nodule | X X | Hepatodiaphragmatic Nodule, Multiple | | Mineralization, Focal | | Necrosis, Focal | | Bile Duct, Hyperplasia | | __________________________________________________________________________| Mesentery | + | Accessory Spleen | | Fat, Necrosis | 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | 2 2 | Acinus, Atrophy | 3 3 2 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Diverticulum | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | 2| Edema, Focal | | Erosion | 4 | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 3 2 2 1 1 3 2 2| Dilatation | 2 | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 4| 2| 5| 2| 7| 6| 2| 7| 7| 2| 7| 2| 2| 4| 7| 5| 2| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 6| 6| 8| 9| 8| 4| 5| 8| 4| 4| 8| 4| 8| 8| 6| 3| 5| 8| 4| | 1| 1| 1| 1| 1| 2| 3| 3| 1| 1| 2| 2| 8| 2| 2| 2| 1| 1| 2| 2| 4| 8| 9| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Inflammation, Chronic, Focal | 1 1 1 | Mineralization | | Myocardium, Inflammation, Chronic, | | Focal | | Perivascular, Inflammation | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Cytoplasmic Alteration, Focal | 2 | Mineralization, Focal | | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Necrosis | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypoplasia | 1 1 1 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| Pars Distalis, Angiectasis | 4 | Pars Distalis, Cyst | X X X X X | Pars Distalis, Hyperplasia, Focal | 2 1 | Pars Distalis, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | 1 | C-Cell, Hyperplasia | 1 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Dilatation | 3 3 2 3 | Inflammation, Acute | | Inflammation, Chronic, Focal | 2 2 2 2 1 | Inflammation, Chronic | 2 2 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Atrophy | 3 | Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Atrophy | 3 | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 4| 2| 5| 2| 7| 6| 2| 7| 7| 2| 7| 2| 2| 4| 7| 5| 2| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 6| 6| 8| 9| 8| 4| 5| 8| 4| 4| 8| 4| 8| 8| 6| 3| 5| 8| 4| | 1| 1| 1| 1| 1| 2| 3| 3| 1| 1| 2| 2| 8| 2| 2| 2| 1| 1| 2| 2| 4| 8| 9| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Cyst | X | Dilatation | 3 3 3 4 | Endometrium, Cyst | | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | Bacterium | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 3 3 | Myelofibrosis | 2 | __________________________________________________________________________| Lymph Node | + + + + + | Inguinal, Congestion | 4 | Lumbar, Congestion | 3 | Mediastinal, Congestion | 4 | Pancreatic, Angiectasis | 4 | Pancreatic, Giant Cell | 4 | Pancreatic, Infiltration Cellular, | | Histiocyte | 3 | Pancreatic, Pigmentation, Hemosiderin| 2 | Pancreatic, Lymphatic, Angiectasis | 3 4 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +| Congestion | 2 2 3 | Infiltration Cellular, Plasma Cell | | Infiltration Cellular, Histiocyte | | Lymphatic, Angiectasis | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 4 3 | Depletion Lymphoid | | Giant Cell | 2 2 2 3 2 1 2 | Granuloma | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 3 1 3 2 2| Fibrosis, Focal | 3 | Hematopoietic Cell Proliferation | | Capsule, Fibrosis | | __________________________________________________________________________| Thymus | + + + + M + I + + + + + + + + + + + + + + M + + +| Cyst | | Depletion Lymphoid | 4 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | X | Lactation | 2 2 2 3 3 3 2 | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 4| 2| 5| 2| 7| 6| 2| 7| 7| 2| 7| 2| 2| 4| 7| 5| 2| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 6| 6| 8| 9| 8| 4| 5| 8| 4| 4| 8| 4| 8| 8| 6| 3| 5| 8| 4| | 1| 1| 1| 1| 1| 2| 3| 3| 1| 1| 2| 2| 8| 2| 2| 2| 1| 1| 2| 2| 4| 8| 9| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 4 2 4| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Compression | 4 2 3 | Hemorrhage | 2 4 | Capillary, Inflammation, Chronic | | Choroid Plexus, Inflammation, Chronic| | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | | Alveolar Epithelium, Metaplasia | | Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | 3 4 | Inflammation, Acute | 2 3 2 2 | Inflammation, Chronic, Focal | 2 2 2 2 2 | Inflammation, Chronic | 2 2 2 | Metaplasia, Squamous | 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cataract | | __________________________________________________________________________| Harderian Gland | +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Bacterium | | Cyst | X | Glomerulosclerosis | 4 | Mineralization | 1 1 2 | Nephropathy | 1 2 1 2 1 1 2 2 2 2 1 1 2 2| Pigmentation | 3 | Renal Tubule, Pigmentation, Bile | 3 | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 4| 2| 5| 2| 7| 6| 2| 7| 7| 2| 7| 2| 2| 4| 7| 5| 2| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 6| 6| 8| 9| 8| 4| 5| 8| 4| 4| 8| 4| 8| 8| 6| 3| 5| 8| 4| | 1| 1| 1| 1| 1| 2| 3| 3| 1| 1| 2| 2| 8| 2| 2| 2| 1| 1| 2| 2| 4| 8| 9| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Renal Tubule, Regeneration | 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | Inflammation, Chronic, Focal | | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 2| 6| 7| 7| 7| | | DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 3| 4| 1| 3| 4| 4| 7| 4| 8| 6| 4| 4| 4| | | | 1| 4| 9| 2| 2| 1| 2| 0| 1| 4| 7| 1| 1| 6| 1| 1| 9| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + M + + + + + + + + + + + + + + | 69 | Angiectasis | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + | 69 | Parasite Metazoan | 2 3 | 4 2.3| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 | Parasite Metazoan | | 6 3.4| __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + A + + + + + + + + + + | 68 | Inflammation, Chronic | | 1 2.0| Parasite Metazoan | | 8 2.7| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + + + A + + + + + + + + + + | 68 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + + + A + + + + + + + + + + | 68 | Abscess | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis | | 4 2.5| Basophilic Focus | X X X X X X X X X X X X X | 48 | Clear Cell Focus | X X | 10 | Fatty Change | 1 | 7 1.4| Granuloma | 2 | 8 2.1| Hepatodiaphragmatic Nodule | X X | 6 | Hepatodiaphragmatic Nodule, Multiple | X | 1 | Mineralization, Focal | 3 | 1 3.0| Necrosis, Focal | 2 | 1 2.0| Bile Duct, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Mesentery | + | 3 | Accessory Spleen | X | 1 | Fat, Necrosis | | 2 3.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 | Inflammation, Chronic, Focal | | 2 2.0| Acinus, Atrophy | 2 4 2 4 | 13 2.7| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 | Acanthosis | 3 | 1 3.0| Diverticulum | | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 | Depletion Cellular | | 1 2.0| Edema, Focal | 2 | 1 2.0| Erosion | 2 4 4 | 5 3.6| __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 2| 6| 7| 7| 7| | | DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 3| 4| 1| 3| 4| 4| 7| 4| 8| 6| 4| 4| 4| | | | 1| 4| 9| 2| 2| 1| 2| 0| 1| 4| 7| 1| 1| 6| 1| 1| 9| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | Cardiomyopathy | 2 3 2 3 4 2 2 2 | 26 2.2| Dilatation | | 1 2.0| Inflammation, Chronic, Focal | | 4 1.0| Mineralization | 1 | 1 1.0| Myocardium, Inflammation, Chronic, | | | Focal | | 1 1.0| Perivascular, Inflammation | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 69 | Atrophy | | 1 2.0| Cytoplasmic Alteration, Focal | 2 | 3 2.0| Mineralization, Focal | 3 | 1 3.0| Vacuolization Cytoplasmic | 2 3 | 2 2.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperplasia, Focal | | 2 2.5| Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 | Hypoplasia | | 4 1.3| __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + + + + + + + M + + + + | 61 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + M + + + + + + + + + + + | 67 | Pars Distalis, Angiectasis | | 2 3.0| Pars Distalis, Cyst | | 8 | Pars Distalis, Hyperplasia, Focal | 2 3 3 | 11 2.3| Pars Distalis, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 | Inflammation, Chronic, Focal | | 1 1.0| C-Cell, Hyperplasia | 1 1 1 | 12 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + M + + + + + + + + + + + + + + + + + | 69 | Cyst | | 3 | Dilatation | 3 | 9 2.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 2| 6| 7| 7| 7| | | DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 3| 4| 1| 3| 4| 4| 7| 4| 8| 6| 4| 4| 4| | | | 1| 4| 9| 2| 2| 1| 2| 0| 1| 4| 7| 1| 1| 6| 1| 1| 9| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Acute | | 2 2.5| Inflammation, Chronic, Focal | 2 | 8 2.0| Inflammation, Chronic | 2 | 11 1.8| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis | | 1 3.0| Atrophy | | 1 3.0| Cyst | X X | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis | | 1 3.0| Atrophy | | 2 2.5| Cyst | | 2 | Dilatation | | 6 3.2| Endometrium, Cyst | X | 1 | __________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + | 1 | Bacterium | X | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperplasia | 3 2 4 3 3 | 12 2.5| Myelofibrosis | 4 | 2 3.0| __________________________________________________________________________|____________| Lymph Node | + + | 8 | Inguinal, Congestion | | 1 4.0| Lumbar, Congestion | | 1 3.0| Mediastinal, Congestion | | 1 4.0| Pancreatic, Angiectasis | | 1 4.0| Pancreatic, Giant Cell | | 2 3.5| Pancreatic, Infiltration Cellular, | | | Histiocyte | | 1 3.0| Pancreatic, Pigmentation, Hemosiderin| | 2 2.0| Pancreatic, Lymphatic, Angiectasis | | 2 3.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 69 | Congestion | | 3 2.3| Infiltration Cellular, Plasma Cell | | 1 3.0| Infiltration Cellular, Histiocyte | 4 | 1 4.0| Lymphatic, Angiectasis | | 2 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 70 | Congestion | 3 4 | 4 3.5| Depletion Lymphoid | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 2| 6| 7| 7| 7| | | DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 3| 4| 1| 3| 4| 4| 7| 4| 8| 6| 4| 4| 4| | | | 1| 4| 9| 2| 2| 1| 2| 0| 1| 4| 7| 1| 1| 6| 1| 1| 9| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Giant Cell | 1 | 10 1.8| Granuloma | 4 | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 70 | Depletion Lymphoid | 1 2 | 9 2.0| Fibrosis, Focal | | 1 3.0| Hematopoietic Cell Proliferation | 3 | 3 3.0| Capsule, Fibrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + + + + + + + + + | 65 | Cyst | | 3 | Depletion Lymphoid | | 1 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 70 | Galactocele | | 1 | Lactation | 2 2 3 2 3 2 2 2 2 | 25 2.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperostosis | 3 3 3 | 8 3.3| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | Abscess | 2 | 1 2.0| Compression | | 4 3.3| Hemorrhage | 4 | 4 3.0| Capillary, Inflammation, Chronic | 2 | 2 2.0| Choroid Plexus, Inflammation, Chronic| | 1 2.0| __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Mineralization, Focal | 4 | 1 4.0| Alveolar Epithelium, Metaplasia | 4 | 1 4.0| Peribronchial, Inflammation, Chronic | 2 | 10 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | Fungus | | 3 3.7| Inflammation, Acute | 2 3 2 | 10 2.4| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 2| 6| 7| 7| 7| | | DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 3| 4| 1| 3| 4| 4| 7| 4| 8| 6| 4| 4| 4| | | | 1| 4| 9| 2| 2| 1| 2| 0| 1| 4| 7| 1| 1| 6| 1| 1| 9| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Chronic, Focal | 2 | 8 2.1| Inflammation, Chronic | 3 3 | 14 2.1| Metaplasia, Squamous | | 1 3.