TDMS Study 05150-01 Pathology Tables
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
Facility: TSI Mason Research
Chemical CAS #: 298-59-9
Lock Date: 02/06/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 2| 7| 7| 4| 7| 4| 7| 7| 7| 2| 6| 7| 7| 2| 6| 7| 6| 5| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 8| 8| 4| 4| 6| 4| 5| 2| 4| 4| 8| 4| 4| 4| 8| 7| 4| 8| 6| 6| 4| 4| 4| 4| 6|
| 2| 2| 8| 6| 3| 8| 0| 9| 8| 8| 1| 8| 8| 8| 2| 7| 8| 0| 3| 4| 8| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X 2 3 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 2 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Dilatation | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X |
Developmental Malformation | |
Fatty Change | 2 |
Granuloma | 3 3 |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | X X X X X |
Necrosis, Focal | |
Pigmentation, Bile | 4 |
Bile Duct, Hyperplasia | 1 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 2 |
Hyperplasia | 2 |
Hypoplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 2 |
Hypoplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 1|
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 2| 7| 7| 4| 7| 4| 7| 7| 7| 2| 6| 7| 7| 2| 6| 7| 6| 5| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 8| 8| 4| 4| 6| 4| 5| 2| 4| 4| 8| 4| 4| 4| 8| 7| 4| 8| 6| 6| 4| 4| 4| 4| 6|
| 2| 2| 8| 6| 3| 8| 0| 9| 8| 8| 1| 8| 8| 8| 2| 7| 8| 0| 3| 4| 8| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 3 2 |
Hyperplasia, Focal | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + M + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hyperplasia, Focal | 2 1 |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + M + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Dilatation | 3 3 |
Inflammation, Acute | |
Inflammation, Chronic, Focal | |
Inflammation, Chronic | 2 1 3 3 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Dilatation | 1 1 |
Endometrium, Cyst | |
Endometrium, Fibrosis | |
Endometrium, Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Vagina | |
Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 2| 7| 7| 4| 7| 4| 7| 7| 7| 2| 6| 7| 7| 2| 6| 7| 6| 5| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 8| 8| 4| 4| 6| 4| 5| 2| 4| 4| 8| 4| 4| 4| 8| 7| 4| 8| 6| 6| 4| 4| 4| 4| 6|
| 2| 2| 8| 6| 3| 8| 0| 9| 8| 8| 1| 8| 8| 8| 2| 7| 8| 0| 3| 4| 8| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 4 4 |
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Congestion | 3 |
Pancreatic, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Giant Cell | |
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | |
Giant Cell | 2 2 2 |
Granuloma | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | |
Depletion Lymphoid | |
Fibrosis, Focal | 3 |
Granuloma | |
Hematopoietic Cell Proliferation | 4 3 |
Infarct | |
Pigmentation, Hemosiderin | |
Capsule, Fibrosis | 3 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Galactocele | X X |
Galactocele, Multiple | X |
Lactation | 2 2 4 3 4 2 2 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
Ectopic Tissue | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 2| 7| 7| 4| 7| 4| 7| 7| 7| 2| 6| 7| 7| 2| 6| 7| 6| 5| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 8| 8| 4| 4| 6| 4| 5| 2| 4| 4| 8| 4| 4| 4| 8| 7| 4| 8| 6| 6| 4| 4| 4| 4| 6|
| 2| 2| 8| 6| 3| 8| 0| 9| 8| 8| 1| 8| 8| 8| 2| 7| 8| 0| 3| 4| 8| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Congestion | |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Necrosis, Focal | |
Alveolar Epithelium, Metaplasia | 2 3 |
Peribronchial, Inflammation, Chronic | 2 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 2 2 1 2 |
Inflammation, Chronic | 3 2 2 2|
Metaplasia, Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 3 |
Mineralization | 2 1 2 2 |
Nephropathy | 2 2 1 2 1 3 2 4 2 2 1 1 2 1 1|
Renal Tubule, Degeneration, Granular | |
Renal Tubule, Necrosis, Focal | 2 |
Renal Tubule, Pigmentation, Bile | 3 3 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 4| 7| 7| 2| 6| 2| 7| 7| 4| 6| 7| 7| 7| 4| 6| 2| 5| 7| 2| 7| 7|
DAY ON TEST | 6| 6| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 6| 6| 2| 4| 4| 6| 6| 8| 5| 4| 6| 4| 4|
| 3| 3| 7| 3| 4| 7| 7| 2| 0| 1| 7| 7| 3| 0| 8| 7| 7| 3| 2| 1| 1| 7| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + A + + + + + + + + + + +|
Autolysis | 3 |
Dilatation | 3 |
Parasite Metazoan | 4 4 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Developmental Malformation | |
Fatty Change | 4 3 2 |
Granuloma | 2 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | |
Necrosis, Focal | |
Pigmentation, Bile | |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Hyperplasia | |
Hypoplasia | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4 |
Hypoplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 3 2 1 2 1 1 3 1 1 3 3 |
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 4| 7| 7| 2| 6| 2| 7| 7| 4| 6| 7| 7| 7| 4| 6| 2| 5| 7| 2| 7| 7|
DAY ON TEST | 6| 6| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 6| 6| 2| 4| 4| 6| 6| 8| 5| 4| 6| 4| 4|
| 3| 3| 7| 3| 4| 7| 7| 2| 0| 1| 7| 7| 3| 0| 8| 7| 7| 3| 2| 1| 1| 7| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
Hyperplasia, Focal | 2 |
Vacuolization Cytoplasmic | 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis, Focal | 2 |
Pars Distalis, Angiectasis | 4 3 4 3 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 2 4 3 3 1 3|
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Dilatation | 3 4 3 3|
Inflammation, Acute | 2 |
Inflammation, Chronic, Focal | 2 2 1 |
Inflammation, Chronic | 1 2 2 1 2 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Dilatation | 3 2 3 |
Endometrium, Cyst | |
Endometrium, Fibrosis | 2 |
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | |
Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 4| 7| 7| 2| 6| 2| 7| 7| 4| 6| 7| 7| 7| 4| 6| 2| 5| 7| 2| 7| 7|
DAY ON TEST | 6| 6| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 6| 6| 2| 4| 4| 6| 6| 8| 5| 4| 6| 4| 4|
| 3| 3| 7| 3| 4| 7| 7| 2| 0| 1| 7| 7| 3| 0| 8| 7| 7| 3| 2| 1| 1| 7| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 4 4 3 |
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Congestion | |
Pancreatic, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Giant Cell | 2 |
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Depletion Lymphoid | 4 |
Giant Cell | 2 1 3 2 |
Granuloma | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | |
Depletion Lymphoid | 3 2 |
Fibrosis, Focal | |
Granuloma | 4 |
Hematopoietic Cell Proliferation | 4 4 |
Infarct | |
Pigmentation, Hemosiderin | 2 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 4 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X X |
Galactocele, Multiple | |
Lactation | 3 2 3 4 3 2 3 2 2 4 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
Ectopic Tissue | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 4| 7| 7| 2| 6| 2| 7| 7| 4| 6| 7| 7| 7| 4| 6| 2| 5| 7| 2| 7| 7|
DAY ON TEST | 6| 6| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 6| 6| 2| 4| 4| 6| 6| 8| 5| 4| 6| 4| 4|
| 3| 3| 7| 3| 4| 7| 7| 2| 0| 1| 7| 7| 3| 0| 8| 7| 7| 3| 2| 1| 1| 7| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 3 |
Congestion | 1 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Necrosis, Focal | 4 3 |
Alveolar Epithelium, Metaplasia | |
Peribronchial, Inflammation, Chronic | 2 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 4 |
Inflammation, Acute | 3 4 |
Inflammation, Chronic, Focal | 2 2 2 |
Inflammation, Chronic | 2 2 1 2 2 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
Mineralization | 1 2 1 2 4 2|
Nephropathy | 2 1 2 2 2 1 3 1 2 4 1 2 1 2 2 3 1|
Renal Tubule, Degeneration, Granular | |
Renal Tubule, Necrosis, Focal | |
Renal Tubule, Pigmentation, Bile | 3 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 5| 2| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| | |
DAY ON TEST | 6| 7| 1| 7| 8| 4| 4| 8| 4| 4| 5| 4| 8| 4| 4| 4| 6| 8| 4| 4| | |
| 4| 5| 3| 5| 2| 7| 7| 4| 7| 7| 0| 9| 2| 7| 7| 7| 8| 1| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + A + + + + + + + + + + + + | 67 |
Parasite Metazoan | 2 3 | 8 2.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + | 69 |
Parasite Metazoan | 3 | 7 2.6|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + A + + + + + + + + + + + + | 66 |
Autolysis | | 1 3.0|
Dilatation | | 1 3.0|
Parasite Metazoan | | 3 3.7|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + A + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + A + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + A + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Abscess | | 2 3.5|
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X X X | 42 |
Clear Cell Focus | X X X X | 11 |
Developmental Malformation | X | 1 |
Fatty Change | 3 3 4 3 | 8 3.0|
Granuloma | | 3 2.7|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 7 |
Necrosis, Focal | 3 | 1 3.0|
Pigmentation, Bile | | 1 4.0|
Bile Duct, Hyperplasia | 1 | 4 1.3|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis | 4 | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Acinus, Atrophy | 3 4 | 13 2.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Cellular | | 2 2.0|
Hyperplasia | | 1 2.0|
Hypoplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia, Squamous | | 2 3.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Erosion | 4 3 | 5 3.2|
Hypoplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 5| 2| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| | |
DAY ON TEST | 6| 7| 1| 7| 8| 4| 4| 8| 4| 4| 5| 4| 8| 4| 4| 4| 6| 8| 4| 4| | |
| 4| 5| 3| 5| 2| 7| 7| 4| 7| 7| 0| 9| 2| 7| 7| 7| 8| 1| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy | 4 2 2 2 3 3 | 25 2.0|
Dilatation | | 1 3.0|
Inflammation, Chronic, Focal | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Cytoplasmic Alteration, Focal | | 3 2.3|
Hyperplasia, Focal | | 1 2.0|
Vacuolization Cytoplasmic | 3 | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia, Focal | 4 2 | 7 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + | 67 |
Hyperplasia, Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemorrhage | | 1 3.0|
Pars Distalis, Angiectasis, Focal | | 1 2.0|
Pars Distalis, Angiectasis | | 5 3.4|
Pars Distalis, Cyst | X X X | 11 |
Pars Distalis, Hyperplasia, Focal | 3 3 4 2 4 3 | 14 2.7|
Pars Distalis, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
C-Cell, Hyperplasia | 2 2 3 | 14 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M M + + + + + + M + + + + + | 65 |
Cyst | X | 4 |
Dilatation | 4 4 4 4 | 10 3.5|
Inflammation, Acute | 2 3 2 | 4 2.3|
Inflammation, Chronic, Focal | 2 2 1 | 6 1.7|
Inflammation, Chronic | 1 | 13 1.6|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 5| 2| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| | |
DAY ON TEST | 6| 7| 1| 7| 8| 4| 4| 8| 4| 4| 5| 4| 8| 4| 4| 4| 6| 8| 4| 4| | |
| 4| 5| 3| 5| 2| 7| 7| 4| 7| 7| 0| 9| 2| 7| 7| 7| 8| 1| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 70 |
Abscess | | 1 4.0|
Dilatation | 3 3 | 7 2.3|
Endometrium, Cyst | X | 1 |
Endometrium, Fibrosis | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Dilatation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 2 3 3 4 4 2 | 17 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 8 |
Mediastinal, Congestion | | 1 3.0|
Pancreatic, Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | | 1 2.0|
Giant Cell | | 1 2.0|
Infiltration Cellular, Plasma Cell | 4 | 1 4.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | 3 4 | 3 3.3|
Depletion Lymphoid | | 1 4.0|
Giant Cell | 4 2 2 | 10 2.2|
Granuloma | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | 3 | 1 3.0|
Congestion | 3 | 1 3.0|
Depletion Lymphoid | 2 2 | 4 2.3|
Fibrosis, Focal | | 1 3.0|
Granuloma | | 1 4.0|
Hematopoietic Cell Proliferation | | 4 3.8|
Infarct | 4 | 1 4.0|
Pigmentation, Hemosiderin | | 1 2.0|
Capsule, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + + + + + + | 68 |
Depletion Lymphoid | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 5| 2| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| | |
DAY ON TEST | 6| 7| 1| 7| 8| 4| 4| 8| 4| 4| 5| 4| 8| 4| 4| 4| 6| 8| 4| 4| | |
| 4| 5| 3| 5| 2| 7| 7| 4| 7| 7| 0| 9| 2| 7| 7| 7| 8| 1| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Galactocele | X X X X | 9 |
Galactocele, Multiple | | 1 |
Lactation | 2 2 2 4 2 4 2 3 3 3 3 4 2 3 3 | 35 2.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperkeratosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperostosis | 2 3 3 4 | 6 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Ectopic Tissue | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Compression | 3 | 4 3.3|
Congestion | | 1 1.0|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Granuloma | 2 | 1 2.0|
Necrosis, Focal | 4 | 3 3.7|
Alveolar Epithelium, Metaplasia | | 2 2.5|
Peribronchial, Inflammation, Chronic | 2 2 2 | 10 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Fungus | 4 | 4 3.8|
Inflammation, Acute | | 2 3.5|
Inflammation, Chronic, Focal | 2 2 2 | 10 1.9|
Inflammation, Chronic | 2 | 10 2.0|
Metaplasia, Squamous | | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 3 |
Retina, Degeneration | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 5| 2| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| | |
DAY ON TEST | 6| 7| 1| 7| 8| 4| 4| 8| 4| 4| 5| 4| 8| 4| 4| 4| 6| 8| 4| 4| | |
| 4| 5| 3| 5| 2| 7| 7| 4| 7| 7| 0| 9| 2| 7| 7| 7| 8| 1| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Mineralization, Focal | | 2 2.5|
Mineralization | 3 3 4 1 3 1 3 3 2 | 19 2.2|
Nephropathy | 1 2 2 1 2 2 3 2 1 1 3 2 3 2 | 46 1.9|
Renal Tubule, Degeneration, Granular | 3 | 1 3.0|
Renal Tubule, Necrosis, Focal | | 1 2.0|
Renal Tubule, Pigmentation, Bile | 2 | 4 2.8|
Renal Tubule, Regeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + A + + + + + + + + + + + + | 67 |
Inflammation, Chronic, Focal | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 2| 2| 4| 7| 4| 7|
DAY ON TEST | 2| 6| 5| 4| 1| 4| 4| 4| 4| 4| 8| 4| 6| 4| 6| 4| 4| 4| 2| 8| 8| 9| 4| 6| 4|
| 1| 3| 0| 3| 2| 3| 3| 3| 4| 3| 5| 3| 0| 3| 4| 1| 4| 4| 8| 1| 2| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + A + + + + + A + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X |
Depletion Glycogen | |
Developmental Malformation | X |
Fatty Change | 1 |
Granuloma | 3 4 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X |
Necrosis, Focal | 4 2|
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Granulomatous | |
Fat, Necrosis | 3 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +|
Ectopic Liver | |
Acinus, Atrophy | 2 2 2 4 4 2 3|
Acinus, Hyperplasia, Focal | 2 |
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperkeratosis | 3 |
Inflammation, Subacute | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + + +|
Depletion Cellular | 3 |
Erosion | 2 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 2| 2| 4| 7| 4| 7|
DAY ON TEST | 2| 6| 5| 4| 1| 4| 4| 4| 4| 4| 8| 4| 6| 4| 6| 4| 4| 4| 2| 8| 8| 9| 4| 6| 4|
| 1| 3| 0| 3| 2| 3| 3| 3| 4| 3| 5| 3| 0| 3| 4| 1| 4| 4| 8| 1| 2| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | |
Pigmentation | 3 |
Coronary Artery, Inflammation, | |
Chronic | 3 |
Myocardium, Inflammation, Chronic, | |
Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + A + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 3 4|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + A + + + + + + + + +|
Fibrosis | |
