TDMS Study 05155-04 Pathology Tables
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
Facility: Southern Research Institute
Chemical CAS #: 62-23-7
Lock Date: 02/19/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 3| 8| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 5| 5| 5| 5| 5| 5| 5| 6| 9| 3| 5| 9| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | |
Eosinophilic Focus | 2 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Subacute | 2 |
Mixed Cell Focus | 2 |
Necrosis | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Cyst | |
Pigmentation, Hemosiderin | 2 |
Fat, Hemorrhage | |
Fat, Inflammation, Granulomatous | |
Fat, Necrosis | 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Acinus, Atrophy | |
Acinus, Depletion Secretory | |
Duct, Cyst | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Hyperplasia | 3 3 2 2 3|
Inflammation, Subacute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Inflammation, Subacute | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 3| 8| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 5| 5| 5| 5| 5| 5| 5| 6| 9| 3| 5| 9| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 |
Hypertrophy | 2 2 2 |
X-Zone, Vacuolization Cytoplasmic | 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + + + + + + + + + M M M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 3 1 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 4 3 4 1 1 1 1 1 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Angiectasis | |
Cyst | 2 2 2 3 2 2 |
Inflammation, Suppurative | 4 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 2 |
Hemorrhage | 3 2 2 |
Hyperplasia, Cystic | 2 2 3 2 2 2 2 2 2 2 2 3 3 2 3 3 2 2 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 4 3 3|
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hyperplasia, Lymphoid | 2 |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 2 |
Renal, Hyperplasia, Lymphoid | 3 2 3 |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Mast Cell | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 3| 8| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 5| 5| 5| 5| 5| 5| 5| 6| 9| 3| 5| 9| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | 2 |
Hematopoietic Cell Proliferation | 2|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 2 3 3 3 3 3 2|
Hyperplasia, Lymphoid | 3 2 3 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lobular | 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Subacute | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + M + + + + + + + + + + +|
Compression | 3|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia | 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Cyst | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Inflammation, Subacute | |
Cornea, Inflammation, Subacute | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 3| 8| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 5| 5| 5| 5| 5| 5| 5| 6| 9| 3| 5| 9| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | 1 2 3 2|
Infarct | 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Subacute | |
Mineralization | 1 1 1 1 1 1 |
Renal Tubule, Casts | 1 1 3 2|
Renal Tubule, Degeneration | |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Regeneration | 1 1 1 2 1 1 1 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3|
| 5| 5| 5| 3| 5| 5| 5| 8| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 5| 3| 3| 5| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 4 |
Eosinophilic Focus | 1 2 |
Hematopoietic Cell Proliferation | 1|
Inflammation, Subacute | 2|
Mixed Cell Focus | X 3 |
Necrosis | 3 |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Mesentery | + |
Cyst | |
Pigmentation, Hemosiderin | |
Fat, Hemorrhage | |
Fat, Inflammation, Granulomatous | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Acinus, Atrophy | |
Acinus, Depletion Secretory | 3 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3 |
Hyperplasia | 4 2 |
Inflammation, Subacute | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3|
| 5| 5| 5| 3| 5| 5| 5| 8| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 5| 3| 3| 5| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
Hypertrophy | |
X-Zone, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + M + + + M + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Hyperplasia | 2 2 2 3 3 1 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 2 1 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 2 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4|
Angiectasis | |
Cyst | 2 3 2 2 2 2 2 3 2 3 2|
Inflammation, Suppurative | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 3 2 |
Hemorrhage | |
Hyperplasia, Cystic | 2 2 2 2 3 3 2 2 2 2 3 3 3 3 3 3 2 2 2 1 2 2 2 3|
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3|
__________________________________________________________________________|
Lymph Node | + + + +|
Iliac, Hyperplasia, Lymphoid | 3 |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia | 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Mast Cell | 2 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3|
| 5| 5| 5| 3| 5| 5| 5| 8| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 5| 3| 3| 5| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 3 4 3 3|
Hyperplasia, Lymphoid | 2 3 2 2 3 2 2 2 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lobular | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 2 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Cyst | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 |
Inflammation, Subacute | 2 |
Cornea, Inflammation, Subacute | 2 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3|
| 5| 5| 5| 3| 5| 5| 5| 8| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 5| 3| 3| 5| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Infarct | 1 |
Infiltration Cellular, Lymphocyte | 2 2 2 |
Inflammation, Subacute | 2 |
Mineralization | 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Casts | |
Renal Tubule, Degeneration | 2 |
Renal Tubule, Dilatation | |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0.0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Basophilic Focus | | 1 4.0|
Eosinophilic Focus | | 4 1.8|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Subacute | 1 | 3 1.7|
Mixed Cell Focus | | 3 2.5|
Necrosis | 1 | 2 2.0|
Vacuolization Cytoplasmic | 1 | 3 1.7|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Cyst | 2 | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Fat, Hemorrhage | 2 | 1 2.0|
Fat, Inflammation, Granulomatous | | 1 2.0|
Fat, Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Acinus, Atrophy | 2 | 1 2.0|
Acinus, Depletion Secretory | | 1 3.0|
Duct, Cyst | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Diverticulum | | 1 3.0|
Hyperplasia | | 7 2.7|
Inflammation, Subacute | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0.0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation, Subacute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hypertrophy | | 3 2.0|
X-Zone, Vacuolization Cytoplasmic | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Hyperplasia | 2 | 11 2.1|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicle, Cyst | 2 | 1 2.0|
Follicular Cell, Hyperplasia | | 17 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Duct, Cyst | | 3 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Abscess | | 2 4.0|
Angiectasis | 2 2 | 2 2.0|
Cyst | | 17 2.2|
Inflammation, Suppurative | | 1 4.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Dilatation | | 7 2.4|
Hemorrhage | | 3 2.3|
Hyperplasia, Cystic | 2 3 1 2 1 2 2 2 | 51 2.2|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0.0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hypercellularity | | 5 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 8 |
Iliac, Hyperplasia, Lymphoid | | 2 2.5|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 3 2.7|
Renal, Hyperplasia, Lymphoid | | 4 2.5|
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Mast Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + | 59 |
Angiectasis | | 3 2.0|
Cyst | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | | 12 2.8|
Hyperplasia, Lymphoid | 3 | 13 2.4|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Lobular | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Dermis, Inflammation, Subacute | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Femur, Fibrous Osteodystrophy | | 2 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Compression | | 1 3.0|
