TDMS Study 05156-06 Pathology Tables
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 10026-24-1
Lock Date: 07/12/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 1| 3| 5| 3| 9| 3| 3| 7| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 9|
| 5| 9| 6| 6| 6| 6| 9| 5| 7| 4| 4| 5| 5| 5| 3| 5| 5| 6| 4| 6| 2| 5| 6| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Eosinophilic Focus | 2 3 3 3 X X |
Infiltration Cellular, Lymphocyte | 2 1 |
Inflammation, Chronic | 2 2 1 |
Karyomegaly | 2 3 |
Necrosis, Focal | 2 |
Necrosis | 2 |
Regeneration | |
Oval Cell, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + + + |
Angiectasis | |
Fat, Necrosis | 3 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Inflammation | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M M M M + M M M + + + + + + + + M M + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + I I + + + + + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 1| 3| 5| 3| 9| 3| 3| 7| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 9|
| 5| 9| 6| 6| 6| 6| 9| 5| 7| 4| 4| 5| 5| 5| 3| 5| 5| 6| 4| 6| 2| 5| 6| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 4 1 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 3 1 2 2 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + M + + + + + + M + + M M + M|
Cyst | 3 |
Inflammation | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + I + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 3 3 3 2 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Cystic | 2 3 2 1 3 2 2 2 2 1 3 3 3 2 2 1 3 2 2 1 3 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M + M M + + + M M + + M + + + + + M + + + M|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + M + + + + + + + M + + + M M M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + I + I + + + + + + + + + I + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + + M M + + + M + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M + + + + M + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + I + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + I|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 1| 3| 5| 3| 9| 3| 3| 7| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 9|
| 5| 9| 6| 6| 6| 6| 9| 5| 7| 4| 4| 5| 5| 5| 3| 5| 5| 6| 4| 6| 2| 5| 6| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Focal, | |
Histiocyte | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 2 2 1 2 1 2 1 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Nephropathy | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 9| |
| 5| 1| 3| 5| 6| 6| 6| 5| 6| 5| 5| 9| 6| 4| 6| 5| 6| 6| 5| 3| 0| 6| 9| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M + + + M + + + + + + + + + A + A + A| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X X | 2 |
Eosinophilic Focus | X X X | 9 2.8|
Infiltration Cellular, Lymphocyte | 2 | 3 1.7|
Inflammation, Chronic | 1 2 2 | 6 1.7|
Karyomegaly | 3 3 | 4 2.8|
Necrosis, Focal | 1 1 | 3 1.3|
Necrosis | | 1 2.0|
Regeneration | 2 | 1 2.0|
Oval Cell, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 10 |
Angiectasis | 3 | 1 3.0|
Fat, Necrosis | 4 2 | 7 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
Acinus, Atrophy | 4 | 1 4.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 2.0|
Artery, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Inflammation | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 9| |
| 5| 1| 3| 5| 6| 6| 6| 5| 6| 5| 5| 9| 6| 4| 6| 5| 6| 6| 5| 3| 0| 6| 9| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M + + + M + M + M M M + M M M + + M + M M M| 25 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 2 | 2 2.0|
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 1 1 2 1 1 2 3 | 12 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 1 2 1 1 1 1 1 1| 20 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + M + + + + + M + + + + + + + +| 41 |
Cyst | | 1 3.0|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + I + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 4 | 1 4.0|
Cyst | 2 2 2 | 9 2.4|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2| 1 2.0|
Hyperplasia, Cystic | 1 2 1 3 1 2 2 1 2 2 2 2 3 1 3 2| 37 2.0|
Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + + + + + + + M M M M M + + + M + + M M M +| 30 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + M + + M M M + + + + + + + + M M + + +| 37 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + I + + + + + + + + + +| 46 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Infiltration Cellular, Histiocyte | 4 | 1 4.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + M M M + + + + + + + + + M + + + + + + + +| 41 |
Hyperplasia, Lymphoid | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 9| |
| 5| 1| 3| 5| 6| 6| 6| 5| 6| 5| 5| 9| 6| 4| 6| 5| 6| 6| 5| 3| 0| 6| 9| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + M M + + + + + M + M + + M| 41 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
Hyperplasia | 3 | 3 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 4 1 | 2 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | +| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 | 2 2.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 3| 2 2.0|
Alveolar Epithelium, Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 | 3 1.7|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 1 1 1 1 1 2 | 20 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Degeneration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 9| |
| 5| 1| 3| 5| 6| 6| 6| 5| 6| 5| 5| 9| 6| 4| 6| 5| 6| 6| 5| 3| 0| 6| 9| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Infiltration Cellular, Mixed Cell | 2 2 | 3 2.0|
Nephropathy | 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 6| 6| 5| 6| 5| 6| 2| 9| 5| 6| 6| 5| 1| 6| 5| 5| 6| 6| 4| 4| 5| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 4 2 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic | 1|
Karyomegaly | 2|
Necrosis, Focal | 1|
Vacuolization Cytoplasmic | |
Oval Cell, Hyperplasia | 2|
__________________________________________________________________________|
Mesentery | + + + + + + |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | |
Fat, Necrosis | 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 4 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Squamous | 2 2 3 |
Inflammation | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 6| 6| 5| 6| 5| 6| 2| 9| 5| 6| 6| 5| 1| 6| 5| 5| 6| 6| 4| 4| 5| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | I M M + M + M + M M + M + + + + M + M M M M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + I + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + I + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 1 2 1 1 2 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + M + M + + + + + + + M M + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + I|
Angiectasis | 3 |
Cyst | 2 2 2 2 3 3 |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hydrometra | 3 3 |
Hyperplasia, Cystic | 2 2 1 3 2 2 2 2 2 3 2 2 2 1 3 2 2 2 2 1 2 |
Inflammation, Suppurative | |
