TDMS Study 05156-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest COBALT SULFATE HEPTAHYDRATE DATE: 07/03/96
EXPERIMENT: 05156 TEST: 06 TIME: 11:13:03
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-05287 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61530B
PATHOLOGIST: MELLICK, P. CAS: 10026-24-1
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest COBALT SULFATE HEPTAHYDRATE DATE: 07/03/96
EXPERIMENT: 05156 TEST: 06 TIME: 11:13:03
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05287 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61530B
PATHOLOGIST: MELLICK, P. CAS: 10026-24-1
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest COBALT SULFATE HEPTAHYDRATE DATE: 07/03/96
EXPERIMENT: 05156 TEST: 06 TIME: 11:13:03
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05287 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61530B
PATHOLOGIST: MELLICK, P. CAS: 10026-24-1
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 1 COBALT SULFATE HEPTAHYDRATE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hemangiosarcoma
Hepatoblastoma
Hepatocellular Adenoma
Hepatocellular Carcinoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Hemangiosarcoma
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Skin Sarcoma
Thyroid Gland: Follicular Cell
Adenoma
All Organs Histiocytic Sarcoma
====================================================================================================
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 2/50 (4%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 5.9% 0.0% 5.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 1/31 (3%) 0/24 (0%) 1/20 (5%) | 0/34 (0%) 0/37 (0%) 0/32 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- 687 --- 733 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.553 P=0.320 (e) P=0.481 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.541 P=0.267 (e) P=0.481 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.560 P=0.275 (e) P=0.481 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.625 | (e) |
|FISHER EXACT | P=0.253 (e) P=0.505 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 2/50 (4%) 1/50 (2%) | 2/50 (4%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 13.2% 6.5% 8.3% 4.5% | 5.9% 5.4% 0.0% 3.6% |
|TERMINAL (d) | 1/22 (5%) 2/31 (6%) 2/24 (8%) 0/20 (0%) | 2/34 (6%) 2/37 (5%) 0/32 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 600 733 (T) 733 (T) 686 | 734 (T) 734 (T) --- 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.270N P=0.221N P=0.306N P=0.239N | P=0.459N P=0.665N P=0.252N P=0.568N |
|INCIDENTAL TUMOR | P=0.235N P=0.308N P=0.317N P=0.242N | P=0.459N P=0.665N P=0.252N P=0.568N |
|LOGISTIC REGRESSION | P=0.229N P=0.307N P=0.324N P=0.192N | P=0.459N P=0.665N P=0.252N P=0.568N |
|COCHRAN-ARMITAGE | P=0.185N | P=0.382N |
|FISHER EXACT | P=0.339N P=0.339N P=0.181N | P=0.691N P=0.247N P=0.500N |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 8/50 (16%) 7/50 (14%) | 1/50 (2%) 0/50 (0%) 3/50 (6%) 0/49 (0%) |
|ADJUSTED (b) | 9.1% 11.5% 23.5% 25.0% | 2.9% 0.0% 7.3% 0.0% |
|TERMINAL (d) | 2/22 (9%) 2/31 (6%) 2/24 (8%) 3/20 (15%) | 1/34 (3%) 0/37 (0%) 1/32 (3%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 685 523 502 | 734 (T) --- 524 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.036 * P=0.500 P=0.071 P=0.064 | P=0.499N P=0.483N P=0.298 P=0.539N |
|INCIDENTAL TUMOR | P=0.088 P=0.431 P=0.051 P=0.087 | P=0.364N P=0.483N P=0.319 P=0.539N |
