TDMS Study 05155-03 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
P-NITROBENZOIC ACID
NTP Experiment-Test: 05155-03 Report: PEIRPT03
Study Type: CHRONIC Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
Facility: Southern Research Institute
Chemical CAS #: 62-23-7
Lock Date: 02/15/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 21 23 27 26
Natural Death 2 4 2 3
Survivors
Terminal Sacrifice 27 23 21 21
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (60) (58) (60) (60)
Parasite Metazoan 1 (2%) 1 (2%)
Intestine Large, Rectum (60) (58) (60) (58)
Parasite Metazoan 7 (12%) 2 (3%) 4 (7%)
Intestine Large, Cecum (60) (57) (60) (59)
Parasite Metazoan 1 (2%)
Liver (60) (60) (60) (60)
Angiectasis 1 (2%) 2 (3%) 2 (3%)
Basophilic Focus 40 (67%) 43 (72%) 50 (83%) 55 (92%)
Clear Cell Focus 4 (7%) 7 (12%) 7 (12%) 12 (20%)
Eosinophilic Focus 4 (7%) 4 (7%) 1 (2%)
Fatty Change 14 (23%) 14 (23%) 7 (12%) 7 (12%)
Fibrosis, Focal 1 (2%) 2 (3%)
Focal Cellular Change 1 (2%) 1 (2%) 2 (3%)
Hematopoietic Cell Proliferation 2 (3%) 2 (3%) 1 (2%)
Hepatodiaphragmatic Nodule 8 (13%) 6 (10%) 12 (20%) 16 (27%)
Hepatodiaphragmatic Nodule, Multiple 2 (3%) 2 (3%) 3 (5%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Multifocal 9 (15%) 10 (17%) 3 (5%) 2 (3%)
Infiltration Cellular, Mixed Cell 1 (2%) 4 (7%) 3 (5%) 1 (2%)
Inflammation, Focal 33 (55%) 33 (55%) 41 (68%) 45 (75%)
Mixed Cell Focus 5 (8%) 8 (13%) 4 (7%) 7 (12%)
Necrosis, Focal 2 (3%) 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Dilatation 1 (2%)
Bile Duct, Hyperplasia 27 (45%) 25 (42%) 24 (40%) 33 (55%)
Centrilobular, Atrophy 14 (23%) 11 (18%) 4 (7%) 2 (3%)
Centrilobular, Congestion 1 (2%)
Centrilobular, Hemorrhage 1 (2%)
Centrilobular, Necrosis 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (11) (9) (10) (6)
Accessory Spleen 1 (11%) 1 (17%)
Cyst 1 (10%)
Inflammation, Chronic 1 (11%) 1 (10%) 1 (17%)
Fat, Necrosis 7 (64%) 4 (44%) 7 (70%) 4 (67%)
Pancreas (60) (60) (59) (59)
Accessory Spleen 1 (2%) 1 (2%)
Atrophy, Diffuse 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Atrophy, Focal 21 (35%) 18 (30%) 21 (36%) 13 (22%)
Cyst 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Acinar Cell, Depletion Secretory 1 (2%)
Duct, Dilatation 1 (2%)
Stomach, Forestomach (60) (60) (59) (59)
Edema 1 (2%)
Hemorrhage, Focal 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 2 (3%) 1 (2%)
Ulcer 1 (2%) 2 (3%)
Mucosa, Hyperplasia 2 (3%) 1 (2%) 1 (2%) 2 (3%)
Stomach, Glandular (60) (60) (59) (59)
Bacterium 1 (2%)
Erosion 2 (3%) 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
Tongue (1) (1)
Hypertrophy, Squamous 1 (100%)
Tooth (1)
Gingiva, Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (60) (60) (60) (60)
Mesenteric Artery, Inflammation, Chronic 1 (2%) 2 (3%)
Mesenteric Artery, Thrombosis 1 (2%)
Heart (60) (60) (60) (60)
Bacterium 1 (2%)
Embolus 1 (2%)
Inflammation, Chronic, Focal 2 (3%) 1 (2%)
Artery, Inflammation, Chronic 2 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (60) (60) (60)
