TDMS Study 05155-04 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
P-NITROBENZOIC ACID
NTP Experiment-Test: 05155-04 Report: PEIRPT03
Study Type: CHRONIC Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
Facility: Southern Research Institute
Chemical CAS #: 62-23-7
Lock Date: 02/19/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 9 8 12 10
Natural Death 3 5 4 8
Accidently Killed 1 2
Survivors
Terminal Sacrifice 38 36 33 30
Missing 1
Animals Examined Microscopically 60 59 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (60) (58) (57) (58)
Dilatation 1 (2%)
Inflammation, Subacute 1 (2%)
Intestine Small, Jejunum (59) (56) (57) (56)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Peyer's Patch, Necrosis 1 (2%)
Liver (60) (59) (60) (60)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Basophilic Focus 1 (2%) 5 (8%) 1 (2%) 2 (3%)
Clear Cell Focus 1 (2%)
Developmental Malformation 1 (2%)
Eosinophilic Focus 4 (7%) 6 (10%) 6 (10%) 2 (3%)
Fatty Change, Focal 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 3 (5%) 1 (2%) 2 (3%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Subacute 3 (5%) 4 (7%)
Karyomegaly 1 (2%)
Mineralization 1 (2%) 1 (2%)
Mixed Cell Focus 3 (5%) 3 (5%) 1 (2%)
Necrosis 2 (3%) 3 (5%) 2 (3%) 2 (3%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 3 (5%) 2 (3%) 1 (2%) 1 (2%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Hepatocyte, Hypertrophy, Diffuse 1 (2%)
Mesentery (5) (8) (6) (7)
Cyst 1 (20%)
Inflammation, Subacute 2 (25%) 1 (17%) 1 (14%)
Pigmentation, Hemosiderin 1 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Polyarteritis 1 (13%)
Fat, Hemorrhage 1 (20%) 1 (14%)
Fat, Inflammation, Granulomatous 1 (20%)
Fat, Inflammation, Subacute 1 (14%)
Fat, Inflammation, Suppurative 1 (17%)
Fat, Necrosis 3 (60%) 4 (50%) 4 (67%) 2 (29%)
Pancreas (60) (57) (59) (59)
Basophilic Focus 1 (2%)
Congestion 1 (2%)
Edema 1 (2%) 1 (2%) 2 (3%)
Inflammation, Suppurative 1 (2%)
Acinus, Atrophy 1 (2%) 1 (2%) 3 (5%)
Acinus, Depletion Secretory 1 (2%) 2 (4%) 3 (5%) 3 (5%)
Duct, Cyst 2 (3%) 1 (2%) 2 (3%) 3 (5%)
Duct, Degeneration 1 (2%)
Duct, Inflammation, Chronic 1 (2%)
Salivary Glands (60) (59) (60) (60)
Cytoplasmic Alteration 1 (2%)
Stomach, Forestomach (60) (59) (59) (59)
Diverticulum 1 (2%)
Hyperplasia 7 (12%) 5 (8%) 4 (7%) 1 (2%)
Inflammation, Subacute 2 (3%) 3 (5%) 1 (2%)
Polyarteritis 1 (2%)
Ulcer 1 (2%)
Stomach, Glandular (59) (58) (59) (59)
Cyst 1 (2%) 3 (5%) 4 (7%) 1 (2%)
Erosion 2 (3%) 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic 1 (2%)
Polyarteritis 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (59) (60) (60)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Inflammation, Subacute 1 (2%)
Coronary Artery, Amyloid Deposition 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (58) (60) (60)
Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%) 2 (3%) 2 (3%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hypertrophy 3 (5%) 2 (3%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Spindle Cell, Hyperplasia 1 (2%)
X-Zone, Vacuolization Cytoplasmic 2 (3%) 5 (9%) 1 (2%) 2 (3%)
Adrenal Medulla (59) (58) (60) (60)
Hyperplasia 2 (3%) 1 (2%)
Islets, Pancreatic (60) (59) (59) (60)
Hyperplasia 1 (2%)
Pituitary Gland (58) (58) (58) (58)
Pars Distalis, Angiectasis 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Cyst 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 11 (19%) 10 (17%) 14 (24%) 11 (19%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (60) (59) (60) (60)
