TDMS Study 05156-05 Pathology Tables
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 10026-24-1
Lock Date: 07/15/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 19 20 20 17
Natural Death 3 4 4 3
Survivors
Terminal Sacrifice 28 25 26 30
Other 1
Animals Examined Microscopically 50 49 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (49) (50) (50)
Inflammation, Suppurative 1 (2%)
Intestine Large, Cecum (48) (45) (47) (47)
Necrosis 1 (2%)
Liver (50) (49) (50) (49)
Angiectasis 6 (12%) 4 (8%) 1 (2%) 2 (4%)
Basophilic Focus 39 (78%) 37 (76%) 45 (90%) 41 (84%)
Clear Cell Focus 7 (14%) 6 (12%) 5 (10%) 11 (22%)
Cyst 1 (2%)
Degeneration, Fatty 8 (16%) 9 (18%) 8 (16%) 2 (4%)
Eosinophilic Focus 4 (8%) 1 (2%) 1 (2%) 2 (4%)
Hepatodiaphragmatic Nodule 6 (12%) 6 (12%) 8 (16%) 4 (8%)
Inflammation, Chronic Active 1 (2%)
Mixed Cell Focus 11 (22%) 11 (22%) 18 (36%) 15 (31%)
Necrosis 1 (2%)
Regeneration 1 (2%) 2 (4%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 5 (10%) 6 (12%) 9 (18%) 7 (14%)
Centrilobular, Necrosis 5 (10%) 6 (12%) 7 (14%) 5 (10%)
Mesentery (5) (8) (6) (13)
Inflammation, Chronic Active 1 (8%)
Artery, Inflammation, Chronic Active 1 (13%)
Fat, Necrosis 5 (100%) 6 (75%) 6 (100%) 12 (92%)
Pancreas (49) (49) (50) (48)
Atrophy 22 (45%) 11 (22%) 16 (32%) 16 (33%)
Basophilic Focus 3 (6%)
Hyperplasia 1 (2%)
Artery, Inflammation 1 (2%)
Salivary Glands (50) (49) (50) (50)
Atrophy 3 (6%) 4 (8%) 1 (2%)
Stomach, Forestomach (50) (49) (50) (50)
Hyperplasia, Basal Cell 1 (2%)
Hyperplasia, Squamous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Stomach, Glandular (49) (49) (49) (48)
Mineralization 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Necrosis 4 (8%) 1 (2%)
Tooth (2) (1)
Developmental Malformation 1 (50%)
Inflammation, Chronic Active 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Inflammation, Chronic Active 1 (100%)
Heart (50) (49) (50) (50)
Cardiomyopathy 29 (58%) 24 (49%) 29 (58%) 23 (46%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (49) (50) (49)
Hyperplasia 21 (43%) 21 (43%) 25 (50%) 23 (47%)
Hypertrophy 5 (10%) 3 (6%) 8 (16%) 9 (18%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 11 (22%) 5 (10%) 10 (20%) 12 (24%)
Adrenal Medulla (48) (49) (50) (48)
Hyperplasia 8 (17%) 7 (14%) 11 (22%) 13 (27%)
Pituitary Gland (50) (49) (50) (49)
Pars Distalis, Angiectasis 2 (4%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 5 (10%) 5 (10%) 8 (16%) 5 (10%)
Thyroid Gland (49) (49) (50) (48)
C-Cell, Hyperplasia 37 (76%) 42 (86%) 37 (74%) 38 (79%)
Follicular Cell, Hyperplasia 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (48) (48) (49)
Hyperplasia 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic Active 2 (4%) 6 (13%) 2 (4%) 6 (12%)
Ovary (50) (49) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Cyst 5 (10%) 1 (2%) 3 (6%)
Uterus (50) (49) (50) (49)
Hydrometra 2 (4%)
Cervix, Hypertrophy 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (50) (50)
Atrophy 2 (4%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%) 1 (2%)