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 2 | Cataract | 2 | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + A + + + + + + + + + + + + + + + + + | 69 | Abscess | 3 | 1 3.0| Bacterium | X | 1 | Cyst | | 1 | Glomerulosclerosis | | 1 4.0| Mineralization | 2 1 1 2 1 1 1 1 2 1 | 20 1.3| Nephropathy | 1 1 2 2 1 1 1 1 1 1 1 2 | 40 1.5| Pigmentation | | 1 3.0| Renal Tubule, Pigmentation, Bile | 2 | 2 2.5| Renal Tubule, Regeneration | | 2 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + A + + + + + + + + + + + + + + + + + | 68 | Hemorrhage | 4 | 2 4.0| Inflammation, Chronic, Focal | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 6| 6| 4| 7| 5| 4| 7| 2| 7| 6| 7| 5| 7| 7| 7| 4| 2| 2| 2| 3| 4| 6| 7| 7| DAY ON TEST | 5| 3| 3| 6| 3| 2| 6| 3| 7| 3| 9| 1| 6| 1| 3| 3| 6| 7| 7| 7| 0| 6| 3| 3| 3| | 9| 2| 2| 3| 6| 4| 2| 6| 6| 6| 5| 5| 6| 7| 6| 6| 2| 6| 6| 5| 4| 3| 9| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +| Parasite Metazoan | 2 X 4 4 X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| Parasite Metazoan | 2 3 X 4 X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +| Edema | 4 | Parasite Metazoan | 2 X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + A + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 3 4 | Basophilic Focus | X X X X X X X X X X X X X X| Clear Cell Focus | X X | Cyst | | Developmental Malformation | X| Eosinophilic Focus | | Fatty Change | 2 2 4 | Fibrosis, Focal | 3 | Hepatodiaphragmatic Nodule | | Necrosis, Focal | 2 | Proliferation | 3 | Bile Duct, Hyperplasia | 2 3 4 2 4| Lymphatic, Angiectasis, Focal | | __________________________________________________________________________| Mesentery | + + + | Accessory Spleen | | Fat, Hemorrhage | 4 | Fat, Necrosis | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 3 3 2 4 2 1 3| Acinus, Hyperplasia, Focal | | Vein, Thrombosis | | __________________________________________________________________________| Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +| Atrophy | 2 | Thrombosis | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 3| Ulcer | 2 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 4 1 | Hyperplasia, Lymphoid | | Mucosa, Inflammation, Acute | 3 | _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 6| 6| 4| 7| 5| 4| 7| 2| 7| 6| 7| 5| 7| 7| 7| 4| 2| 2| 2| 3| 4| 6| 7| 7| DAY ON TEST | 5| 3| 3| 6| 3| 2| 6| 3| 7| 3| 9| 1| 6| 1| 3| 3| 6| 7| 7| 7| 0| 6| 3| 3| 3| | 9| 2| 2| 3| 6| 4| 2| 6| 6| 6| 5| 5| 6| 7| 6| 6| 2| 6| 6| 5| 4| 3| 9| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 3 2 1 2 4 4 1 2 2 2 3 2 4 2 2 3 2 3| Inflammation, Chronic, Focal | 1 2 | Mineralization | 2 | Artery, Inflammation, Chronic | | Atrium, Dilatation | 4 | Atrium, Thrombosis | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | | Cytoplasmic Alteration | 2 | Hypertrophy | 3 | Vacuolization Cytoplasmic | 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | Hyperplasia, Focal | 1 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Thymus | | Hyperplasia, Focal | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia, Focal | 3 3 2 | Pars Intermedia, Cyst | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 4 3 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | 2| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Cyst | X | Ectasia | | Hyperplasia | | Inflammation, Chronic, Focal | 2 2 2 | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 6| 6| 4| 7| 5| 4| 7| 2| 7| 6| 7| 5| 7| 7| 7| 4| 2| 2| 2| 3| 4| 6| 7| 7| DAY ON TEST | 5| 3| 3| 6| 3| 2| 6| 3| 7| 3| 9| 1| 6| 1| 3| 3| 6| 7| 7| 7| 0| 6| 3| 3| 3| | 9| 2| 2| 3| 6| 4| 2| 6| 6| 6| 5| 5| 6| 7| 6| 6| 2| 6| 6| 5| 4| 3| 9| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic | 1 1 2 3 2 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 3 3 3 3 2 2 | Dilatation | | Inflammation, Acute | 3 | Inflammation, Chronic | 4 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 3 3 4 4 4 4 4 3 4 4 4| Dilatation | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, | | Hyperplasia | 3 3 | Interstitial Cell, Hyperplasia | 3 | Seminiferous Tubule, Atrophy | 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 4 4 3 3 4 4 4| Myelofibrosis | 4 | __________________________________________________________________________| Lymph Node | + + + + + | Mediastinal, Congestion | 3 | Mediastinal, Lymphatic, Angiectasis | 3 | Pancreatic, Lymphatic, Angiectasis | 4 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +| Angiectasis | 3 | Congestion | | Infiltration Cellular, Plasma Cell | 4 | Lymphatic, Angiectasis | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 | Congestion | | Depletion Lymphoid | 3 | Giant Cell | 2 2 | Lymphatic, Angiectasis | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 4 | Depletion Lymphoid | 4 2 2 | Fibrosis | 4 4 2 3| Hematopoietic Cell Proliferation | 4 4 3 | Hypertrophy | 3 | Infarct | | Necrosis, Focal | | Thrombosis | X | Capsule, Congestion, Focal | | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 6| 6| 4| 7| 5| 4| 7| 2| 7| 6| 7| 5| 7| 7| 7| 4| 2| 2| 2| 3| 4| 6| 7| 7| DAY ON TEST | 5| 3| 3| 6| 3| 2| 6| 3| 7| 3| 9| 1| 6| 1| 3| 3| 6| 7| 7| 7| 0| 6| 3| 3| 3| | 9| 2| 2| 3| 6| 4| 2| 6| 6| 6| 5| 5| 6| 7| 6| 6| 2| 6| 6| 5| 4| 3| 9| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Capsule, Fibrosis | | __________________________________________________________________________| Thymus | M + + + + M + M + + + M + + + M + + + + + + M + +| Depletion Lymphoid | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + + + + + + + M + + + + + + + + + + M| Lactation | 1 4 2 4 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Fibrosis, Focal | | Ulcer | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Callus | | Hyperostosis | 2 2 | Proliferation | 3 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 4 | Hemorrhage | | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | Hemorrhage, Focal | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 3 | Hemorrhage, Focal | | Hyperplasia, Adenomatous | | Infiltration Cellular, Focal, | | Histiocyte | 3 4 | Peribronchial, Inflammation, Chronic | 1 1 3 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | 3 4 4 4 | Hyperkeratosis | 4 | Hyperplasia, Basal Cell | 3 | Inflammation, Acute | 4 | Inflammation, Chronic, Focal | 2 2 2 2 | Inflammation, Chronic | 2 2 3 1 | Metaplasia, Squamous | 2 2 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 4| 6| 6| 4| 7| 5| 4| 7| 2| 7| 6| 7| 5| 7| 7| 7| 4| 2| 2| 2| 3| 4| 6| 7| 7| DAY ON TEST | 5| 3| 3| 6| 3| 2| 6| 3| 7| 3| 9| 1| 6| 1| 3| 3| 6| 7| 7| 7| 0| 6| 3| 3| 3| | 9| 2| 2| 3| 6| 4| 2| 6| 6| 6| 5| 5| 6| 7| 6| 6| 2| 6| 6| 5| 4| 3| 9| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + + | __________________________________________________________________________| Eye | | Retina, Degeneration | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 | Mineralization | 4 | Necrosis, Focal | | Nephropathy | 1 1 1 4 1 1 4 4 2 3 4 3 4 2 1 1 3 2| Papilla, Necrosis | 4 | Renal Tubule, Degeneration, Granular | 3 | Renal Tubule, Pigmentation, Bile | 2 4| Renal Tubule, Regeneration | 1 1 | __________________________________________________________________________| Ureter | + | Hyperplasia | 4 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +| Calculus Micro Observation Only | X X | Ulcer | 4 | Transitional Epithelium, Hyperplasia | 4 | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 7| 2| 4| 7| 4| 7| 2| 3| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 2| 6| 2| 7| DAY ON TEST | 9| 3| 7| 6| 3| 6| 3| 7| 9| 6| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 0| 7| 6| 7| 3| | 8| 5| 6| 3| 5| 3| 5| 5| 1| 2| 5| 5| 5| 5| 9| 5| 3| 6| 6| 6| 1| 6| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| Parasite Metazoan | 2 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +| Edema | 3 | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | | Basophilic Focus | X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X | Cyst | X | Developmental Malformation | X X | Eosinophilic Focus | | Fatty Change | 1 2 | Fibrosis, Focal | | Hepatodiaphragmatic Nodule | X X | Necrosis, Focal | 3| Proliferation | | Bile Duct, Hyperplasia | 2 2 3 3 4 4 3 | Lymphatic, Angiectasis, Focal | 4 | __________________________________________________________________________| Mesentery | + | Accessory Spleen | X | Fat, Hemorrhage | | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +| Acinus, Atrophy | 4 2 4 2 3 3 2 4 2 | Acinus, Hyperplasia, Focal | 2 | Vein, Thrombosis | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Thrombosis | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Ulcer | 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +| Erosion | 2 1 2 | Hyperplasia, Lymphoid | 3 2 2 3 | Mucosa, Inflammation, Acute | | _____________________________________________________________________________________________________________________| Page 61 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 7| 2| 4| 7| 4| 7| 2| 3| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 2| 6| 2| 7| DAY ON TEST | 9| 3| 7| 6| 3| 6| 3| 7| 9| 6| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 0| 7| 6| 7| 3| | 8| 5| 6| 3| 5| 3| 5| 5| 1| 2| 5| 5| 5| 5| 9| 5| 3| 6| 6| 6| 1| 6| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 3 3 2 2 2 1 4 2 1 2 4 3 4 2 4 4 2 2 2 1| Inflammation, Chronic, Focal | | Mineralization | 1 1 1 | Artery, Inflammation, Chronic | | Atrium, Dilatation | | Atrium, Thrombosis | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | | Cytoplasmic Alteration | | Hypertrophy | | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Focal | 1 1 1 3| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + + I + + + + + M + +| Ectopic Thymus | | Hyperplasia, Focal | 3 2| __________________________________________________________________________| Pituitary Gland | + + + + + + + + A + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2| Pars Distalis, Cyst | X| Pars Distalis, Hyperplasia, Focal | 2 2 2 2 | Pars Intermedia, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | 3 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 2 1 2 3 | Cyst | X X | Ectasia | 3 4 | Hyperplasia | | Inflammation, Chronic, Focal | 3 2 2 | _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 7| 2| 4| 7| 4| 7| 2| 3| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 2| 6| 2| 7| DAY ON TEST | 9| 3| 7| 6| 3| 6| 3| 7| 9| 6| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 0| 7| 6| 7| 3| | 8| 5| 6| 3| 5| 3| 5| 5| 1| 2| 5| 5| 5| 5| 9| 5| 3| 6| 6| 6| 1| 6| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic | 2 2 2 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 2 3 3 3 2 3 | Dilatation | | Inflammation, Acute | | Inflammation, Chronic | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 4 3 4 3 4 3 4 4 4 3 4 4 | Dilatation | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, | | Hyperplasia | 3 3 | Interstitial Cell, Hyperplasia | | Seminiferous Tubule, Atrophy | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 4 3 4| Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + | Mediastinal, Congestion | | Mediastinal, Lymphatic, Angiectasis | 3 3 3 | Pancreatic, Lymphatic, Angiectasis | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +| Angiectasis | 4 4 3 | Congestion | | Infiltration Cellular, Plasma Cell | 4 | Lymphatic, Angiectasis | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 3 4 | Congestion | | Depletion Lymphoid | | Giant Cell | 2 2 1 1 | Lymphatic, Angiectasis | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Depletion Lymphoid | | Fibrosis | 2 4 2 2 2 | Hematopoietic Cell Proliferation | | Hypertrophy | | Infarct | 2 | Necrosis, Focal | 3 | Thrombosis | | Capsule, Congestion, Focal | 3 | _____________________________________________________________________________________________________________________| Page 63 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 7| 2| 4| 7| 4| 7| 