Cervix, Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + + + M M M + + + + M M + + + M + M M + + +|
Hyperplasia, Lymphoid | 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + M + + + + M M + + + + + M + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + I + + + + + M + + + +|
Hyperplasia, Lymphoid | 2 3 4 3 |
Necrosis | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + M + M + + M + + + M M M + M + + M +|
Hyperplasia, Lymphoid | 2 3 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 3 3 3 2 |
Hyperplasia, Lymphoid | 2 3 4 3|
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + M + + + + + M M + + + M|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 6| 6| 5| 6| 5| 6| 2| 9| 5| 6| 6| 5| 1| 6| 5| 5| 6| 6| 4| 4| 5| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + I + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Focal, | |
Histiocyte | 2 2 1 3 |
Alveolar Epithelium, Hyperplasia | 2 |
Bronchus, Vacuolization Cytoplasmic | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 3 2 1 2 1 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 3 |
Inflammation, Chronic | |
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 6| 6| 5| 6| 5| 6| 2| 9| 5| 6| 6| 5| 1| 6| 5| 5| 6| 6| 4| 4| 5| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +|
Edema | 3 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 3| 3| 3| 2| 2| 6| 9| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 3| 3| 6| 3| 3| 3| |
| 4| 6| 5| 4| 5| 6| 0| 6| 3| 5| 6| 5| 4| 5| 4| 7| 5| 3| 4| 5| 6| 6| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + M + M + + + + + + + A + A + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + M + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X X X X | 7 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 2 3.0|
Infiltration Cellular, Mixed Cell | 3 | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Karyomegaly | 1 | 2 1.5|
Necrosis, Focal | | 1 1.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
Oval Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 12 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | 4 | 1 4.0|
Fat, Necrosis | 3 3 3 3 4 | 8 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
Acinus, Atrophy | 4 | 2 4.0|
Duct, Cyst | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Hyperplasia, Squamous | | 3 2.3|
Inflammation | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 3| 3| 3| 2| 2| 6| 9| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 3| 3| 6| 3| 3| 3| |
| 4| 6| 5| 4| 5| 6| 0| 6| 3| 5| 6| 5| 4| 5| 4| 7| 5| 3| 4| 5| 6| 6| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M M + + M M M + + + + M + M M M + + M M M +| 23 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + + + + I + + + + + + +| 47 |
Angiectasis | 3 | 5 2.2|
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 2 4 1 2 3 1 2 | 17 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + + + M + M + + + + M + + + + M| 40 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Cyst | 2 2 2 3 3 2 | 12 2.3|
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Hydrometra | 4 | 3 3.3|
Hyperplasia, Cystic | 2 2 2 2 3 3 2 2 2 3 2 2 2 3 2 2 2 2 2 4| 41 2.1|
Inflammation, Suppurative | 3 | 1 3.0|
Cervix, Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 6 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Renal, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M + + + + + + + + + + + + + + M M + + M + + +| 34 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M + + M + + + + M + M + M + + + + + + M + M| 37 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + M + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 3| 3| 3| 2| 2| 6| 9| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 3| 3| 6| 3| 3| 3| |
| 4| 6| 5| 4| 5| 6| 0| 6| 3| 5| 6| 5| 4| 5| 4| 7| 5| 3| 4| 5| 6| 6| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 3 | 5 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + M + M + + + M + M + + + + + + + + + +| 36 |
Hyperplasia, Lymphoid | 3 4 | 5 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 2 3 | 11 2.7|
Hyperplasia, Lymphoid | 4 | 5 3.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +| 44 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 1 | 4 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
Ulcer | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 1 | 5 1.8|
Alveolar Epithelium, Hyperplasia | 1 1 | 3 1.3|
Bronchus, Vacuolization Cytoplasmic | 1 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
Olfactory Epithelium, Atrophy | 2 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 3| 3| 3| 2| 2| 6| 9| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 3| 3| 6| 3| 3| 3| |
| 4| 6| 5| 4| 5| 6| 0| 6| 3| 5| 6| 5| 4| 5| 4| 7| 5| 3| 4| 5| 6| 6| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 1 1.0|
Olfactory Epithelium, Metaplasia | | 1 2.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 2 1 1| 16 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | | 1 3.0|
Inflammation, Chronic | 1 | 1 1.0|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + + + + A + + + + + + +| 47 |
Edema | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 0| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 7| 3| 9| 3| 3| 5| 3| 3| 6| 2| 3| 3| 3| 3| 0| 0| 3| 2| 0| 3| 3|
| 5| 5| 4| 5| 4| 5| 5| 5| 3| 9| 4| 6| 6| 0| 5| 5| 6| 4| 5| 9| 5| 4| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Gallbladder | + + + + M + A M A + M + + M + + + + + + M + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + A + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + A + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + A + + + + + + + + + + + + + A + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Cyst | 2 |
Eosinophilic Focus | X X 3 X|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | |
Mineralization | |
Necrosis, Focal | 2 |
Vacuolization Cytoplasmic, Diffuse | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + M + +|
Infiltration Cellular, Lymphocyte | 2 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Squamous | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + A + +|
Cyst, Focal | |
Vacuolization Cytoplasmic | 4 |
Capsule, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Parathyroid Gland | M I + + M + M + + M + M M M + + + + M + + M A + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + I + + + + + + + + + + + + + + A + +|
Angiectasis | |
Pars Distalis, Hyperplasia | 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 0| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 7| 3| 9| 3| 3| 5| 3| 3| 6| 2| 3| 3| 3| 3| 0| 0| 3| 2| 0| 3| 3|
| 5| 5| 4| 5| 4| 5| 5| 5| 3| 9| 4| 6| 6| 0| 5| 5| 6| 4| 5| 9| 5| 4| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A + +|
Cyst | |
Infiltration Cellular, Lymphocyte | |
Follicular Cell, Hyperplasia | 3 3 1 2 1 1 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + A + +|
Angiectasis | 2 |
Atrophy | 2 2 |
Cyst | 2 2 3 2 3 2 |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + A + +|
Angiectasis | |
Hydrometra | 2 |
Hyperplasia, Cystic | 2 2 1 1 2 2 2 2 2 3 3 1 2 1 2 2 3 3 2|
