TDMS Study 05156-06 Pathology Tables
NTP Experiment-Test: 05156-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:11:26
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 10026-24-1
Lock Date: 07/12/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05156-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:11:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 5 3 5 6
Moribund Sacrifice 11 10 13 16
Survivors
Terminal Sacrifice 34 37 32 28
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (49) (48) (47)
Inflammation 1 (2%)
Intestine Small, Ileum (48) (48) (47) (45)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (50) (50) (50) (49)
Basophilic Focus 1 (2%)
Clear Cell Focus 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Clear Cell Focus, Multiple 1 (2%)
Cyst 1 (2%) 1 (2%)
Eosinophilic Focus 9 (18%) 7 (14%) 8 (16%) 9 (18%)
Eosinophilic Focus, Multiple 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Lymphocyte 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Chronic 6 (12%) 1 (2%) 1 (2%) 2 (4%)
Karyomegaly 4 (8%) 2 (4%) 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Necrosis, Focal 3 (6%) 1 (2%) 2 (4%) 2 (4%)
Regeneration 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Vacuolization Cytoplasmic, Diffuse 1 (2%) 1 (2%)
Oval Cell, Hyperplasia 2 (4%) 1 (2%)
Serosa, Fibrosis 1 (2%)
Mesentery (10) (12) (8) (7)
Angiectasis 1 (10%)
Hemorrhage 1 (14%)
Infiltration Cellular, Lymphocyte 1 (8%)
Inflammation, Chronic 1 (8%)
Fat, Necrosis 7 (70%) 8 (67%) 7 (88%) 5 (71%)
Pancreas (50) (50) (49) (49)
Infiltration Cellular, Lymphocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05156-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:11:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 1 (2%) 1 (2%)
Acinus, Atrophy 1 (2%) 2 (4%) 3 (6%)
Duct, Cyst 1 (2%) 2 (4%) 1 (2%)
Stomach, Forestomach (50) (50) (49) (50)
Cyst 1 (2%)
Hyperplasia, Squamous 1 (2%) 3 (6%) 1 (2%) 3 (6%)
Inflammation 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Mineralization 1 (2%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Epicardium, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Angiectasis 1 (2%)
Cyst, Focal 1 (2%)
Degeneration, Cystic, Focal 1 (2%)
Inflammation 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Capsule, Hyperplasia 1 (2%)
Pituitary Gland (48) (47) (47) (48)
Angiectasis 2 (4%) 5 (11%) 1 (2%) 2 (4%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hyperplasia 12 (25%) 1 (2%) 7 (15%) 6 (13%)
Thyroid Gland (50) (49) (49) (49)
Cyst 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation 1 (2%)
Follicular Cell, Hyperplasia 20 (40%) 17 (35%) 14 (29%) 19 (39%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05156-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:11:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (41) (40) (43) (40)
Cyst 1 (2%)
Inflammation 1 (2%) 1 (3%)
Ovary (48) (49) (49) (48)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Atrophy 2 (4%)
Cyst 9 (19%) 12 (24%) 16 (33%) 15 (31%)
Thrombosis 1 (2%)
Bilateral, Cyst 1 (2%)
Uterus (50) (50) (49) (49)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Hydrometra 3 (6%) 3 (6%) 2 (4%)
Hyperplasia, Cystic 37 (74%) 41 (82%) 38 (78%) 37 (76%)
Inflammation 2 (4%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%) 1 (2%) 1 (2%)
Cervix, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50)
Inflammation, Chronic 1 (2%)
Lymph Node (3) (6) (3) (4)
Hyperplasia, Lymphoid 1 (17%)
Iliac, Ectasia 1 (33%)
Renal, Hyperplasia, Lymphoid 1 (17%)
Lymph Node, Bronchial (30) (34) (27) (35)
Hyperplasia, Lymphoid 1 (3%) 2 (6%) 2 (7%) 3 (9%)
Infiltration Cellular, Histiocyte 1 (3%)
Lymph Node, Mandibular (37) (37) (36) (36)
Hyperplasia, Lymphoid 1 (3%)
Lymph Node, Mesenteric (46) (45) (46) (44)
Hyperplasia, Lymphoid 1 (2%) 5 (11%) 2 (4%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Lymph Node, Mediastinal (41) (36) (28) (34)
Hemorrhage 1 (3%)
Hyperplasia, Lymphoid 3 (7%) 5 (14%) 1 (4%) 3 (9%)
Spleen (50) (50) (49) (49)
Hematopoietic Cell Proliferation 3 (6%) 11 (22%) 9 (18%) 3 (6%)
Hyperplasia, Lymphoid 1 (2%) 5 (10%) 1 (2%) 2 (4%)
