TDMS Study 05160-06 Pathology Tables
NTP Experiment-Test: 05160-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 09:11:09
2 YEAR CHRONIC
Facility: TSI Mason Research
Chemical CAS #: 127-00-4
Lock Date: 01/24/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05160-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 09:11:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 250 PPM 500 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 7 11 10 11
Moribund Sacrifice 8 7 3 5
Accidently Killed 3 1 2
Survivors
Terminal Sacrifice 32 32 36 32
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (42) (44) (45) (40)
Inflammation, Acute 1 (2%)
Necrosis 1 (3%)
Intestine Large, Cecum (44) (46) (48) (49)
Lymphoid Tissue, Hyperplasia 1 (2%)
Serosa, Inflammation, Chronic Active 1 (2%)
Intestine Small, Jejunum (46) (45) (47) (46)
Hyperplasia, Lymphoid 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Peyer's Patch, Inflammation, Acute 1 (2%)
Serosa, Inflammation, Chronic Active 1 (2%)
Intestine Small, Ileum (46) (44) (45) (45)
Serosa, Inflammation, Chronic Active 1 (2%)
Liver (50) (50) (50) (50)
Amyloid Deposition 1 (2%)
Angiectasis 1 (2%) 1 (2%)
Clear Cell Focus 2 (4%) 3 (6%) 2 (4%) 2 (4%)
Cyst 1 (2%) 1 (2%)
Eosinophilic Focus 29 (58%) 24 (48%) 29 (58%) 31 (62%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Leukocytosis 1 (2%) 1 (2%)
Mixed Cell Focus 2 (4%) 1 (2%)
Necrosis 1 (2%) 3 (6%) 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Hepatocyte, Portal, Vacuolization Cytoplasmic 1 (2%)
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 1 (2%)
Serosa, Inflammation, Chronic Active 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05160-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 09:11:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 250 PPM 500 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (20) (19) (16) (12)
Inflammation, Chronic Active 1 (6%)
Fat, Necrosis 19 (95%) 17 (89%) 14 (88%) 11 (92%)
Pancreas (50) (50) (50) (50)
Acinus, Atrophy 1 (2%) 1 (2%) 3 (6%)
Acinus, Hyperplasia 1 (2%) 1 (2%)
Duct, Cyst 1 (2%) 2 (4%)
Serosa, Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Hyperplasia, Squamous 3 (6%) 2 (4%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%) 2 (4%) 3 (6%)
Stomach, Glandular (50) (50) (48) (50)
Erosion 5 (10%) 2 (4%) 2 (4%) 2 (4%)
Mineralization 1 (2%)
Glands, Hyperplasia 1 (2%)
Serosa, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Angiectasis 1 (2%)
Cardiomyopathy 5 (10%) 2 (4%) 2 (4%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%) 2 (4%)
Atrium, Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Capsule, Hyperplasia 48 (96%) 50 (100%) 49 (98%) 48 (96%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 2 (4%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 28 (56%) 30 (60%) 30 (60%) 31 (62%)
Hypertrophy 1 (2%)
Pituitary Gland (49) (49) (47) (46)
Hemorrhage 1 (2%)
Pars Distalis, Angiectasis 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Pars Distalis, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05160-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 09:11:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 250 PPM 500 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 5 (10%) 3 (6%) 8 (17%) 10 (22%)
Pars Intermedia, Hemorrhage 1 (2%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 1 (2%)
Follicular Cell, Hyperplasia 13 (26%) 6 (12%) 15 (30%) 13 (26%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (49) (48) (49)
Cyst 1 (2%) 1 (2%)
Pigmentation 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Ovary (50) (49) (50) (50)
Angiectasis 2 (4%) 2 (4%)
Cyst 11 (22%) 9 (18%) 9 (18%) 11 (22%)
Hemorrhage 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Oviduct (1)
Cyst 1 (100%)
Uterus (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%) 3 (6%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Cystic 41 (82%) 46 (92%) 43 (86%) 44 (88%)
Inflammation, Acute 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Vagina (1)
Fibrosis 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Angiectasis 1 (2%)
Depletion Cellular 2 (4%)
Myelofibrosis 1 (2%)
Lymph Node (8) (12) (15) (9)
Iliac, Angiectasis 2 (13%)
Iliac, Hemorrhage 1 (11%)
Iliac, Hyperplasia, Lymphoid 2 (25%) 2 (17%) 2 (13%)
Iliac, Infiltration Cellular, Plasma Cell 1 (13%) 1 (8%) 1 (7%)
Mediastinal, Angiectasis 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05160-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 09:11:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 250 PPM 500 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Hemorrhage 1 (13%)