Accessory Adrenal Cortical Nodule 2 (3%) 1 (2%) 3 (5%)
Angiectasis 1 (2%) 2 (3%)
Congestion 4 (7%) 1 (2%) 2 (3%)
Degeneration, Cystic 2 (3%)
Depletion Cellular 1 (2%)
Focal Cellular Change 13 (22%) 9 (15%) 10 (17%) 13 (22%)
Hyperplasia, Focal 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Capsule, Extra Adrenal Tissue, Fibrosis 1 (2%)
Adrenal Medulla (59) (60) (60) (60)
Hyperplasia 2 (3%) 1 (2%) 2 (3%) 2 (3%)
Pituitary Gland (60) (60) (59) (59)
Angiectasis 19 (32%) 13 (22%) 12 (20%) 11 (19%)
Cyst 4 (7%) 6 (10%) 2 (3%) 4 (7%)
Granuloma 1 (2%)
Hemorrhage 1 (2%)
Pars Distalis, Cyst 1 (2%) 1 (2%)
Pars Distalis, Focal Cellular Change 6 (10%) 4 (7%) 2 (3%) 3 (5%)
Pars Distalis, Hyperplasia, Focal 16 (27%) 11 (18%) 14 (24%) 9 (15%)
Rathke's Cleft, Hyperplasia, Cystic 1 (2%)
Thyroid Gland (60) (59) (60) (60)
Degeneration, Cystic 1 (2%)
Inflammation, Focal 1 (2%)
Ultimobranchial Cyst 2 (3%) 3 (5%)
C-Cell, Hyperplasia 10 (17%) 8 (14%) 11 (18%) 14 (23%)
Follicle, Dilatation 1 (2%)
Follicular Cell, Hyperplasia 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (60) (59) (59) (60)
Atrophy 1 (2%)
Cyst 1 (2%) 1 (2%) 1 (2%) 2 (3%)
Degeneration, Cystic 42 (70%) 43 (73%) 47 (80%) 39 (65%)
Hyperplasia 10 (17%) 6 (10%) 6 (10%) 7 (12%)
Inflammation, Chronic 1 (2%) 1 (2%)
Duct, Hyperplasia, Squamous 1 (2%)
Ovary (60) (60) (60) (59)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Angiectasis 1 (2%) 1 (2%)
Atrophy 1 (2%)
Cyst 5 (8%) 10 (17%) 10 (17%) 9 (15%)
Hemorrhage 1 (2%)
Bilateral, Cyst 1 (2%)
Corpus Luteum, Hyperplasia, Lymphoid 2 (3%) 1 (2%)
Corpus Luteum, Thecal Cell, Hyperplasia 2 (3%) 1 (2%)
Uterus (60) (60) (60) (59)
Hydrometra 1 (2%) 6 (10%) 5 (8%) 3 (5%)
Endometrium, Cyst 1 (2%) 1 (2%) 1 (2%)
Endometrium, Hyperplasia, Cystic 3 (5%) 10 (17%) 4 (7%) 6 (10%)
Endometrium, Infarct 2 (3%)
Vagina (3) (2) (3)
Cyst 2 (67%) 2 (100%) 1 (33%)
Cyst, Multiple 1 (33%)
Inflammation, Chronic 1 (33%)
Mucosa, Hyperplasia 1 (33%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Hypercellularity 2 (3%) 4 (7%) 2 (3%) 3 (5%)
Hyperplasia, Focal, Histiocytic 3 (5%) 4 (7%) 4 (7%) 4 (7%)
Metaplasia, Osseous 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node (14) (14) (11) (10)
Deep Cervical, Angiectasis 1 (9%)
Inguinal, Depletion Lymphoid 1 (7%)
Inguinal, Hyperplasia 2 (20%)
Mediastinal, Angiectasis 1 (9%)
Mediastinal, Congestion 1 (7%) 3 (21%) 7 (64%) 1 (10%)
Mediastinal, Depletion Lymphoid 1 (7%)
Mediastinal, Hyperplasia 3 (30%)
Mediastinal, Hyperplasia, Lymphoid 1 (7%)
Mediastinal, Hyperplasia, Macrophage 1 (9%)
Mediastinal, Pigmentation 2 (18%) 2 (20%)
Pancreatic, Congestion 2 (14%)
Pancreatic, Depletion Lymphoid 1 (7%)
Pancreatic, Edema 1 (10%)
Pancreatic, Hyperplasia, Lymphoid 1 (10%)
Pancreatic, Inflammation, Chronic 1 (10%)
Pancreatic, Pigmentation 1 (10%)
Renal, Hyperplasia, Macrophage 1 (10%)
Renal, Pigmentation 1 (10%)
Lymph Node, Mandibular (60) (60) (60) (60)
Congestion 1 (2%) 1 (2%) 2 (3%) 4 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Depletion Lymphoid 1 (2%)
