NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:36:37
2 YEAR CHRONIC
Facility: TSI Mason Research
Chemical CAS #: 127-00-4
Lock Date: 05/25/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:36:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 12 7 7 5
Natural Death 13 10 13 14
Survivors
Terminal Sacrifice 25 33 30 31
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (47) (49) (48) (48)
Intestine Small, Jejunum (44) (44) (43) (46)
Intestine Small, Ileum (42) (45) (43) (45)
Liver (50) (50) (50) (50)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mesentery (9) (11) (12) (10)
Histiocytic Sarcoma 1 (11%)
Oral Mucosa (1) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%)
Pancreas (47) (49) (49) (48)
Histiocytic Sarcoma 1 (2%)
Acinus, Adenoma 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Stomach, Glandular (50) (50) (50) (50)
Tongue (2) (2) (1)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (50%)
Squamous Cell Papilloma 2 (100%) 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:36:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Carcinoma 1 (2%)
Adrenal Medulla (49) (50) (50) (50)
Ganglioneuroma 1 (2%)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 2 (4%) 4 (8%) 1 (2%) 4 (8%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (46) (49) (48) (48)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (49) (50) (50) (50)
Pars Distalis, Adenoma 29 (59%) 30 (60%) 32 (64%) 35 (70%)
Pars Distalis, Carcinoma 1 (2%)
Pars Distalis, Histiocytic Sarcoma 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
C-Cell, Adenoma 2 (4%) 8 (16%) 5 (10%) 3 (6%)
C-Cell, Carcinoma 1 (2%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Abdominal, Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (49) (49) (49)
Adenoma 1 (2%) 2 (4%) 4 (8%)
Carcinoma 2 (4%) 3 (6%) 2 (4%) 3 (6%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Bilateral, Carcinoma 2 (4%) 1 (2%)
Ovary (50) (50) (50) (50)
Cystadenoma 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Granulosa-Theca Tumor Malignant 1 (2%)
Histiocytic Sarcoma 1 (2%)
Uterus (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Polyp Stromal 6 (12%) 6 (12%) 6 (12%) 4 (8%)
Bilateral, Polyp Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:36:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (47) (50) (47) (49)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymph Node (11) (9) (15) (7)
Mediastinal, Histiocytic Sarcoma 1 (7%)
Pancreatic, Histiocytic Sarcoma 1 (7%)
Lymph Node, Mandibular (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (50) (50) (49) (50)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Thymus (48) (49) (50) (50)
Histiocytic Sarcoma 1 (2%)
Thymoma Benign 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Fibroadenoma 21 (42%) 21 (42%) 26 (53%) 14 (28%)
Fibroadenoma, Multiple 8 (16%) 7 (14%) 5 (10%) 9 (18%)
Histiocytic Sarcoma 1 (2%)
Skin (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Melanoma Malignant 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:36:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Melanoma Malignant, Metastatic, Skin 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Complex, Metastatic,
Adrenal Medulla 1 (2%)
Nose (50) (48) (49) (49)
Respiratory Epithelium, Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (46) (49) (50) (50)
Mesenchymal Tumor Malignant 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
Urinary Bladder (49) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Leukemia Mononuclear 19 (38%) 19 (38%) 18 (36%) 13 (26%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:36:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 46 49 48
Total Primary Neoplasms 107 111 112 104
Total Animals with Benign Neoplasms 43 42 48 42
Total Benign Neoplasms 76 81 83 83
Total Animals with Malignant Neoplasms 26 24 26 18
Total Malignant Neoplasms 31 30 29 21
Total Animals with Metastatic Neoplasms 1 2 1
Total Metastatic Neoplasm 1 2 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:36:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 18 14 19 17
Moribund Sacrifice 12 13 7 10
Survivors
Natural Death 1
Terminal Sacrifice 19 23 24 23
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Intestine Large, Colon (46) (46) (48) (47)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Intestine Large, Cecum (45) (46) (45) (44)
