TDMS Study 05155-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 05/08/95
EXP: 05155 P-NITROBENZOIC ACID TIME: 19:27:50
TEST: 04 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 61778B
CONT: N01-ES-85217 CAS: 62-23-7
PATHOLOGIST: DR R. THOMPSON HAILEY, JAMESR.
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 05/08/95
EXP: 05155 P-NITROBENZOIC ACID TIME: 19:27:50
TEST: 04 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 61778B
CONT: N01-ES-85217 CAS: 62-23-7
PATHOLOGIST: DR R. THOMPSON HAILEY, JAMESR.
P-NITROBENZOIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 419 532 537 597 660 666 675 720 720 728 |
| 728 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.125% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 11 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 442 537 575 601 665 675 681 695 700 701 |
| 720 725 728 |
| CENSORED DEATHS |
| 7 456 456 456 456 456 456 456 456 456 |
| 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 451 496 522 588 638 675 681 681 693 695 |
| 703 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
P-NITROBENZOIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.5% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 4 CENSORED DEATHS 12 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 188 378 582 667 |
| CENSORED DEATHS |
| 7 7 456 456 456 456 456 456 456 456 |
| 456 456 |
| |
==================================================================================
P-NITROBENZOIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 100.0 100.0 98.3 98.3 94.3 92.3 90.3 78.3 |
| | |
| | |
|0.125% | 100.0 100.0 100.0 100.0 100.0 98.3 96.3 92.2 90.1 73.7 |
| | |
| | |
|0.25% | 100.0 100.0 100.0 100.0 100.0 98.3 94.3 92.3 90.3 78.3 |
| | |
| | |
|0.5% | 100.0 100.0 98.3 98.3 96.6 96.6 96.6 94.5 94.5 92.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 0.125% 0.25% 0.5% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.3% 73.7% 78.3% 92.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.077N P=0.764 P=1.000 P=0.125N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 634.7 649.6 620.3 453.8 |
|NATURAL DEATHS (C) | (30.6) (24.0) (27.5) ( 107) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 666.2 654.3 663.6 641.1 |
|(STANDARD ERROR) | (14.2) (17.7) (14.1) (22.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P-NITROBENZOIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 12 CENSORED DEATHS 10 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 364 423 533 533 589 616 639 689 693 723 |
| 728 728 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.125% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 11 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 400 526 550 594 598 620 657 678 681 685 |
| 685 701 701 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| 526 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 11 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 480 490 569 589 624 629 638 651 678 680 |
| 689 707 707 715 720 720 |
| CENSORED DEATHS |
| 7 457 457 457 457 457 457 457 457 457 |
| 457 |
| |
==================================================================================
P-NITROBENZOIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.5% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 12 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 457 471 490 519 565 570 584 616 630 636 |
| 637 646 665 678 700 709 712 715 |
| CENSORED DEATHS |
| 7 7 457 457 457 457 457 457 457 457 |
| 457 457 |
| |
==================================================================================
P-NITROBENZOIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 100.0 98.3 96.7 96.7 92.6 90.6 86.6 76.5 |
| | |
| | |
|0.125% | 100.0 100.0 100.0 100.0 98.3 98.3 96.3 90.2 86.1 73.8 |
| | |
| | |
|0.25% | 100.0 100.0 100.0 100.0 100.0 98.0 95.9 91.8 83.7 67.3 |
| | |
| | |
|0.5% | 100.0 100.0 100.0 100.0 100.0 96.2 92.0 85.7 73.2 62.7 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 0.125% 0.25% 0.5% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.5% 73.8% 67.3% 62.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.118 P=0.925 P=0.465 P=0.194 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 604.8 621.2 642.9 611.1 |
|NATURAL DEATHS (C) | (35.0) (24.5) (19.3) (19.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 659.5 657.5 649.2 624.7 |
|(STANDARD ERROR) | (15.0) (14.3) (17.5) (20.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P-NITROBENZOIC ACID
KAPLAN-MEIER SURVIVAL CURVES
0.0% = 1
0.125% = 2
0.25% = 3
0.5% = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 1 2 3
| 4 4 1 2 3 3 12
|
| 4 3 311 24
P 95 + 4 4
E | 3 1 23 1
R | 3 1 3 14 4
C |
E 90 + 3 112
N | 113
T | 22
| 12 2 1
S 85 +
U | 33
R | 322 11
V |
I 80 + 32 2
V | 3 1 1
A | 22
L |
75 +
| 2 2
|
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.
P-NITROBENZOIC ACID
KAPLAN-MEIER SURVIVAL CURVES
0.0% = 1
0.125% = 2
0.25% = 3
0.5% = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 4 3
| 1 2 1 4 4 2
| 33
| 1 4 3 21 2 3
95 +
| 4 4 2 3 2
| 4 1 4 12
| 1 1 3
P 90 + 44 2 2
E | 12 1 2
R | 4 4 3 3
C | 4 4 132 2 1
E 85 +
N | 4 4 3 22
T | 1 1
| 44 33
S 80 + 33
U |
R | 4 4 23 2
V | 1 1
I 75 + 4 4
V | 4 4 2 3 2
A |
L | 4 4
70 +
| 4 4
| 3 3
|
65 + 44
|
| 4 4
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.