TDMS Study 05158-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest MOLYBDENUM TRIOXIDE DATE: 04/04/96
EXPERIMENT: 05158 TEST: 04 TIME: 02:49:15
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-95240 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61369C
PATHOLOGIST: R. MILLER CAS: 1313-27-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest MOLYBDENUM TRIOXIDE DATE: 04/04/96
EXPERIMENT: 05158 TEST: 04 TIME: 02:49:15
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95240 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61369C
PATHOLOGIST: R. MILLER CAS: 1313-27-5
MOLYBDENUM TRIOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 350 433 435 473 544 580 592 629 636 651 |
| 651 656 698 712 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 448 549 580 587 653 653 655 664 689 692 |
| 692 699 705 708 709 720 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 365 440 442 451 451 513 513 513 516 538 |
| 551 553 631 638 667 669 679 685 692 705 |
| 709 713 715 729 730 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MOLYBDENUM TRIOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 328 408 576 580 592 629 636 670 677 686 |
| 690 715 720 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MOLYBDENUM TRIOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 98.0 92.0 90.0 86.0 76.0 72.0 |
| | |
| | |
|10 MG/M3 | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 92.0 84.0 66.0 |
| | |
| | |
|30 MG/M3 | 100.0 100.0 100.0 98.0 98.0 90.0 80.0 76.0 72.0 50.0 |
| | |
| | |
|100 | 100.0 100.0 100.0 98.0 96.0 96.0 96.0 90.0 86.0 74.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 10 MG/M3 30 MG/M3 100 |
| MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 72.0% 66.0% 50.0% 74.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.536N P=0.843 P=0.052 P=0.908N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 574.3 654.5 592.3 608.2 |
|NATURAL DEATHS (C) | (29.7) (17.9) (22.5) (32.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 688.6 706.3 662.7 700.6 |
|(STANDARD ERROR) | (13.0) ( 8.0) (15.0) (11.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MOLYBDENUM TRIOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 469 511 548 552 552 562 581 587 590 594 |
| 626 634 636 642 670 674 692 692 692 705 |
| 709 720 720 729 730 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 1 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 220 456 531 592 594 600 610 619 629 636 |
| 639 670 681 692 709 709 723 730 |
| CENSORED DEATHS |
| 692 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 1 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 288 562 603 638 653 670 678 689 692 705 |
| 705 709 712 712 720 723 |
| CENSORED DEATHS |
| 566 |
| |
==================================================================================
MOLYBDENUM TRIOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 165 302 350 498 531 534 620 632 650 664 |
| 667 671 698 699 715 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MOLYBDENUM TRIOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 80.0 72.0 50.0 |
| | |
| | |
|10 MG/M3 | 100.0 100.0 98.0 98.0 98.0 96.0 94.0 88.0 78.0 63.8 |
| | |
| | |
|30 MG/M3 | 100.0 100.0 100.0 98.0 98.0 98.0 98.0 94.0 89.9 67.4 |
| | |
| | |
|100 | 100.0 98.0 98.0 94.0 94.0 94.0 88.0 88.0 80.0 70.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 10 MG/M3 30 MG/M3 100 |
| MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 50.0% 63.8% 67.4% 70.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.174N P=0.230N P=0.074N P=0.096N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 632.7 613.3 653.7 559.7 |
|NATURAL DEATHS (C) | (14.9) (28.4) (26.8) (42.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 682.8 689.1 704.3 681.0 |
|(STANDARD ERROR) | (10.3) (12.9) (10.3) (16.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MOLYBDENUM TRIOXIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
10 MG/M3 = 2
30 MG/M3 = 3
100 MG/M3 = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 4 1 3 2
|
| 4 1 3 4 132 2
| 4 113 2 2
95 +
| 13 3 1 22
| 1 1 42 4 2
|
90 + 3 3 1 1 4 4
|
| 1 1 44
| 1 14 2 24
P 85 +
E | 11 244 2
R | 3 3 1 1 44
C |
E 80 + 3 3 44
N |
T | 11 22 4
| 3 3 1 12
S 75 +
U | 33 1214 4
R | 3 3 1 1
V |
I 70 + 22
V |
A | 33 22
L | 33 2 2
65 +
| 33
| 3 3
|
60 + 33
|
|
| 33
55 +
| 3 3
|
|
50 + 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
MOLYBDENUM TRIOXIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
10 MG/M3 = 2
30 MG/M3 = 3
100 MG/M3 = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 4 2 3 1
|
| 4 2 3 4 21 1 3
| 4 4 2 1 2 1 3 3
95 +
| 4 4 2 2 3 3
| 4 4 3 3
|
90 + 44 1 1 22 3 3
|
| 4 1 1 2 24 33
| 11 22 4 3 3
P 85 +
E | 1 1 224 4
R | 22 4 4
C | 3 3
E 80 + 1 122 44
N |
T | 112 2 33
| 2 2 4
S 75 +
U | 11 22
R | 1 1 24 24
V | 33
I 70 + 11 33 4
V |
A | 1 1 2 2 3
L | 2 2
65 +
| 2
| 1 1
|
60 + 11
|
| 11
|
55 +
| 1 1
|
|
50 + 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.