Hyperplasia, Focal | 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia | 1 |
Hypoplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + M|
Hyperplasia, Focal | |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 3 2 2 2 1 3 3 4|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 2 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Cyst | X |
Depletion Cellular | |
Dilatation | |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 2 2 |
Inflammation, Chronic | 2 1 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 4 3 |
Thrombosis | |
Endometrium, Cyst | X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 2| 2| 4| 7| 4| 7|
DAY ON TEST | 2| 6| 5| 4| 1| 4| 4| 4| 4| 4| 8| 4| 6| 4| 6| 4| 4| 4| 2| 8| 8| 9| 4| 6| 4|
| 1| 3| 0| 3| 2| 3| 3| 3| 4| 3| 5| 3| 0| 3| 4| 1| 4| 4| 8| 1| 2| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Vagina | |
Exudate | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 3 2 4|
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + +|
Mediastinal, Angiectasis | |
Pancreatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X |
Giant Cell | |
Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + A + + + + + + + + +|
Congestion | |
Giant Cell | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
Depletion Lymphoid | 2 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 4 |
Necrosis, Focal | 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Depletion Lymphoid | 2 |
Lymphatic, Angiectasis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X X |
Galactocele, Multiple | |
Lactation | 4 3 3 2 2 3 3 4 4 2 3 4 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X 2 4 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X 4 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 2| 2| 4| 7| 4| 7|
DAY ON TEST | 2| 6| 5| 4| 1| 4| 4| 4| 4| 4| 8| 4| 6| 4| 6| 4| 4| 4| 2| 8| 8| 9| 4| 6| 4|
| 1| 3| 0| 3| 2| 3| 3| 3| 4| 3| 5| 3| 0| 3| 4| 1| 4| 4| 8| 1| 2| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Peribronchial, Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 2 2 |
Inflammation, Chronic | 1 2 2 2 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + A + + +|
Cyst | X |
Glomerulosclerosis | |
Mineralization, Focal | 1 |
Mineralization | 1 1 2 2 3 2 1 2 1 2 3 1 |
Nephropathy | 3 2 1 2 2 2 2 1 2 1 2 3 1 2 1 1 3 1 |
Renal Tubule, Degeneration, Granular | |
Renal Tubule, Pigmentation, Bile | 2 2 3|
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + A + + + + + A + + +|
Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 2| 7| 2| 2| 4| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 4| 7| 4| 4| 7| 6| 7| 2| 7|
DAY ON TEST | 8| 8| 4| 8| 8| 6| 6| 4| 7| 3| 2| 4| 4| 8| 4| 2| 6| 4| 6| 6| 4| 8| 4| 8| 4|
| 2| 1| 4| 2| 1| 4| 3| 4| 1| 2| 9| 3| 4| 2| 4| 0| 4| 4| 4| 4| 4| 1| 7| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 4 4 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | X 2 4|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Depletion Glycogen | 2 |
Developmental Malformation | |
Fatty Change | 3 4 2 |
Granuloma | 1 2 |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | |
Necrosis, Focal | 1 2 2 |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Granulomatous | 2 |
Fat, Necrosis | 4 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Liver | X |
Acinus, Atrophy | 1 2 |
Acinus, Hyperplasia, Focal | |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Subacute | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Erosion | 2 4 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 2| 7| 2| 2| 4| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 4| 7| 4| 4| 7| 6| 7| 2| 7|
DAY ON TEST | 8| 8| 4| 8| 8| 6| 6| 4| 7| 3| 2| 4| 4| 8| 4| 2| 6| 4| 6| 6| 4| 8| 4| 8| 4|
| 2| 1| 4| 2| 1| 4| 3| 4| 1| 2| 9| 3| 4| 2| 4| 0| 4| 4| 4| 4| 4| 1| 7| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 1 1 1 |
Pigmentation | |
Coronary Artery, Inflammation, | |
Chronic | |
Myocardium, Inflammation, Chronic, | |
Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypoplasia | 1 3|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Focal | |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis | 2 3 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia, Focal | 1 3 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 4 4 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Abscess | 2 4 |
Cyst | X X X |
Depletion Cellular | 3 |
Dilatation | 4 |
Inflammation, Acute | 2 3 |
Inflammation, Chronic, Focal | 1 2 1 2 |
Inflammation, Chronic | 2 2 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 4 |
Thrombosis | X |
Endometrium, Cyst | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 2| 7| 2| 2| 4| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 4| 7| 4| 4| 7| 6| 7| 2| 7|
DAY ON TEST | 8| 8| 4| 8| 8| 6| 6| 4| 7| 3| 2| 4| 4| 8| 4| 2| 6| 4| 6| 6| 4| 8| 4| 8| 4|
| 2| 1| 4| 2| 1| 4| 3| 4| 1| 2| 9| 3| 4| 2| 4| 0| 4| 4| 4| 4| 4| 1| 7| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Vagina | + |
Exudate | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 2 |
Myelofibrosis | 1 4 |
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Angiectasis | 3 |
Pancreatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | |
Giant Cell | 2 |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Giant Cell | 4 1 2 1 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 4 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Lymphatic, Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Galactocele, Multiple | |
Lactation | 4 4 4 3 3 3 2 3 4 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 4 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 4 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 2| 7| 2| 2| 4| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 4| 7| 4| 4| 7| 6| 7| 2| 7|
DAY ON TEST | 8| 8| 4| 8| 8| 6| 6| 4| 7| 3| 2| 4| 4| 8| 4| 2| 6| 4| 6| 6| 4| 8| 4| 8| 4|
| 2| 1| 4| 2| 1| 4| 3| 4| 1| 2| 9| 3| 4| 2| 4| 0| 4| 4| 4| 4| 4| 1| 7| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Peribronchial, Inflammation, Chronic | 2 2 1 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 2 2 2 2 2 2 |
Inflammation, Chronic | 3 2 2 2 1 2 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Glomerulosclerosis | |
Mineralization, Focal | 1 1 1 1 |
Mineralization | 1 1 1|
Nephropathy | 2 2 2 3 1 1 2 4 1 3 2 2 2 1 2 3 1|
Renal Tubule, Degeneration, Granular | 2 |
Renal Tubule, Pigmentation, Bile | 2 2 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 7| 7| 7| 5| 7| 6| 7| | |
DAY ON TEST | 4| 6| 8| 4| 4| 4| 1| 4| 1| 6| 8| 8| 4| 4| 4| 4| 7| 4| 9| 1| | |
| 4| 3| 2| 7| 7| 7| 9| 4| 3| 4| 8| 1| 7| 7| 7| 4| 9| 7| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
100 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 67 |
Parasite Metazoan | X 4 2 | 7 2.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + | 67 |
Parasite Metazoan | | 5 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + | 65 |
Parasite Metazoan | | 3 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + A + + + + + + + + A | 63 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + A | 63 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Atrophy | | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X | 48 |
Clear Cell Focus | X | 8 |
Depletion Glycogen | | 1 2.0|
Developmental Malformation | | 1 |
Fatty Change | 4 4 | 6 3.0|
Granuloma | 2 | 5 2.4|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | X X | 3 |
Necrosis, Focal | | 5 2.2|
Bile Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Inflammation, Granulomatous | | 1 2.0|
Fat, Necrosis | | 6 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 |
Ectopic Liver | X | 2 |
Acinus, Atrophy | 2 1 | 11 2.3|
Acinus, Hyperplasia, Focal | | 1 2.0|
Artery, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 68 |
Hyperkeratosis | | 1 3.0|
Inflammation, Subacute | | 1 3.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 69 |
Depletion Cellular | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 7| 7| 7| 5| 7| 6| 7| | |
DAY ON TEST | 4| 6| 8| 4| 4| 4| 1| 4| 1| 6| 8| 8| 4| 4| 4| 4| 7| 4| 9| 1| | |
| 4| 3| 2| 7| 7| 7| 9| 4| 3| 4| 8| 1| 7| 7| 7| 4| 9| 7| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
100 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | 4 2 | 8 2.9|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy | 3 1 4 2 1 2 2 2 | 23 1.9|
Inflammation, Chronic, Focal | 1 1 | 5 1.0|
Pigmentation | | 1 3.0|
Coronary Artery, Inflammation, | | |
Chronic | | 1 3.0|
Myocardium, Inflammation, Chronic, | | |
Focal | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 69 |
Cytoplasmic Alteration, Focal | 3 2 3 | 8 2.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 69 |
Fibrosis | 4 | 1 4.0|
Hyperplasia, Focal | 2 3 | 4 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia | | 1 1.0|
Hypoplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 66 |
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Hemorrhage | 4 | 1 4.0|
Pars Distalis, Angiectasis | | 3 2.3|
Pars Distalis, Cyst | X X X | 7 |
Pars Distalis, Hyperplasia, Focal | 4 2 1 | 16 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
C-Cell, Hyperplasia | 1 2 | 12 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + | 68 |
Abscess | 3 | 4 2.8|
Cyst | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 7| 7| 7| 5| 7| 6| 7| | |
DAY ON TEST | 4| 6| 8| 4| 4| 4| 1| 4| 1| 6| 8| 8| 4| 4| 4| 4| 7| 4| 9| 1| | |
| 4| 3| 2| 7| 7| 7| 9| 4| 3| 4| 8| 1| 7| 7| 7| 4| 9| 7| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
100 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Depletion Cellular | 2 | 2 2.5|
Dilatation | 4 3 3 | 4 3.5|
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic, Focal | 2 2 | 8 1.8|
Inflammation, Chronic | 3 | 8 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 70 |
Dilatation | 3 | 6 3.0|
Thrombosis | X | 2 |
Endometrium, Cyst | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
Exudate | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 4 2 3 | 11 3.0|
Myelofibrosis | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
Mediastinal, Angiectasis | | 1 3.0|
Pancreatic, Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | | 1 3.0|
Cyst | | 1 |
Giant Cell | | 1 2.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 69 |
Congestion | 3 | 1 3.0|
Giant Cell | 2 2 | 10 2.2|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 69 |
Depletion Lymphoid | | 1 2.0|
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | | 2 4.0|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + | 68 |
Depletion Lymphoid | 4 | 2 3.0|
Lymphatic, Angiectasis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 7| 7| 7| 5| 7| 6| 7| | |
DAY ON TEST | 4| 6| 8| 4| 4| 4| 1| 4| 1| 6| 8| 8| 4| 4| 4| 4| 7| 4| 9| 1| | |
| 4| 3| 2| 7| 7| 7| 9| 4| 3| 4| 8| 1| 7| 7| 7| 4| 9| 7| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
100 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Galactocele | X X | 5 |
Galactocele, Multiple | X | 1 |
Lactation | 2 3 4 2 3 3 3 2 2 2 4 2 | 36 2.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Acanthosis | | 1 3.0|
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperostosis | 4 3 3 3 | 9 3.1|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Compression | 2 | 6 3.3|
Hemorrhage | 4 1 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 2 2.0|
Peribronchial, Inflammation, Chronic | 2 1 | 10 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Fungus | 4 2 3 | 4 2.8|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic, Focal | 2 2 | 10 2.0|
Inflammation, Chronic | 2 2 | 12 1.9|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 69 |
Cyst | | 1 |
Glomerulosclerosis | 4 2 | 2 3.0|
Mineralization, Focal | | 5 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 7| 7| 7| 5| 7| 6| 7| | |
DAY ON TEST | 4| 6| 8| 4| 4| 4| 1| 4| 1| 6| 8| 8| 4| 4| 4| 4| 7| 4| 9| 1| | |
| 4| 3| 2| 7| 7| 7| 9| 4| 3| 4| 8| 1| 7| 7| 7| 4| 9| 7| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
100 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Mineralization | 1 2 3 2 1 1 1 | 22 1.6|
Nephropathy | 2 2 1 3 2 1 2 1 2 3 1 1 3 1 | 49 1.9|
Renal Tubule, Degeneration, Granular | | 1 2.0|
Renal Tubule, Pigmentation, Bile | 4 | 6 2.5|
Renal Tubule, Regeneration | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + A + + + + + + + + + | 64 |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 6| 2| 4| 7| 4| 2| 5| 7| 7| 4| 4| 7| 7| 2| 4| 2| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 8| 6| 4| 6| 8| 6| 4| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 8| 4| 4| 4| 4| 4|
| 5| 5| 1| 3| 2| 3| 1| 7| 2| 2| 3| 4| 2| 2| 2| 4| 1| 2| 2| 8| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Angiectasis | 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Eosinophilic Focus | |
Fatty Change | |
Granuloma | 1 1 2 |
Hepatodiaphragmatic Nodule | |
Bile Duct, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis | 4 4 2 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 4 2 3 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Erosion | |
Ulcer | 4 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 1 2 1 2|
Inflammation, Chronic, Focal | 1 |
Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 6| 2| 4| 7| 4| 2| 5| 7| 7| 4| 4| 7| 7| 2| 4| 2| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 8| 6| 4| 6| 8| 6| 4| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 8| 4| 4| 4| 4| 4|
| 5| 5| 1| 3| 2| 3| 1| 7| 2| 2| 3| 4| 2| 2| 2| 4| 1| 2| 2| 8| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cytoplasmic Alteration, Focal | 2 4 4 |
Hyperplasia, Focal | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X X X X X |
Pars Distalis, Hyperplasia, Focal | 2 4 2 4 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 4 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Dilatation | 3 |
Inflammation, Acute | 3 2 |
Inflammation, Chronic, Focal | 1 2 2 |
Inflammation, Chronic | 2 2 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Dilatation | 2 3 3 2 2 |
Thrombosis | |
Endometrium, Fibrosis | |
Endometrium, Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Vagina | + + |
Dilatation | 3 |
Exudate | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Hypochromasia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 4 3 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 6| 2| 4| 7| 4| 2| 5| 7| 7| 4| 4| 7| 7| 2| 4| 2| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 8| 6| 4| 6| 8| 6| 4| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 8| 4| 4| 4| 4| 4|
| 5| 5| 1| 3| 2| 3| 1| 7| 2| 2| 3| 4| 2| 2| 2| 4| 1| 2| 2| 8| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + |
Lumbar, Hyperplasia | |
Mediastinal, Angiectasis | |
Mediastinal, Congestion | 3 |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Lymphatic, Angiectasis | |
Pancreatic, Granuloma | |
Pancreatic, Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Giant Cell | 2 |
Infiltration Cellular, Plasma Cell | 4 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Giant Cell | 3 2 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 2 |
Fibrosis, Focal | |
Granuloma | |
Hematopoietic Cell Proliferation | 4 |
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 4 |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Lactation | 3 4 2 2 2 3 4 3 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperkeratosis | |
Perivascular, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 4 X |
__________________________________________________________________________|
Skeletal Muscle | + |
