TDMS Study 05161-05 Pathology Tables
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
RATS/FINAL#1
Facility: Southern Research Institute
Chemical CAS #: 23246-96-0
Lock Date: 11/17/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 7| 7| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 0| 8| 0| 4| 0| 1| 1| 1| 1| 1| 6| 6| 1| 8| 2| 8| 9| 9| 9| 9| 0| 7| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Cyst | 3 |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X X X X X X X |
Infiltration Cellular, Mixed Cell | 3 3 1 2 2 2|
Mixed Cell Focus | X X X X X X X |
Necrosis, Focal | 2 |
Bile Duct, Hyperplasia | 1 |
Hepatocyte, Hyperplasia, Focal | |
Hepatocyte, Vacuolization Cytoplasmic| 4 |
|__________________________________________________________________________|
Mesentery | + + + |
Accessory Spleen | |
Fat, Necrosis | 2 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 2 2 2 |
Acinus, Hyperplasia, Focal | 2 |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 7| 7| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 0| 8| 0| 4| 0| 1| 1| 1| 1| 1| 6| 6| 1| 8| 2| 8| 9| 9| 9| 9| 0| 7| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3|
Degeneration, Fatty | 1 3 3 |
Hyperplasia, Focal | 1 2 2 |
Hypertrophy, Focal | 1 2 3 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 |
Pars Distalis, Cyst | 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 1 1 3 2|
Pars Distalis, Hyperplasia | 3 |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 7| 7| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 0| 8| 0| 4| 0| 1| 1| 1| 1| 1| 6| 6| 1| 8| 2| 8| 9| 9| 9| 9| 0| 7| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 1 2 1 1 1 3 1 1 1 |
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 4 |
Hyperplasia | 2 1 2 |
Inflammation, Chronic | 2 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 |
Infiltration Cellular, Mixed Cell | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 3 |
Hyperplasia, Cystic | 2 1 |
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Mediastinal, Congestion | 2 2 |
Mediastinal, Hemorrhage | 3 3 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | 1 4 4 2 3 3 2 3 1 1 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 7| 7| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 0| 8| 0| 4| 0| 1| 1| 1| 1| 1| 6| 6| 1| 8| 2| 8| 9| 9| 9| 9| 0| 7| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Pigmentation | 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Granulomatous | |
Pigmentation | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 1 1 2 2 2 2 1 4 1 |
Pigmentation | 2 2 2 3 2 2 2 3 1 2 3 2 3 2 2 2 2 3 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + I + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 4 3 3 3 3 1 1 2 1 3 3 3 2 3 1 3 2 3 1 2 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 2 3 2 2 |
Femur, Osteopetrosis | 2 3 2 3 4 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 3 4 |
Hemorrhage | 3 |
Hydrocephalus | |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 7| 7| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 0| 8| 0| 4| 0| 1| 1| 1| 1| 1| 6| 6| 1| 8| 2| 8| 9| 9| 9| 9| 0| 7| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 2 3 |
Hemorrhage | 3 4 3 |
Infiltration Cellular, Histiocyte | 2 1 2 2 1 1 2 2 2 1 1 1 2 2 1 2 2 1 1 1 1 1|
Inflammation, Granulomatous | |
Alveolar Epithelium, Hyperplasia | 1 1 2 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 2 |
Respiratory Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Mineralization | 2 |
Renal Tubule, Hyaline Droplet | 2 1 2 1 1 2 1 2 2 1 3 2 1 4 1 2 1|
Renal Tubule, Pigmentation | 2 1 1 1 1 1 1 1 1 1 1 3 2 1 2 2 2 1 1 1 1|
Transitional Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 6
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 6| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 1| 4| 8| 1| 1| 9| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 1| 1| 0| 1| 1| 1| 5| 3| 0| 1| 3| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Diverticulum | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.5|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 45 |
Clear Cell Focus | X X X X X X | 9 |
Cyst | | 1 3.0|
Eosinophilic Focus | X | 1 |
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Hepatodiaphragmatic Nodule | X X X X X | 13 |
Infiltration Cellular, Mixed Cell | 1 2 2| 9 2.0|
Mixed Cell Focus | X | 8 |
Necrosis, Focal | 3 1 1 | 4 1.8|
Bile Duct, Hyperplasia | 1 | 2 1.0|
Hepatocyte, Hyperplasia, Focal | 4 | 1 4.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 2 3 | 4 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 10 |
Accessory Spleen | X X | 2 |
Fat, Necrosis | 2 2 3 3 3 | 8 2.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 6| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 1| 4| 8| 1| 1| 9| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 1| 1| 0| 1| 1| 1| 5| 3| 0| 1| 3| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 2 1 1 | 10 1.9|
Acinus, Hyperplasia, Focal | 2 3 | 3 2.3|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 2 | 12 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 | 6 3.0|
Degeneration, Fatty | 2 1 1 1 2 1| 9 1.7|
Hyperplasia, Focal | 2 | 4 1.8|
Hypertrophy, Focal | 2 2 2 2 2 | 9 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 6| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 1| 4| 8| 1| 1| 9| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 1| 1| 0| 1| 1| 1| 5| 3| 0| 1| 3| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pars Distalis, Angiectasis | 3 4 4| 6 3.0|
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 | 16 3.0|
Pars Distalis, Hyperplasia, Focal | 3 3 2 2 3 2| 10 2.2|
Pars Distalis, Hyperplasia | | 1 3.0|