Hyperplasia 2 (3%) 2 (3%) 1 (2%)
Hyperplasia, Lymphoid 2 (3%)
Pigmentation 2 (3%)
Lymph Node, Mesenteric (59) (60) (60) (59)
Congestion 1 (2%)
Depletion Lymphoid 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Spleen (60) (60) (60) (59)
Cyst 1 (2%)
Fibrosis 1 (2%) 6 (10%) 1 (2%)
Hematopoietic Cell Proliferation 2 (3%) 14 (23%) 9 (15%) 8 (14%)
Necrosis, Focal 2 (3%) 1 (2%)
Pigmentation 60 (100%) 60 (100%) 60 (100%) 59 (100%)
Thymus (59) (58) (60) (60)
Congestion 1 (2%)
Cyst 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60) (60) (60)
Dilatation 44 (73%) 40 (67%) 42 (70%) 37 (62%)
Hyperplasia 9 (15%) 15 (25%) 13 (22%) 16 (27%)
Skin (60) (60) (60) (60)
Cyst Epithelial Inclusion 1 (2%)
Hemorrhage, Focal 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Ulcer 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic,
Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Fracture Healed 1 (2%)
Hyperostosis 18 (30%) 11 (18%) 9 (15%) 9 (15%)
Inflammation, Chronic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 8 (13%) 16 (27%) 11 (18%) 14 (23%)
Demyelination, Focal 1 (2%)
Hemorrhage 4 (7%) 1 (2%) 1 (2%) 1 (2%)
Spinal Cord (1) (2) (2)
Hemorrhage, Focal 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Bacterium 1 (2%)
Congestion 1 (2%) 2 (3%)
Fibrosis, Focal 1 (2%) 1 (2%)
Hemorrhage, Focal 2 (3%)
Hyperplasia, Focal, Macrophage 1 (2%) 2 (3%)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%) 1 (2%)
Metaplasia, Focal, Osseous 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (5%) 3 (5%) 4 (7%) 4 (7%)
Mediastinum, Infiltration Cellular,
Lymphocyte 1 (2%)
Nose (60) (60) (60) (59)
Fungus 1 (2%)
Inflammation, Suppurative 2 (3%) 4 (7%) 5 (8%) 2 (3%)
Nasolacrimal Duct, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (2) (2) (1)
Atrophy 1 (50%)
Cataract 3 (75%) 1 (50%) 2 (100%) 1 (100%)
Fibrosis 1 (25%)
Hemorrhage 1 (25%) 1 (50%) 1 (50%)
Inflammation, Chronic 1 (25%) 1 (50%) 1 (50%)
Necrosis, Focal 1 (50%)
Retina, Degeneration 3 (75%) 1 (50%) 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Atrophy, Focal 1 (2%)
Bacterium 1 (2%)
Congestion 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Cyst 1 (2%) 1 (2%)
Fibrosis, Focal 1 (2%)
Nephropathy 60 (100%) 59 (98%) 58 (97%) 58 (97%)
Cortex, Renal Tubule, Autolysis 1 (2%)
Glomerulus, Autolysis 1 (2%)
Interstitium, Infarct 1 (2%)
Papilla, Epithelium, Hyperplasia, Focal 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Hyperplasia, Oncocytic 1 (2%) 5 (8%)
Renal Tubule, Pigmentation 60 (100%) 60 (100%) 60 (100%) 60 (100%)
Urinary Bladder (60) (60) (60) (60)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 32 34 34 25
Natural Death 6 3 3 4
Survivors
Terminal Sacrifice 12 13 13 21
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (59) (60) (59) (59)
Parasite Metazoan 2 (3%) 1 (2%) 2 (3%)
Intestine Large, Rectum (59) (60) (59) (60)
Parasite Metazoan 3 (5%) 4 (7%) 5 (8%) 1 (2%)
Intestine Large, Cecum (59) (60) (59) (60)
Inflammation, Chronic 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Small, Duodenum (58) (58) (59) (60)