Ectopic Tissue | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 6| 2| 4| 7| 4| 2| 5| 7| 7| 4| 4| 7| 7| 2| 4| 2| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 8| 6| 4| 6| 8| 6| 4| 4| 6| 6| 4| 4| 8| 6| 8| 4| 4| 8| 4| 4| 4| 4| 4|
| 5| 5| 1| 3| 2| 3| 1| 7| 2| 2| 3| 4| 2| 2| 2| 4| 1| 2| 2| 8| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage | 3 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Congestion | |
Emphysema, Focal | |
Hemorrhage, Focal | |
Alveolar Epithelium, Metaplasia | |
Peribronchial, Inflammation, Chronic | 2 2 2 2 |
Pleura, Fibrosis, Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | 2|
Inflammation, Chronic, Focal | 2 2 2 2 |
Inflammation, Chronic | 3 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +|
Cyst | |
Mineralization, Focal | 1 |
Mineralization | 2 2 2 2 2 2 2 2 |
Nephropathy | 2 1 1 2 2 2 1 2 1 2 1 2 2 2 2|
Renal Tubule, Degeneration, Granular | |
Renal Tubule, Pigmentation, Bile | |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 2| 2| 4| 7| 6| 2| 7| 7| 7| 7| 4| 7| 2| 5| 7| 6| 7| 7| 7| 5| 2|
DAY ON TEST | 4| 3| 6| 4| 8| 8| 6| 4| 7| 8| 4| 4| 4| 4| 6| 4| 8| 4| 4| 3| 4| 3| 4| 8| 8|
| 2| 0| 3| 2| 8| 1| 6| 2| 5| 2| 2| 2| 2| 2| 4| 3| 2| 6| 3| 8| 3| 0| 3| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
Parasite Metazoan | X 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + A + + + + + + + + + + + + + + + + A +|
Parasite Metazoan | X|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Angiectasis | 3 2 |
Basophilic Focus | X X X X X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Fatty Change | 2 4 2 |
Granuloma | 1 2 2 1 |
Hepatodiaphragmatic Nodule | X X |
Bile Duct, Hyperplasia | 1 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 2 2 3 1 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Erosion | 3 3 2 |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 3 2 |
Inflammation, Chronic, Focal | 1 1 1 |
Artery, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 2| 2| 4| 7| 6| 2| 7| 7| 7| 7| 4| 7| 2| 5| 7| 6| 7| 7| 7| 5| 2|
DAY ON TEST | 4| 3| 6| 4| 8| 8| 6| 4| 7| 8| 4| 4| 4| 4| 6| 4| 8| 4| 4| 3| 4| 3| 4| 8| 8|
| 2| 0| 3| 2| 8| 1| 6| 2| 5| 2| 2| 2| 2| 2| 4| 3| 2| 6| 3| 8| 3| 0| 3| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cytoplasmic Alteration, Focal | 3 3 2 2 2 |
Hyperplasia, Focal | 4 |
Vacuolization Cytoplasmic | 4 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 1 4 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | |
Dilatation | 3 |
Inflammation, Acute | 2 |
Inflammation, Chronic, Focal | 2 2 2 1|
Inflammation, Chronic | 3 2 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 2 |
Dilatation | 3 4 3 3 |
Thrombosis | |
Endometrium, Fibrosis | 4 |
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | + |
Dilatation | |
Exudate | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Hypochromasia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 3 2 2 3 3 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 2| 2| 4| 7| 6| 2| 7| 7| 7| 7| 4| 7| 2| 5| 7| 6| 7| 7| 7| 5| 2|
DAY ON TEST | 4| 3| 6| 4| 8| 8| 6| 4| 7| 8| 4| 4| 4| 4| 6| 4| 8| 4| 4| 3| 4| 3| 4| 8| 8|
| 2| 0| 3| 2| 8| 1| 6| 2| 5| 2| 2| 2| 2| 2| 4| 3| 2| 6| 3| 8| 3| 0| 3| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Lumbar, Hyperplasia | 2 |
Mediastinal, Angiectasis | |
Mediastinal, Congestion | |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Lymphatic, Angiectasis | 4 |
Pancreatic, Granuloma | |
Pancreatic, Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Giant Cell | |
Infiltration Cellular, Plasma Cell | |
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
Congestion | 4 4 |
Giant Cell | 2 3 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Fibrosis, Focal | 3 |
Granuloma | |
Hematopoietic Cell Proliferation | 4 3 4 |
Infarct | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + M M + + + + + + +|
Galactocele | |
Lactation | 1 2 3 2 3 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + M + + + + + + + +|
Fibrosis | 4 |
Hyperkeratosis | 4 |
Perivascular, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 4 2 3 2 2 2 |
__________________________________________________________________________|
Skeletal Muscle | |
Ectopic Tissue | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 2| 2| 4| 7| 6| 2| 7| 7| 7| 7| 4| 7| 2| 5| 7| 6| 7| 7| 7| 5| 2|
DAY ON TEST | 4| 3| 6| 4| 8| 8| 6| 4| 7| 8| 4| 4| 4| 4| 6| 4| 8| 4| 4| 3| 4| 3| 4| 8| 8|
| 2| 0| 3| 2| 8| 1| 6| 2| 5| 2| 2| 2| 2| 2| 4| 3| 2| 6| 3| 8| 3| 0| 3| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + M + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage | 1 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 3 |
Emphysema, Focal | 2 |
Hemorrhage, Focal | 3 |
Alveolar Epithelium, Metaplasia | 3 |
Peribronchial, Inflammation, Chronic | 2 1 2 1|
Pleura, Fibrosis, Focal | |
__________________________________________________________________________|
Nose | + + + + + M + + + + + + + + + + + + + + + + + + +|
Fungus | 4 4 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic, Focal | 2 2 2|
Inflammation, Chronic | 2 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization, Focal | 1 1 1 1|
Mineralization | 2 1 1 2 1 1 1 4 |
Nephropathy | 1 1 2 2 2 2 2 2 2 2 1 1 1 |
Renal Tubule, Degeneration, Granular | 4 |
Renal Tubule, Pigmentation, Bile | 3 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 2| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 2| 6| | |
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 8| 6| 4| 4| 4| 4| 3| 4| 4| 4| 4| 8| 4| | |
| 2| 4| 2| 2| 4| 3| 3| 2| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 69 |
Parasite Metazoan | 3 4 2 2 | 7 2.8|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 |
Parasite Metazoan | 4 2 | 4 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 69 |
Parasite Metazoan | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 67 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis, Focal | | 1 2.0|
Angiectasis | | 4 2.3|
Basophilic Focus | X X X X X X X X X X X X X X | 41 |
Clear Cell Focus | X X X | 4 |
Eosinophilic Focus | | 1 |
Fatty Change | 2 3 | 5 2.6|
Granuloma | | 7 1.4|
Hepatodiaphragmatic Nodule | X X X | 5 |
Bile Duct, Hyperplasia | | 5 1.2|
__________________________________________________________________________|____________|
Mesentery | + | 9 |
Fat, Necrosis | 3 | 8 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Acinus, Atrophy | 2 3 4 | 18 2.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Cellular | 2 | 1 2.0|
Erosion | | 3 2.7|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy | 2 2 1 1 4 1 1 3 1 2 | 24 1.9|
Inflammation, Chronic, Focal | 1 1 | 6 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 2| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 2| 6| | |
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 8| 6| 4| 4| 4| 4| 3| 4| 4| 4| 4| 8| 4| | |
| 2| 4| 2| 2| 4| 3| 3| 2| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Artery, Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | | 1 4.0|
Cytoplasmic Alteration, Focal | | 8 2.8|
Hyperplasia, Focal | 2 3 | 3 3.0|
Vacuolization Cytoplasmic | | 2 3.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia, Focal | | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
Hypoplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + M + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Pars Distalis, Angiectasis | | 2 3.0|
Pars Distalis, Cyst | X X | 7 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 | 12 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
C-Cell, Hyperplasia | 1 1 3 | 14 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Cyst | X | 1 |
Dilatation | 3 3 3 | 5 3.0|
Inflammation, Acute | | 3 2.3|
Inflammation, Chronic, Focal | 2 1 | 9 1.7|
Inflammation, Chronic | 2 2 3 | 11 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 1 2.0|
Cyst | | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | 3 | 1 3.0|
Atrophy | | 1 2.0|
Dilatation | 2 | 10 2.7|
Thrombosis | X | 1 |
Endometrium, Fibrosis | 2 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 2| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 2| 6| | |
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 8| 6| 4| 4| 4| 4| 3| 4| 4| 4| 4| 8| 4| | |
| 2| 4| 2| 2| 4| 3| 3| 2| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Hyperplasia, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + | 4 |
Dilatation | | 1 3.0|
Exudate | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Hypochromasia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 4 3 | 15 3.0|
Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 12 |
Lumbar, Hyperplasia | | 1 2.0|
Mediastinal, Angiectasis | 3 | 1 3.0|
Mediastinal, Congestion | 4 | 2 3.5|
Mediastinal, Hematopoietic Cell | | |
Proliferation | 4 | 1 4.0|
Mediastinal, Lymphatic, Angiectasis | | 1 4.0|
Pancreatic, Granuloma | 4 | 1 4.0|
Pancreatic, Lymphatic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | | 1 4.0|
Giant Cell | | 1 2.0|
Infiltration Cellular, Plasma Cell | | 1 4.0|
Lymphatic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + | 68 |
Congestion | | 3 3.7|
Giant Cell | 3 | 8 2.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Lymphoid | 2 3 2 | 6 2.2|
Fibrosis, Focal | 2 4 | 3 3.0|
Granuloma | 4 | 1 4.0|
Hematopoietic Cell Proliferation | | 4 3.8|
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Lymphoid | | 1 4.0|
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 2| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 2| 6| | |
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 8| 6| 4| 4| 4| 4| 3| 4| 4| 4| 4| 8| 4| | |
| 2| 4| 2| 2| 4| 3| 3| 2| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 66 |
Galactocele | X X | 2 |
Lactation | 2 2 3 2 3 2 3 2 3 3 4 | 27 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 69 |
Fibrosis | | 1 4.0|
Hyperkeratosis | | 1 4.0|
Perivascular, Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperostosis | 2 4 | 12 2.8|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Ectopic Tissue | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 69 |
Compression | 2 | 4 2.0|
Hemorrhage | | 2 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 2 1.5|
Congestion | | 1 3.0|
Emphysema, Focal | | 1 2.0|
Hemorrhage, Focal | | 1 3.0|
Alveolar Epithelium, Metaplasia | | 1 3.0|
Peribronchial, Inflammation, Chronic | 2 | 9 1.8|
Pleura, Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 69 |
Fungus | 2 | 3 3.3|
Inflammation, Acute | 3 2 | 5 2.2|
Inflammation, Chronic, Focal | 2 2 | 9 2.0|
Inflammation, Chronic | 2 4 2 3 2 | 16 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 2| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 2| 6| | |
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 8| 6| 4| 4| 4| 4| 3| 4| 4| 4| 4| 8| 4| | |
| 2| 4| 2| 2| 4| 3| 3| 2| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 68 |
Cyst | X | 1 |
Mineralization, Focal | 1 1 | 7 1.0|
Mineralization | 2 2 1 2 | 20 1.8|
Nephropathy | 3 2 2 1 2 2 1 2 1 2 2 | 39 1.7|
Renal Tubule, Degeneration, Granular | | 1 4.0|
Renal Tubule, Pigmentation, Bile | | 1 3.0|
Renal Tubule, Regeneration | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 2| 4| 4| 7| 2| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 6| 8| 6| 0| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 3| 3| 3| 3| 6| 6| 4| 3| 4|
| 3| 2| 3| 4| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 3| 3| 7| 7| 7| 7| 4| 4| 1| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 4 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Parasite Metazoan | 2 2 3 3 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Fatty Change | 3 1 2 1 |
Granuloma | 3 2 2 2 |
Hepatodiaphragmatic Nodule | X X |
Hepatodiaphragmatic Nodule, Multiple | |
Mineralization, Focal | |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + |
Accessory Spleen | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Acinus, Atrophy | 2 2 2 3 3|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Diverticulum | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Edema, Focal | |
Erosion | 4 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 2 2 3 2 4|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 2| 4| 4| 7| 2| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 6| 8| 6| 0| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 3| 3| 3| 3| 6| 6| 4| 3| 4|
| 3| 2| 3| 4| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 3| 3| 7| 7| 7| 7| 4| 4| 1| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 1 |
Mineralization | |
Myocardium, Inflammation, Chronic, | |
Focal | 1 |
Perivascular, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cytoplasmic Alteration, Focal | 2 |
Mineralization, Focal | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 2 |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M M M + + + + + + + + M + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia, Focal | 3 1 3 3 2 2 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
C-Cell, Hyperplasia | 3 2 1 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Dilatation | 3 3 3 2 |
Inflammation, Acute | 3 2 |
Inflammation, Chronic, Focal | 2 3 |
Inflammation, Chronic | 1 2 2 2 2 1 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 2| 4| 4| 7| 2| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 6| 8| 6| 0| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 3| 3| 3| 3| 6| 6| 4| 3| 4|
| 3| 2| 3| 4| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 3| 3| 7| 7| 7| 7| 4| 4| 1| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X |
Dilatation | 3 3 |
Endometrium, Cyst | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Bacterium | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + |
Inguinal, Congestion | |
Lumbar, Congestion | |
Mediastinal, Congestion | |
Pancreatic, Angiectasis | |
Pancreatic, Giant Cell | 3 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Pigmentation, Hemosiderin| 2 |
Pancreatic, Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Plasma Cell | 3 |
Infiltration Cellular, Histiocyte | |
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | |
Giant Cell | 2 1 |
Granuloma | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 2 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 4 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
Cyst | X X X |
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Lactation | 3 2 4 2 3 2 3 4 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 2| 4| 4| 7| 2| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 6| 8| 6| 0| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 3| 3| 3| 3| 6| 6| 4| 3| 4|
| 3| 2| 3| 4| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 3| 3| 7| 7| 7| 7| 4| 4| 1| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Compression | 4 |
Hemorrhage | 2 |
Capillary, Inflammation, Chronic | 2 |
Choroid Plexus, Inflammation, Chronic| 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
Alveolar Epithelium, Metaplasia | |
Peribronchial, Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 |
Inflammation, Acute | 3 2 3 |
Inflammation, Chronic, Focal | 3 2 |
Inflammation, Chronic | 1 1 2 2 3 3 2 2 2 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Bacterium | |
Cyst | |
Glomerulosclerosis | |
Mineralization | 1 1 1 1 2 2 1 |
Nephropathy | 1 2 1 2 1 2 1 1 1 1 1 1 2 4 |
Pigmentation | |
Renal Tubule, Pigmentation, Bile | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 2| 4| 4| 7| 2| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 6| 8| 6| 0| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 3| 3| 3| 3| 6| 6| 4| 3| 4|
