TDMS Study 05160-05 Pathology Tables
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
2 YEAR CHRONIC
Facility: TSI Mason Research
Chemical CAS #: 127-00-4
Lock Date: 05/25/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 12 7 7 5
Natural Death 13 10 13 14
Survivors
Terminal Sacrifice 25 33 30 31
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (47) (49) (49) (48)
Dilatation 1 (2%)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 3 (6%) 2 (4%) 2 (4%) 1 (2%)
Intestine Large, Rectum (49) (49) (48) (49)
Parasite Metazoan 6 (12%) 4 (8%) 3 (6%) 7 (14%)
Intestine Large, Cecum (47) (49) (48) (48)
Dilatation 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Parasite Metazoan 1 (2%)
Ulcer 1 (2%)
Intestine Small, Jejunum (44) (44) (43) (46)
Hemorrhage 1 (2%)
Intestine Small, Ileum (42) (45) (43) (45)
Hemorrhage 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 5 (10%) 3 (6%) 7 (14%)
Basophilic Focus 29 (58%) 33 (66%) 27 (54%) 32 (64%)
Clear Cell Focus 3 (6%) 7 (14%) 7 (14%) 2 (4%)
Congestion 2 (4%)
Deformity 3 (6%) 6 (12%) 3 (6%)
Eosinophilic Focus 6 (12%) 3 (6%) 7 (14%) 4 (8%)
Fibrosis 1 (2%)
Hemorrhage 2 (4%)
Hepatodiaphragmatic Nodule 2 (4%) 3 (6%) 12 (24%) 4 (8%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) 1 (2%)
Inflammation, Granulomatous 12 (24%) 5 (10%) 9 (18%) 11 (22%)
Mixed Cell Focus 4 (8%) 8 (16%) 5 (10%) 6 (12%)
Necrosis 3 (6%) 2 (4%) 5 (10%) 1 (2%)
Pigmentation, Bile 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 2 (4%) 3 (6%) 3 (6%)
Artery, Thrombosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Hyperplasia 1 (2%)
Centrilobular, Necrosis 1 (2%)
Kupffer Cell, Pigmentation 1 (2%)
Mesentery (9) (11) (12) (10)
Hemorrhage 1 (11%)
Fat, Necrosis 8 (89%) 10 (91%) 11 (92%) 9 (90%)
Pancreas (47) (49) (49) (48)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Acute 1 (2%)
Acinus, Atrophy 12 (26%) 4 (8%) 3 (6%) 5 (10%)
Acinus, Hyperplasia 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Inflammation, Chronic Active 5 (10%) 1 (2%) 3 (6%)
Ulcer 2 (4%) 2 (4%) 3 (6%) 4 (8%)
Epithelium, Hyperplasia 4 (8%) 3 (6%) 3 (6%) 3 (6%)
Stomach, Glandular (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Necrosis 12 (24%) 6 (12%) 7 (14%) 7 (14%)
Ulcer 2 (4%)
Tooth (1)
Developmental Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 18 (36%) 21 (42%) 15 (30%) 11 (22%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Atrium, Inflammation, Chronic Active 1 (2%)
Atrium, Thrombosis 4 (8%) 2 (4%) 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Angiectasis 7 (14%) 8 (16%) 9 (18%) 10 (20%)
Cytoplasmic Alteration 5 (10%) 3 (6%) 1 (2%) 4 (8%)
Degeneration, Cystic 1 (2%) 1 (2%)
Hemorrhage 2 (4%) 3 (6%)
Vacuolization Cytoplasmic 4 (8%) 5 (10%) 7 (14%) 8 (16%)
Adrenal Medulla (49) (50) (50) (50)
Hyperplasia 5 (10%) 1 (2%) 2 (4%)
Infiltration Cellular, Lymphocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Necrosis 1 (2%)
Islets, Pancreatic (46) (49) (48) (48)
Hyperplasia 1 (2%)
Metaplasia 1 (2%)
Parathyroid Gland (50) (50) (50) (49)
Angiectasis 1 (2%)
Hyperplasia 1 (2%)
Pituitary Gland (49) (50) (50) (50)
Necrosis 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 4 (8%) 1 (2%)
Pars Distalis, Cyst 13 (27%) 11 (22%) 11 (22%) 13 (26%)
Pars Distalis, Hemorrhage 2 (4%) 1 (2%)
Pars Distalis, Hyperplasia 4 (8%) 6 (12%) 6 (12%)
Pars Distalis, Pigmentation 1 (2%)
Pars Nervosa, Cyst 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Chronic Active 1 (2%)