Intestine Small, Duodenum (46) (45) (46) (48)
Intestine Small, Jejunum (39) (42) (41) (42)
Intestine Small, Ileum (39) (41) (41) (43)
Liver (50) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Hepatocellular Adenoma 1 (2%) 3 (6%) 1 (2%) 2 (4%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mesentery (12) (11) (10) (14)
Lipoma 1 (7%)
Oral Mucosa (2)
Squamous Cell Papilloma 1 (50%)
Pancreas (48) (45) (46) (48)
Acinus, Adenoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Salivary Glands (50) (50) (49) (50)
Histiocytic Sarcoma 1 (2%)
Stomach, Forestomach (50) (49) (48) (49)
Stomach, Glandular (50) (49) (48) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (48) (50) (50) (50)
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:36:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (49) (50)
Carcinoma 1 (2%)
Adrenal Medulla (50) (49) (49) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 2 (4%)
Pheochromocytoma Benign 7 (14%) 13 (27%) 13 (27%) 11 (22%)
Bilateral, Pheochromocytoma Benign 6 (12%) 1 (2%) 4 (8%) 1 (2%)
Islets, Pancreatic (49) (45) (46) (47)
Adenoma 2 (4%) 1 (2%) 2 (4%) 3 (6%)
Carcinoma 1 (2%)
Pituitary Gland (48) (49) (49) (50)
Pars Distalis, Adenoma 15 (31%) 20 (41%) 25 (51%) 24 (48%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Adenoma 5 (10%) 1 (2%) 6 (12%) 3 (6%)
C-Cell, Carcinoma 2 (4%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (3) (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (49) (50) (50)
Preputial Gland (50) (50) (50) (49)
Adenoma 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Carcinoma 1 (2%) 4 (8%) 4 (8%) 3 (6%)
Bilateral, Carcinoma 1 (2%)
Prostate (50) (50) (50) (50)
Adenoma 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Testes (50) (49) (50) (50)
Bilateral, Interstitial Cell, Adenoma 36 (72%) 32 (65%) 31 (62%) 34 (68%)
Interstitial Cell, Adenoma 10 (20%) 11 (22%) 9 (18%) 12 (24%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (47) (45) (47) (49)
Lymph Node (24) (23) (23) (24)
Iliac, Squamous Cell Carcinoma, Metastatic,
Skin 1 (4%)
Lymph Node, Mandibular (50) (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Page 8
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:36:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Squamous Cell Carcinoma, Metastatic,
Uncertain Primary Site 1 (2%)
Lymph Node, Mesenteric (49) (50) (50) (50)
Spleen (50) (50) (50) (50)
Thymus (49) (47) (48) (47)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (45) (48) (47)
Fibroadenoma 7 (14%) 5 (10%) 6 (13%)
Fibroadenoma, Multiple 1 (2%)
Skin (50) (50) (50) (50)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 2 (4%) 3 (6%) 3 (6%) 6 (12%)
Keratoacanthoma, Multiple 1 (2%)
Squamous Cell Carcinoma, Multiple 1 (2%)
Squamous Cell Papilloma 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 3 (6%) 8 (16%) 7 (14%) 6 (12%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Melanoma Malignant 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Vertebra, Osteosarcoma 1 (2%)
Skeletal Muscle (2) (1)
Histiocytic Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:36:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 1 (2%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Nose (50) (47) (49) (50)
Histiocytic Sarcoma 1 (2%)
Respiratory Epithelium, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Histiocytic Sarcoma 1 (100%)
Zymbal's Gland (1) (3) (3)
Carcinoma 1 (100%) 3 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49) (50)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (48) (50) (49) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leukemia Mononuclear 32 (64%) 33 (66%) 30 (60%) 31 (62%)
Mesothelioma Malignant 3 (6%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05160-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:36:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 325 PPM 650 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 50 50 50
Total Primary Neoplasms 141 148 156 161
Total Animals with Benign Neoplasms 48 48 48 50
Total Benign Neoplasms 99 101 112 116
Total Animals with Malignant Neoplasms 39 38 37 37
Total Malignant Neoplasms 42 47 44 45
Total Animals with Metastatic Neoplasms 3 4 1
Total Metastatic Neoplasm 3 5 1
Total Animals with Malignant Neoplasms 2 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
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