C-Cell, Hyperplasia 1 (2%)
Follicle, Cyst 1 (2%) 1 (2%) 3 (5%) 2 (3%)
Follicle, Degeneration 1 (2%)
Follicular Cell, Hyperplasia 17 (28%) 14 (24%) 24 (40%) 8 (13%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (60) (59) (60) (59)
Inflammation, Subacute 1 (2%)
Duct, Cyst 3 (5%) 9 (15%) 11 (18%) 11 (19%)
Ovary (60) (58) (59) (58)
Abscess 2 (3%) 2 (3%) 6 (10%)
Angiectasis 2 (3%)
Atrophy 1 (2%)
Cyst 17 (28%) 13 (22%) 18 (31%) 15 (26%)
Hemorrhage 5 (9%)
Inflammation, Subacute 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Follicle, Hemorrhage 1 (2%)
Oviduct (1)
Cyst 1 (100%)
Uterus (60) (59) (60) (60)
Angiectasis 1 (2%) 1 (2%)
Atrophy 1 (2%) 2 (3%)
Cyst 1 (2%) 2 (3%)
Dilatation 7 (12%) 11 (19%) 8 (13%) 6 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hemorrhage 3 (5%) 1 (2%)
Hyperplasia, Cystic 51 (85%) 55 (93%) 57 (95%) 46 (77%)
Inflammation, Subacute 1 (2%)
Thrombosis 1 (2%)
Vagina (1) (1)
Inflammation, Granulomatous 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (59) (58) (60)
Atrophy 1 (2%)
Hypercellularity 5 (8%) 1 (2%) 1 (2%) 4 (7%)
Myeloid Cell, Depletion Cellular 1 (2%)
Lymph Node (8) (10) (15) (15)
Axillary, Hyperplasia, Lymphoid 1 (10%)
Iliac, Hyperplasia, Lymphoid 2 (25%) 3 (20%) 3 (20%)
Inguinal, Hyperplasia, Lymphoid 1 (13%) 3 (20%)
Mediastinal, Edema 1 (7%)
Mediastinal, Hyperplasia, Lymphoid 3 (38%) 2 (20%) 1 (7%) 1 (7%)
Mediastinal, Inflammation, Subacute 2 (13%)
Pancreatic, Hyperplasia, Lymphoid 1 (7%)
Renal, Hyperplasia 1 (13%)
Renal, Hyperplasia, Lymphoid 4 (50%) 2 (20%) 3 (20%)
Renal, Inflammation, Subacute 1 (7%)
Lymph Node, Mandibular (60) (59) (60) (59)
Angiectasis 2 (3%)
Cyst 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (3%)
Infiltration Cellular, Mast Cell 1 (2%) 1 (2%)
Lymph Node, Mesenteric (59) (59) (58) (58)
Angiectasis 3 (5%) 4 (7%) 5 (9%) 5 (9%)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 2 (3%) 1 (2%) 1 (2%) 2 (3%)
Necrosis 1 (2%)
Spleen (60) (59) (59) (60)
Atrophy 2 (3%)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 12 (20%) 18 (31%) 15 (25%) 16 (27%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 13 (22%) 12 (20%) 9 (15%) 13 (22%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%) 1 (2%)
Thymus (60) (58) (58) (56)
Atrophy 1 (2%) 1 (2%) 4 (7%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (59) (60) (59)
Hyperplasia, Lobular 1 (2%)
Duct, Cyst 1 (2%) 2 (3%)
Skin (60) (59) (60) (60)
Inflammation, Suppurative 1 (2%)
Parakeratosis 1 (2%)
Dermis, Inflammation, Subacute 2 (3%) 3 (5%) 2 (3%) 3 (5%)
Dermis, Subcutaneous Tissue, Inflammation,
Subacute 1 (2%)
Epidermis, Necrosis 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Subcutaneous Tissue, Inflammation, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (59) (59) (60)
Osteopetrosis 1 (2%)
Cranium, Fibrous Osteodystrophy 3 (5%) 1 (2%)
Femur, Fibrous Osteodystrophy 2 (3%) 2 (3%) 3 (5%) 5 (8%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (59) (60) (60)
Compression 1 (2%) 4 (7%)
Cyst 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Meninges, Infiltration Cellular 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (59) (60) (60)
Congestion 1 (2%)
Edema 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Infiltration Cellular, Histiocyte 2 (3%) 2 (3%)
Inflammation, Subacute 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (5%) 3 (5%) 1 (2%)
Mediastinum, Inflammation, Subacute 1 (2%)
Nose (60) (59) (58) (60)