2| 3| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 2| 6| 2| 7| DAY ON TEST | 9| 3| 7| 6| 3| 6| 3| 7| 9| 6| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 0| 7| 6| 7| 3| | 8| 5| 6| 3| 5| 3| 5| 5| 1| 2| 5| 5| 5| 5| 9| 5| 3| 6| 6| 6| 1| 6| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Capsule, Fibrosis | 3 3 | __________________________________________________________________________| Thymus | + + + M + M + + + + + + + + + + + M + + + + + + +| Depletion Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + + + + + + + M M + M + + + M + + + + + +| Lactation | 3 4 2 2 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | Fibrosis, Focal | | Ulcer | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Callus | 4 | Hyperostosis | 3 | Proliferation | | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 4 | Hemorrhage | | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | Hemorrhage, Focal | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hemorrhage, Focal | | Hyperplasia, Adenomatous | 2 | Infiltration Cellular, Focal, | | Histiocyte | 3 3| Peribronchial, Inflammation, Chronic | 2 2 2 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | 4 4 3 4 4 4 2 4 4 4 4 | Hyperkeratosis | | Hyperplasia, Basal Cell | 4 | Inflammation, Acute | 2 2 3 | Inflammation, Chronic, Focal | 2 2 2 2 | Inflammation, Chronic | 2 2 2 4 | Metaplasia, Squamous | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 64 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 7| 2| 4| 7| 4| 7| 2| 3| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 2| 6| 2| 7| DAY ON TEST | 9| 3| 7| 6| 3| 6| 3| 7| 9| 6| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 0| 7| 6| 7| 3| | 8| 5| 6| 3| 5| 3| 5| 5| 1| 2| 5| 5| 5| 5| 9| 5| 3| 6| 6| 6| 1| 6| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + | Retina, Degeneration | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| Abscess | | Mineralization | | Necrosis, Focal | 3 | Nephropathy | 3 4 1 4 1 4 1 4 2 2 3 1 3 3 1 1 1 1| Papilla, Necrosis | | Renal Tubule, Degeneration, Granular | 2| Renal Tubule, Pigmentation, Bile | | Renal Tubule, Regeneration | 2 1 1 | __________________________________________________________________________| Ureter | | Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + A + + + + + + + + + + + A + A + +| Calculus Micro Observation Only | X X | Ulcer | | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 4| 2| 7| 5| 5| 7| 6| 4| 7| 7| 7| 7| 2| 6| 6| 7| 7| 6| 6| 7| | | DAY ON TEST | 6| 7| 3| 9| 5| 3| 7| 6| 3| 3| 3| 3| 7| 7| 1| 3| 3| 3| 7| 3| | | | 2| 5| 5| 4| 0| 5| 2| 2| 5| 5| 6| 6| 5| 7| 2| 6| 6| 5| 7| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + + + + + + A + + + + + | 66 | Parasite Metazoan | 4 | 8 3.2| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + | 68 | Parasite Metazoan | 4 2 X | 10 3.0| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + + + + + + A + + + + + | 66 | Edema | | 2 3.5| Parasite Metazoan | | 3 2.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + | 66 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + + + + A + + + + + | 65 | Hyperplasia, Lymphoid | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + + + + A + + + + + | 66 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis, Focal | | 2 3.5| Basophilic Focus | X X X X X X X X X | 39 | Clear Cell Focus | X X X X | 10 | Cyst | X | 2 | Developmental Malformation | | 3 | Eosinophilic Focus | X X | 2 | Fatty Change | 2 3 2 3 | 9 2.3| Fibrosis, Focal | | 1 3.0| Hepatodiaphragmatic Nodule | X | 3 | Necrosis, Focal | 3 | 3 2.7| Proliferation | | 1 3.0| Bile Duct, Hyperplasia | 2 4 4 3 1 3 3 3 3 3 3 3 | 24 3.0| Lymphatic, Angiectasis, Focal | 3 | 2 3.5| __________________________________________________________________________|____________| Mesentery | + + | 6 | Accessory Spleen | | 1 | Fat, Hemorrhage | | 1 4.0| Fat, Necrosis | 4 4 | 3 3.7| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 | Acinus, Atrophy | 2 3 2 4 2 | 21 2.7| Acinus, Hyperplasia, Focal | 2 | 2 2.0| Vein, Thrombosis | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 69 | Atrophy | | 1 2.0| Thrombosis | X | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + | 69 | Hyperkeratosis | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 66 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 4| 2| 7| 5| 5| 7| 6| 4| 7| 7| 7| 7| 2| 6| 6| 7| 7| 6| 6| 7| | | DAY ON TEST | 6| 7| 3| 9| 5| 3| 7| 6| 3| 3| 3| 3| 7| 7| 1| 3| 3| 3| 7| 3| | | | 2| 5| 5| 4| 0| 5| 2| 2| 5| 5| 6| 6| 5| 7| 2| 6| 6| 5| 7| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Ulcer | | 3 3.3| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + | 68 | Erosion | 4 3 1 | 8 2.3| Hyperplasia, Lymphoid | | 4 2.5| Mucosa, Inflammation, Acute | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | Cardiomyopathy | 1 2 4 4 1 4 1 1 2 3 2 2 4 3 2 1 2 | 56 2.4| Inflammation, Chronic, Focal | | 2 1.5| Mineralization | | 4 1.3| Artery, Inflammation, Chronic | 2 | 1 2.0| Atrium, Dilatation | | 1 4.0| Atrium, Thrombosis | X X X | 6 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 | Cytoplasmic Alteration, Focal | 2 2 | 2 2.0| Cytoplasmic Alteration | | 1 2.0| Hypertrophy | | 1 3.0| Vacuolization Cytoplasmic | 4 3 | 3 3.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + M + + + + + + + + + + + + + | 69 | Hemorrhage | | 1 4.0| Hyperplasia, Focal | 2 3 3 2 2 3 1 1 1 3 | 16 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 | Hyperplasia | | 4 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 67 | Ectopic Thymus | X | 1 | Hyperplasia, Focal | | 2 2.5| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 68 | Pars Distalis, Angiectasis | | 1 2.0| Pars Distalis, Cyst | | 1 | Pars Distalis, Hyperplasia, Focal | 3 2 2 | 10 2.3| Pars Intermedia, Cyst | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 | C-Cell, Hyperplasia | 3 | 5 3.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 67 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 4| 2| 7| 5| 5| 7| 6| 4| 7| 7| 7| 7| 2| 6| 6| 7| 7| 6| 6| 7| | | DAY ON TEST | 6| 7| 3| 9| 5| 3| 7| 6| 3| 3| 3| 3| 7| 7| 1| 3| 3| 3| 7| 3| | | | 2| 5| 5| 4| 0| 5| 2| 2| 5| 5| 6| 6| 5| 7| 2| 6| 6| 5| 7| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 | Depletion Cellular | | 2 2.5| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 70 | Abscess | 3 3 3 | 7 2.4| Cyst | X | 4 | Ectasia | 4 3 4 | 5 3.6| Hyperplasia | 4 | 1 4.0| Inflammation, Chronic, Focal | 2 2 | 8 2.1| Inflammation, Chronic | 2 4 2 2 2 | 17 2.1| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + M + + | 69 | Atrophy | 4 3 2 | 18 2.7| Dilatation | 4 2 | 2 3.0| Inflammation, Acute | | 1 3.0| Inflammation, Chronic | | 1 4.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + A + + + + + + + + + + M + + | 68 | Atrophy | 4 4 3 3 2 3 3 4 4 2 4 | 36 3.5| Dilatation | 4 | 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 70 | Bilateral, Interstitial Cell, | | | Hyperplasia | | 4 3.0| Interstitial Cell, Hyperplasia | | 1 3.0| Seminiferous Tubule, Atrophy | 2 4 | 3 3.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + M + + + + + + + + + + + + + | 69 | Hyperplasia | 3 4 4 4 2 4 | 22 3.2| Myelofibrosis | | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + | 12 | Mediastinal, Congestion | | 1 3.0| Mediastinal, Lymphatic, Angiectasis | | 4 3.0| Pancreatic, Lymphatic, Angiectasis | | 2 3.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 68 | Angiectasis | | 4 3.5| Congestion | 3 | 1 3.0| Infiltration Cellular, Plasma Cell | | 2 4.0| Lymphatic, Angiectasis | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 69 | Angiectasis | 4 | 5 3.8| Congestion | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 68 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 4| 2| 7| 5| 5| 7| 6| 4| 7| 7| 7| 7| 2| 6| 6| 7| 7| 6| 6| 7| | | DAY ON TEST | 6| 7| 3| 9| 5| 3| 7| 6| 3| 3| 3| 3| 7| 7| 1| 3| 3| 3| 7| 3| | | | 2| 5| 5| 4| 0| 5| 2| 2| 5| 5| 6| 6| 5| 7| 2| 6| 6| 5| 7| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Depletion Lymphoid | | 1 3.0| Giant Cell | 1 2 | 8 1.6| Lymphatic, Angiectasis | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 70 | Congestion | | 1 4.0| Depletion Lymphoid | | 3 2.7| Fibrosis | 2 3 3 4 3 | 14 2.9| Hematopoietic Cell Proliferation | | 3 3.7| Hypertrophy | | 1 3.0| Infarct | 4 | 2 3.0| Necrosis, Focal | | 1 3.0| Thrombosis | | 1 | Capsule, Congestion, Focal | | 1 3.0| Capsule, Fibrosis | | 2 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + M + M + + + + + + + + + | 59 | Depletion Lymphoid | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + M M + + + M + + M + + + + + M + + | 57 | Lactation | 2 1 3 2 | 14 2.4| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 70 | Cyst Epithelial Inclusion | | 1 | Fibrosis, Focal | 4 4 | 2 4.0| Ulcer | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + M + + + + + + + + + + + + + | 69 | Callus | | 1 4.0| Hyperostosis | 2 2 | 5 2.2| Proliferation | | 1 3.0| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | Compression | | 2 4.0| Hemorrhage | 3 | 1 3.0| __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | Hemorrhage, Focal | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 69 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 4| 2| 7| 5| 5| 7| 6| 4| 7| 7| 7| 7| 2| 6| 6| 7| 7| 6| 6| 7| | | DAY ON TEST | 6| 7| 3| 9| 5| 3| 7| 6| 3| 3| 3| 3| 7| 7| 1| 3| 3| 3| 7| 3| | | | 2| 5| 5| 4| 0| 5| 2| 2| 5| 5| 6| 6| 5| 7| 2| 6| 6| 5| 7| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis | 2 | 3 2.7| Hemorrhage, Focal | 2 | 1 2.0| Hyperplasia, Adenomatous | | 1 2.0| Infiltration Cellular, Focal, | | | Histiocyte | 4 | 5 3.4| Peribronchial, Inflammation, Chronic | 2 3 2 | 11 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 70 | Fungus | 4 3 4 | 18 3.7| Hyperkeratosis | | 1 4.0| Hyperplasia, Basal Cell | | 2 3.5| Inflammation, Acute | | 4 2.8| Inflammation, Chronic, Focal | 2 2 | 10 2.0| Inflammation, Chronic | 3 3 | 10 2.4| Metaplasia, Squamous | | 4 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 3 | __________________________________________________________________________|____________| Eye | | 1 | Retina, Degeneration | | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 69 | Abscess | | 1 4.0| Mineralization | | 1 4.0| Necrosis, Focal | | 1 3.0| Nephropathy | 1 1 4 2 2 2 2 2 3 2 2 2 1 1 2 4 2 1 2 4 | 56 2.2| Papilla, Necrosis | | 1 4.0| Renal Tubule, Degeneration, Granular | | 2 2.5| Renal Tubule, Pigmentation, Bile | 3 | 3 3.0| Renal Tubule, Regeneration | | 5 1.2| __________________________________________________________________________|____________| Ureter | | 1 | Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + A + + + + + + + A + + M + + | 63 | Calculus Micro Observation Only | X | 5 | Ulcer | | 1 4.0| Transitional Epithelium, Hyperplasia | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 70 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 7| 7| 3| 4| 4| 7| 7| 7| 7| 4| 2| 7| 7| 4| 7| 7| 7| 7| 2| 7| 6| 4| 7| 6| DAY ON TEST | 7| 3| 3| 1| 6| 6| 3| 1| 3| 3| 6| 7| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 2| 3| 7| | 5| 4| 4| 5| 3| 2| 4| 7| 5| 4| 3| 5| 4| 4| 3| 4| 5| 4| 5| 6| 4| 9| 9| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 100 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | 2 2 4 2 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X 2 3 4 | __________________________________________________________________________| Intestine Large, Cecum | + + + A + + + A + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 4 | Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 2 3 3 2 2 | Atrophy | | Basophilic Focus | X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X | Cyst | X | Developmental Malformation | X | Eosinophilic Focus | | Fatty Change | 1 1 2 2| Granuloma | | Hepatodiaphragmatic Nodule | X | Infarct | | Necrosis, Focal | 2 | Thrombosis | | Bile Duct, Dilatation | 4 | Bile Duct, Hyperplasia | 3 2 1 2 3 3 1 4 | Lymphatic, Angiectasis, Focal | | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4| Acinus, Atrophy | 2 1 1 2 2 2 3 3 1 1 | Acinus, Hyperplasia, Focal | 3 | Artery, Inflammation, Chronic | | __________________________________________________________________________| Pharynx | + | Palate, Inflammation, Chronic | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 3 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | | Ulcer | | _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 7| 7| 3| 4| 4| 7| 7| 7| 7| 4| 2| 7| 7| 4| 7| 7| 7| 7| 2| 7| 6| 4| 7| 6| DAY ON TEST | 7| 3| 3| 1| 6| 6| 3| 1| 3| 3| 6| 7| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 2| 3| 7| | 5| 4| 4| 5| 3| 2| 4| 7| 5| 4| 3| 5| 4| 4| 3| 4| 5| 4| 5| 6| 4| 9| 9| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 100 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 4| Hyperplasia, Lymphoid | 2 3 | Submucosa, Fibrosis | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 3 1 1 4 2 2 2 1 3 2 3 3 2 1 4 3 2 1 1| Inflammation, Chronic, Focal | 1 | Artery, Inflammation, Chronic | 2 | Atrium, Dilatation | 4 | Ventricle, Dilatation | 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | 2 | Hyperplasia, Focal | | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4| Hyperplasia, Focal | 3 3 2 1 1 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + I + + + + + + + + + + + + + + M + + + M + +| Hyperplasia, Focal | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| Pars Distalis, Angiectasis | | Pars Distalis, Cyst | X | Pars Distalis, Hemorrhage | | Pars Distalis, Hyperplasia, Focal | 2 1 2 2 2 4 3 | Pars Distalis, Inflammation, Chronic,| | Focal | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| Ultimobranchial Cyst | X | C-Cell, Hyperplasia | 3 1 2 | Follicle, Cyst | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | 3 | __________________________________________________________________________| Preputial Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Abscess | 2 2 3 | _____________________________________________________________________________________________________________________| Page 72 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 7| 7| 3| 4| 4| 7| 7| 7| 7| 4| 2| 7| 7| 4| 7| 7| 7| 7| 2| 7| 6| 4| 7| 6| DAY ON TEST | 7| 3| 3| 1| 6| 6| 3| 1| 3| 3| 6| 7| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 2| 3| 7| | 5| 4| 4| 5| 3| 2| 4| 7| 5| 4| 3| 5| 4| 4| 3| 4| 5| 4| 5| 6| 4| 9| 9| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 100 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Cyst | X | Ectasia | | Inflammation, Acute | 2 3 | Inflammation, Chronic, Focal | 2 1 2 | Inflammation, Chronic | 2 2 2 3 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 2 2 2 2 | Dilatation | 2 | Inflammation, Focal | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 3 4 4 4 4 3 3 3 4 4 4 4 4 2| Dilatation | 3 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | | Bilateral, Interstitial Cell, | | Hyperplasia | 2 | Interstitial Cell, Hyperplasia | 2 | Seminiferous Tubule, Atrophy | 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 4 2 1 1 4 4| __________________________________________________________________________| Lymph Node | + + + + + +| Inguinal, Lymphatic, Angiectasis | | Mediastinal, Congestion | | Mediastinal, Granuloma | 4 | Mediastinal, Pigmentation | | Mediastinal, Lymphatic, Angiectasis | 3 | Pancreatic, Hyperplasia, Lymphoid | 3 | Pancreatic, Lymphatic, Angiectasis | 4 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 3 | Congestion | | Infiltration Cellular, Plasma Cell | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Depletion Lymphoid | | Giant Cell | 2 2 1 | Lymphatic, Angiectasis | 4 4 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Depletion Lymphoid | | Fibrosis | 3 3 4 2 3 3 1 3| _____________________________________________________________________________________________________________________| Page 73 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 7| 7| 3| 4| 4| 7| 7| 7| 7| 4| 2| 7| 7| 4| 7| 7| 7| 7| 2| 7| 6| 4| 7| 6| DAY ON TEST | 7| 3| 3| 1| 6| 6| 3| 1| 3| 3| 6| 7| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 2| 3| 7| | 5| 4| 4| 5| 3| 2| 4| 7| 5| 4| 3| 5| 4| 4| 3| 4| 5| 4| 5| 6| 4| 9| 9| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 100 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 3 | Infarct | 3 2 3| Thrombosis | | Capsule, Fibrosis | | __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| Hemorrhage, Focal | | Hyperplasia, Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + M + + + + + + + + + + + + + + + + M M + + M| Lactation | 1 1 2 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Inflammation, Focal, Granulomatous | | Hair Follicle, Cyst | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Hemorrhage, Focal | | Peribronchial, Inflammation, Chronic | 2 2 2 | Pleura, Inflammation, Chronic, Focal | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + M + + +| Fungus | 3 4 3 4 3 4 4 4| Hyperkeratosis | 4 | Inflammation, Acute | 4 2 4 2 2 4 | Inflammation, Chronic, Focal | 2 2 2 | Inflammation, Chronic | 2 | Metaplasia, Squamous | 2 | Respiratory Epithelium, Necrosis | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | M | Cataract | | Retina, Degeneration | | _____________________________________________________________________________________________________________________| Page 74 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 7| 7| 3| 4| 4| 7| 7| 7| 7| 4| 2| 7| 7| 4| 7| 7| 7| 7| 2| 7| 6| 4| 7| 6| DAY ON TEST | 7| 3| 3| 1| 6| 6| 3| 1| 3| 3| 6| 7| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 2| 3| 7| | 5| 4| 4| 5| 3| 2| 4| 7| 5| 4| 3| 5| 4| 4| 3| 4| 5| 4| 5| 6| 4| 9| 9| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 100 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Glomerulosclerosis | | Nephropathy | 1 3 2 2 2 2 1 2 3 2 4 3 2 2 2 1 3 3 3 3 2| Medulla, Casts | X | Renal Tubule, Degeneration, Granular | 2 | Renal Tubule, Pigmentation, Bile | 3| Renal Tubule, Regeneration | 1 | __________________________________________________________________________| Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | X | Hemorrhage | | _____________________________________________________________________________________________________________________| Page 75 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 2| 6| 6| 2| 7| 4| 2| 7| 7| 7| 4| 2| 7| 7| 4| 7| 4| 7| 4| 0| 7| 2| 7| 2| DAY ON TEST | 5| 7| 7| 8| 7| 3| 6| 7| 3| 3| 3| 6| 7| 2| 3| 6| 3| 6| 3| 6| 4| 3| 7| 3| 7| | 0| 6| 5| 7| 6| 4| 3| 6| 4| 4| 4| 3| 5| 4| 4| 3| 4| 3| 4| 2| 3| 4| 5| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | 4 4 | __________________________________________________________________________| Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X 2 4 4 4 X| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | Parasite Metazoan | X 2 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | Atrophy | | Basophilic Focus | X X X X X X X X X X X X X | Clear Cell Focus | X X | Cyst | | Developmental Malformation | | Eosinophilic Focus | | Fatty Change | | Granuloma | 3 | Hepatodiaphragmatic Nodule | X | Infarct | 4 | Necrosis, Focal | | Thrombosis | X | Bile Duct, Dilatation | | Bile Duct, Hyperplasia | 3 3 1 3 3 1 3 4 1 2 2 3 2 2 | Lymphatic, Angiectasis, Focal | | __________________________________________________________________________| Mesentery | + + + | Fat, Necrosis | 3 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Acinus, Atrophy | 4 1 2 2 2 2 4 3 1 | Acinus, Hyperplasia, Focal | | Artery, Inflammation, Chronic | | __________________________________________________________________________| Pharynx | | Palate, Inflammation, Chronic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | | Ulcer | 4 | _____________________________________________________________________________________________________________________| Page 76 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 2| 6| 6| 2| 7| 4| 2| 7| 7| 7| 4| 2| 7| 7| 4| 7| 4| 7| 4| 0| 7| 2| 7| 2| DAY ON TEST | 5| 7| 7| 8| 7| 3| 6| 7| 3| 3| 3| 6| 7| 2| 3| 6| 3| 6| 3| 6| 4| 3| 7| 3| 7| | 0| 6| 5| 7| 6| 4| 3| 6| 4| 4| 4| 3| 5| 4| 4| 3| 4| 3| 4| 2| 3| 4| 5| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 3 3 1 | Hyperplasia, Lymphoid | | Submucosa, Fibrosis | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 3 2 4 2 3 2 2 2 3 1 1 2 2 3 | Inflammation, Chronic, Focal | 1 1 1 1| Artery, Inflammation, Chronic | | Atrium, Dilatation | | Ventricle, Dilatation | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + M + + + + + + + + + +| Cytoplasmic Alteration, Focal | 3 | Hyperplasia, Focal | | Vacuolization Cytoplasmic | 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +| Hemorrhage | | Hyperplasia, Focal | 1 2 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Cyst | X X | Pars Distalis, Hemorrhage | 4 | Pars Distalis, Hyperplasia, Focal | 1 1 2 2 | Pars Distalis, Inflammation, Chronic,| | Focal | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | | C-Cell, Hyperplasia | 1 | Follicle, Cyst | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 2 | _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 2| 6| 6| 2| 7| 4| 2| 7| 7| 7| 4| 2| 7| 7| 4| 7| 4| 7| 4| 0| 7| 2| 7| 2| DAY ON TEST | 5| 7| 7| 8| 7| 3| 6| 7| 3| 3| 3| 6| 7| 2| 3| 6| 3| 6| 3| 6| 4| 3| 7| 3| 7| | 0| 6| 5| 7| 6| 4| 3| 6| 4| 4| 4| 3| 5| 4| 4| 3| 4| 3| 4| 2| 3| 4| 5| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Cyst | X X X X | Ectasia | 3 | Inflammation, Acute | 2 2 | Inflammation, Chronic, Focal | 2 3 3 3| Inflammation, Chronic | 2 2 1 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 2 2 2 3 2 | Dilatation | | Inflammation, Focal | 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 2 3 3 4 4 3 3 3 4 4 | Dilatation | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | | Bilateral, Interstitial Cell, | | Hyperplasia | | Interstitial Cell, Hyperplasia | 3 | Seminiferous Tubule, Atrophy | 4 4 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 4 4 3 4 3 | __________________________________________________________________________| Lymph Node | + + + + + + + + + | Inguinal, Lymphatic, Angiectasis | | Mediastinal, Congestion | 3 | Mediastinal, Granuloma | | Mediastinal, Pigmentation | 3 | Mediastinal, Lymphatic, Angiectasis | 2 | Pancreatic, Hyperplasia, Lymphoid | | Pancreatic, Lymphatic, Angiectasis | 3 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| Angiectasis | | Congestion | | Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 4 | Depletion Lymphoid | | Giant Cell | 2 2 2 1 2 1| Lymphatic, Angiectasis | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Depletion Lymphoid | | Fibrosis | 3 4 3 4 | _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 2| 6| 6| 2| 7| 4| 2| 7| 7| 7| 4| 2| 7| 7| 4| 7| 4| 7| 4| 0| 7| 2| 7| 2| DAY ON TEST | 5| 7| 7| 8| 7| 3| 6| 7| 3| 3| 3| 6| 7| 2| 3| 6| 3| 6| 3| 6| 4| 3| 7| 3| 7| | 0| 6| 5| 7| 6| 4| 3| 6| 4| 4| 4| 3| 5| 4| 4| 3| 4| 3| 4| 2| 3| 4| 5| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | | Infarct | 4 4 | Thrombosis | X | Capsule, Fibrosis | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | 2 | Hyperplasia, Lymphoid | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + M + + M + M + + + + + + + + + + + + + M + + +| Lactation | 2 1 1 1 1 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 | Inflammation, Focal, Granulomatous | | Hair Follicle, Cyst | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 4 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage, Focal | 4 | Peribronchial, Inflammation, Chronic | 2 2 2 1 2 2| Pleura, Inflammation, Chronic, Focal | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | 4 4 3 4 4 | Hyperkeratosis | | Inflammation, Acute | 3 | Inflammation, Chronic, Focal | 2 2 2 1 2 2| Inflammation, Chronic | 2 1 2 2 | Metaplasia, Squamous | | Respiratory Epithelium, Necrosis | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 2 | Retina, Degeneration | 3 | _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 2| 6| 6| 2| 7| 4| 2| 7| 7| 7| 4| 2| 7| 7| 4| 7| 4| 7| 4| 0| 7| 2| 7| 2| DAY ON TEST | 5| 7| 7| 8| 7| 3| 6| 7| 3| 3| 3| 6| 7| 2| 3| 6| 3| 6| 3| 6| 4| 3| 7| 3| 7| | 0| 6| 5| 7| 6| 4| 3| 6| 4| 4| 4| 3| 5| 4| 4| 3| 4| 3| 4| 2| 3| 4| 5| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Glomerulosclerosis | 3 | Nephropathy | 1 2 2 2 1 2 2 3 2 2 1 1 1 1 3 2 2 1| Medulla, Casts | | Renal Tubule, Degeneration, Granular | | Renal Tubule, Pigmentation, Bile | 1 | Renal Tubule, Regeneration | 1 1 1 | __________________________________________________________________________| Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | | Hemorrhage | 2 | _____________________________________________________________________________________________________________________| Page 80 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 2| 5| 6| 7| 7| 5| 6| 7| 4| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 3| 5| 3| 3| 4| 2| 3| 6| 3| 0| 9| 3| 3| 0| 3| 3| 3| 3| 3| | | | 6| 3| 0| 5| 5| 7| 3| 5| 2| 5| 0| 6| 5| 5| 9| 5| 5| 5| 5| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 100 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + A + + + + + + + + A + + + + + | 66 | Parasite Metazoan | 3 2 | 8 2.9| __________________________________________________________________________|____________| Intestine Large, Rectum | + + A + + + + + + + + + + + A + + + + + | 67 | Parasite Metazoan | 4 4 2 2 3 | 15 3.2| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + A + + + + + A + + A + + + + + | 64 | Hyperplasia, Lymphoid | | 1 4.0| Parasite Metazoan | X 4 | 4 3.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + | 69 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + A + + + + + + + + A + + + + + | 66 | Hyperplasia, Lymphoid | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + A + + + + + A + + A + + + + + | 63 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis, Focal | | 7 2.3| Atrophy | 2 | 1 2.0| Basophilic Focus | X X X X X X X X X X X X X X X X | 46 | Clear Cell Focus | X X X | 8 | Cyst | | 1 | Developmental Malformation | | 1 | Eosinophilic Focus | X | 1 | Fatty Change | 3 | 5 1.8| Granuloma | | 1 3.0| Hepatodiaphragmatic Nodule | X | 3 | Infarct | | 1 4.0| Necrosis, Focal | | 1 2.0| Thrombosis | | 1 | Bile Duct, Dilatation | | 1 4.0| Bile Duct, Hyperplasia | 2 2 1 4 2 3 4 4 4 | 31 2.5| Lymphatic, Angiectasis, Focal | 3 | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + | 7 | Fat, Necrosis | 3 4 | 5 3.2| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis | | 1 4.0| Acinus, Atrophy | 4 2 4 1 2 4 4 4 3 | 28 2.4| Acinus, Hyperplasia, Focal | 3 | 2 3.0| Artery, Inflammation, Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Pharynx | | 1 | Palate, Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 81 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 2| 5| 6| 7| 7| 5| 6| 7| 4| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 3| 5| 3| 3| 4| 2| 3| 6| 3| 0| 9| 3| 3| 0| 3| 3| 3| 3| 3| | | | 6| 3| 0| 5| 5| 7| 3| 5| 2| 5| 0| 6| 5| 5| 9| 5| 5| 5| 5| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 100 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Atrophy | 2 | 1 2.0| Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 | Inflammation, Chronic, Focal | 1 | 1 1.0| Ulcer | | 1 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 | Erosion | 2 | 5 2.6| Hyperplasia, Lymphoid | | 2 2.5| Submucosa, Fibrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | Cardiomyopathy | 1 2 1 3 2 3 2 3 2 2 1 2 1 | 50 2.1| Inflammation, Chronic, Focal | 1 | 6 1.0| Artery, Inflammation, Chronic | | 1 2.0| Atrium, Dilatation | | 1 4.0| Ventricle, Dilatation | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 69 | Cytoplasmic Alteration, Focal | 2 2 | 4 2.3| Hyperplasia, Focal | 4 | 1 4.0| Vacuolization Cytoplasmic | 3 | 2 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + + A + + + + + + + + + + + + + + + + + | 68 | Hemorrhage | | 1 4.0| Hyperplasia, Focal | 3 2 | 12 1.8| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + | 66 | Hyperplasia, Focal | 2 | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 69 | Pars Distalis, Angiectasis | 2 2 | 2 2.0| Pars Distalis, Cyst | | 3 | Pars Distalis, Hemorrhage | | 1 4.0| Pars Distalis, Hyperplasia, Focal | 2 4 2 | 14 2.1| Pars Distalis, Inflammation, Chronic,| | | Focal | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 69 | Ultimobranchial Cyst | | 1 | C-Cell, Hyperplasia | 3 1 | 6 1.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 82 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 2| 5| 6| 7| 7| 5| 6| 7| 4| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 3| 5| 3| 3| 4| 2| 3| 6| 3| 0| 9| 3| 3| 0| 3| 3| 3| 3| 3| | | | 6| 3| 0| 5| 5| 7| 3| 5| 2| 5| 0| 6| 5| 5| 9| 5| 5| 5| 5| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 100 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Follicle, Cyst | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + M + + + + + + + + + + + + + + + + + | 69 | Depletion Cellular | 2 | 2 2.5| __________________________________________________________________________|____________| Preputial Gland | + + M + + M + + + + + + + + + + + + + + | 67 | Abscess | | 4 2.3| Cyst | | 5 | Ectasia | 2 | 2 2.5| Inflammation, Acute | 3 | 5 2.4| Inflammation, Chronic, Focal | 2 | 8 2.3| Inflammation, Chronic | 3 3 | 11 2.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + | 70 | Atrophy | | 11 2.3| Dilatation | | 1 2.0| Inflammation, Focal | | 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 | Atrophy | 3 3 3 4 4 3 3 3 3 3 | 36 3.4| Dilatation | 3 2 | 3 2.7| __________________________________________________________________________|____________| Testes | + + M + + + + + + + + + + + + + + + + + | 69 | Hemorrhage, Focal | 4 | 1 4.0| Bilateral, Interstitial Cell, | | | Hyperplasia | | 1 2.0| Interstitial Cell, Hyperplasia | 3 3 3 | 5 2.8| Seminiferous Tubule, Atrophy | 4 | 5 3.4| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperplasia | 2 4 2 2 2 4 | 19 3.1| __________________________________________________________________________|____________| Lymph Node | + + + + | 19 | Inguinal, Lymphatic, Angiectasis | 3 | 1 3.0| Mediastinal, Congestion | | 1 3.0| Mediastinal, Granuloma | | 1 4.0| Mediastinal, Pigmentation | | 1 3.0| Mediastinal, Lymphatic, Angiectasis | | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 83 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 2| 5| 6| 7| 7| 5| 6| 7| 4| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 3| 5| 3| 3| 4| 2| 3| 6| 3| 0| 9| 3| 3| 0| 3| 3| 3| 3| 3| | | | 6| 3| 0| 5| 5| 7| 3| 5| 2| 5| 0| 6| 5| 5| 9| 5| 5| 5| 5| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 100 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Pancreatic, Hyperplasia, Lymphoid | | 1 3.0| Pancreatic, Lymphatic, Angiectasis | 3 | 4 3.3| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 69 | Angiectasis | | 2 3.0| Congestion | 4 | 1 4.0| Infiltration Cellular, Plasma Cell | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis | 4 3 4 | 5 3.6| Depletion Lymphoid | 4 | 1 4.0| Giant Cell | 2 | 10 1.7| Lymphatic, Angiectasis | | 2 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 70 | Congestion | 2 | 2 2.5| Depletion Lymphoid | 4 3 | 2 3.5| Fibrosis | 2 3 3 4 4 | 17 3.1| Hematopoietic Cell Proliferation | 3 | 2 3.0| Infarct | 4 2 | 7 3.1| Thrombosis | | 1 | Capsule, Fibrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Thymus | + + + + + + M + + + + + + M + + + + + + | 67 | Hemorrhage, Focal | | 1 2.0| Hyperplasia, Lymphoid | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M + + + M + + M + M M + + + + + M + | 53 | Lactation | 1 2 2 1 | 14 1.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 70 | Acanthosis | | 1 3.0| Inflammation, Focal, Granulomatous | 3 | 1 3.0| Hair Follicle, Cyst | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperostosis | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | Hemorrhage | | 2 4.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 84 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 2| 5| 6| 7| 7| 5| 6| 7| 4| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 3| 5| 3| 3| 4| 2| 3| 6| 3| 0| 9| 3| 3| 0| 3| 3| 3| 3| 3| | | | 6| 3| 0| 5| 5| 7| 3| 5| 2| 5| 0| 6| 5| 5| 9| 5| 5| 5| 5| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 100 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Congestion | | 1 3.0| Hemorrhage, Focal | | 1 4.0| Peribronchial, Inflammation, Chronic | 2 | 10 1.9| Pleura, Inflammation, Chronic, Focal | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 69 | Fungus | 4 4 4 4 2 | 18 3.7| Hyperkeratosis | | 1 4.0| Inflammation, Acute | 2 1 | 9 2.7| Inflammation, Chronic, Focal | 2 | 10 1.9| Inflammation, Chronic | 2 2 | 7 1.9| Metaplasia, Squamous | | 1 2.0| Respiratory Epithelium, Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 3 | Cataract | | 1 2.0| Retina, Degeneration | 4 | 2 3.5| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Cyst | X | 2 | Glomerulosclerosis | | 1 3.0| Nephropathy | 2 3 4 1 2 2 1 1 1 2 4 1 1 2 1 1 2 4 | 57 2.0| Medulla, Casts | | 1 | Renal Tubule, Degeneration, Granular | 3 | 2 2.5| Renal Tubule, Pigmentation, Bile | | 2 2.0| Renal Tubule, Regeneration | | 4 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + M + + A + + + + + A + + A + + + + + | 64 | Calculus Micro Observation Only | | 1 | Hemorrhage | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 85 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 7| 7| 7| 7| 4| 7| 7| 7| 6| 3| 4| 3| 6| 7| 7| 4| 2| 7| 7| 4| 7| 7| 2| 7| DAY ON TEST | 7| 3| 3| 3| 3| 6| 3| 3| 3| 5| 2| 6| 8| 2| 3| 3| 6| 7| 3| 3| 6| 0| 3| 7| 2| | 5| 1| 1| 1| 1| 2| 1| 1| 1| 3| 5| 3| 3| 4| 1| 1| 3| 5| 4| 1| 3| 0| 1| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 500 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + M + + + + + + + A + + + + + + + + + + +| Parasite Metazoan | X 4 4 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| Parasite Metazoan | 2 4 X 3 X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + A + + A + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + A + + + + + + + + + + A| Peyer's Patch, Hyperplasia | 3 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | Atrophy | 3| Basophilic Focus | X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X | Developmental Malformation | X | Fatty Change | 1 2 | Fibrosis, Focal | | Granuloma | 4 2 | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | | Necrosis, Focal | | Thrombosis | | Bile Duct, Hyperplasia | 2 3 3 3 1 3 3 2 2| Lymphatic, Angiectasis, Focal | 3 4 | __________________________________________________________________________| Mesentery | + + + + + | Accessory Spleen | | Cyst | X | Fibrosis | | Fat, Necrosis | 3 3 3 3 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Pigmentation, Focal | | Acinus, Atrophy | 3 2 3 2 2 1 | Acinus, Hyperplasia, Focal | | Artery, Inflammation, Chronic | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 4| Hyperplasia, Lymphoid | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 86 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 7| 7| 7| 7| 4| 7| 7| 7| 6| 3| 4| 3| 6| 7| 7| 4| 2| 7| 7| 4| 7| 7| 2| 7| DAY ON TEST | 7| 3| 3| 3| 3| 6| 3| 3| 3| 5| 2| 6| 8| 