TDMS Study 05155-03 Pathology Tables
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
Facility: Southern Research Institute
Chemical CAS #: 62-23-7
Lock Date: 02/15/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 0| 3| 4| 2| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 8| 3| 5| 6| 3| 3| 0| 5| 0| 0|
| 1| 9| 1| 7| 4| 1| 2| 1| 1| 1| 1| 4| 1| 1| 1| 7| 1| 7| 6| 1| 1| 0| 3| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X |
Fatty Change | 3 3 3 2 1 2 2 2 2|
Fibrosis, Focal | |
Focal Cellular Change | 2 |
Hepatodiaphragmatic Nodule | 2 2 2 |
Hyperplasia, Multifocal | 2 2 3 2 2|
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 1 1 2 1 1 1 1 1 1 1 1 2 |
Mixed Cell Focus | X X |
Necrosis, Focal | 1 |
Pigmentation | 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 1 1 3 2 2 1 1 2 1 1 1 2 1|
Centrilobular, Atrophy | 3 3 3 2 2 2 2 2 2 3|
Centrilobular, Hemorrhage | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Atrophy, Diffuse | 3 |
Atrophy, Focal | 2 2 1 1 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Inflammation, Chronic | 3 |
Ulcer | 3 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Erosion | 1 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 0| 3| 4| 2| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 8| 3| 5| 6| 3| 3| 0| 5| 0| 0|
| 1| 9| 1| 7| 4| 1| 2| 1| 1| 1| 1| 4| 1| 1| 1| 7| 1| 7| 6| 1| 1| 0| 3| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
__________________________________________________________________________|
Tooth | + |
Gingiva, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Inflammation, | |
Chronic | 4 |
Mesenteric Artery, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Embolus | |
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | |
Congestion | 2 2 3|
Depletion Cellular | |
Focal Cellular Change | 1 2 2 2 1 2 |
Hyperplasia, Focal | |
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 2 3 |
Cyst | 1 |
Granuloma | |
Hemorrhage | |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 3 2 2 3 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
C-Cell, Hyperplasia | 2 1 2 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 0| 3| 4| 2| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 8| 3| 5| 6| 3| 3| 0| 5| 0| 0|
| 1| 9| 1| 7| 4| 1| 2| 1| 1| 1| 1| 4| 1| 1| 1| 7| 1| 7| 6| 1| 1| 0| 3| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Degeneration, Cystic | 1 2 2 3 1 1 2 1 1 1 1 1 2 1 1 1 1 2 2 1|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 2 4 |
Hemorrhage | 2 |
Corpus Luteum, Hyperplasia, Lymphoid | 3 1 |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Endometrium, Hyperplasia, Cystic | 1 2 |
Endometrium, Infarct | |
__________________________________________________________________________|
Vagina | + |
Cyst | 4 |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
Hyperplasia, Focal, Histiocytic | |
Metaplasia, Osseous | 3 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Mediastinal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Focal | 2 3 |
Pigmentation | 3 1 2 1 2 3 2 3 3 2 3 2 2 3 3 1 2 3 2 2 3 2 1 1 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | |
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 2 2 2 3 2 2 2 2 2 2 2 3 2 2 3 1 2 2 2 |
Hyperplasia | 2 2 1 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 0| 3| 4| 2| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 8| 3| 5| 6| 3| 3| 0| 5| 0| 0|
| 1| 9| 1| 7| 4| 1| 2| 1| 1| 1| 1| 4| 1| 1| 1| 7| 1| 7| 6| 1| 1| 0| 3| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 4 3 1 2 1 1 4 |
Inflammation, Chronic, Focal | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 4 3 |
Hemorrhage | 2 3 |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Fibrosis, Focal | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Metaplasia, Focal, Osseous | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 3 |
Fibrosis | |
Hemorrhage | 3 |
Inflammation, Chronic | 3 |
Retina, Degeneration | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Nephropathy | 2 2 1 1 2 3 2 2 2 1 1 2 2 2 2 2 1 2 1 3 1 1 2 1 1|
Cortex, Renal Tubule, Autolysis | |
Glomerulus, Autolysis | |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 3 1 1 2 1 1 1 2 2 1 2 1 1 3 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 2| 6| 5| 3| 9| 3| 3| 7| 3| 7| 6| 3| 3|
| 1| 2| 1| 0| 1| 1| 1| 1| 1| 1| 4| 1| 2| 7| 6| 1| 0| 1| 1| 9| 1| 9| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Eosinophilic Focus | X |
Fatty Change | 2 3 1 3 3 |
Fibrosis, Focal | 2 |
Focal Cellular Change | |
Hepatodiaphragmatic Nodule | 3 3 |
Hyperplasia, Multifocal | 2 2 2 3 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | 2 1 1 2 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X|
Necrosis, Focal | 3 |
Pigmentation | |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 2 1 2 3 2|
Centrilobular, Atrophy | 2 3 2 4 |
Centrilobular, Hemorrhage | 4 |
Centrilobular, Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 3 2 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Atrophy, Diffuse | 3 |
Atrophy, Focal | 1 1 1 2 1 1 2 1 3 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 |
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Erosion | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 2| 6| 5| 3| 9| 3| 3| 7| 3| 7| 6| 3| 3|
| 1| 2| 1| 0| 1| 1| 1| 1| 1| 1| 4| 1| 2| 7| 6| 1| 0| 1| 1| 9| 1| 9| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 |
__________________________________________________________________________|
Tooth | |
Gingiva, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Inflammation, | |
Chronic | |
Mesenteric Artery, Thrombosis | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Embolus | 2 |
Inflammation, Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + M + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | 2|
Congestion | 2 |
Depletion Cellular | 3 |
Focal Cellular Change | 2 2 1 1 2 1 2|
Hyperplasia, Focal | 1 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 2 1 4 2 |
Cyst | 2 2 |
Granuloma | 2 |
Hemorrhage | 3 |
Pars Distalis, Focal Cellular Change | 2 3 1 2 1 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
C-Cell, Hyperplasia | 2 3 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 2| 6| 5| 3| 9| 3| 3| 7| 3| 7| 6| 3| 3|
| 1| 2| 1| 0| 1| 1| 1| 1| 1| 1| 4| 1| 2| 7| 6| 1| 0| 1| 1| 9| 1| 9| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Degeneration, Cystic | 2 2 2 1 2 2 1 1 3 1 2 1 2 1|
Hyperplasia | 2 2 2 2 2 2 1 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hemorrhage | |
Corpus Luteum, Hyperplasia, Lymphoid | |
Corpus Luteum, Thecal Cell, | |
Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Endometrium, Hyperplasia, Cystic | 2 |
Endometrium, Infarct | 3 |
__________________________________________________________________________|
Vagina | + +|
Cyst | 3|
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
Hyperplasia, Focal, Histiocytic | 1 3|
Metaplasia, Osseous | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 |
Necrosis, Focal | |
Pigmentation | 2 3 3 1 3 3 3 3 3 2 3 3 1 1 2 2 1 3 3 3 2 2 2 3 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Fibrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 1 2 3 1 3 3 3 2 2 1 2 2 3 2 2 2 3 2 2 2|
Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 2| 6| 5| 3| 9| 3| 3| 7| 3| 7| 6| 3| 3|
| 1| 2| 1| 0| 1| 1| 1| 1| 1| 1| 4| 1| 2| 7| 6| 1| 0| 1| 1| 9| 1| 9| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 2 1 2 2 1 2 1 |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 4 3 3 3 |
Hemorrhage | 3 3 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Fibrosis, Focal | |
Infiltration Cellular, Mixed Cell | |
Metaplasia, Focal, Osseous | 1 |
Thrombosis | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Fibrosis | |
Hemorrhage | |
Inflammation, Chronic | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Nephropathy | 2 2 2 4 3 3 1 2 3 1 2 1 1 2 2 2 2 2 3 3 2 1 1 3 1|
Cortex, Renal Tubule, Autolysis | 3 |
Glomerulus, Autolysis | 3 |
Renal Tubule, Pigmentation | 2 2 3 2 2 2 2 2 2 2 2 1 3 1 1 2 2 2 2 2 2 2 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0.0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X X X X X X X | 40 |
Clear Cell Focus | | 4 |
Eosinophilic Focus | | 4 |
Fatty Change | | 14 2.3|
Fibrosis, Focal | | 1 2.0|
Focal Cellular Change | | 1 2.0|
Hepatodiaphragmatic Nodule | 2 2 3 | 8 2.4|
Hyperplasia, Multifocal | | 9 2.2|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Focal | 1 1 1 1 1 1 1 | 33 1.1|
Mixed Cell Focus | X | 5 |
Necrosis, Focal | | 2 2.0|
Pigmentation | | 1 2.0|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 2 1 1 1 | 27 1.4|
Centrilobular, Atrophy | | 14 2.5|
Centrilobular, Hemorrhage | | 1 4.0|
Centrilobular, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 11 |
Fat, Necrosis | 1 | 7 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Accessory Spleen | 2 | 1 2.0|
Atrophy, Diffuse | | 2 3.0|
Atrophy, Focal | 1 1 1 1 2 | 21 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hemorrhage, Focal | | 1 1.0|
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0.0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Bacterium | | 1 2.0|
Erosion | | 2 1.5|
Inflammation, Chronic | | 1 1.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Gingiva, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 4.0|
Mesenteric Artery, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Bacterium | | 1 2.0|
Embolus | | 1 2.0|
Inflammation, Chronic, Focal | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Accessory Adrenal Cortical Nodule | 1 | 2 1.0|
Angiectasis | | 1 2.0|
Congestion | | 4 2.3|
Depletion Cellular | | 1 3.0|
Focal Cellular Change | | 13 1.6|
Hyperplasia, Focal | | 1 1.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | 2 1 2 2 3 2 2 | 19 2.2|
Cyst | 2 | 4 1.8|
Granuloma | | 1 2.0|
Hemorrhage | | 1 3.0|
Pars Distalis, Focal Cellular Change | | 6 1.8|
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 | 16 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0.0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | | 1 1.0|
C-Cell, Hyperplasia | | 10 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Cyst | | 1 2.0|
Degeneration, Cystic | 1 1 1 1 1 1 1 1 | 42 1.4|
Hyperplasia | | 10 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | | 5 2.6|
Hemorrhage | | 1 2.0|
Corpus Luteum, Hyperplasia, Lymphoid | | 2 2.0|
Corpus Luteum, Thecal Cell, | | |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | | 1 2.0|
Endometrium, Hyperplasia, Cystic | | 3 1.7|
Endometrium, Infarct | 3 | 2 3.0|
__________________________________________________________________________|____________|
Vagina | | 3 |
Cyst | | 2 3.5|
Mucosa, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 2 2.0|
Hyperplasia, Focal, Histiocytic | 1 | 3 1.7|
Metaplasia, Osseous | | 1 3.0|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 14 |
Mediastinal, Congestion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0.0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 2 1.5|
Necrosis, Focal | | 2 2.5|
Pigmentation | 2 2 2 2 2 2 2 2 2 2 | 60 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
Cyst | | 1 2.0|
Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 2 | 44 2.1|
Hyperplasia | | 9 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 3 | 18 1.9|
Inflammation, Chronic, Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 8 3.3|
Hemorrhage | | 4 2.8|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Bacterium | | 1 2.0|
Fibrosis, Focal | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Metaplasia, Focal, Osseous | | 1 1.0|
Thrombosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0.0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Cataract | 2 | 3 2.7|
Fibrosis | 3 | 1 3.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Retina, Degeneration | 3 | 3 3.7|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Bacterium | | 1 2.0|
Nephropathy | 1 2 2 1 1 2 1 1 2 1 | 60 1.8|
Cortex, Renal Tubule, Autolysis | | 1 3.0|
Glomerulus, Autolysis | | 1 3.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 2 1 1 1 1 | 60 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 6| 7| 6| 4| 7|
DAY ON TEST | 7| 1| 4| 3| 3| 3| 3| 3| 3| 7| 0| 0| 2| 3| 3| 3| 7| 3| 4| 6| 7| 0| 9| 8| 3|
| 4| 0| 1| 1| 1| 1| 1| 1| 1| 6| 8| 2| 8| 1| 1| 1| 0| 1| 8| 5| 4| 2| 5| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Parasite Metazoan | 2 1 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + A + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X|
Eosinophilic Focus | X |
Fatty Change | 3 3 1 1 3 2 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 3 1|
Hepatodiaphragmatic Nodule, Multiple | 2 3 |
Hyperplasia, Multifocal | 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 1 1 1 2 1 1 2 2 1 1 2 1 1|
Mixed Cell Focus | X X X X X|
Necrosis, Focal | 1 |
Bile Duct, Dilatation | 4 |
Bile Duct, Hyperplasia | 1 1 1 1 2 2 2 |
Centrilobular, Atrophy | 3 2 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Accessory Spleen | 1 |