C-Cell, Hyperplasia 10 (20%) 11 (22%) 6 (12%) 8 (16%)
Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (49) (49) (49)
Atrophy 2 (4%)
Cyst 4 (8%) 4 (8%) 4 (8%) 6 (12%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 3 (6%) 1 (2%)
Bilateral, Cyst 1 (2%)
Ovary (50) (50) (50) (50)
Angiectasis 1 (2%)
Cyst 6 (12%) 4 (8%) 10 (20%) 8 (16%)
Hyperplasia, Histiocytic 1 (2%)
Inflammation, Granulomatous 1 (2%)
Bilateral, Cyst 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Uterus (50) (50) (50) (50)
Abscess 1 (2%)
Cyst 1 (2%) 2 (4%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hydrometra 4 (8%) 3 (6%) 4 (8%)
Hyperplasia, Cystic 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 3 (6%)
Bilateral, Hydrometra 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Vagina (2)
Hemorrhage 1 (50%)
Infiltration Cellular, Polymorphonuclear 1 (50%)
Inflammation, Chronic Active 1 (50%)
Pigmentation 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (47) (50) (47) (49)
Atrophy 2 (4%)
Fibrosis 1 (2%)
Hyperplasia 1 (2%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Myeloid Cell, Hyperplasia 3 (6%)
Lymph Node (11) (9) (15) (7)
Hemorrhage 1 (9%) 2 (22%) 1 (7%)
Hyperplasia, Lymphoid 1 (7%)
Pigmentation 1 (7%)
Deep Cervical, Hemorrhage 1 (9%) 1 (7%)
Deep Cervical, Hyperplasia, Plasma Cell 1 (7%)
Deep Cervical, Pigmentation 1 (7%)
Iliac, Amyloid Deposition 1 (11%)
Iliac, Hemorrhage 2 (18%) 1 (11%)
Iliac, Pigmentation 1 (11%)
Mediastinal, Hemorrhage 4 (36%) 2 (22%) 7 (47%) 1 (14%)
Mediastinal, Hyperplasia, Lymphoid 1 (7%)
Mediastinal, Hyperplasia, Plasma Cell 1 (7%)
Mediastinal, Inflammation, Acute 1 (11%)
Mediastinal, Pigmentation 2 (18%) 5 (33%)
Pancreatic, Hemorrhage 2 (18%) 2 (13%) 1 (14%)
Pancreatic, Hyperplasia, Histiocytic 1 (9%) 1 (7%)
Pancreatic, Hyperplasia, Lymphoid 1 (7%)
Renal, Hemorrhage 3 (27%) 2 (22%) 4 (27%) 1 (14%)
Renal, Hyperplasia, Histiocytic 1 (9%)
Renal, Pigmentation 1 (9%) 2 (22%) 1 (7%) 1 (14%)
Lymph Node, Mandibular (50) (50) (50) (49)
Amyloid Deposition 1 (2%)
Atrophy 1 (2%)
Ectasia 1 (2%) 1 (2%)
Hemorrhage 6 (12%) 4 (8%) 4 (8%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Plasma Cell 1 (2%) 4 (8%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Pigmentation 1 (2%) 1 (2%) 1 (2%)
Lymph Node, Mesenteric (50) (50) (49) (50)
Atrophy 2 (4%)
Hemorrhage 7 (14%) 3 (6%) 6 (12%) 5 (10%)
Hyperplasia, Histiocytic 3 (6%) 4 (8%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Pigmentation 1 (2%) 1 (2%)
Spleen (50) (50) (50) (49)
Accessory Spleen 1 (2%)
Atrophy 1 (2%)
Congestion 1 (2%)
Fibrosis 3 (6%) 2 (4%) 2 (4%) 1 (2%)
Hematopoietic Cell Proliferation 7 (14%) 2 (4%) 3 (6%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Necrosis 1 (2%)
Pigmentation 7 (14%) 11 (22%) 8 (16%) 10 (20%)
Capsule, Cyst 1 (2%)
Capsule, Fibrosis 2 (4%)
Thymus (48) (49) (50) (50)
Atrophy 16 (33%) 10 (20%) 17 (34%) 14 (28%)
Ectopic Parathyroid Gland 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Epithelial Cell, Hyperplasia 7 (15%) 6 (12%) 9 (18%) 4 (8%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50)
Dilatation 34 (68%) 33 (66%) 25 (51%) 27 (54%)
Hyperplasia 20 (40%) 23 (46%) 14 (29%) 19 (38%)
Inflammation, Chronic Active 1 (2%)
Pigmentation 1 (2%)
Skin (50) (50) (50) (50)
Exudate 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 6 (12%) 7 (14%) 7 (14%) 4 (8%)
Malformation 1 (2%)
Femur, Callus 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Femur, Hyperostosis 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 2 (4%) 2 (4%) 3 (6%) 2 (4%)