2| 3| 3| 6| 7| 3| 3| 6| 0| 3| 7| 2| | 5| 1| 1| 1| 1| 2| 1| 1| 1| 3| 5| 3| 3| 4| 1| 1| 3| 5| 4| 1| 3| 0| 1| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 500 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 2 1 1 2 1 2 1 2 2 1 2 3 2 2 2| Inflammation, Chronic, Focal | | Mineralization | | Artery, Inflammation, Chronic | | Atrium, Thrombosis | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | 3| Hyperplasia | | Vacuolization Cytoplasmic | 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 3 1 2 2 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | | Pars Distalis, Hyperplasia, Focal | 1 3 2 2 2 1 3 2 | Pars Intermedia, Hyperplasia, Focal | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2| Follicle, Cyst | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | | Spermatocele | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X | Ectasia | | Inflammation, Acute | | Inflammation, Chronic, Focal | 3 2 3 | Inflammation, Chronic | 2 2 2 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 2 3 3 3 4| Congestion | | Dilatation | | Inflammation, Acute | | _____________________________________________________________________________________________________________________| Page 87 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 7| 7| 7| 7| 4| 7| 7| 7| 6| 3| 4| 3| 6| 7| 7| 4| 2| 7| 7| 4| 7| 7| 2| 7| DAY ON TEST | 7| 3| 3| 3| 3| 6| 3| 3| 3| 5| 2| 6| 8| 2| 3| 3| 6| 7| 3| 3| 6| 0| 3| 7| 2| | 5| 1| 1| 1| 1| 2| 1| 1| 1| 3| 5| 3| 3| 4| 1| 1| 3| 5| 4| 1| 3| 0| 1| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 500 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 3 3 4 4 2 4 4| Cyst | | Dilatation | 3 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, | | Hyperplasia | 2 2 3 | Interstitial Cell, Hyperplasia | | Seminiferous Tubule, Atrophy | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma | 4 | Hyperplasia | 4 3 4 1 2 3 4 2 2| Myelofibrosis | 1 1 | __________________________________________________________________________| Lymph Node | + + + + + + + +| Lumbar, Lymphatic, Angiectasis | 3| Mediastinal, Congestion | 2 | Mediastinal, Lymphatic, Angiectasis | | Pancreatic, Lymphatic, Angiectasis | 4 3 | Renal, Pigmentation | 4 | Renal, Lymphatic, Angiectasis | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Depletion Lymphoid | 3| Lymphatic, Angiectasis | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Depletion Lymphoid | 4| Giant Cell | 2 1 2 | Hyperplasia, Lymphoid | | Lymphatic, Angiectasis | 4 4 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Depletion Lymphoid | 4 2 4| Fibrosis | 2 3 4 | Hematopoietic Cell Proliferation | 2 | Capsule, Fibrosis | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +| Cyst | | Depletion Lymphoid | 4| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + + + + + + + + M + + + + + + + M M + +| _____________________________________________________________________________________________________________________| Page 88 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 7| 7| 7| 7| 4| 7| 7| 7| 6| 3| 4| 3| 6| 7| 7| 4| 2| 7| 7| 4| 7| 7| 2| 7| DAY ON TEST | 7| 3| 3| 3| 3| 6| 3| 3| 3| 5| 2| 6| 8| 2| 3| 3| 6| 7| 3| 3| 6| 0| 3| 7| 2| | 5| 1| 1| 1| 1| 2| 1| 1| 1| 3| 5| 3| 3| 4| 1| 1| 3| 5| 4| 1| 3| 0| 1| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 500 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Lactation | 2 1 1 | __________________________________________________________________________| Skin | M + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 3 | Fibrosis, Focal | | Ulcer | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | | __________________________________________________________________________| Skeletal Muscle | | Fibrosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | +| Degeneration | 4| __________________________________________________________________________| Spinal Cord | +| Degeneration | 4| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma | | Peribronchial, Inflammation, Chronic | 2 2 2 | __________________________________________________________________________| Nose | + + + + M + + + + + + + + + + + + + + + + + + + +| Fungus | 4 3 4| Hyperkeratosis | | Inflammation, Acute | | Inflammation, Chronic, Focal | 2 2 1 | Inflammation, Chronic | 2 2 2 2 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 2 | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Glomerulosclerosis | 3 | Nephropathy | 1 2 2 1 1 2 2 1 2 1 2 1 3 4 1 1 1 1 1 1 1| Renal Tubule, Degeneration, Granular | | Renal Tubule, Pigmentation, Bile | 3 4 4 | Renal Tubule, Regeneration | 1 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + A + + A + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 89 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 7| 7| 7| 7| 4| 7| 7| 7| 6| 3| 4| 3| 6| 7| 7| 4| 2| 7| 7| 4| 7| 7| 2| 7| DAY ON TEST | 7| 3| 3| 3| 3| 6| 3| 3| 3| 5| 2| 6| 8| 2| 3| 3| 6| 7| 3| 3| 6| 0| 3| 7| 2| | 5| 1| 1| 1| 1| 2| 1| 1| 1| 3| 5| 3| 3| 4| 1| 1| 3| 5| 4| 1| 3| 0| 1| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 500 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Calculus Micro Observation Only | | Ectasia | 2| Hemorrhage | 3| Inflammation, Chronic, Focal | | _____________________________________________________________________________________________________________________| Page 90 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 2| 7| 4| 7| 4| 7| 7| 7| 4| 5| 7| 7| 4| 6| 7| 7| 7| 2| 7| 6| 7| 4| 6| 6| DAY ON TEST | 7| 7| 0| 0| 3| 6| 3| 3| 3| 6| 4| 3| 2| 6| 7| 3| 3| 3| 7| 3| 8| 3| 6| 3| 7| | 5| 5| 1| 6| 1| 3| 1| 1| 1| 3| 2| 1| 2| 2| 4| 4| 4| 4| 6| 4| 1| 1| 2| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + A + + + + + + A + + + + + + + + + + + + + +| Parasite Metazoan | 2 2 2 4 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| Parasite Metazoan | X X 2 4 4 4 3 4 | __________________________________________________________________________| Intestine Large, Cecum | + + A A + + + + + + A + + + + + + + + + + + + + +| Parasite Metazoan | 4 | __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + A A + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A A + + + + + + A + + + + + + + + + A + + + +| Peyer's Patch, Hyperplasia | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 3 | Atrophy | 3 | Basophilic Focus | X X X X X X X X X X X X X X X | Clear Cell Focus | X X X X| Developmental Malformation | X | Fatty Change | 2 1 | Fibrosis, Focal | | Granuloma | | Hepatodiaphragmatic Nodule | X | Mixed Cell Focus | X | Necrosis, Focal | 2 | Thrombosis | | Bile Duct, Hyperplasia | 2 4 3 4 3 2 3| Lymphatic, Angiectasis, Focal | 3 | __________________________________________________________________________| Mesentery | + + + + + + +| Accessory Spleen | X | Cyst | | Fibrosis | | Fat, Necrosis | 2 3 3 3| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Pigmentation, Focal | 3 | Acinus, Atrophy | 2 1 4 1 2 2 | Acinus, Hyperplasia, Focal | | Artery, Inflammation, Chronic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + M + + + +| Erosion | 3 3 | Hyperplasia, Lymphoid | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 91 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 2| 7| 4| 7| 4| 7| 7| 7| 4| 5| 7| 7| 4| 6| 7| 7| 7| 2| 7| 6| 7| 4| 6| 6| DAY ON TEST | 7| 7| 0| 0| 3| 6| 3| 3| 3| 6| 4| 3| 2| 6| 7| 3| 3| 3| 7| 3| 8| 3| 6| 3| 7| | 5| 5| 1| 6| 1| 3| 1| 1| 1| 3| 2| 1| 2| 2| 4| 4| 4| 4| 6| 4| 1| 1| 2| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 2 2 2 3 2 2 2 2 3 3 1 1 1 3 3 3 1 2| Inflammation, Chronic, Focal | 1 2 | Mineralization | | Artery, Inflammation, Chronic | | Atrium, Thrombosis | X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | | Hyperplasia | 2 2 | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 2 1 2 2 2 1| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| Hyperplasia, Focal | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + A + + + + + + + + + + + + + +| Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 | Pars Intermedia, Hyperplasia, Focal | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 4 2| Follicle, Cyst | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | 3 | Spermatocele | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Ectasia | 3 | Inflammation, Acute | 3 | Inflammation, Chronic, Focal | 2 2 2 | Inflammation, Chronic | 2 2 2 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + M + + + + + + + + + + + +| Atrophy | 3 3 3 3 | Congestion | | Dilatation | 3 | Inflammation, Acute | | _____________________________________________________________________________________________________________________| Page 92 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 2| 7| 4| 7| 4| 7| 7| 7| 4| 5| 7| 7| 4| 6| 7| 7| 7| 2| 7| 6| 7| 4| 6| 6| DAY ON TEST | 7| 7| 0| 0| 3| 6| 3| 3| 3| 6| 4| 3| 2| 6| 7| 3| 3| 3| 7| 3| 8| 3| 6| 3| 7| | 5| 5| 1| 6| 1| 3| 1| 1| 1| 3| 2| 1| 2| 2| 4| 4| 4| 4| 6| 4| 1| 1| 2| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + M + + + + + + + + + + + +| Atrophy | 3 4 4 3 3 2 3 4 4 4 3 3 2 4| Cyst | X | Dilatation | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, | | Hyperplasia | 2 | Interstitial Cell, Hyperplasia | 2 | Seminiferous Tubule, Atrophy | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma | | Hyperplasia | 3 2 2 3 4 4 3 4 4 4 2 4| Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + | Lumbar, Lymphatic, Angiectasis | | Mediastinal, Congestion | | Mediastinal, Lymphatic, Angiectasis | 4 3 | Pancreatic, Lymphatic, Angiectasis | 3 | Renal, Pigmentation | | Renal, Lymphatic, Angiectasis | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + M +| Angiectasis | 2 3 | Depletion Lymphoid | | Lymphatic, Angiectasis | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + A + + + + + + + + + + + + + +| Angiectasis | 4 | Depletion Lymphoid | | Giant Cell | 1 2 2 | Hyperplasia, Lymphoid | 3 | Lymphatic, Angiectasis | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 4 | Depletion Lymphoid | 3 4 | Fibrosis | 2 4 2 | Hematopoietic Cell Proliferation | | Capsule, Fibrosis | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| Cyst | X | Depletion Lymphoid | 4 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + M + + M + + + + + + M + + + + + M + + + +| _____________________________________________________________________________________________________________________| Page 93 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 2| 7| 4| 7| 4| 7| 7| 7| 4| 5| 7| 7| 4| 6| 7| 7| 7| 2| 7| 6| 7| 4| 6| 6| DAY ON TEST | 7| 7| 0| 0| 3| 6| 3| 3| 3| 6| 4| 3| 2| 6| 7| 3| 3| 3| 7| 3| 8| 3| 6| 3| 7| | 5| 5| 1| 6| 1| 3| 1| 1| 1| 3| 2| 1| 2| 2| 4| 4| 4| 4| 6| 4| 1| 1| 2| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Lactation | 1 1 1 1 1 1 2| __________________________________________________________________________| Skin | + M + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Fibrosis, Focal | | Ulcer | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 2 2 | __________________________________________________________________________| Skeletal Muscle | + + + + | Fibrosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | | Degeneration | | __________________________________________________________________________| Spinal Cord | | Degeneration | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma | 2 2 2 | Peribronchial, Inflammation, Chronic | 2 2 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | 3 3 4 3 4 3 4 | Hyperkeratosis | 4 | Inflammation, Acute | 1 | Inflammation, Chronic, Focal | 1 2 2 | Inflammation, Chronic | 2 2 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 4 4 | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Glomerulosclerosis | | Nephropathy | 2 2 3 2 2 2 2 2 2 1 2 2 3 2 2 2 2 2 1 1 1| Renal Tubule, Degeneration, Granular | 3 3 | Renal Tubule, Pigmentation, Bile | 2 | Renal Tubule, Regeneration | 1 1 | __________________________________________________________________________| Urinary Bladder | + + + A + + + + + + A + M + A + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 94 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 2| 7| 4| 7| 4| 7| 7| 7| 4| 5| 7| 7| 4| 6| 7| 7| 7| 2| 7| 6| 7| 4| 6| 6| DAY ON TEST | 7| 7| 0| 0| 3| 6| 3| 3| 3| 6| 4| 3| 2| 6| 7| 3| 3| 3| 7| 3| 8| 3| 6| 3| 7| | 5| 5| 1| 6| 1| 3| 1| 1| 1| 3| 2| 1| 2| 2| 4| 4| 4| 4| 6| 4| 1| 1| 2| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Calculus Micro Observation Only | X | Ectasia | | Hemorrhage | | Inflammation, Chronic, Focal | | _____________________________________________________________________________________________________________________| Page 95 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 7| 4| 7| 6| 7| 7| 2| 2| 7| 7| 7| 7| 5| 2| | | DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 6| 3| 7| 3| 3| 7| 7| 3| 3| 3| 3| 6| 7| | | | 0| 2| 6| 1| 0| 0| 0| 2| 0| 7| 4| 4| 5| 6| 4| 1| 1| 1| 6| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + | 65 | Parasite Metazoan | 2 2 3 2 | 11 2.7| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 68 | Parasite Metazoan | 4 4 | 15 3.5| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + | 64 | Parasite Metazoan | X X | 3 4.