Pars Intermedia, Angiectasis | | 1 2.0|
Pars Intermedia, Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Ultimobranchial Cyst | 3 | 1 3.0|
C-Cell, Hyperplasia | 1 1 1 1 1 1 2 1 1 2 1| 22 1.3|
Follicle, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Cyst | 3 3 | 5 3.2|
Hyperplasia | | 3 1.7|
Inflammation, Chronic | 3 2 | 4 2.3|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 3 3 | 11 3.0|
Infiltration Cellular, Mixed Cell | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 3 2| 5 2.8|
Hyperplasia, Cystic | 3 1 | 4 1.8|
|__________________________________________________________________________|____________|
Vagina | + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 6| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 1| 4| 8| 1| 1| 9| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 1| 1| 0| 1| 1| 1| 5| 3| 0| 1| 3| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 2 2 | 6 2.5|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 26 |
Mediastinal, Congestion | 1 1 | 4 1.5|
Mediastinal, Hemorrhage | 2 1 2 | 5 2.2|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 4 | 1 4.0|
Mediastinal, Pigmentation | 2 2 1 2 2 1 2 1 1 2 2 1 1 | 23 1.9|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Pigmentation | 2 2 2 | 5 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Inflammation, Granulomatous | 1 | 1 1.0|
Pigmentation | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 4 1 2 1 1 2 1 1 3 2 2 1 2 | 24 1.8|
Pigmentation | 1 3 2 3 1 2 2 2 2 3 2 3 4 1 3 1 2 2| 37 2.2|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 2 3 2 4 4 3 2 2 3 2 2 3 2 4 3 2 3 3 1 2 3| 48 2.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 6| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 1| 4| 8| 1| 1| 9| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 1| 1| 0| 1| 1| 1| 5| 3| 0| 1| 3| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 3 3 2 2 2 2| 10 2.3|
Femur, Osteopetrosis | 2 2 2 4 2 3| 12 2.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 2 4 4 2 | 9 3.2|
Hemorrhage | | 1 3.0|
Hydrocephalus | 2 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 4 2.5|
Hemorrhage | 3 | 4 3.3|
Infiltration Cellular, Histiocyte | 2 1 1 1 1 2 2 2 3 1 1 1 2 2 1 2 1 1 2 2 2 2 1 1| 46 1.5|
Inflammation, Granulomatous | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 5 1.4|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 2 |
Inflammation, Chronic | 1 1 | 3 1.3|
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 6| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 1| 4| 8| 1| 1| 9| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 1| 1| 0| 1| 1| 1| 5| 3| 0| 1| 3| 0| 0| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.0|
Pelvis, Mineralization | | 1 2.0|
Renal Tubule, Hyaline Droplet | 1 1 2 2 3 1 1 1 1 1 1 3 2 2 1 1| 33 1.6|
Renal Tubule, Pigmentation | 2 1 2 2 2 1 1 1 1 1 1 1 3 1 1 1 1| 38 1.3|
Transitional Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 9| 1| 5| 2| 3| 1| 3| 3| 3| 3| 7| 2| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 0| 7| 3|
| 3| 9| 0| 0| 1| 8| 1| 1| 1| 1| 3| 9| 9| 9| 5| 1| 1| 1| 3| 1| 1| 1| 0| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.01 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + A + + + + + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X X |
Infiltration Cellular, Mixed Cell | 2 1 2 1 1 |
Mixed Cell Focus | X X X X |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 4 2 2 2 |
Kupffer Cell, Pigmentation | 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + |
Fat, Necrosis | 3 2 4 3 4 3 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Acinus, Hyperplasia, Focal | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 9| 1| 5| 2| 3| 1| 3| 3| 3| 3| 7| 2| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 0| 7| 3|
| 3| 9| 0| 0| 1| 8| 1| 1| 1| 1| 3| 9| 9| 9| 5| 1| 1| 1| 3| 1| 1| 1| 0| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.01 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 1 1 |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | 3 2 3 2 4 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 3 2 2 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 4 |
Pars Distalis, Cyst | 3 3 |
Pars Distalis, Hyperplasia, Focal | 3 3 2 3 |
Pars Distalis, Hyperplasia | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 2 1 2|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 9| 1| 5| 2| 3| 1| 3| 3| 3| 3| 7| 2| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 0| 7| 3|
| 3| 9| 0| 0| 1| 8| 1| 1| 1| 1| 3| 9| 9| 9| 5| 1| 1| 1| 3| 1| 1| 1| 0| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.01 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 2 3 2 |
Inflammation, Chronic | 2 2 3 3 2 |
|__________________________________________________________________________|
Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Hyperplasia, Cystic | 2 1 4 |
|__________________________________________________________________________|
Vagina | M + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Iliac, Pigmentation | 4 |
Mediastinal, Congestion | 1 |
Mediastinal, Hemorrhage | 2 2 3 |
Mediastinal, Pigmentation | 1 2 2 2 3 2 1 2 3 2 2 2 |
Pancreatic, Hyperplasia, Histiocytic | |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Pigmentation | |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 9| 1| 5| 2| 3| 1| 3| 3| 3| 3| 7| 2| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 0| 7| 3|
| 3| 9| 0| 0| 1| 8| 1| 1| 1| 1| 3| 9| 9| 9| 5| 1| 1| 1| 3| 1| 1| 1| 0| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.01 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 2 2 1 2 2 1 2 2 1 1 1 2 2 2 2 |