Thymus (41) (44) (41) (41)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05156-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:11:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (50) (50) (50)
Hyperplasia 3 (6%) 4 (8%) 2 (4%)
Skin (49) (50) (50) (50)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 2 (4%) 1 (2%) 1 (2%) 5 (10%)
Fracture 1 (2%) 1 (2%)
Maxilla, Inflammation, Chronic 1 (2%)
Skeletal Muscle (1) (2) (1)
Hemorrhage 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%)
Spinal Cord (1) (1)
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (47) (50)
Inflammation, Chronic 1 (2%)
Metaplasia, Squamous 45 (92%) 40 (85%) 50 (100%)
Lung (50) (50) (50) (50)
Hemorrhage 2 (4%) 1 (2%) 4 (8%)
Infiltration Cellular, Diffuse, Histiocyte 4 (8%)
Infiltration Cellular, Focal, Histiocyte 2 (4%) 5 (10%) 7 (14%) 10 (20%)
Inflammation, Chronic 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 3 (6%) 5 (10%)
Bronchus, Vacuolization Cytoplasmic 6 (12%) 31 (62%) 43 (86%)
Capillary, Thrombosis, Diffuse 1 (2%)
Nose (50) (50) (49) (48)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 5 (10%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05156-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:11:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Olfactory Epithelium, Atrophy 2 (4%) 12 (24%) 46 (96%)
Olfactory Epithelium, Degeneration, Hyaline 3 (6%) 1 (2%) 2 (4%) 2 (4%)
Olfactory Epithelium, Hyperplasia 30 (63%)
Olfactory Epithelium, Metaplasia 1 (2%) 1 (2%)
Respiratory Epithelium, Degeneration, Hyaline 20 (40%) 16 (32%) 14 (29%) 11 (23%)
Respiratory Epithelium, Metaplasia, Squamous 4 (8%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 1 (2%) 2 (4%)
Infarct 1 (2%)
Infiltration Cellular, Mixed Cell 3 (6%) 1 (2%) 1 (2%) 3 (6%)
Inflammation, Chronic 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Mineralization 1 (2%)
Nephropathy 5 (10%) 6 (12%) 7 (14%) 3 (6%)
Pigmentation, Hemosiderin 1 (2%)
Urinary Bladder (48) (47) (45) (46)
Edema 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05156-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:11:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 19 16 17 23
Accidently Killed 1 1
Natural Death 8 3 9 6
Survivors
Terminal Sacrifice 22 31 24 20
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (37) (41) (38) (38)
Degeneration, Hyaline 1 (3%) 1 (2%) 2 (5%)
Infiltration Cellular, Lymphocyte 1 (3%)
Intestine Small, Duodenum (45) (49) (42) (45)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis, Focal 1 (2%)
Liver (50) (50) (50) (50)
Basophilic Focus 1 (2%)
Clear Cell Focus 3 (6%) 2 (4%)
Clear Cell Focus, Multiple 1 (2%)
Cyst 1 (2%)
Eosinophilic Focus 8 (16%) 7 (14%) 9 (18%) 2 (4%)
Eosinophilic Focus, Multiple 1 (2%) 1 (2%) 3 (6%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic 33 (66%) 36 (72%) 40 (80%) 39 (78%)
Karyomegaly 39 (78%) 35 (70%) 39 (78%) 43 (86%)
Mineralization 1 (2%)
Mitotic Alteration 1 (2%)
Necrosis, Focal 3 (6%) 3 (6%) 6 (12%) 1 (2%)
Regeneration 32 (64%) 30 (60%) 35 (70%) 38 (76%)
Vacuolization Cytoplasmic, Diffuse 3 (6%) 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Hyperplasia 3 (6%) 6 (12%) 4 (8%)
Oval Cell, Hyperplasia 38 (76%) 36 (72%) 40 (80%) 44 (88%)
Mesentery (3) (4) (5) (4)
Inflammation, Chronic 1 (33%) 1 (25%)
Mineralization 1 (20%)
Artery, Fibrosis 1 (33%) 1 (25%)
Artery, Inflammation, Chronic 1 (25%)
Fat, Necrosis 1 (33%) 2 (50%) 3 (60%)
Pancreas (48) (50) (49) (50)
Acinus, Atrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05156-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:11:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (49) (50) (50) (50)
Cyst 1 (2%)
Hyperplasia, Squamous 4 (8%) 2 (4%) 2 (4%)
Inflammation 1 (2%)
Stomach, Glandular (48) (50) (50) (50)
Mineralization 1 (2%)
Tooth (1)
Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 1 (2%) 4 (8%) 2 (4%) 1 (2%)
Inflammation, Chronic 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Atrium, Thrombosis 1 (2%) 2 (4%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (49) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Hyperplasia 3 (6%) 4 (8%) 5 (10%) 2 (4%)
Inflammation 1 (2%)