Inflammation, Chronic | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Atrophy, Diffuse | 3 |
Atrophy, Focal | 1 2 1 1 2|
Inflammation, Chronic | |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Chronic | 2 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 6| 7| 6| 4| 7|
DAY ON TEST | 7| 1| 4| 3| 3| 3| 3| 3| 3| 7| 0| 0| 2| 3| 3| 3| 7| 3| 4| 6| 7| 0| 9| 8| 3|
| 4| 0| 1| 1| 1| 1| 1| 1| 1| 6| 8| 2| 8| 1| 1| 1| 0| 1| 8| 5| 4| 2| 5| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Congestion | |
Focal Cellular Change | 1 2 2 1 2|
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 2 3 2 |
Cyst | 2 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Focal Cellular Change | 2 2 2 |
Pars Distalis, Hyperplasia, Focal | 3 4 2 2 2 |
Rathke's Cleft, Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Focal | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 |
Follicle, Dilatation | 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | |
Degeneration, Cystic | 2 1 1 1 1 1 1 2 1 3 2 2 2 2 1 1 1 2 2 2 2 2|
Hyperplasia | 2 1 1 3 |
Inflammation, Chronic | 2 |
Duct, Hyperplasia, Squamous | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 2 |
Corpus Luteum, Hyperplasia, Lymphoid | 2 |
Corpus Luteum, Thecal Cell, | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 6| 7| 6| 4| 7|
DAY ON TEST | 7| 1| 4| 3| 3| 3| 3| 3| 3| 7| 0| 0| 2| 3| 3| 3| 7| 3| 4| 6| 7| 0| 9| 8| 3|
| 4| 0| 1| 1| 1| 1| 1| 1| 1| 6| 8| 2| 8| 1| 1| 1| 0| 1| 8| 5| 4| 2| 5| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 1 |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 2 1 2 2 |
__________________________________________________________________________|
Vagina | |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
Hyperplasia, Focal, Histiocytic | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Depletion Lymphoid | |
Mediastinal, Congestion | |
Mediastinal, Depletion Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Congestion | 2 |
Pancreatic, Depletion Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 |
Hematopoietic Cell Proliferation | 4 3 2 4 2 |
Pigmentation | 2 3 1 3 3 3 2 3 2 3 1 2 3 2 3 3 2 3 2 3 2 3 3 2 2|
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 2 2 2 3 2 2 3 3 3 2 2 2 3 3 2 |
Hyperplasia | 2 2 2 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 6| 7| 6| 4| 7|
DAY ON TEST | 7| 1| 4| 3| 3| 3| 3| 3| 3| 7| 0| 0| 2| 3| 3| 3| 7| 3| 4| 6| 7| 0| 9| 8| 3|
| 4| 0| 1| 1| 1| 1| 1| 1| 1| 6| 8| 2| 8| 1| 1| 1| 0| 1| 8| 5| 4| 2| 5| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 1 3 3 1 2 4 2 |
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Mixed Cell | |
Alveolar Epithelium, Hyperplasia | 1 2 |
Mediastinum, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 |
Nasolacrimal Duct, Cyst | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Hemorrhage | 3 |
Inflammation, Chronic | 4 |
Necrosis, Focal | 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Nephropathy | 1 1 2 1 2 2 2 2 1 1 1 2 1 2 2 2 2 1 2 1 1 1 1 1 1|
Renal Tubule, Hyperplasia, Oncocytic | |
Renal Tubule, Pigmentation | 2 1 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 7| 5| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 6|
DAY ON TEST | 6| 9| 3| 3| 3| 9| 0| 2| 3| 5| 3| 3| 7| 3| 3| 3| 3| 3| 5| 9| 3| 9| 9| 3| 9|
| 6| 6| 1| 1| 1| 6| 0| 1| 1| 0| 1| 1| 4| 1| 1| 2| 1| 1| 1| 6| 1| 6| 6| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X |
Fatty Change | 2 2 3 1 3 3 2|
Focal Cellular Change | 2|
Hematopoietic Cell Proliferation | 2 1 |
Hepatodiaphragmatic Nodule | 2 2 2|
Hepatodiaphragmatic Nodule, Multiple | |
Hyperplasia, Multifocal | 2 2 3 2 2 2 2|
Infiltration Cellular, Mixed Cell | 2 1 2 |
Inflammation, Focal | 2 1 1 2 2 1 2 1 2 1 1 |
Mixed Cell Focus | X X X |
Necrosis, Focal | |
Bile Duct, Dilatation | |
Bile Duct, Hyperplasia | 1 3 1 2 1 1 1 2 2 3 1 3 |
Centrilobular, Atrophy | 4 2 2 3 2 4 3 2|
__________________________________________________________________________|
Mesentery | + + + +|
Accessory Spleen | |
Inflammation, Chronic | 3 |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Atrophy, Diffuse | |
Atrophy, Focal | 2 1 2 2 1 2 4 1 1 |
Inflammation, Chronic | 3 |
Duct, Dilatation | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 7| 5| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 6|
DAY ON TEST | 6| 9| 3| 3| 3| 9| 0| 2| 3| 5| 3| 3| 7| 3| 3| 3| 3| 3| 5| 9| 3| 9| 9| 3| 9|
| 6| 6| 1| 1| 1| 6| 0| 1| 1| 0| 1| 1| 4| 1| 1| 2| 1| 1| 1| 6| 1| 6| 6| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 1 |
Focal Cellular Change | 2 2 2 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 1 3|
Cyst | 3 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Focal Cellular Change | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 |
Rathke's Cleft, Hyperplasia, Cystic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 1 |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 1 1 1 |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Atrophy | |
Cyst | 1 |
Degeneration, Cystic | 2 2 2 1 2 2 2 1 1 1 2 1 1 1 2 2|
Hyperplasia | 2 2 |
Inflammation, Chronic | |
Duct, Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 2 |
Corpus Luteum, Hyperplasia, Lymphoid | |
Corpus Luteum, Thecal Cell, | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 7| 5| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 6|
DAY ON TEST | 6| 9| 3| 3| 3| 9| 0| 2| 3| 5| 3| 3| 7| 3| 3| 3| 3| 3| 5| 9| 3| 9| 9| 3| 9|
| 6| 6| 1| 1| 1| 6| 0| 1| 1| 0| 1| 1| 4| 1| 1| 2| 1| 1| 1| 6| 1| 6| 6| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 1 |
Endometrium, Cyst | 2|
Endometrium, Hyperplasia, Cystic | 1 1 1 1 1 |
__________________________________________________________________________|
Vagina | + |
Cyst | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 4 2 |
Hyperplasia, Focal, Histiocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + +|
Inguinal, Depletion Lymphoid | 4 |
Mediastinal, Congestion | 2 |
Mediastinal, Depletion Lymphoid | 4 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Pancreatic, Congestion | |
Pancreatic, Depletion Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 4 |
Hyperplasia, Lymphoid | |
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 4 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 2 2|
Hematopoietic Cell Proliferation | 2 2 3 2 3 2 2 3 2 |
Pigmentation | 2 2 3 2 3 3 1 2 3 1 3 3 3 2 1 1 3 2 1 1 3 3 3 3 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 2 2 2 1 4 2 1 1 3 3 3 3 2 2 2|
Hyperplasia | 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 7| 5| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 6|
DAY ON TEST | 6| 9| 3| 3| 3| 9| 0| 2| 3| 5| 3| 3| 7| 3| 3| 3| 3| 3| 5| 9| 3| 9| 9| 3| 9|
| 6| 6| 1| 1| 1| 6| 0| 1| 1| 0| 1| 1| 4| 1| 1| 2| 1| 1| 1| 6| 1| 6| 6| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 3 2 3 3 3 3 |
Hemorrhage | 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Mixed Cell | 3 |
Alveolar Epithelium, Hyperplasia | 1 |
Mediastinum, Infiltration Cellular, | |
Lymphocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Nasolacrimal Duct, Cyst | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Hemorrhage | |
Inflammation, Chronic | |
Necrosis, Focal | |
Retina, Degeneration | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Nephropathy | 2 1 2 1 2 2 2 2 2 2 2 1 2 2 1 1 2 1 2 2 2 2 2 1|
Renal Tubule, Hyperplasia, Oncocytic | 1 |
Renal Tubule, Pigmentation | 2 2 2 2 2 3 2 2 2 1 2 3 2 2 2 2 2 2 3 2 2 2 2 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.125% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
Parasite Metazoan | 1 | 7 1.6|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 2 3.0|
Basophilic Focus | X X X X X | 43 |
Clear Cell Focus | X | 7 |
Eosinophilic Focus | | 4 |
Fatty Change | 2 | 14 2.2|
Focal Cellular Change | | 1 2.0|
Hematopoietic Cell Proliferation | | 2 1.5|
Hepatodiaphragmatic Nodule | 3 | 6 2.2|
Hepatodiaphragmatic Nodule, Multiple | | 2 2.5|
Hyperplasia, Multifocal | | 10 2.1|
Infiltration Cellular, Mixed Cell | | 4 1.8|
Inflammation, Focal | 1 1 1 1 1 1 1 1 1 | 33 1.3|
Mixed Cell Focus | | 8 |
Necrosis, Focal | | 1 1.0|
Bile Duct, Dilatation | | 1 4.0|
Bile Duct, Hyperplasia | 2 1 3 1 1 1 | 25 1.6|
Centrilobular, Atrophy | | 11 2.7|
__________________________________________________________________________|____________|
Mesentery | + | 9 |
Accessory Spleen | | 1 1.0|
Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | 2 | 4 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Accessory Spleen | 2 | 1 2.0|
Atrophy, Diffuse | | 1 3.0|
Atrophy, Focal | 2 1 2 1 | 18 1.6|
Inflammation, Chronic | | 1 3.0|
Duct, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.125% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.0|
Congestion | | 1 1.0|
Focal Cellular Change | | 9 1.8|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | 1 2 | 13 2.1|
Cyst | 3 2 | 6 2.3|
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Focal Cellular Change | | 4 2.0|
Pars Distalis, Hyperplasia, Focal | 2 2 | 11 2.3|
Rathke's Cleft, Hyperplasia, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Inflammation, Focal | | 1 1.0|
Ultimobranchial Cyst | 1 2 | 2 1.5|
C-Cell, Hyperplasia | | 8 1.0|
Follicle, Dilatation | | 1 2.0|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.125% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | | 1 4.0|
Cyst | | 1 1.0|
Degeneration, Cystic | 1 1 1 1 1 | 43 1.5|
Hyperplasia | | 6 1.8|
Inflammation, Chronic | | 1 2.0|
Duct, Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | 2 2 3 4 | 10 2.6|
Corpus Luteum, Hyperplasia, Lymphoid | | 1 2.0|
Corpus Luteum, Thecal Cell, | | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | 2 2 | 6 1.7|
Endometrium, Cyst | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 | 10 1.4|
__________________________________________________________________________|____________|
Vagina | + | 2 |
Cyst | 3 | 3 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 4 3.0|
Hyperplasia, Focal, Histiocytic | 1 2 | 4 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 14 |
Inguinal, Depletion Lymphoid | | 1 4.0|
Mediastinal, Congestion | 2 2 | 3 2.0|
Mediastinal, Depletion Lymphoid | | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Congestion | 2 | 2 2.0|
Pancreatic, Depletion Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Congestion | 2 | 1 2.0|
Depletion Lymphoid | | 1 4.0|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Depletion Lymphoid | | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.125% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | | 6 2.0|
Hematopoietic Cell Proliferation | | 14 2.6|
Pigmentation | 2 2 2 2 2 1 2 2 2 2 | 60 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 1 2 | 40 2.2|
Hyperplasia | 1 | 15 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 1 3.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 3 3 | 11 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 16 2.6|
Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 4 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 3 1.3|
Mediastinum, Infiltration Cellular, | | |
Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 4 1.8|
Nasolacrimal Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.125% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cataract | | 1 3.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 4.0|
Necrosis, Focal | | 1 3.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 | 59 1.5|
Renal Tubule, Hyperplasia, Oncocytic | | 1 1.0|
Renal Tubule, Pigmentation | 2 2 3 2 2 3 2 2 2 2 | 60 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 7| 6| 6| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 0| 0| 0| 7| 3| 9| 6| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 9| 5| 3| 9| 3| 3| 4|
| 0| 4| 8| 2| 9| 0| 5| 8| 1| 8| 0| 0| 0| 0| 4| 0| 0| 0| 6| 3| 0| 4| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Fatty Change | 1 2 2|
Fibrosis, Focal | 1 1 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | 3 2 |
Hepatodiaphragmatic Nodule, Multiple | |
Hyperplasia, Multifocal | 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Focal | 2 2 2 2 1 2 1 2 2 1 2 1 1 1 1 1 2 1 2|
Mixed Cell Focus | X X|
Bile Duct, Hyperplasia | 1 1 3 1 1 1 2 |
Centrilobular, Atrophy | 2 2 1|
Centrilobular, Congestion | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Cyst | |
Inflammation, Chronic | 1 |
Fat, Necrosis | 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | |
Atrophy, Focal | 2 1 2 2 2 2 1 2 3 2|
Inflammation, Chronic | 2 |
Acinar Cell, Depletion Secretory | 3|
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3|
Ulcer | 3|
Mucosa, Hyperplasia | 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 7| 6| 6| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 0| 0| 0| 7| 3| 9| 6| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 9| 5| 3| 9| 3| 3| 4|
| 0| 4| 8| 2| 9| 0| 5| 8| 1| 8| 0| 0| 0| 0| 4| 0| 0| 0| 6| 3| 0| 4| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Degeneration, Cystic | 4 |