Mucosa, Hyperplasia 1 (2%)
Intestine Small, Jejunum (59) (59) (59) (60)
Necrosis 1 (2%)
Ulcer 1 (2%)
Intestine Small, Ileum (58) (59) (59) (60)
Diverticulum 1 (2%)
Fibrosis 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Ulcer 1 (2%)
Liver (59) (60) (60) (60)
Angiectasis 4 (7%) 6 (10%) 6 (10%) 1 (2%)
Atrophy, Focal 1 (2%)
Autolysis 1 (2%)
Basophilic Focus 18 (31%) 19 (32%) 30 (50%) 35 (58%)
Clear Cell Focus 8 (14%) 8 (13%) 9 (15%) 12 (20%)
Congestion, Focal 3 (5%) 1 (2%)
Degeneration, Cystic 7 (12%) 11 (18%) 11 (18%) 12 (20%)
Developmental Malformation 1 (2%)
Eosinophilic Focus 5 (8%) 5 (8%) 7 (12%) 5 (8%)
Fatty Change 25 (42%) 21 (35%) 21 (35%) 16 (27%)
Fibrosis, Focal 1 (2%)
Focal Cellular Change 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 2 (3%)
Hemorrhage, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatodiaphragmatic Nodule 7 (12%) 2 (3%) 12 (20%) 9 (15%)
Hepatodiaphragmatic Nodule, Multiple 2 (3%) 1 (2%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Multifocal 13 (22%) 12 (20%) 13 (22%) 4 (7%)
Infiltration Cellular, Mixed Cell 7 (12%) 5 (8%) 4 (7%) 3 (5%)
Inflammation, Focal 18 (31%) 16 (27%) 22 (37%) 32 (53%)
Mixed Cell Focus 2 (3%) 3 (5%) 1 (2%) 2 (3%)
Necrosis, Focal 6 (10%) 3 (5%) 1 (2%)
Pigmentation 1 (2%)
Thrombosis 2 (3%)
Bile Duct, Hyperplasia 58 (98%) 58 (97%) 59 (98%) 58 (97%)
Centrilobular, Atrophy 22 (37%) 27 (45%) 23 (38%) 5 (8%)
Centrilobular, Congestion 1 (2%)
Centrilobular, Necrosis 2 (3%) 1 (2%) 1 (2%)
Mesentery (18) (14) (15) (20)
Accessory Spleen 1 (6%) 2 (14%) 1 (7%) 1 (5%)
Angiectasis 1 (7%)
Fibrosis 1 (6%) 1 (7%) 1 (5%)
Hemorrhage 1 (6%)
Inflammation, Chronic 1 (7%) 1 (5%)
Fat, Necrosis 12 (67%) 5 (36%) 4 (27%) 16 (80%)
Pancreas (59) (60) (59) (60)
Accessory Spleen 1 (2%) 1 (2%)
Atrophy, Diffuse 1 (2%)
Atrophy, Focal 30 (51%) 32 (53%) 29 (49%) 27 (45%)
Edema 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Necrosis 1 (2%)
Acinar Cell, Focal Cellular Change 1 (2%)
Acinar Cell, Hyperplasia 1 (2%) 2 (3%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Duct, Dilatation 2 (3%)
Salivary Glands (59) (59) (60) (60)
Atrophy, Focal 1 (2%)
Stomach, Forestomach (60) (60) (60) (60)
Edema 1 (2%) 1 (2%) 1 (2%)
Erosion 1 (2%) 1 (2%)
Inflammation, Chronic 2 (3%) 2 (3%) 3 (5%)
Mineralization, Focal 1 (2%)
Ulcer 1 (2%) 2 (3%) 4 (7%)
Mucosa, Hyperplasia 4 (7%) 3 (5%) 5 (8%)
Stomach, Glandular (60) (59) (59) (60)
Erosion 4 (7%) 2 (3%) 1 (2%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Pigmentation, Focal 2 (3%) 1 (2%) 1 (2%)
Mucosa, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Tongue (2)
Hyperplasia, Squamous 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (59) (60) (60) (60)
Mesenteric Artery, Inflammation, Chronic 1 (2%) 1 (2%) 2 (3%)
Heart (60) (60) (60) (60)
Inflammation, Chronic, Focal 1 (2%) 1 (2%) 1 (2%)
Thrombosis 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Accessory Adrenal Cortical Nodule 2 (3%) 1 (2%) 2 (3%) 3 (5%)
Angiectasis 1 (2%) 1 (2%)
Atrophy 1 (2%)
Congestion 2 (3%)