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0.0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Glands, Cyst | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
Cornea, Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Glomerulosclerosis | | 4 2.0|
Infarct | | 2 1.5|
Infiltration Cellular, Lymphocyte | | 3 2.0|
Inflammation, Subacute | | 1 2.0|
Mineralization | 1 1 | 17 1.0|
Renal Tubule, Casts | | 4 1.8|
Renal Tubule, Degeneration | | 1 2.0|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Regeneration | 1 1 1 1 | 22 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 2| 3| 3| 3| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 0| 3| 3| 0| 3| 8|
| 1| 0| 1| 1| 1| 6| 6| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 0| 1| 1| 1| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + A + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + A + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + A + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + A + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + A + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + A + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 3 4 3 |
Developmental Malformation | |
Eosinophilic Focus | 1 1 2 4 |
Fatty Change, Focal | 2 |
Hematopoietic Cell Proliferation | 2 2 |
Infiltration Cellular, Lymphocyte | 3 |
Mineralization | 3 |
Mixed Cell Focus | 2 |
Necrosis | 4 |
Thrombosis | 3 |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Subacute | 3 |
Polyarteritis | 3 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + +|
Congestion | |
Inflammation, Suppurative | 2 |
Acinus, Depletion Secretory | 2 3 |
Duct, Cyst | 4 |
Duct, Degeneration | 3 |
Duct, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Polyarteritis | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Erosion | 2 |
Hyperplasia | 3 |
Polyarteritis | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 2| 3| 3| 3| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 0| 3| 3| 0| 3| 8|
| 1| 0| 1| 1| 1| 6| 6| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 0| 1| 1| 1| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hypertrophy | 2 |
Spindle Cell, Hyperplasia | |
X-Zone, Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 1 2 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 1 3 2 3 3 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 3 2 2 2|
__________________________________________________________________________|
Ovary | + + + M + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst | 2 3 4 2 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 3 |
Dilatation | 3 3 3 3 3 3 3|
Hemorrhage | 1 |
Hyperplasia, Cystic | 3 2 2 3 3 2 2 2 2 2 3 3 3 2 3 2 3 2 3 2 3|
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 4 |
__________________________________________________________________________|
Lymph Node | + + + |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 2| 3| 3| 3| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 0| 3| 3| 0| 3| 8|
| 1| 0| 1| 1| 1| 6| 6| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 0| 1| 1| 1| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Axillary, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 3 2 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 3 2 3 3 4 2 3 3 2|
Hyperplasia, Lymphoid | 2 2 2 2 3 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Parakeratosis | |
Dermis, Inflammation, Subacute | 1 1 |
Dermis, Subcutaneous Tissue, | |
Inflammation, Subacute | 3 |
Epidermis, Necrosis | |
Subcutaneous Tissue, Edema | 3 |
Subcutaneous Tissue, Inflammation, | |
Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | 3 |
Femur, Fibrous Osteodystrophy | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 |
Infiltration Cellular, Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 2| 3| 3| 3| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 0| 3| 3| 0| 3| 8|
| 1| 0| 1| 1| 1| 6| 6| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 0| 1| 1| 1| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mediastinum, Inflammation, Subacute | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Fungus | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Glomerulosclerosis | |
Infiltration Cellular, Lymphocyte | 2 |
Mineralization | 1 1 1 |
Polyarteritis | 3 |
Renal Tubule, Casts | |
Renal Tubule, Regeneration | 1 1 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 8| 3| 8| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5|
| 5| 5| 5| 1| 1| 1| 8| 1| 1| 5| 1| 8| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Subacute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 3 2 |
Developmental Malformation | X |
Eosinophilic Focus | 4 |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Lymphocyte | |
Mineralization | |
Mixed Cell Focus | 2 2 |
Necrosis | 3 2|
Thrombosis | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Mesentery | + + + + +|
Inflammation, Subacute | 3|
Polyarteritis | |
Fat, Necrosis | 2 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Congestion | 2 |
Inflammation, Suppurative | |
Acinus, Depletion Secretory | |
Duct, Cyst | |
Duct, Degeneration | |
Duct, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 |
Polyarteritis | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2|
Erosion | 2|
Hyperplasia | |
Polyarteritis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 8| 3| 8| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5|
| 5| 5| 5| 1| 1| 1| 8| 1| 1| 5| 1| 8| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Hypertrophy | 1 |
Spindle Cell, Hyperplasia | 3 |
X-Zone, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 1 2 3 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 2 2 2 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4|
Cyst | 2 3 4 2 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Dilatation | 2 3 2|
Hemorrhage | |
Hyperplasia, Cystic | 2 3 3 3 3 2 2 2 3 2 4 2 3 3 3 2 2 2 3 3 3 2 3 2|
Thrombosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 8| 3| 8| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5|
| 5| 5| 5| 1| 1| 1| 8| 1| 1| 5| 1| 8| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Axillary, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 3|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 2 2 3|
Hyperplasia, Lymphoid | 2 3 3 3 2 3 2 |
Necrosis | 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parakeratosis | 2 |
Dermis, Inflammation, Subacute | 1 |
Dermis, Subcutaneous Tissue, | |
Inflammation, Subacute | |
Epidermis, Necrosis | 3 |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Inflammation, | |
Subacute | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | 3 3 |
Femur, Fibrous Osteodystrophy | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Lymphocyte | |
Infiltration Cellular, Histiocyte | 1 |
Alveolar Epithelium, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 8| 3| 8| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5|
| 5| 5| 5| 1| 1| 1| 8| 1| 1| 5| 1| 8| 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mediastinum, Inflammation, Subacute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Fungus | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Glomerulosclerosis | 2 2 3|
Infiltration Cellular, Lymphocyte | |
Mineralization | 1 1 1 1 |
Polyarteritis | |
Renal Tubule, Casts | 2 2 |
Renal Tubule, Regeneration | 1 2 1 1 1 3 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.125% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 58 |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Angiectasis | | 1 3.0|
Basophilic Focus | | 5 3.0|
Developmental Malformation | | 1 |
Eosinophilic Focus | 2 | 6 2.3|
Fatty Change, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | | 3 2.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Mineralization | | 1 3.0|
Mixed Cell Focus | | 3 2.0|
Necrosis | | 3 3.0|
Thrombosis | | 1 3.0|
Vacuolization Cytoplasmic | | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | | 8 |
Inflammation, Subacute | | 2 3.0|
Polyarteritis | | 1 3.0|
Fat, Necrosis | | 4 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 57 |
Congestion | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Acinus, Depletion Secretory | | 2 2.5|
Duct, Cyst | | 1 4.0|
Duct, Degeneration | | 1 3.0|
Duct, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Hyperplasia | 2 | 5 2.0|
Polyarteritis | | 1 3.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.125% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cyst | | 3 2.0|
Erosion | | 2 2.0|
Hyperplasia | | 1 3.0|