Pigmentation | 3 2 3 3 2 3 3 3 2 3 3 3 2 3 3 3 2 2 2 2 2|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia | 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 3 3 3 3 2 3 4 2 3 4 2 2 3 3 2 2 3 2 3 3 4 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | |
Ulcer | 1 |
Epidermis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 2 2 2 4 3 3 2 |
Femur, Osteopetrosis | 2 4 3 4 3 |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 2 3 3 4 2 2 |
Hemorrhage | 3 |
Hydrocephalus | 1 2 3 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 9| 1| 5| 2| 3| 1| 3| 3| 3| 3| 7| 2| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 0| 7| 3|
| 3| 9| 0| 0| 1| 8| 1| 1| 1| 1| 3| 9| 9| 9| 5| 1| 1| 1| 3| 1| 1| 1| 0| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.01 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2 1 1 1 2 2 1 1 2 1 1 1 1 1 1 2 2 1 1 1 2|
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Inflammation, Chronic | 3 |
Nephropathy | 1 1 1 1 1 3 1 1 1 1 1 1 1 1 3 1 1|
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Hyaline Droplet | 2 2 1 2 3 2 1 1 1 1 1 2 1 1 2|
Renal Tubule, Pigmentation | 1 1 1 1 2 2 2 1 1 1 1 1 1 1 1 2 1 1 1|
Transitional Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________|__________________________________________________________________________
Page 17
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 4| 5| 6| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 3| 5| 7| 6| |
DAY ON TEST | 4| 9| 3| 7| 4| 1| 3| 3| 0| 4| 4| 3| 3| 3| 3| 2| 3| 1| 3| 3| 3| 2| 1| 3| 0| |
| 3| 8| 1| 5| 4| 2| 1| 6| 7| 1| 7| 0| 8| 0| 0| 5| 1| 3| 6| 0| 1| 8| 9| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0.01 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + A A + + + + + A + +| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + A + +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 46 |
Clear Cell Focus | X X X| 8 |
Eosinophilic Focus | | 2 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X X | 8 |
Infiltration Cellular, Mixed Cell | 1 2 | 7 1.4|
Mixed Cell Focus | X X X X X X | 10 |
Necrosis, Focal | 2 | 2 1.5|
Bile Duct, Hyperplasia | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 5 2.6|
Kupffer Cell, Pigmentation | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Mesentery | + + | 10 |
Fat, Necrosis | 4 4 | 10 3.2|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 4| 5| 6| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 3| 5| 7| 6| |
DAY ON TEST | 4| 9| 3| 7| 4| 1| 3| 3| 0| 4| 4| 3| 3| 3| 3| 2| 3| 1| 3| 3| 3| 2| 1| 3| 0| |
| 3| 8| 1| 5| 4| 2| 1| 6| 7| 1| 7| 0| 8| 0| 0| 5| 1| 3| 6| 0| 1| 8| 9| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0.01 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Atrophy | 1 2 | 3 1.3|
Acinus, Hyperplasia, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 1 1 1 1 | 15 1.1|
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 | 2 3.0|
Degeneration, Fatty | 2 1 1 2 | 9 2.2|
Hyperplasia, Focal | 1 3 3 2 3 | 5 2.4|
Hypertrophy, Focal | 1 | 5 2.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 3 1.3|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 3 4 3| 6 3.3|
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 | 11 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 4| 5| 6| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 3| 5| 7| 6| |
DAY ON TEST | 4| 9| 3| 7| 4| 1| 3| 3| 0| 4| 4| 3| 3| 3| 3| 2| 3| 1| 3| 3| 3| 2| 1| 3| 0| |
| 3| 8| 1| 5| 4| 2| 1| 6| 7| 1| 7| 0| 8| 0| 0| 5| 1| 3| 6| 0| 1| 8| 9| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0.01 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pars Distalis, Hyperplasia, Focal | 3 2 2 3| 8 2.6|
Pars Distalis, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 3 3| 2 3.0|
C-Cell, Hyperplasia | 1 1 1 1 | 9 1.2|
Follicle, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Cyst | 3 4 | 2 3.5|
Hyperplasia | 2 | 5 2.2|
Inflammation, Chronic | | 5 2.4|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 3 | 7 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 4 3 3 3 3 2 | 7 2.9|
Hyperplasia, Cystic | | 3 2.3|
|__________________________________________________________________________|____________|
Vagina | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 4 2 | 3 2.7|
Myelofibrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 24 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 4| 5| 6| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 3| 5| 7| 6| |
DAY ON TEST | 4| 9| 3| 7| 4| 1| 3| 3| 0| 4| 4| 3| 3| 3| 3| 2| 3| 1| 3| 3| 3| 2| 1| 3| 0| |
| 3| 8| 1| 5| 4| 2| 1| 6| 7| 1| 7| 0| 8| 0| 0| 5| 1| 3| 6| 0| 1| 8| 9| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0.01 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Iliac, Pigmentation | | 1 4.0|
Mediastinal, Congestion | 2 2 | 3 1.7|
Mediastinal, Hemorrhage | 1 3 2 2 2 | 8 2.1|
Mediastinal, Pigmentation | 2 3 3 2 2 2 3 2 3 3 | 22 2.2|
Pancreatic, Hyperplasia, Histiocytic | 3 | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | 2 | 1 2.0|
Pancreatic, Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | 1 3 | 3 2.0|
Pigmentation | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 2 1.5|
Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 2 1 2 1 1 4 2 2 1 1 1 1 1 2 1 | 33 1.5|
Pigmentation | 3 3 2 3 2 3 2 1 3 3 2 3 3 2 2 2 2 3 3 3 | 41 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + M +| 48 |
Hemorrhage | 3 | 2 3.0|
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 2 2 2 1 1 3 1 2 2 4 2 4 2 3 3 2 2 2 | 46 2.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 4| 5| 6| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 3| 5| 7| 6| |
DAY ON TEST | 4| 9| 3| 7| 4| 1| 3| 3| 0| 4| 4| 3| 3| 3| 3| 2| 3| 1| 3| 3| 3| 2| 1| 3| 0| |
