TDMS Study 05160-05 Pathology Tables
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
2 YEAR CHRONIC
Facility: TSI Mason Research
Chemical CAS #: 127-00-4
Lock Date: 05/25/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 7| 7| 8| 2| 2| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3|
| 5| 4| 4| 2| 4| 0| 5| 4| 4| 5| 2| 2| 0| 0| 9| 4| 5| 5| 9| 5| 5| 7| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 3 1 2 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + A + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Deformity | X |
Eosinophilic Focus | X X X |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Lymphocyte | 1|
Inflammation, Granulomatous | 1 1 1 1 1 1 1 |
Mixed Cell Focus | X X |
Necrosis | |
Pigmentation, Bile | 2 |
Vacuolization Cytoplasmic | 4 |
Artery, Thrombosis | |
Bile Duct, Hyperplasia | 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + |
Hemorrhage | 2 |
Fat, Necrosis | 3 4 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 1 1 1 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 |
Ulcer | 2 |
Epithelium, Hyperplasia | 2 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Necrosis | 1 2 2 1 4 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 7| 7| 8| 2| 2| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3|
| 5| 4| 4| 2| 4| 0| 5| 4| 4| 5| 2| 2| 0| 0| 9| 4| 5| 5| 9| 5| 5| 7| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 2 2 1 1 |
Inflammation, Chronic Active | |
Artery, Inflammation, Chronic Active | |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2|
Cytoplasmic Alteration | 1 |
Hemorrhage | |
Vacuolization Cytoplasmic | 4 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Infiltration Cellular, Lymphocyte | 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + A + + + + + + + + + + + +|
Metaplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 3 3 2 2 2|
Pars Distalis, Hemorrhage | 2 2 |
Pars Distalis, Hyperplasia | 3 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic Active | |
C-Cell, Hyperplasia | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2|
Hyperplasia | 3 |
Inflammation, Chronic Active | 2 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 3 2 |
Bilateral, Cyst | 4|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hemorrhage | 4 |
Hydrometra | 3 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 7| 7| 8| 2| 2| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3|
| 5| 4| 4| 2| 4| 0| 5| 4| 4| 5| 2| 2| 0| 0| 9| 4| 5| 5| 9| 5| 5| 7| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Hemorrhage | 4 |
Deep Cervical, Hemorrhage | 2 |
Iliac, Hemorrhage | 4 |
Mediastinal, Hemorrhage | 2 2 |
Mediastinal, Pigmentation | 2 |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Hyperplasia, Histiocytic | |
Renal, Hemorrhage | 2 |
Renal, Hyperplasia, Histiocytic | 2 |
Renal, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Ectasia | 2 |
Hemorrhage | 1 2 3 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hemorrhage | 2 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Congestion | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 |
Pigmentation | 2 1 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + A + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 3 3 4 3 2 2 3 |
Ectopic Parathyroid Gland | 2 |
Hemorrhage | |
Epithelial Cell, Hyperplasia | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 4 1 2 2 4 2 1 3 4 2 2 4 1 2 2|
Hyperplasia | 2 2 3 2 2 2 1 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 7| 7| 8| 2| 2| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3|
| 5| 4| 4| 2| 4| 0| 5| 4| 4| 5| 2| 2| 0| 0| 9| 4| 5| 5| 9| 5| 5| 7| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 4 3 3 |
Femur, Callus | |
Femur, Hyperostosis | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic Active | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Artery, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Olfactory Epithelium, Inflammation, | |
Chronic Active | 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Inflammation,| |
Chronic Active | 4 1 3 4 4 3 3 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + A + + + + + + A + + + + + + + + + + + +|
Cyst | 4 |
Infarct | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 7| 7| 8| 2| 2| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3|
| 5| 4| 4| 2| 4| 0| 5| 4| 4| 5| 2| 2| 0| 0| 9| 4| 5| 5| 9| 5| 5| 7| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 4 1 1 1 2 2 1 1 1 3 1 |
Pelvis, Mineralization | 1 |
Renal Tubule, Degeneration, Hyaline | 3 |
Renal Tubule, Pigmentation | 2 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 0| 2| 5| 3| 2| 2| 3| 1| 3| 9| 3| 4| 3| 2| 5| 3| 0| 1| 4| 3| 3| 4| 8| |
| 4| 4| 9| 9| 3| 4| 9| 7| 5| 9| 5| 8| 4| 1| 4| 2| 9| 4| 1| 9| 1| 4| 4| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + A + + + + + + + + + + + + +| 47 |
Parasite Metazoan | | 3 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 1 | 6 1.5|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + A + + + + + + + + + + + + +| 47 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + A + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + A + + + + + + A + A + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + A + + + + + + A A A + + + +| 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X | 29 |
Clear Cell Focus | X X | 3 |
Deformity | X X | 3 |
Eosinophilic Focus | X X X | 6 |
Hemorrhage | 3 | 2 3.0|
Hepatodiaphragmatic Nodule | X | 2 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Granulomatous | 1 1 1 1 1 | 12 1.0|
Mixed Cell Focus | X X | 4 |
Necrosis | 3 2 2 | 3 2.3|
Pigmentation, Bile | | 1 2.0|
Vacuolization Cytoplasmic | | 1 4.0|
Artery, Thrombosis | 4 | 1 4.0|
Bile Duct, Hyperplasia | | 1 1.0|
Centrilobular, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Hemorrhage | | 1 2.0|
Fat, Necrosis | 4 4 4 2 | 8 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + A + + + + + + + + + + + + +| 47 |
Acinus, Atrophy | 1 2 2 2 3 2 1| 12 1.9|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 | 5 1.4|
Ulcer | 4 | 2 3.0|
Epithelium, Hyperplasia | 2 | 4 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 0| 2| 5| 3| 2| 2| 3| 1| 3| 9| 3| 4| 3| 2| 5| 3| 0| 1| 4| 3| 3| 4| 8| |
| 4| 4| 9| 9| 3| 4| 9| 7| 5| 9| 5| 8| 4| 1| 4| 2| 9| 4| 1| 9| 1| 4| 4| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis | 2 3 3 2 2 2 2 | 12 2.2|
__________________________________________________________________________|____________|
Tongue | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 | 18 1.1|
Inflammation, Chronic Active | 3 | 1 3.0|
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
Atrium, Thrombosis | 4 2 2 | 4 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 2 2 1 | 7 1.7|
Cytoplasmic Alteration | 1 1 1 1 | 5 1.0|
Hemorrhage | 3 4 | 2 3.5|
Vacuolization Cytoplasmic | 2 4 | 4 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 2 3 | 5 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + + A + + + + + + + + + + + + +| 46 |
Metaplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 4 | 1 4.0|
Pars Distalis, Cyst | 2 4 1 3 3 2 3 1 | 13 2.4|
Pars Distalis, Hemorrhage | | 2 2.0|
Pars Distalis, Hyperplasia | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Chronic Active | 1 | 1 1.0|
C-Cell, Hyperplasia | 4 2 2 1 | 10 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Cyst | 1 2 | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 0| 2| 5| 3| 2| 2| 3| 1| 3| 9| 3| 4| 3| 2| 5| 3| 0| 1| 4| 3| 3| 4| 8| |
| 4| 4| 9| 9| 3| 4| 9| 7| 5| 9| 5| 8| 4| 1| 4| 2| 9| 4| 1| 9| 1| 4| 4| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | 4 | 3 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Cyst | 4 4 2 3 | 6 3.0|
Bilateral, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Hemorrhage | | 1 4.0|
Hydrometra | 4 2 | 4 2.8|
Hyperplasia, Cystic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + + + + A + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Myeloid Cell, Hyperplasia | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + +| 11 |
Hemorrhage | | 1 4.0|
Deep Cervical, Hemorrhage | | 1 2.0|
Iliac, Hemorrhage | 4 | 2 4.0|
Mediastinal, Hemorrhage | 3 4 | 4 2.8|
Mediastinal, Pigmentation | 2| 2 2.0|
Pancreatic, Hemorrhage | 4 | 2 3.0|
Pancreatic, Hyperplasia, Histiocytic | 2 | 1 2.0|
Renal, Hemorrhage | 2 4 | 3 2.7|
Renal, Hyperplasia, Histiocytic | | 1 2.0|
Renal, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Ectasia | | 1 2.0|
Hemorrhage | 1 3 2 | 6 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 2 3.0|
Hemorrhage | 1 1 4 2 | 7 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 0| 2| 5| 3| 2| 2| 3| 1| 3| 9| 3| 4| 3| 2| 5| 3| 0| 1| 4| 3| 3| 4| 8| |
| 4| 4| 9| 9| 3| 4| 9| 7| 5| 9| 5| 8| 4| 1| 4| 2| 9| 4| 1| 9| 1| 4| 4| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Atrophy | | 1 4.0|
Congestion | 3 | 1 3.0|
Fibrosis | 3 3 | 3 2.7|
Hematopoietic Cell Proliferation | 3 1 3 2 | 7 2.1|
Pigmentation | 2 1 | 7 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Atrophy | 2 2 2 3 3 3 | 16 2.6|
Ectopic Parathyroid Gland | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Epithelial Cell, Hyperplasia | 2 2 2 2 2 | 7 2.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 3 2 3 2 4 3 2 1 2 3 1 4 1 2 2 4 2| 34 2.4|
Hyperplasia | 3 2 3 4 1 2 4 2 3 1 3 1| 20 2.3|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 4 2 | 6 3.3|
Femur, Callus | 2 | 1 2.0|
Femur, Hyperostosis | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic Active | 1 1 4 | 3 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
Artery, Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 0| 2| 5| 3| 2| 2| 3| 1| 3| 9| 3| 4| 3| 2| 5| 3| 0| 1| 4| 3| 3| 4| 8| |
| 4| 4| 9| 9| 3| 4| 9| 7| 5| 9| 5| 8| 4| 1| 4| 2| 9| 4| 1| 9| 1| 4| 4| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 | 2 1.0|
Olfactory Epithelium, Inflammation, | | |