Polyarteritis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Hypertrophy | | 2 1.5|
Spindle Cell, Hyperplasia | | 1 3.0|
X-Zone, Vacuolization Cytoplasmic | 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Hyperplasia | | 10 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Follicle, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | | 14 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Duct, Cyst | | 9 2.1|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Abscess | | 2 4.0|
Cyst | 3 2 2 3 | 13 2.7|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Angiectasis | | 1 3.0|
Cyst | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.125% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | 3 | 11 2.8|
Hemorrhage | | 1 1.0|
Hyperplasia, Cystic | 3 3 2 2 2 3 2 2 2 2 | 55 2.5|
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Hypercellularity | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | | 10 |
Axillary, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.5|
Renal, Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Angiectasis | | 2 2.0|
Cyst | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Angiectasis | | 4 2.8|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | | 18 2.6|
Hyperplasia, Lymphoid | | 12 2.4|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Parakeratosis | | 1 2.0|
Dermis, Inflammation, Subacute | | 3 1.0|
Dermis, Subcutaneous Tissue, | | |
Inflammation, Subacute | | 1 3.0|
Epidermis, Necrosis | | 1 3.0|
Subcutaneous Tissue, Edema | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Subacute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.125% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Cranium, Fibrous Osteodystrophy | | 3 3.0|
Femur, Fibrous Osteodystrophy | | 2 2.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Vacuolization Cytoplasmic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Hemorrhage | | 1 1.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Infiltration Cellular, Histiocyte | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Mediastinum, Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Lumen, Fungus | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Fibrosis | | 1 1.0|
Glomerulosclerosis | | 3 2.3|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Mineralization | 1 | 8 1.0|
Polyarteritis | | 1 3.0|
Renal Tubule, Casts | 2 | 3 2.0|
Renal Tubule, Regeneration | | 14 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 0| 8| 3| 3| 3| 3| 6| 3| 5| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| 3|
| 1| 0| 1| 7| 9| 1| 1| 1| 1| 9| 1| 1| 1| 1| 0| 1| 1| 9| 1| 1| 1| 8| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + A + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | 3 2|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 |
Karyomegaly | |
Mineralization | 3 |
Mixed Cell Focus | 2 |
Necrosis | 2 2 |
Vacuolization Cytoplasmic | 3 |
Bile Duct, Cyst | |
Hepatocyte, Hypertrophy, Diffuse | 4 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Subacute | 3 |
Fat, Inflammation, Suppurative | |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Acinus, Atrophy | |
Acinus, Depletion Secretory | 3 |
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 |
Inflammation, Subacute | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 2 |
Erosion | 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 0| 8| 3| 3| 3| 3| 6| 3| 5| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| 3|
| 1| 0| 1| 7| 9| 1| 1| 1| 1| 9| 1| 1| 1| 1| 0| 1| 1| 9| 1| 1| 1| 8| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Hyperplasia | |
Hypertrophy | |
Vacuolization Cytoplasmic | 2 |
X-Zone, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 2 1 2 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicle, Cyst | 3|
Follicular Cell, Hyperplasia | 2 4 1 2 2 2 1 3 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 2 2 2 2 2 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | 3 2 2 4 4 3 |
Follicle, Hemorrhage | |
__________________________________________________________________________|
Oviduct | |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | 3 |
Dilatation | 3 3 2 |
Hyperplasia, Cystic | 3 2 3 2 3 3 3 2 2 3 2 2 2 2 2 1 2 2 3 2 2 3 2 2|
__________________________________________________________________________|
Vagina | + |
Inflammation, Granulomatous | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hypercellularity | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 0| 8| 3| 3| 3| 3| 6| 3| 5| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| 3|
| 1| 0| 1| 7| 9| 1| 1| 1| 1| 9| 1| 1| 1| 1| 0| 1| 1| 9| 1| 1| 1| 8| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hyperplasia, Lymphoid | 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 3 3 3 3 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 2 2 3 3 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Dermis, Inflammation, Subacute | 2 |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
Femur, Fibrous Osteodystrophy | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 |
Meninges, Infiltration Cellular | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 0| 8| 3| 3| 3| 3| 6| 3| 5| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| 3|
| 1| 0| 1| 7| 9| 1| 1| 1| 1| 9| 1| 1| 1| 1| 0| 1| 1| 9| 1| 1| 1| 8| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
Infiltration Cellular, Lymphocyte | 2 |
Metaplasia, Osseous | 2 |
Mineralization | 1 1 1 1 |
Renal Tubule, Casts | 1 |
Renal Tubule, Dilatation | |
Renal Tubule, Regeneration | 1 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 0| 7| 8| 3| 3| 2| 3| 3| 3| 8| 3| 0| 3| 3| 9| 3| 3| 3|
| 1| 1| 1| 1| 1| 1| 4| 7| 8| 0| 1| 1| 0| 1| 1| 1| 9| 1| 7| 1| 1| 0| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 |
Eosinophilic Focus | 3 2 2 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Karyomegaly | |
Mineralization | |
Mixed Cell Focus | |
Necrosis | |
Vacuolization Cytoplasmic | |
Bile Duct, Cyst | |
Hepatocyte, Hypertrophy, Diffuse | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Subacute | |
Fat, Inflammation, Suppurative | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +|
Edema | |
Acinus, Atrophy | 2 |
Acinus, Depletion Secretory | 2 2 |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia | 2 |
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +|
Cyst | 2 |
Erosion | |
Inflammation, Chronic | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 0| 7| 8| 3| 3| 2| 3| 3| 3| 8| 3| 0| 3| 3| 9| 3| 3| 3|
| 1| 1| 1| 1| 1| 1| 4| 7| 8| 0| 1| 1| 0| 1| 1| 1| 9| 1| 7| 1| 1| 0| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Hyperplasia | |
Hypertrophy | 1 |
Vacuolization Cytoplasmic | |
X-Zone, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 2 1 2 1 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | 4 2 |
Follicular Cell, Hyperplasia | 2 1 1 2 2 2 2 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 2 2 2 2 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + A + + + + + +|
Atrophy | |
Cyst | 2 X 2 3 3 2 3 4 1 |
Follicle, Hemorrhage | |
__________________________________________________________________________|
Oviduct | + |
Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | 3 |
Dilatation | 4 3 2|
Hyperplasia, Cystic | 3 2 3 3 1 2 2 3 2 3 2 2 3 2 1 2 2 2 2 3 2 2 3 3|
__________________________________________________________________________|
Vagina | |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + M I + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 0| 7| 8| 3| 3| 2| 3| 3| 3| 8| 3| 0| 3| 3| 9| 3| 3| 3|
| 1| 1| 1| 1| 1| 1| 4| 7| 8| 0| 1| 1| 0| 1| 1| 1| 9| 1| 7| 1| 1| 0| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + I + + + + + + + + A + + + + + +|
Angiectasis | 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 3 2 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 2 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + A + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Dermis, Inflammation, Subacute | 1 |
Subcutaneous Tissue, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + I + + + + + + + + + + + + + + +|
Osteopetrosis | 3 |
Femur, Fibrous Osteodystrophy | 3 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 |
Meninges, Infiltration Cellular | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Nose | + + + + + + + + + I + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 0| 7| 8| 3| 3| 2| 3| 3| 3| 8| 3| 0| 3| 3| 9| 3| 3| 3|
| 1| 1| 1| 1| 1| 1| 4| 7| 8| 0| 1| 1| 0| 1| 1| 1| 9| 1| 7| 1| 1| 0| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Infiltration Cellular, Lymphocyte | 2 2 |
