TDMS Study 05158-03 Pathology Tables
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:06
Facility: Battelle Northwest
Chemical CAS #: 0001313-27-5
Lock Date: 08/06/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 18 25 23 23
Natural Death 4 1 3 4
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 28 24 24 22
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (49) (48) (48)
Necrosis 1 (2%)
Intestine Large, Rectum (49) (50) (46) (50)
Mineralization 1 (2%)
Intestine Large, Cecum (49) (49) (47) (48)
Mineralization 1 (2%) 3 (6%)
Intestine Small, Duodenum (49) (49) (48) (49)
Inflammation, Acute 1 (2%)
Intestine Small, Ileum (48) (49) (47) (48)
Inflammation, Chronic Active 1 (2%)
Liver (50) (49) (50) (50)
Angiectasis 3 (6%) 1 (2%) 4 (8%) 3 (6%)
Basophilic Focus 43 (86%) 44 (90%) 43 (86%) 39 (78%)
Clear Cell Focus 7 (14%) 5 (10%) 11 (22%) 7 (14%)
Degeneration, Cystic 1 (2%)
Degeneration, Fatty 18 (36%) 18 (37%) 13 (26%) 18 (36%)
Eosinophilic Focus 5 (10%) 1 (2%) 2 (4%) 4 (8%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%)
Hepatodiaphragmatic Nodule 5 (10%) 10 (20%) 9 (18%) 9 (18%)
Mixed Cell Focus 9 (18%) 9 (18%) 6 (12%) 12 (24%)
Necrosis 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic, Focal 3 (6%) 2 (4%) 4 (8%)
Bile Duct, Hyperplasia 15 (30%) 11 (22%) 12 (24%) 10 (20%)
Centrilobular, Necrosis 5 (10%) 7 (14%) 2 (4%) 4 (8%)
Mesentery (3) (11) (5) (8)
Artery, Inflammation, Chronic Active 1 (20%)
Fat, Necrosis 2 (67%) 11 (100%) 4 (80%) 8 (100%)
Pancreas (49) (49) (50) (50)
Atrophy 21 (43%) 11 (22%) 15 (30%) 18 (36%)
Basophilic Focus 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 3 (6%)
Artery, Inflammation 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%) 2 (4%)
Stomach, Forestomach (50) (49) (50) (50)
Hyperplasia, Squamous 2 (4%) 1 (2%) 2 (4%)
Mineralization 1 (2%) 1 (2%) 1 (2%) 5 (10%)
Necrosis 3 (6%) 5 (10%) 2 (4%) 8 (16%)
Stomach, Glandular (49) (49) (50) (50)
Inflammation, Chronic Active 1 (2%)
Mineralization 7 (14%) 11 (22%) 8 (16%) 6 (12%)
Necrosis 2 (4%) 3 (6%) 1 (2%)
Tooth (1)
Developmental Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 41 (82%) 41 (82%) 43 (86%) 46 (92%)
Artery, Thrombosis 1 (2%)
Atrium, Thrombosis 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (49) (50) (50)
Degeneration, Cystic 2 (4%) 2 (4%) 1 (2%)
Hyperplasia 21 (43%) 23 (47%) 26 (52%) 25 (50%)
Hypertrophy 9 (18%) 10 (20%) 8 (16%) 8 (16%)
Necrosis 1 (2%) 3 (6%) 1 (2%)
Vacuolization Cytoplasmic 6 (12%) 6 (12%) 4 (8%) 4 (8%)
Adrenal Medulla (49) (49) (50) (50)
Hyperplasia 9 (18%) 12 (24%) 12 (24%) 7 (14%)
Islets, Pancreatic (49) (49) (50) (50)
Hyperplasia 2 (4%)
Parathyroid Gland (50) (49) (48) (48)
Hyperplasia 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Pituitary Gland (49) (50) (50) (50)
Pars Distalis, Cyst 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 3 (6%) 9 (18%) 9 (18%) 8 (16%)
Thyroid Gland (49) (49) (50) (50)
Bilateral, C-Cell, Hyperplasia 1 (2%)
C-Cell, Hyperplasia 41 (84%) 37 (76%) 42 (84%) 41 (82%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (44) (48) (47) (47)
Cyst 1 (2%)
Hyperplasia 2 (4%) 1 (2%)
Inflammation, Chronic Active 2 (5%) 6 (13%) 4 (9%) 3 (6%)