Focal Cellular Change | 2 2 2 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 1 3 2 2 |
Cyst | |
Pars Distalis, Focal Cellular Change | 1 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst | 2 |
Degeneration, Cystic | 2 1 2 1 1 2 1 1 2 1 2 1 1 2 2 1 1 1|
Hyperplasia | 2 2 2 2|
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Cyst | 2 |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Endometrium, Cyst | 2 |
Endometrium, Hyperplasia, Cystic | 1 2 |
__________________________________________________________________________|
Vagina | + + |
Cyst | 3 |
Cyst, Multiple | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 7| 6| 6| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 0| 0| 0| 7| 3| 9| 6| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 9| 5| 3| 9| 3| 3| 4|
| 0| 4| 8| 2| 9| 0| 5| 8| 1| 8| 0| 0| 0| 0| 4| 0| 0| 0| 6| 3| 0| 4| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
Hyperplasia, Focal, Histiocytic | 3 4 |
__________________________________________________________________________|
Lymph Node | + + + + |
Deep Cervical, Angiectasis | |
Mediastinal, Angiectasis | |
Mediastinal, Congestion | 2 2 |
Mediastinal, Hyperplasia, Macrophage | 3 |
Mediastinal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 |
Necrosis, Focal | |
Pigmentation | 3 1 3 3 2 3 3 1 2 2 3 3 2 3 3 3 3 2 2 3 3 2 2 3 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 2 2 3 2 2 2 3 2 2 2 3 2 2 2 2 2 2|
Hyperplasia | 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hemorrhage, Focal | 2|
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | |
Hyperostosis | 3 3 1 1 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 1 3 2 3 4|
Demyelination, Focal | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 3| 7| 6| 6| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 0| 0| 0| 7| 3| 9| 6| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 9| 5| 3| 9| 3| 3| 4|
| 0| 4| 8| 2| 9| 0| 5| 8| 1| 8| 0| 0| 0| 0| 4| 0| 0| 0| 6| 3| 0| 4| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage, Focal | 2 |
Hyperplasia, Focal, Macrophage | |
Infiltration Cellular, Mixed Cell | 2 |
Alveolar Epithelium, Hyperplasia | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
Cataract | |
Hemorrhage | |
Inflammation, Chronic | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 |
Cyst | |
Fibrosis, Focal | 3 |
Nephropathy | 1 1 2 2 1 1 2 1 1 1 1 2 2 2 1 2 2 1 2 1 1 1 1 1 1|
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | 3 2 2 3 2 2 3 3 2 3 3 2 3 2 3 2 3 3 2 3 2 2 2 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 4| 6| 5| 6| 7| 7| 7| 4| 7| 3| 4| 7| 7| 7| 6| 7| 5| 4| 6| 7| 5| 7| 7| 6|
DAY ON TEST | 9| 9| 4| 5| 8| 3| 3| 0| 9| 3| 7| 6| 3| 3| 0| 4| 3| 1| 3| 5| 3| 3| 3| 3| 6|
| 5| 9| 7| 3| 5| 0| 0| 2| 2| 0| 9| 1| 0| 0| 9| 7| 0| 8| 4| 0| 0| 8| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Fatty Change | 1 2 1 1 |
Fibrosis, Focal | |
Focal Cellular Change | 1 2 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 2 2 3 2 2 3 3 2 3|
Hepatodiaphragmatic Nodule, Multiple | 3 3 |
Hyperplasia, Multifocal | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 2 1 1 1 1 2 2 1 1 1 1 1 1 2 2 1 1 2 |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 2 2 1 1 2 1 1 2 2 2 1 |
Centrilobular, Atrophy | 2 |
Centrilobular, Congestion | 2 |
Centrilobular, Necrosis | 2|
__________________________________________________________________________|
Mesentery | + + + + + + |
Cyst | 3 |
Inflammation, Chronic | |
Fat, Necrosis | 1 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Atrophy, Diffuse | 2 |
Atrophy, Focal | 2 1 1 1 1 1 1 1 2 |
Inflammation, Chronic | |
Acinar Cell, Depletion Secretory | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 |
Ulcer | 2 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 4| 6| 5| 6| 7| 7| 7| 4| 7| 3| 4| 7| 7| 7| 6| 7| 5| 4| 6| 7| 5| 7| 7| 6|
DAY ON TEST | 9| 9| 4| 5| 8| 3| 3| 0| 9| 3| 7| 6| 3| 3| 0| 4| 3| 1| 3| 5| 3| 3| 3| 3| 6|
| 5| 9| 7| 3| 5| 0| 0| 2| 2| 0| 9| 1| 0| 0| 9| 7| 0| 8| 4| 0| 0| 8| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Cystic | 3 |
Focal Cellular Change | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 1 3 |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 2 3 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 2 2 2 1 2 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration, Cystic | 1 1 1 2 2 1 2 1 2 1 2 2 2 2 1 2 2 1 1 3 2|
Hyperplasia | 2 3 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | 3 |
Cyst | 4 1 3 1 3 |
Bilateral, Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 1 1 |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 2 2 |
__________________________________________________________________________|
Vagina | + |
Cyst | |
Cyst, Multiple | 3 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 4| 6| 5| 6| 7| 7| 7| 4| 7| 3| 4| 7| 7| 7| 6| 7| 5| 4| 6| 7| 5| 7| 7| 6|
DAY ON TEST | 9| 9| 4| 5| 8| 3| 3| 0| 9| 3| 7| 6| 3| 3| 0| 4| 3| 1| 3| 5| 3| 3| 3| 3| 6|
| 5| 9| 7| 3| 5| 0| 0| 2| 2| 0| 9| 1| 0| 0| 9| 7| 0| 8| 4| 0| 0| 8| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
Hyperplasia, Focal, Histiocytic | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + +|
Deep Cervical, Angiectasis | 4 |
Mediastinal, Angiectasis | 3 |
Mediastinal, Congestion | 3 3 2|
Mediastinal, Hyperplasia, Macrophage | |
Mediastinal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 4 3 3 3|
Necrosis, Focal | 4 |
Pigmentation | 3 1 3 3 1 3 2 3 1 3 3 3 2 3 2 2 3 2 3 3 3 3 3 3 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 3|
Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 1 |
Hemorrhage, Focal | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | 2 |
Hyperostosis | 2 2 1 2 2|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 3 3 2 |
Demyelination, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 4| 6| 5| 6| 7| 7| 7| 4| 7| 3| 4| 7| 7| 7| 6| 7| 5| 4| 6| 7| 5| 7| 7| 6|
DAY ON TEST | 9| 9| 4| 5| 8| 3| 3| 0| 9| 3| 7| 6| 3| 3| 0| 4| 3| 1| 3| 5| 3| 3| 3| 3| 6|
| 5| 9| 7| 3| 5| 0| 0| 2| 2| 0| 9| 1| 0| 0| 9| 7| 0| 8| 4| 0| 0| 8| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage, Focal | 1 |
Hyperplasia, Focal, Macrophage | 2 |
Infiltration Cellular, Mixed Cell | |
Alveolar Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Atrophy | 2 |
Cataract | 3 2 |
Hemorrhage | 3 |
Inflammation, Chronic | 3 |
Retina, Degeneration | 3 3 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Cyst | 1 |
Fibrosis, Focal | |
Nephropathy | 1 1 1 1 1 1 1 1 2 1 2 1 1 1 2 1 2 2 1 1 1 1 1 1 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 3 2 3 2 2 1 2 3 3 2 3 2 3 3 2 2 2 2 2 1 3 3 2 3 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X X X | 50 |
Clear Cell Focus | | 7 |
Fatty Change | | 7 1.4|
Fibrosis, Focal | | 2 1.0|
Focal Cellular Change | | 2 1.5|
Hematopoietic Cell Proliferation | | 2 1.5|
Hepatodiaphragmatic Nodule | 2 | 12 2.4|
Hepatodiaphragmatic Nodule, Multiple | | 2 3.0|
Hyperplasia, Multifocal | | 3 2.0|
Infiltration Cellular, Mixed Cell | | 3 2.0|
Inflammation, Focal | 1 1 1 1 | 41 1.4|
Mixed Cell Focus | X | 4 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 | 24 1.4|
Centrilobular, Atrophy | | 4 1.8|
Centrilobular, Congestion | | 1 2.0|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 10 |
Cyst | | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Fat, Necrosis | 2 | 7 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy, Diffuse | | 1 2.0|
Atrophy, Focal | 1 1 | 21 1.5|
Inflammation, Chronic | | 1 2.0|
Acinar Cell, Depletion Secretory | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 2 2.5|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Artery, Inflammation, Chronic | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Degeneration, Cystic | | 2 3.5|
Focal Cellular Change | 1 2 | 10 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + | 59 |
Angiectasis | 2 2 2 2 1 | 12 2.1|
Cyst | | 2 2.0|
Pars Distalis, Focal Cellular Change | | 2 1.5|
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 | 14 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | 2 | 3 1.7|
C-Cell, Hyperplasia | | 11 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Cyst | | 1 2.0|
Degeneration, Cystic | 1 1 1 1 1 1 1 2 | 47 1.4|
Hyperplasia | | 6 2.2|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | | 1 3.0|
Cyst | 2 1 2 2 | 10 2.1|
Bilateral, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | 1 1 | 5 1.2|
Endometrium, Cyst | | 1 2.0|
Endometrium, Hyperplasia, Cystic | | 4 1.8|
__________________________________________________________________________|____________|
Vagina | | 3 |
Cyst | | 1 3.0|
Cyst, Multiple | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 2 2.5|
Hyperplasia, Focal, Histiocytic | | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 11 |
Deep Cervical, Angiectasis | | 1 4.0|
Mediastinal, Angiectasis | | 1 3.0|
Mediastinal, Congestion | 1 2 | 7 2.1|
Mediastinal, Hyperplasia, Macrophage | | 1 3.0|
Mediastinal, Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Congestion | | 2 2.0|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | 9 3.3|
Necrosis, Focal | | 1 4.0|
Pigmentation | 3 2 2 2 3 2 2 3 2 2 | 60 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 60 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 3 2 1 | 42 2.1|
Hyperplasia | 1 1 2 | 13 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Cyst Epithelial Inclusion | | 1 1.0|
Hemorrhage, Focal | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fracture Healed | | 1 2.0|
Hyperostosis | | 9 1.9|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 1 | 11 2.6|
Demyelination, Focal | | 1 1.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
Hemorrhage, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 2.0|
Hemorrhage, Focal | | 2 1.5|
Hyperplasia, Focal, Macrophage | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 5 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Atrophy | | 1 2.0|
Cataract | | 2 2.5|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Retina, Degeneration | | 2 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Atrophy, Focal | | 1 3.0|
Cyst | | 1 1.0|
Fibrosis, Focal | | 1 3.0|
Nephropathy | 1 1 1 1 1 1 2 1 1 | 58 1.3|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Pigmentation | 3 3 3 3 3 3 3 3 2 3 | 60 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 7| 7| 0| 3| 4| 1| 5| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 1| 3| 0| 3| 3|
| 8| 0| 0| 4| 4| 2| 0| 1| 8| 6| 0| 0| 8| 0| 0| 0| 0| 0| 1| 0| 1| 0| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X |
Eosinophilic Focus | |
Fatty Change | 1 1 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | 1 3 2 2 |
Hepatodiaphragmatic Nodule, Multiple | |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Multifocal | |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | 1 2 2 1 1 2 2 2 1 2 2 1 1 1 1 1 1 1 2|
Mixed Cell Focus | X X X X X |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 2 2 2 1|
Centrilobular, Atrophy | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Accessory Spleen | |
Inflammation, Chronic | |
Fat, Necrosis | 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + M + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | |
Atrophy, Focal | 1 2 1 1 2 1 |
Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Mucosa, Hyperplasia | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
Hypertrophy, Squamous | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 7| 7| 0| 3| 4| 1| 5| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 1| 3| 0| 3| 3|
| 8| 0| 0| 4| 4| 2| 0| 1| 8| 6| 0| 0| 8| 0| 0| 0| 0| 0| 1| 0| 1| 0| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mesenteric Artery, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Congestion | |
Focal Cellular Change | 2 2 1 1 2 |
Capsule, Extra Adrenal Tissue, | |
Fibrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 2 2 |
Cyst | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Focal Cellular Change | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 2 2 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 1|
Degeneration, Cystic | 2 1 2 2 1 3 3 1 2 2 2 2 2 1 1 2 2 1 1 |
Hyperplasia | 2 2 2 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 1 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hydrometra | 3 1 |
Endometrium, Cyst | 2 |
Endometrium, Hyperplasia, Cystic | 1 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 7| 7| 0| 3| 4| 1| 5| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 1| 3| 0| 3| 3|
| 8| 0| 0| 4| 4| 2| 0| 1| 8| 6| 0| 0| 8| 0| 0| 0| 0| 0| 1| 0| 1| 0| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Focal, Histiocytic | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Hyperplasia | |
Mediastinal, Congestion | 2 |
Mediastinal, Hyperplasia | 2 |
Mediastinal, Pigmentation | |
Pancreatic, Edema | 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Pancreatic, Inflammation, Chronic | |
Pancreatic, Pigmentation | |