Metaplasia, Osseous | 2 |
Mineralization | 1 1 1 |
Renal Tubule, Casts | |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 1 3.0|
Eosinophilic Focus | | 6 2.3|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Karyomegaly | 2 | 1 2.0|
Mineralization | | 1 3.0|
Mixed Cell Focus | | 1 2.0|
Necrosis | | 2 2.0|
Vacuolization Cytoplasmic | | 1 3.0|
Bile Duct, Cyst | 2 | 1 2.0|
Hepatocyte, Hypertrophy, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Inflammation, Subacute | | 1 3.0|
Fat, Inflammation, Suppurative | 3 | 1 3.0|
Fat, Necrosis | 3 | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Edema | | 1 2.0|
Acinus, Atrophy | | 1 2.0|
Acinus, Depletion Secretory | | 3 2.3|
Duct, Cyst | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Hyperplasia | | 4 2.5|
Inflammation, Subacute | | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Cyst | | 4 1.8|
Erosion | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 2 1.5|
Hyperplasia | 1 | 1 1.0|
Hypertrophy | | 1 1.0|
Vacuolization Cytoplasmic | | 1 2.0|
X-Zone, Vacuolization Cytoplasmic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + + + + + | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + | 58 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | | 14 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | | 1 2.0|
Follicle, Cyst | | 3 3.0|
Follicular Cell, Hyperplasia | | 24 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Duct, Cyst | | 11 1.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Atrophy | | 1 3.0|
Cyst | 2 2 2 | 18 2.6|
Follicle, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Oviduct | | 1 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
Cyst | | 2 3.0|
Dilatation | 3 3 | 8 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | 2 2 2 3 2 2 2 2 2 | 57 2.3|
__________________________________________________________________________|____________|
Vagina | | 1 |
Inflammation, Granulomatous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Atrophy | | 1 2.0|
Hypercellularity | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 15 |
Iliac, Hyperplasia, Lymphoid | 2 | 3 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Infiltration Cellular, Mast Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Angiectasis | | 5 2.6|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | 2 | 15 2.6|
Hemorrhage | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 9 2.3|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 4 | 1 4.0|
Dermis, Inflammation, Subacute | | 2 1.5|
Subcutaneous Tissue, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Osteopetrosis | | 1 3.0|
Femur, Fibrous Osteodystrophy | | 3 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 4 3.0|
Meninges, Infiltration Cellular | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Infarct | | 1 1.0|
Infiltration Cellular, Lymphocyte | 2 | 4 2.0|
Metaplasia, Osseous | | 2 2.0|
Mineralization | 1 | 8 1.0|
Renal Tubule, Casts | 2 | 2 1.5|
Renal Tubule, Dilatation | | 1 1.0|
Renal Tubule, Regeneration | 2 1 1 | 15 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 1| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 6| 3| 9| 3|
| 0| 0| 0| 0| 9| 9| 0| 5| 0| 7| 0| 0| 0| 0| 0| 7| 6| 4| 6| 0| 0| 5| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + + + + A + + +|
Dilatation | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + A + A + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + A + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + A + + + A + + +|
Peyer's Patch, Necrosis | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + A + A + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | 2 3 |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Subacute | 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Subacute | 3 |
Fat, Hemorrhage | 3 |
Fat, Inflammation, Subacute | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +|
Basophilic Focus | |
Edema | 2 |
Acinus, Atrophy | 4 |
Acinus, Depletion Secretory | |
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Subacute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Cyst | 2 |
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 1| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 6| 3| 9| 3|
| 0| 0| 0| 0| 9| 9| 0| 5| 0| 7| 0| 0| 0| 0| 0| 7| 6| 4| 6| 0| 0| 5| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Coronary Artery, Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | 2 |
X-Zone, Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 |
Follicle, Degeneration | |
Follicular Cell, Hyperplasia | 1 1 1 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Duct, Cyst | 2 2 2 2 2 |
__________________________________________________________________________|
Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 3 4 |
Cyst | 2 2 2 2 2 3 3 |
Hemorrhage | 4 |
Inflammation, Subacute | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 2 |
Dilatation | 2 3 |
Hyperplasia, Cystic | 3 3 3 3 2 2 2 3 3 2 2 3 3 3 2 2 2 3 |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 4 |
Myeloid Cell, Depletion Cellular | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Iliac, Hyperplasia, Lymphoid | 3 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 1| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 6| 3| 9| 3|
| 0| 0| 0| 0| 9| 9| 0| 5| 0| 7| 0| 0| 0| 0| 0| 7| 6| 4| 6| 0| 0| 5| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Hyperplasia, Lymphoid | 3 3 |
Mediastinal, Edema | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Inflammation, Subacute | 3 |
Renal, Hyperplasia, Lymphoid | 4 2 |
Renal, Inflammation, Subacute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hyperplasia, Lymphoid | 3 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hematopoietic Cell Proliferation | 3 3 3 4 2 3 3 4 |
Hyperplasia, Lymphoid | 2 3 2 2 2 2 2 2|
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Duct, Cyst | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Subacute | 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | 3 |
Femur, Fibrous Osteodystrophy | 2 2 |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | |
Inflammation, Subacute | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Cyst | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 1| 3| 1| 3| 0| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 6| 3| 9| 3|
| 0| 0| 0| 0| 9| 9| 0| 5| 0| 7| 0| 0| 0| 0| 0| 7| 6| 4| 6| 0| 0| 5| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Subacute | 2 |
Metaplasia, Osseous | |
Mineralization | 1 2 |
Capsule, Fibrosis | |
Glomerulus, Amyloid Deposition | |
Renal Tubule, Casts | 2 |
Renal Tubule, Dilatation | 2 3 1 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 3 1 1 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 0| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 6| 6| 7| 7|
DAY ON TEST | 0| 3| 5| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 7| 3| 7| 6| 3| 3|
| 7| 1| 7| 1| 1| 0| 1| 0| 1| 1| 1| 1| 1| 1| 1| 6| 0| 2| 1| 1| 1| 8| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Peyer's Patch, Necrosis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 |
Clear Cell Focus | 2 |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Subacute | 4 |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Subacute | |
Fat, Hemorrhage | |
Fat, Inflammation, Subacute | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Edema | 2 |
Acinus, Atrophy | 2 4 |
Acinus, Depletion Secretory | 2 2 3 |
Duct, Cyst | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Erosion | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 3 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 0| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 6| 6| 7| 7|
DAY ON TEST | 0| 3| 5| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 7| 3| 7| 6| 3| 3|
| 7| 1| 7| 1| 1| 0| 1| 0| 1| 1| 1| 1| 1| 1| 1| 6| 0| 2| 1| 1| 1| 8| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Coronary Artery, Amyloid Deposition | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 |
Hyperplasia | |
X-Zone, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + I + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 2 2 3 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 |
Follicle, Degeneration | 2 |
Follicular Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Duct, Cyst | 2 2 2 2 2 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + M + + + + + + + + + + + + +|
Abscess | 4 4 |
Cyst | 3 2 2 3 2 3 3 |
Hemorrhage | 3 4 3 3 |
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 2 |
