TDMS Study 05156-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest COBALT SULFATE HEPTAHYDRATE DATE: 07/03/96
EXPERIMENT: 05156 TEST: 06 TIME: 11:52:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-05287 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61530B
PATHOLOGIST: MELLICK, P. CAS: 10026-24-1
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest COBALT SULFATE HEPTAHYDRATE DATE: 07/03/96
EXPERIMENT: 05156 TEST: 06 TIME: 11:52:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05287 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61530B
PATHOLOGIST: MELLICK, P. CAS: 10026-24-1
COBALT SULFATE HEPTAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 1 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 449 470 482 486 516 533 541 541 555 575 |
| 579 600 600 611 640 643 649 651 652 652 |
| 676 685 686 686 708 711 725 |
| CENSORED DEATHS |
| 680 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.3 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 460 501 541 583 599 611 614 617 649 652 |
| 653 666 666 685 687 690 709 720 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 440 483 505 510 523 534 548 555 560 561 |
| 597 610 639 645 645 652 653 670 681 681 |
| 687 699 705 706 708 709 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
COBALT SULFATE HEPTAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 3.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 1 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 399 414 502 524 527 533 536 541 552 555 |
| 555 555 560 561 561 566 608 611 613 618 |
| 618 622 639 649 652 653 673 686 713 |
| CENSORED DEATHS |
| 678 |
| |
==================================================================================
COBALT SULFATE HEPTAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 94.0 84.0 74.0 60.0 45.6 |
| | |
| | |
|0.3 | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 90.0 78.0 62.0 |
|MG/M3 | |
| | |
|1.0 | 100.0 100.0 100.0 100.0 100.0 96.0 88.0 78.0 66.0 48.0 |
|MG/M3 | |
| | |
|3.0 | 100.0 100.0 100.0 100.0 96.0 96.0 84.0 68.0 48.0 41.8 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.3 1.0 3.0 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 45.6% 62.0% 48.0% 41.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.104 P=0.088N P=0.861N P=0.577 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 603.8 633.1 611.8 579.2 |
|NATURAL DEATHS (C) | (15.5) (16.6) (15.9) (13.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 662.2 695.0 670.0 642.7 |
|(STANDARD ERROR) | (12.3) ( 9.3) (11.9) (13.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
COBALT SULFATE HEPTAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 225 531 559 583 596 609 619 620 639 643 |
| 652 656 677 699 699 713 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.3 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 481 593 596 649 652 664 666 666 666 693 |
| 720 726 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 9 495 505 524 548 569 622 640 649 659 |
| 666 666 667 674 703 709 720 733 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
COBALT SULFATE HEPTAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 3.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 356 429 443 462 484 536 539 606 609 611 |
| 639 667 675 680 686 692 706 712 717 719 |
| 726 732 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
COBALT SULFATE HEPTAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.0 98.0 98.0 98.0 96.0 90.0 76.0 68.0 |
| | |
| | |
|0.3 | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 94.0 88.0 74.0 |
|MG/M3 | |
| | |
|1.0 | 98.0 98.0 98.0 98.0 98.0 98.0 92.0 88.0 80.0 64.0 |
|MG/M3 | |
| | |
|3.0 | 100.0 100.0 100.0 98.0 98.0 90.0 86.0 86.0 78.0 56.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.3 1.0 3.0 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 74.0% 64.0% 56.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.102 P=0.529N P=0.855 P=0.327 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 607.5 653.8 597.7 610.3 |
|NATURAL DEATHS (C) | (28.5) (18.6) (38.8) (24.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 693.5 713.1 684.9 679.6 |
|(STANDARD ERROR) | (12.3) ( 6.9) (16.6) (13.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
COBALT SULFATE HEPTAHYDRATE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.3 MG/M3 = 2
1.0 MG/M3 = 3
3.0 MG/M3 = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 12
| 4 4 3 12 13 2
| 4 111 23 4 2 2
| 1 31 34 2 2
P 90 + 1 341 2 2
E | 113
R | 4131 22 2
C | 413 1 22
E 80 + 3 3
N | 1 1 3 2 2
T | 44 1 1 33 2 2
| 1 1 22
S 70 + 33
U | 4 4 11 2 2
R | 44 11 3 3 222
V | 44 2 2
I 60 + 1 133
V | 1133
A | 4 44 33
L | 44 1 31
50 +
| 4 4 1 1 3
| 44 4 1 1
| 4 4
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 29 obs hidden.
COBALT SULFATE HEPTAHYDRATE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.3 MG/M3 = 2
1.0 MG/M3 = 3
3.0 MG/M3 = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 4 2
|
| 3 1 4 4 2 3 1 2
| 4 4 3 3 1 1 22
95 +
| 4 4 3 3 1 1 2 2
| 4 4 3 3 1 1 22
|
90 + 4 4 3 3 11 2 2
|
P | 3 1 1 22
E | 4 4 3 3
R 85 +
C | 1 13
E | 44 3 32 2
N |
T 80 + 4 1 1 33 2 2
|
S | 4 4 22
U | 1 41
R 75 +
V | 314 1 2 2
I | 3 3
V |
A 70 + 44131
L |
| 4 413 1
| 443 3
65 +
| 44 3
|
|
60 + 44
|
| 4 4
| 4
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.