|LOGISTIC REGRESSION | P=0.078 P=0.441 P=0.050 * P=0.069 | P=0.431N P=0.483N P=0.318 P=0.539N |
|COCHRAN-ARMITAGE | P=0.096 | P=0.455N |
|FISHER EXACT | P=0.339 P=0.046 * P=0.080 | P=0.500N P=0.309 P=0.505N |
|=================================================================================================================================|
| |
|Liver |
| Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 0/50 (0%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/49 (0%) |
|ADJUSTED (b) | 11.8% 0.0% 7.6% 10.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 0/31 (0%) 1/24 (4%) 2/20 (10%) | 0/34 (0%) 0/37 (0%) 0/32 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 533 --- 705 733 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.596 P=0.043N* P=0.313N P=0.390N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.582N P=0.103N P=0.346N P=0.353N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.567N P=0.095N P=0.342N P=0.345N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.549N | (e) |
|FISHER EXACT | P=0.059N P=0.339N P=0.339N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 22/50 (44%) 21/50 (42%) 25/50 (50%) 13/50 (26%) | 8/50 (16%) 10/50 (20%) 13/50 (26%) 12/49 (24%) |
|ADJUSTED (b) | 71.4% 57.5% 74.0% 42.3% | 22.9% 25.0% 34.0% 35.3% |
|TERMINAL (d) | 14/22 (64%) 16/31 (52%) 16/24 (67%) 5/20 (25%) | 7/34 (21%) 8/37 (22%) 8/32 (25%) 8/28 (29%) |
|FIRST INCIDENCE (DAYS) | 470 614 440 533 | 713 593 622 539 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.192N P=0.102N P=0.473 P=0.123N | P=0.103 P=0.480 P=0.150 P=0.128 |
|INCIDENTAL TUMOR | P=0.044N* P=0.265N P=0.380 P=0.065N | P=0.147 P=0.451 P=0.189 P=0.159 |
|LOGISTIC REGRESSION | P=0.061N P=0.290N P=0.389 P=0.067N | P=0.174 P=0.466 P=0.152 P=0.180 |
|COCHRAN-ARMITAGE | P=0.026N* | P=0.221 |
|FISHER EXACT | P=0.500N P=0.344 P=0.046N* | P=0.398 P=0.163 P=0.212 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/50 (46%) 33/50 (66%) 30/50 (60%) 30/50 (60%) | 12/50 (24%) 9/50 (18%) 16/50 (32%) 4/49 (8%) |
|ADJUSTED (b) | 60.8% 69.5% 66.5% 71.2% | 31.7% 22.7% 40.5% 11.8% |
|TERMINAL (d) | 9/22 (41%) 17/31 (55%) 10/24 (42%) 9/20 (45%) | 9/34 (26%) 7/37 (19%) 9/32 (28%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 482 460 440 502 | 609 666 640 667 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.074 P=0.398 P=0.262 P=0.094 | P=0.094N P=0.240N P=0.235 P=0.063N |
|INCIDENTAL TUMOR | P=0.520 P=0.014 * P=0.090 P=0.173 | P=0.049N* P=0.290N P=0.263 P=0.039N* |
|LOGISTIC REGRESSION | P=0.471 P=0.017 * P=0.097 P=0.143 | P=0.051N P=0.258N P=0.238 P=0.037N* |
|COCHRAN-ARMITAGE | P=0.303 | P=0.036N* |
|FISHER EXACT | P=0.035 * P=0.115 P=0.115 | P=0.312N P=0.252 P=0.030N* |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 27/50 (54%) 33/50 (66%) 31/50 (62%) 31/50 (62%) | 12/50 (24%) 9/50 (18%) 16/50 (32%) 4/49 (8%) |
|ADJUSTED (b) | 66.6% 69.5% 67.7% 73.8% | 31.7% 22.7% 40.5% 11.8% |
|TERMINAL (d) | 10/22 (45%) 17/31 (55%) 10/24 (42%) 10/20 (50%) | 9/34 (26%) 7/37 (19%) 9/32 (28%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 482 460 440 502 | 609 666 640 667 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.106 P=0.458N P=0.436 P=0.190 | P=0.094N P=0.240N P=0.235 P=0.063N |
|INCIDENTAL TUMOR | P=0.458N P=0.064 P=0.223 P=0.365 | P=0.049N* P=0.290N P=0.263 P=0.039N* |
|LOGISTIC REGRESSION | P=0.500N P=0.062 P=0.221 P=0.328 | P=0.051N P=0.258N P=0.238 P=0.037N* |
|COCHRAN-ARMITAGE | P=0.414 | P=0.036N* |
