TDMS Study 05160-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research 1-CHLORO-2-PROPANOL DATE: 07/30/97
EXPERIMENT: 05160 TEST: 06 TIME: 08:56:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-05300 ROUTE: DOSED WATER NTP C#: 61983C
PATHOLOGIST: F. VOELKER CAS: 127-00-4
------------------------------------------------------------------------------------------------------------------------------------
2 YEAR CHRONIC
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research 1-CHLORO-2-PROPANOL DATE: 07/30/97
EXPERIMENT: 05160 TEST: 06 TIME: 08:56:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-05300 ROUTE: DOSED WATER NTP C#: 61983C
PATHOLOGIST: F. VOELKER CAS: 127-00-4
1-CHLORO-2-PROPANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 220 380 464 501 518 547 578 646 708 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 335 471 645 665 700 710 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 5 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 377 408 458 458 484 519 519 602 607 608 |
| 625 637 638 645 700 714 |
| CENSORED DEATHS |
| 79 92 180 189 511 |
| |
==================================================================================
1-CHLORO-2-PROPANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 3 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 443 543 556 568 645 652 657 700 |
| CENSORED DEATHS |
| 233 246 617 |
| |
==================================================================================
1-CHLORO-2-PROPANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 98.0 98.0 96.0 94.0 90.0 86.0 84.0 80.0 |
| | |
| | |
|250 PPM | 100.0 100.0 100.0 98.0 98.0 96.0 96.0 96.0 92.0 88.0 |
| | |
| | |
|500 PPM | 100.0 100.0 100.0 100.0 95.7 89.1 84.7 82.4 69.1 64.6 |
| | |
| | |
|1000 PPM | 100.0 100.0 100.0 100.0 100.0 97.9 95.8 91.7 85.3 83.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 250 PPM 500 PPM 1000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 88.0% 64.6% 83.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.986 P=0.386N P=0.151 P=0.824N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 527.6 587.7 562.4 595.5 |
|NATURAL DEATHS (C) | (47.8) (61.7) (25.8) (29.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 688.7 712.0 623.8 685.8 |
|(STANDARD ERROR) | (14.7) ( 9.5) (24.9) (15.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1-CHLORO-2-PROPANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 3 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 465 587 593 657 670 673 677 683 683 714 |
| 721 726 731 732 733 |
| CENSORED DEATHS |
| 76 264 698 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 449 449 538 575 582 594 647 662 663 668 |
| 691 695 703 704 707 710 712 732 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 1 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 50 393 540 543 622 633 645 645 646 649 |
| 655 689 697 |
| CENSORED DEATHS |
| 113 |
| |
==================================================================================
1-CHLORO-2-PROPANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 2 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 150 238 466 523 569 606 616 629 642 646 |
| 664 681 681 701 717 734 |
| CENSORED DEATHS |
| 77 261 |
| |
==================================================================================
1-CHLORO-2-PROPANOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 97.9 97.9 93.8 91.7 68.4 |
| | |
| | |
|250 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 94.0 88.0 82.0 64.0 |
| | |
| | |
|500 PPM | 98.0 98.0 98.0 98.0 96.0 96.0 91.9 91.9 77.6 73.5 |
| | |
| | |
|1000 PPM | 100.0 98.0 95.9 95.9 95.9 93.8 91.7 89.7 77.2 66.7 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 250 PPM 500 PPM 1000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.4% 64.0% 73.5% 66.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.888 P=0.650 P=0.944N P=0.812 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 669.7 637.8 569.8 578.9 |
|NATURAL DEATHS (C) | (18.8) (20.7) (48.8) (41.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 692.1 700.0 679.6 662.4 |
|(STANDARD ERROR) | (17.0) ( 9.9) (19.8) (22.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1-CHLORO-2-PROPANOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
250 PPM = 2
500 PPM = 3
1000 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
102.50 +
|
|1 1 2 3 4
|
98.04 + 1 2 3 1 3 4 2 4
|
| 1 3 312 4 4 2
|
93.59 + 1 1 4 4 2 2
| 1 1 2 2
P | 3 3 4 4
E | 1 1 2 2
R 89.13 + 3 3 44
C | 1 1 2 2
E |
N | 1 14 4
T 84.67 + 3 3
| 1 4 1 4
S | 33
U |
R 80.22 + 1 1
V |
I | 3 3
V |
A 75.76 + 33
L |
| 33
|
71.30 + 33
|
| 3 3
|
66.85 + 3 3
|
| 3 3
|
62.39 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.
1-CHLORO-2-PROPANOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
250 PPM = 2
500 PPM = 3
1000 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 4 2 1
|
| 3 4 4 3 1 1
| 4 3 2 4 23 1 1
95 +
| 4 4 2 2 1 1
| 3 22 3
| 4 4 1 1
P 90 + 4 2 2 4 3 3 11
E |
R | 2 44 3 2
C | 2 2
E 85 + 4 4 11
N | 4 4
T | 22
| 44 1 1
S 80 + 33 2 2
U | 4 4 11
R | 3 4 422 11
V | 22
I 75 + 33 1 1
V | 3 3
A | 4 4
L | 4 4
70 + 22
| 4 1
|
| 2 2
65 +
| 2
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.