| 3| 8| 1| 5| 4| 2| 1| 6| 7| 1| 7| 0| 8| 0| 0| 5| 1| 3| 6| 0| 1| 8| 9| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0.01 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Ulcer | | 1 1.0|
Epidermis, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 2 1 2| 10 2.3|
Femur, Osteopetrosis | 2 2 | 7 2.9|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 3 2 | 11 2.6|
Hemorrhage | | 1 3.0|
Hydrocephalus | 2 | 4 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 3 3 3 | 7 3.1|
Hemorrhage | 3 2 2 3 3 3 | 7 2.6|
Infiltration Cellular, Histiocyte | 1 1 1 1 3 1 1 1 1 1 2 2 2 2 1 2 2 1 2 1| 41 1.4|
Metaplasia, Osseous | 4 | 2 2.5|
Alveolar Epithelium, Hyperplasia | 2 3 | 4 1.8|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 4| 5| 6| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 3| 5| 7| 6| |
DAY ON TEST | 4| 9| 3| 7| 4| 1| 3| 3| 0| 4| 4| 3| 3| 3| 3| 2| 3| 1| 3| 3| 3| 2| 1| 3| 0| |
| 3| 8| 1| 5| 4| 2| 1| 6| 7| 1| 7| 0| 8| 0| 0| 5| 1| 3| 6| 0| 1| 8| 9| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0.01 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 32 1.2|
Renal Tubule, Cytoplasmic Alteration | 2 | 1 2.0|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Hyaline Droplet | 2 2 4 2 2 1 1 2 | 23 1.7|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 | 28 1.1|
Transitional Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 7| 3| 9| 5| 4| 4| 3| 2| 2| 3| 4| 3| 7| 1| 3| 3| 8| 3| 3| 7| 1| 2| 7| 2|
| 1| 5| 1| 1| 4| 7| 7| 0| 9| 9| 0| 7| 0| 2| 5| 1| 1| 8| 1| 1| 1| 6| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.033 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | X |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + I +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + A + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + A A + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + A + + A A + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X|
Degeneration, Cystic | 2 |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | 1 2 2 |
Hemorrhage | 4 |
Hepatodiaphragmatic Nodule | X X |
Infiltration Cellular, Mixed Cell | 3 1 2 2 |
Mixed Cell Focus | X X X X |
Necrosis, Focal | 3 3 1 |
Bile Duct, Hyperplasia | 3 |
Hepatocyte, Cytomegaly | 2 1 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 3 4 |
Kupffer Cell, Pigmentation | 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + + |
Accessory Spleen | X |
Fat, Necrosis | 3 2 3 3 4 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 7| 3| 9| 5| 4| 4| 3| 2| 2| 3| 4| 3| 7| 1| 3| 3| 8| 3| 3| 7| 1| 2| 7| 2|
| 1| 5| 1| 1| 4| 7| 7| 0| 9| 9| 0| 7| 0| 2| 5| 1| 1| 8| 1| 1| 1| 6| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.033 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Atrophy | 3 1 2 3 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 |
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 |
Degeneration, Fatty | 2 3 3 1 1 1 3 |
Hyperplasia, Diffuse | 2 |
Hyperplasia, Focal | 1 1 4 |
Hypertrophy, Focal | 2 2 2 |
Hypertrophy | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 4 |
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 7| 3| 9| 5| 4| 4| 3| 2| 2| 3| 4| 3| 7| 1| 3| 3| 8| 3| 3| 7| 1| 2| 7| 2|
| 1| 5| 1| 1| 4| 7| 7| 0| 9| 9| 0| 7| 0| 2| 5| 1| 1| 8| 1| 1| 1| 6| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.033 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Intermedia, Cyst | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 2 1 1 1 1 1 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + I + + + +|
Cyst | 3 4 |
Hyperplasia | 2 2 2|
Inflammation, Chronic | 4 4 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 4 1 |
Inflammation, Chronic | 4 4 |
|__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 4 3 3 |
Inflammation, Granulomatous | 2|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 1 |
Mediastinal, Hemorrhage | 3 2 2 3 2 2 3|
Mediastinal, Pigmentation | 2 3 1 2 3 2 1 2 3 2 1 3 4 2 1 2|
Pancreatic, Hyperplasia, Histiocytic | |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Pigmentation | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 7| 3| 9| 5| 4| 4| 3| 2| 2| 3| 4| 3| 7| 1| 3| 3| 8| 3| 3| 7| 1| 2| 7| 2|
| 1| 5| 1| 1| 4| 7| 7| 0| 9| 9| 0| 7| 0| 2| 5| 1| 1| 8| 1| 1| 1| 6| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.033 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Renal, Pigmentation | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 1 |
Pigmentation | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 3 4 1 4 2 3 3 1 2 1 2 1 2 |
Pigmentation | 2 2 3 3 2 2 3 2 2 2 3 3 3 3 3 2 2 2 3|
|__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 4 3 2 3 2 4 3 2 2 2 4 3 3 3 3 4 4 2 2 3|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 3 4 3 4 3 |
Femur, Osteopetrosis | 2 3 4 2 4 |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 1 3 2 1 2 3 2 3 3 3 |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 7| 3| 9| 5| 4| 4| 3| 2| 2| 3| 4| 3| 7| 1| 3| 3| 8| 3| 3| 7| 1| 2| 7| 2|
| 1| 5| 1| 1| 4| 7| 7| 0| 9| 9| 0| 7| 0| 2| 5| 1| 1| 8| 1| 1| 1| 6| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.033 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Hydrocephalus | 2 3 2 2 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 1 1 1 2 1 2 1 1 1 3 1 3 2 1 1 2 1 2|
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 3 2 2 1 1 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Olfactory Epithelium, Degeneration | |
Respiratory Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Papilla, Fibrosis, Focal | |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Hyaline Droplet | 2 1 2 1 1 1 1 1 1 1 1 2 1 2|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 3 2|
Transitional Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
__________________________________________|__________________________________________________________________________
Page 28