Necrosis 1 (2%)
Necrosis, Diffuse 1 (2%)
Adrenal Medulla (48) (50) (49) (50)
Hyperplasia 1 (2%) 5 (10%)
Necrosis, Diffuse 1 (2%)
Thyroid Gland (49) (50) (50) (50)
Inflammation 1 (2%)
Follicular Cell, Hyperplasia 3 (6%) 17 (34%) 11 (22%) 10 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50) (50) (50)
Degeneration 1 (2%)
Granuloma Sperm 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05156-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:11:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Mineralization 2 (4%) 1 (2%)
Penis (1)
Inflammation, Chronic 1 (100%)
Preputial Gland (49) (50) (50) (49)
Cyst 1 (2%) 2 (4%) 3 (6%) 1 (2%)
Inflammation, Chronic 13 (27%) 12 (24%) 9 (18%) 5 (10%)
Inflammation, Suppurative 2 (4%) 2 (4%)
Prostate (46) (50) (44) (49)
Inflammation 2 (4%) 2 (5%) 1 (2%)
Seminal Vesicle (48) (50) (49) (49)
Inflammation, Chronic 1 (2%)
Testes (49) (50) (50) (50)
Atrophy 2 (4%) 2 (4%)
Degeneration, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (1) (2) (2)
Iliac, Hyperplasia, Lymphoid 1 (100%) 1 (50%)
Iliac, Infiltration Cellular, Histiocyte 1 (50%)
Renal, Hyperplasia, Lymphoid 1 (100%)
Lymph Node, Bronchial (21) (24) (28) (25)
Infiltration Cellular, Plasma Cell 1 (4%)
Infiltration Cellular, Histiocyte 1 (5%) 1 (4%)
Lymph Node, Mesenteric (49) (48) (43) (47)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 2 (4%) 2 (4%) 4 (9%) 3 (6%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%) 2 (5%) 2 (4%)
Lymph Node, Mediastinal (43) (28) (31) (35)
Hyperplasia, Lymphoid 1 (4%) 4 (13%)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (4%)
Infiltration Cellular, Histiocyte 2 (5%) 1 (3%)
Inflammation, Chronic 1 (3%) 1 (3%)
Spleen (47) (50) (49) (50)
Angiectasis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 10 (21%) 6 (12%) 6 (12%) 14 (28%)
Hyperplasia, Lymphoid 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (50) (49) (49)
Inflammation, Chronic 1 (2%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05156-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:11:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Epidermis, Hyperplasia 1 (2%) 1 (2%)
Prepuce, Inflammation, Chronic 1 (2%)
Prepuce, Ulcer 4 (8%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fracture 1 (2%)
Skeletal Muscle (1) (2)
Inflammation, Chronic, Focal 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (48) (49) (48) (49)
Foreign Body 1 (2%)
Metaplasia, Squamous 37 (76%) 48 (100%) 44 (90%)
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Diffuse, Histiocyte 1 (2%) 2 (4%) 4 (8%) 10 (20%)
Infiltration Cellular, Focal, Histiocyte 10 (20%) 5 (10%) 8 (16%) 17 (34%)
Inflammation, Chronic 1 (2%) 1 (2%) 3 (6%)
Alveolar Epithelium, Hyperplasia 4 (8%) 4 (8%) 4 (8%)
Alveolar Epithelium, Goblet Cell, Metaplasia,
Focal 1 (2%)
Artery, Thrombosis 1 (2%)
Bronchus, Hyperplasia 1 (2%)
Bronchus, Vacuolization Cytoplasmic 18 (36%) 34 (68%) 38 (76%)
Nose (50) (50) (48) (49)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%) 6 (12%)
Olfactory Epithelium, Atrophy 29 (60%) 48 (98%)
Olfactory Epithelium, Degeneration, Hyaline 2 (4%) 2 (4%)
Olfactory Epithelium, Hyperplasia 10 (20%)
Olfactory Epithelium, Metaplasia 2 (4%)
Respiratory Epithelium, Degeneration, Hyaline 1 (2%)
Trachea (49) (50) (50) (50)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05156-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:11:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (1)
Degeneration 1 (100%) 1 (100%)
Hemorrhage 1 (100%)
Inflammation 1 (100%)
Cornea, Inflammation 1 (100%)
Harderian Gland (4) (4) (4) (6)
Inflammation, Acute 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Infiltration Cellular, Mixed Cell 5 (10%) 1 (2%) 5 (10%) 3 (6%)
Inflammation, Chronic 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Mineralization 1 (2%)
Nephropathy 11 (22%) 13 (26%) 7 (14%) 9 (18%)
Glomerulus, Amyloid Deposition 1 (2%) 2 (4%)
Medulla, Inflammation, Chronic 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (46) (49) (45) (48)
Inflammation 3 (7%) 3 (7%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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