Dilatation | 3 2 |
Hyperplasia, Cystic | 2 2 3 2 2 2 3 3 2 2 3 3 2 3 1 3 2 2 2|
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
Myeloid Cell, Depletion Cellular | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 0| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 6| 6| 7| 7|
DAY ON TEST | 0| 3| 5| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 7| 3| 7| 6| 3| 3|
| 7| 1| 7| 1| 1| 0| 1| 0| 1| 1| 1| 1| 1| 1| 1| 6| 0| 2| 1| 1| 1| 8| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Edema | 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Inflammation, Subacute | 4 |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Inflammation, Subacute | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 3 3 |
Hyperplasia, Lymphoid | 3 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 2 4 |
Hyperplasia, Lymphoid | 2 3 3 3 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + M M + + + + + + + + + + + + + M +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | 2 2 2|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 3 |
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Cyst | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 0| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 6| 6| 7| 7|
DAY ON TEST | 0| 3| 5| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 7| 3| 7| 6| 3| 3|
| 7| 1| 7| 1| 1| 0| 1| 0| 1| 1| 1| 1| 1| 1| 1| 6| 0| 2| 1| 1| 1| 8| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | 1 |
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Subacute | |
Metaplasia, Osseous | 2 1 |
Mineralization | 1 1 1 |
Capsule, Fibrosis | 3 |
Glomerulus, Amyloid Deposition | 3 3 |
Renal Tubule, Casts | 2 2 1 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Pigmentation | 2 |
Renal Tubule, Regeneration | 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 58 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
Peyer's Patch, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | 2 | 2 2.0|
Clear Cell Focus | | 1 2.0|
Eosinophilic Focus | | 2 2.5|
Hematopoietic Cell Proliferation | | 2 2.0|
Inflammation, Subacute | 1 1 | 4 2.0|
Necrosis | | 2 2.0|
Vacuolization Cytoplasmic | | 1 1.0|
Bile Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 7 |
Inflammation, Subacute | | 1 3.0|
Fat, Hemorrhage | | 1 3.0|
Fat, Inflammation, Subacute | | 1 3.0|
Fat, Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Basophilic Focus | | 1 2.0|
Edema | | 2 2.0|
Acinus, Atrophy | | 3 3.3|
Acinus, Depletion Secretory | | 3 2.3|
Duct, Cyst | | 3 2.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Cytoplasmic Alteration | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Hyperplasia | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Cyst | | 1 2.0|
Erosion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Coronary Artery, Amyloid Deposition | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 2 2.0|
Hyperplasia | | 1 2.0|
X-Zone, Vacuolization Cytoplasmic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 | 11 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicle, Cyst | | 2 2.0|
Follicle, Degeneration | | 1 2.0|
Follicular Cell, Hyperplasia | | 8 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Inflammation, Subacute | | 1 2.0|
Duct, Cyst | | 11 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Abscess | | 6 3.8|
Cyst | 3 | 15 2.5|
Hemorrhage | | 5 3.4|
Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Atrophy | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | 2 2 | 6 2.3|
Hyperplasia, Cystic | 1 2 2 2 2 2 2 2 2 | 46 2.3|
Inflammation, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 4 3.3|
Myeloid Cell, Depletion Cellular | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 15 |
Iliac, Hyperplasia, Lymphoid | | 3 2.7|
Inguinal, Hyperplasia, Lymphoid | | 3 2.7|
Mediastinal, Edema | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Inflammation, Subacute | | 2 3.5|
Renal, Hyperplasia, Lymphoid | | 3 3.0|
Renal, Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Angiectasis | | 5 2.6|
Hyperplasia, Lymphoid | | 2 3.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Atrophy | | 2 4.0|
Hematopoietic Cell Proliferation | | 16 3.1|
Hyperplasia, Lymphoid | | 13 2.3|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
Atrophy | | 4 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Duct, Cyst | | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Dermis, Inflammation, Subacute | | 3 1.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Cranium, Fibrous Osteodystrophy | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Femur, Fibrous Osteodystrophy | | 5 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Hemorrhage | | 1 3.0|
Inflammation, Subacute | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Glands, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Glomerulosclerosis | | 1 1.0|
Infiltration Cellular, Lymphocyte | 2 | 2 2.5|
Inflammation, Subacute | | 1 2.0|
Metaplasia, Osseous | | 2 1.5|
Mineralization | | 5 1.2|
Capsule, Fibrosis | | 1 3.0|
Glomerulus, Amyloid Deposition | | 2 3.0|
Renal Tubule, Casts | | 4 1.8|
Renal Tubule, Dilatation | | 4 2.0|
Renal Tubule, Pigmentation | | 1 2.0|
Renal Tubule, Regeneration | 1 | 10 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 6| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 6| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | 2 1 3 |
Eosinophilic Focus | 2 3 3|
Hematopoietic Cell Proliferation | 1 1 |
Inflammation, Subacute | |
Mixed Cell Focus | 2 |
Necrosis | 3 3 |
Regeneration | 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Acinus, Atrophy | |
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Inflammation, Subacute | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Tooth | + |
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Hypertrophy | 2 1 1 1 3 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 6| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 6| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 2 1 2 1 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 3 |
Duct, Cyst | 2 2 3 2 2 2 2 2 2 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Dilatation | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Angiectasis | 3 |
Inguinal, Hyperplasia, Lymphoid | |
Pancreatic, Mineralization | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 2 2 2 2 2 1|
Atrophy | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 2 3 3 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + M M + +|
Atrophy | 3 |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 6| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 6| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Abscess | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Retrobulbar, Hemorrhage | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Glomerulosclerosis | |
Infarct | 2 2 1 |
Infiltration Cellular, Lymphocyte | 2 |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Cortex, Cyst | 2 3 2 2 1 |
Renal Tubule, Casts | 2 2 2 |
Renal Tubule, Regeneration | 1 1 2 1 1 2 1 1 2 1 1 1 1 1 1 1 3 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 7| 3| 9|
| 9| 8| 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 5| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Clear Cell Focus | 2 |
Eosinophilic Focus | 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Subacute | 2 |
Mixed Cell Focus | 3 3 3 4 2 |
Necrosis | 4 1 |
Regeneration | |
Vacuolization Cytoplasmic | 2 1 |
__________________________________________________________________________|
Mesentery | +|
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 2 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2 2|
Inflammation, Subacute | 3 |
Ulcer | 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Tooth | + |
Inflammation, Subacute | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hypertrophy | 1 2 1 2 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 7| 3| 9|
| 9| 8| 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 5| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + M M +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia | 2 1 2 1 2 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Dilatation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 2 3 2 3 3 3 2 2 |
Duct, Cyst | 2 2 2 2 3 2 2 2 3 2 3 3 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Angiectasis | |
Inguinal, Hyperplasia, Lymphoid | 2 |
Pancreatic, Mineralization | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 3 3 2 3 3 2|
