TDMS Study 05156-05 Pathology Tables
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:18
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 10026-24-1
Lock Date: 07/15/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 19 20 20 17
Natural Death 3 4 4 3
Survivors
Terminal Sacrifice 28 25 26 30
Other 1
Animals Examined Microscopically 50 49 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (45) (48) (48)
Intestine Large, Cecum (48) (45) (47) (47)
Intestine Small, Duodenum (49) (46) (48) (48)
Intestine Small, Ileum (49) (45) (47) (47)
Liver (50) (49) (50) (49)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Mesentery (5) (8) (6) (13)
Sarcoma Stromal, Metastatic, Uterus 1 (13%)
Oral Mucosa (1) (2)
Pharyngeal, Squamous Cell Papilloma 1 (100%) 2 (100%)
Pancreas (49) (49) (50) (48)
Salivary Glands (50) (49) (50) (50)
Adenoma 1 (2%)
Sarcoma, Metastatic, Eye 1 (2%)
Stomach, Forestomach (50) (49) (50) (50)
Leiomyoma 1 (2%)
Stomach, Glandular (49) (49) (49) (48)
Carcinoid Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (50) (50)
Carcinoma, Metastatic, Lung 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Schwannoma Benign 1 (2%) 2 (4%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (49) (50) (49)
Adenoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Adrenal Medulla (48) (49) (50) (48)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 2 (4%) 1 (2%) 3 (6%) 7 (15%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (49) (49) (50) (48)
Adenoma 4 (8%) 1 (2%)
Carcinoma 2 (4%) 1 (2%)
Pituitary Gland (50) (49) (50) (49)
Pars Distalis, Adenoma 40 (80%) 39 (80%) 38 (76%) 40 (82%)
Thyroid Gland (49) (49) (50) (48)
C-Cell, Adenoma 6 (12%) 6 (12%) 7 (14%) 3 (6%)
C-Cell, Carcinoma 3 (6%) 2 (4%) 3 (6%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (48) (48) (49)
Adenoma 5 (10%) 7 (15%) 3 (6%) 3 (6%)
Carcinoma 2 (4%) 3 (6%) 4 (8%) 3 (6%)
Bilateral, Adenoma 2 (4%)
Ovary (50) (49) (50) (49)
Granulosa Cell Tumor Benign 1 (2%)
Bilateral, Granulosa-Theca Tumor Benign 1 (2%)
Uterus (50) (49) (50) (49)
Histiocytic Sarcoma 1 (2%)
Leiomyoma 1 (2%)
Polyp Stromal 8 (16%) 7 (14%) 10 (20%) 4 (8%)
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (50) (50)
Lymph Node (2) (3) (3) (2)
Lymph Node, Bronchial (30) (30) (37) (37)
Lymph Node, Mandibular (44) (40) (47) (45)
Sarcoma, Metastatic, Eye 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Lymph Node, Mesenteric (49) (49) (50) (48)
Lymph Node, Mediastinal (43) (38) (43) (45)
Spleen (49) (48) (50) (49)
Histiocytic Sarcoma 1 (2%)
Thymus (42) (45) (45) (44)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (50) (49)
Adenoma 2 (4%)
Carcinoma 2 (4%) 2 (4%) 5 (10%) 4 (8%)
Carcinoma, Multiple 1 (2%) 1 (2%)
Fibroadenoma 18 (36%) 18 (37%) 13 (26%) 20 (41%)
Fibroadenoma, Multiple 4 (8%) 4 (8%) 7 (14%) 7 (14%)
Skin (50) (49) (50) (50)
Basal Cell Adenoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 2 (4%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (50) (50)
Sarcoma, Metastatic, Eye 1 (2%)
Skeletal Muscle (1) (1)
Carcinoma, Metastatic, Lung 1 (100%)
Rhabdomyosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Astrocytoma Benign 1 (2%)
Astrocytoma Malignant 1 (2%)
Oligodendroglioma Benign 1 (2%)
Page 4
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 9 (18%) 7 (14%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 6 (12%) 6 (12%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Sarcoma, Metastatic, Eye 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Nose (50) (49) (50) (50)
Pleura (1)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (5) (3) (3)
Sarcoma 1 (33%)
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (49) (50) (48)
Histiocytic Sarcoma 1 (2%)
Lipoma 1 (2%) 1 (2%)
Mesenchymal Tumor Benign 1 (2%)
Bilateral, Renal Tubule, Carcinoma, Multiple 1 (2%)
Urinary Bladder (49) (49) (50) (47)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(49) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leukemia Mononuclear 15 (30%) 16 (33%) 19 (38%) 10 (20%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 47 50 46
Total Primary Neoplasms 123 122 141 139
Total Animals with Benign Neoplasms 45 44 47 44
Total Benign Neoplasms 96 94 97 105
Total Animals with Malignant Neoplasms 25 23 32 27
Total Malignant Neoplasms 27 28 44 34
Total Animals with Metastatic Neoplasms 3 3 1 3
Total Metastatic Neoplasm 3 3 2 9
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 30 34 26 34
Natural Death 3 1 3 1
Survivors
Terminal Sacrifice 17 15 21 15
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (50) (49) (49)
Intestine Large, Cecum (48) (49) (48) (49)
Intestine Small, Duodenum (50) (50) (48) (49)
Intestine Small, Jejunum (49) (49) (47) (49)
Intestine Small, Ileum (50) (49) (47) (48)
Liver (50) (50) (48) (50)