|FISHER EXACT | P=0.154 P=0.272 P=0.272 | P=0.312N P=0.252 P=0.030N* |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 38/50 (76%) 41/50 (82%) 43/50 (86%) 38/50 (76%) | 18/50 (36%) 18/50 (36%) 24/50 (48%) 16/49 (33%) |
|ADJUSTED (b) | 89.8% 85.2% 93.2% 83.9% | 48.1% 43.3% 56.7% 43.8% |
|TERMINAL (d) | 18/22 (82%) 24/31 (77%) 21/24 (88%) 13/20 (65%) | 15/34 (44%) 14/37 (38%) 14/32 (44%) 9/28 (32%) |
|FIRST INCIDENCE (DAYS) | 470 460 440 502 | 609 593 622 539 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.134 P=0.161N P=0.425 P=0.338 | P=0.444 P=0.451N P=0.145 P=0.530 |
|INCIDENTAL TUMOR | P=0.255N P=0.273 P=0.145 P=0.482N | P=0.523N P=0.549N P=0.150 P=0.560N |
|LOGISTIC REGRESSION | P=0.375N P=0.284 P=0.155 P=0.591 | P=0.474N P=0.488N P=0.137 P=0.506N |
|COCHRAN-ARMITAGE | P=0.399N | P=0.374N |
|FISHER EXACT | P=0.312 P=0.154 P=0.592N | P=0.582N P=0.156 P=0.445N |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 40/50 (80%) 41/50 (82%) 44/50 (88%) 39/50 (78%) | 18/50 (36%) 18/50 (36%) 24/50 (48%) 16/49 (33%) |
|ADJUSTED (b) | 90.3% 85.2% 93.5% 86.2% | 48.1% 43.3% 56.7% 43.8% |
|TERMINAL (d) | 18/22 (82%) 24/31 (77%) 21/24 (88%) 14/20 (70%) | 15/34 (44%) 14/37 (38%) 14/32 (44%) 9/28 (32%) |
|FIRST INCIDENCE (DAYS) | 470 460 440 502 | 609 593 622 539 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.134 P=0.100N P=0.488 P=0.383 | P=0.444 P=0.451N P=0.145 P=0.530 |
|INCIDENTAL TUMOR | P=0.250N P=0.406 P=0.193 P=0.414N | P=0.523N P=0.549N P=0.150 P=0.560N |
|LOGISTIC REGRESSION | P=0.340N P=0.423 P=0.204 P=0.494N | P=0.474N P=0.488N P=0.137 P=0.506N |
|COCHRAN-ARMITAGE | P=0.376N | P=0.374N |
|FISHER EXACT | P=0.500 P=0.207 P=0.500N | P=0.582N P=0.156 P=0.445N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocholangiocarcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/49 (0%) |
|ADJUSTED (b) | 2.3% 0.0% 0.0% 0.0% | 5.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/31 (0%) 0/24 (0%) 0/20 (0%) | 0/34 (0%) 0/37 (0%) 0/32 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 541 --- --- --- | 620 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.484N P=0.483N P=0.500N P=0.505N | P=0.259N P=0.222N P=0.240N P=0.257N |
|INCIDENTAL TUMOR | P=0.426N P=0.695N P=0.557N P=0.500N | P=0.251N P=0.302N P=0.249N P=0.249N |
|LOGISTIC REGRESSION | P=0.388N P=0.645N P=0.524N P=0.446N | P=0.234N P=0.269N P=0.229N P=0.233N |
|COCHRAN-ARMITAGE | P=0.474N | P=0.245N |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | P=0.247N P=0.247N P=0.253N |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 12/50 (24%) 13/50 (26%) 18/50 (36%) | 3/50 (6%) 6/50 (12%) 9/50 (18%) 10/50 (20%) |
|ADJUSTED (b) | 30.4% 30.9% 41.1% 54.6% | 8.8% 15.0% 25.2% 32.8% |
|TERMINAL (d) | 4/22 (18%) 6/31 (19%) 7/24 (29%) 7/20 (35%) | 3/34 (9%) 4/37 (11%) 6/32 (19%) 8/28 (29%) |
|FIRST INCIDENCE (DAYS) | 600 460 548 524 | 734 (T) 664 649 706 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005 ** P=0.589 P=0.308 P=0.024 * | P=0.014 * P=0.297 P=0.056 P=0.016 * |
|INCIDENTAL TUMOR | P=0.018 * P=0.332 P=0.271 P=0.026 * | P=0.026 * P=0.336 P=0.080 P=0.025 * |
|LOGISTIC REGRESSION | P=0.018 * P=0.353 P=0.256 P=0.027 * | P=0.024 * P=0.287 P=0.057 P=0.024 * |
|COCHRAN-ARMITAGE | P=0.029 * | P=0.045 * |
|FISHER EXACT | P=0.312 P=0.235 P=0.035 * | P=0.243 P=0.061 P=0.036 * |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 5/50 (10%) 7/50 (14%) 11/50 (22%) | 1/50 (2%) 1/50 (2%) 4/50 (8%) 9/50 (18%) |
|ADJUSTED (b) | 13.2% 16.1% 25.3% 43.7% | 2.9% 2.7% 9.2% 25.3% |