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 5| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 6| 1| 9| 3| 1| 3| 1| 2| 3| 4| 2| 2| 3| 9| 3| 2| 3| 2| 2| 2| 5| 2| |
| 1| 1| 1| 2| 8| 1| 0| 7| 0| 5| 9| 2| 4| 9| 9| 0| 4| 7| 9| 0| 9| 9| 9| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.033 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + M + + + + + + + + + M + +| 48 |
Perforation | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + M + + +| 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2| 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 44 |
Clear Cell Focus | X X X X X X | 9 |
Degeneration, Cystic | | 1 2.0|
Eosinophilic Focus | X X X| 6 |
Hematopoietic Cell Proliferation | 3 | 4 2.0|
Hemorrhage | 3 | 2 3.5|
Hepatodiaphragmatic Nodule | X X X X X X X| 9 |
Infiltration Cellular, Mixed Cell | 1 1 3 1 3| 9 1.9|
Mixed Cell Focus | X X X X X X| 10 |
Necrosis, Focal | | 3 2.3|
Bile Duct, Hyperplasia | 2 1 1 | 4 1.8|
Hepatocyte, Cytomegaly | 1 1 | 7 1.1|
Hepatocyte, Vacuolization Cytoplasmic| 2 4 2 4 | 7 2.9|
Kupffer Cell, Pigmentation | 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 5| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 6| 1| 9| 3| 1| 3| 1| 2| 3| 4| 2| 2| 3| 9| 3| 2| 3| 2| 2| 2| 5| 2| |
| 1| 1| 1| 2| 8| 1| 0| 7| 0| 5| 9| 2| 4| 9| 9| 0| 4| 7| 9| 0| 9| 9| 9| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.033 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Accessory Spleen | | 1 |
Fat, Necrosis | 2 2 3 4 4 4 3 2 3 3 3 | 18 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 2 1 | 9 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 3 3 | 2 3.0|
Epithelium, Hyperplasia | 3 2 2 2 | 5 2.2|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tongue | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 2 | 8 1.5|
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 | 6 3.0|
Degeneration, Fatty | 2 2 2 2 2 | 12 2.0|
Hyperplasia, Diffuse | 2 3 | 3 2.3|
Hyperplasia, Focal | 2 1 2 | 6 1.8|
Hypertrophy, Focal | 2 2 1 2 | 7 1.9|
Hypertrophy | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 5| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 6| 1| 9| 3| 1| 3| 1| 2| 3| 4| 2| 2| 3| 9| 3| 2| 3| 2| 2| 2| 5| 2| |
| 1| 1| 1| 2| 8| 1| 0| 7| 0| 5| 9| 2| 4| 9| 9| 0| 4| 7| 9| 0| 9| 9| 9| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.033 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 2 2 3 3 2 | 8 2.6|
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 3 3 | 19 3.0|
Pars Distalis, Hyperplasia, Focal | 3 2 2 2 1 3 2 4 2 | 9 2.3|
Pars Intermedia, Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 24 1.2|
Follicle, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 3 3.3|
Hyperplasia | 2 | 4 2.0|
Inflammation, Chronic | 3 | 4 3.3|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 | 8 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 3 1 1 2 | 7 2.1|
Inflammation, Chronic | | 2 4.0|
|__________________________________________________________________________|____________|
Vagina | + | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 5| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 6| 1| 9| 3| 1| 3| 1| 2| 3| 4| 2| 2| 3| 9| 3| 2| 3| 2| 2| 2| 5| 2| |
| 1| 1| 1| 2| 8| 1| 0| 7| 0| 5| 9| 2| 4| 9| 9| 0| 4| 7| 9| 0| 9| 9| 9| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.033 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 | 8 2.9|
Inflammation, Granulomatous | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + +| 36 |
Mediastinal, Congestion | 2 1 | 3 1.3|
Mediastinal, Hemorrhage | 3 2 | 9 2.4|
Mediastinal, Pigmentation | 2 2 2 2 2 2 2 1 2 2 2 3 3 2 1 2| 32 2.1|
Pancreatic, Hyperplasia, Histiocytic | 3 | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | 2 | 1 2.0|
Pancreatic, Pigmentation | | 2 2.0|
Renal, Pigmentation | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + M + + + +| 48 |
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation | | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 3 2.7|
Pigmentation | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 2 1.5|
Hematopoietic Cell Proliferation | 2 2 4 1 2 2 2 1 1 1 3 1 | 25 2.0|
Pigmentation | 2 4 3 2 1 3 2 2 2 2 3 2 2 3 2 2| 35 2.4|
|__________________________________________________________________________|____________|
Thymus | + M M + + + + + + + + + + + M + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 4 3 3 4 2 2 3 4 3 2 1 3 3 3 3 2 2 3 2 1 1| 46 2.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 5| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 6| 1| 9| 3| 1| 3| 1| 2| 3| 4| 2| 2| 3| 9| 3| 2| 3| 2| 2| 2| 5| 2| |
| 1| 1| 1| 2| 8| 1| 0| 7| 0| 5| 9| 2| 4| 9| 9| 0| 4| 7| 9| 0| 9| 9| 9| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.033 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + I + + + + + + + + + + +| 49 |
Hyperkeratosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 3 4 3 2 3 2 | 12 3.1|
Femur, Osteopetrosis | 3 4 3 2 | 9 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 3 4 | 15 2.5|
Hydrocephalus | 2 2 2 2 | 8 2.1|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 2 3.5|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 1 2 1 1 1 1 1 1 3 4 2 2 3 1 1 1 1 1 1 2 2 3 2| 48 1.5|
Inflammation, Chronic | 2| 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 | 10 1.4|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Olfactory Epithelium, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 5| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 6| 1| 9| 3| 1| 3| 1| 2| 3| 4| 2| 2| 3| 9| 3| 2| 3| 2| 2| 2| 5| 2| |