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Lymph Node | + |
Iliac, Ectasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M M + M + M M + + M + + + + M M + M + M M M|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + M + M + M + + + + + I + M M + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + M + M + + M M + + + M + + M M + A + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hematopoietic Cell Proliferation | 2 3 3 4 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + M + + M + + + M + + + + A + +|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 0| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 7| 3| 9| 3| 3| 5| 3| 3| 6| 2| 3| 3| 3| 3| 0| 0| 3| 2| 0| 3| 3|
| 5| 5| 4| 5| 4| 5| 5| 5| 3| 9| 4| 6| 6| 0| 5| 5| 6| 4| 5| 9| 5| 4| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Ulcer | 3 |
Subcutaneous Tissue, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
Fracture | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + I + + + + A + +|
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Histiocyte | 4 2 2 |
Inflammation, Chronic | 2 |
Bronchus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hemorrhage | 3 |
Inflammation, Suppurative | 2 2 |
Olfactory Epithelium, Atrophy | 1 1 1 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 2 2 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic | 1 |
Metaplasia, Osseous | |
Nephropathy | 1 2 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + A + I|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 6| 3| 4| 2| 3| 3| 3| 3| 4| 6| 3| 3| 3| 4| 3| 3| |
| 6| 6| 6| 9| 7| 5| 6| 6| 6| 6| 5| 8| 2| 4| 6| 5| 5| 9| 9| 6| 6| 6| 0| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + M + + M + + + + + + + M + + + + + + + + + A + +| 38 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Peyer's Patch, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X | 1 |
Cyst | | 1 2.0|
Eosinophilic Focus | X X X X | 8 3.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Mineralization | 3 | 1 3.0|
Necrosis, Focal | 4 | 2 3.0|
Vacuolization Cytoplasmic, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Fat, Necrosis | 3 3 2 3 | 7 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Duct, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst, Focal | 4 | 1 4.0|
Vacuolization Cytoplasmic | | 1 4.0|
Capsule, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 6| 3| 4| 2| 3| 3| 3| 3| 4| 6| 3| 3| 3| 4| 3| 3| |
| 6| 6| 6| 9| 7| 5| 6| 6| 6| 6| 5| 8| 2| 4| 6| 5| 5| 9| 9| 6| 6| 6| 0| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M M + + + M M M M + M M + M M + + M| 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 3 1 | 7 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 2 2 3 2 2 2 2 | 14 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M M M + + M + M + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Atrophy | | 2 2.0|
Cyst | 3 3 2 2 3 3 3 2 2 3| 16 2.5|
Bilateral, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 4 | 1 4.0|
Hydrometra | 3 3 | 3 2.7|
Hyperplasia, Cystic | 1 3 1 2 2 1 2 2 1 2 1 3 2 3 3 2 2 2 1| 38 1.9|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 3 |
Iliac, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M + M + + + + + M M + + + + M M + + + M M +| 27 |
Hyperplasia, Lymphoid | 2| 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M + + + + + + + M M + + + + M + + M + + + M| 36 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + M + + + + M +| 46 |
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M M + + M M M M + M M + + M + + + M M M + + +| 28 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 6| 3| 4| 2| 3| 3| 3| 3| 4| 6| 3| 3| 3| 4| 3| 3| |
| 6| 6| 6| 9| 7| 5| 6| 6| 6| 6| 5| 8| 2| 4| 6| 5| 5| 9| 9| 6| 6| 6| 0| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 3 3 3 2 | 9 2.8|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M M + + + + + + + M + + + + + + + + + + M +| 41 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
Ulcer | | 1 3.0|
Subcutaneous Tissue, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 2.0|
Fracture | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + I + +| 47 |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Histiocyte | 3 2 4 3| 7 2.9|
Inflammation, Chronic | | 1 2.0|
Bronchus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 31 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | 1 1 2 | 5 1.6|
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 1| 12 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2| 2 1.5|
Olfactory Epithelium, Metaplasia | | 1 2.0|
Respiratory Epithelium, Degeneration,| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 6| 3| 4| 2| 3| 3| 3| 3| 4| 6| 3| 3| 3| 4| 3| 3| |
| 6| 6| 6| 9| 7| 5| 6| 6| 6| 6| 5| 8| 2| 4| 6| 5| 5| 9| 9| 6| 6| 6| 0| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hyaline | 1 1 1 1 1 2 2| 14 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Metaplasia, Osseous | 2 | 1 2.0|
Nephropathy | 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + I + + + + + + + + + + + + A + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 0| 3| 3| 5| 0| 3| 3| 9| 3| 4| 3| 3| 3| 1| 8| 3| 6| 3| 8| 1| 3| 3|
| 6| 0| 9| 6| 6| 5| 6| 6| 5| 2| 2| 6| 3| 4| 5| 6| 2| 6| 5| 2| 5| 4| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + A + + + A M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A A + A + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A A + A + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Clear Cell Focus, Multiple | X |
Cyst | 4 |
Eosinophilic Focus | X X X X |
Eosinophilic Focus, Multiple | |
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic | 2 |
Karyomegaly | 2 |
Necrosis, Focal | |
Thrombosis | |
Vacuolization Cytoplasmic, Diffuse | 2 |
Serosa, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | |
Fat, Necrosis | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epicardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Inflammation | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + M M + + I + + M M M I M M + + + M M|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 0| 3| 3| 5| 0| 3| 3| 9| 3| 4| 3| 3| 3| 1| 8| 3| 6| 3| 8| 1| 3| 3|
| 6| 0| 9| 6| 6| 5| 6| 6| 5| 2| 2| 6| 3| 4| 5| 6| 2| 6| 5| 2| 5| 4| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + I + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + I + + + + + + + + + + + + + + + + +|
Inflammation | |
Follicular Cell, Hyperplasia | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + M + + + + + + + + + + + + M M + M + + M +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + I + + + + + + + +|
Cyst | 2 2 3 2 3 3 2 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3|
Hyperplasia, Cystic | 2 2 3 1 2 1 1 2 3 2 1 2 2 2 2 2 2 2 2 |
Inflammation | 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M M + + + M + M M + + + + + + M + M + + M + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + I + M M M + + + + M M M + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + I + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + M + + + M M + + + + M M + + M + M + + + M|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + M + M + + M + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 1 2 4|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 0| 3| 3| 5| 0| 3| 3| 9| 3| 4| 3| 3| 3| 1| 8| 3| 6| 3| 8| 1| 3| 3|