Renal, Hyperplasia, Macrophage | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 1 2 |
Hyperplasia | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | |
Hematopoietic Cell Proliferation | 4 |
Pigmentation | 3 3 3 3 3 3 3 3 3 4 3 3 3 3 3 4 3 1 3 3 3 4 3 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 1|
Hyperplasia | 2 2 1 2 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 3 1 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 4 2 1 3 3 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 7| 7| 0| 3| 4| 1| 5| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 1| 3| 0| 3| 3|
| 8| 0| 0| 4| 4| 2| 0| 1| 8| 6| 0| 0| 8| 0| 0| 0| 0| 0| 1| 0| 1| 0| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperplasia, Focal, Macrophage | 2 |
Alveolar Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + M + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1|
Interstitium, Infarct | |
Papilla, Epithelium, Hyperplasia, | |
Focal | 1 |
Renal Tubule, Hyperplasia, Oncocytic | 1 1 |
Renal Tubule, Pigmentation | 3 3 3 3 3 3 3 3 2 3 3 3 3 2 3 3 3 3 3 2 3 3 3 3 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 4| 7| 5| 7| 6| 5| 7| 6| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 8| 0| 6| 3| 0| 2| 3| 2| 9| 0| 9| 3| 1| 1| 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3|
| 3| 0| 5| 0| 2| 8| 0| 2| 5| 9| 3| 0| 8| 4| 4| 0| 5| 2| 0| 0| 2| 7| 7| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X |
Eosinophilic Focus | X |
Fatty Change | 1 1 1 2 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 2 2 2 2 2 2 2 3 |
Hepatodiaphragmatic Nodule, Multiple | 3 3 2 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
Hyperplasia, Multifocal | 2 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 1 2 2 1 2 1 2 1 1 1 2 2 1 1 2 2 2 1 1 2 2 1|
Mixed Cell Focus | X X |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1|
Centrilobular, Atrophy | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Accessory Spleen | 1 |
Inflammation, Chronic | 2 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 3 |
Atrophy, Focal | 2 1 1 2 2 |
Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
Hypertrophy, Squamous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 4| 7| 5| 7| 6| 5| 7| 6| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 8| 0| 6| 3| 0| 2| 3| 2| 9| 0| 9| 3| 1| 1| 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3|
| 3| 0| 5| 0| 2| 8| 0| 2| 5| 9| 3| 0| 8| 4| 4| 0| 5| 2| 0| 0| 2| 7| 7| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 |
Congestion | 2 2 |
Focal Cellular Change | 1 1 3 1 2 2 1 1|
Capsule, Extra Adrenal Tissue, | |
Fibrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2|
Cyst | 2 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Focal Cellular Change | 2 |
Pars Distalis, Hyperplasia, Focal | 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration, Cystic | 2 1 1 1 2 2 1 2 2 1 1 1 1 2 2 1|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 2 4 1 1 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 4| 7| 5| 7| 6| 5| 7| 6| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 8| 0| 6| 3| 0| 2| 3| 2| 9| 0| 9| 3| 1| 1| 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3|
| 3| 0| 5| 0| 2| 8| 0| 2| 5| 9| 3| 0| 8| 4| 4| 0| 5| 2| 0| 0| 2| 7| 7| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Focal, Histiocytic | 1 3 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Inguinal, Hyperplasia | 2 3 |
Mediastinal, Congestion | |
Mediastinal, Hyperplasia | 2 3 |
Mediastinal, Pigmentation | 2 |
Pancreatic, Edema | |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Inflammation, Chronic | 3 |
Pancreatic, Pigmentation | |
Renal, Hyperplasia, Macrophage | 3 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia | |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 4 4 3 3 3 3 |
Pigmentation | 3 3 3 3 3 2 3 3 3 3 2 3 1 3 1 3 1 3 3 3 3 3 3 2 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 3 2 1 1 2 2 2 2 2 2 2 2 3 2 2 2|
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 1 1 2 3|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 4 4 2 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 4| 7| 5| 7| 6| 5| 7| 6| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 8| 0| 6| 3| 0| 2| 3| 2| 9| 0| 9| 3| 1| 1| 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3|
| 3| 0| 5| 0| 2| 8| 0| 2| 5| 9| 3| 0| 8| 4| 4| 0| 5| 2| 0| 0| 2| 7| 7| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperplasia, Focal, Macrophage | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Nephropathy | 1 1 1 1 1 1 1 2 2 1 2 1 1 2 1 1 1 1 1 2 1 1 1 1|
Interstitium, Infarct | 4 |
Papilla, Epithelium, Hyperplasia, | |
Focal | |
Renal Tubule, Hyperplasia, Oncocytic | 1 2 1|
Renal Tubule, Pigmentation | 2 3 2 2 3 3 3 3 3 3 3 3 1 2 3 2 3 2 3 2 2 3 3 3 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + | 58 |
Parasite Metazoan | 1 | 4 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.0|
Basophilic Focus | X X X X X X X X | 55 |
Clear Cell Focus | | 12 |
Eosinophilic Focus | | 1 |
Fatty Change | | 7 1.1|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | 3 3 2 2 | 16 2.2|
Hepatodiaphragmatic Nodule, Multiple | | 3 2.7|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Multifocal | | 2 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Focal | 1 1 1 2 | 45 1.4|
Mixed Cell Focus | | 7 |
Necrosis, Focal | | 1 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 | 33 1.1|
Centrilobular, Atrophy | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Accessory Spleen | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy, Diffuse | | 1 3.0|
Atrophy, Focal | 1 1 | 13 1.4|
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 1.0|
Mucosa, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | | 1 |
Hypertrophy, Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 3 1.0|
Congestion | | 2 2.0|
Focal Cellular Change | | 13 1.5|
Capsule, Extra Adrenal Tissue, | | |
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Angiectasis | 2 2 1 | 11 1.9|
Cyst | 3 2 | 4 2.3|
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Focal Cellular Change | 1 | 3 1.7|
Pars Distalis, Hyperplasia, Focal | 2 | 9 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 1 2 1 | 14 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Cyst | | 2 2.0|
Degeneration, Cystic | 1 1 1 2 | 39 1.6|
Hyperplasia | | 7 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Angiectasis | | 1 2.0|
Cyst | 3 | 9 2.2|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Hydrometra | 2 | 3 2.0|
Endometrium, Cyst | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 1 1 | 6 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 3 3.0|
Hyperplasia, Focal, Histiocytic | | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 10 |
Inguinal, Hyperplasia | | 2 2.5|
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Hyperplasia | | 3 2.3|
Mediastinal, Pigmentation | 3 | 2 2.5|
Pancreatic, Edema | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Inflammation, Chronic | | 1 3.0|
Pancreatic, Pigmentation | 2 | 1 2.0|
Renal, Hyperplasia, Macrophage | | 1 3.0|
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Congestion | | 4 1.8|
Hyperplasia | | 1 2.0|
Pigmentation | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Cyst | 3 | 1 3.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 8 3.4|
Pigmentation | 3 3 3 3 3 3 3 3 3 3 | 59 2.9|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 2 3 | 37 2.0|
Hyperplasia | 1 | 16 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 9 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 14 2.9|
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Fibrosis, Focal | | 1 1.0|
Hyperplasia, Focal, Macrophage | | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Fungus | | 1 2.0|
Inflammation, Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 3.0|
Retina, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 2.0|
Nephropathy | 1 2 1 2 1 2 1 1 1 | 58 1.2|
Interstitium, Infarct | | 1 4.0|
Papilla, Epithelium, Hyperplasia, | | |
Focal | | 1 1.0|
Renal Tubule, Hyperplasia, Oncocytic | | 5 1.2|
Renal Tubule, Pigmentation | 3 3 3 3 2 3 3 3 3 3 | 60 2.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 6| 5| 4| 7| 3| 7| 2| 5| 5| 7| 5| 5| 6| 3| 6| 6| 7| 7| 4| 5|
DAY ON TEST | 3| 7| 3| 3| 8| 1| 5| 1| 1| 9| 3| 9| 0| 8| 3| 6| 4| 7| 8| 8| 6| 2| 0| 3| 5|
| 0| 3| 5| 0| 9| 7| 6| 9| 0| 2| 0| 9| 3| 4| 0| 1| 1| 4| 1| 0| 8| 9| 2| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + M + + + + + + + +|
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Liver | + + A + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Atrophy, Focal | |
Basophilic Focus | X X X X X |
Clear Cell Focus | X X |
Congestion, Focal | 2 |
Degeneration, Cystic | 1 2 1 2 2 |
Eosinophilic Focus | X X X |
Fatty Change | 2 2 1 2 2 2 3 2 1 |
Hepatodiaphragmatic Nodule | 2 2 3 3 |
Hepatodiaphragmatic Nodule, Multiple | 3 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
Hyperplasia, Multifocal | 2 2 2 2 2 1 2 2 3 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Focal | 1 1 1 1 2 1|
Mixed Cell Focus | |
Pigmentation | |
Bile Duct, Hyperplasia | 1 3 1 3 2 2 1 2 2 2 2 3 3 3 3 3 3 1 2 3 3 2 1 2|
Centrilobular, Atrophy | 2 2 3 2 1 2 2 2 2 |
Centrilobular, Congestion | |
Centrilobular, Necrosis | 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Accessory Spleen | |
Fibrosis | |
Hemorrhage | 2 |
Fat, Necrosis | 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Atrophy, Focal | 3 2 1 2 2 1 1 1 2 |
Edema | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 6| 5| 4| 7| 3| 7| 2| 5| 5| 7| 5| 5| 6| 3| 6| 6| 7| 7| 4| 5|
DAY ON TEST | 3| 7| 3| 3| 8| 1| 5| 1| 1| 9| 3| 9| 0| 8| 3| 6| 4| 7| 8| 8| 6| 2| 0| 3| 5|
| 0| 3| 5| 0| 9| 7| 6| 9| 0| 2| 0| 9| 3| 4| 0| 1| 1| 4| 1| 0| 8| 9| 2| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 |
Inflammation, Chronic | 2 |
Mineralization, Focal | |
Ulcer | |
Mucosa, Hyperplasia | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Pigmentation, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + I + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Congestion | |
Focal Cellular Change | 2 1 1 |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Angiectasis | 1 |
Cyst | 3 |
Hemorrhage | |
Pars Distalis, Focal Cellular Change | 1 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
C-Cell, Hyperplasia | 1 1 3 |
Follicle, Dilatation | 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Anterior, Fibrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 6| 5| 4| 7| 3| 7| 2| 5| 5| 7| 5| 5| 6| 3| 6| 6| 7| 7| 4| 5|
DAY ON TEST | 3| 7| 3| 3| 8| 1| 5| 1| 1| 9| 3| 9| 0| 8| 3| 6| 4| 7| 8| 8| 6| 2| 0| 3| 5|
| 0| 3| 5| 0| 9| 7| 6| 9| 0| 2| 0| 9| 3| 4| 0| 1| 1| 4| 1| 0| 8| 9| 2| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
Anterior, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 2 3 2 2 2 2 2 2 1 4 2 2 2 1 2 2 2 2 2 2 2 2|
Hyperplasia | 2 2 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 2 3 2 3 1 1 1 2 1 2 3 1 1 1 1 2 2 3|
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | 1 |
Germinal Epithelium, Degeneration | 1 |
Interstitial Cell, Hyperplasia | 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
Hyperplasia, Focal, Histiocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Mediastinal, Congestion | 2 |
Mediastinal, Hyperplasia | 2 |
Pancreatic, Angiectasis | |
Pancreatic, Edema | 3 |
Pancreatic, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | |
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Congestion | 3 |
Cyst | 3 |
Fibrosis | 2 2 2 3 2 2 2 2 2 |
Hematopoietic Cell Proliferation | |
Necrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 6| 5| 4| 7| 3| 7| 2| 5| 5| 7| 5| 5| 6| 3| 6| 6| 7| 7| 4| 5|
DAY ON TEST | 3| 7| 3| 3| 8| 1| 5| 1| 1| 9| 3| 9| 0| 8| 3| 6| 4| 7| 8| 8| 6| 2| 0| 3| 5|
| 0| 3| 5| 0| 9| 7| 6| 9| 0| 2| 0| 9| 3| 4| 0| 1| 1| 4| 1| 0| 8| 9| 2| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 3 2 2 2 2 2 1|
Hyperplasia | 3 2 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hemorrhage, Focal | |
Inflammation, Chronic, Focal | 3 |
Ulcer | 3 |
Subcutaneous Tissue, Angiectasis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 3 3 3 |
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Edema | 2 |
Fibrosis, Focal | |
Hemorrhage, Focal | 1 |
Hyperplasia, Focal, Macrophage | 1 |
Necrosis, Focal | |
Alveolar Epithelium, Hyperplasia | 2 2 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 1 1 |
Inflammation, Suppurative | 1 2 2 2 |
__________________________________________________________________________|
Trachea | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 6| 5| 4| 7| 3| 7| 2| 5| 5| 7| 5| 5| 6| 3| 6| 6| 7| 7| 4| 5|
DAY ON TEST | 3| 7| 3| 3| 8| 1| 5| 1| 1| 9| 3| 9| 0| 8| 3| 6| 4| 7| 8| 8| 6| 2| 0| 3| 5|
| 0| 3| 5| 0| 9| 7| 6| 9| 0| 2| 0| 9| 3| 4| 0| 1| 1| 4| 1| 0| 8| 9| 2| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 4 3 2 4 3 4 3 2 4 1 3 1 2 2 3 2 2 4 2 3 3 3 4 2 2|
Pelvis, Dilatation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Hyperplasia, Oncocytic | |