|TERMINAL (d) | 2/22 (9%) 5/31 (16%) 4/24 (17%) 7/20 (35%) | 1/34 (3%) 1/37 (3%) 1/32 (3%) 4/28 (14%) |
|FIRST INCIDENCE (DAYS) | 449 733 (T) 687 552 | 734 (T) 734 (T) 495 536 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.004 ** P=0.603N P=0.313 P=0.031 * | P<0.001 ** P=0.743N P=0.173 P=0.007 ** |
|INCIDENTAL TUMOR | P=0.008 ** P=0.572 P=0.282 P=0.043 * | P=0.001 ** P=0.743N P=0.142 P=0.016 * |
|LOGISTIC REGRESSION | P=0.006 ** P=0.528 P=0.273 P=0.033 * | P<0.001 ** P=0.743N P=0.201 P=0.009 ** |
|COCHRAN-ARMITAGE | P=0.021 * | P<0.001 ** |
|FISHER EXACT | P=0.500 P=0.262 P=0.045 * | P=0.753N P=0.181 P=0.008 ** |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/50 (22%) 14/50 (28%) 19/50 (38%) 28/50 (56%) | 4/50 (8%) 7/50 (14%) 13/50 (26%) 18/50 (36%) |
|ADJUSTED (b) | 35.5% 36.5% 56.5% 78.8% | 11.8% 17.5% 32.6% 50.2% |
|TERMINAL (d) | 5/22 (23%) 8/31 (26%) 10/24 (42%) 13/20 (65%) | 4/34 (12%) 5/37 (14%) 7/32 (22%) 11/28 (39%) |
|FIRST INCIDENCE (DAYS) | 449 460 548 524 | 734 (T) 664 495 536 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.544N P=0.122 P<0.001 ** | P<0.001 ** P=0.322 P=0.016 * P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.347 P=0.081 P<0.001 ** | P<0.001 ** P=0.360 P=0.020 * P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.345 P=0.071 P<0.001 ** | P<0.001 ** P=0.318 P=0.016 * P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.322 P=0.063 P<0.001 ** | P=0.262 P=0.016 * P<0.001 ** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.4% 2.7% 3.1% 6.3% |
|TERMINAL (d) | 0/22 (0%) 0/31 (0%) 0/24 (0%) 0/20 (0%) | 0/34 (0%) 1/37 (3%) 1/32 (3%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 643 734 (T) 734 (T) 692 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.298 P=0.736N P=0.756 P=0.466 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.316 P=0.635 P=0.678 P=0.468 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.343 P=0.753 P=0.763N P=0.498 |
|COCHRAN-ARMITAGE | (e) | P=0.360 |
|FISHER EXACT | (e) (e) (e) | P=0.753N P=0.753N P=0.500 |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.4% 2.7% 3.1% 6.3% |
|TERMINAL (d) | 0/22 (0%) 0/31 (0%) 0/24 (0%) 0/20 (0%) | 0/34 (0%) 1/37 (3%) 1/32 (3%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 643 734 (T) 734 (T) 692 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.298 P=0.736N P=0.756 P=0.466 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.316 P=0.635 P=0.678 P=0.468 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.343 P=0.753 P=0.763N P=0.498 |
|COCHRAN-ARMITAGE | (e) | P=0.360 |
|FISHER EXACT | (e) (e) (e) | P=0.753N P=0.753N P=0.500 |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/48 (4%) 3/49 (6%) 3/49 (6%) 3/48 (6%) |
|ADJUSTED (b) | | 6.3% 8.3% 9.4% 10.7% |
|TERMINAL (d) | | 2/32 (6%) 3/36 (8%) 3/32 (9%) 3/28 (11%) |
|FIRST INCIDENCE (DAYS) | | 734 (T) 734 (T) 734 (T) 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.390 P=0.554 P=0.500 P=0.439 |
|INCIDENTAL TUMOR | | P=0.390 P=0.554 P=0.500 P=0.439 |
|LOGISTIC REGRESSION | | P=0.390 P=0.554 P=0.500 P=0.439 |
|COCHRAN-ARMITAGE | | P=0.487 |
|FISHER EXACT | | P=0.510 P=0.510 P=0.500 |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/48 (0%) 0/50 (0%) 0/48 (0%) 0/47 (0%) | 11/48 (23%) 8/47 (17%) 7/47 (15%) 8/48 (17%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 30.0% 22.2% 20.7% 24.7% |