| 6| 0| 9| 6| 6| 5| 6| 6| 5| 2| 2| 6| 3| 4| 5| 6| 2| 6| 5| 2| 5| 4| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Fracture | X |
Maxilla, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | + |
Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 2 |
Infiltration Cellular, Diffuse, | |
Histiocyte | 4 |
Infiltration Cellular, Focal, | |
Histiocyte | 3 2 2 3 2 3 2 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
Bronchus, Vacuolization Cytoplasmic | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Capillary, Thrombosis, Diffuse | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 2 1 2 1 |
Olfactory Epithelium, Atrophy | 1 1 1 2 1 2 2 1 1 2 1 2 2 1 1 1 1 1 1 2 1 1|
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 |
Olfactory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 3 2 1 1 2 1 1 1|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 4 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2|
Infarct | 3 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 8| 3| 0| 3| 3| 5| 0| 3| 3| 9| 3| 4| 3| 3| 3| 1| 8| 3| 6| 3| 8| 1| 3| 3|
| 6| 0| 9| 6| 6| 5| 6| 6| 5| 2| 2| 6| 3| 4| 5| 6| 2| 6| 5| 2| 5| 4| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Mixed Cell | |
Mineralization | 2 |
Nephropathy | 1 1 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 0| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 1| 3| 3| 3| 3| 3| 6| 3| |
| 6| 9| 6| 6| 4| 9| 5| 5| 6| 5| 5| 5| 4| 6| 1| 6| 6| 7| 6| 6| 9| 6| 6| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + A + + + + + + + + + A + + + + + M +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + A + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + A + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Clear Cell Focus | | 1 |
Clear Cell Focus, Multiple | | 1 |
Cyst | | 1 4.0|
Eosinophilic Focus | X X X X X | 9 |
Eosinophilic Focus, Multiple | X | 1 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Chronic | 2 | 2 2.0|
Karyomegaly | | 1 2.0|
Necrosis, Focal | 2 3 | 2 2.5|
Thrombosis | 4 | 1 4.0|
Vacuolization Cytoplasmic, Diffuse | | 1 2.0|
Serosa, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + +| 7 |
Hemorrhage | 3 | 1 3.0|
Fat, Necrosis | 4 3 4| 5 3.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Acinus, Atrophy | 1 | 3 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 1 | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epicardium, Fibrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 0| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 1| 3| 3| 3| 3| 3| 6| 3| |
| 6| 9| 6| 6| 4| 9| 5| 5| 6| 5| 5| 5| 4| 6| 1| 6| 6| 7| 6| 6| 9| 6| 6| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Inflammation | 2 | 1 2.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + I + M M + M + + M + + + + + M + I + M M M| 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Angiectasis | 1 2 | 2 1.5|
Pars Distalis, Hyperplasia | 2 2 1 | 6 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 2 1 1 3 1 2 2 4 2 1 1 1 1 4 | 19 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + M + + + M + + + + + + M + M| 40 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Cyst | 2 3 2 2 1 1 | 15 2.1|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Hydrometra | 4 | 2 3.5|
Hyperplasia, Cystic | 3 2 2 3 4 3 3 3 2 1 2 1 2 2 2 1 3 1| 37 2.1|
Inflammation | 3 | 2 2.0|
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + M + + + + + + M + + M + M M + + M +| 35 |
Hyperplasia, Lymphoid | 3 2 2 | 3 2.3|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + M M + + + M + + + M| 36 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + A + + M + + + +| 44 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + + + + + + M M M M M + + + + M + + + +| 34 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 3 | 3 3.0|
Hyperplasia, Lymphoid | 2 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 0| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 1| 3| 3| 3| 3| 3| 6| 3| |
| 6| 9| 6| 6| 4| 9| 5| 5| 6| 5| 5| 5| 4| 6| 1| 6| 6| 7| 6| 6| 9| 6| 6| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + M + + + M + M + + + + + + + + + + + + + + M M +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 5 2.0|
Fracture | | 1 |
Maxilla, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Metaplasia, Squamous | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1| 50 1.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 2 | 4 2.8|
Infiltration Cellular, Diffuse, | | |
Histiocyte | 3 4 2 | 4 3.3|
Infiltration Cellular, Focal, | | |
Histiocyte | 3 2 2| 10 2.4|
Inflammation, Chronic | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 2| 5 2.0|
Bronchus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0|
Capillary, Thrombosis, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Suppurative | | 4 1.5|
Olfactory Epithelium, Atrophy | 2 1 1 1 1 1 1 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 1 2| 46 1.5|
Olfactory Epithelium, Degeneration, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 0| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 3| 3| 1| 3| 2| 1| 3| 3| 3| 3| 3| 6| 3| |
| 6| 9| 6| 6| 4| 9| 5| 5| 6| 5| 5| 5| 4| 6| 1| 6| 6| 7| 6| 6| 9| 6| 6| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hyaline | 1 | 2 1.0|
Olfactory Epithelium, Hyperplasia | 1 1 2 1 1 1 1 2 2 1 2 1 1 1| 30 1.3|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 2 1 2 | 11 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 2.5|
Infarct | | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 1 2 | 3 1.7|
Mineralization | | 1 2.0|
Nephropathy | 1 | 3 1.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | I + + + + + + + + + + + + + + + + A + + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 4| 7| 5| 6| 7| 6| 6| 7| 4| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 3| 3| 0| 8| 3| 7| 3| 7| 0| 3| 8| 5| 3| 4| 4| 3| 3| 4| 3| 3| 0| 3| 3| 8|
| 2| 4| 4| 0| 0| 4| 0| 3| 5| 0| 3| 6| 1| 3| 9| 1| 4| 3| 1| 3| 3| 8| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + M + + M + + + A + + A + + + + + + + + M|
Degeneration, Hyaline | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | X 2 2 X |
Eosinophilic Focus, Multiple | 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 1 1 1 1 1 1 2 1 1 1 2 1 1 2 2 3 2 2 1|
Karyomegaly | 3 3 3 3 3 2 2 2 3 2 2 2 3 2 3 2 1 3 3 2 2|
Mineralization | 3 |
Necrosis, Focal | 2 |
Regeneration | 3 3 3 3 2 1 1 3 2 3 2 3 2 3 3 3 3 1|
Oval Cell, Hyperplasia | 3 3 2 3 3 2 3 3 3 2 3 2 2 2 3 2 3 3 3 2 3|
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | 3 |
Artery, Fibrosis | 3 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + M + I M M M M M + + M M + M M M M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 4| 7| 5| 6| 7| 6| 6| 7| 4| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 3| 3| 0| 8| 3| 7| 3| 7| 0| 3| 8| 5| 3| 4| 4| 3| 3| 4| 3| 3| 0| 3| 3| 8|