Focal Cellular Change 4 (7%) 7 (12%) 11 (18%) 9 (15%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Adrenal Medulla (60) (60) (60) (60)
Angiectasis 1 (2%)
Hyperplasia 11 (18%) 8 (13%) 15 (25%) 9 (15%)
Pituitary Gland (59) (60) (59) (59)
Angiectasis 1 (2%) 3 (5%) 3 (5%) 4 (7%)
Cyst 3 (5%) 4 (7%) 3 (5%) 4 (7%)
Hemorrhage 1 (2%) 1 (2%)
Pars Distalis, Focal Cellular Change 11 (19%) 6 (10%) 6 (10%) 12 (20%)
Pars Distalis, Hyperplasia, Focal 3 (5%) 7 (12%) 4 (7%) 1 (2%)
Pars Nervosa, Focal Cellular Change 1 (2%)
Thyroid Gland (59) (59) (59) (60)
Degeneration, Cystic 1 (2%) 1 (2%) 2 (3%) 2 (3%)
Ultimobranchial Cyst 2 (3%) 2 (3%)
C-Cell, Hyperplasia 6 (10%) 13 (22%) 5 (8%) 9 (15%)
Follicle, Dilatation 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 2 (3%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (2) (2)
Anterior, Fibrosis 1 (50%)
Anterior, Inflammation, Chronic 1 (50%)
Oral, Inflammation, Chronic 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60) (59) (60)
Inflammation, Chronic 1 (2%) 2 (3%)
Epithelium, Degeneration 1 (2%)
Preputial Gland (60) (60) (59) (60)
Degeneration, Cystic 57 (95%) 57 (95%) 58 (98%) 58 (97%)
Hyperplasia 4 (7%) 1 (2%) 3 (5%)
Inflammation, Chronic 2 (3%) 3 (5%)
Prostate (60) (60) (60) (60)
Hemorrhage 1 (2%)
Inflammation, Suppurative 45 (75%) 37 (62%) 43 (72%) 44 (73%)
Epithelium, Hyperplasia, Focal 1 (2%) 7 (12%) 2 (3%)
Seminal Vesicle (60) (60) (59) (60)
Dilatation 2 (3%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Testes (60) (60) (59) (60)
Congestion 1 (2%)
Mineralization, Focal 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Bilateral, Interstitial Cell, Hyperplasia 2 (3%) 3 (5%) 10 (17%)
Germinal Epithelium, Degeneration 7 (12%) 12 (20%) 13 (22%) 14 (23%)
Interstitial Cell, Hyperplasia 15 (25%) 15 (25%) 9 (15%) 17 (28%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Hemorrhage 2 (3%)
Hypercellularity 5 (8%) 3 (5%) 6 (10%) 5 (8%)
Hyperplasia, Focal, Histiocytic 1 (2%) 1 (2%) 3 (5%)
Metaplasia, Osseous 1 (2%)
Myelofibrosis 2 (3%) 1 (2%) 1 (2%)
Lymph Node (26) (26) (32) (15)
Inguinal, Hyperplasia 1 (3%) 4 (27%)
Lumbar, Hyperplasia 1 (7%)
Mediastinal, Angiectasis 3 (12%) 1 (7%)
Mediastinal, Congestion 3 (12%) 2 (8%) 6 (19%) 5 (33%)
Mediastinal, Hyperplasia 1 (4%) 1 (4%) 1 (3%) 4 (27%)
Mediastinal, Pigmentation 3 (9%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pancreatic, Angiectasis 1 (4%) 1 (3%) 1 (7%)
Pancreatic, Edema 2 (8%) 1 (3%) 1 (7%)
Pancreatic, Hyperplasia 2 (8%) 1 (7%)
Pancreatic, Hyperplasia, Lymphoid 1 (7%)
Pancreatic, Hyperplasia, Macrophage 1 (7%)
Lymph Node, Mandibular (59) (59) (59) (60)
Angiectasis 1 (2%)
Congestion 1 (2%) 1 (2%) 2 (3%) 2 (3%)
Ectasia 1 (2%)
Edema 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 7 (12%) 8 (14%) 7 (12%) 16 (27%)
Lymph Node, Mesenteric (59) (60) (59) (60)
Congestion 1 (2%)
Edema 1 (2%) 1 (2%) 2 (3%) 1 (2%)
Hyperplasia 5 (8%) 3 (5%) 1 (2%) 7 (12%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 3 (5%)
Spleen (60) (60) (60) (60)