Duct, Hyperplasia, Squamous 2 (4%)
Ovary (50) (50) (50) (50)
Cyst 3 (6%) 6 (12%) 7 (14%) 7 (14%)
Hyperplasia, Tubular 1 (2%)
Uterus (50) (49) (50) (50)
Hydrometra 2 (4%)
Endometrium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (3) (8) (2) (2)
Pancreatic, Hemorrhage 1 (50%)
Pancreatic, Pigmentation 1 (13%)
Renal, Ectasia 1 (50%)
Renal, Hemorrhage 1 (13%)
Lymph Node, Mandibular (46) (41) (47) (43)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%)
Lymph Node, Mediastinal (41) (41) (43) (48)
Hemorrhage 1 (2%)
Spleen (49) (49) (50) (50)
Accessory Spleen 1 (2%)
Fibrosis 3 (6%) 5 (10%) 2 (4%)
Hematopoietic Cell Proliferation 4 (8%) 2 (4%) 6 (12%) 2 (4%)
Hemorrhage 1 (2%) 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50)
Galactocele 1 (2%)
Hyperplasia, Atypical 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Skin (50) (49) (50) (50)
Hyperkeratosis 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Subcutaneous Tissue, Angiectasis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 1 (2%)
Hyperostosis 4 (8%) 4 (8%) 1 (2%) 9 (18%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Thrombosis 1 (2%)
Meninges, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (49) (49) (50)
Epiglottis, Hyperplasia 3 (6%) 10 (20%) 5 (10%) 1 (2%)
Epiglottis, Metaplasia, Squamous 18 (37%) 29 (59%) 49 (98%)
Lung (50) (50) (50) (50)
Metaplasia, Focal 1 (2%)
Metaplasia, Squamous 1 (2%)
Alveolar Epithelium, Hyperplasia 7 (14%) 10 (20%) 12 (24%) 7 (14%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%)
Alveolus, Inflammation, Chronic 14 (28%) 13 (26%) 43 (86%) 49 (98%)
Bronchiole, Hyperplasia 1 (2%)
Mediastinum, Thrombosis 1 (2%)
Nose (48) (49) (50) (50)
Inflammation, Suppurative 7 (15%) 2 (4%) 6 (12%) 2 (4%)
Thrombosis 4 (8%) 5 (10%) 1 (2%) 4 (8%)
Olfactory Epithelium, Degeneration, Hyaline 39 (81%) 47 (96%) 50 (100%) 50 (100%)
Olfactory Epithelium, Metaplasia, Focal 1 (2%)
Respiratory Epithelium, Degeneration, Hyaline 1 (2%) 13 (27%) 50 (100%) 50 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (6) (1) (2)
Cataract 1 (17%) 1 (100%)
Degeneration 1 (100%) 4 (67%) 2 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50) (50)
Cyst 1 (2%) 1 (2%)
Infarct 1 (2%)
Nephropathy 48 (96%) 47 (96%) 47 (94%) 50 (100%)
Renal Tubule, Hyperplasia 1 (2%) 3 (6%) 2 (4%) 1 (2%)
Transitional Epithelium, Mineralization 1 (2%)
Urinary Bladder (49) (50) (50) (50)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 4 5 3 5
Moribund Sacrifice 29 35 31 28
Survivors
Terminal Sacrifice 16 10 16 17
Moribund Sacrifice 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (46) (50) (50)
Mineralization 1 (2%)
Intestine Large, Cecum (48) (47) (48) (49)
Hemorrhage 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Necrosis 1 (2%)
Intestine Small, Duodenum (49) (48) (49) (49)
Mineralization 1 (2%)
Necrosis 2 (4%)
Intestine Small, Ileum (48) (47) (46) (49)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 3 (6%) 6 (12%) 1 (2%) 2 (4%)
Basophilic Focus 21 (42%) 21 (42%) 23 (46%) 21 (42%)
Clear Cell Focus 5 (10%) 4 (8%) 7 (14%) 3 (6%)
Cyst 1 (2%)
Degeneration, Cystic 17 (34%) 16 (32%) 16 (32%) 24 (48%)
Degeneration, Fatty 15 (30%) 15 (30%) 17 (34%) 14 (28%)
