TDMS Study 05155-03 Pathology Tables
NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 Facility: Southern Research Institute Chemical CAS #: 62-23-7 Lock Date: 02/15/92 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 6| 6| 7| DAY ON TEST | 3| 0| 3| 4| 2| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 8| 3| 5| 6| 3| 3| 0| 5| 0| 0| | 1| 9| 1| 7| 4| 1| 2| 1| 1| 1| 1| 4| 1| 1| 1| 7| 1| 7| 6| 1| 1| 0| 3| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X X | Leukemia Mononuclear | X X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| Pars Distalis, Adenoma | X X X X X X X X X | Pars Distalis, Carcinoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 6| 6| 7| DAY ON TEST | 3| 0| 3| 4| 2| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 8| 3| 5| 6| 3| 3| 0| 5| 0| 0| | 1| 9| 1| 7| 4| 1| 2| 1| 1| 1| 1| 4| 1| 1| 1| 7| 1| 7| 6| 1| 1| 0| 3| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Leukemia Mononuclear | X| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | X | Leukemia Mononuclear | X X| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| Endometrium, Polyp Stromal | X X | Endometrium, Schwannoma Malignant | | __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| __________________________________________________________________________| Lymph Node | + + + + + + +| Axillary, Leukemia Mononuclear | X X X| Deep Cervical, Leukemia Mononuclear | X| Iliac, Leukemia Mononuclear | X X| Inguinal, Leukemia Mononuclear | X X| Mediastinal, Leukemia Mononuclear | X X X X X X X| Pancreatic, Leukemia Mononuclear | X X X X| Renal, Leukemia Mononuclear | X X| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +| Leukemia Mononuclear | X X X X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | | Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X X X | Leukemia Mononuclear | X X| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 6| 6| 7| DAY ON TEST | 3| 0| 3| 4| 2| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 8| 3| 5| 6| 3| 3| 0| 5| 0| 0| | 1| 9| 1| 7| 4| 1| 2| 1| 1| 1| 1| 4| 1| 1| 1| 7| 1| 7| 6| 1| 1| 0| 3| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Basosquamous Tumor Malignant | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Leukemia | | Mononuclear | X| Subcutaneous Tissue, Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Glioma Malignant | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Peripheral Nerve | + + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | X | Leukemia Mononuclear | X X X X X X X| Mediastinum, Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Leukemia Mononuclear | X| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| DAY ON TEST | 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 2| 6| 5| 3| 9| 3| 3| 7| 3| 7| 6| 3| 3| | 1| 2| 1| 0| 1| 1| 1| 1| 1| 1| 4| 1| 2| 7| 6| 1| 0| 1| 1| 9| 1| 9| 4| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + + | Leukemia Mononuclear | X X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + M + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X| Pars Distalis, Carcinoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X X X X X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| DAY ON TEST | 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 2| 6| 5| 3| 9| 3| 3| 7| 3| 7| 6| 3| 3| | 1| 2| 1| 0| 1| 1| 1| 1| 1| 1| 4| 1| 2| 7| 6| 1| 0| 1| 1| 9| 1| 9| 4| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | | Leukemia Mononuclear | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Endometrium, Polyp Stromal | X X X | Endometrium, Schwannoma Malignant | X | __________________________________________________________________________| Vagina | + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node | + + + + + + | Axillary, Leukemia Mononuclear | X | Deep Cervical, Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | X | Inguinal, Leukemia Mononuclear | X | Mediastinal, Leukemia Mononuclear | X X X X X X | Pancreatic, Leukemia Mononuclear | X X X X X | Renal, Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X | Fibroadenoma | X X X X X X X X X X X| Fibroadenoma, Multiple | X X | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| DAY ON TEST | 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 2| 6| 5| 3| 9| 3| 3| 7| 3| 7| 6| 3| 3| | 1| 2| 1| 0| 1| 1| 1| 1| 1| 1| 4| 1| 2| 7| 6| 1| 0| 1| 1| 9| 1| 9| 4| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Basosquamous Tumor Malignant | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Leukemia | | Mononuclear | | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Glioma Malignant | | Leukemia Mononuclear | X | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | | Leukemia Mononuclear | X X X X X X | Mediastinum, Leukemia Mononuclear | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Leukemia Mononuclear | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0.0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hepatocellular Adenoma | | 2 | Leukemia Mononuclear | | 17 | __________________________________________________________________________|____________| Mesentery | + | 11 | Leukemia Mononuclear | | 6 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 8 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 7 | Pheochromocytoma Benign | | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + M | 57 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0.0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Adenoma | X X | 20 | Pars Distalis, Carcinoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | C-Cell, Adenoma | | 9 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 60 | Adenoma | | 4 | Carcinoma | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 60 | Granulosa Cell Tumor Benign | | 1 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | Endometrium, Polyp Stromal | | 5 | Endometrium, Schwannoma Malignant | | 1 | __________________________________________________________________________|____________| Vagina | | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 10 | __________________________________________________________________________|____________| Lymph Node | + | 14 | Axillary, Leukemia Mononuclear | | 4 | Deep Cervical, Leukemia Mononuclear | | 2 | Iliac, Leukemia Mononuclear | | 3 | Inguinal, Leukemia Mononuclear | | 3 | Mediastinal, Leukemia Mononuclear | | 13 | Pancreatic, Leukemia Mononuclear | | 9 | Renal, Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 13 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 13 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0.0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | | 17 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 60 | Adenoma | | 1 | Carcinoma | | 2 | Fibroadenoma | | 17 | Fibroadenoma, Multiple | | 5 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Basosquamous Tumor Malignant | | 1 | Subcutaneous Tissue, Fibroma | | 2 | Subcutaneous Tissue, Leukemia | | | Mononuclear | | 1 | Subcutaneous Tissue, Lipoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Osteosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Glioma Malignant | | 1 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Peripheral Nerve | | 2 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Carcinoma | | 1 | Leukemia Mononuclear | | 13 | Mediastinum, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Mucosa, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0.0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Eye | + + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 17 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 6| 7| 6| 4| 7| DAY ON TEST | 7| 1| 4| 3| 3| 3| 3| 3| 3| 7| 0| 0| 2| 3| 3| 3| 7| 3| 4| 6| 7| 0| 9| 8| 3| | 4| 0| 1| 1| 1| 1| 1| 1| 1| 6| 8| 2| 8| 1| 1| 1| 0| 1| 8| 5| 4| 2| 5| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.125% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +| Leiomyosarcoma, Metastatic, Uterus | | Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Mesentery | + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Osteosarcoma, Metastatic, Bone | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Osteosarcoma, Metastatic, Bone | X | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 6| 7| 6| 4| 