TDMS Study 05155-04 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
P-NITROBENZOIC ACID
NTP Experiment-Test: 05155-04 Report: PEIRPT05
Study Type: CHRONIC Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
Facility: Southern Research Institute
Chemical CAS #: 62-23-7
Lock Date: 02/19/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 9 8 12 10
Natural Death 3 5 4 8
Accidently Killed 1 2
Survivors
Terminal Sacrifice 38 36 33 30
Missing 1
Animals Examined Microscopically 60 59 60 60
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ALIMENTARY SYSTEM
Gallbladder (60) (58) (57) (58)
Histiocytic Sarcoma 1 (2%)
Intestine Small, Duodenum (59) (56) (57) (56)
Polyp Adenomatous 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Intestine Small, Jejunum (59) (56) (57) (56)
Adenocarcinoma 1 (2%)
Intestine Small, Ileum (59) (56) (57) (55)
Liver (60) (59) (60) (60)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 5 (8%) 5 (8%) 4 (7%) 6 (10%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%)
Hepatocellular Adenoma 8 (13%) 11 (19%) 15 (25%) 5 (8%)
Hepatocellular Adenoma, Multiple 3 (5%) 4 (7%) 2 (3%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (3%) 3 (5%)
Mesentery (5) (8) (6) (7)
Histiocytic Sarcoma 1 (13%)
Osteosarcoma, Metastatic, Bone 1 (14%)
Sarcoma 1 (14%)
Pancreas (60) (57) (59) (59)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Salivary Glands (60) (59) (60) (60)
Stomach, Forestomach (60) (59) (59) (59)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Squamous Cell Papilloma 1 (2%) 2 (3%) 2 (3%) 1 (2%)
Stomach, Glandular (59) (58) (59) (59)
Histiocytic Sarcoma 1 (2%)
Tooth (1)
Page 2
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Histiocytic Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (59) (60) (60)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (58) (60) (60)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Adrenal Medulla (59) (58) (60) (60)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (60) (59) (59) (60)
Carcinoma 1 (2%)
Pituitary Gland (58) (58) (58) (58)
Pars Distalis, Adenoma 7 (12%) 6 (10%) 9 (16%) 5 (9%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (60) (59) (60) (60)
Follicular Cell, Adenoma 1 (2%) 2 (3%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (60) (58) (59) (58)
Cystadenoma 1 (2%) 2 (3%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 2 (3%) 1 (2%)
Luteoma 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Uterus (60) (59) (60) (60)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (3%) 1 (2%)
Leiomyoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 1 (2%) 2 (3%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Sarcoma Stromal 1 (2%)
Page 3
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Vagina (1) (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (59) (58) (60)
Hemangiosarcoma 1 (2%) 1 (2%) 2 (3%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymph Node (8) (10) (15) (15)
Axillary, Fibrosarcoma, Metastatic, Skin 1 (7%)
Iliac, Histiocytic Sarcoma 1 (10%) 1 (7%)
Inguinal, Histiocytic Sarcoma 1 (10%) 1 (7%)
Mediastinal, Histiocytic Sarcoma 1 (10%)
Pancreatic, Histiocytic Sarcoma 1 (7%)
Pancreatic, Sarcoma, Metastatic, Mesentery 1 (7%)
Renal, Hemangiosarcoma 1 (7%)
Renal, Histiocytic Sarcoma 1 (10%) 1 (7%)
Lymph Node, Mandibular (60) (59) (60) (59)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymph Node, Mesenteric (59) (59) (58) (58)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Spleen (60) (59) (59) (60)
Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Thymus (60) (58) (58) (56)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (59) (60) (59)
Adenoma 1 (2%) 1 (2%)
Skin (60) (59) (60) (60)
Schwannoma NOS 1 (2%)
Subcutaneous Tissue, Basal Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
Subcutaneous Tissue, Thymoma Malignant,
Metastatic, Thymus 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (59) (59) (60)
Femur, Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1) (2) (2)
Fibrosarcoma 2 (100%)
Hemangiosarcoma 1 (100%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (100%)
Sarcoma, Metastatic, Mesentery 1 (50%)
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NERVOUS SYSTEM
Brain (59) (59) (60) (60)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Glioma NOS 1 (2%)
Meninges, Histiocytic Sarcoma 1 (2%) 1 (2%)
Olfactory Lobe, Histiocytic Sarcoma 1 (2%)
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RESPIRATORY SYSTEM
Lung (60) (59) (60) (60)
