TDMS Study 05158-03 Pathology Tables
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:07
Facility: Battelle Northwest
Chemical CAS #: 0001313-27-5
Lock Date: 08/06/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 18 25 23 23
Natural Death 4 1 3 4
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 28 24 24 22
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (49) (48) (48)
Sarcoma 1 (2%)
Intestine Large, Cecum (49) (49) (47) (48)
Intestine Small, Duodenum (49) (49) (48) (49)
Intestine Small, Jejunum (47) (49) (47) (47)
Intestine Small, Ileum (48) (49) (47) (48)
Liver (50) (49) (50) (50)
Hepatocellular Adenoma 1 (2%)
Mesentery (3) (11) (5) (8)
Oral Mucosa (1)
Gingival, Squamous Cell Carcinoma 1 (100%)
Pancreas (49) (49) (50) (50)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (49) (50) (50)
Stomach, Glandular (49) (49) (50) (50)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (49) (50) (50)
Adenoma 1 (2%)
Adrenal Medulla (49) (49) (50) (50)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 3 (6%) 4 (8%) 6 (12%)
Page 2
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Bilateral, Pheochromocytoma Benign 2 (4%)
Islets, Pancreatic (49) (49) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (49) (50) (50) (50)
Pars Distalis, Adenoma 43 (88%) 39 (78%) 40 (80%) 38 (76%)
Thyroid Gland (49) (49) (50) (50)
C-Cell, Adenoma 3 (6%) 8 (16%) 6 (12%) 3 (6%)
C-Cell, Carcinoma 3 (6%) 1 (2%) 1 (2%) 2 (4%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (44) (48) (47) (47)
Adenoma 2 (5%) 6 (13%) 5 (11%) 1 (2%)
Carcinoma 1 (2%) 1 (2%) 5 (11%) 2 (4%)
Ovary (50) (50) (50) (50)
Granulosa Cell Tumor Malignant 1 (2%) 1 (2%)
Granulosa-Theca Tumor Malignant 1 (2%)
Uterus (50) (49) (50) (50)
Deciduoma Benign 1 (2%)
Leiomyoma 1 (2%)
Polyp Stromal 6 (12%) 8 (16%) 6 (12%) 8 (16%)
Polyp Stromal, Multiple 2 (4%)
Sarcoma Stromal 1 (2%) 2 (4%)
Vagina (1)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (50)
Lymph Node (3) (8) (2) (2)
Lymph Node, Bronchial (44) (36) (37) (40)
Lymph Node, Mandibular (46) (41) (47) (43)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Lymph Node, Mesenteric (49) (49) (50) (50)
Lymph Node, Mediastinal (41) (41) (43) (48)
Spleen (49) (49) (50) (50)
Thymus (48) (45) (47) (46)
Page 3
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50)
Adenoma 3 (6%) 3 (6%) 1 (2%)
Carcinoma 1 (2%) 2 (4%) 2 (4%) 3 (6%)
Fibroadenoma 16 (32%) 24 (48%) 22 (45%) 13 (26%)
Fibroadenoma, Multiple 6 (12%) 8 (16%) 6 (12%) 5 (10%)
Skin (50) (49) (50) (50)
Basal Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Melanoma Malignant 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Benign 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Oligodendroglioma Benign 1 (2%)
Meninges, Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (49) (49) (50)
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%) 1 (2%)
Melanoma Malignant, Metastatic, Skin 1 (2%)
Sarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Nose (48) (49) (50) (50)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1) (2)
Carcinoma 1 (100%) 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50) (50)
Lipoma 1 (2%) 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%) 1 (2%)
Urinary Bladder (49) (50) (50) (50)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 18 (36%) 19 (38%) 13 (26%) 20 (40%)
Lymphoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 50 49 49
Total Primary Neoplasms 119 129 127 115
Total Animals with Benign Neoplasms 45 49 49 47
Total Benign Neoplasms 87 100 102 81
Total Animals with Malignant Neoplasms 28 23 23 30
Total Malignant Neoplasms 32 29 25 34
Total Animals with Metastatic Neoplasms 1 1 1
Total Metastatic Neoplasm 1 3 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 4 5 3 5
Moribund Sacrifice 29 35 31 28
Survivors
Terminal Sacrifice 16 10 16 17
Moribund Sacrifice 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (46) (50) (50)