Mediastinal, Inflammation, Acute 1 (13%)
Mediastinal, Pigmentation 1 (11%)
Renal, Angiectasis 1 (8%)
Renal, Ectasia 1 (8%)
Renal, Hemorrhage 1 (7%)
Renal, Hyperplasia, Lymphoid 4 (27%)
Renal, Infiltration Cellular, Plasma Cell 1 (7%)
Lymph Node, Mandibular (50) (49) (49) (50)
Angiectasis 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Lymph Node, Mesenteric (49) (48) (47) (49)
Angiectasis 1 (2%) 2 (4%) 3 (6%) 1 (2%)
Ectasia 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Granulomatous 1 (2%)
Spleen (49) (50) (50) (50)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 13 (27%) 9 (18%) 16 (32%) 11 (22%)
Hyperplasia, Lymphoid 3 (6%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Pigmentation 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 8 (16%) 6 (12%) 5 (10%) 4 (8%)
Hyperplasia 2 (4%)
Skeletal Muscle (1) (2)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05160-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 09:11:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 250 PPM 500 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Demyelination 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Thalamus, Mineralization 22 (44%) 27 (55%) 22 (44%) 22 (44%)
Peripheral Nerve (2)
Demyelination 1 (50%)
Spinal Cord (2) (1)
Cyst Epithelial Inclusion 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 4 (8%) 3 (6%) 6 (12%) 3 (6%)
Infiltration Cellular, Lymphocyte 1 (2%)
Infiltration Cellular, Histiocyte 4 (8%) 2 (4%) 2 (4%) 4 (8%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Thrombosis 1 (2%) 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%)
Nose (50) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
External Ear, Inflammation, Chronic 1 (100%)
Eye (3)
Atrophy 1 (33%)
Inflammation, Acute 1 (33%)
Cornea, Inflammation, Acute 1 (33%)
Cornea, Necrosis 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Hydronephrosis 1 (2%) 3 (6%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Metaplasia, Osseous 2 (4%) 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05160-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 09:11:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 250 PPM 500 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Nephropathy, Acute 1 (2%)
Nephropathy, Chronic 16 (32%) 6 (12%) 9 (18%) 11 (22%)
Pigmentation 1 (2%)
Renal Tubule, Accumulation, Hyaline Droplet 3 (6%) 3 (6%) 1 (2%)
Renal Tubule, Dilatation 1 (2%)
Urinary Bladder (48) (49) (48) (49)
Inflammation, Acute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05160-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 09:11:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 250 PPM 500 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 8 7 4
Natural Death 2 6 9 4
Accidently Killed 5 3
Survivors
Terminal Sacrifice 40 44 29 39
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (49) (49)
Serosa, Inflammation, Chronic 1 (2%)
Intestine Large, Cecum (49) (50) (48) (47)
Serosa, Inflammation, Chronic 1 (2%)
Intestine Small, Jejunum (49) (49) (44) (47)
Diverticulum 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Clear Cell Focus 2 (4%) 11 (22%) 6 (12%) 3 (6%)
Eosinophilic Focus 27 (54%) 34 (68%) 33 (66%) 29 (58%)
Erythrophagocytosis 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%)
Mixed Cell Focus 2 (4%) 5 (10%) 1 (2%) 3 (6%)
Necrosis 6 (12%) 3 (6%) 1 (2%) 3 (6%)
Vacuolization Cytoplasmic 1 (2%) 2 (4%)
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 1 (2%)
Mesentery (4) (2) (6) (8)
Fat, Necrosis 4 (100%) 2 (100%) 6 (100%) 8 (100%)
Pancreas (50) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Acinus, Atrophy 3 (6%) 1 (2%) 2 (4%) 2 (4%)
Duct, Cyst 2 (4%)
Duct, Hemorrhage 1 (2%)
Duct, Inflammation, Chronic 1 (2%)
Salivary Glands (50) (50) (50) (50)
Metaplasia, Squamous 1 (2%)
Stomach, Forestomach (49) (50) (49) (50)
Angiectasis 1 (2%)
Hyperplasia, Squamous 4 (8%) 3 (6%) 2 (4%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05160-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 09:11:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 250 PPM 500 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Serosa, Inflammation, Acute 1 (2%)
Stomach, Glandular (49) (50) (50) (49)
Cyst 1 (2%) 1 (2%)
Erosion 3 (6%) 1 (2%) 1 (2%) 2 (4%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Ulcer 1 (2%)
Glands, Hyperplasia 1 (2%)
Tooth (4) (3) (4) (7)
Degeneration 4 (100%) 3 (100%) 4 (100%) 7 (100%)
Inflammation, Chronic Active 1 (25%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 6 (12%) 2 (4%) 2 (4%) 2 (4%)
Mineralization 2 (4%)
Atrium, Thrombosis 1 (2%)