7| DAY ON TEST | 7| 1| 4| 3| 3| 3| 3| 3| 3| 7| 0| 0| 2| 3| 3| 3| 7| 3| 4| 6| 7| 0| 9| 8| 3| | 4| 0| 1| 1| 1| 1| 1| 1| 1| 6| 8| 2| 8| 1| 1| 1| 0| 1| 8| 5| 4| 2| 5| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.125% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Adenoma | X | C-Cell, Adenoma, Multiple | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X X X| Carcinoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Neoplasm NOS | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | Leukemia Mononuclear | X | Endometrium, Polyp Stromal | X X X X | Endometrium, Polyp Stromal, Multiple | X | Endometrium, Sarcoma Stromal | | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node | + + + + | Axillary, Leukemia Mononuclear | | Deep Cervical, Leukemia Mononuclear | | Iliac, Leukemia Mononuclear | | Inguinal, Leukemia Mononuclear | X X | Mediastinal, Leukemia Mononuclear | X X X | Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 6| 7| 6| 4| 7| DAY ON TEST | 7| 1| 4| 3| 3| 3| 3| 3| 3| 7| 0| 0| 2| 3| 3| 3| 7| 3| 4| 6| 7| 0| 9| 8| 3| | 4| 0| 1| 1| 1| 1| 1| 1| 1| 6| 8| 2| 8| 1| 1| 1| 0| 1| 8| 5| 4| 2| 5| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.125% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Carcinoma | X | Fibroadenoma | X X X X X X X X X| Fibroadenoma, Multiple | X X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Schwannoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma NOS | | __________________________________________________________________________| Peripheral Nerve | + | Schwannoma Malignant | | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Osteosarcoma, Multiple, Metastatic, | | Bone | X | Mediastinum, Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 5| 4| 7| 7| 7| 6| 7| 5| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 6| DAY ON TEST | 6| 9| 3| 3| 3| 9| 0| 2| 3| 5| 3| 3| 7| 3| 3| 3| 3| 3| 5| 9| 3| 9| 9| 3| 9| | 6| 6| 1| 1| 1| 6| 0| 1| 1| 0| 1| 1| 4| 1| 1| 2| 1| 1| 1| 6| 1| 6| 6| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.125% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| Leiomyosarcoma, Metastatic, Uterus | X | Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Mesentery | + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| Osteosarcoma, Metastatic, Bone | | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | | Pars Distalis, Adenoma | X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 5| 4| 7| 7| 7| 6| 7| 5| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 6| DAY ON TEST | 6| 9| 3| 3| 3| 9| 0| 2| 3| 5| 3| 3| 7| 3| 3| 3| 3| 3| 5| 9| 3| 9| 9| 3| 9| | 6| 6| 1| 1| 1| 6| 0| 1| 1| 0| 1| 1| 4| 1| 1| 2| 1| 1| 1| 6| 1| 6| 6| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.125% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Adenoma | X X X | C-Cell, Adenoma, Multiple | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| Adenoma | X X X X X | Carcinoma | X X| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| Neoplasm NOS | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | X | Leukemia Mononuclear | X X X| Endometrium, Polyp Stromal | X X X X X X | Endometrium, Polyp Stromal, Multiple | | Endometrium, Sarcoma Stromal | X| __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Lymph Node | + + + + + +| Axillary, Leukemia Mononuclear | X X| Deep Cervical, Leukemia Mononuclear | X| Iliac, Leukemia Mononuclear | X| Inguinal, Leukemia Mononuclear | X| Mediastinal, Leukemia Mononuclear | X X X| Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 5| 4| 7| 7| 7| 6| 7| 5| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 6| DAY ON TEST | 6| 9| 3| 3| 3| 9| 0| 2| 3| 5| 3| 3| 7| 3| 3| 3| 3| 3| 5| 9| 3| 9| 9| 3| 9| | 6| 6| 1| 1| 1| 6| 0| 1| 1| 0| 1| 1| 4| 1| 1| 2| 1| 1| 1| 6| 1| 6| 6| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.125% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Carcinoma | X | Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Schwannoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma NOS | X | __________________________________________________________________________| Peripheral Nerve | + + + | Schwannoma Malignant | X | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| Osteosarcoma, Multiple, Metastatic, | | Bone | | Mediastinum, Leukemia Mononuclear | X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Lacrimal Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0.125% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 58 | Leiomyosarcoma, Metastatic, Uterus | | 1 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 57 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 57 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 12 | __________________________________________________________________________|____________| Mesentery | + | 9 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 6 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | Osteosarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 3 | Osteosarcoma, Metastatic, Bone | | 1 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0.125% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Osteosarcoma, Metastatic, Bone | | 1 | Pars Distalis, Adenoma | X X | 29 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 59 | C-Cell, Adenoma | | 4 | C-Cell, Adenoma, Multiple | | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 59 | Adenoma | | 12 | Carcinoma | | 2 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 4 | Neoplasm NOS | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Leiomyosarcoma | | 1 | Leukemia Mononuclear | | 4 | Endometrium, Polyp Stromal | X X X | 13 | Endometrium, Polyp Stromal, Multiple | | 1 | Endometrium, Sarcoma Stromal | | 1 | __________________________________________________________________________|____________| Vagina | + | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 8 | __________________________________________________________________________|____________| Lymph Node | + + + + | 14 | Axillary, Leukemia Mononuclear | | 2 | Deep Cervical, Leukemia Mononuclear | | 1 | Iliac, Leukemia Mononuclear | | 1 | Inguinal, Leukemia Mononuclear | | 3 | Mediastinal, Leukemia Mononuclear | X | 7 | Pancreatic, Leukemia Mononuclear | | 3 | Renal, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0.125% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | | 9 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 8 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 12 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 58 | Leukemia Mononuclear | | 6 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 60 | Carcinoma | | 2 | Fibroadenoma | X | 16 | Fibroadenoma, Multiple | | 7 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Schwannoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Osteosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Astrocytoma NOS | | 1 | __________________________________________________________________________|____________| Peripheral Nerve | | 4 | Schwannoma Malignant | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 5 | Osteosarcoma, Multiple, Metastatic, | | | Bone | | 1 | Mediastinum, Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0.125% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 3| 7| 6| 6| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| DAY ON TEST | 3| 0| 0| 0| 7| 3| 9| 6| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 9| 5| 3| 9| 3| 3| 4| | 0| 4| 8| 2| 9| 0| 5| 8| 1| 8| 0| 0| 0| 0| 4| 0| 0| 0| 6| 3| 0| 4| 0| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.25% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Sarcoma, Metastatic, Mesentery | | __________________________________________________________________________| Mesentery | + + + | Leukemia Mononuclear | | Sarcoma | | Schwannoma Malignant, Metastatic, | | Uterus | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinar Cell, Adenoma | | __________________________________________________________________________| Pharynx | + | Palate, Squamous Cell Papilloma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 3| 7| 6| 6| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| DAY ON TEST | 3| 0| 0| 0| 7| 3| 9| 6| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 