Chronic Active | 1 | 2 1.5|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 | 6 1.0|
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
Respiratory Epithelium, Inflammation,| | |
Chronic Active | 1 4 3 1 | 13 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + A + + + + A + + + + + + + + + + + + +| 46 |
Cyst | | 1 4.0|
Infarct | 1 | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 24 1.0|
Nephropathy | 2 3 1 2 2 1 4 1 1 2 4 | 23 1.8|
Pelvis, Mineralization | | 1 1.0|
Renal Tubule, Degeneration, Hyaline | | 1 3.0|
Renal Tubule, Pigmentation | 2 | 2 2.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 1| 9| 3| 7| 3| 8| 3| 3| 0| 3| 3| 3| 2| 0| 3| 2| 1| 3| 3| 3| 3| 3| 3|
| 7| 4| 2| 9| 4| 6| 4| 2| 4| 4| 8| 4| 4| 4| 7| 8| 4| 8| 2| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 3 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + + + + + + + + + A + + A A + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + + + + + + + + + + + + A A + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Congestion | 3 3 |
Deformity | X X X|
Eosinophilic Focus | X X|
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Granulomatous | 1 1 1 |
Mixed Cell Focus | X X X X X |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 2|
Kupffer Cell, Pigmentation | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Acinus, Atrophy | 1 1 |
Acinus, Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Ulcer | 2 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 2 3 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 1| 9| 3| 7| 3| 8| 3| 3| 0| 3| 3| 3| 2| 0| 3| 2| 1| 3| 3| 3| 3| 3| 3|
| 7| 4| 2| 9| 4| 6| 4| 2| 4| 4| 8| 4| 4| 4| 7| 8| 4| 8| 2| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 2 1 1 2|
Atrium, Inflammation, Chronic Active | |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 2 1 |
Cytoplasmic Alteration | 1 |
Degeneration, Cystic | 2 |
Hemorrhage | 2 |
Vacuolization Cytoplasmic | 1 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 2 3 1 2 2 1 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 3 1 2 |
Pars Nervosa, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 2 |
Hyperplasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 |
Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 1| 9| 3| 7| 3| 8| 3| 3| 0| 3| 3| 3| 2| 0| 3| 2| 1| 3| 3| 3| 3| 3| 3|
| 7| 4| 2| 9| 4| 6| 4| 2| 4| 4| 8| 4| 4| 4| 7| 8| 4| 8| 2| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hemorrhage | |
Inflammation, Chronic Active | 4 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Vagina | |
Hemorrhage | |
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Chronic Active | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Hemorrhage | 4 |
Iliac, Amyloid Deposition | 3 |
Iliac, Hemorrhage | 3 |
Iliac, Pigmentation | |
Mediastinal, Hemorrhage | |
Mediastinal, Inflammation, Acute | 3 |
Renal, Hemorrhage | 3 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Hemorrhage | 3 1 4 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 1 |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Histiocytic | |
Pigmentation | 2 2 2 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Atrophy | 2 3 3 2 2 2 |
Hemorrhage | |
Epithelial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 4 1 4 3 1 1 1 3 1 3 1 1 2 2 2|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 1| 9| 3| 7| 3| 8| 3| 3| 0| 3| 3| 3| 2| 0| 3| 2| 1| 3| 3| 3| 3| 3| 3|
| 7| 4| 2| 9| 4| 6| 4| 2| 4| 4| 8| 4| 4| 4| 7| 8| 4| 8| 2| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia | 2 2 3 1 4 1 1 1 2 2 2 |
Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 |
Inflammation, Chronic Active | 1 |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 1 3 1|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | A + + + + + + + + + + + + + + + + + A + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 |
Olfactory Epithelium, Inflammation, | |
Chronic Active | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 |
Respiratory Epithelium, Inflammation,| |
Chronic Active | 3 1 2 1 2|
Respiratory Epithelium, Thrombosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Zymbal's Gland | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 1| 9| 3| 7| 3| 8| 3| 3| 0| 3| 3| 3| 2| 0| 3| 2| 1| 3| 3| 3| 3| 3| 3|
| 7| 4| 2| 9| 4| 6| 4| 2| 4| 4| 8| 4| 4| 4| 7| 8| 4| 8| 2| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 1 1 1 1 1 2 1 1 2|
Renal Tubule, Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 3| 1| 3| 3| 1| 7| 7| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 4| 7| 4| 4| 6| 8| 8| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
150 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 | 1 3.0|
Parasite Metazoan | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 4 1.8|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 | 1 3.0|
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 | 5 1.6|
Basophilic Focus | X X X X X X X X X X X X X X X X X X | 33 |
Clear Cell Focus | X X X X | 7 |
Congestion | | 2 3.0|
Deformity | X X X | 6 |
Eosinophilic Focus | X | 3 |
Hepatodiaphragmatic Nodule | X X | 3 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Granulomatous | 1 1 | 5 1.0|
Mixed Cell Focus | X X X | 8 |
Necrosis | 2 | 2 2.0|
Vacuolization Cytoplasmic | | 2 2.0|
Kupffer Cell, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + +| 11 |
Fat, Necrosis | 2 4 2 4 3 3 3 3| 10 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | | 1 2.0|
Acinus, Atrophy | 1 1 | 4 1.0|
Acinus, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 3| 1| 3| 3| 1| 7| 7| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 4| 7| 4| 4| 6| 8| 8| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
150 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 2 2.0|
Epithelium, Hyperplasia | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 1 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Tongue | + | 2 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Developmental Malformation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 | 21 1.1|
Atrium, Inflammation, Chronic Active | 2 | 1 2.0|
Atrium, Thrombosis | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 1 | 8 1.4|
Cytoplasmic Alteration | 1 1 | 3 1.0|
Degeneration, Cystic | | 1 2.0|
Hemorrhage | 1 2 | 3 1.7|
Vacuolization Cytoplasmic | 3 2 1 | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 2 2 2 1 | 11 1.8|
Pars Distalis, Hemorrhage | 2| 1 2.0|
Pars Distalis, Hyperplasia | 2 3 3 | 6 2.3|
Pars Nervosa, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 2 1 1 3 | 11 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 3| 1| 3| 3| 1| 7| 7| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 4| 7| 4| 4| 6| 8| 8| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
150 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Cyst | 2 | 4 2.3|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 | 4 2.8|
Hyperplasia, Histiocytic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Hemorrhage | 4 | 1 4.0|
Inflammation, Chronic Active | | 1 4.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Vagina | + + | 2 |
Hemorrhage | 4 | 1 4.0|
Infiltration Cellular, | | |
Polymorphonuclear | 4 | 1 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Pigmentation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 9 |
Hemorrhage | 2 | 2 3.0|
Iliac, Amyloid Deposition | | 1 3.0|
Iliac, Hemorrhage | | 1 3.0|
Iliac, Pigmentation | 3 | 1 3.0|
Mediastinal, Hemorrhage | 2 2 | 2 2.0|
Mediastinal, Inflammation, Acute | | 1 3.0|
Renal, Hemorrhage | 2 | 2 2.5|
Renal, Pigmentation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | | 1 4.0|
Hemorrhage | 2 | 4 2.5|
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 3 1.7|
Hyperplasia, Histiocytic | 2 2 | 3 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 3| 1| 3| 3| 1| 7| 7| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 4| 7| 4| 4| 6| 8| 8| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
150 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 2 1.5|
Hematopoietic Cell Proliferation | 3 2 | 2 2.5|
Hyperplasia, Histiocytic | 4 | 1 4.0|
Pigmentation | 2 2 3 2 3 | 11 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 2 2 2| 10 2.2|
Hemorrhage | 2 | 1 2.0|
Epithelial Cell, Hyperplasia | 2 2 2 3 | 6 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 2 2 1 1 2 1 3 2 4 1 1 1 2 3 4 | 33 2.1|
Hyperplasia | 2 2 2 1 2 2 2 1 4 2 1 3 | 23 2.0|
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 4 4 3 | 7 2.7|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 4.0|
Artery, Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 2 2 1 | 9 1.3|
Olfactory Epithelium, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 3| 1| 3| 3| 1| 7| 7| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 4| 7| 4| 4| 6| 8| 8| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
150 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Chronic Active | 1 1 | 2 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 3 1.0|
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 | 10 1.0|
Respiratory Epithelium, Inflammation,| | |
Chronic Active | 2 3 1 1| 9 1.8|
Respiratory Epithelium, Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 23 1.1|
Renal Tubule, Pigmentation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 1| 3| 0| 5| 1| 3| 3| 3| 3| 3| 3| 6| 3| 7| 2| 3| 3| 3| 3| 3| 3|
| 3| 4| 4| 4| 8| 4| 8| 5| 7| 4| 4| 4| 4| 4| 4| 8| 4| 1| 8| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
325 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + A + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Deformity | X X |
Eosinophilic Focus | X X X X |
Hepatodiaphragmatic Nodule | X X X X|
Infiltration Cellular, Lymphocyte | |
Inflammation, Granulomatous | 1 1 1 1 1 1|
Mixed Cell Focus | X X X X |