Spinal Cord (2) (1)
Hemorrhage 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 2 (4%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 3 (6%) 1 (2%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 3 (6%) 2 (4%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
Mediastinum, Necrosis 1 (2%)
Nose (50) (48) (49) (49)
Foreign Body 1 (2%)
Olfactory Epithelium, Atrophy 1 (2%)
Olfactory Epithelium, Degeneration, Hyaline 2 (4%) 9 (19%) 4 (8%) 3 (6%)
Olfactory Epithelium, Inflammation, Chronic
Active 2 (4%) 2 (4%)
Respiratory Epithelium, Degeneration, Hyaline 6 (12%) 3 (6%) 8 (16%) 12 (24%)
Respiratory Epithelium, Hyperplasia 1 (2%) 10 (21%) 1 (2%) 5 (10%)
Respiratory Epithelium, Inflammation,
Chronic Active 13 (26%) 9 (19%) 18 (37%) 6 (12%)
Respiratory Epithelium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (2)
External Ear, Hyperplasia 1 (50%)
Zymbal's Gland (1) (1)
Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (46) (49) (50) (50)
Casts 1 (2%)
Cyst 1 (2%) 2 (4%)
Hydronephrosis 1 (2%)
Infarct 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 24 (52%) 28 (57%) 26 (52%) 30 (60%)
Nephropathy 23 (50%) 23 (47%) 15 (30%) 20 (40%)
Pelvis, Mineralization 1 (2%)
Renal Tubule, Degeneration, Hyaline 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 2 (4%) 2 (4%) 4 (8%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (49) (50) (50) (49)
Dilatation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 18 14 19 17
Moribund Sacrifice 12 13 7 10
Survivors
Natural Death 1
Terminal Sacrifice 19 23 24 23
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (46) (46) (48) (47)
Hemorrhage 1 (2%)
Parasite Metazoan 1 (2%) 3 (7%) 1 (2%) 2 (4%)
Intestine Large, Rectum (45) (47) (46) (47)
Parasite Metazoan 3 (7%) 3 (6%) 3 (7%) 2 (4%)
Intestine Large, Cecum (45) (46) (45) (44)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Small, Jejunum (39) (42) (41) (42)
Fibrosis 1 (2%)
Intestine Small, Ileum (39) (41) (41) (43)
Parasite Metazoan 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 5 (10%) 11 (22%) 7 (14%) 9 (18%)
Basophilic Focus 3 (6%)
Clear Cell Focus 7 (14%) 8 (16%) 7 (14%) 3 (6%)
Congestion 2 (4%)
Cyst 1 (2%)
Deformity 1 (2%) 2 (4%) 1 (2%)
Degeneration, Cystic 12 (24%) 8 (16%) 12 (24%) 12 (24%)
Eosinophilic Focus 4 (8%) 10 (20%) 10 (20%) 3 (6%)
Hemorrhage 2 (4%)
Hepatodiaphragmatic Nodule 2 (4%) 3 (6%) 5 (10%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mixed Cell Focus 6 (12%) 6 (12%) 2 (4%) 5 (10%)
Necrosis 1 (2%) 2 (4%)
Vacuolization Cytoplasmic 2 (4%) 4 (8%) 1 (2%)
Bile Duct, Hyperplasia 1 (2%) 2 (4%) 3 (6%)
Centrilobular, Congestion 1 (2%)
Centrilobular, Degeneration 1 (2%) 1 (2%)
Centrilobular, Vacuolization Cytoplasmic 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Kupffer Cell, Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Vein, Dilatation 1 (2%)
Mesentery (12) (11) (10) (14)
Accessory Spleen 1 (7%)
Inflammation, Chronic Active 1 (9%)
Necrosis 1 (8%)
Pigmentation 1 (8%)
Fat, Necrosis 9 (75%) 10 (91%) 9 (90%) 12 (86%)
Fat, Pigmentation 1 (10%)
Oral Mucosa (2)
Hyperplasia 1 (50%)
Pancreas (48) (45) (46) (48)
Acinus, Atrophy 10 (21%) 9 (20%) 13 (28%) 12 (25%)
Acinus, Hyperplasia 1 (2%) 3 (6%)
Artery, Hyperplasia 2 (4%)
Salivary Glands (50) (50) (49) (50)
Atrophy 1 (2%)
Duct, Hyperplasia 1 (2%)
Stomach, Forestomach (50) (49) (48) (49)
Diverticulum 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 3 (6%) 2 (4%) 2 (4%)
