TDMS Study 05160-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research 1-CHLORO-2-PROPANOL DATE: 07/30/97
EXPERIMENT: 05160 TEST: 05 TIME: 08:48:14
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-05300 ROUTE: DOSED WATER NTP C#: 61983C
PATHOLOGIST: STEDHAM, M. CAS: 127-00-4
------------------------------------------------------------------------------------------------------------------------------------
2 YEAR CHRONIC
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research 1-CHLORO-2-PROPANOL DATE: 07/30/97
EXPERIMENT: 05160 TEST: 05 TIME: 08:48:14
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-05300 ROUTE: DOSED WATER NTP C#: 61983C
PATHOLOGIST: STEDHAM, M. CAS: 127-00-4
1-CHLORO-2-PROPANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 362 445 494 502 529 532 551 578 579 579 |
| 580 585 599 611 616 629 635 637 655 658 |
| 673 687 693 693 697 703 709 714 726 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 150 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 388 502 544 548 555 555 592 593 609 611 |
| 613 630 636 643 655 657 675 693 697 706 |
| 707 711 716 718 721 723 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 325 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 408 457 533 559 564 571 572 573 582 592 |
| 603 606 627 639 641 648 653 667 668 686 |
| 690 695 710 714 720 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
1-CHLORO-2-PROPANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 650 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 502 520 520 564 569 569 582 585 597 605 |
| 630 648 648 663 672 676 676 682 683 686 |
| 690 697 707 709 714 721 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
1-CHLORO-2-PROPANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 98.0 98.0 96.0 88.0 74.0 60.0 40.0 |
| | |
| | |
|150 PPM | 100.0 100.0 100.0 100.0 98.0 98.0 94.0 84.0 68.0 46.0 |
| | |
| | |
|325 PPM | 100.0 100.0 100.0 100.0 98.0 96.0 94.0 78.0 66.0 48.0 |
| | |
| | |
|650 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 80.0 72.0 46.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 150 PPM 325 PPM 650 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 40.0% 46.0% 48.0% 46.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.564N P=0.476N P=0.507N P=0.514N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 612.6 634.3 619.5 638.6 |
|NATURAL DEATHS (C) | (16.2) (15.8) (15.5) (13.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 659.1 677.9 672.0 680.2 |
|(STANDARD ERROR) | (12.6) (10.8) (11.2) ( 9.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1-CHLORO-2-PROPANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 519 541 582 597 609 629 635 641 646 653 |
| 659 670 672 672 680 698 701 709 712 719 |
| 720 722 727 729 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 150 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 217 484 627 636 676 677 678 678 682 691 |
| 699 708 708 712 712 716 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 325 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 506 525 528 571 597 608 613 655 659 661 |
| 663 668 694 697 708 714 717 718 721 733 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
1-CHLORO-2-PROPANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 650 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 449 489 561 562 592 634 639 649 656 668 |
| 691 693 698 700 708 714 722 731 733 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
1-CHLORO-2-PROPANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 92.0 78.0 50.0 |
| | |
| | |
|150 PPM | 100.0 100.0 98.0 98.0 98.0 96.0 96.0 96.0 92.0 66.0 |
| | |
| | |
|325 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 90.0 78.0 60.0 |
| | |
| | |
|650 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 82.0 62.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 150 PPM 325 PPM 650 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 50.0% 66.0% 60.0% 62.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.513N P=0.137N P=0.474N P=0.334N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 662.8 648.8 647.8 646.8 |
|NATURAL DEATHS (C) | (11.7) (30.2) (16.0) (18.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 698.4 705.0 699.5 700.9 |
|(STANDARD ERROR) | ( 7.7) (11.6) ( 8.7) ( 9.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1-CHLORO-2-PROPANOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
150 PPM = 2
325 PPM = 3
650 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3 4
| 1 2 3 1 3 2 4
| 1 3 11 4 32234
| 1 1 2234
P 90 + 33
E | 1 12 4 4 2
R | 1 313 242
C | 3 3422
E 80 + 3 3 4
N | 11 2 2 4
T | 1 131 2224 4
| 2 2 44
S 70 + 1 1 33 44
U | 11 32 2
R | 1 1 32422
V | 3 3 22
I 60 + 1 133
V | 1 1322
A | 3422
L | 11 33
50 + 11422
| 1143 3
| 1 1 2
|
40 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 39 obs hidden.
1-CHLORO-2-PROPANOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
150 PPM = 2
325 PPM = 3
650 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 2 4 3 1
|
| 2 4 2 3 1 1
| 2 33 1 4 1 2
95 +
| 3 3 1 1 22
| 43 411 2 2
|
90 + 431 14
|
| 33 114
| 3 1143
P 85 +
E | 113 3 22
R | 11 4 22
C |
E 80 + 1 14 22
N |
T | 11 2 2
| 3 43
S 75 +
U |
R | 1 1 3 3
V |
I 70 + 1 1 22
V |
A | 11322
L | 11 2 2
65 +
|
| 11 3
|
60 + 3
|
| 11
|
55 +
| 1 1
|
|
50 + 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 26 obs hidden.