Atrophy | 3 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2|
Hematopoietic Cell Proliferation | 4 2 3 2 3 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + M + +|
Atrophy | 3 2 3|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 7| 3| 9|
| 9| 8| 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 5| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 2|
Alveolar Epithelium, Hyperplasia | 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Retrobulbar, Hemorrhage | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Glomerulosclerosis | 2 2 |
Infarct | 2 1 2 2 |
Infiltration Cellular, Lymphocyte | |
Metaplasia, Osseous | 2 |
Mineralization | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1|
Cortex, Cyst | 2 2 1 2 2 2 |
Renal Tubule, Casts | 1 3 3 1 |
Renal Tubule, Regeneration | 1 1 2 1 1 1 2 1 1 1 1 2 1 2 1 1 1 3 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 1 2.0|
Clear Cell Focus | | 4 2.0|
Eosinophilic Focus | | 4 2.5|
Hematopoietic Cell Proliferation | | 2 1.0|
Inflammation, Subacute | | 1 2.0|
Mixed Cell Focus | 3 | 7 2.9|
Necrosis | | 4 2.8|
Regeneration | | 1 3.0|
Vacuolization Cytoplasmic | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 3.0|
Acinus, Atrophy | | 1 2.0|
Duct, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia | | 6 2.0|
Inflammation, Subacute | | 1 3.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Ulcer | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Inflammation, Subacute | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Hypertrophy | 2 | 15 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + | 59 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 56 |
Pars Distalis, Cyst | | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicle, Cyst | | 2 1.5|
Follicular Cell, Hyperplasia | | 15 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Inflammation, Subacute | | 11 2.6|
Duct, Cyst | 2 2 | 33 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 4 |
Inguinal, Angiectasis | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | 2 | 18 2.2|
Atrophy | | 1 3.0|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 12 2.7|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 55 |
Atrophy | | 4 2.8|
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Granulomatous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | | 1 2.0|
Retrobulbar, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Fibrosis | | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Glomerulosclerosis | | 2 2.0|
Infarct | | 7 1.7|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Metaplasia, Osseous | | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 | 50 1.1|
Cortex, Cyst | | 11 1.9|
Renal Tubule, Casts | | 7 2.0|
Renal Tubule, Regeneration | 2 1 1 1 2 2 1 | 50 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + A + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 4 3 |
Clear Cell Focus | 2 2 3|
Eosinophilic Focus | 3 2 2 3 2 2 3 2 4 2 2 3 |
Mixed Cell Focus | |
Necrosis | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Depletion Secretory | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
Duct, Cyst | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Subacute | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Artery, Inflammation, Subacute | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 |
Hyperplasia | 4 |
Hypertrophy | 1 2 2 2 2 2 1 3 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 2 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + I + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 1 1 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
Dilatation | 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Atrophy | |
Inflammation, Subacute | |
Duct, Cyst | 2 3 2 2 2 3 2 2 2 2 2 2 3 2 3 2 2 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Dilatation | 2 3 2 3 4 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
__________________________________________________________________________|
Lymph Node | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 3 3 2 2 2 2 3|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 3 2 2 4 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | |
Cyst | 2 1 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Dermis, Inflammation, Chronic | |
Dermis, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Glomerulosclerosis | 2 |
Infarct | 2 |
Metaplasia, Osseous | 2 |
Mineralization | 1 1 1 1 1 2 1 2 1 1 2 1 1 1 1 1 2 1 1|
Cortex, Cyst | 1 2 3 |
Renal Tubule, Casts | 2 2 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 3 1 1 2 1 1 2 2 1 2 1 1 2 1 1 2 1 1|
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Hemorrhage | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0|
DAY ON TEST | 3| 3| 8| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 3| 7| 3| 0| 5| 0|
| 0| 0| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 5| 0| 0| 7| 0| 5| 0| 0| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + A + A + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + A + A + A + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + A + A + A + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + A + A + A|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + A + A + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | 1 2 1 |
Eosinophilic Focus | 3 3 1 2 2 |
Mixed Cell Focus | 3 3 3 3 2 |
Necrosis | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +|
Acinus, Atrophy | |
Acinus, Depletion Secretory | 3 |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Duct, Cyst | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + A + +|
Hyperplasia | 1 3 3 2 |
Inflammation, Subacute | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + A + +|
Cyst | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Artery, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | |
Hypertrophy | 3 2 3 2 2 1 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0|
DAY ON TEST | 3| 3| 8| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 3| 7| 3| 0| 5| 0|
| 0| 0| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 5| 0| 0| 7| 0| 5| 0| 0| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + I|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 1 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Dilatation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Atrophy | |
Inflammation, Subacute | 2 2 |
Duct, Cyst | 3 2 3 3 2 2 3 2 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 3 2 2 3 2 3 3 3 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3|
Hematopoietic Cell Proliferation | 3 3 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + M + + + + + + + + +|
Atrophy | 3|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0|
DAY ON TEST | 3| 3| 8| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 3| 7| 3| 0| 5| 0|
| 0| 0| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 5| 0| 0| 7| 0| 5| 0| 0| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Dermis, Inflammation, Chronic | 3 |
Dermis, Inflammation, Subacute | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 |
Alveolar Epithelium, Hyperplasia | 2 2 1 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 |
Glomerulosclerosis | 1 1 2 3 |
Infarct | 2 1 2 |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 |
Cortex, Cyst | 2 2 2 |
Renal Tubule, Casts | 1 2 1 3 2 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 1 1 1 1 2 1 2 1 2 3 1 1 1 1 1 2 1 2 |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Hemorrhage | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + | 53 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | 2 | 4 3.0|
Clear Cell Focus | | 6 1.8|
Eosinophilic Focus | | 17 2.4|
Mixed Cell Focus | | 5 2.8|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A + + | 58 |
Acinus, Atrophy | 1 | 1 1.0|
Acinus, Depletion Secretory | | 1 3.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + A + + | 59 |
Acinus, Atrophy | | 1 2.0|
Duct, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + A + + | 57 |
Hyperplasia | | 4 2.3|
Inflammation, Subacute | | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + | 57 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + A + + | 59 |
Cardiomyopathy | | 1 2.0|
Artery, Inflammation, Subacute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + A + + | 59 |
Accessory Adrenal Cortical Nodule | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 4.0|
Hypertrophy | 1 | 18 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + A + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A + + | 59 |