Angiectasis 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%)
Degeneration, Fatty 1 (2%)
Fibrosis 12 (20%) 14 (23%) 12 (20%) 7 (12%)
Hematopoietic Cell Proliferation 1 (2%) 2 (3%) 7 (12%) 9 (15%)
Necrosis, Focal 1 (2%) 4 (7%) 1 (2%)
Pigmentation 60 (100%) 60 (100%) 60 (100%) 60 (100%)
Red Pulp, Hyperplasia, Focal, Histiocytic 1 (2%)
Thymus (57) (59) (58) (56)
Congestion 1 (2%)
Cyst 2 (4%)
Hemorrhage 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (57) (58) (54)
Dilatation 19 (32%) 11 (19%) 18 (31%) 9 (17%)
Hemorrhage 2 (4%)
Hyperplasia 6 (10%) 3 (5%) 2 (3%) 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Skin (60) (60) (60) (60)
Cyst Epithelial Inclusion 1 (2%)
Exudate 1 (2%)
Hemorrhage, Focal 1 (2%) 2 (3%) 1 (2%)
Hyperkeratosis, Focal 2 (3%) 4 (7%) 2 (3%)
Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Chronic, Focal 1 (2%) 3 (5%) 2 (3%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Epidermis, Hyperplasia, Focal 2 (3%) 4 (7%) 2 (3%)
Subcutaneous Tissue, Angiectasis 1 (2%)
Subcutaneous Tissue, Congestion 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic,
Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Fracture 1 (2%) 2 (3%)
Hyperostosis 1 (2%) 1 (2%)
Trabecula, Proliferation 1 (2%)
Skeletal Muscle (1) (1) (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 8 (13%) 5 (8%) 5 (8%) 2 (3%)
Hemorrhage 2 (3%) 4 (7%)
Meninges, Fibrosis, Focal 1 (2%)
Spinal Cord (2) (4) (2)
Demyelination 1 (25%)
Hemorrhage, Focal 1 (50%) 1 (25%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Congestion 2 (3%) 2 (3%) 2 (3%)
Edema 1 (2%)
Fibrosis, Focal 1 (2%) 1 (2%)
Hemorrhage, Focal 1 (2%) 3 (5%) 3 (5%)
Hyperplasia, Diffuse, Macrophage 1 (2%)
Hyperplasia, Focal, Macrophage 2 (3%) 2 (3%) 2 (3%)
Infiltration Cellular, Mixed Cell 1 (2%) 2 (3%)
Necrosis, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia 6 (10%) 6 (10%) 7 (12%) 4 (7%)
Nose (60) (60) (60) (60)
Fungus 6 (10%) 9 (15%) 8 (13%) 8 (13%)
Inflammation, Suppurative 8 (13%) 11 (18%) 12 (20%) 9 (15%)
Respiratory Epithelium, Hyperplasia, Focal 1 (2%)
Respiratory Epithelium, Ulcer 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 16:48:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2) (1)
Atrophy 1 (50%) 1 (100%)
Cataract 1 (100%) 2 (100%) 1 (100%)
Retina, Degeneration 1 (100%) 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Autolysis 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%) 1 (2%)
Infarct 1 (2%)
Nephropathy 60 (100%) 60 (100%) 60 (100%) 60 (100%)
Thrombosis 1 (2%)
Pelvis, Dilatation 1 (2%) 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%) 2 (3%)
Renal Tubule, Hyperplasia 3 (5%) 2 (3%) 1 (2%)
Renal Tubule, Hyperplasia, Oncocytic 1 (2%) 1 (2%) 5 (8%)
Renal Tubule, Pigmentation 60 (100%) 60 (100%) 60 (100%) 60 (100%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urinary Bladder (60) (60) (59) (60)
Dilatation 1 (2%)
Hemorrhage 2 (3%) 1 (2%)
Inflammation, Chronic 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
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