9| 5| 3| 9| 3| 3| 4| | 0| 4| 8| 2| 9| 0| 5| 8| 1| 8| 0| 0| 0| 0| 4| 0| 0| 0| 6| 3| 0| 4| 0| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.25% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| Adenoma | X X X X X X | Carcinoma | X | Bilateral, Adenoma | X | Bilateral, Carcinoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Endometrium, Polyp Stromal | X X X X | Endometrium, Polyp Stromal, Multiple | | Endometrium, Sarcoma Stromal | X | Endometrium, Schwannoma Malignant | X | __________________________________________________________________________| Vagina | + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + | Mediastinal, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X | Renal, Sarcoma, Metastatic, Mesentery| | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | | Leukemia Mononuclear | X | Sarcoma, Metastatic, Mesentery | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | Fibroadenoma | X X X X X X X X X| Fibroadenoma, Multiple | X X X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 3| 7| 6| 6| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| DAY ON TEST | 3| 0| 0| 0| 7| 3| 9| 6| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 9| 5| 3| 9| 3| 3| 4| | 0| 4| 8| 2| 9| 0| 5| 8| 1| 8| 0| 0| 0| 0| 4| 0| 0| 0| 6| 3| 0| 4| 0| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.25% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Rhabdomyosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Pelvis, Transitional Epithelium, | | Mesenchymal Tumor NOS | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 4| 6| 5| 6| 7| 7| 7| 4| 7| 3| 4| 7| 7| 7| 6| 7| 5| 4| 6| 7| 5| 7| 7| 6| DAY ON TEST | 9| 9| 4| 5| 8| 3| 3| 0| 9| 3| 7| 6| 3| 3| 0| 4| 3| 1| 3| 5| 3| 3| 3| 3| 6| | 5| 9| 7| 3| 5| 0| 0| 2| 2| 0| 9| 1| 0| 0| 9| 7| 0| 8| 4| 0| 0| 8| 0| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.25% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Sarcoma, Metastatic, Mesentery | X | __________________________________________________________________________| Mesentery | + + + + + + | Leukemia Mononuclear | X | Sarcoma | X | Schwannoma Malignant, Metastatic, | | Uterus | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| Acinar Cell, Adenoma | X | __________________________________________________________________________| Pharynx | | Palate, Squamous Cell Papilloma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X| C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 4| 6| 5| 6| 7| 7| 7| 4| 7| 3| 4| 7| 7| 7| 6| 7| 5| 4| 6| 7| 5| 7| 7| 6| DAY ON TEST | 9| 9| 4| 5| 8| 3| 3| 0| 9| 3| 7| 6| 3| 3| 0| 4| 3| 1| 3| 5| 3| 3| 3| 3| 6| | 5| 9| 7| 3| 5| 0| 0| 2| 2| 0| 9| 1| 0| 0| 9| 7| 0| 8| 4| 0| 0| 8| 0| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.25% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X| Carcinoma | X X X | Bilateral, Adenoma | | Bilateral, Carcinoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Endometrium, Polyp Stromal | X X X X X X X| Endometrium, Polyp Stromal, Multiple | X | Endometrium, Sarcoma Stromal | | Endometrium, Schwannoma Malignant | X | __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + +| Mediastinal, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X | Renal, Sarcoma, Metastatic, Mesentery| X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | X | Leukemia Mononuclear | X X | Sarcoma, Metastatic, Mesentery | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Fibroadenoma | X X X X X X X X X X | Fibroadenoma, Multiple | X X| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 4| 6| 5| 6| 7| 7| 7| 4| 7| 3| 4| 7| 7| 7| 6| 7| 5| 4| 6| 7| 5| 7| 7| 6| DAY ON TEST | 9| 9| 4| 5| 8| 3| 3| 0| 9| 3| 7| 6| 3| 3| 0| 4| 3| 1| 3| 5| 3| 3| 3| 3| 6| | 5| 9| 7| 3| 5| 0| 0| 2| 2| 0| 9| 1| 0| 0| 9| 7| 0| 8| 4| 0| 0| 8| 0| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.25% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Rhabdomyosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Pelvis, Transitional Epithelium, | | Mesenchymal Tumor NOS | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0.25% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 3 | Sarcoma, Metastatic, Mesentery | | 1 | __________________________________________________________________________|____________| Mesentery | + | 10 | Leukemia Mononuclear | | 1 | Sarcoma | | 1 | Schwannoma Malignant, Metastatic, | | | Uterus | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 59 | Acinar Cell, Adenoma | | 1 | __________________________________________________________________________|____________| Pharynx | | 1 | Palate, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | Pheochromocytoma Benign | | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + | 56 | __________________________________________________________________________|____________| Pituitary Gland | + + + + M + + + + + | 59 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0.25% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Adenoma | X | 26 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | C-Cell, Adenoma | X | 5 | C-Cell, Carcinoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 59 | Adenoma | | 9 | Carcinoma | | 4 | Bilateral, Adenoma | | 1 | Bilateral, Carcinoma | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Histiocytic Sarcoma | | 1 | Endometrium, Polyp Stromal | X X X | 14 | Endometrium, Polyp Stromal, Multiple | | 1 | Endometrium, Sarcoma Stromal | X | 2 | Endometrium, Schwannoma Malignant | | 2 | __________________________________________________________________________|____________| Vagina | | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node | + + | 11 | Mediastinal, Leukemia Mononuclear | | 2 | Pancreatic, Leukemia Mononuclear | | 2 | Renal, Sarcoma, Metastatic, Mesentery| | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Fibrosarcoma | | 1 | Leukemia Mononuclear | | 3 | Sarcoma, Metastatic, Mesentery | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0.25% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 60 | Carcinoma | | 3 | Fibroadenoma | | 19 | Fibroadenoma, Multiple | | 7 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Osteosarcoma | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Rhabdomyosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Peripheral Nerve | | 2 | __________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | | 1 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________|____________| Harderian Gland | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Pelvis, Transitional Epithelium, | | | Mesenchymal Tumor NOS | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0.25% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ Urinary Bladder | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 6| 7| 7| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| DAY ON TEST | 0| 3| 3| 7| 7| 0| 3| 4| 1| 5| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 1| 3| 0| 3| 3| | 8| 0| 0| 4| 4| 2| 0| 1| 8| 6| 0| 0| 8| 0| 0| 0| 0| 0| 1| 0| 1| 0| 9| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + M + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Mesentery | + + + | __________________________________________________________________________| Pancreas | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X| Pars Nervosa, Ganglioneuroma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | | Bilateral, Adenoma | X | Bilateral, Carcinoma | | __________________________________________________________________________| Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + M + + + + + + + + + + + + + + + +| Endometrium, Polyp Stromal | X | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 6| 7| 7| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| DAY ON TEST | 0| 3| 3| 7| 7| 0| 3| 4| 1| 5| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 1| 3| 0| 3| 3| | 8| 0| 0| 4| 4| 2| 0| 1| 8| 6| 0| 0| 8| 0| 0| 0| 0| 0| 1| 0| 1| 0| 9| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | Fibroadenoma | X X X X X X X X X X X | Fibroadenoma, Multiple | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | X | Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Sarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X| Carcinoma, Metastatic, Thyroid