TDMS Study 05156-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest COBALT SULFATE HEPTAHYDRATE DATE: 07/25/96
EXPERIMENT: 05156 TEST: 05 TIME: 11:39:04
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-05287 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61530B
PATHOLOGIST: GRUMBEIN, S. CAS: 10026-24-1
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest COBALT SULFATE HEPTAHYDRATE DATE: 07/25/96
EXPERIMENT: 05156 TEST: 05 TIME: 11:39:04
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05287 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61530B
PATHOLOGIST: GRUMBEIN, S. CAS: 10026-24-1
COBALT SULFATE HEPTAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 435 453 526 526 527 534 548 568 576 579 |
| 582 589 593 602 602 603 605 610 610 610 |
| 619 631 632 643 645 649 664 673 679 680 |
| 691 692 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.3 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 35 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 408 471 475 495 541 554 576 579 589 589 |
| 600 610 629 629 631 631 632 638 638 645 |
| 646 649 652 663 669 671 678 680 680 681 |
| 691 694 701 719 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 272 435 467 509 518 526 534 581 582 611 |
| 611 630 631 632 642 649 652 654 657 671 |
| 673 673 678 681 694 699 709 713 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
COBALT SULFATE HEPTAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 3.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 35 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 401 463 463 511 526 534 545 562 562 567 |
| 574 579 586 589 593 603 604 611 611 611 |
| 632 638 638 643 646 663 666 669 673 680 |
| 692 693 694 706 720 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
COBALT SULFATE HEPTAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 96.0 88.0 66.0 46.0 34.0 |
| | |
| | |
|0.3 | 100.0 100.0 100.0 100.0 98.0 94.0 90.0 78.0 52.0 30.0 |
|MG/M3 | |
| | |
|1.0 | 100.0 100.0 100.0 98.0 98.0 94.0 86.0 82.0 62.0 42.0 |
|MG/M3 | |
| | |
|3.0 | 100.0 100.0 100.0 100.0 98.0 94.0 86.0 66.0 48.0 30.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.3 1.0 3.0 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 34.0% 30.0% 42.0% 30.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.723 P=1.000N P=0.292N P=0.876 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 603.1 621.6 610.8 604.2 |
|NATURAL DEATHS (C) | (11.4) (12.4) (18.5) (12.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 647.6 655.3 662.5 643.2 |
|(STANDARD ERROR) | (11.6) (11.4) (13.8) (12.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
COBALT SULFATE HEPTAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 385 569 572 582 582 602 610 632 638 666 |
| 679 692 694 705 709 709 719 721 727 727 |
| 733 733 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.3 MG/M3 |
| ---------------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 362 420 483 491 517 526 526 585 610 610 |
| 610 652 670 673 673 687 694 702 709 709 |
| 714 722 728 731 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 355 510 526 541 568 596 600 603 619 632 |
| 652 659 685 692 694 695 709 722 722 722 |
| 723 727 729 732 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
COBALT SULFATE HEPTAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 3.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 6 386 470 585 610 611 632 642 650 652 |
| 663 673 679 680 686 692 693 709 709 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
COBALT SULFATE HEPTAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.0 98.0 98.0 88.0 82.0 56.0 |
| | |
| | |
|0.3 | 100.0 100.0 100.0 98.0 95.9 93.9 85.7 83.7 75.5 51.0 |
|MG/M3 | |
| | |
|1.0 | 100.0 100.0 100.0 98.0 98.0 98.0 92.0 84.0 76.0 52.0 |
|MG/M3 | |
| | |
|3.0 | 98.0 98.0 98.0 98.0 96.0 94.0 94.0 92.0 78.0 60.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.3 1.0 3.0 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.0% 51.0% 52.0% 60.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.642N P=0.583 P=0.756 P=0.959N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 653.9 616.8 642.2 607.5 |
|NATURAL DEATHS (C) | (17.8) (21.6) (19.0) (36.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 699.3 677.1 690.5 684.0 |
|(STANDARD ERROR) | ( 9.6) (13.5) (11.2) (16.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
COBALT SULFATE HEPTAHYDRATE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.3 MG/M3 = 2
1.0 MG/M3 = 3
3.0 MG/M3 = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
104 +
|
| 1 3 42 1
| 3 42 1 1 42
96 + 3 1 3 1
| 32 2 3
| 2 33 4 2
| 3 112 2
88 + 31412 2
| 341 413
| 113 2
| 3 3
P 80 + 4411 22
E | 441 12 2 3
R | 44 2 23
C | 4 11
E 72 + 223
N | 411 33
T | 33
| 11 22
S 64 +
U | 223 3
R | 11 4 33
V | 1 14
I 56 + 22
V | 11 2 2 33
A | 11 22 3 3
L | 4 4
48 + 1 122 3 3
| 1 12
| 44 3 3
| 11 3
40 + 11
| 22
| 122 1
| 42 21 1
32 + 4 22
| 42 2
|
|
24 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 39 obs hidden.
COBALT SULFATE HEPTAHYDRATE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.3 MG/M3 = 2
1.0 MG/M3 = 3
3.0 MG/M3 = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 14 32 1
|
| 4 32 14 2 3 1
| 4 2 42 3 3
95 +
| 42 2 3 3 1 1
| 3 3 4 4
| 2 2
90 + 2 2 3 1 1
|
| 1 1 4
| 2 2 331 14
P 85 +
E | 2 323 114
R | 3 3144 1
C |
E 80 + 3 3 411
N |
T | 2 2 3 1 1
| 3 311
S 75 + 2 2
U | 223311
R | 3311
V |
I 70 + 242
V |
A | 22 11
L | 4 3 3
65 + 22
| 2211
| 4 4
|
60 + 1 1
|
| 2 2
| 3 1
55 +
|
| 2 2
| 2
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 22 obs hidden.