Renal Tubule, Pigmentation | 1 3 1 1 2 1 2 1 1 1 1 1 3 2 2 2 2 2 1 2 3 2 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 5| 7| 6| 5| 6| 5| 6| 7| 5| 4|
DAY ON TEST | 4| 3| 1| 0| 4| 5| 2| 8| 1| 2| 3| 3| 4| 3| 3| 8| 2| 8| 0| 3| 1| 7| 2| 4| 5|
| 5| 0| 4| 2| 5| 1| 9| 9| 7| 2| 0| 0| 7| 0| 0| 8| 4| 0| 5| 1| 7| 3| 9| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy, Focal | 3 |
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | X X X X X|
Congestion, Focal | 2 2 |
Degeneration, Cystic | 2 1 |
Eosinophilic Focus | X X |
Fatty Change | 2 2 2 1 2 3 2|
Hepatodiaphragmatic Nodule | 2 3 3 |
Hepatodiaphragmatic Nodule, Multiple | 3 |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Multifocal | 2 2 3 2 |
Infiltration Cellular, Mixed Cell | 2 2 1 2 2 |
Inflammation, Focal | 1 1 2 1 1|
Mixed Cell Focus | X X |
Pigmentation | 3 |
Bile Duct, Hyperplasia | 2 2 3 3 4 2 2 2 2 1 2 2 2 2 3 2 1 3 3 2 3 2 2 1|
Centrilobular, Atrophy | 2 1 4 2 3 2 2 2 3 2 2 4 2 |
Centrilobular, Congestion | 3 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + +|
Accessory Spleen | 1|
Fibrosis | 2 |
Hemorrhage | |
Fat, Necrosis | 3 3 2 1 3 2 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | 3 |
Atrophy, Focal | 2 1 2 1 2 2 2 1 2 1 2 2 1 2 |
Edema | |
Necrosis | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 5| 7| 6| 5| 6| 5| 6| 7| 5| 4|
DAY ON TEST | 4| 3| 1| 0| 4| 5| 2| 8| 1| 2| 3| 3| 4| 3| 3| 8| 2| 8| 0| 3| 1| 7| 2| 4| 5|
| 5| 0| 4| 2| 5| 1| 9| 9| 7| 2| 0| 0| 7| 0| 0| 8| 4| 0| 5| 1| 7| 3| 9| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | |
Inflammation, Chronic | 2 |
Mineralization, Focal | |
Ulcer | 2 |
Mucosa, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 1 1 |
Pigmentation, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Congestion | 2 2 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 3 |
Hemorrhage | |
Pars Distalis, Focal Cellular Change | 2 1 1 1|
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
C-Cell, Hyperplasia | 2 1 |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | +|
Anterior, Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 5| 7| 6| 5| 6| 5| 6| 7| 5| 4|
DAY ON TEST | 4| 3| 1| 0| 4| 5| 2| 8| 1| 2| 3| 3| 4| 3| 3| 8| 2| 8| 0| 3| 1| 7| 2| 4| 5|
| 5| 0| 4| 2| 5| 1| 9| 9| 7| 2| 0| 0| 7| 0| 0| 8| 4| 0| 5| 1| 7| 3| 9| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
Anterior, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 1 2 1 2 2 2 3 1 2 1 2 2 2 2 2 2 2 2 2 2 1|
Hyperplasia | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 2 2 2 4 3 2 2 1 1 3 3 2 1 2 1 1|
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | |
Germinal Epithelium, Degeneration | 3 3 3 3 3 |
Interstitial Cell, Hyperplasia | 2 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 2 3 2 |
Hyperplasia, Focal, Histiocytic | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Mediastinal, Congestion | |
Mediastinal, Hyperplasia | |
Pancreatic, Angiectasis | 3 |
Pancreatic, Edema | 3 |
Pancreatic, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Cyst | |
Fibrosis | 3 2 2 |
Hematopoietic Cell Proliferation | 3 |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 5| 7| 6| 5| 6| 5| 6| 7| 5| 4|
DAY ON TEST | 4| 3| 1| 0| 4| 5| 2| 8| 1| 2| 3| 3| 4| 3| 3| 8| 2| 8| 0| 3| 1| 7| 2| 4| 5|
| 5| 0| 4| 2| 5| 1| 9| 9| 7| 2| 0| 0| 7| 0| 0| 8| 4| 0| 5| 1| 7| 3| 9| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 1 1 1 1 1 1 1 1 2 1 3 2 1 1 2 1 1 1 1 1 1 1 1 2 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + M|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Dilatation | 2 1 2 3 2 1 2 2 |
Hyperplasia | 2 2 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hemorrhage, Focal | 2 |
Inflammation, Chronic, Focal | |
Ulcer | |
Subcutaneous Tissue, Angiectasis | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 1 |
Hemorrhage | 3 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | |
Fibrosis, Focal | 2 |
Hemorrhage, Focal | |
Hyperplasia, Focal, Macrophage | 2 |
Necrosis, Focal | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 2 2 2 |
Inflammation, Suppurative | 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 5| 7| 6| 5| 6| 5| 6| 7| 5| 4|
DAY ON TEST | 4| 3| 1| 0| 4| 5| 2| 8| 1| 2| 3| 3| 4| 3| 3| 8| 2| 8| 0| 3| 1| 7| 2| 4| 5|
| 5| 0| 4| 2| 5| 1| 9| 9| 7| 2| 0| 0| 7| 0| 0| 8| 4| 0| 5| 1| 7| 3| 9| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 2 3 2 3 2 3 3 3 3 4 3 2 3 4 2 3 2 2 3 2 3 3 2 2|
Pelvis, Dilatation | 2 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 4 |
Renal Tubule, Hyperplasia, Oncocytic | 2 |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 1 2 2 3 2 2 2 2 2 3 2 1 2 3 3 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | 3 2 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Parasite Metazoan | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Parasite Metazoan | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Angiectasis | | 4 2.0|
Atrophy, Focal | | 1 3.0|
Basophilic Focus | X X X X X | 18 |
Clear Cell Focus | X | 8 |
Congestion, Focal | | 3 2.0|
Degeneration, Cystic | | 7 1.6|
Eosinophilic Focus | | 5 |
Fatty Change | 1 2 2 1 2 2 1 1 2 | 25 1.8|
Hepatodiaphragmatic Nodule | | 7 2.6|
Hepatodiaphragmatic Nodule, Multiple | | 2 3.0|
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Multifocal | | 13 2.1|
Infiltration Cellular, Mixed Cell | | 7 1.9|
Inflammation, Focal | 1 1 1 1 1 1 1 | 18 1.1|
Mixed Cell Focus | | 2 |
Pigmentation | | 1 3.0|
Bile Duct, Hyperplasia | 1 2 1 2 1 1 2 1 2 2 | 58 2.1|
Centrilobular, Atrophy | | 22 2.2|
Centrilobular, Congestion | | 1 3.0|
Centrilobular, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + | 18 |
Accessory Spleen | | 1 1.0|
Fibrosis | | 1 2.0|
Hemorrhage | | 1 2.0|
Fat, Necrosis | 3 | 12 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Accessory Spleen | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy, Focal | 2 2 1 2 2 2 2 | 30 1.7|
Edema | | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Erosion | | 1 2.0|
Inflammation, Chronic | | 2 2.0|
Mineralization, Focal | 2 | 1 2.0|
Ulcer | | 1 2.0|
Mucosa, Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 4 1.8|
Pigmentation, Focal | | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 59 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 2 1.0|
Congestion | | 2 2.0|
Focal Cellular Change | 1 | 4 1.3|
Hematopoietic Cell Proliferation | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 11 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Angiectasis | | 1 1.0|
Cyst | | 3 3.0|
Hemorrhage | 3 | 1 3.0|
Pars Distalis, Focal Cellular Change | 2 2 1 1 2 | 11 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | | 1 1.0|
C-Cell, Hyperplasia | 1 | 6 1.5|
Follicle, Dilatation | | 1 2.0|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Anterior, Fibrosis | | 1 4.0|
Anterior, Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 2 2 2 2 2 2 1 2 1 | 57 1.9|
Hyperplasia | | 4 2.0|
Inflammation, Chronic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 2 2 1 1 2 1 | 45 1.8|
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 | 2 1.5|
Germinal Epithelium, Degeneration | 2 | 7 2.6|
Interstitial Cell, Hyperplasia | 2 1 1 1 1 | 15 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 5 2.4|
Hyperplasia, Focal, Histiocytic | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 26 |
Mediastinal, Congestion | 2 2 | 3 2.0|
Mediastinal, Hyperplasia | | 1 2.0|
Pancreatic, Angiectasis | | 1 3.0|
Pancreatic, Edema | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Congestion | | 1 3.0|
Hyperplasia | | 7 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Edema | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia | 3 | 5 2.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Congestion | | 1 3.0|
Cyst | | 1 3.0|
Fibrosis | | 12 2.2|
Hematopoietic Cell Proliferation | | 1 3.0|
Necrosis, Focal | | 1 3.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 60 1.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
Congestion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Dilatation | 2 | 19 2.1|
Hyperplasia | | 6 2.2|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 |
Hemorrhage, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 1 3.0|
Ulcer | | 1 3.0|
Subcutaneous Tissue, Angiectasis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fracture | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 8 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage | | 2 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
Hemorrhage, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 3.0|
Edema | | 1 2.0|
Fibrosis, Focal | | 1 2.0|
Hemorrhage, Focal | | 1 1.0|
Hyperplasia, Focal, Macrophage | | 2 1.5|
Necrosis, Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 6 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 6 1.8|
Inflammation, Suppurative | | 8 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy | 2 2 2 2 2 1 2 2 2 2 | 60 2.6|
Pelvis, Dilatation | | 1 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 4.0|
Renal Tubule, Hyperplasia, Oncocytic | | 1 2.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 60 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | | 1 3.0|
Hemorrhage | | 2 2.5|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 6| 7| 3| 7| 6| 7| 6| 5| 7| 7| 5| 6| 7| 6| 7| 6| 5| 4| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 2| 0| 2| 9| 2| 7| 0| 7| 0| 2| 0| 8| 2| 2| 3| 0| 5| 2| 5| 2| 2| 2|
| 4| 2| 2| 9| 2| 9| 2| 9| 4| 0| 3| 5| 8| 2| 4| 4| 9| 7| 0| 2| 7| 4| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Fibrosis | 2 |
Inflammation, Chronic, Focal | |
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 1 |
Basophilic Focus | X X X X X 1 X X X X|
Clear Cell Focus | X X X X X X|
Congestion, Focal | 2 |
Degeneration, Cystic | 2 1 2 2 2|
Eosinophilic Focus | X X |
Fatty Change | 2 2 3 1 3 2 1|
Focal Cellular Change | 2 |
Hepatodiaphragmatic Nodule | |
Hepatodiaphragmatic Nodule, Multiple | 3 |
Hyperplasia, Multifocal | 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 1 |
Inflammation, Focal | 1 1 1 1 1 2 1|
Mixed Cell Focus | X|
Necrosis, Focal | 3 1 |
Bile Duct, Hyperplasia | 2 3 3 3 2 1 2 2 3 2 3 3 2 3 2 2 2 3 3 2 3 3 2|
Centrilobular, Atrophy | 2 2 1 2 2 2 3 1 2 3 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Accessory Spleen | 2 |
Angiectasis | |
Fat, Necrosis | 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 4 |
Atrophy, Focal | 1 2 1 1 2 2 2 1 1 1 3 4|
Edema | 3 |
Acinar Cell, Focal Cellular Change | |
Acinar Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 6| 7| 3| 7| 6| 7| 6| 5| 7| 7| 5| 6| 7| 6| 7| 6| 5| 4| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 2| 0| 2| 9| 2| 7| 0| 7| 0| 2| 0| 8| 2| 2| 3| 0| 5| 2| 5| 2| 2| 2|
| 4| 2| 2| 9| 2| 9| 2| 9| 4| 0| 3| 5| 8| 2| 4| 4| 9| 7| 0| 2| 7| 4| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Erosion | 1 |
Inflammation, Chronic | 3 3 |
Ulcer | 3 3 |
Mucosa, Hyperplasia | 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Pigmentation, Focal | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Focal Cellular Change | 2 2 1 1 |
Hematopoietic Cell Proliferation | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 1 2 2 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Cyst | 1 |
Pars Distalis, Focal Cellular Change | 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
C-Cell, Hyperplasia | 1 2 1 1 1 2 2|
Follicle, Dilatation | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 6| 7| 3| 7| 6| 7| 6| 5| 7| 7| 5| 6| 7| 6| 7| 6| 5| 4| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 2| 0| 2| 9| 2| 7| 0| 7| 0| 2| 0| 8| 2| 2| 3| 0| 5| 2| 5| 2| 2| 2|
| 4| 2| 2| 9| 2| 9| 2| 9| 4| 0| 3| 5| 8| 2| 4| 4| 9| 7| 0| 2| 7| 4| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Epithelium, Degeneration | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 2 2 2 1 1 1 2 2 3 2 2 3 2 1 2 2 2 2 3 2 2 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | 3 1 2 1 1 2 2 2 1 3 4 1 1 3 3 |
Epithelium, Hyperplasia, Focal | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 4 4 3 3 4 |
Interstitial Cell, Hyperplasia | 2 2 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
Hyperplasia, Focal, Histiocytic | 2 |
Metaplasia, Osseous | 2 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + |
Mediastinal, Angiectasis | 3 2 |
Mediastinal, Congestion | |
Mediastinal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Ectasia | 3 |
Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 2 2 3 2 2 2 |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Focal | 2 2 3 |
Pigmentation | 2 1 1 1 1 2 1 2 2 2 1 4 1 2 2 1 2 1 2 1 2 1 2 2 2|
Red Pulp, Hyperplasia, Focal, | |
Histiocytic | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 6| 7| 3| 7| 6| 7| 6| 5| 7| 7| 5| 6| 7| 6| 7| 6| 5| 4| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 2| 0| 2| 9| 2| 7| 0| 7| 0| 2| 0| 8| 2| 2| 3| 0| 5| 2| 5| 2| 2| 2|
| 4| 2| 2| 9| 2| 9| 2| 9| 4| 0| 3| 5| 8| 2| 4| 4| 9| 7| 0| 2| 7| 4| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 3 2 1 2 2 |