| 1| 1| 1| 2| 8| 1| 0| 7| 0| 5| 9| 2| 4| 9| 9| 0| 4| 7| 9| 0| 9| 9| 9| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.033 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Respiratory Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 2 | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1| 33 1.1|
Papilla, Fibrosis, Focal | 2 | 1 2.0|
Renal Tubule, Dilatation | 2 | 2 2.0|
Renal Tubule, Hyaline Droplet | 1 1 2 1 1 3 1 2 1 3 2 2 1 2 1 1| 30 1.4|
Renal Tubule, Pigmentation | 1 1 1 2 2 1 3 1 1 2 1 1 1 1 1| 31 1.3|
Transitional Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 0| 2| 2| 2| 2| 2| 2| 1| 6| 2| 9| 6| 3| 3| 1| 3| 3| 3| 0| 3| 3| 4| 3| 5| 3|
| 7| 9| 9| 9| 9| 9| 9| 8| 4| 9| 1| 8| 0| 0| 5| 0| 0| 0| 7| 0| 0| 6| 0| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + A + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X X |
Infiltration Cellular, Mixed Cell | 2 1 3 |
Mixed Cell Focus | X X X X X X X |
Necrosis, Focal | 1 1|
Bile Duct, Hyperplasia | 1 1 |
Hepatocyte, Cytomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 |
Kupffer Cell, Pigmentation | 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Accessory Spleen | X |
Fat, Necrosis | 2 4 3 2 3 4 3 |
|__________________________________________________________________________|
Oral Mucosa | + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + M + + + + + +|
Atrophy | 1 3 1 1 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 0| 2| 2| 2| 2| 2| 2| 1| 6| 2| 9| 6| 3| 3| 1| 3| 3| 3| 0| 3| 3| 4| 3| 5| 3|
| 7| 9| 9| 9| 9| 9| 9| 8| 4| 9| 1| 8| 0| 0| 5| 0| 0| 0| 7| 0| 0| 6| 0| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Atrophy | 3 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + I + + + + + +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2|
Ulcer | 2 |
|__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 |
Degeneration, Fatty | 1 2 3 |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 1 3 |
Hypertrophy, Focal | 1 |
Hypertrophy | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 3 4 |
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 3|
Pars Distalis, Hyperplasia, Focal | 3 1 2 3 3 3 4 1 2|
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 0| 2| 2| 2| 2| 2| 2| 1| 6| 2| 9| 6| 3| 3| 1| 3| 3| 3| 0| 3| 3| 4| 3| 5| 3|
| 7| 9| 9| 9| 9| 9| 9| 8| 4| 9| 1| 8| 0| 0| 5| 0| 0| 0| 7| 0| 0| 6| 0| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Intermedia, Angiectasis | 4 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 3 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + M + + + + + +|
Cyst | 3 |
Hyperplasia | |
Inflammation, Chronic | 2 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Hyperplasia, Cystic | 2 1 1 3 |
|__________________________________________________________________________|
Vagina | M + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Myelofibrosis | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Mediastinal, Congestion | 2 |
Mediastinal, Hemorrhage | 1 1 |
Mediastinal, Pigmentation | 2 2 2 2 1 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 2 |
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 0| 2| 2| 2| 2| 2| 2| 1| 6| 2| 9| 6| 3| 3| 1| 3| 3| 3| 0| 3| 3| 4| 3| 5| 3|
| 7| 9| 9| 9| 9| 9| 9| 8| 4| 9| 1| 8| 0| 0| 5| 0| 0| 0| 7| 0| 0| 6| 0| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia, Lymphoid | 3 2 2 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 1 |
Pigmentation | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 1 3 2 2 1 1 2 3 1 3 2 1 2 1 2 |
Necrosis | |
Pigmentation | 2 2 2 3 3 2 2 2 3 2 2 2 3 2 2 2 |
|__________________________________________________________________________|
Thymus | M + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 2 4 3 3 2 2 2 4 3 2 2 3 2 4 3 3 1 3 2 3|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 4 3 4 |
Femur, Osteopetrosis | 3 1 3 2 4 2 4 2 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 2 3 3 |
Hemorrhage | |
Hydrocephalus | |
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 0| 2| 2| 2| 2| 2| 2| 1| 6| 2| 9| 6| 3| 3| 1| 3| 3| 3| 0| 3| 3| 4| 3| 5| 3|
| 7| 9| 9| 9| 9| 9| 9| 8| 4| 9| 1| 8| 0| 0| 5| 0| 0| 0| 7| 0| 0| 6| 0| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 4 2 |
Hemorrhage | 4 |
Infiltration Cellular, Histiocyte | 1 2 1 1 2 2 2 1 1 2 1 1 2 1 1 3 1 1 3 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 1 1 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 3 1 |
Olfactory Epithelium, Degeneration | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Cytoplasmic Alteration | 2 |
Renal Tubule, Hyaline Droplet | 3 2 2 1 3 3 2 1 3 1 1 4 1 1 2 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 3 1 1 1 1 1 1 1 1 1 1 1 4 1 1 3 |
Transitional Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 39
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 6| 5| 7| 2| 7| 6| 7| 2| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| |
DAY ON TEST | 4| 1| 5| 6| 6| 2| 9| 2| 5| 1| 5| 7| 8| 2| 3| 3| 3| 3| 3| 0| 7| 3| 5| 8| 5| |
| 2| 8| 1| 0| 1| 9| 3| 9| 0| 0| 2| 8| 2| 6| 8| 1| 1| 1| 1| 7| 8| 1| 8| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0.1 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + A| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + A| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + A + + + + + + + + + + + + + + + + + A| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + A + + + + + + + + + + + + + + + + + A| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + A + + + + A + A + + + + + + + + + + A| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + A + + + + A + + + + + + + + + + + + A| 43 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 42 |
Clear Cell Focus | X X X X | 13 |
Eosinophilic Focus | X X X | 4 |
Hepatodiaphragmatic Nodule | X X | 6 |
Infiltration Cellular, Mixed Cell | 2 1 2 1 3 | 8 1.9|