Carcinoma, Metastatic, Seminal Vesicle 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%) 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Mesentery (21) (14) (11) (14)
Carcinoma, Metastatic, Seminal Vesicle 1 (7%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (7%)
Fat, Lipoma 1 (9%)
Pancreas (50) (50) (48) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Carcinoma, Metastatic, Seminal Vesicle 1 (2%)
Mixed Tumor Malignant 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (49) (50)
Stomach, Glandular (50) (50) (48) (50)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Carcinoma, Metastatic, Seminal Vesicle 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (48) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%) 1 (2%)
Adrenal Medulla (50) (50) (49) (50)
Pheochromocytoma Malignant 2 (4%) 2 (4%) 2 (4%)
Pheochromocytoma Complex 1 (2%) 1 (2%)
Pheochromocytoma Benign 13 (26%) 15 (30%) 17 (35%) 15 (30%)
Bilateral, Pheochromocytoma Benign 1 (2%) 4 (8%) 6 (12%) 5 (10%)
Islets, Pancreatic (50) (50) (48) (50)
Adenoma 1 (2%) 4 (8%) 5 (10%) 5 (10%)
Adenoma, Multiple 1 (2%) 1 (2%)
Carcinoma 3 (6%) 4 (8%) 4 (8%) 7 (14%)
Pituitary Gland (49) (49) (50) (49)
Pars Distalis, Adenoma 43 (88%) 40 (82%) 42 (84%) 41 (84%)
Thyroid Gland (49) (50) (48) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 4 (8%) 2 (4%) 3 (6%) 3 (6%)
C-Cell, Carcinoma 3 (6%) 3 (6%) 4 (8%) 3 (6%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2) (1) (1)
Sarcoma, Metastatic, Uncertain Primary Site 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (50) (50) (49) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 2 (4%) 2 (4%) 3 (6%)
Bilateral, Adenoma 1 (2%)
Bilateral, Carcinoma 1 (2%)
Prostate (50) (50) (49) (50)
Adenoma 1 (2%) 2 (4%) 4 (8%) 1 (2%)
Seminal Vesicle (50) (50) (49) (49)
Carcinoma 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 26 (52%) 18 (36%) 26 (52%) 19 (38%)
Interstitial Cell, Adenoma 9 (18%) 13 (26%) 7 (14%) 10 (20%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (48) (50)
Lymph Node (8) (9) (9) (9)
Lymph Node, Bronchial (45) (30) (41) (49)
Lymph Node, Mandibular (46) (47) (47) (49)
Lymph Node, Mesenteric (50) (50) (48) (50)
Lymph Node, Mediastinal (47) (46) (44) (49)
Carcinoma, Metastatic, Seminal Vesicle 1 (2%)
Spleen (50) (50) (49) (50)
Carcinoma, Metastatic, Seminal Vesicle 1 (2%)
Fibroma 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Thymus (45) (42) (47) (48)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (30) (34) (36) (38)
Fibroadenoma 3 (10%) 1 (3%) 2 (6%) 3 (8%)
Fibroadenoma, Multiple 1 (3%)
Skin (50) (48) (50) (50)
Basal Cell Adenoma 2 (4%)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 2 (4%) 5 (10%) 2 (4%)
Keratoacanthoma, Multiple 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Squamous Cell Papilloma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 2 (4%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%) 2 (4%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Chordoma 1 (2%) 1 (2%)
Osteosarcoma 3 (6%)
Skeletal Muscle (2) (1) (1)
Carcinoma, Metastatic, Seminal Vesicle 1 (50%)
Sarcoma 1 (100%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (50%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%) 1 (2%)
Spinal Cord (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (48) (50)
Lung (50) (50) (48) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 4 (8%) 1 (2%) 5 (10%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 1 (2%)
Carcinoma, Metastatic, Seminal Vesicle 1 (2%)
Chordoma, Metastatic, Bone 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Nose (50) (50) (49) (50)
Nasopharyngeal Duct, Squamous Cell Carcinoma 1 (2%)
Pleura (1)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (2)
Carcinoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (48) (50)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Urinary Bladder (50) (50) (48) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 30 (60%) 32 (64%) 29 (58%) 28 (56%)
Mesothelioma Malignant 3 (6%) 2 (4%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05156-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COBALT SULFATE HEPTAHYDRATE Date: 07/25/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:24:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.3 1.0 3.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50 50
Total Primary Neoplasms 159 169 173 178
Total Animals with Benign Neoplasms 48 46 47 48
Total Benign Neoplasms 111 113 124 122
Total Animals with Malignant Neoplasms 38 41 35 38
Total Malignant Neoplasms 48 56 49 56
Total Animals with Metastatic Neoplasms 1 3 1
Total Metastatic Neoplasm 1 18 1
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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