Glands, Cyst 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Lumen, Fungus 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1)
Atrophy 1 (100%)
Cataract 1 (50%)
Inflammation, Subacute 1 (50%)
Cornea, Inflammation, Subacute 1 (50%)
Harderian Gland (3) (2)
Inflammation, Chronic 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (59) (60) (60)
Fibrosis 1 (2%)
Glomerulosclerosis 4 (7%) 3 (5%) 1 (2%)
Infarct 2 (3%) 1 (2%)
Infiltration Cellular, Lymphocyte 3 (5%) 1 (2%) 4 (7%) 2 (3%)
Inflammation, Subacute 1 (2%) 1 (2%)
Metaplasia, Osseous 2 (3%) 2 (3%)
Mineralization 17 (28%) 8 (14%) 8 (13%) 5 (8%)
Polyarteritis 1 (2%)
Capsule, Fibrosis 1 (2%)
Glomerulus, Amyloid Deposition 2 (3%)
Renal Tubule, Casts 4 (7%) 3 (5%) 2 (3%) 4 (7%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Dilatation 1 (2%) 1 (2%) 4 (7%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Pigmentation 1 (2%)
Renal Tubule, Regeneration 22 (37%) 14 (24%) 15 (25%) 10 (17%)
Urinary Bladder (60) (59) (59) (60)
Dilatation 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 9 4 10 2
Natural Death 2 9 1 2
Accidently Killed 1 2
Survivors
Terminal Sacrifice 39 36 39 44
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (58) (55) (60) (58)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Jejunum (60) (53) (59) (56)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (60) (60) (60) (58)
Basophilic Focus 1 (2%) 4 (7%) 5 (9%)
Clear Cell Focus 4 (7%) 6 (10%) 5 (8%) 2 (3%)
Cytologic Alterations 1 (2%)
Eosinophilic Focus 4 (7%) 17 (28%) 5 (8%) 4 (7%)
Hematopoietic Cell Proliferation 2 (3%)
Inflammation, Subacute 1 (2%) 2 (3%)
Karyomegaly 1 (2%)
Mixed Cell Focus 7 (12%) 5 (8%) 5 (8%) 3 (5%)
Necrosis 4 (7%) 1 (2%) 1 (2%)
Regeneration 1 (2%)
Vacuolization Cytoplasmic 4 (7%) 3 (5%) 6 (10%) 4 (7%)
Hepatocyte, Hypertrophy, Focal 1 (2%)
Mesentery (3) (1) (2) (4)
Fat, Inflammation, Granulomatous 1 (50%)
Fat, Necrosis 2 (67%) 1 (100%) 1 (50%) 4 (100%)
Pancreas (60) (58) (60) (57)
Edema 1 (2%)
Inflammation, Chronic 1 (2%)
Acinus, Atrophy 1 (2%) 1 (2%) 2 (3%)
Acinus, Depletion Secretory 1 (2%) 1 (2%)
Duct, Cyst 1 (2%) 1 (2%) 1 (2%)
Salivary Glands (60) (59) (60) (60)
Acinus, Atrophy 1 (2%)
Duct, Cyst 1 (2%)
Stomach, Forestomach (60) (57) (60) (57)
Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperplasia 6 (10%) 4 (7%)
Inflammation, Subacute 1 (2%) 3 (5%)
Ulcer 1 (2%)
Stomach, Glandular (60) (57) (60) (57)
Cyst 1 (2%) 2 (3%) 1 (2%)
Mineralization 1 (2%)
Ulcer 2 (3%)
Tooth (2) (2) (2)
Dysplasia 1 (50%) 1 (50%)
Inflammation, Chronic 1 (50%) 1 (50%)
Inflammation, Subacute 2 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (59) (60) (60)
Cardiomyopathy 1 (2%)
Fibrosis 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
Artery, Inflammation, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (59) (60) (59)
Accessory Adrenal Cortical Nodule 1 (2%) 2 (3%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Hypertrophy 15 (25%) 18 (31%) 17 (28%) 17 (29%)
Spindle Cell, Hyperplasia 1 (2%) 1 (2%)
Islets, Pancreatic (60) (59) (60) (58)
Hyperplasia 1 (2%) 3 (5%)
Pituitary Gland (56) (55) (60) (56)
Pars Distalis, Cyst 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Pars Distalis, Hyperplasia 1 (2%)
Thyroid Gland (60) (59) (60) (59)
Follicle, Cyst 2 (3%) 1 (2%) 3 (5%)
Follicle, Degeneration 1 (2%)
Follicular Cell, Hyperplasia 15 (25%) 12 (20%) 8 (13%) 9 (15%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (2)
Dilatation 1 (100%) 1 (50%)