| 2| 4| 4| 0| 0| 4| 0| 3| 5| 0| 3| 6| 1| 3| 9| 1| 4| 3| 1| 3| 3| 8| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Chronic | 1 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + M M + I M M M M + M + M M M M + + + + M M|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + + + M + M + + + M + + M M + + + + M M + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + M + + M + + + + + + + + + + + + + + + M + +|
Infiltration Cellular, Plasma Cell | 3 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Thymus | + M + + I I + + M + M M + + M + M M M + + + + M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Ulcer | 4 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 4| 7| 5| 6| 7| 6| 6| 7| 4| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 3| 3| 0| 8| 3| 7| 3| 7| 0| 3| 8| 5| 3| 4| 4| 3| 3| 4| 3| 3| 0| 3| 3| 8|
| 2| 4| 4| 0| 0| 4| 0| 3| 5| 0| 3| 6| 1| 3| 9| 1| 4| 3| 1| 3| 3| 8| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Diffuse, | |
Histiocyte | 3 |
Infiltration Cellular, Focal, | |
Histiocyte | 3 3 3 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 2 1 2|
Inflammation, Chronic | |
Nephropathy | 1 2 1 4 1 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation | 3 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 5| 6| 7| 6| |
DAY ON TEST | 7| 4| 4| 5| 3| 3| 5| 8| 3| 3| 1| 3| 8| 3| 2| 3| 1| 3| 8| 3| 3| 7| 4| 3| 1| |
| 6| 0| 9| 5| 3| 4| 2| 2| 4| 3| 1| 4| 6| 4| 5| 3| 6| 3| 6| 3| 4| 9| 3| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M A + + + + + + M + + A A + + M A + +| 37 |
Degeneration, Hyaline | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + A + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + A A + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + A A + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + A A + + + A + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 | 1 1.0|
Eosinophilic Focus | X X X X | 8 2.0|
Eosinophilic Focus, Multiple | | 1 2.0|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Inflammation, Chronic | 1 1 1 1 1 1 2 2 1 1 1 2 1 1 | 33 1.3|
Karyomegaly | 3 1 2 3 1 1 2 3 3 3 2 3 3 1 2 3 3 1| 39 2.3|
Mineralization | | 1 3.0|
Necrosis, Focal | 2 4 | 3 2.7|
Regeneration | 3 1 1 3 2 1 3 3 1 2 2 3 3 3 | 32 2.3|
Oval Cell, Hyperplasia | 3 2 3 3 1 2 3 3 3 3 3 3 1 2 3 3 1| 38 2.6|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Inflammation, Chronic | | 1 3.0|
Artery, Fibrosis | | 1 3.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + A + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Squamous | 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + A + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1| 1 1.0|
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 5| 6| 7| 6| |
DAY ON TEST | 7| 4| 4| 5| 3| 3| 5| 8| 3| 3| 1| 3| 8| 3| 2| 3| 1| 3| 8| 3| 3| 7| 4| 3| 1| |
| 6| 0| 9| 5| 3| 4| 2| 2| 4| 3| 1| 4| 6| 4| 5| 3| 6| 3| 6| 3| 4| 9| 3| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M M + M A M M M + + + M + M I M + M M + + +| 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 2| 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Granuloma Sperm | | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 3.0|
Inflammation, Chronic | 1 2 2 3 3 1 2 3 3| 13 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + A + + + + + + + + + + + I + + A + +| 46 |
Inflammation | 3| 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M M M + M M M + + + M + M I M + + + + + M M I| 21 |
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M A M + M + + + + M M M M M M M + + M| 22 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 2 2.5|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + A + + + + + + M + + + M + + + + + +| 43 |
Infiltration Cellular, Plasma Cell | | 1 3.0|
Infiltration Cellular, Histiocyte | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + + + + + M + + + A + + + + + +| 47 |
Angiectasis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 3 3| 10 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 5| 6| 7| 6| |
DAY ON TEST | 7| 4| 4| 5| 3| 3| 5| 8| 3| 3| 1| 3| 8| 3| 2| 3| 1| 3| 8| 3| 3| 7| 4| 3| 1| |
| 6| 0| 9| 5| 3| 4| 2| 2| 4| 3| 1| 4| 6| 4| 5| 3| 6| 3| 6| 3| 4| 9| 3| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | M + M + M + + A + + M + M M + I M + + + + + M + +| 28 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Prepuce, Ulcer | 3 4| 4 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + M + A + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | X | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Infiltration Cellular, Diffuse, | | |
Histiocyte | | 1 3.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 3 2 3 3 3 | 10 2.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Mixed Cell | 1 1 | 5 1.4|
Inflammation, Chronic | 4| 1 4.0|
Nephropathy | 2 1 1 3 | 11 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + A + + + A + +| 46 |
Inflammation | 4 4| 3 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 4| 3| 3| 3| 1| 3| 2| 3| 6| 1| 3| 3| 6| 3| 3| 8| 3| 3| 9| 3| 2| 3| 3| 8| 0|
| 1| 3| 3| 3| 1| 3| 0| 4| 6| 7| 3| 4| 0| 4| 3| 3| 4| 4| 0| 4| 6| 4| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + M + M M + + + + + M + + + + + M + + +|
Degeneration, Hyaline | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X |
Eosinophilic Focus, Multiple | |
Inflammation, Chronic | 1 1 1 1 2 2 1 1 2 1 1 2 3 2 2 1 2 1|
Karyomegaly | 3 2 2 3 3 3 3 3 3 3 2 3 2 3 4 3 3 3|
Necrosis, Focal | 2 2 3 |
Regeneration | 2 2 2 3 2 3 3 2 2 2 3 3 3 |
Vacuolization Cytoplasmic, Diffuse | 3 2 2 |
Bile Duct, Hyperplasia | 1 1 |
Oval Cell, Hyperplasia | 3 2 2 3 3 3 3 3 3 3 2 3 2 3 3 3 3 3|
__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic | 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Atrium, Thrombosis | 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
Inflammation | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + + M + + + + + + M M + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 4| 3| 3| 3| 1| 3| 2| 3| 6| 1| 3| 3| 6| 3| 3| 8| 3| 3| 9| 3| 2| 3| 3| 8| 0|
| 1| 3| 3| 3| 1| 3| 0| 4| 6| 7| 3| 4| 0| 4| 3| 3| 4| 4| 0| 4| 6| 4| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 3 1 1 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Chronic | 1 2 2 1 1 1|
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Iliac, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M M + M + M + + M + M M + + M M M + + M + + M|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + M + M + M + M M M M M M + M + M M M M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M M + M + + + + + M + + + M M + M M + M M +|
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Thymus | I + + + M + + M + + + + M M + + + + M + M M M M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
Ulcer | |
Prepuce, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 4| 3| 3| 3| 1| 3| 2| 3| 6| 1| 3| 3| 6| 3| 3| 8| 3| 3| 9| 3| 2| 3| 3| 8| 0|
| 1| 3| 3| 3| 1| 3| 0| 4| 6| 7| 3| 4| 0| 4| 3| 3| 4| 4| 0| 4| 6| 4| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Prepuce, Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Diffuse, | |