Hyperplasia | | 3 3.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + M + + | 55 |
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + A + + | 59 |
Follicle, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | | 12 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + A + + | 59 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + A + + | 59 |
Abscess | | 2 4.0|
Atrophy | 2 | 1 2.0|
Inflammation, Subacute | | 2 2.0|
Duct, Cyst | 2 | 37 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + A + + | 59 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + A + + | 59 |
Atrophy | | 1 3.0|
Dilatation | | 6 2.7|
__________________________________________________________________________|____________|
Testes | + + + + + + + A + + | 59 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + A + + | 59 |
Hypercellularity | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Renal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + A + + | 57 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + A + + | 59 |
Angiectasis | 2 | 21 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + M + + | 59 |
Atrophy | | 2 3.0|
Hematopoietic Cell Proliferation | 3 | 9 2.8|
Hyperplasia, Lymphoid | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M | 56 |
Atrophy | | 1 3.0|
Cyst | | 4 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skin | + + + + + + + A + + | 59 |
Ulcer | | 1 3.0|
Dermis, Inflammation, Chronic | | 1 3.0|
Dermis, Inflammation, Subacute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Cranium, Hyperostosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 8 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + A + + | 59 |
Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + A + + | 59 |
Fibrosis | | 2 1.5|
Glomerulosclerosis | | 5 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Infarct | | 4 1.8|
Metaplasia, Osseous | | 1 2.0|
Mineralization | 1 1 1 1 | 37 1.1|
Cortex, Cyst | | 6 2.0|
Renal Tubule, Casts | 2 | 8 1.9|
Renal Tubule, Pigmentation | 2 | 1 2.0|
Renal Tubule, Regeneration | 1 1 1 1 2 | 43 1.4|
__________________________________________________________________________|____________|
Urethra | | 1 |
Bulbourethral Gland, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 0| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 2|
| 9| 3| 1| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 |
Cytologic Alterations | |
Eosinophilic Focus | 2 2 3 2 |
Inflammation, Subacute | 1 |
Mixed Cell Focus | 2 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 2 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Granulomatous | 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Acinus, Atrophy | 3 |
Acinus, Depletion Secretory | |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Mineralization | |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Hypertrophy | 1 1 3 2 2 2 2 2 |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 0| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 2|
| 9| 3| 1| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | 2 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Atrophy | |
Cyst | 2 |
Inflammation, Chronic | 3 |
Inflammation, Subacute | 3 2 2 2 2 |
Duct, Cyst | 2 3 2 2 3 2 2 3 2 2 3 2 2 2 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Dilatation | |
Inflammation, Chronic | |
Inflammation, Subacute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | |
Axillary, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 3 2 3 2 2 2 3 2 2 3|
Hematopoietic Cell Proliferation | 2|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 0| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 2|
| 9| 3| 1| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 2 2 2 |
Hematopoietic Cell Proliferation | 3 3 3 2 2|
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + M +|
Atrophy | 3 |
Cyst | |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Subacute | |
Pinna, Inflammation, Subacute | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 4 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 3 2 2 1 |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Ectasia | 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Retrobulbar, Hemorrhage | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 0| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 2|
| 9| 3| 1| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Fibrosis | 1 |
Glomerulosclerosis | 2 2 2 2|
Hydronephrosis | |
Infarct | 1 1 1 |
Inflammation, Subacute | 2 |
Metaplasia, Osseous | 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 |
Cortex, Cyst | 2 1|
Renal Tubule, Casts | 3 3 2 2|
Renal Tubule, Regeneration | 1 1 2 1 2 1 1 2 2 1 1 1 1 2 1 1 1 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 2| 9| 8| 9| 2| 5|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| 8| 9| 9| 5| 1| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 2 1 2 |
Cytologic Alterations | 2 |
Eosinophilic Focus | 2 |
Inflammation, Subacute | 1|
Mixed Cell Focus | 2 2 2 |
Necrosis | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Granulomatous | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Acinus, Atrophy | |
Acinus, Depletion Secretory | 3 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Mineralization | |
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 3 |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hypertrophy | 3 2 1 2 3 2 2 2 |
Spindle Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 2| 9| 8| 9| 2| 5|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| 8| 9| 9| 5| 1| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 3 3 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Atrophy | 2 |
Cyst | |
Inflammation, Chronic | |
Inflammation, Subacute | 2 2 3 3 3 |
Duct, Cyst | 2 2 2 2 2 3 2 2 2 2 2 3 3 2 X 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Dilatation | 3 |
Inflammation, Chronic | 3 |
Inflammation, Subacute | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 4 |
__________________________________________________________________________|
Lymph Node | + + + |
Axillary, Hyperplasia, Lymphoid | 3 |
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 2 2 3 4 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 2| 9| 8| 9| 2| 5|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| 8| 9| 9| 5| 1| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | |
Hematopoietic Cell Proliferation | 2 2 2 3 4 2|
Necrosis | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Subacute | 1 |
Pinna, Inflammation, Subacute | |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 3 |
Bronchiole, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + M + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Ectasia | |
Nasolacrimal Duct, Inflammation, | |
Subacute | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Retrobulbar, Hemorrhage | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 2| 9| 8| 9| 2| 5|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| 8| 9| 9| 5| 1| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Fibrosis | 2 3|
Glomerulosclerosis | 3 1 |
Hydronephrosis | 2|
Infarct | 2 1 |
Inflammation, Subacute | 4|
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 |
Cortex, Cyst | 2 1 2 |
Renal Tubule, Casts | 2 3 3 |
Renal Tubule, Regeneration | 1 1 1 1 1 2 1 2 2 1 2 1 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Clear Cell Focus | | 5 1.8|
Cytologic Alterations | | 1 2.0|
Eosinophilic Focus | | 5 2.2|
Inflammation, Subacute | | 2 1.0|
Mixed Cell Focus | | 5 2.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 2 1 | 6 1.5|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Inflammation, Granulomatous | | 1 3.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Acinus, Atrophy | 2 | 2 2.5|
Acinus, Depletion Secretory | | 1 3.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst | | 2 2.0|
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Dysplasia | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Fibrosis | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Hypertrophy | 3 | 17 2.1|
Spindle Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + | 58 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia | | 8 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Cyst, Multiple | | 1 2.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Abscess | | 1 3.0|
Atrophy | | 1 2.0|
Cyst | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Subacute | | 10 2.4|
Duct, Cyst | 2 2 2 | 39 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Atrophy | | 2 3.0|