|TERMINAL (d) | 0/22 (0%) 0/31 (0%) 0/23 (0%) 0/20 (0%) | 8/33 (24%) 8/36 (22%) 5/30 (17%) 5/28 (18%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 596 734 (T) 659 675 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.538N P=0.236N P=0.271N P=0.426N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.440N P=0.265N P=0.222N P=0.309N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.430N P=0.255N P=0.248N P=0.343N |
|COCHRAN-ARMITAGE | (e) | P=0.355N |
|FISHER EXACT | (e) (e) (e) | P=0.323N P=0.231N P=0.305N |
|=================================================================================================================================|
| |
|Skin |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 3.0% 3.2% 0.0% 7.3% | 0.0% 0.0% 3.1% 0.0% |
|TERMINAL (d) | 0/22 (0%) 1/31 (3%) 0/24 (0%) 1/20 (5%) | 0/34 (0%) 0/37 (0%) 1/32 (3%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 651 733 (T) --- 555 | --- --- 734 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.262 P=0.697N P=0.488N P=0.459 | P=0.807 (e) P=0.488 (e) |
|INCIDENTAL TUMOR | P=0.333 P=0.733N P=0.484N P=0.498 | P=0.807 (e) P=0.488 (e) |
|LOGISTIC REGRESSION | P=0.330 P=0.750N P=0.503N P=0.505 | P=0.807 (e) P=0.488 (e) |
|COCHRAN-ARMITAGE | P=0.333 | P=0.786N |
|FISHER EXACT | P=0.753N P=0.500N P=0.500 | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 6/50 (12%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.4% 0.0% 0.0% 0.0% | 16.0% 4.3% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/31 (0%) 0/24 (0%) 0/20 (0%) | 4/34 (12%) 0/37 (0%) 0/32 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 575 --- --- --- | 225 593 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.513N P=0.473N P=0.505N P=0.537N | P=0.022N* P=0.116N P=0.022N* P=0.029N* |
|INCIDENTAL TUMOR | P=0.344N P=0.594N P=0.527N P=0.375N | P=0.015N* P=0.203N P=0.016N* P=0.020N* |
|LOGISTIC REGRESSION | P=0.412N P=0.611N P=0.518N P=0.464N | P=0.012N* P=0.210N P=0.014N* P=0.014N* |
|COCHRAN-ARMITAGE | P=0.474N | P=0.015N* |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | P=0.134N P=0.013N* P=0.013N* |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/47 (2%) 3/50 (6%) 1/49 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/49 (0%) 0/49 (0%) |
|ADJUSTED (b) | 3.0% 8.5% 3.1% 10.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 1/31 (3%) 0/24 (0%) 2/20 (10%) | 0/34 (0%) 0/37 (0%) 0/32 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 651 685 681 733 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.454 P=0.419 P=0.739N P=0.450 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.431 P=0.333 P=0.746N P=0.426 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.524 P=0.337 P=0.754N P=0.465 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.596 | (e) |
|FISHER EXACT | P=0.332 P=0.742N P=0.523 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 5.7% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 1/31 (3%) 0/24 (0%) 0/20 (0%) | 0/34 (0%) 0/37 (0%) 0/32 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- 666 --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.426N P=0.308 (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.439N P=0.267 (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.399N P=0.260 (e) (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.369N | (e) |
|FISHER EXACT | P=0.247 (e) (e) | (e) (e) (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) 0/50 (0%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 5.7% 4.2% 0.0% | 2.9% 2.7% 0.0% 3.6% |