Necrosis | 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 4 3 3 4 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 2 |
Acinus, Atrophy | 4 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 2 3 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 |
Atrium, Thrombosis | 3 2 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 1| 3| 0| 5| 1| 3| 3| 3| 3| 3| 3| 6| 3| 7| 2| 3| 3| 3| 3| 3| 3|
| 3| 4| 4| 4| 8| 4| 8| 5| 7| 4| 4| 4| 4| 4| 4| 8| 4| 1| 8| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
325 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 2 2|
Cytoplasmic Alteration | 1 |
Degeneration, Cystic | 1 |
Vacuolization Cytoplasmic | 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 1 2 1 2 2 2 3 2 2 |
Pars Distalis, Hyperplasia | 3 3 4 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 3 |
Inflammation, Chronic Active | |
Bilateral, Cyst | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 3 3 3 4 1 1 4|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Cyst | |
Hemorrhage | 4 |
Hydrometra | 4 3 2 |
Hyperplasia, Cystic | 2 |
Inflammation, Chronic Active | 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + A + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 1| 3| 0| 5| 1| 3| 3| 3| 3| 3| 3| 6| 3| 7| 2| 3| 3| 3| 3| 3| 3|
| 3| 4| 4| 4| 8| 4| 8| 5| 7| 4| 4| 4| 4| 4| 4| 8| 4| 1| 8| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
325 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Deep Cervical, Hemorrhage | 2 |
Deep Cervical, Hyperplasia, Plasma | |
Cell | 3 |
Deep Cervical, Pigmentation | 2 |
Mediastinal, Hemorrhage | 3 2 3 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
Mediastinal, Pigmentation | 2 1 |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Hyperplasia, Histiocytic | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hemorrhage | 2 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 |
Hemorrhage | 2 1 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 2 3 3 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 2 |
Hyperplasia, Histiocytic | 2 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 3 |
Pigmentation | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 2 2 3 2 |
Hemorrhage | 2 |
Epithelial Cell, Hyperplasia | 1 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Dilatation | 1 2 2 1 2 3 4 1 1 2 2 2 2 |
Hyperplasia | 3 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 2 2 |
Malformation | X |
Femur, Hyperostosis | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 1| 3| 0| 5| 1| 3| 3| 3| 3| 3| 3| 6| 3| 7| 2| 3| 3| 3| 3| 3| 3|
| 3| 4| 4| 4| 8| 4| 8| 5| 7| 4| 4| 4| 4| 4| 4| 8| 4| 1| 8| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
325 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 1 |
__________________________________________________________________________|
Nose | A + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Inflammation,| |
Chronic Active | 4 1 3 2 4 2 2 2 1 1 3|
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts | 2 |
Inflammation, Acute | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy | 1 1 1 1 |
Renal Tubule, Degeneration, Hyaline | |
Renal Tubule, Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 3| 3| 3| 3| 0| 3| 3| 1| 3| 2| 9| 3| 3| 3| 5| 3| 0| 6| 9| 2| 3| 3| |
| 3| 7| 4| 4| 4| 4| 5| 6| 5| 3| 4| 4| 5| 7| 4| 4| 4| 9| 4| 8| 1| 4| 1| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
325 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 | 1 1.0|
Parasite Metazoan | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 3 1.7|
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A A + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A + + + + + + + A + + A + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + + + + + + A + + A + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 | 3 2.0|
Basophilic Focus | X X X X X X X X X X| 27 |
Clear Cell Focus | X X X X X| 7 |
Deformity | X | 3 |
Eosinophilic Focus | X X X | 7 |
Hepatodiaphragmatic Nodule | X X X X X X X X| 12 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Inflammation, Granulomatous | 1 1 1 | 9 1.0|
Mixed Cell Focus | X | 5 |
Necrosis | 3 1 1 2 | 5 1.6|
Vacuolization Cytoplasmic | 2 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 12 |
Fat, Necrosis | 4 3 3 4 3 4 4 | 11 3.5|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Mixed Cell | | 1 2.0|
Acinus, Atrophy | 1 | 3 2.0|
Acinus, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 4 | 3 4.0|
Epithelium, Hyperplasia | 3 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 1 1 3 | 7 2.1|
Ulcer | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 3| 3| 3| 3| 0| 3| 3| 1| 3| 2| 9| 3| 3| 3| 5| 3| 0| 6| 9| 2| 3| 3| |
| 3| 7| 4| 4| 4| 4| 5| 6| 5| 3| 4| 4| 5| 7| 4| 4| 4| 9| 4| 8| 1| 4| 1| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
325 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 1 1 2 1 1 2| 15 1.3|
Atrium, Thrombosis | 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 2 3 | 9 2.0|
Cytoplasmic Alteration | | 1 1.0|
Degeneration, Cystic | | 1 1.0|
Vacuolization Cytoplasmic | 3 1 2 3 | 7 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 2 2 2 | 4 2.0|
Pars Distalis, Cyst | 2 2 | 11 1.9|
Pars Distalis, Hyperplasia | 2 2 | 6 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 3 3 2 1 | 6 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 3 2 | 4 2.5|
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Bilateral, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 10 2.8|
Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 3.0|
Cyst | 3 3 | 2 3.0|
Hemorrhage | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 3| 3| 3| 3| 0| 3| 3| 1| 3| 2| 9| 3| 3| 3| 5| 3| 0| 6| 9| 2| 3| 3| |
| 3| 7| 4| 4| 4| 4| 5| 6| 5| 3| 4| 4| 5| 7| 4| 4| 4| 9| 4| 8| 1| 4| 1| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
325 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hydrometra | | 3 3.0|
Hyperplasia, Cystic | | 1 2.0|
Inflammation, Chronic Active | 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 15 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Pigmentation | 2 | 1 2.0|
Deep Cervical, Hemorrhage | | 1 2.0|
Deep Cervical, Hyperplasia, Plasma | | |
Cell | | 1 3.0|
Deep Cervical, Pigmentation | | 1 2.0|
Mediastinal, Hemorrhage | 2 2 2 | 7 2.3|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
Mediastinal, Pigmentation | 2 2 2 | 5 1.8|
Pancreatic, Hemorrhage | 2 | 2 2.0|
Pancreatic, Hyperplasia, Histiocytic | 2 | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | 2 | 1 2.0|
Renal, Hemorrhage | 3 2 1 | 4 2.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 1.0|
Hemorrhage | 2 1 | 4 1.5|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Hyperplasia, Plasma Cell | | 4 2.5|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 3 2 | 6 2.2|
Hyperplasia, Histiocytic | 2 2 | 4 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Fibrosis | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 3 | 3 2.7|
Pigmentation | 2 2 2 3 1 3 | 8 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 3| 3| 3| 3| 0| 3| 3| 1| 3| 2| 9| 3| 3| 3| 5| 3| 0| 6| 9| 2| 3| 3| |
| 3| 7| 4| 4| 4| 4| 5| 6| 5| 3| 4| 4| 5| 7| 4| 4| 4| 9| 4| 8| 1| 4| 1| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
325 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Atrophy | 2 3 2 2 2 3 2 3 3 4 | 17 2.5|
Hemorrhage | | 1 2.0|
Epithelial Cell, Hyperplasia | 2 2 2 | 9 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 2 2 1 4 4 1 3 4 1 4 1 | 25 2.2|
Hyperplasia | 2 1 3 4 2 4 2 1| 14 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 2 4 | 7 2.3|
Malformation | | 1 |
Femur, Hyperostosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 3 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 2.0|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | X | 1 |
Olfactory Epithelium, Atrophy | 1 | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 1 2 | 4 1.5|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 2 1 2 1 | 8 1.3|
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
Respiratory Epithelium, Inflammation,| | |
Chronic Active | 1 3 2 4 2 4 1 | 18 2.3|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 3| 3| 3| 3| 0| 3| 3| 1| 3| 2| 9| 3| 3| 3| 5| 3| 0| 6| 9| 2| 3| 3| |
| 3| 7| 4| 4| 4| 4| 5| 6| 5| 3| 4| 4| 5| 7| 4| 4| 4| 9| 4| 8| 1| 4| 1| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
325 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts | | 1 2.0|
Inflammation, Acute | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 26 1.0|
Nephropathy | 1 3 3 1 4 1 1 2 1 1 1| 15 1.5|
Renal Tubule, Degeneration, Hyaline | 1 | 1 1.0|
Renal Tubule, Pigmentation | 2 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 2| 3| 9| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 3| 9| 0| 3| 3| 6| 3| 3| 3|
| 0| 5| 5| 2| 4| 8| 3| 5| 4| 2| 4| 4| 4| 4| 9| 6| 4| 2| 8| 5| 5| 1| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
650 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A A + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | 3 3 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + A + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + A + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X X X |
Fibrosis | 2 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous | 2 1 1 1 1 1 |
Mixed Cell Focus | X X X X X |
Necrosis | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 3 4 2 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Acinus, Atrophy | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
Ulcer | 2 |
Epithelium, Hyperplasia | 3 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 4 2 1 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 2 1 |
Hemorrhage | |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 2| 3| 9| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 3| 9| 0| 3| 3| 6| 3| 3| 3|