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + | 66 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + | 64 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + | 62 | Peyer's Patch, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis, Focal | | 3 2.3| Atrophy | | 2 3.0| Basophilic Focus | X X X X X X X X X X X | 41 | Clear Cell Focus | X X X X X X | 14 | Developmental Malformation | X | 3 | Fatty Change | | 4 1.5| Fibrosis, Focal | 2 | 1 2.0| Granuloma | 2 | 3 2.7| Hepatodiaphragmatic Nodule | | 3 | Mixed Cell Focus | | 1 | Necrosis, Focal | | 1 2.0| Thrombosis | X | 1 | Bile Duct, Hyperplasia | 3 2 4 | 19 2.7| Lymphatic, Angiectasis, Focal | 3 | 4 3.3| __________________________________________________________________________|____________| Mesentery | + + | 14 | Accessory Spleen | | 1 | Cyst | | 1 | Fibrosis | 2 | 1 2.0| Fat, Necrosis | 3 | 10 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + A + | 69 | Pigmentation, Focal | | 1 3.0| Acinus, Atrophy | 3 1 3 2 3 3 2 2 2 2 | 22 2.2| Acinus, Hyperplasia, Focal | 2 | 1 2.0| Artery, Inflammation, Chronic | 4 | 2 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 | Cyst Epithelial Inclusion | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 96 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 7| 4| 7| 6| 7| 7| 2| 2| 7| 7| 7| 7| 5| 2| | | DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 6| 3| 7| 3| 3| 7| 7| 3| 3| 3| 3| 6| 7| | | | 0| 2| 6| 1| 0| 0| 0| 2| 0| 7| 4| 4| 5| 6| 4| 1| 1| 1| 6| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + | 68 | Erosion | | 3 3.3| Hyperplasia, Lymphoid | | 2 2.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + | 70 | Cardiomyopathy | 1 2 2 3 1 2 3 1 1 3 3 1 | 49 1.9| Inflammation, Chronic, Focal | 1 1 1 | 5 1.2| Mineralization | 1 | 1 1.0| Artery, Inflammation, Chronic | 2 | 1 2.0| Atrium, Thrombosis | | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + | 69 | Cytoplasmic Alteration, Focal | | 1 3.0| Hyperplasia | | 2 2.0| Vacuolization Cytoplasmic | | 1 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + | 69 | Hyperplasia, Focal | 1 1 1 1 | 17 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 68 | Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 68 | Pars Distalis, Cyst | X | 3 | Pars Distalis, Hyperplasia, Focal | 2 2 2 2 | 17 2.0| Pars Intermedia, Hyperplasia, Focal | 3 | 1 3.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 | C-Cell, Hyperplasia | 1 1 2 | 8 2.0| Follicle, Cyst | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 | Depletion Cellular | 4 | 2 3.5| Spermatocele | X | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 97 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 7| 4| 7| 6| 7| 7| 2| 2| 7| 7| 7| 7| 5| 2| | | DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 6| 3| 7| 3| 3| 7| 7| 3| 3| 3| 3| 6| 7| | | | 0| 2| 6| 1| 0| 0| 0| 2| 0| 7| 4| 4| 5| 6| 4| 1| 1| 1| 6| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Cyst | | 2 | Ectasia | | 1 3.0| Inflammation, Acute | | 1 3.0| Inflammation, Chronic, Focal | 2 1 | 8 2.1| Inflammation, Chronic | 2 3 | 11 2.2| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + | 69 | Atrophy | 3 | 12 2.8| Congestion | 3 | 1 3.0| Dilatation | | 1 3.0| Inflammation, Acute | 2 2 | 2 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 69 | Atrophy | 4 4 3 4 3 4 4 3 2 3 3 3 | 38 3.4| Cyst | | 1 | Dilatation | 4 | 2 3.5| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 70 | Bilateral, Interstitial Cell, | | | Hyperplasia | 3 | 5 2.4| Interstitial Cell, Hyperplasia | 4 | 2 3.0| Seminiferous Tubule, Atrophy | 3 | 2 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 | Granuloma | | 1 4.0| Hyperplasia | 4 4 | 23 3.1| Myelofibrosis | | 2 1.0| __________________________________________________________________________|____________| Lymph Node | + + + | 16 | Lumbar, Lymphatic, Angiectasis | | 1 3.0| Mediastinal, Congestion | | 1 2.0| Mediastinal, Lymphatic, Angiectasis | 3 | 3 3.3| Pancreatic, Lymphatic, Angiectasis | 2 | 4 3.0| Renal, Pigmentation | | 1 4.0| Renal, Lymphatic, Angiectasis | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 68 | Angiectasis | 2 3 | 4 2.5| Depletion Lymphoid | | 1 3.0| Lymphatic, Angiectasis | 3 | 2 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 68 | Angiectasis | 4 | 2 4.0| Depletion Lymphoid | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 98 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 7| 4| 7| 6| 7| 7| 2| 2| 7| 7| 7| 7| 5| 2| | | DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 6| 3| 7| 3| 3| 7| 7| 3| 3| 3| 3| 6| 7| | | | 0| 2| 6| 1| 0| 0| 0| 2| 0| 7| 4| 4| 5| 6| 4| 1| 1| 1| 6| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Giant Cell | 1 1 1 2 | 10 1.5| Hyperplasia, Lymphoid | | 1 3.0| Lymphatic, Angiectasis | 4 | 3 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 70 | Congestion | | 1 4.0| Depletion Lymphoid | 3 | 6 3.3| Fibrosis | 3 4 2 | 9 2.9| Hematopoietic Cell Proliferation | | 1 2.0| Capsule, Fibrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + M + + + + + + + + | 67 | Cyst | X | 2 | Depletion Lymphoid | | 2 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + M + M + I + M + M + M + M + + + + | 53 | Lactation | 1 2 | 12 1.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + | 68 | Abscess | | 1 3.0| Fibrosis, Focal | 4 | 1 4.0| Ulcer | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + | 70 | Hyperostosis | | 3 2.0| __________________________________________________________________________|____________| Skeletal Muscle | + + | 6 | Fibrosis | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | Degeneration | | 1 4.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | Degeneration | | 1 4.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + | 70 | Granuloma | | 3 2.0| Peribronchial, Inflammation, Chronic | 2 2 2 | 9 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + | 69 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 99 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 7| 4| 7| 6| 7| 7| 2| 2| 7| 7| 7| 7| 5| 2| | | DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 6| 3| 7| 3| 3| 7| 7| 3| 3| 3| 3| 6| 7| | | | 0| 2| 6| 1| 0| 0| 0| 2| 0| 7| 4| 4| 5| 6| 4| 1| 1| 1| 6| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Fungus | 4 3 4 4 2 4 | 16 3.5| Hyperkeratosis | | 1 4.0| Inflammation, Acute | | 1 1.0| Inflammation, Chronic, Focal | 2 2 2 2 | 10 1.8| Inflammation, Chronic | 2 2 4 | 13 2.2| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + | 70 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 3 | Cataract | | 3 3.3| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 70 | Glomerulosclerosis | | 1 3.0| Nephropathy | 2 1 2 1 2 2 2 4 2 4 2 2 2 4 2 1 1 | 59 1.8| Renal Tubule, Degeneration, Granular | | 2 3.0| Renal Tubule, Pigmentation, Bile | 3 | 5 3.2| Renal Tubule, Regeneration | 1 1 | 6 1.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + A + | 63 | Calculus Micro Observation Only | X X | 3 | Ectasia | | 1 2.0| Hemorrhage | | 1 3.0| Inflammation, Chronic, Focal | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 100 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 5| 3| 7| 2| 7| 1| 4| 7| 2| 4| 7| 4| 7| 7| 4| 4| 6| 7| 4| 3| 7| 4| 4| 7| DAY ON TEST | 5| 1| 8| 3| 7| 2| 8| 6| 2| 7| 6| 3| 3| 3| 3| 6| 6| 8| 3| 6| 5| 3| 6| 6| 3| | 3| 8| 6| 0| 5| 9| 7| 3| 9| 6| 2| 0| 9| 0| 0| 2| 2| 2| 0| 2| 7| 0| 2| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + A + + + A A + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X 4 3 2 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X 3 4 4 | __________________________________________________________________________| Intestine Large, Cecum | + A + + + A A + + + + + A + + + + + + + + + + + +| Hyperplasia, Lymphoid | | Parasite Metazoan | 2 X 2 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + A + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + A + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + A A + + + + + A + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | | Basophilic Focus | X X X X X X X X X X| Clear Cell Focus | X X| Developmental Malformation | X | Eosinophilic Focus | X | Fatty Change | | Granuloma | | Hepatodiaphragmatic Nodule | X X| Mixed Cell Focus | X | Necrosis, Focal | 3 | Bile Duct, Hyperplasia | 3 4 2 1 2 4 2 3 2| Lymphatic, Angiectasis, Focal | | __________________________________________________________________________| Mesentery | + + + | Accessory Spleen | | Fibrosis | 3 | Artery, Inflammation, Chronic | | Artery, Thrombosis | | Fat, Necrosis | 4 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis, Focal | 2 | Inflammation, Chronic, Focal | | Acinus, Atrophy | 4 2 2 2 1 2 4 2 2 2 4 2 3 2| Artery, Hypertrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 3 | Ulcer | 4 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| Page 101 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 5| 3| 7| 2| 7| 1| 4| 7| 2| 4| 7| 4| 7| 7| 4| 4| 6| 7| 4| 3| 7| 4| 4| 7| DAY ON TEST | 5| 1| 8| 3| 7| 2| 8| 6| 2| 7| 6| 3| 3| 3| 3| 6| 6| 8| 3| 6| 5| 3| 6| 6| 3| | 3| 8| 6| 0| 5| 9| 7| 3| 9| 6| 2| 0| 9| 0| 0| 2| 2| 2| 0| 2| 7| 0| 2| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Hyperkeratosis, Focal | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 3 2 3 3 2 3 4 2 1 2 2 2 2 2| Hypertrophy | | Inflammation, Chronic, Focal | 2 | Mineralization | 2 | Artery, Inflammation, Chronic | | Atrium, Dilatation | | Atrium, Thrombosis | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | 2 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 2 2 2 2 1 3| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 | Pars Distalis, Cyst | | Pars Distalis, Hemorrhage | 2 | Pars Distalis, Hyperplasia, Focal | 2 2 1 2 1 | Pars Intermedia, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Depletion Cellular | 2 | Dilatation | | Fibrosis | 2| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Cyst | | Ectasia | 4 | Inflammation, Chronic, Focal | 2 2 | Inflammation, Chronic | 2 2 2 1 2 3 2 1 3 3 | _____________________________________________________________________________________________________________________| Page 102 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 5| 3| 7| 2| 7| 1| 4| 7| 2| 4| 7| 4| 7| 7| 4| 4| 6| 7| 4| 3| 7| 4| 4| 7| DAY ON TEST | 5| 1| 8| 3| 7| 2| 8| 6| 2| 7| 6| 3| 3| 