| 3| 2| 3| 4| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 3| 3| 7| 7| 7| 7| 4| 4| 1| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 4| 2| 5| 2| 7| 6| 2| 7| 7| 2| 7| 2| 2| 4| 7| 5| 2| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 6| 6| 8| 9| 8| 4| 5| 8| 4| 4| 8| 4| 8| 8| 6| 3| 5| 8| 4|
| 1| 1| 1| 1| 1| 2| 3| 3| 1| 1| 2| 2| 8| 2| 2| 2| 1| 1| 2| 2| 4| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 X 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Parasite Metazoan | 3 3 X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 |
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X|
Fatty Change | 1 1 |
Granuloma | 3 1 2|
Hepatodiaphragmatic Nodule | X X |
Hepatodiaphragmatic Nodule, Multiple | |
Mineralization, Focal | |
Necrosis, Focal | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + |
Accessory Spleen | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 |
Acinus, Atrophy | 3 3 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Diverticulum | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2|
Edema, Focal | |
Erosion | 4 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 2 1 1 3 2 2|
Dilatation | 2 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 4| 2| 5| 2| 7| 6| 2| 7| 7| 2| 7| 2| 2| 4| 7| 5| 2| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 6| 6| 8| 9| 8| 4| 5| 8| 4| 4| 8| 4| 8| 8| 6| 3| 5| 8| 4|
| 1| 1| 1| 1| 1| 2| 3| 3| 1| 1| 2| 2| 8| 2| 2| 2| 1| 1| 2| 2| 4| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 1 1 1 |
Mineralization | |
Myocardium, Inflammation, Chronic, | |
Focal | |
Perivascular, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cytoplasmic Alteration, Focal | 2 |
Mineralization, Focal | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 1 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Cyst | X X X X X |
Pars Distalis, Hyperplasia, Focal | 2 1 |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
C-Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Dilatation | 3 3 2 3 |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 2 2 2 2 1 |
Inflammation, Chronic | 2 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 3 |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 4| 2| 5| 2| 7| 6| 2| 7| 7| 2| 7| 2| 2| 4| 7| 5| 2| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 6| 6| 8| 9| 8| 4| 5| 8| 4| 4| 8| 4| 8| 8| 6| 3| 5| 8| 4|
| 1| 1| 1| 1| 1| 2| 3| 3| 1| 1| 2| 2| 8| 2| 2| 2| 1| 1| 2| 2| 4| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X |
Dilatation | 3 3 3 4 |
Endometrium, Cyst | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Bacterium | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 3 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Inguinal, Congestion | 4 |
Lumbar, Congestion | 3 |
Mediastinal, Congestion | 4 |
Pancreatic, Angiectasis | 4 |
Pancreatic, Giant Cell | 4 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 3 |
Pancreatic, Pigmentation, Hemosiderin| 2 |
Pancreatic, Lymphatic, Angiectasis | 3 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Congestion | 2 2 3 |
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Histiocyte | |
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 3 |
Depletion Lymphoid | |
Giant Cell | 2 2 2 3 2 1 2 |
Granuloma | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 1 3 2 2|
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + M + I + + + + + + + + + + + + + + M + + +|
Cyst | |
Depletion Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
Lactation | 2 2 2 3 3 3 2 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 4| 2| 5| 2| 7| 6| 2| 7| 7| 2| 7| 2| 2| 4| 7| 5| 2| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 6| 6| 8| 9| 8| 4| 5| 8| 4| 4| 8| 4| 8| 8| 6| 3| 5| 8| 4|
| 1| 1| 1| 1| 1| 2| 3| 3| 1| 1| 2| 2| 8| 2| 2| 2| 1| 1| 2| 2| 4| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 2 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Compression | 4 2 3 |
Hemorrhage | 2 4 |
Capillary, Inflammation, Chronic | |
Choroid Plexus, Inflammation, Chronic| |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
Alveolar Epithelium, Metaplasia | |
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 4 |
Inflammation, Acute | 2 3 2 2 |
Inflammation, Chronic, Focal | 2 2 2 2 2 |
Inflammation, Chronic | 2 2 2 |
Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Bacterium | |
Cyst | X |
Glomerulosclerosis | 4 |
Mineralization | 1 1 2 |
Nephropathy | 1 2 1 2 1 1 2 2 2 2 1 1 2 2|
Pigmentation | 3 |
Renal Tubule, Pigmentation, Bile | 3 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 4| 2| 5| 2| 7| 6| 2| 7| 7| 2| 7| 2| 2| 4| 7| 5| 2| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 6| 6| 8| 9| 8| 4| 5| 8| 4| 4| 8| 4| 8| 8| 6| 3| 5| 8| 4|
| 1| 1| 1| 1| 1| 2| 3| 3| 1| 1| 2| 2| 8| 2| 2| 2| 1| 1| 2| 2| 4| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 2| 6| 7| 7| 7| | |
DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 3| 4| 1| 3| 4| 4| 7| 4| 8| 6| 4| 4| 4| | |
| 1| 4| 9| 2| 2| 1| 2| 0| 1| 4| 7| 1| 1| 6| 1| 1| 9| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + + + + + + + + + + + + + + | 69 |
Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + | 69 |
Parasite Metazoan | 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 |
Parasite Metazoan | | 6 3.4|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + A + + + + + + + + + + | 68 |
Inflammation, Chronic | | 1 2.0|
Parasite Metazoan | | 8 2.7|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + A + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + A + + + + + + + + + + | 68 |
Abscess | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 4 2.5|
Basophilic Focus | X X X X X X X X X X X X X | 48 |
Clear Cell Focus | X X | 10 |
Fatty Change | 1 | 7 1.4|
Granuloma | 2 | 8 2.1|
Hepatodiaphragmatic Nodule | X X | 6 |
Hepatodiaphragmatic Nodule, Multiple | X | 1 |
Mineralization, Focal | 3 | 1 3.0|
Necrosis, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Accessory Spleen | X | 1 |
Fat, Necrosis | | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | | 2 2.0|
Acinus, Atrophy | 2 4 2 4 | 13 2.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Acanthosis | 3 | 1 3.0|
Diverticulum | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Cellular | | 1 2.0|
Edema, Focal | 2 | 1 2.0|
Erosion | 2 4 4 | 5 3.6|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 2| 6| 7| 7| 7| | |
DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 3| 4| 1| 3| 4| 4| 7| 4| 8| 6| 4| 4| 4| | |
| 1| 4| 9| 2| 2| 1| 2| 0| 1| 4| 7| 1| 1| 6| 1| 1| 9| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy | 2 3 2 3 4 2 2 2 | 26 2.2|
Dilatation | | 1 2.0|
Inflammation, Chronic, Focal | | 4 1.0|
Mineralization | 1 | 1 1.0|
Myocardium, Inflammation, Chronic, | | |
Focal | | 1 1.0|
Perivascular, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 69 |
Atrophy | | 1 2.0|
Cytoplasmic Alteration, Focal | 2 | 3 2.0|
Mineralization, Focal | 3 | 1 3.0|
Vacuolization Cytoplasmic | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia, Focal | | 2 2.5|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
Hypoplasia | | 4 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + M + + + + | 61 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + | 67 |
Pars Distalis, Angiectasis | | 2 3.0|
Pars Distalis, Cyst | | 8 |
Pars Distalis, Hyperplasia, Focal | 2 3 3 | 11 2.3|
Pars Distalis, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | | 1 1.0|
C-Cell, Hyperplasia | 1 1 1 | 12 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + + + | 69 |
Cyst | | 3 |
Dilatation | 3 | 9 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 2| 6| 7| 7| 7| | |
DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 3| 4| 1| 3| 4| 4| 7| 4| 8| 6| 4| 4| 4| | |
| 1| 4| 9| 2| 2| 1| 2| 0| 1| 4| 7| 1| 1| 6| 1| 1| 9| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic, Focal | 2 | 8 2.0|
Inflammation, Chronic | 2 | 11 1.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 1 3.0|
Atrophy | | 1 3.0|
Cyst | X X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 1 3.0|
Atrophy | | 2 2.5|
Cyst | | 2 |
Dilatation | | 6 3.2|
Endometrium, Cyst | X | 1 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Bacterium | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 3 2 4 3 3 | 12 2.5|
Myelofibrosis | 4 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 8 |
Inguinal, Congestion | | 1 4.0|
Lumbar, Congestion | | 1 3.0|
Mediastinal, Congestion | | 1 4.0|
Pancreatic, Angiectasis | | 1 4.0|
Pancreatic, Giant Cell | | 2 3.5|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Pancreatic, Pigmentation, Hemosiderin| | 2 2.0|
Pancreatic, Lymphatic, Angiectasis | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 69 |
Congestion | | 3 2.3|
Infiltration Cellular, Plasma Cell | | 1 3.0|
Infiltration Cellular, Histiocyte | 4 | 1 4.0|
Lymphatic, Angiectasis | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | 3 4 | 4 3.5|
Depletion Lymphoid | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 2| 6| 7| 7| 7| | |
DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 3| 4| 1| 3| 4| 4| 7| 4| 8| 6| 4| 4| 4| | |
| 1| 4| 9| 2| 2| 1| 2| 0| 1| 4| 7| 1| 1| 6| 1| 1| 9| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Giant Cell | 1 | 10 1.8|
Granuloma | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Lymphoid | 1 2 | 9 2.0|
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 3 3.0|
Capsule, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + + | 65 |
Cyst | | 3 |
Depletion Lymphoid | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Galactocele | | 1 |
Lactation | 2 2 3 2 3 2 2 2 2 | 25 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperostosis | 3 3 3 | 8 3.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Abscess | 2 | 1 2.0|
Compression | | 4 3.3|
Hemorrhage | 4 | 4 3.0|
Capillary, Inflammation, Chronic | 2 | 2 2.0|
Choroid Plexus, Inflammation, Chronic| | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Mineralization, Focal | 4 | 1 4.0|
Alveolar Epithelium, Metaplasia | 4 | 1 4.0|
Peribronchial, Inflammation, Chronic | 2 | 10 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Fungus | | 3 3.7|
Inflammation, Acute | 2 3 2 | 10 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 2| 6| 7| 7| 7| | |
DAY ON TEST | 4| 6| 1| 4| 4| 4| 4| 3| 4| 1| 3| 4| 4| 7| 4| 8| 6| 4| 4| 4| | |
| 1| 4| 9| 2| 2| 1| 2| 0| 1| 4| 7| 1| 1| 6| 1| 1| 9| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1000 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | 2 | 8 2.1|
Inflammation, Chronic | 3 3 | 14 2.1|
Metaplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Cataract | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + + + + + + + + + + + | 69 |
Abscess | 3 | 1 3.0|
Bacterium | X | 1 |
Cyst | | 1 |
Glomerulosclerosis | | 1 4.0|
Mineralization | 2 1 1 2 1 1 1 1 2 1 | 20 1.3|
Nephropathy | 1 1 2 2 1 1 1 1 1 1 1 2 | 40 1.5|
Pigmentation | | 1 3.0|
Renal Tubule, Pigmentation, Bile | 2 | 2 2.5|
Renal Tubule, Regeneration | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + | 68 |
Hemorrhage | 4 | 2 4.0|
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 6| 6| 4| 7| 5| 4| 7| 2| 7| 6| 7| 5| 7| 7| 7| 4| 2| 2| 2| 3| 4| 6| 7| 7|
DAY ON TEST | 5| 3| 3| 6| 3| 2| 6| 3| 7| 3| 9| 1| 6| 1| 3| 3| 6| 7| 7| 7| 0| 6| 3| 3| 3|
| 9| 2| 2| 3| 6| 4| 2| 6| 6| 6| 5| 5| 6| 7| 6| 6| 2| 6| 6| 5| 4| 3| 9| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | 2 X 4 4 X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | 2 3 X 4 X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Edema | 4 |
Parasite Metazoan | 2 X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + A + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 4 |
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Cyst | |
Developmental Malformation | X|
Eosinophilic Focus | |
Fatty Change | 2 2 4 |
Fibrosis, Focal | 3 |
Hepatodiaphragmatic Nodule | |
Necrosis, Focal | 2 |
Proliferation | 3 |
Bile Duct, Hyperplasia | 2 3 4 2 4|
Lymphatic, Angiectasis, Focal | |
__________________________________________________________________________|
Mesentery | + + + |
Accessory Spleen | |
Fat, Hemorrhage | 4 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 3 2 4 2 1 3|
Acinus, Hyperplasia, Focal | |
Vein, Thrombosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Thrombosis | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3|
Ulcer | 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4 1 |
Hyperplasia, Lymphoid | |
Mucosa, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 6| 6| 4| 7| 5| 4| 7| 2| 7| 6| 7| 5| 7| 7| 7| 4| 2| 2| 2| 3| 4| 6| 7| 7|
DAY ON TEST | 5| 3| 3| 6| 3| 2| 6| 3| 7| 3| 9| 1| 6| 1| 3| 3| 6| 7| 7| 7| 0| 6| 3| 3| 3|
| 9| 2| 2| 3| 6| 4| 2| 6| 6| 6| 5| 5| 6| 7| 6| 6| 2| 6| 6| 5| 4| 3| 9| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 1 2 4 4 1 2 2 2 3 2 4 2 2 3 2 3|
Inflammation, Chronic, Focal | 1 2 |
Mineralization | 2 |
Artery, Inflammation, Chronic | |
Atrium, Dilatation | 4 |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Cytoplasmic Alteration | 2 |
Hypertrophy | 3 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia, Focal | 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Thymus | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 3 3 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 3 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X |
Ectasia | |
Hyperplasia | |
Inflammation, Chronic, Focal | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 6| 6| 4| 7| 5| 4| 7| 2| 7| 6| 7| 5| 7| 7| 7| 4| 2| 2| 2| 3| 4| 6| 7| 7|
DAY ON TEST | 5| 3| 3| 6| 3| 2| 6| 3| 7| 3| 9| 1| 6| 1| 3| 3| 6| 7| 7| 7| 0| 6| 3| 3| 3|
| 9| 2| 2| 3| 6| 4| 2| 6| 6| 6| 5| 5| 6| 7| 6| 6| 2| 6| 6| 5| 4| 3| 9| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 1 1 2 3 2 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 3 3 3 2 2 |
Dilatation | |
Inflammation, Acute | 3 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 3 4 4 4 4 4 3 4 4 4|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | 3 3 |
Interstitial Cell, Hyperplasia | 3 |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 4 3 3 4 4 4|
Myelofibrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Congestion | 3 |
Mediastinal, Lymphatic, Angiectasis | 3 |
Pancreatic, Lymphatic, Angiectasis | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Congestion | |
Infiltration Cellular, Plasma Cell | 4 |
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Congestion | |
Depletion Lymphoid | 3 |
Giant Cell | 2 2 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Depletion Lymphoid | 4 2 2 |
Fibrosis | 4 4 2 3|
Hematopoietic Cell Proliferation | 4 4 3 |
Hypertrophy | 3 |
Infarct | |
Necrosis, Focal | |
Thrombosis | X |
Capsule, Congestion, Focal | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 6| 6| 4| 7| 5| 4| 7| 2| 7| 6| 7| 5| 7| 7| 7| 4| 2| 2| 2| 3| 4| 6| 7| 7|
DAY ON TEST | 5| 3| 3| 6| 3| 2| 6| 3| 7| 3| 9| 1| 6| 1| 3| 3| 6| 7| 7| 7| 0| 6| 3| 3| 3|
| 9| 2| 2| 3| 6| 4| 2| 6| 6| 6| 5| 5| 6| 7| 6| 6| 2| 6| 6| 5| 4| 3| 9| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | M + + + + M + M + + + M + + + M + + + + + + M + +|
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + M + + + + + + + + + + M|
Lactation | 1 4 2 4 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Fibrosis, Focal | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Callus | |
Hyperostosis | 2 2 |