Hemorrhage | 2 2 |
Hyperplasia | 2 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Hyperkeratosis, Focal | 3 |
Epidermis, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 3 |
Hemorrhage | 3 |
Meninges, Fibrosis, Focal | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
Demyelination | |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 |
Hyperplasia, Diffuse, Macrophage | |
Hyperplasia, Focal, Macrophage | |
Alveolar Epithelium, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 3 2 2 2 3 |
Inflammation, Suppurative | 2 2 3 3 2 2 2 2 |
Respiratory Epithelium, Ulcer | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 6| 7| 3| 7| 6| 7| 6| 5| 7| 7| 5| 6| 7| 6| 7| 6| 5| 4| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 2| 0| 2| 9| 2| 7| 0| 7| 0| 2| 0| 8| 2| 2| 3| 0| 5| 2| 5| 2| 2| 2|
| 4| 2| 2| 9| 2| 9| 2| 9| 4| 0| 3| 5| 8| 2| 4| 4| 9| 7| 0| 2| 7| 4| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 2 |
Nephropathy | 4 2 2 3 2 3 2 4 2 3 2 3 3 2 2 2 3 2 3 2 2 2 3 3 3|
Pelvis, Dilatation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 1 |
Renal Tubule, Hyperplasia | 2 1 |
Renal Tubule, Pigmentation | 2 2 3 2 1 2 1 3 2 2 3 3 2 3 2 3 2 3 2 3 3 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 4| 4| 6| 5| 6| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 5| 7| 5| 7| 6| 7| 5| 3| 7|
DAY ON TEST | 2| 1| 9| 6| 3| 3| 2| 6| 7| 2| 0| 7| 2| 2| 2| 9| 8| 2| 3| 2| 4| 1| 8| 1| 2|
| 8| 5| 3| 5| 9| 1| 9| 1| 3| 9| 2| 3| 9| 9| 9| 1| 8| 2| 8| 9| 7| 0| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3 |
Fibrosis | |
Inflammation, Chronic, Focal | 3 |
Ulcer | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 2 |
Basophilic Focus | X X X X X X X X|
Clear Cell Focus | X X |
Congestion, Focal | |
Degeneration, Cystic | 2 1 2 2 2 |
Eosinophilic Focus | X X X |
Fatty Change | 2 2 1 3 2 2 |
Focal Cellular Change | |
Hepatodiaphragmatic Nodule | 3 2 |
Hepatodiaphragmatic Nodule, Multiple | |
Hyperplasia, Multifocal | 2 3 2 2 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 2|
Inflammation, Focal | 1 1 1|
Mixed Cell Focus | X |
Necrosis, Focal | 1 1 2 1 |
Bile Duct, Hyperplasia | 3 2 3 3 3 2 2 3 3 2 3 2 2 2 3 2 2 2 3 1 3 3 3 1 2|
Centrilobular, Atrophy | 2 2 2 3 1 2 2 3 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Accessory Spleen | 2 |
Angiectasis | 2 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | |
Atrophy, Focal | 3 1 2 3 2 1 1 2 2 2 2 2 2 2 1 1 |
Edema | |
Acinar Cell, Focal Cellular Change | 2 |
Acinar Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 4| 4| 6| 5| 6| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 5| 7| 5| 7| 6| 7| 5| 3| 7|
DAY ON TEST | 2| 1| 9| 6| 3| 3| 2| 6| 7| 2| 0| 7| 2| 2| 2| 9| 8| 2| 3| 2| 4| 1| 8| 1| 2|
| 8| 5| 3| 5| 9| 1| 9| 1| 3| 9| 2| 3| 9| 9| 9| 1| 8| 2| 8| 9| 7| 0| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 1 |
Pigmentation, Focal | 1 |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Focal Cellular Change | 1 2 2 |
Hematopoietic Cell Proliferation | 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 1 2 |
Pars Distalis, Focal Cellular Change | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
C-Cell, Hyperplasia | 2 1 2 |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 4| 4| 6| 5| 6| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 5| 7| 5| 7| 6| 7| 5| 3| 7|
DAY ON TEST | 2| 1| 9| 6| 3| 3| 2| 6| 7| 2| 0| 7| 2| 2| 2| 9| 8| 2| 3| 2| 4| 1| 8| 1| 2|
| 8| 5| 3| 5| 9| 1| 9| 1| 3| 9| 2| 3| 9| 9| 9| 1| 8| 2| 8| 9| 7| 0| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Epithelium, Degeneration | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 2 2 2 1 3 2 3 2 2 2 3 2 1 2 2 1 2 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Suppurative | 1 3 2 2 1 1 1 1 2 2 2 2 2 4 3 1 |
Epithelium, Hyperplasia, Focal | 2 2 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 3 4 4 4 3 3 |
Interstitial Cell, Hyperplasia | 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 3 |
Hyperplasia, Focal, Histiocytic | |
Metaplasia, Osseous | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Mediastinal, Angiectasis | 2 |
Mediastinal, Congestion | 3 2 |
Mediastinal, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | |
Hyperplasia | 2 2 1|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 3 3 2 2 |
Hematopoietic Cell Proliferation | 4 |
Necrosis, Focal | 2 |
Pigmentation | 1 1 1 1 2 2 2 1 1 1 1 2 1 2 1 3 1 2 1 2 1 1 1 1 2|
Red Pulp, Hyperplasia, Focal, | |
Histiocytic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 4| 4| 6| 5| 6| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 5| 7| 5| 7| 6| 7| 5| 3| 7|
DAY ON TEST | 2| 1| 9| 6| 3| 3| 2| 6| 7| 2| 0| 7| 2| 2| 2| 9| 8| 2| 3| 2| 4| 1| 8| 1| 2|
| 8| 5| 3| 5| 9| 1| 9| 1| 3| 9| 2| 3| 9| 9| 9| 1| 8| 2| 8| 9| 7| 0| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 2 2 |
Hemorrhage | |
Hyperplasia | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Hyperkeratosis, Focal | 3|
Epidermis, Hyperplasia, Focal | 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | 3 2 3 |
Meninges, Fibrosis, Focal | |
__________________________________________________________________________|
Peripheral Nerve | + + + |
__________________________________________________________________________|
Spinal Cord | + + |
Demyelination | 2 |
Hemorrhage, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 3 |
Hyperplasia, Diffuse, Macrophage | 3 |
Hyperplasia, Focal, Macrophage | 2 1 |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 |
Inflammation, Suppurative | 2 2 |
Respiratory Epithelium, Ulcer | |
__________________________________________________________________________|
Trachea | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 4| 4| 6| 5| 6| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 5| 7| 5| 7| 6| 7| 5| 3| 7|
DAY ON TEST | 2| 1| 9| 6| 3| 3| 2| 6| 7| 2| 0| 7| 2| 2| 2| 9| 8| 2| 3| 2| 4| 1| 8| 1| 2|
| 8| 5| 3| 5| 9| 1| 9| 1| 3| 9| 2| 3| 9| 9| 9| 1| 8| 2| 8| 9| 7| 0| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | |
Nephropathy | 2 1 2 3 2 1 3 2 3 3 2 2 3 3 3 2 2 2 2 4 3 2 2 3 2|
Pelvis, Dilatation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Pigmentation | 3 1 3 3 1 2 2 3 3 3 3 2 2 2 2 2 2 1 3 2 3 3 2 1 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | 1 | 4 1.5|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 4.0|
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Necrosis | | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Diverticulum | | 1 3.0|
Fibrosis | | 1 2.0|
Inflammation, Chronic, Focal | | 1 3.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 6 1.8|
Basophilic Focus | X | 19 1.0|
Clear Cell Focus | | 8 |
Congestion, Focal | | 1 2.0|
Degeneration, Cystic | 1 | 11 1.7|
Eosinophilic Focus | | 5 |
Fatty Change | 2 2 1 2 1 1 1 1 | 21 1.8|
Focal Cellular Change | | 1 2.0|
Hepatodiaphragmatic Nodule | | 2 2.5|
Hepatodiaphragmatic Nodule, Multiple | | 1 3.0|
Hyperplasia, Multifocal | | 12 2.1|
Infiltration Cellular, Mixed Cell | | 5 1.8|
Inflammation, Focal | 1 1 1 1 1 1 | 16 1.1|
Mixed Cell Focus | X | 3 |
Necrosis, Focal | | 6 1.5|
Bile Duct, Hyperplasia | 1 2 2 1 2 2 1 2 1 2 | 58 2.3|
Centrilobular, Atrophy | | 27 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 14 |
Accessory Spleen | | 2 2.0|
Angiectasis | | 1 2.0|
Fat, Necrosis | 2 | 5 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy, Diffuse | | 1 4.0|
Atrophy, Focal | 2 1 2 1 | 32 1.8|
Edema | | 1 3.0|
Acinar Cell, Focal Cellular Change | | 1 2.0|
Acinar Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Erosion | | 1 1.0|
Inflammation, Chronic | | 2 3.0|
Ulcer | | 2 3.0|
Mucosa, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Erosion | | 2 1.0|
Pigmentation, Focal | | 1 1.0|
Mucosa, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Focal Cellular Change | | 7 1.6|
Hematopoietic Cell Proliferation | | 1 1.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hyperplasia | | 8 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | | 3 2.3|
Cyst | 3 | 4 1.8|
Pars Distalis, Focal Cellular Change | 2 1 1 1 | 6 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | | 7 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | | 1 1.0|
C-Cell, Hyperplasia | 2 1 1 | 13 1.5|
Follicle, Dilatation | | 1 2.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 | 1 1.0|
Epithelium, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 2 2 2 1 2 1 1 2 1 1 | 57 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Hemorrhage | | 1 1.0|
Inflammation, Suppurative | 2 2 2 1 2 1 | 37 1.9|
Epithelium, Hyperplasia, Focal | | 7 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Germinal Epithelium, Degeneration | 4 | 12 3.6|
Interstitial Cell, Hyperplasia | 1 1 | 15 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 3 3.0|
Hyperplasia, Focal, Histiocytic | | 1 2.0|
Metaplasia, Osseous | | 1 2.0|
Myelofibrosis | 1 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 26 |
Mediastinal, Angiectasis | | 3 2.3|
Mediastinal, Congestion | | 2 2.5|
Mediastinal, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Congestion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Ectasia | | 1 3.0|
Hyperplasia | 2 | 8 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Edema | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 14 2.3|
Hematopoietic Cell Proliferation | | 2 3.0|
Necrosis, Focal | | 4 2.3|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 60 1.4|
Red Pulp, Hyperplasia, Focal, | | |
Histiocytic | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 59 |
Epithelial Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + M + | 57 |
Dilatation | | 11 2.2|
Hemorrhage | | 2 2.0|
Hyperplasia | | 3 2.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Hemorrhage, Focal | | 2 2.0|
Hyperkeratosis, Focal | | 2 3.0|
Epidermis, Hyperplasia, Focal | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 3 | 5 3.0|
Hemorrhage | | 4 2.8|
Meninges, Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 5 |
__________________________________________________________________________|____________|
Spinal Cord | | 4 |
Demyelination | | 1 2.0|
Hemorrhage, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage, Focal | | 3 1.7|
Hyperplasia, Diffuse, Macrophage | | 1 3.0|
Hyperplasia, Focal, Macrophage | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 6 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 2 | 9 2.2|
Inflammation, Suppurative | 2 | 11 2.2|
Respiratory Epithelium, Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 3.0|
Retina, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Cyst | | 1 2.0|
Nephropathy | 2 2 2 2 2 2 2 2 2 2 | 60 2.4|
Pelvis, Dilatation | 1 | 1 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 2 1.0|
Renal Tubule, Hyperplasia | | 3 1.7|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 2 1 1 1 | 60 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 7| 5| 7| 5| 5| 7| 6| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 0| 0| 2| 7| 2| 1| 2| 3| 0| 2| 6| 2| 4| 2| 0| 7| 0| 7| 2| 2| 2| 0| 2|
| 9| 1| 9| 2| 2| 2| 9| 7| 9| 2| 5| 9| 8| 9| 3| 9| 4| 3| 4| 9| 9| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | 1 2 1 2 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Autolysis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X|
Degeneration, Cystic | 2 1 2 2 1 |
Eosinophilic Focus | X X |
Fatty Change | 1 2 2 1 2 |
Fibrosis, Focal | 3 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 3 2 2 |
Hepatodiaphragmatic Nodule, Multiple | 3 |
Hyperplasia, Multifocal | 2 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 1 1 2 1 1 2 1 1 2 1 |
Mixed Cell Focus | X |
Necrosis, Focal | 1 2 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 1 2 3 2 3 3 2 2 3 2 3 3 2 3 1 2 2 3 2 2 2 2|
Centrilobular, Atrophy | 2 2 3 3 2 3 2 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Accessory Spleen | |
Fibrosis | |
Inflammation, Chronic | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Atrophy, Focal | 2 2 2 1 1 2 2 2 3 |
Inflammation, Chronic | |
Acinar Cell, Hyperplasia | 3 |
Artery, Inflammation, Chronic | 3 |
Duct, Dilatation | |
__________________________________________________________________________|
Pharynx | + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 7| 5| 7| 5| 5| 7| 6| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 0| 0| 2| 7| 2| 1| 2| 3| 0| 2| 6| 2| 4| 2| 0| 7| 0| 7| 2| 2| 2| 0| 2|
| 9| 1| 9| 2| 2| 2| 9| 7| 9| 2| 5| 9| 8| 9| 3| 9| 4| 3| 4| 9| 9| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | 2 2 |
Ulcer | 2 1 |
Mucosa, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia, Focal, Lymphoid | 2 |
Pigmentation, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | |
Atrophy | |
Focal Cellular Change | 1 2 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 2 2 1 1 1 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + A M M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 |
Hemorrhage | |
Pars Distalis, Focal Cellular Change | 2 1 2 |