Ulcer 10 (20%) 10 (20%) 8 (17%) 13 (27%)
Epithelium, Hyperplasia 3 (6%) 4 (8%) 2 (4%) 1 (2%)
Stomach, Glandular (50) (49) (48) (50)
Atrophy 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Necrosis 17 (34%) 14 (29%) 13 (27%) 17 (34%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (48) (50) (50) (50)
Aorta, Inflammation, Chronic Active 1 (2%)
Aorta, Mineralization 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy 35 (70%) 41 (82%) 42 (84%) 33 (66%)
Fibrosis 1 (2%)
Mineralization 2 (4%) 1 (2%)
Thrombosis 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Atrium, Thrombosis 3 (6%) 6 (12%) 4 (8%)
Ventricle, Pigmentation 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (49) (50)
Angiectasis 1 (2%)
Cytoplasmic Alteration 2 (4%) 2 (4%)
Degeneration, Cystic 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Necrosis 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 3 (6%)
Adrenal Medulla (50) (49) (49) (50)
Angiectasis 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 10 (20%) 8 (16%) 8 (16%) 4 (8%)
Islets, Pancreatic (49) (45) (46) (47)
Hyperplasia 1 (2%)
Parathyroid Gland (48) (49) (50) (47)
Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Pituitary Gland (48) (49) (49) (50)
Pars Distalis, Angiectasis 3 (6%) 1 (2%) 3 (6%) 5 (10%)
Pars Distalis, Cyst 1 (2%) 3 (6%) 2 (4%) 2 (4%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 8 (17%) 5 (10%) 5 (10%) 7 (14%)
Pars Intermedia, Cyst 1 (2%) 1 (2%)
Pars Nervosa, Hemorrhage 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Cyst 1 (2%)
C-Cell, Hyperplasia 4 (8%) 6 (12%) 5 (10%) 4 (8%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (3) (1)
Necrosis 1 (33%)
Tissue NOS (1)
Abdominal, Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (49) (50) (50)
Inflammation, Chronic Active 1 (2%)
Penis (1)
Inflammation, Chronic Active 1 (100%)
Preputial Gland (50) (50) (50) (49)
Cyst 3 (6%) 1 (2%) 2 (4%) 3 (6%)
Fibrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 5 (10%) 1 (2%) 3 (6%) 5 (10%)
Prostate (50) (50) (50) (50)
Hyperplasia 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Inflammation, Chronic Active 4 (8%) 5 (10%) 7 (14%) 5 (10%)
Seminal Vesicle (50) (50) (50) (50)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 1 (2%)
Testes (50) (49) (50) (50)
Atrophy 8 (16%) 9 (18%) 12 (24%) 8 (16%)
Artery, Inflammation, Chronic Active 2 (4%) 2 (4%)
Interstitial Cell, Hyperplasia 8 (16%) 11 (22%) 10 (20%) 8 (16%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (47) (45) (47) (49)
Atrophy 4 (9%) 1 (2%) 3 (6%)
Fibrosis 2 (4%)
Hyperplasia 2 (4%) 4 (9%) 2 (4%) 1 (2%)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (24) (23) (23) (24)
Hemorrhage 1 (4%) 1 (4%) 1 (4%)
Iliac, Hemorrhage 1 (4%) 1 (4%)
Iliac, Hyperplasia, Lymphoid 1 (4%)
Iliac, Hyperplasia, Plasma Cell 1 (4%)
Mediastinal, Congestion 1 (4%)
Mediastinal, Ectasia 1 (4%)
Mediastinal, Hemorrhage 11 (46%) 11 (48%) 8 (35%) 11 (46%)
Mediastinal, Hyperplasia, Lymphoid 3 (13%) 2 (9%)
Mediastinal, Hyperplasia, Plasma Cell 1 (4%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (4%) 1 (4%)
Mediastinal, Pigmentation 3 (13%) 2 (9%) 1 (4%)
Pancreatic, Ectasia 1 (4%)
Pancreatic, Hemorrhage 1 (4%) 4 (17%) 2 (9%) 5 (21%)
Pancreatic, Hyperplasia, Lymphoid 1 (4%)
Renal, Ectasia 3 (13%)
Renal, Hemorrhage 3 (13%) 3 (13%) 1 (4%) 8 (33%)
Renal, Hyperplasia, Lymphoid 1 (4%)
Renal, Hyperplasia, Plasma Cell 1 (4%)
Renal, Pigmentation 3 (13%) 4 (17%) 2 (9%) 7 (29%)