Proliferation | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Hemorrhage, Focal | |
Hyperplasia, Adenomatous | |
Infiltration Cellular, Focal, | |
Histiocyte | 3 4 |
Peribronchial, Inflammation, Chronic | 1 1 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 4 4 4 |
Hyperkeratosis | 4 |
Hyperplasia, Basal Cell | 3 |
Inflammation, Acute | 4 |
Inflammation, Chronic, Focal | 2 2 2 2 |
Inflammation, Chronic | 2 2 3 1 |
Metaplasia, Squamous | 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 4| 6| 6| 4| 7| 5| 4| 7| 2| 7| 6| 7| 5| 7| 7| 7| 4| 2| 2| 2| 3| 4| 6| 7| 7|
DAY ON TEST | 5| 3| 3| 6| 3| 2| 6| 3| 7| 3| 9| 1| 6| 1| 3| 3| 6| 7| 7| 7| 0| 6| 3| 3| 3|
| 9| 2| 2| 3| 6| 4| 2| 6| 6| 6| 5| 5| 6| 7| 6| 6| 2| 6| 6| 5| 4| 3| 9| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Mineralization | 4 |
Necrosis, Focal | |
Nephropathy | 1 1 1 4 1 1 4 4 2 3 4 3 4 2 1 1 3 2|
Papilla, Necrosis | 4 |
Renal Tubule, Degeneration, Granular | 3 |
Renal Tubule, Pigmentation, Bile | 2 4|
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Ureter | + |
Hyperplasia | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +|
Calculus Micro Observation Only | X X |
Ulcer | 4 |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 7| 2| 4| 7| 4| 7| 2| 3| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 2| 6| 2| 7|
DAY ON TEST | 9| 3| 7| 6| 3| 6| 3| 7| 9| 6| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 0| 7| 6| 7| 3|
| 8| 5| 6| 3| 5| 3| 5| 5| 1| 2| 5| 5| 5| 5| 9| 5| 3| 6| 6| 6| 1| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Edema | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Cyst | X |
Developmental Malformation | X X |
Eosinophilic Focus | |
Fatty Change | 1 2 |
Fibrosis, Focal | |
Hepatodiaphragmatic Nodule | X X |
Necrosis, Focal | 3|
Proliferation | |
Bile Duct, Hyperplasia | 2 2 3 3 4 4 3 |
Lymphatic, Angiectasis, Focal | 4 |
__________________________________________________________________________|
Mesentery | + |
Accessory Spleen | X |
Fat, Hemorrhage | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 2 4 2 3 3 2 4 2 |
Acinus, Hyperplasia, Focal | 2 |
Vein, Thrombosis | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Thrombosis | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +|
Erosion | 2 1 2 |
Hyperplasia, Lymphoid | 3 2 2 3 |
Mucosa, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 7| 2| 4| 7| 4| 7| 2| 3| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 2| 6| 2| 7|
DAY ON TEST | 9| 3| 7| 6| 3| 6| 3| 7| 9| 6| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 0| 7| 6| 7| 3|
| 8| 5| 6| 3| 5| 3| 5| 5| 1| 2| 5| 5| 5| 5| 9| 5| 3| 6| 6| 6| 1| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 2 2 2 1 4 2 1 2 4 3 4 2 4 4 2 2 2 1|
Inflammation, Chronic, Focal | |
Mineralization | 1 1 1 |
Artery, Inflammation, Chronic | |
Atrium, Dilatation | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Cytoplasmic Alteration | |
Hypertrophy | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Focal | 1 1 1 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + I + + + + + M + +|
Ectopic Thymus | |
Hyperplasia, Focal | 3 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + A + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2|
Pars Distalis, Cyst | X|
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 1 2 3 |
Cyst | X X |
Ectasia | 3 4 |
Hyperplasia | |
Inflammation, Chronic, Focal | 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 7| 2| 4| 7| 4| 7| 2| 3| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 2| 6| 2| 7|
DAY ON TEST | 9| 3| 7| 6| 3| 6| 3| 7| 9| 6| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 0| 7| 6| 7| 3|
| 8| 5| 6| 3| 5| 3| 5| 5| 1| 2| 5| 5| 5| 5| 9| 5| 3| 6| 6| 6| 1| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 2 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 3 3 3 2 3 |
Dilatation | |
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 3 4 3 4 3 4 4 4 3 4 4 |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | 3 3 |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 4 3 4|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Congestion | |
Mediastinal, Lymphatic, Angiectasis | 3 3 3 |
Pancreatic, Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Angiectasis | 4 4 3 |
Congestion | |
Infiltration Cellular, Plasma Cell | 4 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 3 4 |
Congestion | |
Depletion Lymphoid | |
Giant Cell | 2 2 1 1 |
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | |
Fibrosis | 2 4 2 2 2 |
Hematopoietic Cell Proliferation | |
Hypertrophy | |
Infarct | 2 |
Necrosis, Focal | 3 |
Thrombosis | |
Capsule, Congestion, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 7| 2| 4| 7| 4| 7| 2| 3| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 2| 6| 2| 7|
DAY ON TEST | 9| 3| 7| 6| 3| 6| 3| 7| 9| 6| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 0| 7| 6| 7| 3|
| 8| 5| 6| 3| 5| 3| 5| 5| 1| 2| 5| 5| 5| 5| 9| 5| 3| 6| 6| 6| 1| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Capsule, Fibrosis | 3 3 |
__________________________________________________________________________|
Thymus | + + + M + M + + + + + + + + + + + M + + + + + + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + M M + M + + + M + + + + + +|
Lactation | 3 4 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Fibrosis, Focal | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Callus | 4 |
Hyperostosis | 3 |
Proliferation | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage, Focal | |
Hyperplasia, Adenomatous | 2 |
Infiltration Cellular, Focal, | |
Histiocyte | 3 3|
Peribronchial, Inflammation, Chronic | 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 4 3 4 4 4 2 4 4 4 4 |
Hyperkeratosis | |
Hyperplasia, Basal Cell | 4 |
Inflammation, Acute | 2 2 3 |
Inflammation, Chronic, Focal | 2 2 2 2 |
Inflammation, Chronic | 2 2 2 4 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 7| 2| 4| 7| 4| 7| 2| 3| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 2| 6| 2| 7|
DAY ON TEST | 9| 3| 7| 6| 3| 6| 3| 7| 9| 6| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 0| 7| 6| 7| 3|
| 8| 5| 6| 3| 5| 3| 5| 5| 1| 2| 5| 5| 5| 5| 9| 5| 3| 6| 6| 6| 1| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +|
Abscess | |
Mineralization | |
Necrosis, Focal | 3 |
Nephropathy | 3 4 1 4 1 4 1 4 2 2 3 1 3 3 1 1 1 1|
Papilla, Necrosis | |
Renal Tubule, Degeneration, Granular | 2|
Renal Tubule, Pigmentation, Bile | |
Renal Tubule, Regeneration | 2 1 1 |
__________________________________________________________________________|
Ureter | |
Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + A + A + +|
Calculus Micro Observation Only | X X |
Ulcer | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 4| 2| 7| 5| 5| 7| 6| 4| 7| 7| 7| 7| 2| 6| 6| 7| 7| 6| 6| 7| | |
DAY ON TEST | 6| 7| 3| 9| 5| 3| 7| 6| 3| 3| 3| 3| 7| 7| 1| 3| 3| 3| 7| 3| | |
| 2| 5| 5| 4| 0| 5| 2| 2| 5| 5| 6| 6| 5| 7| 2| 6| 6| 5| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + A + + + + + | 66 |
Parasite Metazoan | 4 | 8 3.2|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + | 68 |
Parasite Metazoan | 4 2 X | 10 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + A + + + + + | 66 |
Edema | | 2 3.5|
Parasite Metazoan | | 3 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + | 66 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + A + + + + + | 65 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + A + + + + + | 66 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis, Focal | | 2 3.5|
Basophilic Focus | X X X X X X X X X | 39 |
Clear Cell Focus | X X X X | 10 |
Cyst | X | 2 |
Developmental Malformation | | 3 |
Eosinophilic Focus | X X | 2 |
Fatty Change | 2 3 2 3 | 9 2.3|
Fibrosis, Focal | | 1 3.0|
Hepatodiaphragmatic Nodule | X | 3 |
Necrosis, Focal | 3 | 3 2.7|
Proliferation | | 1 3.0|
Bile Duct, Hyperplasia | 2 4 4 3 1 3 3 3 3 3 3 3 | 24 3.0|
Lymphatic, Angiectasis, Focal | 3 | 2 3.5|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Accessory Spleen | | 1 |
Fat, Hemorrhage | | 1 4.0|
Fat, Necrosis | 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 |
Acinus, Atrophy | 2 3 2 4 2 | 21 2.7|
Acinus, Hyperplasia, Focal | 2 | 2 2.0|
Vein, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 69 |
Atrophy | | 1 2.0|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + | 69 |
Hyperkeratosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 4| 2| 7| 5| 5| 7| 6| 4| 7| 7| 7| 7| 2| 6| 6| 7| 7| 6| 6| 7| | |
DAY ON TEST | 6| 7| 3| 9| 5| 3| 7| 6| 3| 3| 3| 3| 7| 7| 1| 3| 3| 3| 7| 3| | |
| 2| 5| 5| 4| 0| 5| 2| 2| 5| 5| 6| 6| 5| 7| 2| 6| 6| 5| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 3 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + | 68 |
Erosion | 4 3 1 | 8 2.3|
Hyperplasia, Lymphoid | | 4 2.5|
Mucosa, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy | 1 2 4 4 1 4 1 1 2 3 2 2 4 3 2 1 2 | 56 2.4|
Inflammation, Chronic, Focal | | 2 1.5|
Mineralization | | 4 1.3|
Artery, Inflammation, Chronic | 2 | 1 2.0|
Atrium, Dilatation | | 1 4.0|
Atrium, Thrombosis | X X X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Cytoplasmic Alteration, Focal | 2 2 | 2 2.0|
Cytoplasmic Alteration | | 1 2.0|
Hypertrophy | | 1 3.0|
Vacuolization Cytoplasmic | 4 3 | 3 3.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + + + + | 69 |
Hemorrhage | | 1 4.0|
Hyperplasia, Focal | 2 3 3 2 2 3 1 1 1 3 | 16 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 67 |
Ectopic Thymus | X | 1 |
Hyperplasia, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 68 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | 3 2 2 | 10 2.3|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
C-Cell, Hyperplasia | 3 | 5 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 4| 2| 7| 5| 5| 7| 6| 4| 7| 7| 7| 7| 2| 6| 6| 7| 7| 6| 6| 7| | |
DAY ON TEST | 6| 7| 3| 9| 5| 3| 7| 6| 3| 3| 3| 3| 7| 7| 1| 3| 3| 3| 7| 3| | |
| 2| 5| 5| 4| 0| 5| 2| 2| 5| 5| 6| 6| 5| 7| 2| 6| 6| 5| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Cellular | | 2 2.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Abscess | 3 3 3 | 7 2.4|
Cyst | X | 4 |
Ectasia | 4 3 4 | 5 3.6|
Hyperplasia | 4 | 1 4.0|
Inflammation, Chronic, Focal | 2 2 | 8 2.1|
Inflammation, Chronic | 2 4 2 2 2 | 17 2.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + M + + | 69 |
Atrophy | 4 3 2 | 18 2.7|
Dilatation | 4 2 | 2 3.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + A + + + + + + + + + + M + + | 68 |
Atrophy | 4 4 3 3 2 3 3 4 4 2 4 | 36 3.5|
Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Bilateral, Interstitial Cell, | | |
Hyperplasia | | 4 3.0|
Interstitial Cell, Hyperplasia | | 1 3.0|
Seminiferous Tubule, Atrophy | 2 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + M + + + + + + + + + + + + + | 69 |
Hyperplasia | 3 4 4 4 2 4 | 22 3.2|
Myelofibrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 12 |
Mediastinal, Congestion | | 1 3.0|
Mediastinal, Lymphatic, Angiectasis | | 4 3.0|
Pancreatic, Lymphatic, Angiectasis | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 68 |
Angiectasis | | 4 3.5|
Congestion | 3 | 1 3.0|
Infiltration Cellular, Plasma Cell | | 2 4.0|
Lymphatic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 69 |
Angiectasis | 4 | 5 3.8|
Congestion | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 4| 2| 7| 5| 5| 7| 6| 4| 7| 7| 7| 7| 2| 6| 6| 7| 7| 6| 6| 7| | |
DAY ON TEST | 6| 7| 3| 9| 5| 3| 7| 6| 3| 3| 3| 3| 7| 7| 1| 3| 3| 3| 7| 3| | |
| 2| 5| 5| 4| 0| 5| 2| 2| 5| 5| 6| 6| 5| 7| 2| 6| 6| 5| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | | 1 3.0|
Giant Cell | 1 2 | 8 1.6|
Lymphatic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | | 1 4.0|
Depletion Lymphoid | | 3 2.7|
Fibrosis | 2 3 3 4 3 | 14 2.9|
Hematopoietic Cell Proliferation | | 3 3.7|
Hypertrophy | | 1 3.0|
Infarct | 4 | 2 3.0|
Necrosis, Focal | | 1 3.0|
Thrombosis | | 1 |
Capsule, Congestion, Focal | | 1 3.0|
Capsule, Fibrosis | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + M + + + + + + + + + | 59 |
Depletion Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M M + + + M + + M + + + + + M + + | 57 |
Lactation | 2 1 3 2 | 14 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst Epithelial Inclusion | | 1 |
Fibrosis, Focal | 4 4 | 2 4.0|
Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + M + + + + + + + + + + + + + | 69 |
Callus | | 1 4.0|
Hyperostosis | 2 2 | 5 2.2|
Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Compression | | 2 4.0|
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Hemorrhage, Focal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 4| 2| 7| 5| 5| 7| 6| 4| 7| 7| 7| 7| 2| 6| 6| 7| 7| 6| 6| 7| | |
DAY ON TEST | 6| 7| 3| 9| 5| 3| 7| 6| 3| 3| 3| 3| 7| 7| 1| 3| 3| 3| 7| 3| | |
| 2| 5| 5| 4| 0| 5| 2| 2| 5| 5| 6| 6| 5| 7| 2| 6| 6| 5| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | 2 | 3 2.7|
Hemorrhage, Focal | 2 | 1 2.0|
Hyperplasia, Adenomatous | | 1 2.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 4 | 5 3.4|
Peribronchial, Inflammation, Chronic | 2 3 2 | 11 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Fungus | 4 3 4 | 18 3.7|
Hyperkeratosis | | 1 4.0|
Hyperplasia, Basal Cell | | 2 3.5|
Inflammation, Acute | | 4 2.8|
Inflammation, Chronic, Focal | 2 2 | 10 2.0|
Inflammation, Chronic | 3 3 | 10 2.4|
Metaplasia, Squamous | | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
__________________________________________________________________________|____________|
Eye | | 1 |
Retina, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 69 |
Abscess | | 1 4.0|
Mineralization | | 1 4.0|
Necrosis, Focal | | 1 3.0|
Nephropathy | 1 1 4 2 2 2 2 2 3 2 2 2 1 1 2 4 2 1 2 4 | 56 2.2|
Papilla, Necrosis | | 1 4.0|
Renal Tubule, Degeneration, Granular | | 2 2.5|
Renal Tubule, Pigmentation, Bile | 3 | 3 3.0|
Renal Tubule, Regeneration | | 5 1.2|
__________________________________________________________________________|____________|
Ureter | | 1 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + A + + M + + | 63 |
Calculus Micro Observation Only | X | 5 |
Ulcer | | 1 4.0|
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 7| 7| 3| 4| 4| 7| 7| 7| 7| 4| 2| 7| 7| 4| 7| 7| 7| 7| 2| 7| 6| 4| 7| 6|
DAY ON TEST | 7| 3| 3| 1| 6| 6| 3| 1| 3| 3| 6| 7| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 2| 3| 7|
| 5| 4| 4| 5| 3| 2| 4| 7| 5| 4| 3| 5| 4| 4| 3| 4| 5| 4| 5| 6| 4| 9| 9| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 4 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X 2 3 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + A + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 3 3 2 2 |
Atrophy | |
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Cyst | X |
Developmental Malformation | X |
Eosinophilic Focus | |
Fatty Change | 1 1 2 2|
Granuloma | |
Hepatodiaphragmatic Nodule | X |
Infarct | |
Necrosis, Focal | 2 |
Thrombosis | |
Bile Duct, Dilatation | 4 |
Bile Duct, Hyperplasia | 3 2 1 2 3 3 1 4 |
Lymphatic, Angiectasis, Focal | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4|
Acinus, Atrophy | 2 1 1 2 2 2 3 3 1 1 |
Acinus, Hyperplasia, Focal | 3 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Pharynx | + |
Palate, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 7| 7| 3| 4| 4| 7| 7| 7| 7| 4| 2| 7| 7| 4| 7| 7| 7| 7| 2| 7| 6| 4| 7| 6|
DAY ON TEST | 7| 3| 3| 1| 6| 6| 3| 1| 3| 3| 6| 7| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 2| 3| 7|
| 5| 4| 4| 5| 3| 2| 4| 7| 5| 4| 3| 5| 4| 4| 3| 4| 5| 4| 5| 6| 4| 9| 9| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4|