Histiocyte | 3|
Infiltration Cellular, Focal, | |
Histiocyte | 3 2 3 2 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
Alveolar Epithelium, Goblet Cell, | |
Metaplasia, Focal | |
Bronchus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + +|
Inflammation, Acute | 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, Mixed Cell | |
Nephropathy | 3 3 2 1 2 4|
Glomerulus, Amyloid Deposition | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 4| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 1| 9| 3| 3| 3| 3| 5| 5| 3| 3| |
| 9| 4| 3| 3| 9| 3| 5| 3| 3| 3| 4| 6| 3| 4| 3| 4| 9| 4| 4| 3| 4| 3| 2| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + M + + + + + + + + A + M + + + + + +| 41 |
Degeneration, Hyaline | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | | 3 |
Eosinophilic Focus | X X X X| 7 |
Eosinophilic Focus, Multiple | X | 1 |
Inflammation, Chronic | 2 2 2 1 1 1 1 2 2 2 1 1 1 2 2 2 2 2| 36 1.6|
Karyomegaly | 3 3 3 3 2 2 3 3 3 2 3 3 3 3 3 3 3| 35 2.8|
Necrosis, Focal | | 3 2.3|
Regeneration | 3 3 3 2 3 3 2 3 3 3 2 3 3 3 2 4 3| 30 2.7|
Vacuolization Cytoplasmic, Diffuse | | 3 2.3|
Bile Duct, Hyperplasia | 2 | 3 1.3|
Oval Cell, Hyperplasia | 3 3 3 3 2 1 2 3 3 3 3 3 3 3 3 3 3 3| 36 2.8|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Artery, Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 4 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 | 4 1.0|
Atrium, Thrombosis | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1| 4 1.0|
Inflammation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 4| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 1| 9| 3| 3| 3| 3| 5| 5| 3| 3| |
| 9| 4| 3| 3| 9| 3| 5| 3| 3| 3| 4| 6| 3| 4| 3| 4| 9| 4| 4| 3| 4| 3| 2| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + M + + + + M M + M + + + + + M I + +| 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 3 2 1 4| 17 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1| 2 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 2 3.0|
Inflammation, Chronic | 2 1 2 1 1 2 | 12 1.4|
Inflammation, Suppurative | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M + + M M M M + + + + M M + + + I + M + M M +| 24 |
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + M + M + + + + M + + + M M + M M M M + M +| 21 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Hemorrhage | 2 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + M M M M + M + + M + + + + + + M + M + M M| 28 |
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 3 3 | 6 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 4| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 1| 9| 3| 3| 3| 3| 5| 5| 3| 3| |
| 9| 4| 3| 3| 9| 3| 5| 3| 3| 3| 4| 6| 3| 4| 3| 4| 9| 4| 4| 3| 4| 3| 2| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Thymus | M + + + M + M + M M + + + I + + + + M + + + + + M| 31 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
Ulcer | 2 | 1 2.0|
Prepuce, Inflammation, Chronic | | 1 3.0|
Prepuce, Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + I + + + + + + + + + + + + + + + + +| 49 |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 37 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Diffuse, | | |
Histiocyte | 3 | 2 3.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 3 | 5 2.6|
Inflammation, Chronic | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 | 4 2.3|
Alveolar Epithelium, Goblet Cell, | | |
Metaplasia, Focal | 3 | 1 3.0|
Bronchus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 | 18 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 4| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 1| 9| 3| 3| 3| 3| 5| 5| 3| 3| |
| 9| 4| 3| 3| 9| 3| 5| 3| 3| 3| 4| 6| 3| 4| 3| 4| 9| 4| 4| 3| 4| 3| 2| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
Nephropathy | 1 2 1 2 2 3 1 | 13 2.1|
Glomerulus, Amyloid Deposition | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 5| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 7| 3| 0| 3| 3| 0| 3| 8| 3| 3| 4| 3| 3| 0| 3| 3| 3| 0| 5| 3|
| 3| 3| 4| 0| 3| 0| 4| 5| 4| 3| 9| 3| 1| 3| 4| 8| 3| 4| 8| 3| 3| 3| 5| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + M A + + M + + + A + + A + + + + + + M + +|
Degeneration, Hyaline | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + A + + A + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | 2 |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Clear Cell Focus, Multiple | |
Eosinophilic Focus | X X X X X X |
Eosinophilic Focus, Multiple | X |
Inflammation, Chronic | 1 1 2 2 1 2 1 2 2 2 2 2 2 2 2 1 2 1 2 1|
Karyomegaly | 1 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 2|
Necrosis, Focal | 3 2 3 |
Regeneration | 2 2 3 2 3 3 2 2 2 3 3 3 3 2 1 2 3 |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | 1 |
Bile Duct, Hyperplasia | 2 |
Oval Cell, Hyperplasia | 1 3 3 3 3 3 3 3 1 3 2 3 3 3 3 3 3 3 1|
__________________________________________________________________________|
Mesentery | + + |
Mineralization | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Inflammation, Chronic | 2 |
Artery, Inflammation, Chronic | |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 5| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 7| 3| 0| 3| 3| 0| 3| 8| 3| 3| 4| 3| 3| 0| 3| 3| 3| 0| 5| 3|
| 3| 3| 4| 0| 3| 0| 4| 5| 4| 3| 9| 3| 1| 3| 4| 8| 3| 4| 8| 3| 3| 3| 5| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + M + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Hyperplasia | 2 1 1 |
Necrosis, Diffuse | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +|
Necrosis, Diffuse | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + + M M M M + + + + + M + + M + M M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 4 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Mineralization | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
Inflammation, Chronic | 2 1 1 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Prostate | + + + + M + + + + + + + A + + + M + + + + + + M +|
Inflammation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
Iliac, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M M + A + M + M M M + + + M + + M + + + + M M|
__________________________________________________________________________|
Lymph Node, Mandibular | M M M M + + M M M + + + M + + M + M + + + + M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + M + A + + M + + + A + + A + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 3 |
Inflammation, Chronic | 2 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + I + + + M + + + + M + + + + + + M M + M M M M|
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 5| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 7| 3| 0| 3| 3| 0| 3| 8| 3| 3| 4| 3| 3| 0| 3| 3| 3| 0| 5| 3|
| 3| 3| 4| 0| 3| 0| 4| 5| 4| 3| 9| 3| 1| 3| 4| 8| 3| 4| 8| 3| 3| 3| 5| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 |
__________________________________________________________________________|
Thymus | M + + M + + + M M + + + M + + M M M M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Epidermis, Hyperplasia | |