Mixed Cell Focus | X X X X | 11 |
Necrosis, Focal | 1 3 | 4 1.5|
Bile Duct, Hyperplasia | 2 2 | 4 1.5|
Hepatocyte, Cytomegaly | 1 1 1 2 1 1 1 3 2 1 | 23 1.2|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 4 2.3|
Kupffer Cell, Pigmentation | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 14 |
Accessory Spleen | X | 2 |
Fat, Necrosis | 3 4 3 3 4 | 12 3.2|
|__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 6| 5| 7| 2| 7| 6| 7| 2| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| |
DAY ON TEST | 4| 1| 5| 6| 6| 2| 9| 2| 5| 1| 5| 7| 8| 2| 3| 3| 3| 3| 3| 0| 7| 3| 5| 8| 5| |
| 2| 8| 1| 0| 1| 9| 3| 9| 0| 0| 2| 8| 2| 6| 8| 1| 1| 1| 1| 7| 8| 1| 8| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0.1 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Pancreas | M + + + + + A + + + + + + + + + + + + + + + + + A| 46 |
Atrophy | 1 3 | 8 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 2 | 2 2.0|
Ulcer | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Tooth | | 1 |
Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 2 1 | 13 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 | 4 3.0|
Degeneration, Fatty | 3 3 1 3 1 | 8 2.1|
Hyperplasia, Diffuse | 3 | 1 3.0|
Hyperplasia, Focal | 1 2 | 4 1.8|
Hypertrophy, Focal | 3 | 2 2.0|
Hypertrophy | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 6| 5| 7| 2| 7| 6| 7| 2| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| |
DAY ON TEST | 4| 1| 5| 6| 6| 2| 9| 2| 5| 1| 5| 7| 8| 2| 3| 3| 3| 3| 3| 0| 7| 3| 5| 8| 5| |
| 2| 8| 1| 0| 1| 9| 3| 9| 0| 0| 2| 8| 2| 6| 8| 1| 1| 1| 1| 7| 8| 1| 8| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0.1 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Islets, Pancreatic | M + + + + + A + + + + + + + + + + + + + + + + + A| 46 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + A M + + + + + + + + + M + + + + M + +| 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Pars Distalis, Angiectasis | 4 4 2 4 | 8 3.3|
Pars Distalis, Cyst | 3 3 3 3 3 3 | 16 3.0|
Pars Distalis, Hyperplasia, Focal | 2 3 | 11 2.5|
Pars Intermedia, Angiectasis | | 1 4.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 3 3 2 1 1 | 15 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 1 3.0|
Hyperplasia | 1 2 | 2 1.5|
Inflammation, Chronic | 3 | 3 2.7|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 3 | 9 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 2 2 2 4 | 6 2.3|
Hyperplasia, Cystic | 2 | 5 1.8|
|__________________________________________________________________________|____________|
Vagina | + + + | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 6| 5| 7| 2| 7| 6| 7| 2| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| |
DAY ON TEST | 4| 1| 5| 6| 6| 2| 9| 2| 5| 1| 5| 7| 8| 2| 3| 3| 3| 3| 3| 0| 7| 3| 5| 8| 5| |
| 2| 8| 1| 0| 1| 9| 3| 9| 0| 0| 2| 8| 2| 6| 8| 1| 1| 1| 1| 7| 8| 1| 8| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0.1 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 3 2 2 | 7 2.9|
Myelofibrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + +| 19 |
Mediastinal, Congestion | 2 3| 3 2.3|
Mediastinal, Hemorrhage | 2 2 4 | 5 2.0|
Mediastinal, Pigmentation | 2 2 2 1 2 2 3 2 2| 15 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 3 2.3|
Hyperplasia, Lymphoid | | 5 2.2|
Pigmentation | 2 2 2 | 11 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + A + + + + + + + + + + + + + + + + + A| 47 |
Congestion | 3 | 1 3.0|
Hemorrhage | 3 3 | 4 2.3|
Pigmentation | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 1 1 2 3 2 3 2 4 1 | 26 2.0|
Necrosis | 3 | 1 3.0|
Pigmentation | 2 2 3 3 2 2 2 3 2 3 3 3 2 2 3 3 2 3| 34 2.4|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 4 2 2 3 2 4 1 3 4 3 2 3 2 3 3 3 3 3| 45 2.7|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 6| 5| 7| 2| 7| 6| 7| 2| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| |
DAY ON TEST | 4| 1| 5| 6| 6| 2| 9| 2| 5| 1| 5| 7| 8| 2| 3| 3| 3| 3| 3| 0| 7| 3| 5| 8| 5| |
| 2| 8| 1| 0| 1| 9| 3| 9| 0| 0| 2| 8| 2| 6| 8| 1| 1| 1| 1| 7| 8| 1| 8| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0.1 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Subcutaneous Tissue, Edema | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 3 2 2 | 6 3.0|
Femur, Osteopetrosis | 3 3 3 2 2 2 2| 15 2.5|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 4 | 6 3.2|
Hemorrhage | 3 2 1 | 3 2.0|
Hydrocephalus | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 3 | 8 3.0|
Hemorrhage | 3 2 | 3 3.0|
Infiltration Cellular, Histiocyte | 1 2 2 1 1 1 2 2 1 1 2 2 1 2 2 1 1 1 1 1| 44 1.4|
Alveolar Epithelium, Hyperplasia | 2 2 | 5 1.6|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Foreign Body | | 1 |
Inflammation, Chronic | | 2 2.0|
Olfactory Epithelium, Degeneration | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 6| 5| 7| 2| 7| 6| 7| 2| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| |
DAY ON TEST | 4| 1| 5| 6| 6| 2| 9| 2| 5| 1| 5| 7| 8| 2| 3| 3| 3| 3| 3| 0| 7| 3| 5| 8| 5| |
| 2| 8| 1| 0| 1| 9| 3| 9| 0| 0| 2| 8| 2| 6| 8| 1| 1| 1| 1| 7| 8| 1| 8| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0.1 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.0|
Renal Tubule, Cytoplasmic Alteration | | 1 2.0|
Renal Tubule, Hyaline Droplet | 3 2 1 1 1 2 1 2 1 2 2 | 26 1.8|
Renal Tubule, Necrosis | 3 | 1 3.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 2 1 1 1 1 2 1 1 3 1 | 31 1.4|
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + A| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 5| 8| 3| 7| 2| 9| 3| 2| 5| 2| 2| 2| 3| 3| 3| 3| 5| 9| 3| 3| 8| 3|
| 4| 0| 0| 4| 7| 0| 0| 9| 0| 0| 9| 1| 9| 9| 9| 1| 1| 1| 0| 7| 7| 1| 1| 6| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.33 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + I + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X|
