TDMS Study 05155-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 05/08/95
EXP: 05155 P-NITROBENZOIC ACID TIME: 17:37:59
TEST: 03 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 61778B
CONT: N01-ES-85217 CAS: 62-23-7
PATHOLOGIST: DR D. FARNELL HAILEY, JAMES R.
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REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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TREATMENT GROUPS:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 05/08/95
EXP: 05155 P-NITROBENZOIC ACID TIME: 17:37:59
TEST: 03 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 61778B
CONT: N01-ES-85217 CAS: 62-23-7
PATHOLOGIST: DR D. FARNELL HAILEY, JAMES R.
P-NITROBENZOIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 38 CENSORED DEATHS 10 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 246 299 381 392 419 438 451 503 505 517 |
| 535 541 547 548 556 556 561 584 588 602 |
| 617 617 631 645 645 668 673 673 674 680 |
| 680 689 689 702 710 714 722 724 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.125% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 37 CENSORED DEATHS 10 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 310 392 415 454 493 505 527 532 532 538 |
| 539 561 584 587 588 591 602 624 631 637 |
| 647 652 665 673 673 673 674 674 700 700 |
| 702 702 710 722 722 728 728 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 37 CENSORED DEATHS 10 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 426 505 506 506 506 517 532 541 556 568 |
| 570 573 588 604 604 609 631 632 643 651 |
| 657 668 672 673 674 674 679 679 687 696 |
| 700 702 702 709 722 728 728 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
P-NITROBENZOIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.5% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 29 CENSORED DEATHS 10 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 191 434 445 458 483 506 506 518 532 542 |
| 548 567 608 615 617 618 647 654 681 689 |
| 694 695 696 700 703 710 710 719 720 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
P-NITROBENZOIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 98.3 96.7 91.7 88.3 78.1 61.6 51.4 24.7 |
| | |
| | |
|0.125% | 100.0 100.0 100.0 98.3 95.0 93.3 79.1 67.0 54.8 26.4 |
| | |
| | |
|0.25% | 100.0 100.0 100.0 100.0 100.0 98.3 84.3 70.2 58.2 26.1 |
| | |
| | |
|0.5% | 100.0 100.0 98.3 98.3 98.3 91.0 80.9 76.8 64.7 42.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 0.125% 0.25% 0.5% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 24.7% 26.4% 26.1% 42.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.038N P=0.651N P=0.563N P=0.053N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 576.9 605.1 622.1 593.3 |
|NATURAL DEATHS (C) | (19.5) (16.9) (12.9) (22.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 587.2 607.1 617.6 617.9 |
|(STANDARD ERROR) | (16.4) (15.1) (13.5) (16.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P-NITROBENZOIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 23 CENSORED DEATHS 10 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 490 556 566 605 631 647 653 657 664 667 |
| 679 679 680 687 694 700 700 702 702 709 |
| 714 722 724 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.125% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 27 CENSORED DEATHS 10 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 150 441 483 496 510 521 548 566 570 632 |
| 651 665 674 674 674 676 694 695 696 696 |
| 696 696 700 702 702 708 728 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 29 CENSORED DEATHS 10 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 241 379 379 434 461 492 496 499 518 538 |
| 553 588 604 643 647 647 650 653 664 668 |
| 685 694 695 695 702 702 708 709 714 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
P-NITROBENZOIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.5% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 29 CENSORED DEATHS 10 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 441 483 493 518 528 532 541 556 565 574 |
| 602 611 618 622 674 687 689 695 695 700 |
| 702 702 707 708 708 709 709 714 714 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
P-NITROBENZOIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 92.0 82.0 54.0 |
| | |
| | |
|0.125% | 100.0 98.3 98.3 98.3 98.3 94.7 88.6 82.6 76.5 46.3 |
| | |
| | |
|0.25% | 100.0 100.0 98.3 98.3 95.0 91.3 81.2 75.1 62.9 42.6 |
| | |
| | |
|0.5% | 100.0 100.0 100.0 100.0 100.0 96.3 86.3 78.3 72.2 42.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 0.125% 0.25% 0.5% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 54.0% 46.3% 42.6% 42.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.250 P=0.400 P=0.137 P=0.231 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 662.1 616.4 588.2 627.5 |
|NATURAL DEATHS (C) | (12.2) (24.1) (22.9) (16.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 658.5 633.4 616.0 635.0 |
|(STANDARD ERROR) | (13.2) (16.3) (16.6) (14.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P-NITROBENZOIC ACID
KAPLAN-MEIER SURVIVAL CURVES
0.0% = 1
0.125% = 2
0.25% = 3
0.5% = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 1 2 3
| 4 1 1 2 12 234 4 3
| 11 2 4 24
| 1 1 1 24 4 2 2
90 + 1 1 4 23 2
| 1 113 3 3
| 11 4 3 3
| 1 214 3 3
P 80 + 114 2
E | 11 23 2 4
R | 11 3 34
C | 44
E 70 + 11 2 22
N | 1 1 23 423 44
T | 223 4 4
| 1 1 1 33 44
S 60 + 2 22 44
U | 1 1 2 23
R | 1 1 232
V | 1 1 44
I 50 + 11 44
V | 44
A | 2 32
L | 1133 4 4
40 + 1122
| 322
| 1 12 2
| 11 3
30 + 1 1
| 2 2
| 1 1
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 40 obs hidden.
P-NITROBENZOIC ACID
KAPLAN-MEIER SURVIVAL CURVES
0.0% = 1
0.125% = 2
0.25% = 3
0.5% = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 4 1
| 2 3 3 2 214 1
| 3 3 2 2 4 11 1
| 3 3 2 24 4 1 1
P 90 + 2 2 1 1
E | 33 24 4242 11
R | 3 3 422 1 1
C | 3 3 42 2 11
E 80 + 3 3 4 3 4 2 2 11
N | 3 4344 2 2 2
T | 3 3 111
| 4 33 4 11
S 70 + 4 4
U | 33 2 2
R | 3 3 411
V | 33 11
I 60 + 3 3 34
V | 1 1
A | 224 1 1
L | 33
50 + 22
| 32 2 2
|
| 3 3
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 27 obs hidden.