Pars Distalis, Hyperplasia, Focal | 2 3 |
Pars Nervosa, Focal Cellular Change | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
Degeneration, Cystic | |
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 1 2 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 7| 5| 7| 5| 5| 7| 6| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 0| 0| 2| 7| 2| 1| 2| 3| 0| 2| 6| 2| 4| 2| 0| 7| 0| 7| 2| 2| 2| 0| 2|
| 9| 1| 9| 2| 2| 2| 9| 7| 9| 2| 5| 9| 8| 9| 3| 9| 4| 3| 4| 9| 9| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Degeneration, Cystic | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2|
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 2 2 1 1 4 1 1 1 2 2 3 3 2 1 1 |
Epithelium, Hyperplasia, Focal | 1 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + M + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
Germinal Epithelium, Degeneration | 4 2 4 3 4 3 |
Interstitial Cell, Hyperplasia | 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 3 3 2 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Inguinal, Hyperplasia | |
Mediastinal, Congestion | 3 2 |
Mediastinal, Hyperplasia | |
Mediastinal, Pigmentation | 2 2 |
Pancreatic, Angiectasis | |
Pancreatic, Edema | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + A + + + + + + +|
Angiectasis | 3 |
Congestion | |
Edema | 2 |
Hyperplasia | 2 1 2 1 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + + + + + + +|
Edema | 3 |
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Fibrosis | 1 2 4 1 2 |
Hematopoietic Cell Proliferation | 2 2 3 |
Necrosis, Focal | |
Pigmentation | 2 2 2 1 2 1 2 2 1 1 2 1 1 2 1 2 1 3 3 2 1 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 3 2 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 7| 5| 7| 5| 5| 7| 6| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 0| 0| 2| 7| 2| 1| 2| 3| 0| 2| 6| 2| 4| 2| 0| 7| 0| 7| 2| 2| 2| 0| 2|
| 9| 1| 9| 2| 2| 2| 9| 7| 9| 2| 5| 9| 8| 9| 3| 9| 4| 3| 4| 9| 9| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia | 3 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hyperkeratosis, Focal | 2 3 2 |
Hyperplasia, Focal | 3 |
Inflammation, Chronic, Focal | 3 2 |
Ulcer | 4 |
Epidermis, Hyperplasia, Focal | 2 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Trabecula, Proliferation | 4 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 4 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | |
Hemorrhage, Focal | 1 |
Hyperplasia, Focal, Macrophage | |
Infiltration Cellular, Mixed Cell | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 1 |
Inflammation, Suppurative | 2 2 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Atrophy | 3 |
Cataract | 3 3 |
Retina, Degeneration | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 7| 5| 7| 5| 5| 7| 6| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 0| 0| 2| 7| 2| 1| 2| 3| 0| 2| 6| 2| 4| 2| 0| 7| 0| 7| 2| 2| 2| 0| 2|
| 9| 1| 9| 2| 2| 2| 9| 7| 9| 2| 5| 9| 8| 9| 3| 9| 4| 3| 4| 9| 9| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Autolysis | 2 |
Infarct | |
Nephropathy | 2 2 2 2 2 2 2 2 1 2 2 1 2 2 1 2 2 2 3 4 2 3 2 2 2|
Thrombosis | |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Hyperplasia, Oncocytic | |
Renal Tubule, Pigmentation | 2 2 3 2 3 2 3 3 3 2 2 2 2 2 2 2 3 2 2 2 3 2 2 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 4| 6| 7| 6| 7| 6| 7| 6| 5| 7| 5| 5|
DAY ON TEST | 2| 3| 0| 7| 8| 9| 2| 6| 7| 7| 0| 5| 2| 2| 8| 0| 7| 2| 5| 0| 3| 0| 2| 5| 7|
| 9| 2| 6| 3| 8| 6| 8| 8| 4| 4| 6| 1| 9| 6| 7| 0| 9| 9| 7| 2| 1| 6| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 |
Autolysis | |
Basophilic Focus | X X X X X X X X|
Clear Cell Focus | X X |
Degeneration, Cystic | 2 2 1 2 2 |
Eosinophilic Focus | X X X X X |
Fatty Change | 2 1 1 3 3 1 |
Fibrosis, Focal | |
Focal Cellular Change | 1 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 2 2 2 2 |
Hepatodiaphragmatic Nodule, Multiple | |
Hyperplasia, Multifocal | 2 3 2 2 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 2|
Inflammation, Focal | 2 2 2 1 2 |
Mixed Cell Focus | |
Necrosis, Focal | |
Thrombosis | 2 2 |
Bile Duct, Hyperplasia | 4 3 2 2 3 2 2 3 4 3 3 3 3 2 2 2 3 2 2 2 2 3 2 3 2|
Centrilobular, Atrophy | 1 4 2 2 3 3 1 2 2 4 2 2 2 2 1 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Accessory Spleen | |
Fibrosis | 2 |
Inflammation, Chronic | 1 |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 3 2 2 2 2 2 1 2 2 1 2 2 1 1|
Inflammation, Chronic | 2 |
Acinar Cell, Hyperplasia | 1 |
Artery, Inflammation, Chronic | |
Duct, Dilatation | 1 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 4| 6| 7| 6| 7| 6| 7| 6| 5| 7| 5| 5|
DAY ON TEST | 2| 3| 0| 7| 8| 9| 2| 6| 7| 7| 0| 5| 2| 2| 8| 0| 7| 2| 5| 0| 3| 0| 2| 5| 7|
| 9| 2| 6| 3| 8| 6| 8| 8| 4| 4| 6| 1| 9| 6| 7| 0| 9| 9| 7| 2| 1| 6| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Chronic | 3 |
Ulcer | 2 2 |
Mucosa, Hyperplasia | 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Focal, Lymphoid | |
Pigmentation, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Angiectasis | 2 |
Atrophy | 2 |
Focal Cellular Change | 1 1 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + I + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Cyst | 2 2 |
Hemorrhage | 2 |
Pars Distalis, Focal Cellular Change | 2 2 1 |
Pars Distalis, Hyperplasia, Focal | 4 2 |
Pars Nervosa, Focal Cellular Change | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 4| 6| 7| 6| 7| 6| 7| 6| 5| 7| 5| 5|
DAY ON TEST | 2| 3| 0| 7| 8| 9| 2| 6| 7| 7| 0| 5| 2| 2| 8| 0| 7| 2| 5| 0| 3| 0| 2| 5| 7|
| 9| 2| 6| 3| 8| 6| 8| 8| 4| 4| 6| 1| 9| 6| 7| 0| 9| 9| 7| 2| 1| 6| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Degeneration, Cystic | 2 2 3 2 2 2 2 2 2 2 3 3 3 2 2 4 2 3 2 2 2 2 2 1|
Hyperplasia | 2 |
Inflammation, Chronic | 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 1 3 2 2 2 1 2 1 1 1 2 3 2 1 1 2 2 2|
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | 1 |
Germinal Epithelium, Degeneration | 3 3 4 4 4 4 2 |
Interstitial Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Inguinal, Hyperplasia | 2 |
Mediastinal, Congestion | 3 2 |
Mediastinal, Hyperplasia | |
Mediastinal, Pigmentation | 2 |
Pancreatic, Angiectasis | 4 |
Pancreatic, Edema | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 2 |
Edema | |
Hyperplasia | 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 |
Fibrosis | 3 2 2 2 3 2 2 |
Hematopoietic Cell Proliferation | 4 3 2 3 |
Necrosis, Focal | 2 |
Pigmentation | 1 2 3 2 1 2 2 1 1 1 2 1 1 2 1 1 1 2 1 1 1 1 2 1 2|
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Dilatation | 2 3 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 4| 6| 7| 6| 7| 6| 7| 6| 5| 7| 5| 5|
DAY ON TEST | 2| 3| 0| 7| 8| 9| 2| 6| 7| 7| 0| 5| 2| 2| 8| 0| 7| 2| 5| 0| 3| 0| 2| 5| 7|
| 9| 2| 6| 3| 8| 6| 8| 8| 4| 4| 6| 1| 9| 6| 7| 0| 9| 9| 7| 2| 1| 6| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hyperkeratosis, Focal | 2 |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | 3 |
Ulcer | |
Epidermis, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
Trabecula, Proliferation | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 1 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Fibrosis, Focal | 2 |
Hemorrhage, Focal | 2 2 |
Hyperplasia, Focal, Macrophage | 2 2 |
Infiltration Cellular, Mixed Cell | 2 |
Alveolar Epithelium, Hyperplasia | 1 2 2 1 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 3 |
Inflammation, Suppurative | 2 2 3 2 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Atrophy | |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 4| 6| 7| 6| 7| 6| 7| 6| 5| 7| 5| 5|
DAY ON TEST | 2| 3| 0| 7| 8| 9| 2| 6| 7| 7| 0| 5| 2| 2| 8| 0| 7| 2| 5| 0| 3| 0| 2| 5| 7|
| 9| 2| 6| 3| 8| 6| 8| 8| 4| 4| 6| 1| 9| 6| 7| 0| 9| 9| 7| 2| 1| 6| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Autolysis | |
Infarct | 3 |
Nephropathy | 2 1 2 2 2 2 2 2 2 2 1 2 2 1 2 1 2 2 1 2 2 2 3 2 2|
Thrombosis | 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Hyperplasia, Oncocytic | 1 |
Renal Tubule, Pigmentation | 3 2 3 2 3 2 2 2 2 3 2 2 3 2 3 2 3 2 2 2 3 3 3 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Parasite Metazoan | | 5 1.4|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 6 2.0|
Autolysis | | 1 3.0|
Basophilic Focus | X X X X X | 30 |
Clear Cell Focus | | 9 |
Degeneration, Cystic | 1 | 11 1.6|
Eosinophilic Focus | | 7 |
Fatty Change | 2 2 2 1 1 2 1 1 1 1 | 21 1.6|
Fibrosis, Focal | | 1 3.0|
Focal Cellular Change | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | 3 3 3 2 1 | 12 2.3|
Hepatodiaphragmatic Nodule, Multiple | | 1 3.0|
Hyperplasia, Multifocal | | 13 2.1|
Infiltration Cellular, Mixed Cell | | 4 2.0|
Inflammation, Focal | 1 1 1 1 1 1 1 | 22 1.3|
Mixed Cell Focus | | 1 |
Necrosis, Focal | | 3 1.7|
Thrombosis | | 2 2.0|
Bile Duct, Hyperplasia | 2 1 1 1 1 2 2 2 1 2 | 59 2.3|
Centrilobular, Atrophy | | 23 2.3|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 15 |
Accessory Spleen | 2 | 1 2.0|
Fibrosis | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Fat, Necrosis | 3 | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy, Focal | 2 1 1 2 | 29 1.7|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinar Cell, Hyperplasia | | 2 2.0|
Artery, Inflammation, Chronic | | 1 3.0|
Duct, Dilatation | | 2 1.5|
__________________________________________________________________________|____________|
Pharynx | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Inflammation, Chronic | | 3 2.3|
Ulcer | | 4 1.8|
Mucosa, Hyperplasia | | 5 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Erosion | | 1 2.0|
Hyperplasia, Focal, Lymphoid | | 1 2.0|
Pigmentation, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Thrombosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 2 1.5|
Angiectasis | | 1 2.0|
Atrophy | | 1 2.0|
Focal Cellular Change | 1 2 | 11 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 15 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Angiectasis | 4 | 3 2.3|
Cyst | | 3 2.0|
Hemorrhage | | 1 2.0|
Pars Distalis, Focal Cellular Change | | 6 1.7|
Pars Distalis, Hyperplasia, Focal | | 4 2.8|
Pars Nervosa, Focal Cellular Change | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Ultimobranchial Cyst | | 2 1.5|
C-Cell, Hyperplasia | | 5 1.6|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 2 3 2 1 1 1 1 1 2 2 | 58 2.0|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 2 | 3 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 1 1 2 1 2 1 1 | 43 1.7|
Epithelium, Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 | 3 1.7|
Germinal Epithelium, Degeneration | | 13 3.4|
Interstitial Cell, Hyperplasia | 2 2 | 9 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 6 2.7|
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 32 |
Inguinal, Hyperplasia | | 1 2.0|
Mediastinal, Congestion | 2 1 | 6 2.2|
Mediastinal, Hyperplasia | 3 | 1 3.0|
Mediastinal, Pigmentation | | 3 2.0|
Pancreatic, Angiectasis | | 1 4.0|
Pancreatic, Edema | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Angiectasis | | 1 3.0|
Congestion | 2 | 2 2.0|
Edema | | 1 2.0|
Hyperplasia | 3 | 7 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Edema | | 2 3.5|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Degeneration, Fatty | | 1 2.0|
Fibrosis | | 12 2.2|
Hematopoietic Cell Proliferation | | 7 2.7|
Necrosis, Focal | | 1 2.0|
Pigmentation | 1 1 2 1 2 2 2 2 1 1 | 60 1.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + M + + | 58 |
Dilatation | | 18 2.1|
Hyperplasia | | 2 2.5|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Hemorrhage, Focal | 2 | 1 2.0|
Hyperkeratosis, Focal | | 4 2.3|
Hyperplasia, Focal | | 1 3.0|
Inflammation, Chronic, Focal | | 3 2.7|
Ulcer | | 1 4.0|
Epidermis, Hyperplasia, Focal | | 4 2.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 1 2.0|
Trabecula, Proliferation | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 5 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Congestion | | 2 2.0|
Fibrosis, Focal | | 1 2.0|
Hemorrhage, Focal | | 3 1.7|
Hyperplasia, Focal, Macrophage | | 2 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 7 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 8 2.0|
Inflammation, Suppurative | 1 | 12 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | | 2 |
Atrophy | | 1 3.0|
Cataract | | 2 3.0|
Retina, Degeneration | | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Autolysis | | 1 2.0|
Infarct | | 1 3.0|
Nephropathy | 2 1 2 2 2 2 2 1 2 2 | 60 1.9|
Thrombosis | | 1 2.0|
Renal Tubule, Hyperplasia | 2 | 2 1.5|
Renal Tubule, Hyperplasia, Oncocytic | | 1 1.0|
Renal Tubule, Pigmentation | 2 2 1 2 2 2 2 2 2 2 | 60 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 4| 7| 7| 7| 1| 4| 7| 6| 7| 7| 5| 7| 5| 6| 7| 7| 6| 5|
DAY ON TEST | 1| 2| 2| 2| 4| 1| 1| 8| 2| 2| 2| 9| 5| 2| 1| 1| 0| 0| 2| 0| 9| 2| 2| 1| 4|
| 8| 9| 9| 9| 2| 0| 5| 3| 9| 9| 9| 1| 8| 9| 8| 0| 3| 6| 9| 6| 5| 9| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X |
Degeneration, Cystic | 1 2 2 2 |