Alveolar/Bronchiolar Adenoma 3 (5%) 5 (8%) 3 (5%) 8 (13%)
Alveolar/Bronchiolar Carcinoma 4 (7%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 4 (7%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Mediastinum, Hemangiosarcoma, Metastatic,
Spleen 1 (2%)
Nose (60) (59) (58) (60)
Glands, Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (2)
Adenoma 3 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (59) (60) (60)
Histiocytic Sarcoma 2 (3%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Urinary Bladder (60) (59) (59) (60)
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SYSTEMIC LESIONS
Multiple Organs *(60) *(59) *(60) *(60)
Histiocytic Sarcoma 1 (2%) 2 (3%) 3 (5%)
Lymphoma Malignant Lymphocytic 6 (10%) 8 (14%) 7 (12%) 5 (8%)
Lymphoma Malignant Mixed 3 (5%) 3 (5%) 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 37 40 39 33
Total Primary Neoplasms 54 63 67 43
Total Animals with Benign Neoplasms 22 24 27 21
Total Benign Neoplasms 29 35 36 24
Total Animals with Malignant Neoplasms 24 23 24 17
Total Malignant Neoplasms 25 27 30 19
Total Animals with Metastatic Neoplasms 3 4 2 2
Total Metastatic Neoplasm 3 9 4 12
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 9 4 10 2
Natural Death 2 9 1 2
Accidently Killed 1 2
Survivors
Terminal Sacrifice 39 36 39 44
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (58) (55) (60) (58)
Intestine Small, Jejunum (60) (53) (59) (56)
Adenocarcinoma 3 (5%) 1 (2%)
Intestine Small, Ileum (60) (52) (59) (56)
Liver (60) (60) (60) (58)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 6 (10%) 11 (18%) 12 (20%) 4 (7%)
Hepatocellular Carcinoma, Multiple 2 (3%) 4 (7%) 4 (7%) 4 (7%)
Hepatocellular Adenoma 15 (25%) 11 (18%) 6 (10%) 11 (19%)
Hepatocellular Adenoma, Multiple 4 (7%) 8 (13%) 8 (13%) 3 (5%)
Hepatocholangiocarcinoma 1 (2%)
Mesentery (3) (1) (2) (4)
Sarcoma 1 (33%)
Pancreas (60) (58) (60) (57)
Sarcoma, Metastatic, Mesentery 1 (2%)
Stomach, Forestomach (60) (57) (60) (57)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (60) (57) (60) (57)
Carcinoid Tumor NOS 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (59) (60) (59)
Sarcoma, Metastatic, Mesentery 1 (2%)
Adrenal Medulla (60) (59) (60) (59)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (60) (59) (60) (58)
Adenoma 1 (2%)
Pituitary Gland (56) (55) (60) (56)
Pars Distalis, Adenoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (60) (59) (60) (59)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (59) (60) (60)
Prostate (60) (59) (60) (60)
Seminal Vesicle (60) (59) (60) (60)
Testes (60) (59) (60) (60)
Interstitial Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (59) (60) (60)
Hemangioma 1 (2%)
Lymph Node (4) (1) (4) (4)
Lymph Node, Mandibular (59) (57) (60) (60)
Mast Cell Tumor NOS 1 (2%)
Lymph Node, Mesenteric (60) (59) (60) (57)
Spleen (60) (59) (60) (59)
Hemangiosarcoma 4 (7%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (59) (60) (60)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Page 9
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Mast Cell Tumor NOS 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Hemangiosarcoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 3 (5%) 11 (18%) 8 (13%) 7 (12%)
Alveolar/Bronchiolar Adenoma, Multiple 3 (5%) 2 (3%) 2 (3%) 3 (5%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 3 (5%) 2 (3%) 5 (8%)
Hepatocellular Carcinoma, Metastatic, Liver 4 (7%) 2 (3%) 6 (10%) 4 (7%)
Nose (60) (59) (59) (60)
Nasolacrimal Duct, Mast Cell Tumor NOS 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Schwannoma Benign 1 (100%)
Harderian Gland (1) (3) (3) (1)
Adenoma 1 (100%) 3 (100%) 2 (67%) 1 (100%)
Adenoma, Multiple 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (59) (60) (58)
Transitional Epithelium, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Lymphoma Malignant Lymphocytic 2 (3%) 1 (2%) 2 (3%) 2 (3%)
Lymphoma Malignant Mixed 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05155-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 19:10:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 35 41 41 31
Total Primary Neoplasms 51 64 58 42
Total Animals with Benign Neoplasms 22 32 26 23
Total Benign Neoplasms 29 40 31 26
Total Animals with Malignant Neoplasms 18 21 21 14
Total Malignant Neoplasms 22 23 24 16
Total Animals with Metastatic Neoplasms 5 2 6 4
Total Metastatic Neoplasm 7 2 6 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 3
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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