TDMS Study 05161-05 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Southern Research Inst RIDDELLIINE DATE: 12/15/00
EXPERIMENT: 05161 TEST: 05 TIME: 12:04:21
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP: C61358C
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: SOUTHERN RESEARCH INSTITUTE RIDDELLIINE DATE: 12/15/00
EXPERIMENT: 05161 TEST: 05 TIME: 12:09:44
SPECIES: RATS, FISCHER 344
TEST TYPE: TWO YEAR ROUTE: ORAL GAVAGE NTP: 61358C
CONT: NO1-ES-55393 CAS: 23246-96-0
MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE
TWO YEAR ORAL GAVAGE STUDY OF RIDDELLIINE
========================================================
WEEK 0 MG/KG/DY 1.0 MG/KG/DY
---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A)
=======================================================
B 119.6 50 119.7 100.1 50
1 119.6 50 119.7 100.1 50
5 244.2 50 239.6 98.1 50
9 316.4 50 306.5 96.9 50
13 361.3 50 349.2 96.7 50
17 392.7 50 374.5 95.4 50
21 418.1 50 396.7 94.9 50
25 435.1 50 404.9 93.1 50
29 449.0 50 418.8 93.3 50
33 465.4 50 431.2 92.7 49
37 474.9 50 440.3 92.7 49
41 486.9 50 449.2 92.3 48
45 491.7 50 452.1 91.9 46
49 501.3 50 454.1 90.6 42
53 506.7 50 456.8 90.2 40
57 509.0 50 452.5 88.9 36
61 510.1 50 438.0 85.9 16
65 513.4 50 424.4 82.7 9
69 519.7 49 411.7 79.2 5
TERM. SAC. 49 3
========================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
TWO YEAR ORAL GAVAGE STUDY OF RIDDELLIINE
==========================================================================================================================
WEEK 0 MG/KG/DY 0.01 MG/KG/DY 0.033 MG/KG/DY 0.1 MG/KG/DY 0.33 MG/KG/DY
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
B 94.7 50 95.1 100.4 50 95.7 101.1 50 95.1 100.4 50 94.7 100.0 50
1 94.7 50 95.1 100.4 50 95.7 101.1 50 95.1 100.4 50 94.7 100.0 50
5 155.0 50 154.1 99.4 50 155.1 100.1 50 152.5 98.4 50 153.1 98.8 50
9 181.8 50 182.5 100.4 50 182.0 100.1 50 178.9 98.4 50 181.2 99.7 50
13 196.4 50 194.5 99.0 50 196.9 100.3 50 194.4 99.0 50 194.6 99.1 50
17 202.5 50 204.3 100.9 50 204.9 101.2 50 202.0 99.8 50 202.7 100.1 50
21 214.4 50 216.0 100.7 50 215.3 100.4 50 212.4 99.1 50 216.5 101.0 50
25 218.2 50 218.9 100.3 50 219.3 100.5 50 217.0 99.5 50 218.9 100.3 50
29 225.9 50 228.0 100.9 50 227.8 100.8 50 223.3 98.8 50 224.2 99.2 50
33 232.9 50 235.1 100.9 50 235.8 101.2 50 232.5 99.8 50 232.2 99.7 50
37 238.2 50 240.2 100.8 50 239.7 100.6 50 236.4 99.2 49 235.9 99.0 50
41 246.8 50 249.1 100.9 50 247.9 100.4 50 245.6 99.5 49 244.5 99.1 50
45 250.7 50 251.7 100.4 50 253.4 101.1 50 250.8 100.0 47 247.9 98.9 50
49 259.1 50 259.9 100.3 49 260.1 100.4 50 255.0 98.4 47 256.4 99.0 50
53 268.3 50 270.7 100.9 49 269.0 100.3 50 266.1 99.2 47 264.3 98.5 50
57 277.1 49 277.4 100.1 49 276.6 99.8 50 272.6 98.4 47 270.5 97.6 50
61 281.1 49 287.1 102.1 48 283.6 100.9 50 279.4 99.4 47 276.7 98.4 50
65 291.9 48 296.1 101.4 48 293.3 100.5 48 288.3 98.8 46 282.3 96.7 50
69 303.9 47 305.6 100.6 48 300.8 99.0 48 295.7 97.3 46 293.5 96.6 48
73 306.5 45 308.3 100.6 48 302.6 98.7 48 300.2 97.9 46 297.0 96.9 48
77 308.5 45 310.7 100.7 45 306.0 99.2 46 301.5 97.7 46 301.3 97.7 47
81 310.4 44 310.5 100.0 44 308.5 99.4 45 304.9 98.2 44 299.4 96.5 47
85 315.1 44 315.9 100.3 43 311.4 98.8 43 310.0 98.4 44 303.8 96.4 42
89 316.2 42 318.3 100.7 39 318.5 100.7 39 311.5 98.5 43 304.4 96.3 41
93 319.4 39 318.1 99.6 32 321.9 100.8 37 309.6 96.9 39 307.8 96.4 39
97 319.9 37 320.3 100.1 29 316.5 98.9 32 311.8 97.5 33 309.3 96.7 33
101 322.1 35 317.7 98.6 26 319.8 99.3 30 315.8 98.0 28 312.8 97.1 29
TERM. SAC. 33 22 28 22 29
==========================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
TWO YEAR ORAL GAVAGE STUDY OF RIDDELLIINE
===============================
1.0 MG/KG/DY
WEEK ----------------
AV.WT. PERCENT NO.
(GRAMS) OF CNTL (A)
==============================
B 94.5 99.8 50
1 94.5 99.8 50
5 153.4 99.0 50
9 178.2 98.0 50
13 189.4 96.4 50
17 196.8 97.2 50
21 206.1 96.1 50
25 207.9 95.3 50
29 212.4 94.0 50
33 219.6 94.3 50
37 223.6 93.9 50
41 232.3 94.1 50
45 233.4 93.1 50
49 239.2 92.3 50
53 245.8 91.6 48
57 251.4 90.7 47
61 254.4 90.5 44
65 260.3 89.2 39
69 272.3 89.6 29
73 269.9 88.1 25
77 267.8 86.8 18
81 264.3 85.1 10
85 284.6 90.3 4
89 289.2 91.5 2
93 262.4 82.2 2
97
101
TERM. SAC. 0
===============================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.