Gland | X | Squamous Cell Carcinoma | | Mediastinum, Mesothelioma Malignant | | __________________________________________________________________________| Nose | + + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 6| 7| 7| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| DAY ON TEST | 0| 3| 3| 7| 7| 0| 3| 4| 1| 5| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 1| 3| 0| 3| 3| | 8| 0| 0| 4| 4| 2| 0| 1| 8| 6| 0| 0| 8| 0| 0| 0| 0| 0| 1| 0| 1| 0| 9| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 4| 7| 5| 7| 6| 5| 7| 6| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| 7| DAY ON TEST | 8| 0| 6| 3| 0| 2| 3| 2| 9| 0| 9| 3| 1| 1| 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| | 3| 0| 5| 0| 2| 8| 0| 2| 5| 9| 3| 0| 8| 4| 4| 0| 5| 2| 0| 0| 2| 7| 7| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Mesentery | + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X | Pars Nervosa, Ganglioneuroma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X X X X | Carcinoma | X X X | Bilateral, Adenoma | | Bilateral, Carcinoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Polyp Stromal | X X X X | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 4| 7| 5| 7| 6| 5| 7| 6| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| 7| DAY ON TEST | 8| 0| 6| 3| 0| 2| 3| 2| 9| 0| 9| 3| 1| 1| 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| | 3| 0| 5| 0| 2| 8| 0| 2| 5| 9| 3| 0| 8| 4| 4| 0| 5| 2| 0| 0| 2| 7| 7| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Fibroadenoma | X X X X X X X X| Fibroadenoma, Multiple | X X X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Sarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Carcinoma, Metastatic, Thyroid Gland | | Squamous Cell Carcinoma | X | Mediastinum, Mesothelioma Malignant | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 4| 7| 5| 7| 6| 5| 7| 6| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| 7| DAY ON TEST | 8| 0| 6| 3| 0| 2| 3| 2| 9| 0| 9| 3| 1| 1| 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| | 3| 0| 5| 0| 2| 8| 0| 2| 5| 9| 3| 0| 8| 4| 4| 0| 5| 2| 0| 0| 2| 7| 7| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0.5% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | Carcinoma, Metastatic, Thyroid Gland | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + M + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Mesentery | | 6 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + M | 57 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 59 | Pars Distalis, Adenoma | X X X | 26 | Pars Nervosa, Ganglioneuroma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | C-Cell, Adenoma | | 2 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 60 | Adenoma | | 11 | Carcinoma | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0.5% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Bilateral, Adenoma | | 1 | Bilateral, Carcinoma | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 59 | Endometrium, Polyp Stromal | X | 6 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Lymph Node | + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 60 | Carcinoma | | 2 | Fibroadenoma | | 19 | Fibroadenoma, Multiple | | 5 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Basal Cell Carcinoma | | 1 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | | 3 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | | 1 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Squamous Cell Carcinoma | | 1 | Mediastinum, Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 59 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0.5% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | Carcinoma, Metastatic, Thyroid Gland | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 6| 5| 7| 6| 6| 5| 4| 7| 3| 7| 2| 5| 5| 7| 5| 5| 6| 3| 6| 6| 7| 7| 4| 5| DAY ON TEST | 3| 7| 3| 3| 8| 1| 5| 1| 1| 9| 3| 9| 0| 8| 3| 6| 4| 7| 8| 8| 6| 2| 0| 3| 5| | 0| 3| 5| 0| 9| 7| 6| 9| 0| 2| 0| 9| 3| 4| 0| 1| 1| 4| 1| 0| 8| 9| 2| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + M + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + M + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Liver | + + A + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Acinar Cell, Adenoma | X | __________________________________________________________________________| Pharynx | | Palate, Squamous Cell Papilloma | | __________________________________________________________________________| Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Schwannoma Malignant | X| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + I + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Malignant | X X | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 6| 5| 7| 6| 6| 5| 4| 7| 3| 7| 2| 5| 5| 7| 5| 5| 6| 3| 6| 6| 7| 7| 4| 5| DAY ON TEST | 3| 7| 3| 3| 8| 1| 5| 1| 1| 9| 3| 9| 0| 8| 3| 6| 4| 7| 8| 8| 6| 2| 0| 3| 5| | 0| 3| 5| 0| 9| 7| 6| 9| 0| 2| 0| 9| 3| 4| 0| 1| 1| 4| 1| 0| 8| 9| 2| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pheochromocytoma Benign | X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | Leukemia Mononuclear | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + | Axillary, Leukemia Mononuclear | | Deep Cervical, Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | | Inguinal, Leukemia Mononuclear | X | Mediastinal, Leukemia Mononuclear | X X X X X X X X | Pancreatic, Leukemia Mononuclear | X X X X | Popliteal, Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 6| 5| 7| 6| 6| 5| 4| 7| 3| 7| 2| 5| 5| 7| 5| 5| 6| 3| 6| 6| 7| 7| 4| 5| DAY ON TEST | 3| 7| 3| 3| 8| 1| 5| 1| 1| 9| 3| 9| 0| 8| 3| 6| 4| 7| 8| 8| 6| 2| 0| 3| 5| | 0| 3| 5| 0| 9| 7| 6| 9| 0| 2| 0| 9| 3| 4| 0| 1| 1| 4| 1| 0| 8| 9| 2| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Epithelial Cell, Thymoma Benign | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X X | Subcutaneous Tissue, Fibroma | X X X | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Leukemia | | Mononuclear | | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Schwannoma Malignant, Metastatic, | | Peripheral Nerve | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Glioma Malignant | X | Leukemia Mononuclear | X | __________________________________________________________________________| Peripheral Nerve | + | Schwannoma Malignant | X | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Mediastinum, Leukemia Mononuclear | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Leukemia Mononuclear | | Nasolacrimal Duct, Squamous Cell | | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 6| 5| 7| 6| 6| 5| 4| 7| 3| 7| 2| 5| 5| 7| 5| 5| 6| 3| 6| 6| 7| 7| 4| 5| DAY ON TEST | 3| 7| 3| 3| 8| 1| 5| 1| 1| 9| 3| 9| 0| 8| 3| 6| 4| 7| 8| 8| 6| 2| 0| 3| 5| | 0| 3| 5| 0| 9| 7| 6| 9| 0| 2| 0| 9| 3| 4| 0| 1| 1| 4| 1| 0| 8| 9| 2| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Carcinoma | X | __________________________________________________________________________| Trachea | + + M + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + + | Adenoma | X | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pelvis, Transitional Epithelium, | | Papilloma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 5| 7| 6| 5| 6| 5| 6| 7| 5| 4| DAY ON TEST | 4| 3| 1| 0| 4| 5| 2| 8| 1| 2| 3| 3| 4| 3| 3| 8| 2| 8| 0| 3| 1| 7| 2| 4| 5| | 5| 0| 4| 2| 5| 1| 9| 9| 7| 2| 0| 0| 7| 0| 0| 8| 4| 0| 5| 1| 7| 3| 9| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | Leukemia Mononuclear | X X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Acinar Cell, Adenoma | X | __________________________________________________________________________| Pharynx | + | Palate, Squamous Cell Papilloma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Schwannoma Malignant | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Pheochromocytoma Malignant | | _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 5| 7| 6| 5| 6| 5| 6| 7| 5| 4| DAY ON TEST | 4| 3| 1| 0| 4| 5| 2| 8| 1| 2| 3| 3| 4| 3| 3| 8| 2| 8| 0| 3| 1| 7| 2| 4| 5| | 5| 0| 4| 2| 5| 1| 9| 9| 7| 2| 0| 0| 7| 0| 0| 8| 4| 0| 5| 1| 7| 3| 9| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + M| Leukemia Mononuclear | X | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pars Distalis, Adenoma | X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | +| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + | Axillary, Leukemia Mononuclear | X X X | Deep Cervical, Leukemia Mononuclear | X X X | Iliac, Leukemia Mononuclear | X X X | Inguinal, Leukemia Mononuclear | X X X X | Mediastinal, Leukemia Mononuclear | X X X X X X X X X X X X | Pancreatic, Leukemia Mononuclear | X X X X X X X X X | Popliteal, Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 5| 7| 6| 5| 6| 5| 6| 7| 5| 4| DAY ON TEST | 4| 3| 1| 0| 4| 5| 2| 8| 1| 2| 3| 3| 4| 3| 3| 8| 2| 8| 0| 3| 1| 7| 2| 4| 5| | 5| 0| 4| 2| 5| 1| 9| 9| 7| 2| 0| 0| 7| 0| 0| 8| 4| 0| 5| 1| 7| 3| 9| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + M + + M| Leukemia Mononuclear | X X X X X X X X | Epithelial Cell, Thymoma Benign | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| Fibroadenoma | X | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Leukemia | | Mononuclear | X X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Schwannoma Malignant, Metastatic, | | Peripheral Nerve | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Glioma Malignant | | Leukemia Mononuclear | X X | __________________________________________________________________________| Peripheral Nerve | + | Schwannoma Malignant | | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Mediastinum, Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Leukemia Mononuclear | X X | Nasolacrimal Duct, Squamous Cell | | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 5| 7| 6| 5| 6| 5| 6| 7| 5| 4| DAY ON TEST | 4| 3| 1| 0| 4| 5| 2| 8| 1| 2| 3| 3| 4| 3| 3| 8| 2| 8| 0| 3| 1| 7| 2| 4| 5| | 5| 0| 4| 2| 5| 1| 9| 9| 7| 2| 0| 0| 7| 0| 0| 8| 4| 0| 5| 1| 7| 3| 9| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Carcinoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | Adenoma | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Pelvis, Transitional Epithelium, | | Papilloma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | X | Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 59 | Hemangiosarcoma | | 1 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 58 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 59 | Carcinoma | | 2 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 58 | Leukemia Mononuclear | | 7 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 59 | Hepatocellular Carcinoma | | 3 | Hepatocellular Adenoma | | 2 | Leukemia Mononuclear | | 27 | __________________________________________________________________________|____________| Mesentery | + | 18 | Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 5 | Acinar Cell, Adenoma | | 2 | __________________________________________________________________________|____________| Pharynx | | 1 | Palate, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 2 | Schwannoma Malignant | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 8 | Pheochromocytoma Malignant | | 2 | Pheochromocytoma Benign | | 8 | Bilateral, Pheochromocytoma Benign | | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 59 | Adenoma | | 2 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 57 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 5 | Pars Distalis, Adenoma | X | 20 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 1 | C-Cell, Adenoma | | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 60 | Adenoma | X | 4 | Carcinoma | | 1 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | Bilateral, Interstitial Cell, Adenoma| X X X | 38 | Interstitial Cell, Adenoma | X X X X X | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 17 | __________________________________________________________________________|____________| Lymph Node | + + | 26 | Axillary, Leukemia Mononuclear | | 3 | Deep Cervical, Leukemia Mononuclear | | 4 | Iliac, Leukemia Mononuclear | | 3 | Inguinal, Leukemia Mononuclear | | 5 | Mediastinal, Leukemia Mononuclear | | 20 | Pancreatic, Leukemia Mononuclear | | 13 | Popliteal, Leukemia Mononuclear | | 1 | Renal, Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 21 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 22 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 29 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 57 | Leukemia Mononuclear | | 13 | Epithelial Cell, Thymoma Benign | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 59 | Fibroadenoma | X | 3 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Keratoacanthoma | | 3 | Subcutaneous Tissue, Fibroma | | 4 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Leukemia | | | Mononuclear | | 2 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Schwannoma Malignant, Metastatic, | | | Peripheral Nerve | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 51 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Glioma Malignant | | 1 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Peripheral Nerve | | 2 | Schwannoma Malignant | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 14 | Mediastinum, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Mucosa, Leukemia Mononuclear | | 2 | Nasolacrimal Duct, Squamous Cell | | | Carcinoma | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 2 | Adenoma | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 12 | Pelvis, Transitional Epithelium, | | | Papilloma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Leiomyosarcoma | | 1 | Leukemia Mononuclear | | 6 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 29 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 6| 7| 3| 7| 6| 7| 6| 5| 7| 7| 5| 6| 7| 6| 7| 6| 5| 4| 7| 7| 7| DAY ON TEST | 7| 3| 3| 2| 0| 2| 9| 2| 7| 0| 7| 0| 2| 0| 8| 2| 2| 3| 0| 5| 2| 5| 2| 2| 2| | 4| 2| 2| 9| 2| 9| 2| 9| 4| 0| 3| 5| 8| 2| 4| 4| 9| 7| 0| 2| 7| 4| 2| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Hepatocellular Adenoma, Multiple | X | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + + + + | Leukemia Mononuclear | X X X X X X | Mesothelioma Malignant | X | Schwannoma Malignant, Metastatic, | | Peripheral Nerve | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Schwannoma Malignant, Metastatic, | | Peripheral Nerve | | Acinar Cell, Adenoma | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Benign | X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 6| 7| 3| 7| 6| 7| 6| 5| 7| 7| 5| 6| 7| 6| 7| 6| 5| 4| 7| 7| 7| DAY ON TEST | 7| 3| 3| 2| 0| 2| 9| 2| 7| 0| 7| 0| 2| 0| 8| 2| 2| 3| 0| 5| 2| 5| 2| 2| 2| | 4| 2| 2| 9| 2| 9| 2| 9| 4| 0| 3| 5| 8| 2| 4| 4| 9| 7| 0| 2| 7| 4| 2| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Thoracic, Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | Bilateral, Adenoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Schwannoma Malignant, Metastatic, | | Peripheral Nerve | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + | Iliac, Leukemia Mononuclear | X X | Inguinal, Leukemia Mononuclear | X X | Mediastinal, Leukemia Mononuclear | X X X X X X X X X X X | Pancreatic, Leukemia Mononuclear | X X X X X X X X X X | Renal, Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 6| 7| 3| 7| 6| 7| 6| 5| 7| 7| 5| 6| 7| 6| 7| 6| 5| 4| 7| 7| 7| DAY ON TEST | 7| 3| 3| 2| 0| 2| 9| 2| 7| 0| 7| 0| 2| 0| 8| 2| 2| 3| 0| 5| 2| 5| 2| 2| 2| | 4| 2| 2| 9| 2| 9| 2| 9| 4| 0| 3| 5| 8| 2| 4| 4| 9| 7| 0| 2| 7| 4| 2| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Epithelial Cell, Thymoma Benign | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X X | Subcutaneous Tissue, Fibroma | X X X| Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Peripheral Nerve | + + | Schwannoma Malignant | | __________________________________________________________________________| Spinal Cord | + + | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | | Leukemia Mononuclear | X X X X X X | Osteosarcoma, Multiple, Metastatic, | | Bone | | Mediastinum, Leukemia Mononuclear | X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Leukemia Mononuclear | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Pinna, Fibrosarcoma | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 6| 7| 3| 7| 6| 7| 6| 5| 7| 7| 5| 6| 7| 6| 7| 6| 5| 4| 7| 7| 7| DAY ON TEST | 7| 3| 3| 2| 0| 2| 9| 2| 7| 0| 7| 0| 2| 0| 8| 2| 2| 3| 0| 5| 2| 5| 2| 2| 2| | 4| 2| 2| 9| 