|TERMINAL (d) | 0/22 (0%) 1/31 (3%) 1/24 (4%) 0/20 (0%) | 1/34 (3%) 1/37 (3%) 0/32 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | --- 666 733 (T) --- | 734 (T) 734 (T) --- 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.447N P=0.308 P=0.517 (e) | P=0.625 P=0.743N P=0.512N P=0.718 |
|INCIDENTAL TUMOR | P=0.459N P=0.267 P=0.517 (e) | P=0.625 P=0.743N P=0.512N P=0.718 |
|LOGISTIC REGRESSION | P=0.431N P=0.260 P=0.517 (e) | P=0.625 P=0.743N P=0.512N P=0.718 |
|COCHRAN-ARMITAGE | P=0.378N | P=0.677 |
|FISHER EXACT | P=0.247 P=0.500 (e) | P=0.753N P=0.500N P=0.753N |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) | 3/50 (6%) 0/49 (0%) 0/49 (0%) 5/49 (10%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 5.0% | 8.0% 0.0% 0.0% 16.7% |
|TERMINAL (d) | 0/22 (0%) 0/31 (0%) 0/24 (0%) 1/20 (5%) | 2/34 (6%) 0/36 (0%) 0/32 (0%) 4/28 (14%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 733 (T) | 619 --- --- 686 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.172 (e) (e) P=0.481 | P=0.026 * P=0.113N P=0.130N P=0.274 |
|INCIDENTAL TUMOR | P=0.172 (e) (e) P=0.481 | P=0.026 * P=0.184N P=0.171N P=0.258 |
|LOGISTIC REGRESSION | P=0.172 (e) (e) P=0.481 | P=0.038 * P=0.126N P=0.125N P=0.323 |
|COCHRAN-ARMITAGE | P=0.215 | P=0.046 * |
|FISHER EXACT | (e) (e) P=0.505 | P=0.125N P=0.125N P=0.346 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 1/50 (2%) 0/49 (0%) 2/49 (4%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.2% 0.0% | 2.9% 0.0% 6.3% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/31 (0%) 1/24 (4%) 0/20 (0%) | 0/34 (0%) 0/36 (0%) 2/32 (6%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 733 (T) --- | 713 --- 734 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.809 (e) P=0.517 (e) | P=0.509N P=0.473N P=0.483 P=0.518N |
|INCIDENTAL TUMOR | P=0.809 (e) P=0.517 (e) | P=0.460N P=0.398N P=0.532 P=0.379N |
|LOGISTIC REGRESSION | P=0.809 (e) P=0.517 (e) | P=0.483N P=0.496N P=0.490 P=0.512N |
|COCHRAN-ARMITAGE | P=0.785N | P=0.459N |
|FISHER EXACT | (e) P=0.505 (e) | P=0.505N P=0.492 P=0.505N |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) | 4/50 (8%) 0/49 (0%) 2/49 (4%) 5/49 (10%) |
|ADJUSTED (b) | 0.0% 0.0% 4.2% 5.0% | 10.6% 0.0% 6.3% 16.7% |
|TERMINAL (d) | 0/22 (0%) 0/31 (0%) 1/24 (4%) 1/20 (5%) | 2/34 (6%) 0/36 (0%) 2/32 (6%) 4/28 (14%) |
|FIRST INCIDENCE (DAYS) | --- --- 733 (T) 733 (T) | 619 --- 734 (T) 686 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.243 (e) P=0.517 P=0.481 | P=0.081 P=0.056N P=0.360N P=0.407 |
|INCIDENTAL TUMOR | P=0.243 (e) P=0.517 P=0.481 | P=0.092 P=0.075N P=0.377N P=0.437 |
|LOGISTIC REGRESSION | P=0.243 (e) P=0.517 P=0.481 | P=0.108 P=0.065N P=0.351N P=0.462 |
|COCHRAN-ARMITAGE | P=0.305 | P=0.130 |
|FISHER EXACT | (e) P=0.505 P=0.505 | P=0.061N P=0.349N P=0.487 |
|=================================================================================================================================|
| |
|Uterus |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 1/50 (2%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | | 0.0% 2.7% 5.9% 0.0% |
|TERMINAL (d) | | 0/34 (0%) 1/37 (3%) 1/32 (3%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 734 (T) 709 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.569N P=0.517 P=0.233 (e) |
|INCIDENTAL TUMOR | | P=0.523N P=0.517 P=0.287 (e) |
|LOGISTIC REGRESSION | | P=0.545N P=0.517 P=0.235 (e) |
|COCHRAN-ARMITAGE | | P=0.515N |
|FISHER EXACT | | P=0.500 P=0.247 (e) |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | | 0.0% 5.3% 0.0% 0.0% |
