TDMS Study 05156-05 Pathology Tables
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51 CORE STUDY Facility: Battelle Northwest Chemical CAS #: 10026-24-1 Lock Date: 07/15/94 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 19 20 20 17 Natural Death 3 4 4 3 Survivors Terminal Sacrifice 28 25 26 30 Other 1 Animals Examined Microscopically 50 49 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (49) (50) (50) Inflammation, Suppurative 1 (2%) Intestine Large, Cecum (48) (45) (47) (47) Necrosis 1 (2%) Liver (50) (49) (50) (49) Angiectasis 6 (12%) 4 (8%) 1 (2%) 2 (4%) Basophilic Focus 39 (78%) 37 (76%) 45 (90%) 41 (84%) Clear Cell Focus 7 (14%) 6 (12%) 5 (10%) 11 (22%) Cyst 1 (2%) Degeneration, Fatty 8 (16%) 9 (18%) 8 (16%) 2 (4%) Eosinophilic Focus 4 (8%) 1 (2%) 1 (2%) 2 (4%) Hepatodiaphragmatic Nodule 6 (12%) 6 (12%) 8 (16%) 4 (8%) Inflammation, Chronic Active 1 (2%) Mixed Cell Focus 11 (22%) 11 (22%) 18 (36%) 15 (31%) Necrosis 1 (2%) Regeneration 1 (2%) 2 (4%) Thrombosis 1 (2%) Bile Duct, Hyperplasia 5 (10%) 6 (12%) 9 (18%) 7 (14%) Centrilobular, Necrosis 5 (10%) 6 (12%) 7 (14%) 5 (10%) Mesentery (5) (8) (6) (13) Inflammation, Chronic Active 1 (8%) Artery, Inflammation, Chronic Active 1 (13%) Fat, Necrosis 5 (100%) 6 (75%) 6 (100%) 12 (92%) Pancreas (49) (49) (50) (48) Atrophy 22 (45%) 11 (22%) 16 (32%) 16 (33%) Basophilic Focus 3 (6%) Hyperplasia 1 (2%) Artery, Inflammation 1 (2%) Salivary Glands (50) (49) (50) (50) Atrophy 3 (6%) 4 (8%) 1 (2%) Stomach, Forestomach (50) (49) (50) (50) Hyperplasia, Basal Cell 1 (2%) Hyperplasia, Squamous 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Necrosis 3 (6%) 2 (4%) 1 (2%) 1 (2%) Stomach, Glandular (49) (49) (49) (48) Mineralization 1 (2%) 1 (2%) 1 (2%) 1 (2%) Necrosis 4 (8%) 1 (2%) Tooth (2) (1) Developmental Malformation 1 (50%) Inflammation, Chronic Active 1 (50%) 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) Aorta, Inflammation, Chronic Active 1 (100%) Heart (50) (49) (50) (50) Cardiomyopathy 29 (58%) 24 (49%) 29 (58%) 23 (46%) Atrium, Thrombosis 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (49) (49) (50) (49) Hyperplasia 21 (43%) 21 (43%) 25 (50%) 23 (47%) Hypertrophy 5 (10%) 3 (6%) 8 (16%) 9 (18%) Necrosis 1 (2%) Vacuolization Cytoplasmic 11 (22%) 5 (10%) 10 (20%) 12 (24%) Adrenal Medulla (48) (49) (50) (48) Hyperplasia 8 (17%) 7 (14%) 11 (22%) 13 (27%) Pituitary Gland (50) (49) (50) (49) Pars Distalis, Angiectasis 2 (4%) Pars Distalis, Cyst 1 (2%) Pars Distalis, Hyperplasia 5 (10%) 5 (10%) 8 (16%) 5 (10%) Thyroid Gland (49) (49) (50) (48) C-Cell, Hyperplasia 37 (76%) 42 (86%) 37 (74%) 38 (79%) Follicular Cell, Hyperplasia 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (50) (48) (48) (49) Hyperplasia 2 (4%) 1 (2%) 1 (2%) 2 (4%) Inflammation, Chronic Active 2 (4%) 6 (13%) 2 (4%) 6 (12%) Ovary (50) (49) (50) (49) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Cyst 5 (10%) 1 (2%) 3 (6%) Uterus (50) (49) (50) (49) Hydrometra 2 (4%) Cervix, Hypertrophy 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (49) (50) (50) Atrophy 2 (4%) 1 (2%) Hyperplasia, Histiocytic 1 (2%) 1 (2%) Lymph Node (2) (3) (3) (2) Renal, Hemorrhage 1 (33%) Lymph Node, Mandibular (44) (40) (47) (45) Infiltration Cellular, Plasma Cell 1 (2%) Lymph Node, Mesenteric (49) (49) (50) (48) Hemorrhage 1 (2%) 1 (2%) Infiltration Cellular, Eosinophil 1 (2%) Lymph Node, Mediastinal (43) (38) (43) (45) Hemorrhage 1 (2%) 1 (2%) Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%) Spleen (49) (48) (50) (49) Accessory Spleen 1 (2%) 2 (4%) Fibrosis 4 (8%) 2 (4%) Hematopoietic Cell Proliferation 3 (6%) 2 (4%) 4 (8%) 3 (6%) Hemorrhage 2 (4%) 3 (6%) 1 (2%) Hyperplasia, Focal 1 (2%) Necrosis 1 (2%) Thrombosis 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (49) (50) (49) Galactocele 2 (4%) 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) Skin (50) (49) (50) (50) Hyperkeratosis 1 (2%) Inflammation, Chronic 1 (2%) Inflammation, Chronic Active 4 (8%) 3 (6%) 3 (6%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (49) (50) (50) Hyperostosis 4 (8%) 5 (10%) 5 (10%) 3 (6%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (49) (50) (50) Gliosis 1 (2%) Hemorrhage 2 (4%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (49) (50) (50) Epiglottis, Metaplasia, Squamous 1 (2%) 22 (45%) 39 (78%) 48 (96%) Lung (50) (49) (50) (50) Congestion, Chronic 1 (2%) Cyst 1 (2%) Metaplasia, Osseous 1 (2%) Metaplasia, Squamous 1 (2%) 8 (16%) 3 (6%) Pigmentation, Hemosiderin 1 (2%) Proteinosis 36 (73%) 49 (98%) 49 (98%) Alveolar Epithelium, Hyperplasia 15 (30%) 7 (14%) 20 (40%) 33 (66%) Alveolar Epithelium, Hyperplasia, Atypical 3 (6%) 5 (10%) Alveolar Epithelium, Metaplasia 2 (4%) 47 (96%) 50 (100%) 49 (98%) Alveolus, Inflammation, Granulomatous 9 (18%) 47 (96%) 50 (100%) 49 (98%) Interstitium, Fibrosis 7 (14%) 47 (96%) 50 (100%) 49 (98%) Perivascular, Inflammation, Chronic Active 1 (2%) Nose (50) (49) (50) (50) Inflammation, Suppurative 6 (12%) 10 (20%) 2 (4%) 4 (8%) Thrombosis 4 (8%) 4 (8%) 3 (6%) 2 (4%) Lateral Wall, Hyperplasia 1 (2%) 8 (16%) 26 (52%) 38 (76%) Lateral Wall, Metaplasia, Squamous 1 (2%) 1 (2%) 4 (8%) 10 (20%) Nasolacrimal Duct, Metaplasia, Squamous 1 (2%) Olfactory Epithelium, Atrophy 5 (10%) 29 (59%) 46 (92%) 47 (94%) Olfactory Epithelium, Metaplasia 2 (4%) 2 (4%) 3 (6%) 40 (80%) Respiratory Epithelium, Hyperplasia, Focal 1 (2%) Respiratory Epithelium, Metaplasia, Squamous 2 (4%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (5) (3) (3) Cataract 1 (100%) 4 (80%) 3 (100%) 2 (67%) Cornea, Edema 1 (20%) Retina, Atrophy 1 (100%) 4 (80%) 3 (100%) 1 (33%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (49) (50) (48) Hyperplasia, Stromal 1 (2%) Infarct 1 (2%) 2 (4%) 2 (4%) Nephropathy 47 (96%) 48 (98%) 45 (90%) 48 (100%) Renal Tubule, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 30 34 26 34 Natural Death 3 1 3 1 Survivors Terminal Sacrifice 17 15 21 15 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (50) (50) (50) Inflammation, Suppurative 1 (2%) Intestine Small, Jejunum (49) (49) (47) (49) Inflammation, Chronic Active 1 (2%) Liver (50) (50) (48) (50) Angiectasis 5 (10%) 1 (2%) 1 (2%) Basophilic Focus 13 (26%) 16 (32%) 23 (48%) 21 (42%) Clear Cell Focus 8 (16%) 5 (10%) 8 (17%) 6 (12%) Degeneration, Cystic 10 (20%) 11 (22%) 16 (33%) 10 (20%) Degeneration, Fatty 6 (12%) 5 (10%) 5 (10%) 6 (12%) Eosinophilic Focus 2 (4%) 3 (6%) 5 (10%) Hepatodiaphragmatic Nodule 1 (2%) 4 (8%) 4 (8%) 6 (12%) Mixed Cell Focus 3 (6%) 3 (6%) 4 (8%) 5 (10%) Necrosis 2 (4%) 1 (2%) 1 (2%) Regeneration 3 (6%) 1 (2%) 1 (2%) 1 (2%) Thrombosis 1 (2%) 1 (2%) Bile Duct, Hyperplasia 41 (82%) 42 (84%) 34 (71%) 35 (70%) Centrilobular, Necrosis 17 (34%) 19 (38%) 5 (10%) 11 (22%) Mesentery (21) (14) (11) (14) Fat, Hemorrhage 1 (5%) 1 (9%) Fat, Necrosis 20 (95%) 11 (79%) 9 (82%) 13 (93%) Pancreas (50) (50) (48) (50) Angiectasis 1 (2%) Atrophy 25 (50%) 25 (50%) 20 (42%) 28 (56%) Basophilic Focus 3 (6%) 2 (4%) 6 (13%) 3 (6%) Hyperplasia 2 (4%) 1 (2%) 4 (8%) 1 (2%) Metaplasia, Hepatocyte 1 (2%) Salivary Glands (50) (50) (50) (50) Atrophy 2 (4%) 2 (4%) 1 (2%) Stomach, Forestomach (50) (50) (49) (50) Hyperplasia, Basal Cell 1 (2%) Hyperplasia, Squamous 1 (2%) Necrosis 6 (12%) 5 (10%) 10 (20%) 3 (6%) Stomach, Glandular (50) (50) (48) (50) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Inflammation, Acute 1 (2%) Mineralization 1 (2%) 2 (4%) 1 (2%) 1 (2%) Necrosis 3 (6%) 2 (4%) 5 (10%) 2 (4%) Tongue (1) (2) Hyperplasia, Squamous 1 (100%) 1 (50%) Epithelium, Cyst 1 (50%) Tooth (1) (1) Developmental Malformation 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) Aorta, Mineralization 1 (100%) Heart (50) (50) (50) (50) Cardiomyopathy 38 (76%) 46 (92%) 45 (90%) 38 (76%) Atrium, Thrombosis 2 (4%) 4 (8%) 1 (2%) 4 (8%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (48) (50) Hyperplasia 26 (52%) 24 (48%) 26 (54%) 24 (48%) Hypertrophy 2 (4%) 5 (10%) 5 (10%) 5 (10%) Necrosis 2 (4%) 1 (2%) 3 (6%) Thrombosis 1 (2%) Vacuolization Cytoplasmic 6 (12%) 4 (8%) 3 (6%) 3 (6%) Adrenal Medulla (50) (50) (49) (50) Cyst 1 (2%) Hyperplasia 34 (68%) 23 (46%) 29 (59%) 30 (60%) Islets, Pancreatic (50) (50) (48) (50) Hyperplasia 1 (2%) Parathyroid Gland (48) (48) (49) (49) Hyperplasia 1 (2%) 1 (2%) 3 (6%) 1 (2%) Pituitary Gland (49) (49) (50) (49) Pars Distalis, Hyperplasia 4 (8%) 5 (10%) 4 (8%) 5 (10%) Thyroid Gland (49) (50) (48) (50) C-Cell, Hyperplasia 31 (63%) 32 (64%) 32 (67%) 34 (68%) Follicular Cell, Hyperplasia 2 (4%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Granuloma Sperm 1 (2%) 3 (6%) Preputial Gland (50) (50) (49) (50) Hyperplasia 1 (2%) Inflammation, Chronic Active 11 (22%) 10 (20%) 3 (6%) 12 (24%) Prostate (50) (50) (49) (50) Hyperplasia 12 (24%) 8 (16%) 5 (10%) 9 (18%) Inflammation, Chronic Active 3 (6%) 4 (8%) 1 (2%) 1 (2%) Necrosis 1 (2%) Seminal Vesicle (50) (50) (49) (49) Inflammation, Chronic Active 1 (2%) Necrosis 1 (2%) Testes (50) (50) (50) (50) Atrophy 2 (4%) 4 (8%) 5 (10%) Artery, Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%) 3 (6%) Interstitial Cell, Hyperplasia 13 (26%) 10 (20%) 6 (12%) 10 (20%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (48) (50) Necrosis 1 (2%) Lymph Node (8) (9) (9) (9) Iliac, Ectasia 1 (11%) Iliac, Hemorrhage 1 (11%) Pancreatic, Ectasia 1 (11%) Renal, Hemorrhage 1 (11%) Lymph Node, Bronchial (45) (30) (41) (49) Inflammation, Suppurative 1 (2%) Lymph Node, Mandibular (46) (47) (47) (49) Infiltration Cellular, Plasma Cell 1 (2%) Lymph Node, Mediastinal (47) (46) (44) (49) Hemorrhage 1 (2%) 1 (2%) Spleen (50) (50) (49) (50) Accessory Spleen 1 (2%) 1 (2%) 1 (2%) 1 (2%) Depletion Cellular 1 (2%) Fibrosis 16 (32%) 16 (32%) 12 (24%) 13 (26%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%) Hyperplasia, Focal 1 (2%) Necrosis 2 (4%) 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (30) (34) (36) (38) Galactocele 2 (7%) 1 (3%) 1 (3%) Hyperplasia, Atypical 1 (3%) Skin (50) (48) (50) (50) Cyst Epithelial Inclusion 1 (2%) Inflammation, Chronic 3 (6%) 1 (2%) 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) 2 (4%) 3 (6%) Subcutaneous Tissue, Edema 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Fibrous Osteodystrophy 2 (4%) Hyperostosis 2 (4%) 2 (4%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Developmental Malformation 1 (2%) Gliosis 1 (2%) 1 (2%) 1 (2%) Mineralization 1 (2%) Necrosis 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (49) (48) (50) Epiglottis, Metaplasia, Squamous 10 (20%) 37 (77%) 50 (100%) Lung (50) (50) (48) (50) Cyst 1 (2%) Foreign Body 1 (2%) Hemorrhage 1 (2%) Hyperplasia, Atypical 1 (2%) 1 (2%) Infiltration Cellular, Histiocyte 1 (2%) 1 (2%) 1 (2%) Inflammation, Suppurative 1 (2%) Metaplasia, Squamous 1 (2%) 4 (8%) 2 (4%) Mineralization 1 (2%) Proteinosis 16 (32%) 40 (83%) 47 (94%) Thrombosis 1 (2%) 1 (2%) Alveolar Epithelium, Hyperplasia 9 (18%) 20 (40%) 20 (42%) 23 (46%) Alveolar Epithelium, Hyperplasia, Atypical 1 (2%) 2 (4%) 2 (4%) Alveolar Epithelium, Metaplasia 50 (100%) 48 (100%) 49 (98%) Alveolus, Inflammation, Granulomatous 2 (4%) 50 (100%) 48 (100%) 50 (100%) Artery, Mediastinum, Mineralization 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0 MG/M3 MG/M3 MG/M3 ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Bronchiole, Inflammation, Chronic 1 (2%) Interstitium, Fibrosis 1 (2%) 50 (100%) 48 (100%) 49 (98%) Mediastinum, Inflammation, Suppurative 1 (2%) Nose (50) (50) (49) (50) Inflammation, Chronic Active 1 (2%) Inflammation, Suppurative 4 (8%) 15 (30%) 5 (10%) 6 (12%) Metaplasia, Squamous 1 (2%) Thrombosis 14 (28%) 18 (36%) 3 (6%) 9 (18%) Glands, Cyst 1 (2%) Lateral Wall, Hyperplasia 2 (4%) 14 (28%) 21 (43%) 20 (40%) Lateral Wall, Inflammation 1 (2%) Lateral Wall, Metaplasia, Squamous 1 (2%) 3 (6%) 5 (10%) 8 (16%) Olfactory Epithelium, Atrophy 8 (16%) 24 (48%) 42 (86%) 48 (96%) Olfactory Epithelium, Metaplasia 5 (10%) 1 (2%) 5 (10%) 30 (60%) Respiratory Epithelium, Hyperplasia, Focal 6 (12%) 1 (2%) 3 (6%) 2 (4%) Respiratory Epithelium, Inflammation 4 (8%) 1 (2%) Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%) Trachea (50) (50) (48) (50) Mineralization 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (5) (1) (1) Cataract 5 (100%) 1 (100%) 1 (100%) Retina, Atrophy 5 (100%) 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (48) (50) Cyst 1 (2%) 1 (2%) Hydronephrosis 1 (2%) 1 (2%) Infarct 4 (8%) 1 (2%) 1 (2%) 3 (6%) Nephropathy 49 (98%) 49 (98%) 48 (100%) 50 (100%) Thrombosis 1 (2%) Papilla, Necrosis 1 (2%) Renal Tubule, Hyperplasia 2 (4%) 4 (8%) 2 (4%) 2 (4%) Urinary Bladder (50) (50) (48) (50) Necrosis 1 (2%) Transitional Epithelium, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 11 ------------------------------------------------------------ ---------- END OF REPORT ---------- 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