Epididymis (60) (59) (60) (60)
Cyst, Multiple 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Preputial Gland (60) (59) (60) (60)
Abscess 2 (3%) 1 (2%) 2 (3%)
Atrophy 1 (2%) 1 (2%)
Cyst 1 (2%) 1 (2%)
Infiltration Cellular, Subacute 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Subacute 11 (18%) 2 (3%) 10 (17%) 5 (8%)
Duct, Cyst 33 (55%) 37 (63%) 39 (65%) 30 (50%)
Prostate (60) (59) (60) (60)
Atrophy 1 (2%)
Inflammation, Subacute 1 (2%)
Polyarteritis 1 (2%)
Seminal Vesicle (60) (59) (60) (60)
Atrophy 1 (2%) 1 (2%) 2 (3%) 1 (2%)
Dilatation 1 (2%) 6 (10%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (59) (60) (60)
Congestion 1 (2%)
Hypercellularity 2 (3%) 1 (2%) 2 (3%) 3 (5%)
Lymph Node (4) (1) (4) (4)
Axillary, Hyperplasia, Lymphoid 1 (25%) 1 (25%)
Bronchial, Hyperplasia, Lymphoid 2 (50%)
Inguinal, Angiectasis 1 (25%)
Inguinal, Hyperplasia, Lymphoid 1 (25%) 1 (25%) 1 (25%)
Mediastinal, Hyperplasia, Lymphoid 1 (25%)
Pancreatic, Mineralization 1 (25%)
Renal, Hyperplasia, Lymphoid 1 (100%)
Lymph Node, Mandibular (59) (57) (60) (60)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 3 (5%)
Infiltration Cellular, Mast Cell 1 (2%)
Lymph Node, Mesenteric (60) (59) (60) (57)
Angiectasis 18 (30%) 21 (36%) 20 (33%) 17 (30%)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 2 (3%) 1 (2%)
Hyperplasia, Lymphoid 2 (3%) 2 (3%) 2 (3%)
Spleen (60) (59) (60) (59)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Atrophy 1 (2%) 2 (3%) 3 (5%) 5 (8%)
Hematopoietic Cell Proliferation 12 (20%) 9 (15%) 11 (18%) 6 (10%)
Hyperplasia, Lymphoid 1 (2%) 3 (5%) 2 (3%)
Necrosis 1 (2%)
Thymus (55) (56) (57) (57)
Atrophy 4 (7%) 1 (2%) 2 (4%) 1 (2%)
Cyst 1 (2%) 4 (7%) 1 (2%) 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (59) (60) (60)
Ulcer 1 (2%) 1 (2%)
Dermis, Inflammation, Chronic 1 (2%)
Dermis, Inflammation, Subacute 1 (2%) 1 (2%) 1 (2%)
Pinna, Inflammation, Subacute 1 (2%)
Subcutaneous Tissue, Abscess 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Cranium, Hyperostosis 1 (2%)
Femur, Fibrous Osteodystrophy 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Congestion 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (2%) 3 (5%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Subacute 3 (5%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (3%) 8 (13%) 8 (13%) 8 (13%)
Bronchiole, Hyperplasia 1 (2%)
Nose (60) (59) (59) (60)
Congestion 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Glands, Inflammation, Subacute 1 (2%)
Lumen, Hemorrhage 1 (2%)
Nasolacrimal Duct, Ectasia 1 (2%)
Nasolacrimal Duct, Inflammation, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (2) (1)
Cataract 1 (33%)
Retrobulbar, Hemorrhage 1 (33%) 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (59) (60) (58)
Fibrosis 4 (7%) 2 (3%) 3 (5%) 2 (3%)
Glomerulosclerosis 2 (3%) 5 (8%) 6 (10%) 2 (3%)
Hemorrhage 1 (2%)
Hydronephrosis 1 (2%)
Infarct 7 (12%) 4 (7%) 5 (8%) 3 (5%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Subacute 2 (3%)
Metaplasia, Osseous 1 (2%) 1 (2%) 1 (2%)
Mineralization 50 (83%) 37 (63%) 28 (47%) 35 (60%)
Cortex, Cyst 11 (18%) 6 (10%) 5 (8%) 3 (5%)
Renal Tubule, Casts 7 (12%) 8 (14%) 7 (12%) 3 (5%)
Renal Tubule, Pigmentation 1 (2%)
Renal Tubule, Regeneration 50 (83%) 43 (73%) 42 (70%) 35 (60%)
Urethra (1)
Bulbourethral Gland, Hemorrhage 1 (100%)
Urinary Bladder (60) (60) (60) (58)
Dilatation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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