|TERMINAL (d) | | 0/34 (0%) 1/37 (3%) 0/32 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 727 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.412N P=0.262 (e) (e) |
|INCIDENTAL TUMOR | | P=0.354N P=0.305 (e) (e) |
|LOGISTIC REGRESSION | | P=0.393N P=0.262 (e) (e) |
|COCHRAN-ARMITAGE | | P=0.369N |
|FISHER EXACT | | P=0.247 (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 9.1% 0.0% 0.0% 0.0% | 0.0% 2.7% 5.9% 3.6% |
|TERMINAL (d) | 2/22 (9%) 0/31 (0%) 0/24 (0%) 0/20 (0%) | 0/34 (0%) 1/37 (3%) 1/32 (3%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- --- --- | --- 734 (T) 709 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.275N P=0.166N P=0.218N P=0.258N | P=0.435 P=0.517 P=0.233 P=0.461 |
|INCIDENTAL TUMOR | P=0.275N P=0.166N P=0.218N P=0.258N | P=0.474 P=0.517 P=0.287 P=0.461 |
|LOGISTIC REGRESSION | P=0.275N P=0.166N P=0.218N P=0.258N | P=0.464 P=0.517 P=0.235 P=0.461 |
|COCHRAN-ARMITAGE | P=0.242N | P=0.500 |
|FISHER EXACT | P=0.247N P=0.247N P=0.247N | P=0.500 P=0.247 P=0.500 |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 6/50 (12%) 8/50 (16%) 9/50 (18%) | 1/50 (2%) 2/50 (4%) 4/50 (8%) 0/50 (0%) |
|ADJUSTED (b) | 11.8% 17.6% 23.5% 31.1% | 2.9% 4.8% 10.3% 0.0% |
|TERMINAL (d) | 2/22 (9%) 4/31 (13%) 2/24 (8%) 4/20 (20%) | 1/34 (3%) 1/37 (3%) 2/32 (6%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 651 685 523 502 | 734 (T) 652 524 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.025 * P=0.423 P=0.139 P=0.047 * | P=0.321N P=0.536 P=0.173 P=0.539N |
|INCIDENTAL TUMOR | P=0.070 P=0.347 P=0.107 P=0.065 | P=0.215N P=0.578 P=0.183 P=0.539N |
|LOGISTIC REGRESSION | P=0.061 P=0.344 P=0.103 P=0.054 | P=0.250N P=0.505 P=0.184 P=0.539N |
|COCHRAN-ARMITAGE | P=0.079 | P=0.263N |
|FISHER EXACT | P=0.243 P=0.100 P=0.061 | P=0.500 P=0.181 P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 6/50 (12%) 8/50 (16%) 9/50 (18%) | 1/50 (2%) 3/50 (6%) 6/50 (12%) 1/50 (2%) |
|ADJUSTED (b) | 20.7% 17.6% 23.5% 31.1% | 2.9% 7.5% 15.8% 3.6% |
|TERMINAL (d) | 4/22 (18%) 4/31 (13%) 2/24 (8%) 4/20 (20%) | 1/34 (3%) 2/37 (5%) 3/32 (9%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 651 685 523 502 | 734 (T) 652 524 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.060 P=0.528N P=0.338 P=0.149 | P=0.499N P=0.342 P=0.057 P=0.718 |
|INCIDENTAL TUMOR | P=0.137 P=0.599N P=0.293 P=0.192 | P=0.370N P=0.375 P=0.071 P=0.718 |
|LOGISTIC REGRESSION | P=0.120 P=0.605N P=0.289 P=0.162 | P=0.406N P=0.319 P=0.059 P=0.718 |
|COCHRAN-ARMITAGE | P=0.160 | P=0.403N |
|FISHER EXACT | P=0.500 P=0.277 P=0.194 | P=0.309 P=0.056 P=0.753N |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 1/50 (2%) | 3/50 (6%) 2/50 (4%) 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 4.2% 0.0% 0.0% 4.5% | 7.7% 4.8% 0.0% 7.9% |
|TERMINAL (d) | 0/22 (0%) 0/31 (0%) 0/24 (0%) 0/20 (0%) | 0/34 (0%) 1/37 (3%) 0/32 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 711 --- --- 686 | 656 649 --- 639 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.469 P=0.436N P=0.500N P=0.722 | P=0.456 P=0.452N P=0.126N P=0.644 |
|INCIDENTAL TUMOR | P=0.426 P=0.517N P=0.484N P=0.640 | P=0.594 P=0.301N P=0.039N* P=0.474N |
|LOGISTIC REGRESSION | P=0.502 P=0.463N P=0.489N P=0.738 | P=0.496 P=0.396N P=0.118N P=0.644N |
|COCHRAN-ARMITAGE | P=0.536 | P=0.500 |
|FISHER EXACT | P=0.500N P=0.500N P=0.753N | P=0.500N P=0.121N P=0.661N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 1/50 (2%) 0/50 (0%) | 4/50 (8%) 7/50 (14%) 7/50 (14%) 5/50 (10%) |