Hyperplasia, Lymphoid | 2 3 |
Submucosa, Fibrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 1 1 4 2 2 2 1 3 2 3 3 2 1 4 3 2 1 1|
Inflammation, Chronic, Focal | 1 |
Artery, Inflammation, Chronic | 2 |
Atrium, Dilatation | 4 |
Ventricle, Dilatation | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
Hyperplasia, Focal | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4|
Hyperplasia, Focal | 3 3 2 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + I + + + + + + + + + + + + + + M + + + M + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 2 1 2 2 2 4 3 |
Pars Distalis, Inflammation, Chronic,| |
Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 3 1 2 |
Follicle, Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Abscess | 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 7| 7| 3| 4| 4| 7| 7| 7| 7| 4| 2| 7| 7| 4| 7| 7| 7| 7| 2| 7| 6| 4| 7| 6|
DAY ON TEST | 7| 3| 3| 1| 6| 6| 3| 1| 3| 3| 6| 7| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 2| 3| 7|
| 5| 4| 4| 5| 3| 2| 4| 7| 5| 4| 3| 5| 4| 4| 3| 4| 5| 4| 5| 6| 4| 9| 9| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X |
Ectasia | |
Inflammation, Acute | 2 3 |
Inflammation, Chronic, Focal | 2 1 2 |
Inflammation, Chronic | 2 2 2 3 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 2 2 |
Dilatation | 2 |
Inflammation, Focal | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 4 4 4 4 3 3 3 4 4 4 4 4 2|
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 2 1 1 4 4|
__________________________________________________________________________|
Lymph Node | + + + + + +|
Inguinal, Lymphatic, Angiectasis | |
Mediastinal, Congestion | |
Mediastinal, Granuloma | 4 |
Mediastinal, Pigmentation | |
Mediastinal, Lymphatic, Angiectasis | 3 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Pancreatic, Lymphatic, Angiectasis | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Congestion | |
Infiltration Cellular, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | |
Giant Cell | 2 2 1 |
Lymphatic, Angiectasis | 4 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | |
Fibrosis | 3 3 4 2 3 3 1 3|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 7| 7| 3| 4| 4| 7| 7| 7| 7| 4| 2| 7| 7| 4| 7| 7| 7| 7| 2| 7| 6| 4| 7| 6|
DAY ON TEST | 7| 3| 3| 1| 6| 6| 3| 1| 3| 3| 6| 7| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 2| 3| 7|
| 5| 4| 4| 5| 3| 2| 4| 7| 5| 4| 3| 5| 4| 4| 3| 4| 5| 4| 5| 6| 4| 9| 9| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 |
Infarct | 3 2 3|
Thrombosis | |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M + + + + + + + + + + + + + + + + M M + + M|
Lactation | 1 1 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Focal, Granulomatous | |
Hair Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage, Focal | |
Peribronchial, Inflammation, Chronic | 2 2 2 |
Pleura, Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + M + + +|
Fungus | 3 4 3 4 3 4 4 4|
Hyperkeratosis | 4 |
Inflammation, Acute | 4 2 4 2 2 4 |
Inflammation, Chronic, Focal | 2 2 2 |
Inflammation, Chronic | 2 |
Metaplasia, Squamous | 2 |
Respiratory Epithelium, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 7| 7| 3| 4| 4| 7| 7| 7| 7| 4| 2| 7| 7| 4| 7| 7| 7| 7| 2| 7| 6| 4| 7| 6|
DAY ON TEST | 7| 3| 3| 1| 6| 6| 3| 1| 3| 3| 6| 7| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 2| 3| 7|
| 5| 4| 4| 5| 3| 2| 4| 7| 5| 4| 3| 5| 4| 4| 3| 4| 5| 4| 5| 6| 4| 9| 9| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Glomerulosclerosis | |
Nephropathy | 1 3 2 2 2 2 1 2 3 2 4 3 2 2 2 1 3 3 3 3 2|
Medulla, Casts | X |
Renal Tubule, Degeneration, Granular | 2 |
Renal Tubule, Pigmentation, Bile | 3|
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 2| 6| 6| 2| 7| 4| 2| 7| 7| 7| 4| 2| 7| 7| 4| 7| 4| 7| 4| 0| 7| 2| 7| 2|
DAY ON TEST | 5| 7| 7| 8| 7| 3| 6| 7| 3| 3| 3| 6| 7| 2| 3| 6| 3| 6| 3| 6| 4| 3| 7| 3| 7|
| 0| 6| 5| 7| 6| 4| 3| 6| 4| 4| 4| 3| 5| 4| 4| 3| 4| 3| 4| 2| 3| 4| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 4 |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X 2 4 4 4 X|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Parasite Metazoan | X 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Atrophy | |
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Cyst | |
Developmental Malformation | |
Eosinophilic Focus | |
Fatty Change | |
Granuloma | 3 |
Hepatodiaphragmatic Nodule | X |
Infarct | 4 |
Necrosis, Focal | |
Thrombosis | X |
Bile Duct, Dilatation | |
Bile Duct, Hyperplasia | 3 3 1 3 3 1 3 4 1 2 2 3 2 2 |
Lymphatic, Angiectasis, Focal | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Acinus, Atrophy | 4 1 2 2 2 2 4 3 1 |
Acinus, Hyperplasia, Focal | |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Pharynx | |
Palate, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 2| 6| 6| 2| 7| 4| 2| 7| 7| 7| 4| 2| 7| 7| 4| 7| 4| 7| 4| 0| 7| 2| 7| 2|
DAY ON TEST | 5| 7| 7| 8| 7| 3| 6| 7| 3| 3| 3| 6| 7| 2| 3| 6| 3| 6| 3| 6| 4| 3| 7| 3| 7|
| 0| 6| 5| 7| 6| 4| 3| 6| 4| 4| 4| 3| 5| 4| 4| 3| 4| 3| 4| 2| 3| 4| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 3 1 |
Hyperplasia, Lymphoid | |
Submucosa, Fibrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 3 2 4 2 3 2 2 2 3 1 1 2 2 3 |
Inflammation, Chronic, Focal | 1 1 1 1|
Artery, Inflammation, Chronic | |
Atrium, Dilatation | |
Ventricle, Dilatation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 3 |
Hyperplasia, Focal | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Focal | 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia, Focal | 1 1 2 2 |
Pars Distalis, Inflammation, Chronic,| |
Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 2| 6| 6| 2| 7| 4| 2| 7| 7| 7| 4| 2| 7| 7| 4| 7| 4| 7| 4| 0| 7| 2| 7| 2|
DAY ON TEST | 5| 7| 7| 8| 7| 3| 6| 7| 3| 3| 3| 6| 7| 2| 3| 6| 3| 6| 3| 6| 4| 3| 7| 3| 7|
| 0| 6| 5| 7| 6| 4| 3| 6| 4| 4| 4| 3| 5| 4| 4| 3| 4| 3| 4| 2| 3| 4| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X X X X |
Ectasia | 3 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic, Focal | 2 3 3 3|
Inflammation, Chronic | 2 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 2 3 2 |
Dilatation | |
Inflammation, Focal | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 3 3 4 4 3 3 3 4 4 |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Bilateral, Interstitial Cell, | |
Hyperplasia | |
Interstitial Cell, Hyperplasia | 3 |
Seminiferous Tubule, Atrophy | 4 4 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 3 4 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Inguinal, Lymphatic, Angiectasis | |
Mediastinal, Congestion | 3 |
Mediastinal, Granuloma | |
Mediastinal, Pigmentation | 3 |
Mediastinal, Lymphatic, Angiectasis | 2 |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Lymphatic, Angiectasis | 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 4 |
Depletion Lymphoid | |
Giant Cell | 2 2 2 1 2 1|
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Depletion Lymphoid | |
Fibrosis | 3 4 3 4 |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 2| 6| 6| 2| 7| 4| 2| 7| 7| 7| 4| 2| 7| 7| 4| 7| 4| 7| 4| 0| 7| 2| 7| 2|
DAY ON TEST | 5| 7| 7| 8| 7| 3| 6| 7| 3| 3| 3| 6| 7| 2| 3| 6| 3| 6| 3| 6| 4| 3| 7| 3| 7|
| 0| 6| 5| 7| 6| 4| 3| 6| 4| 4| 4| 3| 5| 4| 4| 3| 4| 3| 4| 2| 3| 4| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
Infarct | 4 4 |
Thrombosis | X |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + + M + M + + + + + + + + + + + + + M + + +|
Lactation | 2 1 1 1 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Inflammation, Focal, Granulomatous | |
Hair Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | 4 |
Peribronchial, Inflammation, Chronic | 2 2 2 1 2 2|
Pleura, Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 4 3 4 4 |
Hyperkeratosis | |
Inflammation, Acute | 3 |
Inflammation, Chronic, Focal | 2 2 2 1 2 2|
Inflammation, Chronic | 2 1 2 2 |
Metaplasia, Squamous | |
Respiratory Epithelium, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 2| 6| 6| 2| 7| 4| 2| 7| 7| 7| 4| 2| 7| 7| 4| 7| 4| 7| 4| 0| 7| 2| 7| 2|
DAY ON TEST | 5| 7| 7| 8| 7| 3| 6| 7| 3| 3| 3| 6| 7| 2| 3| 6| 3| 6| 3| 6| 4| 3| 7| 3| 7|
| 0| 6| 5| 7| 6| 4| 3| 6| 4| 4| 4| 3| 5| 4| 4| 3| 4| 3| 4| 2| 3| 4| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Glomerulosclerosis | 3 |
Nephropathy | 1 2 2 2 1 2 2 3 2 2 1 1 1 1 3 2 2 1|
Medulla, Casts | |
Renal Tubule, Degeneration, Granular | |
Renal Tubule, Pigmentation, Bile | 1 |
Renal Tubule, Regeneration | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 2| 5| 6| 7| 7| 5| 6| 7| 4| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 3| 5| 3| 3| 4| 2| 3| 6| 3| 0| 9| 3| 3| 0| 3| 3| 3| 3| 3| | |
| 6| 3| 0| 5| 5| 7| 3| 5| 2| 5| 0| 6| 5| 5| 9| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + A + + + + + | 66 |
Parasite Metazoan | 3 2 | 8 2.9|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + + + A + + + + + | 67 |
Parasite Metazoan | 4 4 2 2 3 | 15 3.2|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + A + + A + + + + + | 64 |
Hyperplasia, Lymphoid | | 1 4.0|
Parasite Metazoan | X 4 | 4 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + A + + + + + | 66 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + A + + + + + A + + A + + + + + | 63 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis, Focal | | 7 2.3|
Atrophy | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X | 46 |
Clear Cell Focus | X X X | 8 |
Cyst | | 1 |
Developmental Malformation | | 1 |
Eosinophilic Focus | X | 1 |
Fatty Change | 3 | 5 1.8|
Granuloma | | 1 3.0|
Hepatodiaphragmatic Nodule | X | 3 |
Infarct | | 1 4.0|
Necrosis, Focal | | 1 2.0|
Thrombosis | | 1 |
Bile Duct, Dilatation | | 1 4.0|
Bile Duct, Hyperplasia | 2 2 1 4 2 3 4 4 4 | 31 2.5|
Lymphatic, Angiectasis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Fat, Necrosis | 3 4 | 5 3.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 1 4.0|
Acinus, Atrophy | 4 2 4 1 2 4 4 4 3 | 28 2.4|
Acinus, Hyperplasia, Focal | 3 | 2 3.0|
Artery, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 2| 5| 6| 7| 7| 5| 6| 7| 4| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 3| 5| 3| 3| 4| 2| 3| 6| 3| 0| 9| 3| 3| 0| 3| 3| 3| 3| 3| | |
| 6| 3| 0| 5| 5| 7| 3| 5| 2| 5| 0| 6| 5| 5| 9| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy | 2 | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | 1 | 1 1.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Erosion | 2 | 5 2.6|
Hyperplasia, Lymphoid | | 2 2.5|
Submucosa, Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy | 1 2 1 3 2 3 2 3 2 2 1 2 1 | 50 2.1|
Inflammation, Chronic, Focal | 1 | 6 1.0|
Artery, Inflammation, Chronic | | 1 2.0|
Atrium, Dilatation | | 1 4.0|
Ventricle, Dilatation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 69 |
Cytoplasmic Alteration, Focal | 2 2 | 4 2.3|
Hyperplasia, Focal | 4 | 1 4.0|
Vacuolization Cytoplasmic | 3 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + A + + + + + + + + + + + + + + + + + | 68 |
Hemorrhage | | 1 4.0|
Hyperplasia, Focal | 3 2 | 12 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + | 66 |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Pars Distalis, Angiectasis | 2 2 | 2 2.0|
Pars Distalis, Cyst | | 3 |
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | 2 4 2 | 14 2.1|
Pars Distalis, Inflammation, Chronic,| | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 3 1 | 6 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 2| 5| 6| 7| 7| 5| 6| 7| 4| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 3| 5| 3| 3| 4| 2| 3| 6| 3| 0| 9| 3| 3| 0| 3| 3| 3| 3| 3| | |
| 6| 3| 0| 5| 5| 7| 3| 5| 2| 5| 0| 6| 5| 5| 9| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + M + + + + + + + + + + + + + + + + + | 69 |
Depletion Cellular | 2 | 2 2.5|
__________________________________________________________________________|____________|
Preputial Gland | + + M + + M + + + + + + + + + + + + + + | 67 |
Abscess | | 4 2.3|
Cyst | | 5 |
Ectasia | 2 | 2 2.5|
Inflammation, Acute | 3 | 5 2.4|
Inflammation, Chronic, Focal | 2 | 8 2.3|
Inflammation, Chronic | 3 3 | 11 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 70 |
Atrophy | | 11 2.3|
Dilatation | | 1 2.0|
Inflammation, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 |
Atrophy | 3 3 3 4 4 3 3 3 3 3 | 36 3.4|
Dilatation | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Testes | + + M + + + + + + + + + + + + + + + + + | 69 |
Hemorrhage, Focal | 4 | 1 4.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia | | 1 2.0|
Interstitial Cell, Hyperplasia | 3 3 3 | 5 2.8|
Seminiferous Tubule, Atrophy | 4 | 5 3.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 2 4 2 2 2 4 | 19 3.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 19 |
Inguinal, Lymphatic, Angiectasis | 3 | 1 3.0|
Mediastinal, Congestion | | 1 3.0|
Mediastinal, Granuloma | | 1 4.0|
Mediastinal, Pigmentation | | 1 3.0|
Mediastinal, Lymphatic, Angiectasis | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 2| 5| 6| 7| 7| 5| 6| 7| 4| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 3| 5| 3| 3| 4| 2| 3| 6| 3| 0| 9| 3| 3| 0| 3| 3| 3| 3| 3| | |
| 6| 3| 0| 5| 5| 7| 3| 5| 2| 5| 0| 6| 5| 5| 9| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Lymphatic, Angiectasis | 3 | 4 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 69 |
Angiectasis | | 2 3.0|
Congestion | 4 | 1 4.0|
Infiltration Cellular, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | 4 3 4 | 5 3.6|
Depletion Lymphoid | 4 | 1 4.0|
Giant Cell | 2 | 10 1.7|
Lymphatic, Angiectasis | | 2 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | 2 | 2 2.5|
Depletion Lymphoid | 4 3 | 2 3.5|
Fibrosis | 2 3 3 4 4 | 17 3.1|
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Infarct | 4 2 | 7 3.1|
Thrombosis | | 1 |
Capsule, Fibrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + M + + + + + + | 67 |
Hemorrhage, Focal | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + + + M + + M + M M + + + + + M + | 53 |
Lactation | 1 2 2 1 | 14 1.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Acanthosis | | 1 3.0|
Inflammation, Focal, Granulomatous | 3 | 1 3.0|
Hair Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperostosis | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemorrhage | | 2 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 2| 5| 6| 7| 7| 5| 6| 7| 4| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 3| 5| 3| 3| 4| 2| 3| 6| 3| 0| 9| 3| 3| 0| 3| 3| 3| 3| 3| | |
| 6| 3| 0| 5| 5| 7| 3| 5| 2| 5| 0| 6| 5| 5| 9| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | | 1 3.0|
Hemorrhage, Focal | | 1 4.0|
Peribronchial, Inflammation, Chronic | 2 | 10 1.9|
Pleura, Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 69 |
Fungus | 4 4 4 4 2 | 18 3.7|
Hyperkeratosis | | 1 4.0|
Inflammation, Acute | 2 1 | 9 2.7|
Inflammation, Chronic, Focal | 2 | 10 1.9|
Inflammation, Chronic | 2 2 | 7 1.9|
Metaplasia, Squamous | | 1 2.0|
Respiratory Epithelium, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | | 1 2.0|
Retina, Degeneration | 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | X | 2 |
Glomerulosclerosis | | 1 3.0|
Nephropathy | 2 3 4 1 2 2 1 1 1 2 4 1 1 2 1 1 2 4 | 57 2.0|
Medulla, Casts | | 1 |
Renal Tubule, Degeneration, Granular | 3 | 2 2.5|
Renal Tubule, Pigmentation, Bile | | 2 2.0|
Renal Tubule, Regeneration | | 4 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + M + + A + + + + + A + + A + + + + + | 64 |