| 0| 5| 5| 2| 4| 8| 3| 5| 4| 2| 4| 4| 4| 4| 9| 6| 4| 2| 8| 5| 5| 1| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
650 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cytoplasmic Alteration | 2 1 |
Vacuolization Cytoplasmic | 2 2 1 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 1 2 2 4 4 3 |
Pars Distalis, Pigmentation | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 3 |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | 2 2 1 4|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 4 |
Interstitial Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 4 |
Hyperplasia, Cystic | 2 |
Bilateral, Hydrometra | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
Atrophy | 1 |
Fibrosis | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Hemorrhage | |
Pancreatic, Hemorrhage | 3 |
Renal, Hemorrhage | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Plasma Cell | 2 |
Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 2| 3| 9| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 3| 9| 0| 3| 3| 6| 3| 3| 3|
| 0| 5| 5| 2| 4| 8| 3| 5| 4| 2| 4| 4| 4| 4| 9| 6| 4| 2| 8| 5| 5| 1| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
650 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
Hyperplasia, Histiocytic | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Necrosis | 2 |
Pigmentation | 2 2 2 1 2 |
Capsule, Cyst | |
Capsule, Fibrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 4 2 2 3 3 2|
Hemorrhage | |
Epithelial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 3 4 1 4 3 2 1 1 2 4 3 1 2|
Hyperplasia | 2 1 3 2 2 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Chronic Active | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Mediastinum, Necrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + A + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 2 1 2 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 2| 3| 9| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 3| 9| 0| 3| 3| 6| 3| 3| 3|
| 0| 5| 5| 2| 4| 8| 3| 5| 4| 2| 4| 4| 4| 4| 9| 6| 4| 2| 8| 5| 5| 1| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
650 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Inflammation,| |
Chronic Active | 4 2 4 4|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
External Ear, Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 |
Inflammation, Chronic Active | |
Mineralization | 1 1 2 1 2 1 1 1 1 1 1 2 1 1 1|
Nephropathy | 1 1 2 1 1 1 4 3 3 1 1 2 1 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 3| 4| 3| 6| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 4| 3| 3| 3| 1| 3| |
| 4| 3| 4| 9| 1| 8| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 9| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
650 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 7 1.6|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + A + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 2 | 7 1.9|
Basophilic Focus | X X X X X X X X X X X X X X X X| 32 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X | 4 |
Fibrosis | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 4 |
Inflammation, Granulomatous | 1 1 1 1 1 | 11 1.1|
Mixed Cell Focus | X| 6 |
Necrosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 10 |
Fat, Necrosis | 2 3 2 3 | 9 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Acinus, Atrophy | 1 1 1 | 5 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 3 2.0|
Ulcer | 4 3 4 | 4 3.3|
Epithelium, Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 1| 11 1.3|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 3| 4| 3| 6| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 4| 3| 3| 3| 1| 3| |
| 4| 3| 4| 9| 1| 8| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 9| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
650 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Atrium, Thrombosis | 3 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 2 1 1 2 1 2| 10 1.5|
Cytoplasmic Alteration | 1 1 | 4 1.3|
Vacuolization Cytoplasmic | 2 1 1 | 8 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 | 1 2.0|
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | 2 2 1 2 1 2 2| 13 2.2|
Pars Distalis, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 3 1 1 | 8 1.6|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 2 2.0|
Cyst | 2 1 | 6 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 3 3 1 4 | 8 3.0|
Interstitial Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 1 | 4 2.3|
Hyperplasia, Cystic | | 1 2.0|
Bilateral, Hydrometra | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 2 1.5|
Fibrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 3| 4| 3| 6| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 4| 3| 3| 3| 1| 3| |
| 4| 3| 4| 9| 1| 8| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 9| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
650 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Mediastinal, Hemorrhage | 3 | 1 3.0|
Pancreatic, Hemorrhage | | 1 3.0|
Renal, Hemorrhage | 4 | 1 4.0|
Renal, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 2 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 2 2 | 5 2.4|
Hyperplasia, Histiocytic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis | | 1 2.0|
Pigmentation | 2 2 3 2 2 | 10 2.0|
Capsule, Cyst | 1 | 1 1.0|
Capsule, Fibrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 2 2 2 2 | 14 2.4|
Hemorrhage | 2 2 3 | 3 2.3|
Epithelial Cell, Hyperplasia | 2 1| 4 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 1 4 3 2 4 1 2 4 3 1 1 3 | 27 2.4|
Hyperplasia | 2 2 2 2 2 1 3 4 2 3 3 | 19 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 1 1.0|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 9| 3| 4| 3| 6| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 4| 3| 3| 3| 1| 3| |
| 4| 3| 4| 9| 1| 8| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 9| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
650 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 2 1.0|
Inflammation, Chronic Active | 1 | 2 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 | 2 1.0|
Mediastinum, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 1 | 3 1.3|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 1| 12 1.2|
Respiratory Epithelium, Hyperplasia | 1 | 5 1.0|
Respiratory Epithelium, Inflammation,| | |
Chronic Active | 2 1 | 6 2.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 2 |
External Ear, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 3.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 30 1.1|
Nephropathy | 1 2 2 1 4 2 1 | 20 1.8|
Renal Tubule, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 6| 7| 3| 4| 5| 7| 6| 7| 5| 7| 6| 7| 6| 5| 5| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 8| 2| 3| 9| 1| 2| 6| 4| 8| 2| 2| 2| 2| 2| 8| 2| 9| 7| 5| 2| 5| 3| 0| 2| 2|
| 0| 6| 7| 4| 1| 9| 2| 5| 5| 9| 9| 9| 9| 9| 7| 9| 7| 9| 1| 9| 8| 2| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + A + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + + + + + + + + + + A A + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + M + + + + + + + A + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2|
Basophilic Focus | X X |
Clear Cell Focus | X X X|
Congestion | 1 4 |
Cyst | |
Deformity | |
Degeneration, Cystic | 2 2 2 2 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | X X X|
Vacuolization Cytoplasmic | 2 |
Bile Duct, Hyperplasia | 3 |
Centrilobular, Degeneration | |
Centrilobular, Vacuolization | |
Cytoplasmic | |
Kupffer Cell, Pigmentation | |
__________________________________________________________________________|
Mesentery | + + +|
Necrosis | 3 |
Pigmentation | |
Fat, Necrosis | 4 2|
__________________________________________________________________________|
Oral Mucosa | + |
Hyperplasia | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 2 1 1 2 2 |
Artery, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | 4 2 1 3 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 6| 7| 3| 4| 5| 7| 6| 7| 5| 7| 6| 7| 6| 5| 5| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 8| 2| 3| 9| 1| 2| 6| 4| 8| 2| 2| 2| 2| 2| 8| 2| 9| 7| 5| 2| 5| 3| 0| 2| 2|
| 0| 6| 7| 4| 1| 9| 2| 5| 5| 9| 9| 9| 9| 9| 7| 9| 7| 9| 1| 9| 8| 2| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Necrosis | 1 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 1 1 1 2 3 1 2 2 2 2 2 2 1 2|
Mineralization | |
Artery, Inflammation, Chronic Active | 3 |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 3 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + M + + +|
Pars Distalis, Angiectasis | 2 1 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 3 3 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
Necrosis | |
__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 2 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 6| 7| 3| 4| 5| 7| 6| 7| 5| 7| 6| 7| 6| 5| 5| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 8| 2| 3| 9| 1| 2| 6| 4| 8| 2| 2| 2| 2| 2| 8| 2| 9| 7| 5| 2| 5| 3| 0| 2| 2|
| 0| 6| 7| 4| 1| 9| 2| 5| 5| 9| 9| 9| 9| 9| 7| 9| 7| 9| 1| 9| 8| 2| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 1 3 1 |
Interstitial Cell, Hyperplasia | 2 2 2 1 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Hyperplasia | 4 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Hemorrhage | |
Iliac, Hemorrhage | 3 |
Mediastinal, Hemorrhage | 2 3 2 1 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 |
Mediastinal, Pigmentation | |
Pancreatic, Hemorrhage | |
Renal, Hemorrhage | 2 |
Renal, Hyperplasia, Plasma Cell | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 2 2 2 2|
Hyperplasia, Plasma Cell | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 |
Hemorrhage | 2 3 |
Hyperplasia, Lymphoid | 2 2 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | 4 4 3 |
Fibrosis | 3 3 4 2 2 |
Hematopoietic Cell Proliferation | 4 2 |
Necrosis | 2 3 |
Pigmentation | |
Capsule, Fibrosis | |