Intestine Large, Rectum (49) (49) (50) (49)
Intestine Large, Cecum (48) (47) (48) (49)
Leiomyoma 1 (2%)
Intestine Small, Duodenum (49) (48) (49) (49)
Carcinoma 1 (2%) 1 (2%)
Intestine Small, Jejunum (48) (48) (48) (48)
Intestine Small, Ileum (48) (47) (46) (49)
Liver (50) (50) (50) (50)
Hepatocellular Carcinoma 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Mesentery (10) (9) (9) (11)
Oral Mucosa (1) (1) (1)
Pharyngeal, Squamous Cell Carcinoma 1 (100%)
Pharyngeal, Squamous Cell Papilloma 1 (100%) 1 (100%)
Pancreas (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Mixed Tumor Benign 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Stomach, Glandular (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Hemangioma 1 (2%)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 2 (4%)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 15 (30%) 4 (8%) 15 (30%) 14 (28%)
Bilateral, Pheochromocytoma Benign 7 (14%) 2 (4%) 3 (6%)
Islets, Pancreatic (50) (50) (49) (49)
Adenoma 3 (6%) 6 (12%) 1 (2%) 4 (8%)
Carcinoma 1 (2%) 2 (4%) 2 (4%) 4 (8%)
Parathyroid Gland (47) (49) (46) (49)
Adenoma 1 (2%)
Pituitary Gland (49) (50) (50) (48)
Pars Distalis, Adenoma 37 (76%) 39 (78%) 40 (80%) 36 (75%)
Thyroid Gland (50) (50) (50) (50)
Bilateral, C-Cell, Adenoma 2 (4%) 2 (4%)
C-Cell, Adenoma 3 (6%) 3 (6%) 6 (12%) 3 (6%)
C-Cell, Carcinoma 4 (8%) 1 (2%) 3 (6%)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Chemodectoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (50) (50) (50) (50)
Adenoma 2 (4%) 3 (6%) 3 (6%) 3 (6%)
Carcinoma 3 (6%) 3 (6%) 1 (2%) 1 (2%)
Prostate (50) (50) (50) (50)
Adenoma, Multiple 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 30 (60%) 21 (42%) 23 (46%) 30 (60%)
Interstitial Cell, Adenoma 9 (18%) 11 (22%) 13 (26%) 8 (16%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Lymph Node (16) (17) (8) (15)
Iliac, Squamous Cell Carcinoma, Metastatic,
Skin 1 (6%)
Lymph Node, Bronchial (45) (45) (42) (43)
Lymph Node, Mandibular (48) (48) (49) (48)
Lymph Node, Mesenteric (50) (50) (50) (49)
Lymph Node, Mediastinal (48) (49) (46) (48)
Spleen (50) (50) (50) (50)
Fibroma 2 (4%)
Hemangiosarcoma 1 (2%)
Sarcoma 1 (2%)
Thymus (45) (45) (44) (44)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (30) (25) (25) (27)
Fibroadenoma 2 (8%) 1 (4%)
Skin (49) (50) (49) (49)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 2 (4%)
Keratoacanthoma 1 (2%) 4 (8%) 1 (2%) 2 (4%)
Squamous Cell Carcinoma 1 (2%) 2 (4%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Sebaceous Gland, Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 3 (6%) 3 (6%) 3 (6%) 4 (8%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Meningioma Malignant 1 (2%)
Oligodendroglioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 3 (6%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Neoplasm NOS 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%) 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Nose (50) (49) (49) (50)
Carcinoma 1 (2%)
Chondroma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (2) (1)
Carcinoma 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Sarcoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 2 (4%) 2 (4%)
Urinary Bladder (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 35 (70%) 31 (62%) 28 (56%) 32 (64%)
Mesothelioma Benign 3 (6%) 3 (6%) 1 (2%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05158-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:54:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 10 MG/M3 30 MG/M3 100
MG/M3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50 49
Total Primary Neoplasms 165 162 166 176
Total Animals with Benign Neoplasms 50 48 49 46
Total Benign Neoplasms 112 112 122 124
Total Animals with Malignant Neoplasms 40 38 34 40
Total Malignant Neoplasms 53 49 44 52
Total Animals with Metastatic Neoplasms 1 1 1 2
Total Metastatic Neoplasm 2 1 1 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------