Calculus Micro Observation Only | | 1 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 4| 7| 7| 7| 6| 3| 4| 3| 6| 7| 7| 4| 2| 7| 7| 4| 7| 7| 2| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 6| 3| 3| 3| 5| 2| 6| 8| 2| 3| 3| 6| 7| 3| 3| 6| 0| 3| 7| 2|
| 5| 1| 1| 1| 1| 2| 1| 1| 1| 3| 5| 3| 3| 4| 1| 1| 3| 5| 4| 1| 3| 0| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + M + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | X 4 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | 2 4 X 3 X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + A + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + A + + + + + + + + + + A|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Atrophy | 3|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Developmental Malformation | X |
Fatty Change | 1 2 |
Fibrosis, Focal | |
Granuloma | 4 2 |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | |
Necrosis, Focal | |
Thrombosis | |
Bile Duct, Hyperplasia | 2 3 3 3 1 3 3 2 2|
Lymphatic, Angiectasis, Focal | 3 4 |
__________________________________________________________________________|
Mesentery | + + + + + |
Accessory Spleen | |
Cyst | X |
Fibrosis | |
Fat, Necrosis | 3 3 3 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Focal | |
Acinus, Atrophy | 3 2 3 2 2 1 |
Acinus, Hyperplasia, Focal | |
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4|
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 4| 7| 7| 7| 6| 3| 4| 3| 6| 7| 7| 4| 2| 7| 7| 4| 7| 7| 2| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 6| 3| 3| 3| 5| 2| 6| 8| 2| 3| 3| 6| 7| 3| 3| 6| 0| 3| 7| 2|
| 5| 1| 1| 1| 1| 2| 1| 1| 1| 3| 5| 3| 3| 4| 1| 1| 3| 5| 4| 1| 3| 0| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 1 2 1 2 1 2 2 1 2 3 2 2 2|
Inflammation, Chronic, Focal | |
Mineralization | |
Artery, Inflammation, Chronic | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 3|
Hyperplasia | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 1 3 2 2 2 1 3 2 |
Pars Intermedia, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Ectasia | |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 3 2 3 |
Inflammation, Chronic | 2 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 3 3 3 4|
Congestion | |
Dilatation | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 4| 7| 7| 7| 6| 3| 4| 3| 6| 7| 7| 4| 2| 7| 7| 4| 7| 7| 2| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 6| 3| 3| 3| 5| 2| 6| 8| 2| 3| 3| 6| 7| 3| 3| 6| 0| 3| 7| 2|
| 5| 1| 1| 1| 1| 2| 1| 1| 1| 3| 5| 3| 3| 4| 1| 1| 3| 5| 4| 1| 3| 0| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 3 3 4 4 2 4 4|
Cyst | |
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 2 3 |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 4 |
Hyperplasia | 4 3 4 1 2 3 4 2 2|
Myelofibrosis | 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Lumbar, Lymphatic, Angiectasis | 3|
Mediastinal, Congestion | 2 |
Mediastinal, Lymphatic, Angiectasis | |
Pancreatic, Lymphatic, Angiectasis | 4 3 |
Renal, Pigmentation | 4 |
Renal, Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | 3|
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | 4|
Giant Cell | 2 1 2 |
Hyperplasia, Lymphoid | |
Lymphatic, Angiectasis | 4 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 4 2 4|
Fibrosis | 2 3 4 |
Hematopoietic Cell Proliferation | 2 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | |
Depletion Lymphoid | 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + M + + + + + + + M M + +|
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 4| 7| 7| 7| 6| 3| 4| 3| 6| 7| 7| 4| 2| 7| 7| 4| 7| 7| 2| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 6| 3| 3| 3| 5| 2| 6| 8| 2| 3| 3| 6| 7| 3| 3| 6| 0| 3| 7| 2|
| 5| 1| 1| 1| 1| 2| 1| 1| 1| 3| 5| 3| 3| 4| 1| 1| 3| 5| 4| 1| 3| 0| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Lactation | 2 1 1 |
__________________________________________________________________________|
Skin | M + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Fibrosis, Focal | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | +|
Degeneration | 4|
__________________________________________________________________________|
Spinal Cord | +|
Degeneration | 4|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Peribronchial, Inflammation, Chronic | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + M + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 3 4|
Hyperkeratosis | |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 2 2 1 |
Inflammation, Chronic | 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | 3 |
Nephropathy | 1 2 2 1 1 2 2 1 2 1 2 1 3 4 1 1 1 1 1 1 1|
Renal Tubule, Degeneration, Granular | |
Renal Tubule, Pigmentation, Bile | 3 4 4 |
Renal Tubule, Regeneration | 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 4| 7| 7| 7| 6| 3| 4| 3| 6| 7| 7| 4| 2| 7| 7| 4| 7| 7| 2| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 6| 3| 3| 3| 5| 2| 6| 8| 2| 3| 3| 6| 7| 3| 3| 6| 0| 3| 7| 2|
| 5| 1| 1| 1| 1| 2| 1| 1| 1| 3| 5| 3| 3| 4| 1| 1| 3| 5| 4| 1| 3| 0| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Calculus Micro Observation Only | |
Ectasia | 2|
Hemorrhage | 3|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 2| 7| 4| 7| 4| 7| 7| 7| 4| 5| 7| 7| 4| 6| 7| 7| 7| 2| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 7| 7| 0| 0| 3| 6| 3| 3| 3| 6| 4| 3| 2| 6| 7| 3| 3| 3| 7| 3| 8| 3| 6| 3| 7|
| 5| 5| 1| 6| 1| 3| 1| 1| 1| 3| 2| 1| 2| 2| 4| 4| 4| 4| 6| 4| 1| 1| 2| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | X X 2 4 4 4 3 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + A A + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + + + + + A + + + + + + + + + A + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 3 |
Atrophy | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X|
Developmental Malformation | X |
Fatty Change | 2 1 |
Fibrosis, Focal | |
Granuloma | |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X |
Necrosis, Focal | 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 2 4 3 4 3 2 3|
Lymphatic, Angiectasis, Focal | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Accessory Spleen | X |
Cyst | |
Fibrosis | |
Fat, Necrosis | 2 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Focal | 3 |
Acinus, Atrophy | 2 1 4 1 2 2 |
Acinus, Hyperplasia, Focal | |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Erosion | 3 3 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 2| 7| 4| 7| 4| 7| 7| 7| 4| 5| 7| 7| 4| 6| 7| 7| 7| 2| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 7| 7| 0| 0| 3| 6| 3| 3| 3| 6| 4| 3| 2| 6| 7| 3| 3| 3| 7| 3| 8| 3| 6| 3| 7|
| 5| 5| 1| 6| 1| 3| 1| 1| 1| 3| 2| 1| 2| 2| 4| 4| 4| 4| 6| 4| 1| 1| 2| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 2 3 2 2 2 2 3 3 1 1 1 3 3 3 1 2|
Inflammation, Chronic, Focal | 1 2 |
Mineralization | |
Artery, Inflammation, Chronic | |
Atrium, Thrombosis | X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Hyperplasia | 2 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 1 2 2 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + A + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 |
Pars Intermedia, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 2|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 |
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Ectasia | 3 |
Inflammation, Acute | 3 |
Inflammation, Chronic, Focal | 2 2 2 |
Inflammation, Chronic | 2 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + M + + + + + + + + + + + +|
Atrophy | 3 3 3 3 |
Congestion | |
Dilatation | 3 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 2| 7| 4| 7| 4| 7| 7| 7| 4| 5| 7| 7| 4| 6| 7| 7| 7| 2| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 7| 7| 0| 0| 3| 6| 3| 3| 3| 6| 4| 3| 2| 6| 7| 3| 3| 3| 7| 3| 8| 3| 6| 3| 7|
| 5| 5| 1| 6| 1| 3| 1| 1| 1| 3| 2| 1| 2| 2| 4| 4| 4| 4| 6| 4| 1| 1| 2| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + M + + + + + + + + + + + +|
Atrophy | 3 4 4 3 3 2 3 4 4 4 3 3 2 4|
Cyst | X |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Hyperplasia | 3 2 2 3 4 4 3 4 4 4 2 4|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Lumbar, Lymphatic, Angiectasis | |
Mediastinal, Congestion | |
Mediastinal, Lymphatic, Angiectasis | 4 3 |
Pancreatic, Lymphatic, Angiectasis | 3 |
Renal, Pigmentation | |
Renal, Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + M +|
Angiectasis | 2 3 |
Depletion Lymphoid | |
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + A + + + + + + + + + + + + + +|
Angiectasis | 4 |
Depletion Lymphoid | |
Giant Cell | 1 2 2 |
Hyperplasia, Lymphoid | 3 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Depletion Lymphoid | 3 4 |
Fibrosis | 2 4 2 |
Hematopoietic Cell Proliferation | |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
Cyst | X |
Depletion Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + + M + + + + + + M + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 2| 7| 4| 7| 4| 7| 7| 7| 4| 5| 7| 7| 4| 6| 7| 7| 7| 2| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 7| 7| 0| 0| 3| 6| 3| 3| 3| 6| 4| 3| 2| 6| 7| 3| 3| 3| 7| 3| 8| 3| 6| 3| 7|
| 5| 5| 1| 6| 1| 3| 1| 1| 1| 3| 2| 1| 2| 2| 4| 4| 4| 4| 6| 4| 1| 1| 2| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Lactation | 1 1 1 1 1 1 2|
__________________________________________________________________________|
Skin | + M + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Fibrosis, Focal | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 2 |
__________________________________________________________________________|
Skeletal Muscle | + + + + |
Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
Degeneration | |
__________________________________________________________________________|
Spinal Cord | |
Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 2 2 2 |
Peribronchial, Inflammation, Chronic | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 3 4 3 4 3 4 |
Hyperkeratosis | 4 |
Inflammation, Acute | 1 |
Inflammation, Chronic, Focal | 1 2 2 |
Inflammation, Chronic | 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Nephropathy | 2 2 3 2 2 2 2 2 2 1 2 2 3 2 2 2 2 2 1 1 1|
Renal Tubule, Degeneration, Granular | 3 3 |
Renal Tubule, Pigmentation, Bile | 2 |
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + A + M + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 2| 7| 4| 7| 4| 7| 7| 7| 4| 5| 7| 7| 4| 6| 7| 7| 7| 2| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 7| 7| 0| 0| 3| 6| 3| 3| 3| 6| 4| 3| 2| 6| 7| 3| 3| 3| 7| 3| 8| 3| 6| 3| 7|
| 5| 5| 1| 6| 1| 3| 1| 1| 1| 3| 2| 1| 2| 2| 4| 4| 4| 4| 6| 4| 1| 1| 2| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Calculus Micro Observation Only | X |
Ectasia | |
Hemorrhage | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 7| 4| 7| 6| 7| 7| 2| 2| 7| 7| 7| 7| 5| 2| | |
DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 6| 3| 7| 3| 3| 7| 7| 3| 3| 3| 3| 6| 7| | |
| 0| 2| 6| 1| 0| 0| 0| 2| 0| 7| 4| 4| 5| 6| 4| 1| 1| 1| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + | 65 |
Parasite Metazoan | 2 2 3 2 | 11 2.7|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 68 |
Parasite Metazoan | 4 4 | 15 3.5|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + | 64 |
Parasite Metazoan | X X | 3 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + | 66 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + | 64 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + | 62 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis, Focal | | 3 2.3|
Atrophy | | 2 3.0|
Basophilic Focus | X X X X X X X X X X X | 41 |
Clear Cell Focus | X X X X X X | 14 |
Developmental Malformation | X | 3 |
Fatty Change | | 4 1.5|
Fibrosis, Focal | 2 | 1 2.0|
Granuloma | 2 | 3 2.7|
Hepatodiaphragmatic Nodule | | 3 |
Mixed Cell Focus | | 1 |
Necrosis, Focal | | 1 2.0|
Thrombosis | X | 1 |
Bile Duct, Hyperplasia | 3 2 4 | 19 2.7|
Lymphatic, Angiectasis, Focal | 3 | 4 3.3|
__________________________________________________________________________|____________|
Mesentery | + + | 14 |
Accessory Spleen | | 1 |
Cyst | | 1 |
Fibrosis | 2 | 1 2.0|
Fat, Necrosis | 3 | 10 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + A + | 69 |
Pigmentation, Focal | | 1 3.0|
Acinus, Atrophy | 3 1 3 2 3 3 2 2 2 2 | 22 2.2|
Acinus, Hyperplasia, Focal | 2 | 1 2.0|
Artery, Inflammation, Chronic | 4 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst Epithelial Inclusion | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 7| 4| 7| 6| 7| 7| 2| 2| 7| 7| 7| 7| 5| 2| | |
DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 6| 3| 7| 3| 3| 7| 7| 3| 3| 3| 3| 6| 7| | |
| 0| 2| 6| 1| 0| 0| 0| 2| 0| 7| 4| 4| 5| 6| 4| 1| 1| 1| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + | 68 |
Erosion | | 3 3.3|
Hyperplasia, Lymphoid | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy | 1 2 2 3 1 2 3 1 1 3 3 1 | 49 1.9|
Inflammation, Chronic, Focal | 1 1 1 | 5 1.2|
Mineralization | 1 | 1 1.0|
Artery, Inflammation, Chronic | 2 | 1 2.0|
Atrium, Thrombosis | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + | 69 |
Cytoplasmic Alteration, Focal | | 1 3.0|
Hyperplasia | | 2 2.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + | 69 |
Hyperplasia, Focal | 1 1 1 1 | 17 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 68 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 68 |
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 | 17 2.0|
Pars Intermedia, Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
C-Cell, Hyperplasia | 1 1 2 | 8 2.0|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Cellular | 4 | 2 3.5|
Spermatocele | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 7| 4| 7| 6| 7| 7| 2| 2| 7| 7| 7| 7| 5| 2| | |
DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 6| 3| 7| 3| 3| 7| 7| 3| 3| 3| 3| 6| 7| | |
| 0| 2| 6| 1| 0| 0| 0| 2| 0| 7| 4| 4| 5| 6| 4| 1| 1| 1| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | | 2 |
Ectasia | | 1 3.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic, Focal | 2 1 | 8 2.1|
Inflammation, Chronic | 2 3 | 11 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 69 |
Atrophy | 3 | 12 2.8|
Congestion | 3 | 1 3.0|
Dilatation | | 1 3.0|
Inflammation, Acute | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 69 |
Atrophy | 4 4 3 4 3 4 4 3 2 3 3 3 | 38 3.4|
Cyst | | 1 |
Dilatation | 4 | 2 3.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Bilateral, Interstitial Cell, | | |
Hyperplasia | 3 | 5 2.4|
Interstitial Cell, Hyperplasia | 4 | 2 3.0|
Seminiferous Tubule, Atrophy | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Granuloma | | 1 4.0|
Hyperplasia | 4 4 | 23 3.1|
Myelofibrosis | | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 16 |
Lumbar, Lymphatic, Angiectasis | | 1 3.0|
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Lymphatic, Angiectasis | 3 | 3 3.3|
Pancreatic, Lymphatic, Angiectasis | 2 | 4 3.0|
Renal, Pigmentation | | 1 4.0|
Renal, Lymphatic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 68 |
Angiectasis | 2 3 | 4 2.5|
Depletion Lymphoid | | 1 3.0|
Lymphatic, Angiectasis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 68 |
Angiectasis | 4 | 2 4.0|
Depletion Lymphoid | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 7| 4| 7| 6| 7| 7| 2| 2| 7| 7| 7| 7| 5| 2| | |
DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 6| 3| 7| 3| 3| 7| 7| 3| 3| 3| 3| 6| 7| | |
| 0| 2| 6| 1| 0| 0| 0| 2| 0| 7| 4| 4| 5| 6| 4| 1| 1| 1| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Giant Cell | 1 1 1 2 | 10 1.5|
Hyperplasia, Lymphoid | | 1 3.0|