Lymph Node (2) (3) (3) (2)
Renal, Hemorrhage 1 (33%)
Lymph Node, Mandibular (44) (40) (47) (45)
Infiltration Cellular, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (49) (49) (50) (48)
Hemorrhage 1 (2%) 1 (2%)
Infiltration Cellular, Eosinophil 1 (2%)
Lymph Node, Mediastinal (43) (38) (43) (45)
Hemorrhage 1 (2%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%)
Spleen (49) (48) (50) (49)
Accessory Spleen 1 (2%) 2 (4%)
Fibrosis 4 (8%) 2 (4%)
Hematopoietic Cell Proliferation 3 (6%) 2 (4%) 4 (8%) 3 (6%)
Hemorrhage 2 (4%) 3 (6%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (50) (49)
Galactocele 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Skin (50) (49) (50) (50)
Hyperkeratosis 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 4 (8%) 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (50) (50)
Hyperostosis 4 (8%) 5 (10%) 5 (10%) 3 (6%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Gliosis 1 (2%)
Hemorrhage 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (50) (50)
Epiglottis, Metaplasia, Squamous 1 (2%) 22 (45%) 39 (78%) 48 (96%)
Lung (50) (49) (50) (50)
Congestion, Chronic 1 (2%)
Cyst 1 (2%)
Metaplasia, Osseous 1 (2%)
Metaplasia, Squamous 1 (2%) 8 (16%) 3 (6%)
Pigmentation, Hemosiderin 1 (2%)
Proteinosis 36 (73%) 49 (98%) 49 (98%)
Alveolar Epithelium, Hyperplasia 15 (30%) 7 (14%) 20 (40%) 33 (66%)
Alveolar Epithelium, Hyperplasia, Atypical 3 (6%) 5 (10%)
Alveolar Epithelium, Metaplasia 2 (4%) 47 (96%) 50 (100%) 49 (98%)
Alveolus, Inflammation, Granulomatous 9 (18%) 47 (96%) 50 (100%) 49 (98%)
Interstitium, Fibrosis 7 (14%) 47 (96%) 50 (100%) 49 (98%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Nose (50) (49) (50) (50)
Inflammation, Suppurative 6 (12%) 10 (20%) 2 (4%) 4 (8%)
Thrombosis 4 (8%) 4 (8%) 3 (6%) 2 (4%)
Lateral Wall, Hyperplasia 1 (2%) 8 (16%) 26 (52%) 38 (76%)
Lateral Wall, Metaplasia, Squamous 1 (2%) 1 (2%) 4 (8%) 10 (20%)
Nasolacrimal Duct, Metaplasia, Squamous 1 (2%)
Olfactory Epithelium, Atrophy 5 (10%) 29 (59%) 46 (92%) 47 (94%)
Olfactory Epithelium, Metaplasia 2 (4%) 2 (4%) 3 (6%) 40 (80%)
Respiratory Epithelium, Hyperplasia, Focal 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (5) (3) (3)
Cataract 1 (100%) 4 (80%) 3 (100%) 2 (67%)
Cornea, Edema 1 (20%)
Retina, Atrophy 1 (100%) 4 (80%) 3 (100%) 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (49) (50) (48)
Hyperplasia, Stromal 1 (2%)
Infarct 1 (2%) 2 (4%) 2 (4%)
Nephropathy 47 (96%) 48 (98%) 45 (90%) 48 (100%)
Renal Tubule, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 30 34 26 34
Natural Death 3 1 3 1
Survivors
Terminal Sacrifice 17 15 21 15
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
Intestine Small, Jejunum (49) (49) (47) (49)
Inflammation, Chronic Active 1 (2%)
Liver (50) (50) (48) (50)
Angiectasis 5 (10%) 1 (2%) 1 (2%)
Basophilic Focus 13 (26%) 16 (32%) 23 (48%) 21 (42%)
Clear Cell Focus 8 (16%) 5 (10%) 8 (17%) 6 (12%)
Degeneration, Cystic 10 (20%) 11 (22%) 16 (33%) 10 (20%)