Developmental Malformation | |
Eosinophilic Focus | X |
Fatty Change | 1 1 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage, Focal | 3 |
Hepatodiaphragmatic Nodule | 3 2 2 |
Hyperplasia, Multifocal | 2 2 |
Infiltration Cellular, Mixed Cell | 3 2 |
Inflammation, Focal | 1 2 1 1 1 2 2 1 1 1 1 1 1 2 1|
Mixed Cell Focus | X |
Necrosis, Focal | 3 |
Bile Duct, Hyperplasia | 2 3 2 3 2 2 2 2 2 3 2 2 2 2 3 2 1 3 2 2 2 2 2 2|
Centrilobular, Atrophy | 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Accessory Spleen | 2 |
Fibrosis | 3 |
Inflammation, Chronic | 2 |
Fat, Necrosis | 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Atrophy, Focal | 2 2 1 2 2 1 2 1 1 2 2 1 2 |
Inflammation, Chronic | |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 4| 7| 7| 7| 1| 4| 7| 6| 7| 7| 5| 7| 5| 6| 7| 7| 6| 5|
DAY ON TEST | 1| 2| 2| 2| 4| 1| 1| 8| 2| 2| 2| 9| 5| 2| 1| 1| 0| 0| 2| 0| 9| 2| 2| 1| 4|
| 8| 9| 9| 9| 2| 0| 5| 3| 9| 9| 9| 1| 8| 9| 8| 0| 3| 6| 9| 6| 5| 9| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | |
Focal Cellular Change | 1 1 2 1 2 1|
Hyperplasia, Focal | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Cyst | 2 |
Pars Distalis, Focal Cellular Change | 2 1 2 1 |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 2 1 2 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Oral, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 2 1 3 3 2 2 2 2 1 2 2 2 3 3 2 2 2 2 2 2 2|
Hyperplasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 2 3 2 3 1 2 2 2 4 1 2 1 1 1 1 1 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 4| 7| 7| 7| 1| 4| 7| 6| 7| 7| 5| 7| 5| 6| 7| 7| 6| 5|
DAY ON TEST | 1| 2| 2| 2| 4| 1| 1| 8| 2| 2| 2| 9| 5| 2| 1| 1| 0| 0| 2| 0| 9| 2| 2| 1| 4|
| 8| 9| 9| 9| 2| 0| 5| 3| 9| 9| 9| 1| 8| 9| 8| 0| 3| 6| 9| 6| 5| 9| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Mineralization, Focal | |
Artery, Inflammation, Chronic | |
Bilateral, Interstitial Cell, | |
Hyperplasia | 1 1 1 1 2 |
Germinal Epithelium, Degeneration | 4 3 3 3 4 3 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hypercellularity | 2 3 |
Hyperplasia, Focal, Histiocytic | 2 1 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Inguinal, Hyperplasia | 4 2 3 |
Lumbar, Hyperplasia | 4 |
Mediastinal, Angiectasis | 3 |
Mediastinal, Congestion | 3 2 |
Mediastinal, Hyperplasia | 3 3 |
Pancreatic, Angiectasis | 3 |
Pancreatic, Edema | 2 |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Macrophage | |
Pancreatic, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hemorrhage | 2 |
Hyperplasia | 3 2 2 3 3 3 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 4 3 2 |
Pigmentation | 1 3 2 3 1 2 2 2 3 3 2 3 3 2 3 2 3 3 3 1 2 2 2 2 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + M + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 4| 7| 7| 7| 1| 4| 7| 6| 7| 7| 5| 7| 5| 6| 7| 7| 6| 5|
DAY ON TEST | 1| 2| 2| 2| 4| 1| 1| 8| 2| 2| 2| 9| 5| 2| 1| 1| 0| 0| 2| 0| 9| 2| 2| 1| 4|
| 8| 9| 9| 9| 2| 0| 5| 3| 9| 9| 9| 1| 8| 9| 8| 0| 3| 6| 9| 6| 5| 9| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Dilatation | 1 2 1 1 1 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Hyperkeratosis, Focal | 3 |
Inflammation, Chronic, Focal | |
Ulcer | |
Epidermis, Hyperplasia, Focal | 3 |
Subcutaneous Tissue, Congestion | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | 3 |
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Infiltration Cellular, Mixed Cell | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 3 |
Inflammation, Suppurative | 2 3 |
Respiratory Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 4| 7| 7| 7| 1| 4| 7| 6| 7| 7| 5| 7| 5| 6| 7| 7| 6| 5|
DAY ON TEST | 1| 2| 2| 2| 4| 1| 1| 8| 2| 2| 2| 9| 5| 2| 1| 1| 0| 0| 2| 0| 9| 2| 2| 1| 4|
| 8| 9| 9| 9| 2| 0| 5| 3| 9| 9| 9| 1| 8| 9| 8| 0| 3| 6| 9| 6| 5| 9| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 2 2 1 1 2 2 2 2 1 1 1 2 1 2 2 3 2 2 2 1 2 2 3 1 2|
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Hyperplasia, Oncocytic | 1 |
Renal Tubule, Pigmentation | 2 3 3 3 3 3 3 2 3 2 3 1 2 3 3 3 3 2 3 3 3 3 2 3 3|
Renal Tubule, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 2| 4| 2| 2| 2| 9| 8| 1| 6| 2| 2| 9| 2| 2| 3| 5| 0| 4| 2| 0| 8| 2| 2|
| 2| 9| 9| 7| 9| 9| 9| 4| 9| 9| 7| 9| 9| 6| 0| 9| 4| 4| 0| 5| 9| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X|
Degeneration, Cystic | 1 2 1 1 2 1 2 2|
Developmental Malformation | 2 |
Eosinophilic Focus | X X X X|
Fatty Change | 1 2 2 1 |
Hematopoietic Cell Proliferation | 2 1 |
Hemorrhage, Focal | |
Hepatodiaphragmatic Nodule | 2 2 2 3 3 3|
Hyperplasia, Multifocal | 2 1 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 1 1 2 1 1 1 1 2 2 1 1|
Mixed Cell Focus | X |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 3 2 2 2 1 2 2 2 2 2 2 3 2 2 1 1 2 2 3 2 2 2 2|
Centrilobular, Atrophy | 1 2 2 1 |
Centrilobular, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + |
Accessory Spleen | |
Fibrosis | |
Inflammation, Chronic | |
Fat, Necrosis | 3 2 3 3 2 3 2 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Atrophy, Focal | 1 2 1 2 1 2 1 2 |
Inflammation, Chronic | 2 |
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
Hyperplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 2| 4| 2| 2| 2| 9| 8| 1| 6| 2| 2| 9| 2| 2| 3| 5| 0| 4| 2| 0| 8| 2| 2|
| 2| 9| 9| 7| 9| 9| 9| 4| 9| 9| 7| 9| 9| 6| 0| 9| 4| 4| 0| 5| 9| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | 2 |
Focal Cellular Change | 1 2 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + I + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 3 2 |
Pars Distalis, Focal Cellular Change | 2 1 1 2 1 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Oral, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 2 3 1 2 1 3 3 2 2 2 2 2 3 2 2 4 2 1 2 2 2 2 3|
Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 2 3 2 1 2 3 2 1 1 2 2 1 2 1 2 3 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 2| 4| 2| 2| 2| 9| 8| 1| 6| 2| 2| 9| 2| 2| 3| 5| 0| 4| 2| 0| 8| 2| 2|
| 2| 9| 9| 7| 9| 9| 9| 4| 9| 9| 7| 9| 9| 6| 0| 9| 4| 4| 0| 5| 9| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Mineralization, Focal | 1 |
Artery, Inflammation, Chronic | 2 |
Bilateral, Interstitial Cell, | |
Hyperplasia | 1 1 |
Germinal Epithelium, Degeneration | 3 3 2 4 3 2 3 2 |
Interstitial Cell, Hyperplasia | 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
Hypercellularity | 2 3 2 |
Hyperplasia, Focal, Histiocytic | |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Inguinal, Hyperplasia | 2 |
Lumbar, Hyperplasia | |
Mediastinal, Angiectasis | |
Mediastinal, Congestion | 3 3 |
Mediastinal, Hyperplasia | 2 3 |
Pancreatic, Angiectasis | |
Pancreatic, Edema | |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia, Macrophage | 3 |
Pancreatic, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia | 2 2 2 3 2 2 3 4 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Edema | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia | 3 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 3 4 |
Hematopoietic Cell Proliferation | 3 3 3 3 3 2 |
Pigmentation | 1 3 3 2 2 2 2 1 1 3 1 3 3 3 2 3 1 2 2 1 2 3 2 3 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + M + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + M + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 2| 4| 2| 2| 2| 9| 8| 1| 6| 2| 2| 9| 2| 2| 3| 5| 0| 4| 2| 0| 8| 2| 2|
| 2| 9| 9| 7| 9| 9| 9| 4| 9| 9| 7| 9| 9| 6| 0| 9| 4| 4| 0| 5| 9| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Dilatation | 1 3 3 2 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Hyperkeratosis, Focal | 2|
Inflammation, Chronic, Focal | 2|
Ulcer | |
Epidermis, Hyperplasia, Focal | 2|
Subcutaneous Tissue, Congestion | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | 3 |
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Infiltration Cellular, Mixed Cell | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 2 3 |
Inflammation, Suppurative | 2 2 2 2 3 2 |
Respiratory Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 3 |
Cataract | 4 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 2| 4| 2| 2| 2| 9| 8| 1| 6| 2| 2| 9| 2| 2| 3| 5| 0| 4| 2| 0| 8| 2| 2|
| 2| 9| 9| 7| 9| 9| 9| 4| 9| 9| 7| 9| 9| 6| 0| 9| 4| 4| 0| 5| 9| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 2 1 1 2 2 1 1 1 2 1 2 2 2 1 2 1 1 2 1 2 1 2 1 1 2|
Renal Tubule, Hyperplasia | |
Renal Tubule, Hyperplasia, Oncocytic | 2 3 1 1 |
Renal Tubule, Pigmentation | 3 3 2 2 2 3 2 3 3 2 3 2 2 3 3 2 2 3 3 1 2 3 4 3 3|
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + M + + + + + + + + | 59 |
Parasite Metazoan | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X | 35 |
Clear Cell Focus | | 12 |
Degeneration, Cystic | | 12 1.6|
Developmental Malformation | | 1 2.0|
Eosinophilic Focus | | 5 |
Fatty Change | 1 1 1 1 2 1 1 1 1 | 16 1.3|
Hematopoietic Cell Proliferation | | 2 1.5|
Hemorrhage, Focal | | 1 3.0|
Hepatodiaphragmatic Nodule | | 9 2.4|
Hyperplasia, Multifocal | | 4 1.8|
Infiltration Cellular, Mixed Cell | | 3 2.3|
Inflammation, Focal | 1 1 1 1 1 1 | 32 1.2|
Mixed Cell Focus | | 2 |
Necrosis, Focal | | 1 3.0|
Bile Duct, Hyperplasia | 1 2 2 1 2 2 2 2 2 1 | 58 2.0|
Centrilobular, Atrophy | | 5 1.4|
Centrilobular, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 20 |
Accessory Spleen | | 1 2.0|
Fibrosis | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | 2 2 3 | 16 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Accessory Spleen | 3 | 1 3.0|
Atrophy, Focal | 2 2 1 2 2 1 | 27 1.6|
Inflammation, Chronic | | 1 2.0|
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tongue | | 2 |
Hyperplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 1 2.0|
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | 1 | 3 1.0|
Angiectasis | | 1 2.0|
Focal Cellular Change | 1 | 9 1.3|
Hyperplasia, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 9 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Angiectasis | 3 | 4 2.0|
Cyst | 2 | 4 2.3|
Pars Distalis, Focal Cellular Change | 1 1 1 | 12 1.3|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | | 2 1.5|
Ultimobranchial Cyst | 1 | 2 1.5|
C-Cell, Hyperplasia | | 9 1.7|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Oral, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 2 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 2 1 2 2 2 1 1 2 1 | 58 2.1|
Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 2 2 2 1 | 44 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Mineralization, Focal | | 1 1.0|
Artery, Inflammation, Chronic | | 1 2.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia | 4 1 1 | 10 1.4|
Germinal Epithelium, Degeneration | | 14 3.0|
Interstitial Cell, Hyperplasia | 1 1 1 | 17 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hemorrhage | | 2 2.5|
Hypercellularity | | 5 2.4|
Hyperplasia, Focal, Histiocytic | | 3 2.0|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 15 |
Inguinal, Hyperplasia | | 4 2.8|
Lumbar, Hyperplasia | | 1 4.0|
Mediastinal, Angiectasis | | 1 3.0|
Mediastinal, Congestion | 2 | 5 2.6|
Mediastinal, Hyperplasia | | 4 2.8|
Pancreatic, Angiectasis | | 1 3.0|
Pancreatic, Edema | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Hyperplasia, Macrophage | | 1 3.0|
Pancreatic, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Congestion | | 2 2.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | | 16 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Edema | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 3 2.7|
Hyperplasia | | 7 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 7 2.4|
Hematopoietic Cell Proliferation | | 9 2.9|
Pigmentation | 2 2 2 2 1 2 2 2 2 2 | 60 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
Cyst | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + + + + + + + | 54 |
Dilatation | | 9 1.7|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Exudate | 3 | 1 3.0|
Hyperkeratosis, Focal | | 2 2.5|
Inflammation, Chronic, Focal | 2 | 2 2.0|
Ulcer | 2 | 1 2.0|
Epidermis, Hyperplasia, Focal | | 2 2.5|
Subcutaneous Tissue, Congestion | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fracture | | 2 3.0|
Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 2 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
NTP Experiment-Test: 05155-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 04/18/97
Route: DOSED FEED Time: 13:00:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 3.0|
Infiltration Cellular, Mixed Cell | | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 2 | 8 2.3|
Inflammation, Suppurative | 2 | 9 2.2|
Respiratory Epithelium, Hyperplasia, | | |
Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 3.0|
Cataract | | 1 4.0|
Retina, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 3.0|
Nephropathy | 2 2 2 1 1 1 2 2 2 2 | 60 1.6|
Renal Tubule, Hyperplasia | | 1 2.0|
Renal Tubule, Hyperplasia, Oncocytic | | 5 1.6|
Renal Tubule, Pigmentation | 2 2 2 2 3 3 2 3 3 2 | 60 2.6|
Renal Tubule, Vacuolization | | |
Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------