Eosinophilic Focus 4 (8%) 8 (16%) 7 (14%) 10 (20%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%) 5 (10%) 4 (8%)
Mixed Cell Focus 5 (10%) 3 (6%) 3 (6%) 5 (10%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic, Focal 2 (4%) 1 (2%)
Bile Duct, Hyperplasia 46 (92%) 35 (70%) 40 (80%) 39 (78%)
Centrilobular, Necrosis 14 (28%) 11 (22%) 12 (24%) 10 (20%)
Mesentery (10) (9) (9) (11)
Inflammation, Acute 1 (11%)
Artery, Mineralization 1 (11%)
Fat, Hemorrhage 1 (11%)
Fat, Necrosis 9 (90%) 6 (67%) 9 (100%) 10 (91%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (50) (50) (50) (50)
Atrophy 32 (64%) 28 (56%) 24 (48%) 34 (68%)
Basophilic Focus 1 (2%) 2 (4%)
Hyperplasia 6 (12%) 2 (4%) 2 (4%) 5 (10%)
Thrombosis 1 (2%)
Artery, Inflammation 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 2 (4%) 3 (6%)
Artery, Mineralization 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Hyperplasia, Squamous 2 (4%) 2 (4%)
Inflammation, Acute 1 (2%)
Mineralization 3 (6%) 4 (8%) 4 (8%) 1 (2%)
Necrosis 11 (22%) 4 (8%) 7 (14%) 4 (8%)
Stomach, Glandular (50) (50) (50) (50)
Mineralization 5 (10%) 7 (14%) 5 (10%) 10 (20%)
Necrosis 7 (14%) 6 (12%) 4 (8%) 2 (4%)
Tooth (2) (1)
Developmental Malformation 1 (50%)
Inflammation, Chronic Active 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (2) (1) (2)
Aorta, Mineralization 1 (100%) 2 (100%) 1 (100%) 2 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 44 (88%) 38 (76%) 40 (80%) 45 (90%)
Artery, Mineralization 1 (2%) 2 (4%) 1 (2%) 3 (6%)
Atrium, Thrombosis 5 (10%) 7 (14%) 6 (12%) 4 (8%)
Endocardium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Hyperplasia 35 (70%) 19 (38%) 26 (52%) 26 (52%)
Hypertrophy 5 (10%) 6 (12%) 8 (16%) 8 (16%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 4 (8%) 2 (4%) 2 (4%) 2 (4%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 31 (62%) 25 (50%) 27 (54%) 25 (50%)
Bilateral, Hyperplasia 1 (2%) 2 (4%) 1 (2%) 4 (8%)
Islets, Pancreatic (50) (50) (49) (49)
Hyperplasia 3 (6%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Parathyroid Gland (47) (49) (46) (49)
Hyperplasia 11 (23%) 9 (18%) 10 (22%) 14 (29%)
Pituitary Gland (49) (50) (50) (48)
Pars Distalis, Hyperplasia 7 (14%) 7 (14%) 6 (12%) 6 (13%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 35 (70%) 29 (58%) 31 (62%) 30 (60%)
Follicular Cell, Hyperplasia 2 (4%) 4 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%) 1 (2%) 1 (2%)
Penis (2)
Inflammation, Acute 1 (50%)
Preputial Gland (50) (50) (50) (50)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 1 (2%) 4 (8%) 3 (6%) 3 (6%)
Prostate (50) (50) (50) (50)
Hyperplasia 6 (12%) 6 (12%) 12 (24%) 7 (14%)
Inflammation, Chronic Active 4 (8%) 5 (10%) 2 (4%) 5 (10%)
Seminal Vesicle (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 6 (12%) 4 (8%) 3 (6%) 2 (4%)
Artery, Inflammation, Chronic Active 2 (4%) 4 (8%) 2 (4%) 2 (4%)
Interstitial Cell, Hyperplasia 7 (14%) 7 (14%) 7 (14%) 5 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Atrophy 1 (2%)
Myelofibrosis 1 (2%)
Necrosis 1 (2%)
Lymph Node (16) (17) (8) (15)
Iliac, Ectasia 1 (6%)
Iliac, Infiltration Cellular, Plasma Cell 1 (7%)
Renal, Hemorrhage 3 (19%) 1 (6%) 1 (13%)