Degeneration, Fatty 6 (12%) 5 (10%) 5 (10%) 6 (12%)
Eosinophilic Focus 2 (4%) 3 (6%) 5 (10%)
Hepatodiaphragmatic Nodule 1 (2%) 4 (8%) 4 (8%) 6 (12%)
Mixed Cell Focus 3 (6%) 3 (6%) 4 (8%) 5 (10%)
Necrosis 2 (4%) 1 (2%) 1 (2%)
Regeneration 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 41 (82%) 42 (84%) 34 (71%) 35 (70%)
Centrilobular, Necrosis 17 (34%) 19 (38%) 5 (10%) 11 (22%)
Mesentery (21) (14) (11) (14)
Fat, Hemorrhage 1 (5%) 1 (9%)
Fat, Necrosis 20 (95%) 11 (79%) 9 (82%) 13 (93%)
Pancreas (50) (50) (48) (50)
Angiectasis 1 (2%)
Atrophy 25 (50%) 25 (50%) 20 (42%) 28 (56%)
Basophilic Focus 3 (6%) 2 (4%) 6 (13%) 3 (6%)
Hyperplasia 2 (4%) 1 (2%) 4 (8%) 1 (2%)
Metaplasia, Hepatocyte 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 2 (4%) 2 (4%) 1 (2%)
Stomach, Forestomach (50) (50) (49) (50)
Hyperplasia, Basal Cell 1 (2%)
Hyperplasia, Squamous 1 (2%)
Necrosis 6 (12%) 5 (10%) 10 (20%) 3 (6%)
Stomach, Glandular (50) (50) (48) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Acute 1 (2%)
Mineralization 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Necrosis 3 (6%) 2 (4%) 5 (10%) 2 (4%)
Tongue (1) (2)
Hyperplasia, Squamous 1 (100%) 1 (50%)
Epithelium, Cyst 1 (50%)
Tooth (1) (1)
Developmental Malformation 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Mineralization 1 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 38 (76%) 46 (92%) 45 (90%) 38 (76%)
Atrium, Thrombosis 2 (4%) 4 (8%) 1 (2%) 4 (8%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (48) (50)
Hyperplasia 26 (52%) 24 (48%) 26 (54%) 24 (48%)
Hypertrophy 2 (4%) 5 (10%) 5 (10%) 5 (10%)
Necrosis 2 (4%) 1 (2%) 3 (6%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 6 (12%) 4 (8%) 3 (6%) 3 (6%)
Adrenal Medulla (50) (50) (49) (50)
Cyst 1 (2%)
Hyperplasia 34 (68%) 23 (46%) 29 (59%) 30 (60%)
Islets, Pancreatic (50) (50) (48) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (48) (48) (49) (49)
Hyperplasia 1 (2%) 1 (2%) 3 (6%) 1 (2%)
Pituitary Gland (49) (49) (50) (49)
Pars Distalis, Hyperplasia 4 (8%) 5 (10%) 4 (8%) 5 (10%)
Thyroid Gland (49) (50) (48) (50)
C-Cell, Hyperplasia 31 (63%) 32 (64%) 32 (67%) 34 (68%)
Follicular Cell, Hyperplasia 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%) 3 (6%)
Preputial Gland (50) (50) (49) (50)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 11 (22%) 10 (20%) 3 (6%) 12 (24%)
Prostate (50) (50) (49) (50)
Hyperplasia 12 (24%) 8 (16%) 5 (10%) 9 (18%)
Inflammation, Chronic Active 3 (6%) 4 (8%) 1 (2%) 1 (2%)
Necrosis 1 (2%)
Seminal Vesicle (50) (50) (49) (49)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 2 (4%) 4 (8%) 5 (10%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%) 3 (6%)
Interstitial Cell, Hyperplasia 13 (26%) 10 (20%) 6 (12%) 10 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (48) (50)
Necrosis 1 (2%)
Lymph Node (8) (9) (9) (9)
Iliac, Ectasia 1 (11%)
Iliac, Hemorrhage 1 (11%)
Pancreatic, Ectasia 1 (11%)
Renal, Hemorrhage 1 (11%)
Lymph Node, Bronchial (45) (30) (41) (49)
Inflammation, Suppurative 1 (2%)