Valve, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hemorrhage 1 (2%)
Hyperplasia 2 (4%)
Hypertrophy, Focal 18 (36%) 25 (50%) 21 (42%) 17 (34%)
Capsule, Hyperplasia 39 (78%) 42 (84%) 38 (76%) 38 (76%)
Adrenal Medulla (50) (50) (50) (50)
Hemorrhage 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 48 (96%) 47 (94%) 45 (90%) 47 (94%)
Pituitary Gland (50) (49) (49) (47)
Pars Distalis, Cyst 2 (4%) 3 (6%) 2 (4%)
Pars Distalis, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Cyst 1 (2%) 3 (6%)
Follicular Cell, Hyperplasia 6 (12%) 9 (18%) 3 (6%) 5 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05160-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 09:11:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 250 PPM 500 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%) 3 (6%) 3 (6%)
Spermatocele 2 (4%) 1 (2%)
Penis (2)
Congestion 1 (50%)
Preputial Gland (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Cyst 30 (60%) 33 (66%) 26 (52%) 30 (60%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 7 (14%) 5 (10%) 5 (10%)
Inflammation, Chronic Active 6 (12%) 6 (12%) 4 (8%) 7 (14%)
Pigmentation 1 (2%)
Prostate (50) (50) (49) (50)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 3 (6%) 1 (2%) 3 (6%)
Seminal Vesicle (50) (50) (50) (50)
Atrophy 1 (2%)
Hypertrophy 1 (2%) 1 (2%)
Inflammation, Chronic 3 (6%) 9 (18%) 8 (16%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Testes (50) (50) (50) (50)
Germinal Epithelium, Degeneration 1 (2%) 1 (2%) 2 (4%)
Interstitial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Angiectasis 1 (2%)
Hyperplasia, Mast Cell 1 (2%)
Myeloid Cell, Hyperplasia 2 (4%)
Lymph Node (4) (5) (2) (3)
Infiltration Cellular, Plasma Cell 1 (20%)
Iliac, Infiltration Cellular, Plasma Cell 1 (20%)
Iliac, Infiltration Cellular, Histiocyte 1 (25%)
Iliac, Pigmentation 3 (75%) 1 (20%)
Inguinal, Hyperplasia, Lymphoid 1 (20%)
Mediastinal, Hyperplasia, Lymphoid 1 (50%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (20%)
Mediastinal, Pigmentation 1 (25%)
Renal, Angiectasis 1 (20%)
Renal, Hyperplasia, Lymphoid 1 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05160-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 09:11:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 250 PPM 500 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mandibular (50) (50) (50) (50)
Hyperplasia, Lymphoid 2 (4%) 1 (2%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%) 1 (2%)
Lymph Node, Mesenteric (49) (50) (50) (50)
Angiectasis 7 (14%) 8 (16%) 3 (6%) 5 (10%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Spleen (50) (50) (50) (50)
Hematopoietic Cell Proliferation 9 (18%) 8 (16%) 5 (10%) 6 (12%)
Hyperplasia, Lymphoid 1 (2%) 3 (6%)
Lymphoid Follicle, Atrophy 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Epidermis, Cyst 1 (2%)
Epidermis, Necrosis 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Callus 1 (2%)
Fibrous Osteodystrophy 1 (2%)
Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Demyelination 1 (2%)
Hemorrhage 1 (2%)
Thalamus, Mineralization 30 (60%) 25 (50%) 23 (46%) 26 (52%)
Spinal Cord (1)
Demyelination 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 2 (4%) 1 (2%) 2 (4%)
Infiltration Cellular, Histiocyte 2 (4%) 2 (4%) 4 (8%) 5 (10%)
Inflammation, Chronic 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05160-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-CHLORO-2-PROPANOL Date: 07/30/97
Route: DOSED WATER Time: 09:11:09
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 250 PPM 500 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Leukocytosis 1 (2%)
Necrosis 1 (2%)
Alveolar Epithelium, Hyperplasia 5 (10%) 5 (10%) 2 (4%) 3 (6%)
Nose (50) (50) (50) (50)
Foreign Body 1 (2%)
Inflammation, Acute 4 (8%) 1 (2%)
Glands, Amyloid Deposition 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 11 (22%) 13 (26%) 10 (20%) 15 (30%)
Hemorrhage 1 (2%)
Hydronephrosis 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Inflammation, Acute 1 (2%)
Mineralization 5 (10%) 2 (4%)
Nephropathy, Acute 1 (2%) 1 (2%) 6 (12%) 1 (2%)
Nephropathy, Chronic 43 (86%) 45 (90%) 38 (76%) 46 (92%)
Arteriole, Thrombosis 1 (2%)
Papilla, Necrosis 1 (2%)
Pelvis, Calculus Micro Observation Only 1 (2%)
Renal Tubule, Hyperplasia 4 (8%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urethra (1)
Inflammation, Acute 1 (100%)
Urinary Bladder (50) (50) (49) (50)
Calculus Gross Observation 1 (2%)
Calculus Micro Observation Only 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%) 3 (6%) 1 (2%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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