Prepuce, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + A + + + + + I + + + + + + + + + + + + +|
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Diffuse, | |
Histiocyte | 1 2 3 |
Infiltration Cellular, Focal, | |
Histiocyte | 3 3 4 4 2 |
Inflammation, Chronic | 3 |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Thrombosis | |
Bronchus, Hyperplasia | 3 |
Bronchus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + A + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | 1 2 1 1 1 2 1 2 2 2 1 1 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation | 3 |
__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 5| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 7| 3| 0| 3| 3| 0| 3| 8| 3| 3| 4| 3| 3| 0| 3| 3| 3| 0| 5| 3|
| 3| 3| 4| 0| 3| 0| 4| 5| 4| 3| 9| 3| 1| 3| 4| 8| 3| 4| 8| 3| 3| 3| 5| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 2 2 3 |
Inflammation, Chronic | 1 |
Metaplasia, Osseous | |
Nephropathy | 1 1 4 1 3 |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + A + + A + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 6| 4| 6| 7| 6| 5| 4| 7| 7| 5| 5| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 1| 3| 8| 0| 4| 3| 4| 5| 8| 4| 3| 3| 5| 6| 8| 3| 3| 2| 6| 9| 9| 3| 3| |
| 3| 3| 0| 4| 1| 6| 5| 3| 5| 2| 7| 0| 9| 4| 3| 0| 3| 3| 4| 3| 1| 7| 9| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + A + + A + A + + A + + + M +| 38 |
Degeneration, Hyaline | 3 2 | 2 2.5|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + I + + + + + M + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + A + + A + A + + M + + + + +| 42 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + A + + A + A + + A + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + A + A + + A + + + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X X | 2 |
Clear Cell Focus, Multiple | X | 1 |
Eosinophilic Focus | X X X | 9 |
Eosinophilic Focus, Multiple | X X| 3 |
Inflammation, Chronic | 1 2 2 2 2 2 2 2 1 2 2 2 1 2 1 1 2 2 2 3| 40 1.7|
Karyomegaly | 3 3 3 3 3 3 3 2 3 2 3 3 2 2 3 2 2 3 3 3 3| 39 2.7|
Necrosis, Focal | 2 2 2 | 6 2.3|
Regeneration | 2 3 3 3 2 2 3 2 2 3 2 1 4 2 2 3 2 3| 35 2.4|
Vacuolization Cytoplasmic, Diffuse | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 1 1.0|
Bile Duct, Hyperplasia | 2 2 1 2 1| 6 1.7|
Oval Cell, Hyperplasia | 3 3 3 3 3 3 3 2 3 3 3 3 3 2 3 2 2 3 3 3 3| 40 2.7|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Mineralization | 4 | 1 4.0|
Fat, Necrosis | 4 3 | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 3 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 6| 4| 6| 7| 6| 5| 4| 7| 7| 5| 5| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 1| 3| 8| 0| 4| 3| 4| 5| 8| 4| 3| 3| 5| 6| 8| 3| 3| 2| 6| 9| 9| 3| 3| |
| 3| 3| 0| 4| 1| 6| 5| 3| 5| 2| 7| 0| 9| 4| 3| 0| 3| 3| 4| 3| 1| 7| 9| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 2.0|
Artery, Inflammation, Chronic | 2 | 1 2.0|
Atrium, Thrombosis | 2 4 | 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Hyperplasia | 1 1 | 5 1.2|
Necrosis, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M M M M + M + M M + M + M M + + M M + + M| 24 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 3 3 1 1 1 | 11 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 3 3.0|
Inflammation, Chronic | 1 1 2 1 1 3 | 9 1.4|
Inflammation, Suppurative | 3 | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + I + + + M + + + + + + + + + + + + + + + + + +| 44 |
Inflammation | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 6| 4| 6| 7| 6| 5| 4| 7| 7| 5| 5| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 1| 3| 8| 0| 4| 3| 4| 5| 8| 4| 3| 3| 5| 6| 8| 3| 3| 2| 6| 9| 9| 3| 3| |
| 3| 3| 0| 4| 1| 6| 5| 3| 5| 2| 7| 0| 9| 4| 3| 0| 3| 3| 4| 3| 1| 7| 9| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Infiltration Cellular, | | |
Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + + + M + + + M M M M M + + M M M| 28 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M + + + M + + M M + M + + + M + + M + + M + +| 29 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 43 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hemorrhage | 3 3 | 4 2.8|
Inflammation, Chronic | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M M M + M M + + + + + + M + + + M M + + + M| 31 |
Hyperplasia, Lymphoid | 3 3 2 | 4 2.8|
Infiltration Cellular, Histiocyte | | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + M + + + + + M + + M M M + + + M + I + +| 33 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + I + + + + + + + + + + + + + + +| 49 |
Ulcer | 2 3 | 2 2.5|
Epidermis, Hyperplasia | 2 | 1 2.0|
Prepuce, Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Diffuse, | | |
Histiocyte | 3 | 4 2.3|
Infiltration Cellular, Focal, | | |
Histiocyte | 3 3 2| 8 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 6| 4| 6| 7| 6| 5| 4| 7| 7| 5| 5| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 1| 3| 8| 0| 4| 3| 4| 5| 8| 4| 3| 3| 5| 6| 8| 3| 3| 2| 6| 9| 9| 3| 3| |
| 3| 3| 0| 4| 1| 6| 5| 3| 5| 2| 7| 0| 9| 4| 3| 0| 3| 3| 4| 3| 1| 7| 9| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 1 4 1 | 4 1.8|
Artery, Thrombosis | 2 | 1 2.0|
Bronchus, Hyperplasia | | 1 3.0|
Bronchus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1| 29 1.2|
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | 2 2 | 5 2.2|
Inflammation, Chronic | | 1 1.0|
Metaplasia, Osseous | 2 | 1 2.0|
Nephropathy | 2 1 | 7 1.9|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + I + + + + + + + + + + + A + + + + + + + + + +| 45 |
Inflammation | 3 3 3 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 4| 7| 7| 7| 7| 7| 5| 5| 5| 7| 5| 7| 5| 7| 7| 5| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 1| 1| 1| 3| 3| 3| 3| 3| 4| 6| 2| 3| 2| 3| 5| 3| 3| 5| 3| 1| 5| 3|
| 3| 3| 3| 1| 3| 4| 3| 4| 3| 3| 4| 1| 0| 7| 4| 4| 4| 5| 4| 3| 2| 6| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + A + + M + + + + + A + + M + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Eosinophilic Focus | |
Inflammation, Chronic | 1 2 1 1 3 2 2 1 2 3 2 1 1 1 1 1 1 1 1 |
Karyomegaly | 3 2 3 3 3 1 1 3 2 3 3 3 2 3 3 2 3 3 3 3 3 2 3 |
Mitotic Alteration | 3 |
Necrosis, Focal | |
Regeneration | 2 3 3 2 3 3 3 2 3 3 3 1 3 2 3 3 3 3 2 3 |
Bile Duct, Hyperplasia | 1 3 |
Oval Cell, Hyperplasia | 3 2 3 3 3 1 3 3 3 3 3 2 3 3 2 3 3 2 3 3 3 3 1|
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic | 2 |
Artery, Fibrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 4 |
Inflammation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Tooth | + |
Inflammation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Atrium, Thrombosis | 4 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + + + + + + + + M + + + + + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 4| 7| 7| 7| 7| 7| 5| 5| 5| 7| 5| 7| 5| 7| 7| 5| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 1| 1| 1| 3| 3| 3| 3| 3| 4| 6| 2| 3| 2| 3| 5| 3| 3| 5| 3| 1| 5| 3|