Lymph Node, Mandibular (46) (47) (47) (49)
Infiltration Cellular, Plasma Cell 1 (2%)
Lymph Node, Mediastinal (47) (46) (44) (49)
Hemorrhage 1 (2%) 1 (2%)
Spleen (50) (50) (49) (50)
Accessory Spleen 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Depletion Cellular 1 (2%)
Fibrosis 16 (32%) 16 (32%) 12 (24%) 13 (26%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Necrosis 2 (4%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (30) (34) (36) (38)
Galactocele 2 (7%) 1 (3%) 1 (3%)
Hyperplasia, Atypical 1 (3%)
Skin (50) (48) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 3 (6%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 2 (4%)
Hyperostosis 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Developmental Malformation 1 (2%)
Gliosis 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Necrosis 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (48) (50)
Epiglottis, Metaplasia, Squamous 10 (20%) 37 (77%) 50 (100%)
Lung (50) (50) (48) (50)
Cyst 1 (2%)
Foreign Body 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Atypical 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Squamous 1 (2%) 4 (8%) 2 (4%)
Mineralization 1 (2%)
Proteinosis 16 (32%) 40 (83%) 47 (94%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 9 (18%) 20 (40%) 20 (42%) 23 (46%)
Alveolar Epithelium, Hyperplasia, Atypical 1 (2%) 2 (4%) 2 (4%)
Alveolar Epithelium, Metaplasia 50 (100%) 48 (100%) 49 (98%)
Alveolus, Inflammation, Granulomatous 2 (4%) 50 (100%) 48 (100%) 50 (100%)
Artery, Mediastinum, Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:33:51
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Bronchiole, Inflammation, Chronic 1 (2%)
Interstitium, Fibrosis 1 (2%) 50 (100%) 48 (100%) 49 (98%)
Mediastinum, Inflammation, Suppurative 1 (2%)
Nose (50) (50) (49) (50)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 4 (8%) 15 (30%) 5 (10%) 6 (12%)
Metaplasia, Squamous 1 (2%)
Thrombosis 14 (28%) 18 (36%) 3 (6%) 9 (18%)
Glands, Cyst 1 (2%)
Lateral Wall, Hyperplasia 2 (4%) 14 (28%) 21 (43%) 20 (40%)
Lateral Wall, Inflammation 1 (2%)
Lateral Wall, Metaplasia, Squamous 1 (2%) 3 (6%) 5 (10%) 8 (16%)
Olfactory Epithelium, Atrophy 8 (16%) 24 (48%) 42 (86%) 48 (96%)
Olfactory Epithelium, Metaplasia 5 (10%) 1 (2%) 5 (10%) 30 (60%)
Respiratory Epithelium, Hyperplasia, Focal 6 (12%) 1 (2%) 3 (6%) 2 (4%)
Respiratory Epithelium, Inflammation 4 (8%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%)
Trachea (50) (50) (48) (50)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5) (1) (1)
Cataract 5 (100%) 1 (100%) 1 (100%)
Retina, Atrophy 5 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (48) (50)
Cyst 1 (2%) 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Infarct 4 (8%) 1 (2%) 1 (2%) 3 (6%)
Nephropathy 49 (98%) 49 (98%) 48 (100%) 50 (100%)
Thrombosis 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Hyperplasia 2 (4%) 4 (8%) 2 (4%) 2 (4%)
Urinary Bladder (50) (50) (48) (50)
Necrosis 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------