3| 3| 6| 6| 8| 3| 6| 5| 3| 6| 6| 3| | 3| 8| 6| 0| 5| 9| 7| 3| 9| 6| 2| 0| 9| 0| 0| 2| 2| 2| 0| 2| 7| 0| 2| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Metaplasia, Squamous | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 3 3 2 4| Hyperplasia, Focal | | Inflammation, Chronic | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 4 4 4 3 3 3 4 4 3 4 4| Dilatation | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, | | Hyperplasia | 2 | Interstitial Cell, Hyperplasia | | Seminiferous Tubule, Atrophy | 4 4 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 4 4 | Myelofibrosis | 4 | __________________________________________________________________________| Lymph Node | + + + | Mediastinal, Lymphatic, Angiectasis | | Pancreatic, Lymphatic, Angiectasis | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Congestion | 3 3 2 | Infiltration Cellular, Plasma Cell | 4 | Lymphatic, Angiectasis | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + + + + + +| Angiectasis | | Congestion | | Depletion Lymphoid | | Giant Cell | 1 1 | Lymphatic, Angiectasis | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Depletion Lymphoid | 3 2 | Fibrosis | 4 4 4 1 | Hemorrhage | 4 | Infarct | | Inflammation, Acute | | Necrosis, Focal | 2 | Pigmentation, Hemosiderin | 3 4 | __________________________________________________________________________| Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +| Congestion | | Depletion Lymphoid | 4 2 2 | _____________________________________________________________________________________________________________________| Page 103 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 5| 3| 7| 2| 7| 1| 4| 7| 2| 4| 7| 4| 7| 7| 4| 4| 6| 7| 4| 3| 7| 4| 4| 7| DAY ON TEST | 5| 1| 8| 3| 7| 2| 8| 6| 2| 7| 6| 3| 3| 3| 3| 6| 6| 8| 3| 6| 5| 3| 6| 6| 3| | 3| 8| 6| 0| 5| 9| 7| 3| 9| 6| 2| 0| 9| 0| 0| 2| 2| 2| 0| 2| 7| 0| 2| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphatic, Angiectasis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + M + + M + + + + + + + + + + + + + + M| Lactation | 2 2 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Fibrosis, Focal | | Ulcer | | Subcutaneous Tissue, Hemorrhage | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 4 | Hemorrhage | 3 | Meninges, Hemorrhage | | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | | Infiltration Cellular, Focal, | | Histiocyte | | Peribronchial, Inflammation, Chronic | 2 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | 4 X 3 4 4 | Inflammation, Acute | 3 3 4 | Inflammation, Chronic, Focal | 4 | Inflammation, Chronic | 2 2 2 2 3 2 2 2 | Metaplasia, Squamous | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | | Cataract | | Retina, Degeneration | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + A + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 104 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 6| 5| 3| 7| 2| 7| 1| 4| 7| 2| 4| 7| 4| 7| 7| 4| 4| 6| 7| 4| 3| 7| 4| 4| 7| DAY ON TEST | 5| 1| 8| 3| 7| 2| 8| 6| 2| 7| 6| 3| 3| 3| 3| 6| 6| 8| 3| 6| 5| 3| 6| 6| 3| | 3| 8| 6| 0| 5| 9| 7| 3| 9| 6| 2| 0| 9| 0| 0| 2| 2| 2| 0| 2| 7| 0| 2| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Autolysis | 3 | Cyst | | Nephropathy | 1 2 1 3 2 1 2 2 3 2 2 1 2 2 3 1 2 1 2 4| Pelvis, Epithelium, Hyperplasia | 2 | Renal Tubule, Pigmentation, Bile | | Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + A A + + + A + + + + + A + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 105 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 1| 7| 7| 2| 6| 7| 7| 7| 7| 1| 6| 6| 5| 7| 4| 7| 7| 7| 6| 7| 4| 7| 7| 7| DAY ON TEST | 7| 8| 2| 2| 7| 7| 3| 2| 2| 2| 8| 8| 7| 9| 3| 6| 2| 2| 2| 8| 3| 6| 2| 3| 3| | 6| 5| 9| 9| 6| 8| 0| 9| 9| 9| 0| 6| 5| 8| 0| 3| 9| 9| 9| 2| 0| 3| 2| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | 4 3 2 2| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | 4 3 2 | __________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + + A + + + + + + + + + + + A + +| Hyperplasia, Lymphoid | 3 | Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + A + + + + + + + + + + + + + +| Autolysis | 4 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 3 4 3 | Basophilic Focus | X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X | Developmental Malformation | X | Eosinophilic Focus | X X | Fatty Change | 2 1 1 | Granuloma | | Hepatodiaphragmatic Nodule | | Mixed Cell Focus | | Necrosis, Focal | | Bile Duct, Hyperplasia | 3 3 3 2 3 1 2 4 2 2| Lymphatic, Angiectasis, Focal | 2 3 2 | __________________________________________________________________________| Mesentery | + + + + +| Accessory Spleen | | Fibrosis | | Artery, Inflammation, Chronic | | Artery, Thrombosis | | Fat, Necrosis | 3 4 4 3 3| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis, Focal | | Inflammation, Chronic, Focal | | Acinus, Atrophy | 3 2 4 2 2 | Artery, Hypertrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | Ulcer | | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| Page 106 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 1| 7| 7| 2| 6| 7| 7| 7| 7| 1| 6| 6| 5| 7| 4| 7| 7| 7| 6| 7| 4| 7| 7| 7| DAY ON TEST | 7| 8| 2| 2| 7| 7| 3| 2| 2| 2| 8| 8| 7| 9| 3| 6| 2| 2| 2| 8| 3| 6| 2| 3| 3| | 6| 5| 9| 9| 6| 8| 0| 9| 9| 9| 0| 6| 5| 8| 0| 3| 9| 9| 9| 2| 0| 3| 2| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Hyperkeratosis, Focal | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 3 2 1 3 2 2 1 1 2 1 2 2 1 2 1 2 4| Hypertrophy | | Inflammation, Chronic, Focal | 2 | Mineralization | | Artery, Inflammation, Chronic | 3 | Atrium, Dilatation | 4 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 2 2 2 1 1 1 4 1 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Cyst | | Pars Distalis, Hemorrhage | | Pars Distalis, Hyperplasia, Focal | 3 1 2 3 2 | Pars Intermedia, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 4 4 4 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Depletion Cellular | 3 3 | Dilatation | 3 | Fibrosis | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 2 | Cyst | X X | Ectasia | | Inflammation, Chronic, Focal | 1 2 | Inflammation, Chronic | 2 2 3 3| _____________________________________________________________________________________________________________________| Page 107 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 1| 7| 7| 2| 6| 7| 7| 7| 7| 1| 6| 6| 5| 7| 4| 7| 7| 7| 6| 7| 4| 7| 7| 7| DAY ON TEST | 7| 8| 2| 2| 7| 7| 3| 2| 2| 2| 8| 8| 7| 9| 3| 6| 2| 2| 2| 8| 3| 6| 2| 3| 3| | 6| 5| 9| 9| 6| 8| 0| 9| 9| 9| 0| 6| 5| 8| 0| 3| 9| 9| 9| 2| 0| 3| 2| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Metaplasia, Squamous | 4 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 3 3 2 3 2 3 3 | Hyperplasia, Focal | | Inflammation, Chronic | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 2 4 4 4 3 4 2 4 4 2 4 3 4 4 3 4| Dilatation | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, | | Hyperplasia | | Interstitial Cell, Hyperplasia | | Seminiferous Tubule, Atrophy | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 4 2 4 3 4 4 2 3 2 4 | Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + | Mediastinal, Lymphatic, Angiectasis | 4 | Pancreatic, Lymphatic, Angiectasis | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Congestion | 2 | Infiltration Cellular, Plasma Cell | | Lymphatic, Angiectasis | 3| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 4 | Congestion | 2 | Depletion Lymphoid | 2 | Giant Cell | 2 | Lymphatic, Angiectasis | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Depletion Lymphoid | 4 2 3 2 | Fibrosis | 3 1 1 2 1 | Hemorrhage | | Infarct | | Inflammation, Acute | | Necrosis, Focal | | Pigmentation, Hemosiderin | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| Congestion | 3 | Depletion Lymphoid | 1 | _____________________________________________________________________________________________________________________| Page 108 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 1| 7| 7| 2| 6| 7| 7| 7| 7| 1| 6| 6| 5| 7| 4| 7| 7| 7| 6| 7| 4| 7| 7| 7| DAY ON TEST | 7| 8| 2| 2| 7| 7| 3| 2| 2| 2| 8| 8| 7| 9| 3| 6| 2| 2| 2| 8| 3| 6| 2| 3| 3| | 6| 5| 9| 9| 6| 8| 0| 9| 9| 9| 0| 6| 5| 8| 0| 3| 9| 9| 9| 2| 0| 3| 2| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphatic, Angiectasis | 4| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + + + + + + M M + + + + + + + + + + +| Lactation | 2 2 2 3 2 3 2 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 3 | Fibrosis, Focal | 4 | Ulcer | 2 | Subcutaneous Tissue, Hemorrhage | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 2 | Hemorrhage | 1 | Meninges, Hemorrhage | 2| __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | 3 | Infiltration Cellular, Focal, | | Histiocyte | 3 | Peribronchial, Inflammation, Chronic | 2 2 2 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | 4 4 4 3 | Inflammation, Acute | 4 3 3 2 | Inflammation, Chronic, Focal | 2 2 | Inflammation, Chronic | 2 3 2 3 2 | Metaplasia, Squamous | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + +| Cataract | 2 2 2| Retina, Degeneration | 3| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + A + + + + + + + + A + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 109 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 _____________________________________________________________________________________________________________________ | 2| 1| 7| 7| 2| 6| 7| 7| 7| 7| 1| 6| 6| 5| 7| 4| 7| 7| 7| 6| 7| 4| 7| 7| 7| DAY ON TEST | 7| 8| 2| 2| 7| 7| 3| 2| 2| 2| 8| 8| 7| 9| 3| 6| 2| 2| 2| 8| 3| 6| 2| 3| 3| | 6| 5| 9| 9| 6| 8| 0| 9| 9| 9| 0| 6| 5| 8| 0| 3| 9| 9| 9| 2| 0| 3| 2| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Autolysis | | Cyst | X | Nephropathy | 3 3 1 2 2 1 3 2 3 2 2 1 2 1 2 1 2 1 2 4| Pelvis, Epithelium, Hyperplasia | | Renal Tubule, Pigmentation, Bile | 3 4 | Renal Tubule, Regeneration | 1 | __________________________________________________________________________| Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + A + +| _____________________________________________________________________________________________________________________| Page 110 NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97 Route: DOSED FEED Time: 11:13:41 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 5| 2| 7| 2| 7| 7| 2| 6| 7| 7| 2| 7| 2| 7| 7| | | DAY ON TEST | 2| 2| 2| 2| 6| 9| 7| 2| 7| 2| 3| 7| 3| 3| 3| 7| 2| 7| 2| 2| | | | 9| 9| 9| 9| 2| 0| 5| 9| 5| 9| 0| 6| 9| 0| 0| 5| 9| 6| 9| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1000 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 66 | Parasite Metazoan | 3 | 9 2.9| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 69 | Parasite Metazoan | 2 2 X 4 X | 12 3.1| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 63 | Hyperplasia, Lymphoid | | 1 3.0| Parasite Metazoan | | 3 2.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 67 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 65 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 64 | Autolysis | | 1 4.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 70 | Angiectasis, Focal | 3 3 | 5 3.2| Basophilic Focus | X X X X X X X X X X X X | 39 | Clear Cell Focus | X X | 6 | Developmental Malformation | X X X X X | 7 | Eosinophilic Focus | X | 4 | Fatty Change | 3 2 1 | 6 1.7| Granuloma | 3 | 1 3.0| Hepatodiaphragmatic Nodule | X X | 4 | Mixed Cell Focus | | 1 | Necrosis, Focal | | 1 3.0| Bile Duct, Hyperplasia | 2 3 4 | 22 2.6| Lymphatic, Angiectasis, Focal | | 3 2.3| __________________________________________________________________________|____________| Mesentery | + + + + + + | 14 | Accessory Spleen | X | 1 | Fibrosis | | 1 3.0| Artery, Inflammation, Chronic | 4 | 1 4.0| Artery, Thrombosis | X | 1 | Fat, Necro