Lymph Node, Mandibular (50) (50) (50) (50)
Ectasia 1 (2%) 8 (16%) 2 (4%) 3 (6%)
Hemorrhage 3 (6%) 1 (2%) 3 (6%) 2 (4%)
Hyperplasia, Lymphoid 5 (10%) 2 (4%) 3 (6%) 2 (4%)
Hyperplasia, Plasma Cell 2 (4%) 4 (8%) 5 (10%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Infiltration Cellular, Histiocyte 1 (2%)
Lymph Node, Mesenteric (49) (50) (50) (50)
Ectasia 3 (6%) 1 (2%) 2 (4%) 1 (2%)
Hemorrhage 4 (8%) 4 (8%) 4 (8%) 6 (12%)
Hyperplasia, Lymphoid 4 (8%) 2 (4%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
Spleen (50) (50) (50) (50)
Angiectasis 2 (4%)
Atrophy 1 (2%)
Congestion 3 (6%) 2 (4%)
Cyst 1 (2%)
Fibrosis 10 (20%) 16 (32%) 19 (38%) 14 (28%)
Hematopoietic Cell Proliferation 3 (6%) 5 (10%) 2 (4%) 2 (4%)
Necrosis 3 (6%) 1 (2%) 2 (4%) 1 (2%)
Pigmentation 2 (4%) 2 (4%) 2 (4%)
Capsule, Fibrosis 2 (4%) 2 (4%) 2 (4%)
Capsule, Pigmentation 1 (2%) 1 (2%)
Thymus (49) (47) (48) (47)
Atrophy 30 (61%) 19 (40%) 18 (38%) 27 (57%)
Hemorrhage 3 (6%) 3 (6%) 2 (4%)
Epithelial Cell, Hyperplasia 5 (10%) 3 (6%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (45) (48) (47)
Dilatation 8 (16%) 13 (29%) 9 (19%) 6 (13%)
Hyperplasia 1 (2%) 3 (7%) 5 (10%) 6 (13%)
Inflammation, Chronic Active 2 (4%)
Pigmentation 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Hyperkeratosis 2 (4%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%)
Ulcer 2 (4%)
Epidermis, Hyperplasia 1 (2%)
Hair Follicle, Atrophy 1 (2%)
Subcutaneous Tissue, Fibrosis 1 (2%)
Subcutaneous Tissue, Foreign Body 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%) 2 (4%) 1 (2%) 4 (8%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Meninges, Angiectasis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%) 4 (8%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic Active 3 (6%) 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 1 (2%) 6 (12%) 1 (2%)
Alveolus, Metaplasia, Squamous 1 (2%)
Nose (50) (47) (49) (50)
Foreign Body 2 (4%) 1 (2%)
Nasopharyngeal Duct, Inflammation, Chronic
Active 1 (2%)
Olfactory Epithelium, Degeneration, Hyaline 1 (2%) 2 (4%)
Olfactory Epithelium, Foreign Body 1 (2%) 1 (2%)
Olfactory Epithelium, Hyperplasia 1 (2%)
Olfactory Epithelium, Inflammation, Chronic
Active 10 (20%) 2 (4%) 6 (12%) 5 (10%)
Olfactory Epithelium, Metaplasia 1 (2%)
Respiratory Epithelium, Degeneration, Hyaline 2 (4%) 1 (2%)
Respiratory Epithelium, Foreign Body 3 (6%)
Respiratory Epithelium, Hyperplasia 22 (44%) 20 (43%) 16 (33%) 28 (56%)
Respiratory Epithelium, Inflammation 1 (2%)
Respiratory Epithelium, Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Respiratory Epithelium, Inflammation,
Chronic Active 22 (44%) 15 (32%) 22 (45%) 27 (54%)
Respiratory Epithelium, Metaplasia 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%) 1 (2%)
Respiratory Epithelium, Thrombosis 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2)
Atrophy 2 (100%)
Hemorrhage 1 (100%)
Lens, Cataract 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49) (50)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Cyst 3 (6%) 2 (4%) 3 (6%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Hydronephrosis 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Mineralization 2 (4%) 1 (2%)
Necrosis 1 (2%)
Nephropathy 46 (92%) 46 (94%) 46 (94%) 49 (98%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 4 (8%) 3 (6%) 4 (8%) 3 (6%)
Urinary Bladder (48) (50) (49) (49)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
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