2| 9| 2| 9| 4| 0| 3| 5| 8| 2| 4| 4| 9| 7| 0| 2| 7| 4| 2| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Schwannoma Malignant, Metastatic, | | Peripheral Nerve | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 4| 4| 6| 5| 6| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 5| 7| 5| 7| 6| 7| 5| 3| 7| DAY ON TEST | 2| 1| 9| 6| 3| 3| 2| 6| 7| 2| 0| 7| 2| 2| 2| 9| 8| 2| 3| 2| 4| 1| 8| 1| 2| | 8| 5| 3| 5| 9| 1| 9| 1| 3| 9| 2| 3| 9| 9| 9| 1| 8| 2| 8| 9| 7| 0| 7| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + M + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X X | Hepatocellular Adenoma, Multiple | X | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + | Leukemia Mononuclear | X X X X | Mesothelioma Malignant | | Schwannoma Malignant, Metastatic, | | Peripheral Nerve | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Schwannoma Malignant, Metastatic, | | Peripheral Nerve | X | Acinar Cell, Adenoma | X | __________________________________________________________________________| Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Pheochromocytoma Benign | X X X | Bilateral, Pheochromocytoma Benign | X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 4| 4| 6| 5| 6| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 5| 7| 5| 7| 6| 7| 5| 3| 7| DAY ON TEST | 2| 1| 9| 6| 3| 3| 2| 6| 7| 2| 0| 7| 2| 2| 2| 9| 8| 2| 3| 2| 4| 1| 8| 1| 2| | 8| 5| 3| 5| 9| 1| 9| 1| 3| 9| 2| 3| 9| 9| 9| 1| 8| 2| 8| 9| 7| 0| 7| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X | Pars Intermedia, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Thoracic, Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | Bilateral, Adenoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Schwannoma Malignant, Metastatic, | | Peripheral Nerve | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + | Iliac, Leukemia Mononuclear | | Inguinal, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | X X X X X X X | Pancreatic, Leukemia Mononuclear | X X X X X X | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 4| 4| 6| 5| 6| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 5| 7| 5| 7| 6| 7| 5| 3| 7| DAY ON TEST | 2| 1| 9| 6| 3| 3| 2| 6| 7| 2| 0| 7| 2| 2| 2| 9| 8| 2| 3| 2| 4| 1| 8| 1| 2| | 8| 5| 3| 5| 9| 1| 9| 1| 3| 9| 2| 3| 9| 9| 9| 1| 8| 2| 8| 9| 7| 0| 7| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Epithelial Cell, Thymoma Benign | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | X X X | Subcutaneous Tissue, Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Peripheral Nerve | + + + | Schwannoma Malignant | X | __________________________________________________________________________| Spinal Cord | + + | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | X | Leukemia Mononuclear | X X X X X X X X X | Osteosarcoma, Multiple, Metastatic, | | Bone | X | Mediastinum, Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Leukemia Mononuclear | X | __________________________________________________________________________| Trachea | + M + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | Pinna, Fibrosarcoma | X | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 4| 4| 6| 5| 6| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 5| 7| 5| 7| 6| 7| 5| 3| 7| DAY ON TEST | 2| 1| 9| 6| 3| 3| 2| 6| 7| 2| 0| 7| 2| 2| 2| 9| 8| 2| 3| 2| 4| 1| 8| 1| 2| | 8| 5| 3| 5| 9| 1| 9| 1| 3| 9| 2| 3| 9| 9| 9| 1| 8| 2| 8| 9| 7| 0| 7| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Schwannoma Malignant, Metastatic, | | Peripheral Nerve | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hepatocellular Adenoma | | 2 | Hepatocellular Adenoma, Multiple | | 2 | Leukemia Mononuclear | X | 36 | __________________________________________________________________________|____________| Mesentery | + | 14 | Leukemia Mononuclear | | 10 | Mesothelioma Malignant | | 1 | Schwannoma Malignant, Metastatic, | | | Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 7 | Schwannoma Malignant, Metastatic, | | | Peripheral Nerve | | 1 | Acinar Cell, Adenoma | | 3 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 9 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 9 | Pheochromocytoma Benign | | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Bilateral, Pheochromocytoma Benign | | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 3 | Pars Distalis, Adenoma | X X | 14 | Pars Intermedia, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 59 | C-Cell, Adenoma | | 2 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 2 | Thoracic, Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | Mesothelioma Malignant | | 2 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 60 | Adenoma | | 2 | Carcinoma | | 1 | Bilateral, Adenoma | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | Schwannoma Malignant, Metastatic, | | | Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X | 43 | Interstitial Cell, Adenoma | X | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 21 | __________________________________________________________________________|____________| Lymph Node | | 26 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Iliac, Leukemia Mononuclear | | 2 | Inguinal, Leukemia Mononuclear | | 2 | Mediastinal, Leukemia Mononuclear | | 18 | Pancreatic, Leukemia Mononuclear | | 16 | Renal, Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 59 | Leukemia Mononuclear | X | 19 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 26 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 35 | __________________________________________________________________________|____________| Thymus | + + M + + + + + + + | 59 | Leukemia Mononuclear | | 17 | Epithelial Cell, Thymoma Benign | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + + M + | 57 | Fibroadenoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Keratoacanthoma | | 3 | Subcutaneous Tissue, Fibroma | | 6 | Subcutaneous Tissue, Lipoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Osteosarcoma | | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Peripheral Nerve | | 5 | Schwannoma Malignant | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 4 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Carcinoma | | 1 | Leukemia Mononuclear | X | 16 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Osteosarcoma, Multiple, Metastatic, | | | Bone | | 1 | Mediastinum, Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Mucosa, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | Pinna, Fibrosarcoma | | 1 | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | Schwannoma Malignant, Metastatic, | | | Peripheral Nerve | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 36 | Mesothelioma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 6| 7| 5| 7| 5| 5| 7| 6| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 4| 0| 0| 2| 7| 2| 1| 2| 3| 0| 2| 6| 2| 4| 2| 0| 7| 0| 7| 2| 2| 2| 0| 2| | 9| 1| 9| 2| 2| 2| 9| 7| 9| 2| 5| 9| 8| 9| 3| 9| 4| 3| 4| 9| 9| 8| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| Leukemia Mononuclear | X | Polyp Adenomatous | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X X X | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Mesentery | + + + + + + | Carcinoma, Metastatic, Kidney | X | Leukemia Mononuclear | X X | Mesothelioma Benign | X | Mesothelioma Malignant | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Pharynx | + + | Palate, Squamous Cell Papilloma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | X | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 6| 7| 5| 7| 5| 5| 7| 6| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 4| 0| 0| 2| 7| 2| 1| 2| 3| 0| 2| 6| 2| 4| 2| 0| 7| 0| 7| 2| 2| 2| 0| 2| | 9| 1| 9| 2| 2| 2| 9| 7| 9| 2| 5| 9| 8| 9| 3| 9| 4| 3| 4| 9| 9| 8| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X | Bilateral, Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +| Adenoma | X X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + A M M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + M + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| Adenoma | X X | Carcinoma | X X | Bilateral, Carcinoma | | Duct, Squamous Cell Papilloma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + M + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + M + + + + + + +| Leukemia Mononuclear | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + | Axillary, Leukemia Mononuclear | X | Deep Cervical, Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | X | Inguinal, Leukemia Mononuclear | X X | Mediastinal, Carcinoma, Metastatic, | | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 6| 7| 5| 7| 5| 5| 7| 6| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 4| 0| 0| 2| 7| 2| 1| 2| 3| 0| 2| 6| 2| 4| 2| 0| 7| 0| 7| 2| 2| 2| 0| 2| | 9| 1| 9| 2| 2| 2| 9| 7| 9| 2| 5| 9| 8| 9| 3| 9| 4| 3| 4| 9| 9| 8| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Kidney | X | Mediastinal, Leukemia Mononuclear | X X X X X X X | Pancreatic, Carcinoma, Metastatic, | | Kidney | X | Pancreatic, Leukemia Mononuclear | X X X X | Renal, Carcinoma, Metastatic, Kidney | X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + A + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + + + + + + +| Carcinoma, Metastatic, Kidney | X | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Epithelial Cell, Thymoma Benign | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Keratoacanthoma | X | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X X X X | Subcutaneous Tissue, Leukemia | | Mononuclear | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | Meninges, Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 6| 7| 5| 7| 5| 5| 7| 6| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 4| 0| 0| 2| 7| 2| 1| 2| 3| 0| 2| 6| 2| 4| 2| 0| 7| 0| 7| 2| 2| 2| 0| 2| | 9| 1| 9| 2| 2| 2| 9| 7| 9| 2| 5| 9| 8| 9| 3| 9| 4| 3| 4| 9| 9| 8| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar/Bronchiolar Adenoma | X | Carcinoma, Multiple, Metastatic, | | Kidney | X | Leukemia Mononuclear | X X X X X | Osteosarcoma, Multiple, Metastatic, | | Bone | | Mediastinum, Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Leukemia Mononuclear | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Renal Tubule, Adenoma | | Renal Tubule, Carcinoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | Mesothelioma Benign | X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 4| 6| 7| 6| 7| 6| 7| 6| 5| 7| 5| 5| DAY ON TEST | 2| 3| 0| 7| 8| 9| 2| 6| 7| 7| 0| 5| 2| 2| 8| 0| 7| 2| 5| 0| 3| 0| 2| 5| 7| | 9| 2| 6| 3| 8| 6| 8| 8| 4| 4| 6| 1| 9| 6| 7| 0| 9| 9| 7| 2| 1| 6| 9| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Polyp Adenomatous | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | Osteosarcoma, Metastatic, Bone | X| __________________________________________________________________________| Mesentery | + + + + + + + | Carcinoma, Metastatic, Kidney | | Leukemia Mononuclear | X X X | Mesothelioma Benign | | Mesothelioma Malignant | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Pharynx | + | Palate, Squamous Cell Papilloma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| Page 69 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 4| 6| 7| 6| 7| 6| 7| 6| 5| 7| 5| 5| DAY ON TEST | 2| 3| 0| 7| 8| 9| 2| 6| 7| 7| 0| 5| 2| 2| 8| 0| 7| 2| 5| 0| 3| 0| 2| 5| 7| | 9| 2| 6| 3| 8| 6| 8| 8| 4| 4| 6| 1| 9| 6| 7| 0| 9| 9| 7| 2| 1| 6| 9| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X | Bilateral, Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + I + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X | Bilateral, Carcinoma | X | Duct, Squamous Cell Papilloma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + | Axillary, Leukemia Mononuclear | X X X | Deep Cervical, Leukemia Mononuclear | X X X | Iliac, Leukemia Mononuclear | X X X X | Inguinal, Leukemia Mononuclear | X X X X X | Mediastinal, Carcinoma, Metastatic, | | _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 4| 6| 7| 6| 7| 6| 7| 6| 5| 7| 5| 5| DAY ON TEST | 2| 3| 0| 7| 8| 9| 2| 6| 7| 7| 0| 5| 2| 2| 8| 0| 7| 2| 5| 0| 3| 0| 2| 5| 7| | 9| 2| 6| 3| 8| 6| 8| 8| 4| 4| 6| 1| 9| 6| 7| 0| 9| 9| 7| 2| 1| 6| 9| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Kidney | | Mediastinal, Leukemia Mononuclear | X X X X X X X X X X X X X | Pancreatic, Carcinoma, Metastatic, | | Kidney | | Pancreatic, Leukemia Mononuclear | X X X X X X X X X | Renal, Carcinoma, Metastatic, Kidney | | Renal, Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | Epithelial Cell, Thymoma Benign | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Keratoacanthoma | X X | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Leukemia | | Mononuclear | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X| __________________________________________________________________________| Skeletal Muscle | + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + + | Meninges, Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 4| 6| 7| 6| 7| 6| 7| 6| 5| 7| 5| 5| DAY ON TEST | 2| 3| 0| 7| 8| 9| 2| 6| 7| 7| 0| 5| 2| 2| 8| 0| 7| 2| 5| 0| 3| 0| 2| 5| 7| | 9| 2| 6| 3| 8| 6| 8| 8| 4| 4| 6| 1| 9| 6| 7| 0| 9| 9| 7| 2| 1| 6| 9| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar/Bronchiolar Adenoma | | Carcinoma, Multiple, Metastatic, | | Kidney | | Leukemia Mononuclear | X X X X X X X X X X X | Osteosarcoma, Multiple, Metastatic, | | Bone | X| Mediastinum, Leukemia Mononuclear | X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Leukemia Mononuclear | X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Renal Tubule, Adenoma | X | Renal Tubule, Carcinoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X | Mesothelioma Benign | | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 72 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 1 | Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 6 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hepatocellular Adenoma | | 1 | Leukemia Mononuclear | | 25 | Osteosarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Mesentery | + + | 15 | Carcinoma, Metastatic, Kidney | | 1 | Leukemia Mononuclear | | 5 | Mesothelioma Benign | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Pharynx | | 3 | Palate, Squamous Cell Papilloma | | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 59 | Leiomyoma | | 1 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 73 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Adenoma | | 1 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 6 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X | 6 | Bilateral, Pheochromocytoma Benign | | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 59 | Adenoma | | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 57 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 4 | Pars Distalis, Adenoma | X X X X | 20 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 59 | C-Cell, Adenoma | | 2 | C-Cell, Carcinoma | | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 59 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 59 | Adenoma | X | 5 | Carcinoma | | 3 | Bilateral, Carcinoma | | 1 | Duct, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 3 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X | 42 | Interstitial Cell, Adenoma | X X | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 74 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 19 | __________________________________________________________________________|____________| Lymph Node | + + | 32 | Axillary, Leukemia Mononuclear | | 4 | Deep Cervical, Leukemia Mononuclear | | 4 | Iliac, Leukemia Mononuclear | | 5 | Inguinal, Leukemia Mononuclear | | 7 | Mediastinal, Carcinoma, Metastatic, | | | Kidney | | 1 | Mediastinal, Leukemia Mononuclear | | 20 | Pancreatic, Carcinoma, Metastatic, | | | Kidney | | 1 | Pancreatic, Leukemia Mononuclear | | 13 | Renal, Carcinoma, Metastatic, Kidney | | 1 | Renal, Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 20 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 59 | Carcinoma, Metastatic, Kidney | | 1 | Leukemia Mononuclear | | 24 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Fibrosarcoma | | 1 | Leukemia Mononuclear | | 26 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 58 | Leukemia Mononuclear | | 17 | Epithelial Cell, Thymoma Benign | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + M + + | 58 | Fibroadenoma | | 4 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Basal Cell Adenoma | | 1 | Keratoacanthoma | | 3 | Squamous Cell Papilloma | | 2 | Subcutaneous Tissue, Fibroma | | 4 | Subcutaneous Tissue, Leukemia | | | Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 75 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Osteosarcoma | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 2 | Meninges, Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | | 1 | Carcinoma, Multiple, Metastatic, | | | Kidney | | 1 | Leukemia Mononuclear | | 16 | Osteosarcoma, Multiple, Metastatic, | | | Bone | | 1 | Mediastinum, Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Mucosa, Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 2 | __________________________________________________________________________|____________| Eye | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 4 | Renal Tubule, Adenoma | | 1 | Renal Tubule, Carcinoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 76 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Leukemia Mononuclear | | 26 | Mesothelioma Benign | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 77 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 5| 7| 6| 4| 7| 7| 7| 1| 4| 7| 6| 7| 7| 5| 7| 5| 6| 7| 7| 6| 5| DAY ON TEST | 1| 2| 2| 2| 4| 1| 1| 8| 2| 2| 2| 9| 5| 2| 1| 1| 0| 0| 2| 0| 9| 2| 2| 1| 4| | 8| 9| 9| 9| 2| 0| 5| 3| 9| 9| 9| 1| 8| 9| 8| 0| 3| 6| 9| 6| 5| 9| 9| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0.5% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Hepatocellular Adenoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Mesentery | + + + + + + | Leukemia Mononuclear | | Mesothelioma Malignant | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pheochromocytoma Malignant | X X | Pheochromocytoma Benign | X X X | Bilateral, Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 5| 7| 6| 4| 7| 7| 7| 1| 4| 7| 6| 7| 7| 5| 7| 5| 6| 7| 7| 6| 5| DAY ON TEST | 1| 2| 2| 2| 4| 1| 1| 8| 2| 2| 2| 9| 5| 2| 1| 1| 0| 0| 2| 0| 9| 2| 2| 1| 4| | 8| 9| 9| 9| 2| 0| 5| 3| 9| 9| 9| 1| 8| 9| 8| 0| 3| 6| 9| 6| 5| 9| 9| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0.5% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Carcinoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X X | Bilateral, Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X | Interstitial Cell, Adenoma | X X X X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + | Mediastinal, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X | Mesothelioma Malignant | | __________________________________________________________________________| Thymus | + + + + + + + + + + + M + + + + + M + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Keratoacanthoma | | Trichoepithelioma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | X X X X | _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 5| 7| 6| 4| 7| 7| 7| 1| 4| 7| 6| 7| 7| 5| 7| 5| 6| 7| 7| 6| 5| DAY ON TEST | 1| 2| 2| 2| 4| 1| 1| 8| 2| 2| 2| 9| 5| 2| 1| 1| 0| 0| 2| 0| 9| 2| 2| 1| 4| | 8| 9| 9| 9| 2| 0| 5| 3| 9| 9| 9| 1| 8| 9| 8| 0| 3| 6| 9| 6| 5| 9| 9| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0.5% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Subcutaneous Tissue, Lipoma | X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Leukemia Mononuclear | | Squamous Cell Carcinoma | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 80 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 6| 7| 7| DAY ON TEST | 3| 2| 2| 4| 2| 2| 2| 9| 8| 1| 6| 2| 2| 9| 2| 2| 3| 5| 0| 4| 2| 0| 8| 2| 2| | 2| 9| 9| 7| 9| 9| 9| 4| 9| 9| 7| 9| 9| 6| 0| 9| 4| 4| 0| 5| 9| 8| 1| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.5% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Hepatocellular Adenoma | X X | Leukemia Mononuclear | X | __________________________________________________________________________| Mesentery | + + + + + + + + + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + I + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | _____________________________________________________________________________________________________________________| Page 81 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 6| 7| 7| DAY ON TEST | 3| 2| 2| 4| 2| 2| 2| 9| 8| 1| 6| 2| 2| 9| 2| 2| 3| 5| 0| 4| 2| 0| 8| 2| 2| | 2| 9| 9| 7| 9| 9| 9| 4| 9| 9| 7| 9| 9| 6| 0| 9| 4| 4| 0| 5| 9| 8| 1| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.5% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Carcinoma | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X X | Bilateral, Carcinoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + | Mediastinal, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X | Mesothelioma Malignant | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + M + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M + + + + + + + + M + + + M + + + + + + + +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Keratoacanthoma | X X | Trichoepithelioma | | Subcutaneous Tissue, Fibroma | X X X X X X | Subcutaneous Tissue, Fibrosarcoma | | _____________________________________________________________________________________________________________________| Page 82 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 _____________________________________________________________________________________________________________________ | 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 6| 7| 7| DAY ON TEST | 3| 2| 2| 4| 2| 2| 2| 9| 8| 1| 6| 2| 2| 9| 2| 2| 3| 5| 0| 4| 2| 0| 8| 2| 2| | 2| 9| 9| 7| 9| 9| 9| 4| 9| 9| 7| 9| 9| 6| 0| 9| 4| 4| 0| 5| 9| 8| 1| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.5% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Leukemia Mononuclear | X | Squamous Cell Carcinoma | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 83 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0.5% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Colon | + M + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hepatocellular Carcinoma | | 2 | Hepatocellular Adenoma | | 2 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Mesentery | + + + | 20 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Schwannoma Malignant | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Tongue | | 2 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | Pheochromocytoma Malignant | | 2 | Pheochromocytoma Benign | | 11 | Bilateral, Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 84 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0.5% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 59 | Pars Distalis, Adenoma | X | 13 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | C-Cell, Adenoma | | 3 | C-Cell, Carcinoma | | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 60 | Adenoma | X | 4 | Carcinoma | | 5 | Bilateral, Carcinoma | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| | 21 | Interstitial Cell, Adenoma | X | 16 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Lymph Node | + | 15 | Mediastinal, Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | | 1 | Renal, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Histiocytic Sarcoma | X | 2 | Leukemia Mononuclear | | 2 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 56 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 85 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0.5% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M + + + + + + + | 54 | Fibroadenoma | | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Basal Cell Adenoma | | 1 | Keratoacanthoma | | 2 | Trichoepithelioma | | 1 | Subcutaneous Tissue, Fibroma | | 7 | Subcutaneous Tissue, Fibrosarcoma | | 4 | Subcutaneous Tissue, Lipoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Osteosarcoma | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | X | 3 | Leukemia Mononuclear | | 1 | Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Histiocytic Sarcoma | X | 2 | Leukemia Mononuclear | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 86 NTP Experiment-Test: 05155-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC P-NITROBENZOIC ACID Date: 03/31/97 Route: DOSED FEED Time: 14:28:23 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0.5% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 87 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------