Capsule, Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +|
Atrophy | 2 2 2 3 3 3 3 2 2 2 3 4 2 2 2 2 2 2|
Hemorrhage | 2 |
Epithelial Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 6| 7| 3| 4| 5| 7| 6| 7| 5| 7| 6| 7| 6| 5| 5| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 8| 2| 3| 9| 1| 2| 6| 4| 8| 2| 2| 2| 2| 2| 8| 2| 9| 7| 5| 2| 5| 3| 0| 2| 2|
| 0| 6| 7| 4| 1| 9| 2| 5| 5| 9| 9| 9| 9| 9| 7| 9| 7| 9| 1| 9| 8| 2| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 2 |
Hyperplasia | 3 |
Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 2 |
Hyperkeratosis | |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Mineralization | 2 |
Meninges, Angiectasis | |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Alveolar Epithelium, Hyperplasia | 4 3 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasopharyngeal Duct, Inflammation, | |
Chronic Active | 4 |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Olfactory Epithelium, Foreign Body | |
Olfactory Epithelium, Hyperplasia | |
Olfactory Epithelium, Inflammation, | |
Chronic Active | 1 3 2 2 |
Olfactory Epithelium, Metaplasia | 3 |
Respiratory Epithelium, Foreign Body | |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 2 1 |
Respiratory Epithelium, Inflammation,| |
Chronic | 3 |
Respiratory Epithelium, Inflammation,| |
Chronic Active | 4 2 3 2 3 3 3 4 3 2 4|
Respiratory Epithelium, Metaplasia, | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 6| 7| 3| 4| 5| 7| 6| 7| 5| 7| 6| 7| 6| 5| 5| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 8| 2| 3| 9| 1| 2| 6| 4| 8| 2| 2| 2| 2| 2| 8| 2| 9| 7| 5| 2| 5| 3| 0| 2| 2|
| 0| 6| 7| 4| 1| 9| 2| 5| 5| 9| 9| 9| 9| 9| 7| 9| 7| 9| 1| 9| 8| 2| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Squamous | 2 |
Respiratory Epithelium, Thrombosis | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Hemorrhage | 2 |
Hydronephrosis | 1 |
Mineralization | |
Nephropathy | 2 4 2 1 3 2 2 1 1 1 1 3 2 3 2 1 1 3 1 2 1 3 4|
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 2| 2| 1| 2| 2| 2| 0| 9| 5| 7| 2| 1| 2| 2| 2| 2| 7| 0| 2| 9| 7| 2| 3| 9| 2| |
| 9| 9| 6| 9| 9| 9| 2| 9| 5| 3| 9| 4| 9| 9| 9| 9| 9| 9| 9| 3| 8| 9| 5| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + M + + A + + + +| 46 |
Parasite Metazoan | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + A + + + A + + + +| 45 |
Parasite Metazoan | 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + A + + + + A + + + A + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + A + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + A + + + + A + + A A + A + +| 39 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + A + + + + A A + A A + A + +| 39 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 3 2 | 5 2.0|
Basophilic Focus | X | 3 |
Clear Cell Focus | X X X X | 7 |
Congestion | | 2 2.5|
Cyst | 2 | 1 2.0|
Deformity | X | 1 |
Degeneration, Cystic | 1 1 1 2 1 2 1 2| 12 1.6|
Eosinophilic Focus | X X X | 4 |
Hepatodiaphragmatic Nodule | X X| 2 |
Inflammation, Chronic Active | | 1 1.0|
Mixed Cell Focus | X X X | 6 |
Vacuolization Cytoplasmic | 1 | 2 1.5|
Bile Duct, Hyperplasia | | 1 3.0|
Centrilobular, Degeneration | 3 | 1 3.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 2 | 1 2.0|
Kupffer Cell, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + +| 12 |
Necrosis | | 1 3.0|
Pigmentation | 3 | 1 3.0|
Fat, Necrosis | 3 3 4 4 3 3 4 | 9 3.3|
__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Acinus, Atrophy | 2 1 1 3 | 10 1.8|
Artery, Hyperplasia | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 2 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 2| 2| 1| 2| 2| 2| 0| 9| 5| 7| 2| 1| 2| 2| 2| 2| 7| 0| 2| 9| 7| 2| 3| 9| 2| |
| 9| 9| 6| 9| 9| 9| 2| 9| 5| 3| 9| 4| 9| 9| 9| 9| 9| 9| 9| 3| 8| 9| 5| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 2 2 4 4 4 2| 10 2.8|
Epithelium, Hyperplasia | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
Mineralization | 1 | 1 1.0|
Necrosis | 2 1 1 3 2 1 2 2 1 1 3 | 17 1.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + M + + + + + M + +| 48 |
Aorta, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 4 2 2 2 1 1 2 2 1 1 4 2 2 1 2 1| 35 1.7|
Mineralization | 2 3 | 2 2.5|
Artery, Inflammation, Chronic Active | | 1 3.0|
Atrium, Thrombosis | 4 3 | 3 3.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 3 2 | 10 2.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 2 | 3 1.7|
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 3 2 3 | 8 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
C-Cell, Hyperplasia | 1 1 3 | 4 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + + | 3 |
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Abdominal, Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 2| 2| 1| 2| 2| 2| 0| 9| 5| 7| 2| 1| 2| 2| 2| 2| 7| 0| 2| 9| 7| 2| 3| 9| 2| |
| 9| 9| 6| 9| 9| 9| 2| 9| 5| 3| 9| 4| 9| 9| 9| 9| 9| 9| 9| 3| 8| 9| 5| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 3 2.3|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 1 1 2 | 5 1.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
Inflammation, Chronic Active | 4 | 4 2.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 1 3| 8 2.4|
Interstitial Cell, Hyperplasia | 1 2 1 | 8 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + A + +| 47 |
Atrophy | 1 3 | 4 2.0|
Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 24 |
Hemorrhage | 3 | 1 3.0|
Iliac, Hemorrhage | | 1 3.0|
Mediastinal, Hemorrhage | 2 3 2 4 2 | 11 2.3|
Mediastinal, Hyperplasia, Lymphoid | 2 | 3 2.0|
Mediastinal, Pigmentation | 2 3 2 | 3 2.3|
Pancreatic, Hemorrhage | 3 | 1 3.0|
Renal, Hemorrhage | 2 3 | 3 2.3|
Renal, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Renal, Pigmentation | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 | 1 3.0|
Hemorrhage | 4 1 | 3 2.7|
Hyperplasia, Lymphoid | | 5 2.0|
Hyperplasia, Plasma Cell | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Ectasia | 3 | 3 2.3|
Hemorrhage | 4 3 | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 2| 2| 1| 2| 2| 2| 0| 9| 5| 7| 2| 1| 2| 2| 2| 2| 7| 0| 2| 9| 7| 2| 3| 9| 2| |
| 9| 9| 6| 9| 9| 9| 2| 9| 5| 3| 9| 4| 9| 9| 9| 9| 9| 9| 9| 3| 8| 9| 5| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 4 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Congestion | | 3 3.7|
Fibrosis | 4 1 2 2 3 | 10 2.6|
Hematopoietic Cell Proliferation | 3 | 3 3.0|
Necrosis | 2 | 3 2.3|
Pigmentation | 3 4 | 2 3.5|
Capsule, Fibrosis | 3 2 | 2 2.5|
Capsule, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 2 3 2 2 2 4 2 3 2 3 3 | 30 2.4|
Hemorrhage | 2 2 | 3 2.0|
Epithelial Cell, Hyperplasia | 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 1 2 1 2 1 2 | 8 1.9|
Hyperplasia | | 1 3.0|
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 2.0|
Hyperkeratosis | 4 2 | 2 3.0|
Inflammation, Chronic Active | 2 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Mineralization | | 1 2.0|
Meninges, Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 2| 2| 1| 2| 2| 2| 0| 9| 5| 7| 2| 1| 2| 2| 2| 2| 7| 0| 2| 9| 7| 2| 3| 9| 2| |
| 9| 9| 6| 9| 9| 9| 2| 9| 5| 3| 9| 4| 9| 9| 9| 9| 9| 9| 9| 3| 8| 9| 5| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 | 4 3.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasopharyngeal Duct, Inflammation, | | |
Chronic Active | | 1 4.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 | 1 1.0|
Olfactory Epithelium, Foreign Body | X | 1 |
Olfactory Epithelium, Hyperplasia | 3 | 1 3.0|
Olfactory Epithelium, Inflammation, | | |
Chronic Active | 1 4 2 2 3 2 | 10 2.2|
Olfactory Epithelium, Metaplasia | | 1 3.0|
Respiratory Epithelium, Foreign Body | X X X | 3 |
Respiratory Epithelium, Hyperplasia | 1 2 2 1 1 1 1 4 1 2 2 1 1 2 | 22 1.4|
Respiratory Epithelium, Inflammation,| | |
Chronic | | 1 3.0|
Respiratory Epithelium, Inflammation,| | |
Chronic Active | 3 2 3 4 1 4 1 2 4 2 3 | 22 2.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 4 | 2 3.0|
Respiratory Epithelium, Thrombosis | 3 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 | 3 2.3|
Hemorrhage | | 1 2.0|
Hydronephrosis | | 1 1.0|
Mineralization | 2 2 | 2 2.0|
Nephropathy | 4 3 1 3 3 3 1 2 2 2 4 3 3 2 2 4 2 2 1 2 1 3 4| 46 2.2|
Renal Tubule, Pigmentation | 3 3 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 6| 5| 5| 5| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 3| 8| 0| 1| 9| 9| 4| 2| 9| 9| 2| 2| 5| 2| 2| 2| 2| 2| 7| 2| 2| 0| 1| 2|
| 9| 0| 8| 7| 1| 2| 3| 4| 9| 7| 3| 1| 9| 5| 3| 9| 9| 9| 9| 5| 9| 9| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
150 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + A + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Parasite Metazoan | 3 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + A + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + A A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A A + + + + + + + + A + + A A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + A A + + + + + + + + A + + A A +|
Parasite Metazoan | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 3 |
Clear Cell Focus | X X X|
Deformity | X |
Degeneration, Cystic | 3 1 |
Eosinophilic Focus | X X X |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X|
Bile Duct, Hyperplasia | 2 1 |
Centrilobular, Congestion | 2 |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 3 |
Vein, Dilatation | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic Active | 2 |
Fat, Necrosis | 3 2 3 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + A A +|
Acinus, Atrophy | 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Chronic Active | 2 |
Ulcer | 4 4 4 3 4 |
Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hyperplasia, Lymphoid | 3 |
Mineralization | 3 |
Necrosis | 2 2 3 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 6| 5| 5| 5| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 3| 8| 0| 1| 9| 9| 4| 2| 9| 9| 2| 2| 5| 2| 2| 2| 2| 2| 7| 2| 2| 0| 1| 2|