Dilatation | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Subacute | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Axillary, Hyperplasia, Lymphoid | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | | 20 2.5|
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Atrophy | | 3 2.0|
Hematopoietic Cell Proliferation | | 11 2.5|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
Atrophy | | 2 2.5|
Cyst | | 1 1.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Dermis, Inflammation, Subacute | | 1 1.0|
Pinna, Inflammation, Subacute | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | | 1 4.0|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 2 | 8 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Bronchiole, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Nasolacrimal Duct, Ectasia | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Retrobulbar, Hemorrhage | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Fibrosis | | 3 2.0|
Glomerulosclerosis | | 6 2.0|
Hydronephrosis | | 1 2.0|
Infarct | | 5 1.2|
Inflammation, Subacute | | 2 3.0|
Metaplasia, Osseous | | 1 1.0|
Mineralization | 1 1 1 1 1 1 | 28 1.0|
Cortex, Cyst | | 5 1.6|
Renal Tubule, Casts | | 7 2.6|
Renal Tubule, Regeneration | 1 1 1 1 2 1 1 1 | 42 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2|
| 9| 9| 9| 9| 9| 7| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 4 |
Clear Cell Focus | 1 |
Eosinophilic Focus | 2 |
Karyomegaly | |
Mixed Cell Focus | |
Vacuolization Cytoplasmic | 1 |
Hepatocyte, Hypertrophy, Focal | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Tooth | + |
Dysplasia | |
Inflammation, Chronic | 3 |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Hypertrophy | 2 2 2 2 4 2 3 1 2 |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + M + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2|
| 9| 9| 9| 9| 9| 7| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 3 |
Follicle, Degeneration | |
Follicular Cell, Hyperplasia | 1 1 1 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Cyst | |
Infiltration Cellular, Subacute | 2 |
Inflammation, Subacute | 3 2 |
Duct, Cyst | 2 2 2 3 2 3 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hypercellularity | 3 3|
__________________________________________________________________________|
Lymph Node | + + |
Axillary, Hyperplasia, Lymphoid | 3 |
Bronchial, Hyperplasia, Lymphoid | 2 2 |
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
Infiltration Cellular, Mast Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 3 3 2 3 3 3 3 3 2 |
Hematopoietic Cell Proliferation | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 |
Hematopoietic Cell Proliferation | 2 3 3|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2|
| 9| 9| 9| 9| 9| 7| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Dermis, Inflammation, Subacute | 2 |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Infiltration Cellular, Histiocyte | 1 2 3 |
Inflammation, Subacute | 2 3 2 |
Alveolar Epithelium, Hyperplasia | 3 1 2 2 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation, Subacute | |
Lumen, Hemorrhage | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Retrobulbar, Hemorrhage | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1|
Glomerulosclerosis | 2 |
Hemorrhage | 3 |
Infarct | 1 1 |
Mineralization | 1 1 1 1 1 2 1 1 1 1 1 1 |
Cortex, Cyst | 1 2 |
Renal Tubule, Casts | 2 3|
Renal Tubule, Regeneration | 1 2 2 1 1 2 2 1 1 2 1 1 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5|
| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + A + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 3 2|
Clear Cell Focus | 3 |
Eosinophilic Focus | 2 2 3 |
Karyomegaly | 2|
Mixed Cell Focus | 2 2 |
Vacuolization Cytoplasmic | 1 1 |
Hepatocyte, Hypertrophy, Focal | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
Inflammation, Chronic | |
Inflammation, Subacute | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | 2 2 1 1 1 1 |
Spindle Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5|
| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 3 |
Follicle, Degeneration | |
Follicular Cell, Hyperplasia | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst | 2 |
Infiltration Cellular, Subacute | |
Inflammation, Subacute | 3 3 |
Duct, Cyst | 2 2 2 2 3 2 2 3 3 2 3 2 2 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hypercellularity | 3 |
__________________________________________________________________________|
Lymph Node | + + |
Axillary, Hyperplasia, Lymphoid | |
Bronchial, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Mast Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 4 1 3 3 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 2 |
Hematopoietic Cell Proliferation | 3 3 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5|
| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Dermis, Inflammation, Subacute | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | |
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation, Subacute | 2 |
Lumen, Hemorrhage | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Retrobulbar, Hemorrhage | 2|
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Glomerulosclerosis | 3 |
Hemorrhage | |
Infarct | 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 |
Cortex, Cyst | 2 |
Renal Tubule, Casts | 2 |
Renal Tubule, Regeneration | 1 1 2 1 3 2 2 2 1 1 2 1 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A + | 58 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + A + | 58 |
Basophilic Focus | | 5 2.8|
Clear Cell Focus | | 2 2.0|
Eosinophilic Focus | | 4 2.3|
Karyomegaly | | 1 2.0|
Mixed Cell Focus | 3 | 3 2.3|
Vacuolization Cytoplasmic | 2 | 4 1.3|
Hepatocyte, Hypertrophy, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + A + | 57 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + | 57 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Dysplasia | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Subacute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Fibrosis | | 1 1.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Hyperplasia | | 1 3.0|
Hypertrophy | 1 2 | 17 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Spindle Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + | 56 |
Pars Distalis, Cyst | | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Follicle, Cyst | | 3 2.7|
Follicle, Degeneration | 1 | 1 1.0|
Follicular Cell, Hyperplasia | | 9 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Abscess | | 2 3.5|
Cyst | | 1 2.0|
Infiltration Cellular, Subacute | | 1 2.0|
Inflammation, Subacute | 2 | 5 2.6|
Duct, Cyst | 2 2 2 | 30 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Polyarteritis | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hypercellularity | | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 4 |
Axillary, Hyperplasia, Lymphoid | | 1 3.0|
Bronchial, Hyperplasia, Lymphoid | | 2 2.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infiltration Cellular, Mast Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + A + | 57 |
Angiectasis | | 17 2.7|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + A + | 59 |
Atrophy | | 5 2.8|
Hematopoietic Cell Proliferation | | 6 2.7|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + | 57 |
Atrophy | | 1 2.0|
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + | 58 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Ulcer | | 1 2.0|
Dermis, Inflammation, Subacute | | 1 2.0|
Subcutaneous Tissue, Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Femur, Fibrous Osteodystrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Infiltration Cellular, Histiocyte | | 3 2.0|
Inflammation, Subacute | | 3 2.3|
Alveolar Epithelium, Hyperplasia | | 8 2.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Glands, Inflammation, Subacute | | 1 2.0|
Lumen, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05155-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 15:16:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Retrobulbar, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + A + | 58 |
Fibrosis | | 2 1.5|
Glomerulosclerosis | | 2 2.5|
Hemorrhage | | 1 3.0|
Infarct | | 3 1.0|
Mineralization | 1 1 1 1 | 35 1.1|
Cortex, Cyst | | 3 1.7|
Renal Tubule, Casts | | 3 2.3|
Renal Tubule, Regeneration | 1 1 1 | 35 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
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---------- END OF REPORT ----------
------------------------------------------------------------