Renal, Infiltration Cellular, Plasma Cell 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mandibular (48) (48) (49) (48)
Infiltration Cellular, Plasma Cell 1 (2%) 3 (6%) 1 (2%) 2 (4%)
Lymph Node, Mesenteric (50) (50) (50) (49)
Ectasia 2 (4%)
Lymph Node, Mediastinal (48) (49) (46) (48)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Spleen (50) (50) (50) (50)
Accessory Spleen 1 (2%) 1 (2%)
Atrophy 2 (4%)
Fibrosis 15 (30%) 13 (26%) 15 (30%) 17 (34%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 2 (4%) 1 (2%)
Necrosis 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Thrombosis 1 (2%)
Thymus (45) (45) (44) (44)
Atrophy 1 (2%)
Cyst 1 (2%)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (30) (25) (25) (27)
Galactocele 3 (10%) 3 (12%) 1 (4%) 2 (7%)
Skin (49) (50) (49) (49)
Fibrosis 1 (2%)
Hyperkeratosis 3 (6%) 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic Active 3 (6%) 8 (16%) 3 (6%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 2 (4%) 1 (2%) 2 (4%) 5 (10%)
Hyperostosis 1 (2%) 1 (2%) 2 (4%)
Skeletal Muscle (2)
Mineralization 2 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Necrosis 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (48) (49) (49)
Hyperplasia 2 (4%) 1 (2%)
Inflammation, Chronic 1 (2%)
Metaplasia, Squamous 1 (2%)
Mineralization 1 (2%)
Epiglottis, Hyperplasia 8 (16%) 5 (10%) 13 (27%) 5 (10%)
Epiglottis, Inflammation, Chronic 1 (2%)
Epiglottis, Metaplasia, Squamous 11 (23%) 16 (33%) 39 (80%)
Lung (50) (50) (50) (50)
Foreign Body 1 (2%)
Hemorrhage 3 (6%) 3 (6%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Mineralization 1 (2%) 2 (4%) 2 (4%)
Thrombosis 2 (4%) 4 (8%) 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 7 (14%) 9 (18%) 12 (24%) 7 (14%)
Alveolar Epithelium, Inflammation, Chronic 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%)
Alveolus, Inflammation, Chronic 2 (4%) 3 (6%) 25 (50%) 47 (94%)
Artery, Mediastinum, Inflammation 1 (2%)
Artery, Mediastinum, Mineralization 1 (2%) 2 (4%) 2 (4%)
Interstitium, Fibrosis 1 (2%)
Nose (50) (49) (49) (50)
Inflammation, Suppurative 7 (14%) 5 (10%) 5 (10%) 3 (6%)
Thrombosis 14 (28%) 11 (22%) 15 (31%) 9 (18%)
Olfactory Epithelium, Degeneration, Hyaline 46 (92%) 43 (88%) 48 (98%) 49 (98%)
Olfactory Epithelium, Metaplasia, Focal 1 (2%)
Respiratory Epithelium, Degeneration, Hyaline 2 (4%) 7 (14%) 48 (98%) 49 (98%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Trachea (50) (50) (50) (50)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (1)
Cataract 1 (50%)
Degeneration 1 (50%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 1 (2%)
Cyst 3 (6%) 1 (2%)
Fibrosis, Focal 1 (2%)
Hyperplasia, Oncocytic 3 (6%)
Infarct 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Metaplasia 1 (2%)
Mineralization 2 (4%) 1 (2%) 3 (6%)
Nephropathy 50 (100%) 49 (98%) 49 (98%) 48 (96%)
Pelvis, Inflammation, Acute 1 (2%) 1 (2%)
Renal Tubule, Hyperplasia 6 (12%) 3 (6%) 7 (14%) 4 (8%)
Renal Tubule, Necrosis 2 (4%)
Transitional Epithelium, Hyperplasia 3 (6%) 3 (6%) 2 (4%) 4 (8%)
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
Mineralization 1 (2%)
Capillary, Hyperplasia 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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