| 9| 0| 8| 7| 1| 2| 3| 4| 9| 7| 3| 1| 9| 5| 3| 9| 9| 9| 9| 5| 9| 9| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
150 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 1 2 2 3 2 3 2 3 2 1 2 2 2 1 2 2 |
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + A +|
Cytoplasmic Alteration | 2 |
Hemorrhage | |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | 1 2 3 3 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + A A +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Intermedia, Cyst | |
Pars Nervosa, Hemorrhage | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Inflammation, Chronic Active | 1 1 1 1 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + M + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 3 4 2 3 |
Interstitial Cell, Hyperplasia | 3 2 3 3 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + A + + + + + + + + + + + A A +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 6| 5| 5| 5| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 3| 8| 0| 1| 9| 9| 4| 2| 9| 9| 2| 2| 5| 2| 2| 2| 2| 2| 7| 2| 2| 0| 1| 2|
| 9| 0| 8| 7| 1| 2| 3| 4| 9| 7| 3| 1| 9| 5| 3| 9| 9| 9| 9| 5| 9| 9| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
150 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 2 2 2 |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Hemorrhage | |
Iliac, Hemorrhage | |
Iliac, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Hemorrhage | 2 2 2 2 4|
Mediastinal, Hyperplasia, Lymphoid | 2 2 |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 4 |
Mediastinal, Pigmentation | 2 2 |
Pancreatic, Ectasia | |
Pancreatic, Hemorrhage | 3 |
Renal, Ectasia | 2 |
Renal, Hemorrhage | |
Renal, Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 2 3 3 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | 2 3 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 3 3 2 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Fibrosis | 2 3 2 2 2 2 3 2 2 2 |
Hematopoietic Cell Proliferation | 3 1 2 |
Necrosis | |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + M|
Atrophy | 3 3 2 3 2 3 2 |
Epithelial Cell, Hyperplasia | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + M + + + M + + + + + + + + + M +|
Dilatation | 2 1 1 3 1 3 4|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 6| 5| 5| 5| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 3| 8| 0| 1| 9| 9| 4| 2| 9| 9| 2| 2| 5| 2| 2| 2| 2| 2| 7| 2| 2| 0| 1| 2|
| 9| 0| 8| 7| 1| 2| 3| 4| 9| 7| 3| 1| 9| 5| 3| 9| 9| 9| 9| 5| 9| 9| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
150 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + A + + + + + + + + + + + + + + + + + A +|
Foreign Body | X X |
Olfactory Epithelium, Inflammation, | |
Chronic Active | 3 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 |
Respiratory Epithelium, Hyperplasia | 2 2 1 1 1 1 1 1 3 1 2 1 1 1|
Respiratory Epithelium, Inflammation,| |
Chronic Active | 2 3 2 3 2 1 3 4 4 4 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Hemorrhage | 3 |
Lens, Cataract | 3 |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +|
Fibrosis | 2 |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
Necrosis | 2 |
Nephropathy | 3 2 2 2 1 1 1 4 1 1 2 2 1 2 3 4 4 3 3 3 2 4|
Renal Tubule, Hyperplasia | 3 |
Renal Tubule, Pigmentation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 0| 5| 1| 3| 2| 4| 2| 2| 2| 2| 5| 2| 2| 1| 2| 2| 2| 5| 2| 2| 4| 2| 1| 0| 2| |
| 2| 5| 8| 6| 9| 3| 9| 9| 9| 9| 5| 9| 9| 6| 9| 8| 9| 7| 9| 9| 8| 9| 1| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
150 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + A +| 46 |
Parasite Metazoan | 1 2 3 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + A +| 47 |
Parasite Metazoan | 1 | 3 2.7|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + A +| 46 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + A + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + A + + + + + A +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + A + A + + + + + + +| 41 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 3 2 1 2 2 | 11 2.0|
Clear Cell Focus | X X X X X | 8 |
Deformity | X | 2 |
Degeneration, Cystic | 1 3 1 2 1 2 | 8 1.8|
Eosinophilic Focus | X X X X X X X | 10 |
Hemorrhage | 4 1 | 2 2.5|
Hepatodiaphragmatic Nodule | X X | 3 |
Mixed Cell Focus | X X X X X| 6 |
Bile Duct, Hyperplasia | | 2 1.5|
Centrilobular, Congestion | | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 2 3.0|
Vein, Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 11 |
Inflammation, Chronic Active | | 1 2.0|
Fat, Necrosis | 2 4 2 3 4 | 10 3.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + A + A + + + + + + +| 45 |
Acinus, Atrophy | 1 1 1 1 2 3 3| 9 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 | 2 2.0|
Ulcer | 2 3 3 2 4 | 10 3.3|
Epithelium, Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 0| 5| 1| 3| 2| 4| 2| 2| 2| 2| 5| 2| 2| 1| 2| 2| 2| 5| 2| 2| 4| 2| 1| 0| 2| |
| 2| 5| 8| 6| 9| 3| 9| 9| 9| 9| 5| 9| 9| 6| 9| 8| 9| 7| 9| 9| 8| 9| 1| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
150 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 3.0|
Necrosis | 1 2 2 1 2 2 3 1 2 | 14 1.9|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 2 2 2 3 2 1 1 1 3 1 2 2 2 1 2 1 2 2| 41 1.8|
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cytoplasmic Alteration | 1 | 2 1.5|
Hemorrhage | 2 | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 | 8 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + A + + + + + + +| 45 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Cyst | 2 1 1 | 3 1.3|
Pars Distalis, Hemorrhage | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 3 3 | 5 2.4|
Pars Intermedia, Cyst | 3 | 1 3.0|
Pars Nervosa, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 4 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 0| 5| 1| 3| 2| 4| 2| 2| 2| 2| 5| 2| 2| 1| 2| 2| 2| 5| 2| 2| 4| 2| 1| 0| 2| |
| 2| 5| 8| 6| 9| 3| 9| 9| 9| 9| 5| 9| 9| 6| 9| 8| 9| 7| 9| 9| 8| 9| 1| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
150 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 1.5|
Inflammation, Chronic Active | | 5 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 3 3 | 9 2.7|
Interstitial Cell, Hyperplasia | 2 1 2 1 1 | 11 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + A + A + + + + + + +| 45 |
Hyperplasia | 3 | 4 2.3|
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 23 |
Hemorrhage | 2 | 1 2.0|
Iliac, Hemorrhage | 2 | 1 2.0|
Iliac, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Hemorrhage | 1 2 3 1 3 4 | 11 2.4|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 4.0|
Mediastinal, Pigmentation | | 2 2.0|
Pancreatic, Ectasia | 2 | 1 2.0|
Pancreatic, Hemorrhage | 3 1 4 | 4 2.8|
Renal, Ectasia | 2 2 | 3 2.0|
Renal, Hemorrhage | 2 2 2 | 3 2.0|
Renal, Pigmentation | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 2 | 8 2.5|
Hemorrhage | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia, Plasma Cell | 2 2 | 4 2.3|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 1 2.0|
Hemorrhage | 4 | 4 3.0|
Hyperplasia, Lymphoid | 1 | 2 1.5|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 0| 5| 1| 3| 2| 4| 2| 2| 2| 2| 5| 2| 2| 1| 2| 2| 2| 5| 2| 2| 4| 2| 1| 0| 2| |
| 2| 5| 8| 6| 9| 3| 9| 9| 9| 9| 5| 9| 9| 6| 9| 8| 9| 7| 9| 9| 8| 9| 1| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
150 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Atrophy | | 1 2.0|
Fibrosis | 2 2 2 2 2 2 | 16 2.1|
Hematopoietic Cell Proliferation | 2 3 | 5 2.2|
Necrosis | 2 | 1 2.0|
Capsule, Fibrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | I + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | 2 3 3 2 2 3 2 3 2 2 3 3| 19 2.5|
Epithelial Cell, Hyperplasia | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 45 |
Dilatation | 3 1 4 1 1 2 | 13 2.1|
Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
Epidermis, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 |
Foreign Body | | 2 |
Olfactory Epithelium, Inflammation, | | |
Chronic Active | | 2 2.5|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 | 2 1.5|
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 | 20 1.3|
Respiratory Epithelium, Inflammation,| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 0| 5| 1| 3| 2| 4| 2| 2| 2| 2| 5| 2| 2| 1| 2| 2| 2| 5| 2| 2| 4| 2| 1| 0| 2| |
| 2| 5| 8| 6| 9| 3| 9| 9| 9| 9| 5| 9| 9| 6| 9| 8| 9| 7| 9| 9| 8| 9| 1| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
150 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Chronic Active | 2 2 4 1 | 15 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Hemorrhage | | 1 3.0|
Lens, Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
Necrosis | | 1 2.0|
Nephropathy | 3 1 1 3 1 3 4 3 2 1 4 2 2 3 1 3 1 3 3 2 2 3 1 2| 46 2.3|
Renal Tubule, Hyperplasia | | 1 3.0|
Renal Tubule, Pigmentation | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 6| 5| 7| 5|
DAY ON TEST | 2| 5| 2| 2| 9| 8| 2| 7| 3| 2| 2| 2| 5| 2| 5| 7| 2| 2| 2| 2| 8| 4| 7| 2| 6|
| 7| 9| 9| 9| 5| 2| 9| 3| 9| 9| 9| 9| 7| 8| 3| 2| 9| 9| 9| 9| 6| 1| 1| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
325 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + A + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + A + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + A + A + + + + A + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A + A + + + + A A + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 |
Clear Cell Focus | X |
Deformity | |
Degeneration, Cystic | 2 2 1 2 1 1 |
Eosinophilic Focus | X X X X |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic Active | |
Mixed Cell Focus | X X |
Necrosis | |
Vacuolization Cytoplasmic | 2 2 4 |
Bile Duct, Hyperplasia | |
Centrilobular, Degeneration | |
Centrilobular, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis | 3 2 2 4 4 2 4 |
Fat, Pigmentation | 2 |