| 3| 3| 3| 1| 3| 4| 3| 4| 3| 3| 4| 1| 0| 7| 4| 4| 4| 5| 4| 3| 2| 6| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Follicular Cell, Hyperplasia | 2 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + + + M + + M M M + M M + M + + M I +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M M + M M + M M A + + + + M + M + M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + I + M M + + M + + + + + + + M + + + + + + +|
Inflammation, Chronic | 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 2 3 3 3 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | M + + + M M + + + + + + A M M M + + M M M M + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 4| 7| 7| 7| 7| 7| 5| 5| 5| 7| 5| 7| 5| 7| 7| 5| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 1| 1| 1| 3| 3| 3| 3| 3| 4| 6| 2| 3| 2| 3| 5| 3| 3| 5| 3| 1| 5| 3|
| 3| 3| 3| 1| 3| 4| 3| 4| 3| 3| 4| 1| 0| 7| 4| 4| 4| 5| 4| 3| 2| 6| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + I + +|
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Diffuse, | |
Histiocyte | 2 1 2 2 1 1 1 1 3 |
Infiltration Cellular, Focal, | |
Histiocyte | 3 4 3 2 4 2 3 1 3 2 4 2 |
Inflammation, Chronic | 3 3 2 |
Alveolar Epithelium, Hyperplasia | 3 2 |
Bronchus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | 2 2|
Olfactory Epithelium, Atrophy | 2 2 2 2 1 2 1 1 2 1 2 1 2 2 2 1 2 2 3 2 1 3 3|
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Olfactory Epithelium, Hyperplasia | 1 1 1 1 |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Degeneration | |
Hemorrhage | |
Inflammation | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 4| 7| 7| 7| 7| 7| 5| 5| 5| 7| 5| 7| 5| 7| 7| 5| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 1| 1| 1| 3| 3| 3| 3| 3| 4| 6| 2| 3| 2| 3| 5| 3| 3| 5| 3| 1| 5| 3|
| 3| 3| 3| 1| 3| 4| 3| 4| 3| 3| 4| 1| 0| 7| 4| 4| 4| 5| 4| 3| 2| 6| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | |
Infiltration Cellular, Mixed Cell | 2 2 |
Mineralization | |
Nephropathy | 3 2 2 3 1 |
Glomerulus, Amyloid Deposition | 2 2 |
Medulla, Inflammation, Chronic | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
Inflammation | 4 3 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 5| 6| 5| 7| 6| 5| 5| 6| 3| 5| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 5| 4| 1| 7| 8| 3| 1| 3| 7| 5| 2| 5| 3| 0| 6| 6| 3| 9| 6| 3| 3| |
| 2| 4| 3| 4| 2| 9| 8| 3| 6| 3| 8| 3| 8| 5| 2| 5| 3| 8| 6| 1| 9| 9| 1| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + + A + + + + M + M + + M + M + +| 38 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + A + + + + + + A + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + A + + + + + + A + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + A + + + + A + A + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2| 1 2.0|
Eosinophilic Focus | X X | 2 |
Inflammation, Chronic | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 2 1 1 1 1| 39 1.3|
Karyomegaly | 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 2 3 3 | 43 2.7|
Mitotic Alteration | | 1 3.0|
Necrosis, Focal | 2| 1 2.0|
Regeneration | 3 3 3 3 3 2 2 3 3 3 3 3 3 3 4 3 3 2 | 38 2.8|
Bile Duct, Hyperplasia | 4 2 | 4 2.5|
Oval Cell, Hyperplasia | 3 3 3 3 3 1 3 3 4 2 3 3 3 3 3 3 3 3 1 3 3 | 44 2.7|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation, Chronic | | 1 2.0|
Artery, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 | 2 3.0|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 | 1 1.0|
Atrium, Thrombosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 5| 6| 5| 7| 6| 5| 5| 6| 3| 5| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 5| 4| 1| 7| 8| 3| 1| 3| 7| 5| 2| 5| 3| 0| 6| 6| 3| 9| 6| 3| 3| |
| 2| 4| 3| 4| 2| 9| 8| 3| 6| 3| 8| 3| 8| 5| 2| 5| 3| 8| 6| 1| 9| 9| 1| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 | 5 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + M + M M M M M M + M M + M + + + + M M +| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 1 1 2 1 2 1| 10 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 3 | 1 3.0|
Inflammation, Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Cyst | | 1 2.0|
Inflammation, Chronic | 1 3 1 | 5 1.4|
__________________________________________________________________________|____________|
Prostate | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + + M M M M M + + + + M M M + M M + + M M + +| 25 |
Infiltration Cellular, Histiocyte | 3| 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + M + + M + M + I + + + M M + + + M + M + +| 31 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + M + + + + + + + + + + + + + +| 47 |
Hemorrhage | 3 3 | 3 3.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + + + I M + + M + M M M + M + + + + M M| 35 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 5| 6| 5| 7| 6| 5| 5| 6| 3| 5| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 5| 4| 1| 7| 8| 3| 1| 3| 7| 5| 2| 5| 3| 0| 6| 6| 3| 9| 6| 3| 3| |
| 2| 4| 3| 4| 2| 9| 8| 3| 6| 3| 8| 3| 8| 5| 2| 5| 3| 8| 6| 1| 9| 9| 1| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 3 3 | 14 2.9|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M M M M M + + M + + + + + + M + + M + + M + + M +| 28 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 2 2.0|
Epidermis, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fracture | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 44 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Infiltration Cellular, Diffuse, | | |
Histiocyte | 1 | 10 1.5|
Infiltration Cellular, Focal, | | |
Histiocyte | 1 3 4 3 2| 17 2.7|
Inflammation, Chronic | | 3 2.7|
Alveolar Epithelium, Hyperplasia | 2 2 | 4 2.3|
Bronchus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | 1 3 3 2| 6 2.2|
Olfactory Epithelium, Atrophy | 2 2 2 1 2 1 1 2 3 2 2 2 2 1 1 2 1 2 1 3 2 2 1 3 3| 48 1.8|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 3 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05156-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/03/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:24:25
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 5| 6| 5| 7| 6| 5| 5| 6| 3| 5| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 5| 4| 1| 7| 8| 3| 1| 3| 7| 5| 2| 5| 3| 0| 6| 6| 3| 9| 6| 3| 3| |
| 2| 4| 3| 4| 2| 9| 8| 3| 6| 3| 8| 3| 8| 5| 2| 5| 3| 8| 6| 1| 9| 9| 1| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Hyperplasia | 1 1 1 1 1 1 | 10 1.0|
Olfactory Epithelium, Metaplasia | 2 3| 2 2.5|
Respiratory Epithelium, Degeneration,| | |
Hyaline | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Degeneration | 4 | 1 4.0|
Hemorrhage | 4 | 1 4.0|
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + +| 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Infiltration Cellular, Mixed Cell | 1 | 3 1.7|
Mineralization | 1 | 1 1.0|
Nephropathy | 2 2 2 2 | 9 2.1|
Glomerulus, Amyloid Deposition | | 2 2.0|
Medulla, Inflammation, Chronic | 4 | 1 4.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation | 3 | 3 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
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---------- END OF REPORT ----------
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