|ADJUSTED (b) | 3.3% 3.1% 2.9% 0.0% | 10.8% 16.8% 19.8% 13.4% |
|TERMINAL (d) | 0/22 (0%) 0/31 (0%) 0/24 (0%) 0/20 (0%) | 3/34 (9%) 3/37 (8%) 5/32 (16%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 676 726 652 --- | 583 666 649 356 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.393N P=0.694N P=0.743N P=0.553N | P=0.492 P=0.327 P=0.240 P=0.429 |
|INCIDENTAL TUMOR | P=0.430N P=0.746 P=0.747N P=0.607N | P=0.526N P=0.329 P=0.253 P=0.435 |
|LOGISTIC REGRESSION | P=0.339N P=0.738N P=0.762 P=0.512N | P=0.524N P=0.267 P=0.255 P=0.527 |
|COCHRAN-ARMITAGE | P=0.323N | P=0.528N |
|FISHER EXACT | P=0.753N P=0.753N P=0.500N | P=0.262 P=0.262 P=0.500 |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 30/50 (60%) 30/50 (60%) 30/50 (60%) 27/50 (54%) | 25/50 (50%) 32/50 (64%) 27/50 (54%) 27/50 (54%) |
|ADJUSTED (b) | 84.8% 74.3% 77.7% 73.0% | 65.5% 76.0% 68.9% 72.1% |
|TERMINAL (d) | 17/22 (77%) 21/31 (68%) 16/24 (67%) 11/20 (55%) | 21/34 (62%) 27/37 (73%) 20/32 (63%) 18/28 (64%) |
|FIRST INCIDENCE (DAYS) | 470 460 440 524 | 596 593 622 539 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.276 P=0.086N P=0.430N P=0.538 | P=0.185 P=0.242 P=0.336 P=0.163 |
|INCIDENTAL TUMOR | P=0.359N P=0.338N P=0.530N P=0.430N | P=0.332 P=0.176 P=0.395 P=0.257 |
|LOGISTIC REGRESSION | P=0.437N P=0.353N P=0.542N P=0.444N | P=0.408 P=0.220 P=0.390 P=0.305 |
|COCHRAN-ARMITAGE | P=0.279N | P=0.465N |
|FISHER EXACT | P=0.581N P=0.581N P=0.343N | P=0.113 P=0.421 P=0.421 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 33/50 (66%) 39/50 (78%) 41/50 (82%) 38/50 (76%) | 27/50 (54%) 22/50 (44%) 31/50 (62%) 21/50 (42%) |
|ADJUSTED (b) | 73.8% 79.4% 85.1% 87.8% | 58.5% 47.6% 68.3% 49.5% |
|TERMINAL (d) | 11/22 (50%) 21/31 (68%) 17/24 (71%) 15/20 (75%) | 15/34 (44%) 13/37 (35%) 18/32 (56%) 7/28 (25%) |
|FIRST INCIDENCE (DAYS) | 449 460 440 502 | 225 593 495 356 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.053 P=0.374N P=0.270 P=0.141 | P=0.530N P=0.154N P=0.268 P=0.368N |
|INCIDENTAL TUMOR | P=0.431 P=0.045 * P=0.040 * P=0.224 | P=0.161N P=0.241N P=0.245 P=0.111N |
|LOGISTIC REGRESSION | P=0.412 P=0.042 * P=0.037 * P=0.205 | P=0.187N P=0.266N P=0.276 P=0.147N |
|COCHRAN-ARMITAGE | P=0.318 | P=0.199N |
|FISHER EXACT | P=0.133 P=0.055 P=0.189 | P=0.212N P=0.272 P=0.158N |
|=================================================================================================================================|
DATE: 07/03/96 EXPERIMENT: 05156 TEST: 06 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1 COBALT SULFATE HEPTAHYDRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.3 1.0 3.0 | CONTROL 0.3 1.0 3.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 48/50 (96%) 47/50 (94%) 46/50 (92%) | 42/50 (84%) 41/50 (82%) 43/50 (86%) 39/50 (78%) |
|ADJUSTED (b) | 100.0% 96.0% 95.9% 95.8% | 89.3% 87.2% 91.4% 84.8% |
|TERMINAL (d) | 22/22 (100%) 29/31 (94%) 22/24 (92%) 18/20 (90%) | 29/34 (85%) 31/37 (84%) 28/32 (88%) 21/28 (75%) |
|FIRST INCIDENCE (DAYS) | 449 460 440 502 | 225 593 495 356 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.114 P=0.028N* P=0.283N P=0.435 | P=0.213 P=0.255N P=0.387 P=0.395 |
|INCIDENTAL TUMOR | P=0.160N P=0.526N P=0.286N P=0.205N | P=0.507N P=0.473N P=0.400 P=0.542N |
|LOGISTIC REGRESSION | P=0.238N P=0.527N P=0.297N P=0.279N | P=0.366N P=0.422N P=0.459 P=0.353N |
|COCHRAN-ARMITAGE | P=0.143N | P=0.258N |
|FISHER EXACT | P=0.500N P=0.309N P=0.181N | P=0.500N P=0.500 P=0.306N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).