__________________________________________________________________________|
Pancreas | + A + + + A + A + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Chronic Active | 2 |
Ulcer | 4 4 3 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Inflammation, Chronic Active | |
Necrosis | 2 2 2 3 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 6| 5| 7| 5|
DAY ON TEST | 2| 5| 2| 2| 9| 8| 2| 7| 3| 2| 2| 2| 5| 2| 5| 7| 2| 2| 2| 2| 8| 4| 7| 2| 6|
| 7| 9| 9| 9| 5| 2| 9| 3| 9| 9| 9| 9| 7| 8| 3| 2| 9| 9| 9| 9| 6| 1| 1| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
325 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 2 1 1 3 2 2 1 1 2 2 2 2 1 2 2|
Atrium, Thrombosis | 4 4 |
Ventricle, Pigmentation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cytoplasmic Alteration | 2 |
Degeneration, Cystic | 2 |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + A + + + A + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + A + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 3 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Chronic Active | 3 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 2 3 2 3|
Artery, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 6| 5| 7| 5|
DAY ON TEST | 2| 5| 2| 2| 9| 8| 2| 7| 3| 2| 2| 2| 5| 2| 5| 7| 2| 2| 2| 2| 8| 4| 7| 2| 6|
| 7| 9| 9| 9| 5| 2| 9| 3| 9| 9| 9| 9| 7| 8| 3| 2| 9| 9| 9| 9| 6| 1| 1| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
325 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Hyperplasia | 2 3 3 2 1 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + A + + + A + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Fibrosis | |
Hyperplasia | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Iliac, Hyperplasia, Lymphoid | |
Mediastinal, Congestion | |
Mediastinal, Ectasia | 4 |
Mediastinal, Hemorrhage | 2 2 2 2 3 3 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | 2 |
Pancreatic, Hemorrhage | |
Renal, Hemorrhage | 2 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hemorrhage | 2 2 2 |
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Plasma Cell | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hemorrhage | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | 3 3 2 2 2 4 4 3 1 |
Hematopoietic Cell Proliferation | |
Necrosis | 2 3 |
Pigmentation | 2 2 |
Capsule, Fibrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 3 2 3 2 2 3 2 3|
Hemorrhage | 2 2 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Dilatation | 4 1 2 1 4 |
Hyperplasia | 4 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 6| 5| 7| 5|
DAY ON TEST | 2| 5| 2| 2| 9| 8| 2| 7| 3| 2| 2| 2| 5| 2| 5| 7| 2| 2| 2| 2| 8| 4| 7| 2| 6|
| 7| 9| 9| 9| 5| 2| 9| 3| 9| 9| 9| 9| 7| 8| 3| 2| 9| 9| 9| 9| 6| 1| 1| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
325 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 4 |
Alveolar Epithelium, Hyperplasia | 4 |
Alveolus, Metaplasia, Squamous | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Inflammation, | |
Chronic Active | 2 3 2 4|
Respiratory Epithelium, Degeneration,| |
Hyaline | |
Respiratory Epithelium, Hyperplasia | 2 2 1 1 1 1 1 1 |
Respiratory Epithelium, Inflammation,| |
Chronic | |
Respiratory Epithelium, Inflammation,| |
Chronic Active | 3 4 2 2 4 2 2 2 2 2 4|
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Cyst | 3 4 |
Nephropathy | 1 1 4 4 2 3 2 3 3 2 1 4 4 1 3 2 3 3 1 3 4 3|
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 5| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 9| 2| 0| 0| 2| 2| 2| 2| 2| 0| 2| 2| 6| 2| 3| 9| 2| 4| 2| 2| 1| 1| |
| 9| 8| 9| 0| 9| 6| 3| 9| 9| 9| 9| 9| 8| 0| 9| 7| 9| 3| 2| 9| 8| 9| 9| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
325 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
Hemorrhage | | 1 2.0|
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + A + + + + + + + + + A +| 46 |
Parasite Metazoan | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + + A + + + + + + + + + A +| 45 |
Inflammation, Chronic Active | 2| 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + + A + + + + + + + + + A +| 41 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + + A + + + + + + + + + A +| 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 4 2 2 3| 7 2.9|
Clear Cell Focus | X X X X X X | 7 |
Deformity | X | 1 |
Degeneration, Cystic | 1 2 2 3 1 2 | 12 1.7|
Eosinophilic Focus | X X X X X X | 10 |
Hepatodiaphragmatic Nodule | X X X | 5 |
Inflammation, Chronic Active | 1 | 1 1.0|
Mixed Cell Focus | | 2 |
Necrosis | 3 | 1 3.0|
Vacuolization Cytoplasmic | 3 | 4 2.8|
Bile Duct, Hyperplasia | 2 2 2 | 3 2.0|
Centrilobular, Degeneration | 2 | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 10 |
Fat, Necrosis | 4 4 | 9 3.2|
Fat, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +| 46 |
Acinus, Atrophy | 1 1 2 2 2 1 1 1 2 | 13 1.4|
Acinus, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Diverticulum | 2 | 1 2.0|
Inflammation, Chronic Active | 3 | 2 2.5|
Ulcer | 4 2 4 3 2| 8 3.3|
Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 5| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 9| 2| 0| 0| 2| 2| 2| 2| 2| 0| 2| 2| 6| 2| 3| 9| 2| 4| 2| 2| 1| 1| |
| 9| 8| 9| 0| 9| 6| 3| 9| 9| 9| 9| 9| 8| 0| 9| 7| 9| 3| 2| 9| 8| 9| 9| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
325 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis | 2 2 3 2 1 2 2 | 13 2.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 3 2 1 1 2 2 2 2 3 1 2 3 1 1 2 2 1 1 3 2| 42 1.7|
Atrium, Thrombosis | 3 2 2 2 | 6 2.8|
Ventricle, Pigmentation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Cytoplasmic Alteration | 1 | 2 1.5|
Degeneration, Cystic | | 1 2.0|
Hyperplasia | | 1 1.0|
Vacuolization Cytoplasmic | 4 2 | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 3 2 1 | 8 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | | 3 3.3|
Pars Distalis, Cyst | 3 1 | 2 2.0|
Pars Distalis, Hyperplasia | 3 2 1 | 5 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 3 2 2 | 5 2.4|
Follicular Cell, Hyperplasia | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 5| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 9| 2| 0| 0| 2| 2| 2| 2| 2| 0| 2| 2| 6| 2| 3| 9| 2| 4| 2| 2| 1| 1| |
| 9| 8| 9| 0| 9| 6| 3| 9| 9| 9| 9| 9| 8| 0| 9| 7| 9| 3| 2| 9| 8| 9| 9| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
325 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 2 1| 3 1.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
Inflammation, Chronic Active | 2 1 2 2 | 7 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 4 3 2| 12 2.8|
Artery, Inflammation, Chronic Active | 2 | 2 2.5|
Interstitial Cell, Hyperplasia | 2 3 1| 10 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
Atrophy | | 1 3.0|
Fibrosis | 1 3 | 2 2.0|
Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 23 |
Iliac, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Congestion | 1 | 1 1.0|
Mediastinal, Ectasia | | 1 4.0|
Mediastinal, Hemorrhage | 2 3| 8 2.4|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
Mediastinal, Pigmentation | | 1 2.0|
Pancreatic, Hemorrhage | 3 2| 2 2.5|
Renal, Hemorrhage | | 1 2.0|
Renal, Pigmentation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 2 2.5|
Hemorrhage | | 3 2.0|
Hyperplasia, Lymphoid | 2 2 | 3 1.7|
Hyperplasia, Plasma Cell | 1 2 2 2 | 5 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 2 2.5|
Hemorrhage | 2 3| 4 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 2 2.5|
Fibrosis | 2 2 2 2 2 2 2 3 2 3| 19 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 5| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 9| 2| 0| 0| 2| 2| 2| 2| 2| 0| 2| 2| 6| 2| 3| 9| 2| 4| 2| 2| 1| 1| |
| 9| 8| 9| 0| 9| 6| 3| 9| 9| 9| 9| 9| 8| 0| 9| 7| 9| 3| 2| 9| 8| 9| 9| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
325 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 3 2 | 2 2.5|
Necrosis | | 2 2.5|
Pigmentation | | 2 2.0|
Capsule, Fibrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + I + + + + + + + + + +| 48 |
Atrophy | 2 2 3 2 2 3 2 | 18 2.6|
Hemorrhage | 3 | 3 2.3|
Epithelial Cell, Hyperplasia | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Dilatation | 3 4 1 1 | 9 2.3|
Hyperplasia | 4 2 2 | 5 2.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic Active | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 4 1 | 3 3.0|
Alveolar Epithelium, Hyperplasia | 4 2 3 2 3 | 6 3.0|
Alveolus, Metaplasia, Squamous | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Olfactory Epithelium, Inflammation, | | |
Chronic Active | 2 2 | 6 2.5|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 1 1.0|
Respiratory Epithelium, Hyperplasia | 1 2 1 1 1 1 1 1 | 16 1.2|
Respiratory Epithelium, Inflammation,| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 5| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 9| 2| 0| 0| 2| 2| 2| 2| 2| 0| 2| 2| 6| 2| 3| 9| 2| 4| 2| 2| 1| 1| |
| 9| 8| 9| 0| 9| 6| 3| 9| 9| 9| 9| 9| 8| 0| 9| 7| 9| 3| 2| 9| 8| 9| 9| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
325 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Chronic | 2 | 1 2.0|
Respiratory Epithelium, Inflammation,| | |
Chronic Active | 3 4 3 2 3 3 4 2 1 3 4 | 22 2.8|
Respiratory Epithelium, Inflammation | 2| 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 4.0|
Cyst | | 2 3.5|
Nephropathy | 4 1 3 1 4 3 2 4 4 4 3 4 1 1 3 2 2 1 4 3 3 2 3 3| 46 2.7|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
Renal Tubule, Pigmentation | 2 4 | 4 2.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 8| 2| 2| 2| 4| 2| 8| 6| 9| 2| 2| 2| 2| 2| 9| 2| 2| 2| 0| 2| 0| 8| 2| 4| 2|
| 2| 9| 9| 9| 8| 9| 6| 4| 0| 9| 9| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 2| 8| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
650 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + A + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + A + + + A + + A A + +|