Lymphatic, Angiectasis | 4 | 3 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Congestion | | 1 4.0|
Depletion Lymphoid | 3 | 6 3.3|
Fibrosis | 3 4 2 | 9 2.9|
Hematopoietic Cell Proliferation | | 1 2.0|
Capsule, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + | 67 |
Cyst | X | 2 |
Depletion Lymphoid | | 2 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + M + I + M + M + M + M + + + + | 53 |
Lactation | 1 2 | 12 1.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 68 |
Abscess | | 1 3.0|
Fibrosis, Focal | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperostosis | | 3 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 6 |
Fibrosis | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Granuloma | | 3 2.0|
Peribronchial, Inflammation, Chronic | 2 2 2 | 9 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 7| 4| 7| 6| 7| 7| 2| 2| 7| 7| 7| 7| 5| 2| | |
DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 6| 3| 7| 3| 3| 7| 7| 3| 3| 3| 3| 6| 7| | |
| 0| 2| 6| 1| 0| 0| 0| 2| 0| 7| 4| 4| 5| 6| 4| 1| 1| 1| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fungus | 4 3 4 4 2 4 | 16 3.5|
Hyperkeratosis | | 1 4.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic, Focal | 2 2 2 2 | 10 1.8|
Inflammation, Chronic | 2 2 4 | 13 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 3 3.3|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Glomerulosclerosis | | 1 3.0|
Nephropathy | 2 1 2 1 2 2 2 4 2 4 2 2 2 4 2 1 1 | 59 1.8|
Renal Tubule, Degeneration, Granular | | 2 3.0|
Renal Tubule, Pigmentation, Bile | 3 | 5 3.2|
Renal Tubule, Regeneration | 1 1 | 6 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + | 63 |
Calculus Micro Observation Only | X X | 3 |
Ectasia | | 1 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 5| 3| 7| 2| 7| 1| 4| 7| 2| 4| 7| 4| 7| 7| 4| 4| 6| 7| 4| 3| 7| 4| 4| 7|
DAY ON TEST | 5| 1| 8| 3| 7| 2| 8| 6| 2| 7| 6| 3| 3| 3| 3| 6| 6| 8| 3| 6| 5| 3| 6| 6| 3|
| 3| 8| 6| 0| 5| 9| 7| 3| 9| 6| 2| 0| 9| 0| 0| 2| 2| 2| 0| 2| 7| 0| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + A A + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X 4 3 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X 3 4 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + A A + + + + + A + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Parasite Metazoan | 2 X 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + A + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + A A + + + + + A + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X X X X X|
Clear Cell Focus | X X|
Developmental Malformation | X |
Eosinophilic Focus | X |
Fatty Change | |
Granuloma | |
Hepatodiaphragmatic Nodule | X X|
Mixed Cell Focus | X |
Necrosis, Focal | 3 |
Bile Duct, Hyperplasia | 3 4 2 1 2 4 2 3 2|
Lymphatic, Angiectasis, Focal | |
__________________________________________________________________________|
Mesentery | + + + |
Accessory Spleen | |
Fibrosis | 3 |
Artery, Inflammation, Chronic | |
Artery, Thrombosis | |
Fat, Necrosis | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis, Focal | 2 |
Inflammation, Chronic, Focal | |
Acinus, Atrophy | 4 2 2 2 1 2 4 2 2 2 4 2 3 2|
Artery, Hypertrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Ulcer | 4 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 5| 3| 7| 2| 7| 1| 4| 7| 2| 4| 7| 4| 7| 7| 4| 4| 6| 7| 4| 3| 7| 4| 4| 7|
DAY ON TEST | 5| 1| 8| 3| 7| 2| 8| 6| 2| 7| 6| 3| 3| 3| 3| 6| 6| 8| 3| 6| 5| 3| 6| 6| 3|
| 3| 8| 6| 0| 5| 9| 7| 3| 9| 6| 2| 0| 9| 0| 0| 2| 2| 2| 0| 2| 7| 0| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperkeratosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 3 3 2 3 4 2 1 2 2 2 2 2|
Hypertrophy | |
Inflammation, Chronic, Focal | 2 |
Mineralization | 2 |
Artery, Inflammation, Chronic | |
Atrium, Dilatation | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 2 2 1 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 1 2 1 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Depletion Cellular | 2 |
Dilatation | |
Fibrosis | 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | |
Ectasia | 4 |
Inflammation, Chronic, Focal | 2 2 |
Inflammation, Chronic | 2 2 2 1 2 3 2 1 3 3 |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 5| 3| 7| 2| 7| 1| 4| 7| 2| 4| 7| 4| 7| 7| 4| 4| 6| 7| 4| 3| 7| 4| 4| 7|
DAY ON TEST | 5| 1| 8| 3| 7| 2| 8| 6| 2| 7| 6| 3| 3| 3| 3| 6| 6| 8| 3| 6| 5| 3| 6| 6| 3|
| 3| 8| 6| 0| 5| 9| 7| 3| 9| 6| 2| 0| 9| 0| 0| 2| 2| 2| 0| 2| 7| 0| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Metaplasia, Squamous | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 3 2 4|
Hyperplasia, Focal | |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 4 4 3 3 3 4 4 3 4 4|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 4 4 |
Myelofibrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Lymphatic, Angiectasis | |
Pancreatic, Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 3 3 2 |
Infiltration Cellular, Plasma Cell | 4 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Depletion Lymphoid | |
Giant Cell | 1 1 |
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 3 2 |
Fibrosis | 4 4 4 1 |
Hemorrhage | 4 |
Infarct | |
Inflammation, Acute | |
Necrosis, Focal | 2 |
Pigmentation, Hemosiderin | 3 4 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 4 2 2 |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 5| 3| 7| 2| 7| 1| 4| 7| 2| 4| 7| 4| 7| 7| 4| 4| 6| 7| 4| 3| 7| 4| 4| 7|
DAY ON TEST | 5| 1| 8| 3| 7| 2| 8| 6| 2| 7| 6| 3| 3| 3| 3| 6| 6| 8| 3| 6| 5| 3| 6| 6| 3|
| 3| 8| 6| 0| 5| 9| 7| 3| 9| 6| 2| 0| 9| 0| 0| 2| 2| 2| 0| 2| 7| 0| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphatic, Angiectasis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + M + + M + + + + + + + + + + + + + + M|
Lactation | 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Fibrosis, Focal | |
Ulcer | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Hemorrhage | 3 |
Meninges, Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Infiltration Cellular, Focal, | |
Histiocyte | |
Peribronchial, Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 X 3 4 4 |
Inflammation, Acute | 3 3 4 |
Inflammation, Chronic, Focal | 4 |
Inflammation, Chronic | 2 2 2 2 3 2 2 2 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + A + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 6| 5| 3| 7| 2| 7| 1| 4| 7| 2| 4| 7| 4| 7| 7| 4| 4| 6| 7| 4| 3| 7| 4| 4| 7|
DAY ON TEST | 5| 1| 8| 3| 7| 2| 8| 6| 2| 7| 6| 3| 3| 3| 3| 6| 6| 8| 3| 6| 5| 3| 6| 6| 3|
| 3| 8| 6| 0| 5| 9| 7| 3| 9| 6| 2| 0| 9| 0| 0| 2| 2| 2| 0| 2| 7| 0| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Autolysis | 3 |
Cyst | |
Nephropathy | 1 2 1 3 2 1 2 2 3 2 2 1 2 2 3 1 2 1 2 4|
Pelvis, Epithelium, Hyperplasia | 2 |
Renal Tubule, Pigmentation, Bile | |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + A A + + + A + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 1| 7| 7| 2| 6| 7| 7| 7| 7| 1| 6| 6| 5| 7| 4| 7| 7| 7| 6| 7| 4| 7| 7| 7|
DAY ON TEST | 7| 8| 2| 2| 7| 7| 3| 2| 2| 2| 8| 8| 7| 9| 3| 6| 2| 2| 2| 8| 3| 6| 2| 3| 3|
| 6| 5| 9| 9| 6| 8| 0| 9| 9| 9| 0| 6| 5| 8| 0| 3| 9| 9| 9| 2| 0| 3| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 3 2 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 3 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + A + + + + + + + + + + + A + +|
Hyperplasia, Lymphoid | 3 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + A + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 4 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Developmental Malformation | X |
Eosinophilic Focus | X X |
Fatty Change | 2 1 1 |
Granuloma | |
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 3 3 3 2 3 1 2 4 2 2|
Lymphatic, Angiectasis, Focal | 2 3 2 |
__________________________________________________________________________|
Mesentery | + + + + +|
Accessory Spleen | |
Fibrosis | |
Artery, Inflammation, Chronic | |
Artery, Thrombosis | |
Fat, Necrosis | 3 4 4 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis, Focal | |
Inflammation, Chronic, Focal | |
Acinus, Atrophy | 3 2 4 2 2 |
Artery, Hypertrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Ulcer | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 1| 7| 7| 2| 6| 7| 7| 7| 7| 1| 6| 6| 5| 7| 4| 7| 7| 7| 6| 7| 4| 7| 7| 7|
DAY ON TEST | 7| 8| 2| 2| 7| 7| 3| 2| 2| 2| 8| 8| 7| 9| 3| 6| 2| 2| 2| 8| 3| 6| 2| 3| 3|
| 6| 5| 9| 9| 6| 8| 0| 9| 9| 9| 0| 6| 5| 8| 0| 3| 9| 9| 9| 2| 0| 3| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperkeratosis, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 1 3 2 2 1 1 2 1 2 2 1 2 1 2 4|
Hypertrophy | |
Inflammation, Chronic, Focal | 2 |
Mineralization | |
Artery, Inflammation, Chronic | 3 |
Atrium, Dilatation | 4 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 2 1 1 1 4 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 3 1 2 3 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 4 4 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Depletion Cellular | 3 3 |
Dilatation | 3 |
Fibrosis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Cyst | X X |
Ectasia | |
Inflammation, Chronic, Focal | 1 2 |
Inflammation, Chronic | 2 2 3 3|
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 1| 7| 7| 2| 6| 7| 7| 7| 7| 1| 6| 6| 5| 7| 4| 7| 7| 7| 6| 7| 4| 7| 7| 7|
DAY ON TEST | 7| 8| 2| 2| 7| 7| 3| 2| 2| 2| 8| 8| 7| 9| 3| 6| 2| 2| 2| 8| 3| 6| 2| 3| 3|
| 6| 5| 9| 9| 6| 8| 0| 9| 9| 9| 0| 6| 5| 8| 0| 3| 9| 9| 9| 2| 0| 3| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Metaplasia, Squamous | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 3 2 3 2 3 3 |
Hyperplasia, Focal | |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 4 4 4 3 4 2 4 4 2 4 3 4 4 3 4|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 4 2 4 3 4 4 2 3 2 4 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Lymphatic, Angiectasis | 4 |
Pancreatic, Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Congestion | 2 |
Infiltration Cellular, Plasma Cell | |
Lymphatic, Angiectasis | 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 4 |
Congestion | 2 |
Depletion Lymphoid | 2 |
Giant Cell | 2 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 4 2 3 2 |
Fibrosis | 3 1 1 2 1 |
Hemorrhage | |
Infarct | |
Inflammation, Acute | |
Necrosis, Focal | |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
Congestion | 3 |
Depletion Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 1| 7| 7| 2| 6| 7| 7| 7| 7| 1| 6| 6| 5| 7| 4| 7| 7| 7| 6| 7| 4| 7| 7| 7|
DAY ON TEST | 7| 8| 2| 2| 7| 7| 3| 2| 2| 2| 8| 8| 7| 9| 3| 6| 2| 2| 2| 8| 3| 6| 2| 3| 3|
| 6| 5| 9| 9| 6| 8| 0| 9| 9| 9| 0| 6| 5| 8| 0| 3| 9| 9| 9| 2| 0| 3| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphatic, Angiectasis | 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + M M + + + + + + + + + + +|
Lactation | 2 2 2 3 2 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Fibrosis, Focal | 4 |
Ulcer | 2 |
Subcutaneous Tissue, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage | 1 |
Meninges, Hemorrhage | 2|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 3 |
Infiltration Cellular, Focal, | |
Histiocyte | 3 |
Peribronchial, Inflammation, Chronic | 2 2 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 4 4 3 |
Inflammation, Acute | 4 3 3 2 |
Inflammation, Chronic, Focal | 2 2 |
Inflammation, Chronic | 2 3 2 3 2 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + +|
Cataract | 2 2 2|
Retina, Degeneration | 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + A + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
_____________________________________________________________________________________________________________________
| 2| 1| 7| 7| 2| 6| 7| 7| 7| 7| 1| 6| 6| 5| 7| 4| 7| 7| 7| 6| 7| 4| 7| 7| 7|
DAY ON TEST | 7| 8| 2| 2| 7| 7| 3| 2| 2| 2| 8| 8| 7| 9| 3| 6| 2| 2| 2| 8| 3| 6| 2| 3| 3|
| 6| 5| 9| 9| 6| 8| 0| 9| 9| 9| 0| 6| 5| 8| 0| 3| 9| 9| 9| 2| 0| 3| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Autolysis | |
Cyst | X |
Nephropathy | 3 3 1 2 2 1 3 2 3 2 2 1 2 1 2 1 2 1 2 4|
Pelvis, Epithelium, Hyperplasia | |
Renal Tubule, Pigmentation, Bile | 3 4 |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 2| 7| 2| 7| 7| 2| 6| 7| 7| 2| 7| 2| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 6| 9| 7| 2| 7| 2| 3| 7| 3| 3| 3| 7| 2| 7| 2| 2| | |
| 9| 9| 9| 9| 2| 0| 5| 9| 5| 9| 0| 6| 9| 0| 0| 5| 9| 6| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1000 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 66 |
Parasite Metazoan | 3 | 9 2.9|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 69 |
Parasite Metazoan | 2 2 X 4 X | 12 3.1|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 63 |
Hyperplasia, Lymphoid | | 1 3.0|
Parasite Metazoan | | 3 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 64 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis, Focal | 3 3 | 5 3.2|
Basophilic Focus | X X X X X X X X X X X X | 39 |
Clear Cell Focus | X X | 6 |
Developmental Malformation | X X X X X | 7 |
Eosinophilic Focus | X | 4 |
Fatty Change | 3 2 1 | 6 1.7|
Granuloma | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | X X | 4 |
Mixed Cell Focus | | 1 |
Necrosis, Focal | | 1 3.0|
Bile Duct, Hyperplasia | 2 3 4 | 22 2.6|
Lymphatic, Angiectasis, Focal | | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 14 |
Accessory Spleen | X | 1 |
Fibrosis | | 1 3.0|
Artery, Inflammation, Chronic | 4 | 1 4.0|
Artery, Thrombosis | X | 1 |
Fat, Necrosis | 3 4 2 3 | 11 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + M + + + + | 69 |
Autolysis, Focal | | 1 2.0|
Inflammation, Chronic, Focal | 1 | 1 1.0|
Acinus, Atrophy | 3 2 3 4 2 | 24 2.5|
Artery, Hypertrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 2| 7| 2| 7| 7| 2| 6| 7| 7| 2| 7| 2| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 6| 9| 7| 2| 7| 2| 3| 7| 3| 3| 3| 7| 2| 7| 2| 2| | |
| 9| 9| 9| 9| 2| 0| 5| 9| 5| 9| 0| 6| 9| 0| 0| 5| 9| 6| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1000 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Erosion | 2 | 3 2.3|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hyperkeratosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy | 3 2 2 1 3 4 4 1 2 2 1 1 2 1 | 45 2.1|
Hypertrophy | 3 | 1 3.0|
Inflammation, Chronic, Focal | 1 | 3 1.7|
Mineralization | | 1 2.0|
Artery, Inflammation, Chronic | | 1 3.0|
Atrium, Dilatation | 4 | 2 4.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 69 |
Cytoplasmic Alteration, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia, Focal | 1 2 1 3 3 | 22 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + | 69 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + M + M + + + + + + M M + + + | 63 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | X X | 2 |
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 3 2 | 16 2.0|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
C-Cell, Hyperplasia | 2 3 | 7 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 05150-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYLPHENIDATE HYDROCHLORIDE Date: 04/23/97
Route: DOSED FEED Time: 11:13:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 2| 7| 2| 7| 7| 2| 6| 7| 7| 2| 7| 2| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 6| 9| 7| 2| 7| 2| 3| 7| 3| 3| 3| 7| 2| 7| 2| 2| | |
| 9| 9| 9| 9| 2| 0| 5| 9| 5| 9| 0| 6| 9| 0| 0| 5| 9| 6| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1000 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | | 1 3.0|
Depletion Cellular | 3 3 2 | 6 2.7|
Dilatation | | 1 3.0|
Fibrosis | | 1 2.0|
_________________