Necrosis | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + A + + + + + + + A + +|
Fibrosis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 3 2 |
Clear Cell Focus | X X |
Degeneration, Cystic | 2 2 2 1 1 2 |
Eosinophilic Focus | X |
Mixed Cell Focus | X X|
Necrosis | 1 |
Vacuolization Cytoplasmic | |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Accessory Spleen | X |
Fat, Necrosis | 3 2 2 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + + A + + + + + +|
Acinus, Atrophy | 3 1 1 1 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Ulcer | 4 4 4 4 4 3 3 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Necrosis | 2 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 2 2 3 2 1 2 1 1 1 3 |
Fibrosis | 2 |
Mineralization | 2 |
Atrium, Thrombosis | 2 2 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 8| 2| 2| 2| 4| 2| 8| 6| 9| 2| 2| 2| 2| 2| 9| 2| 2| 2| 0| 2| 0| 8| 2| 4| 2|
| 2| 9| 9| 9| 8| 9| 6| 4| 0| 9| 9| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 2| 8| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
650 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | |
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + A + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 3 2 2 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 2 2 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Inflammation, Chronic Active | 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 1 2 |
Artery, Inflammation, Chronic Active | 2 |
Interstitial Cell, Hyperplasia | 4 3 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Hemorrhage | |
Mediastinal, Hemorrhage | 3 3 3 2 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 8| 2| 2| 2| 4| 2| 8| 6| 9| 2| 2| 2| 2| 2| 9| 2| 2| 2| 0| 2| 0| 8| 2| 4| 2|
| 2| 9| 9| 9| 8| 9| 6| 4| 0| 9| 9| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 2| 8| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
650 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Hemorrhage | 3 2 |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hemorrhage | 2 |
Renal, Hyperplasia, Lymphoid | 1|
Renal, Pigmentation | 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 1 2 2 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | 1 2 3 3 3 |
Hematopoietic Cell Proliferation | 2 3 |
Necrosis | |
Pigmentation | 2|
Capsule, Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Atrophy | 1 1 2 3 2 3 2 2 2 1 2 3 2 3 |
Hemorrhage | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 1|
Hyperplasia | 3 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Ulcer | 4 |
Hair Follicle, Atrophy | 3 |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Foreign Body | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 8| 2| 2| 2| 4| 2| 8| 6| 9| 2| 2| 2| 2| 2| 9| 2| 2| 2| 0| 2| 0| 8| 2| 4| 2|
| 2| 9| 9| 9| 8| 9| 6| 4| 0| 9| 9| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 2| 8| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
650 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Olfactory Epithelium, Foreign Body | X |
Olfactory Epithelium, Inflammation, | |
Chronic Active | 1 2 3 |
Respiratory Epithelium, Hyperplasia | 4 4 1 2 2 1 1 1 2 1 2|
Respiratory Epithelium, Inflammation,| |
Chronic | 2 |
Respiratory Epithelium, Inflammation,| |
Chronic Active | 4 4 2 3 2 4 2 2 4 4 1 4 |
Respiratory Epithelium, Metaplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
Respiratory Epithelium, Thrombosis | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | 2 |
Mineralization | 3 |
Nephropathy | 3 3 2 4 3 3 2 2 3 3 1 3 4 1 2 1 3 4 1 2 1 3 2 3 4|
Renal Tubule, Pigmentation | 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 6| 5| 7| 7| 5| 7| 6| 6| 6| 5| 7| 5| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 7| 0| 2| 7| 0| 6| 3| 2| 1| 2| 6| 2| 8| 6| 7| 9| 2| 8| |
| 9| 9| 9| 1| 9| 9| 9| 2| 9| 9| 6| 5| 9| 0| 0| 4| 9| 9| 9| 3| 3| 6| 7| 9| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
650 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Parasite Metazoan | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + A + + + +| 47 |
Parasite Metazoan | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 44 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + A + + + + + + A A + + + A| 42 |
Fibrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + A + + + + + + + A + + + A| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 1 3 2 | 9 1.9|
Clear Cell Focus | X | 3 |
Degeneration, Cystic | 1 1 2 2 2 3 | 12 1.8|
Eosinophilic Focus | X X | 3 |
Mixed Cell Focus | X X X | 5 |
Necrosis | 2 | 2 1.5|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 14 |
Accessory Spleen | | 1 |
Fat, Necrosis | 3 2 4 4 3 3 | 12 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Atrophy | 1 3 2 1 2 1 1| 12 1.5|
Acinus, Hyperplasia | 4 4 2 | 3 3.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Hemorrhage | 2 | 1 2.0|
Ulcer | 4 4 4 4 4 | 13 3.7|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Necrosis | 2 2 2 3 2 1 2 1 2 | 17 1.9|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 6| 5| 7| 7| 5| 7| 6| 6| 6| 5| 7| 5| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 7| 0| 2| 7| 0| 6| 3| 2| 1| 2| 6| 2| 8| 6| 7| 9| 2| 8| |
| 9| 9| 9| 1| 9| 9| 9| 2| 9| 9| 6| 5| 9| 0| 0| 4| 9| 9| 9| 3| 3| 6| 7| 9| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
650 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 2 1 2 2 1 2 3 1 1 1 2 1 1 2 2 3 3 2| 33 1.7|
Fibrosis | | 1 2.0|
Mineralization | | 1 2.0|
Atrium, Thrombosis | 4 | 4 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hemorrhage | 4 | 1 4.0|
Hyperplasia | 2 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | | 5 2.4|
Pars Distalis, Cyst | 2 | 2 1.5|
Pars Distalis, Hyperplasia | 4 2 1 | 7 2.1|
Pars Intermedia, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 4 | 4 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 3 2 | 3 2.3|
Fibrosis | 2 | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 1.5|
Inflammation, Chronic Active | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 4 4 | 8 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 6| 5| 7| 7| 5| 7| 6| 6| 6| 5| 7| 5| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 7| 0| 2| 7| 0| 6| 3| 2| 1| 2| 6| 2| 8| 6| 7| 9| 2| 8| |
| 9| 9| 9| 1| 9| 9| 9| 2| 9| 9| 6| 5| 9| 0| 0| 4| 9| 9| 9| 3| 3| 6| 7| 9| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
650 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Artery, Inflammation, Chronic Active | 2 | 2 2.0|
Interstitial Cell, Hyperplasia | 3 1 | 8 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 2 | 3 2.7|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + +| 24 |
Hemorrhage | 3 | 1 3.0|
Mediastinal, Hemorrhage | 2 2 1 2 2 2 2| 11 2.2|
Pancreatic, Hemorrhage | 1 1 4 | 5 2.2|
Pancreatic, Hyperplasia, Lymphoid | 1| 1 1.0|
Renal, Hemorrhage | 2 2 2 2 1 2 1 | 8 1.8|
Renal, Hyperplasia, Lymphoid | | 1 1.0|
Renal, Pigmentation | 1 3 2 2 2 2| 7 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 3 | 3 2.3|
Hemorrhage | 1 | 2 2.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
Hyperplasia, Plasma Cell | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 1 2.0|
Hemorrhage | 2 3 | 6 2.0|
Hyperplasia, Lymphoid | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 | 1 1.0|
Fibrosis | 2 3 3 2 2 2 2 3 2 | 14 2.4|
Hematopoietic Cell Proliferation | | 2 2.5|
Necrosis | 2 | 1 2.0|
Pigmentation | 3 | 2 2.5|
Capsule, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + M| 47 |
Atrophy | 2 2 2 3 2 2 3 3 3 3 3 2 3 | 27 2.3|
Hemorrhage | 2 2 | 2 2.0|
Epithelial Cell, Hyperplasia | 2 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + M + + + + + M + + + + +| 47 |
Dilatation | 2 3 2 | 6 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 6| 5| 7| 7| 5| 7| 6| 6| 6| 5| 7| 5| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 7| 0| 2| 7| 0| 6| 3| 2| 1| 2| 6| 2| 8| 6| 7| 9| 2| 8| |
| 9| 9| 9| 1| 9| 9| 9| 2| 9| 9| 6| 5| 9| 0| 0| 4| 9| 9| 9| 3| 3| 6| 7| 9| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
650 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 1 3 2 2 | 6 2.3|
Inflammation, Chronic Active | 1 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 | 1 2.0|
Ulcer | 4 | 2 4.0|
Hair Follicle, Atrophy | | 1 3.0|
Subcutaneous Tissue, Fibrosis | 2 | 1 2.0|
Subcutaneous Tissue, Foreign Body | X | 1 |
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 2 | 4 2.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 1 | 4 1.5|
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 | 2 1.0|
Olfactory Epithelium, Foreign Body | | 1 |
Olfactory Epithelium, Inflammation, | | |
Chronic Active | 3 4 | 5 2.6|
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 2 2| 28 1.5|
Respiratory Epithelium, Inflammation,| | |
Chronic | | 1 2.0|
Respiratory Epithelium, Inflammation,| | |
Chronic Active | 2 1 3 2 4 2 4 3 3 1 1 3 4 3 4 | 27 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05160-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 08:44:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 6| 5| 7| 7| 5| 7| 6| 6| 6| 5| 7| 5| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 7| 0| 2| 7| 0| 6| 3| 2| 1| 2| 6| 2| 8| 6| 7| 9| 2| 8| |
| 9| 9| 9| 1| 9| 9| 9| 2| 9| 9| 6| 5| 9| 0| 0| 4| 9| 9| 9| 3| 3| 6| 7| 9| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
650 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Metaplasia | 3 | 1 3.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
Respiratory Epithelium, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Atrophy | 4 | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Cyst | 1 4 | 3 2.3|
Mineralization | | 1 3.0|
Nephropathy | 4 3 2 2 4 3 2 2 2 4 4 2 3 2 1 4 4 2 3 1 2 2 3 2| 49 2.6|
Renal Tubule, Pigmentation | 2 | 3 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
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