Degeneration, Cystic | |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 4 |
Hepatodiaphragmatic Nodule | X X |
Infiltration Cellular, Mixed Cell | 3 1 2 1 2 2 2 2 |
Mixed Cell Focus | X X X X X X X X X X|
Necrosis, Focal | 4 1 |
Bile Duct, Hyperplasia | 3 1 |
Hepatocyte, Cytomegaly | 3 2 1 1 1 2 1 2 2 3 1 1 2 2 2 2 2 1 2|
Hepatocyte, Hyperplasia, Atypical | |
Hepatocyte, Hyperplasia, Regenerative| 3 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 3 |
Kupffer Cell, Pigmentation | 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Accessory Spleen | X |
Fat, Necrosis | 3 3 2 3 |
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 5| 8| 3| 7| 2| 9| 3| 2| 5| 2| 2| 2| 3| 3| 3| 3| 5| 9| 3| 3| 8| 3|
| 4| 0| 0| 4| 7| 0| 0| 9| 0| 0| 9| 1| 9| 9| 9| 1| 1| 1| 0| 7| 7| 1| 1| 6| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.33 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 |
Acinus, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + M + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + M + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 |
Atrophy | 3 |
Degeneration, Fatty | 4 1 3 3 3 1 1 2 |
Hyperplasia, Focal | 2 1 2 2 2|
Hypertrophy, Focal | 2 1 |
Necrosis | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 3 3 3 |
Pars Distalis, Cyst | 3 3 3 3 3 |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 5| 8| 3| 7| 2| 9| 3| 2| 5| 2| 2| 2| 3| 3| 3| 3| 5| 9| 3| 3| 8| 3|
| 4| 0| 0| 4| 7| 0| 0| 9| 0| 0| 9| 1| 9| 9| 9| 1| 1| 1| 0| 7| 7| 1| 1| 6| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.33 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Distalis, Hyperplasia, Focal | 2 1 3 |
Pars Intermedia, Angiectasis | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 |
C-Cell, Hyperplasia | 1 2 1 2 1 1 1 3 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | 3 4 3 |
Hyperplasia | 2 |
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 3 |
Hyperplasia, Cystic | 2 2 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Vagina | + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 |
Myelofibrosis | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Mediastinal, Congestion | 1 |
Mediastinal, Hemorrhage | 2 2 2 3 |
Mediastinal, Pigmentation | 3 1 2 2 2 2 2 4 2 1 |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 5| 8| 3| 7| 2| 9| 3| 2| 5| 2| 2| 2| 3| 3| 3| 3| 5| 9| 3| 3| 8| 3|
| 4| 0| 0| 4| 7| 0| 0| 9| 0| 0| 9| 1| 9| 9| 9| 1| 1| 1| 0| 7| 7| 1| 1| 6| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.33 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pancreatic, Pigmentation | 3 2|
Renal, Pigmentation | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 3 |
Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + I + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Pigmentation | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 2 |
Fibrosis | 3 3 |
Hematopoietic Cell Proliferation | 4 2 2 3 2 1 2 4 2 1 1 1 1 |
Hyperplasia, Stromal | |
Pigmentation | 3 2 3 3 3 2 2 2 2 4 3 2 3 2 2 2 3 2 2 3|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 4 3 3 3 2 1 2 4 3 2 4 4 3 3 3 3 2 3 1|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 3 4 2 2 4 |
Femur, Osteopetrosis | 4 2 2 4 3 4 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 5| 8| 3| 7| 2| 9| 3| 2| 5| 2| 2| 2| 3| 3| 3| 3| 5| 9| 3| 3| 8| 3|
| 4| 0| 0| 4| 7| 0| 0| 9| 0| 0| 9| 1| 9| 9| 9| 1| 1| 1| 0| 7| 7| 1| 1| 6| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.33 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 4 3 1 4 3 |
Hydrocephalus | 2 2 3 3 |
|__________________________________________________________________________|
Peripheral Nerve | + + |
|__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 4 |
Hemorrhage | 4 3 |
Infiltration Cellular, Histiocyte | 4 1 1 1 2 1 1 1 2 2 3 1 1 1 1 1 2 1 1 1 1 1 1 2|
Alveolar Epithelium, Hyperplasia | 2 1 1 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3|
Hydronephrosis | |
Infarct | |
Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Hyaline Droplet | 1 1 1 2 2 2 1 3 1 3 1 1|
Renal Tubule, Necrosis | 2 |
Renal Tubule, Pigmentation | 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 5| 8| 3| 7| 2| 9| 3| 2| 5| 2| 2| 2| 3| 3| 3| 3| 5| 9| 3| 3| 8| 3|
| 4| 0| 0| 4| 7| 0| 0| 9| 0| 0| 9| 1| 9| 9| 9| 1| 1| 1| 0| 7| 7| 1| 1| 6| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.33 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 51
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 2| 2| 7| 2| 8| 2| 2| 2| 6| 3| 5| 7| 3| 3| 5| 5| 3| 1| 8| 2| 2| 2| 2| 0| |
| 1| 9| 9| 6| 9| 0| 9| 9| 9| 3| 0| 8| 1| 0| 0| 4| 6| 0| 9| 6| 9| 9| 9| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.33 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + I + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3| 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 3 | 5 2.8|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X | 40 |
Clear Cell Focus | X X X X X X X X X X | 22 |
Degeneration, Cystic | 3 | 1 3.0|
Eosinophilic Focus | X X X X X X X X X X | 12 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hemorrhage | | 1 4.0|
Hepatodiaphragmatic Nodule | X X | 4 |
Infiltration Cellular, Mixed Cell | 1 3 2 3 2 2 2 | 15 2.0|
Mixed Cell Focus | X X X X X X X X X X X X X | 23 |
Necrosis, Focal | 1 1 | 4 1.8|
Bile Duct, Hyperplasia | 2 | 3 2.0|
Hepatocyte, Cytomegaly | 2 1 2 3 2 3 2 2 2 2 2 2 2 | 32 1.9|
Hepatocyte, Hyperplasia, Atypical | 4 | 1 4.0|
Hepatocyte, Hyperplasia, Regenerative| 2 4 3 3 2 3 | 8 2.8|
Hepatocyte, Vacuolization Cytoplasmic| | 3 2.7|
Kupffer Cell, Pigmentation | 2 2 4 3 2| 6 2.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 2| 2| 7| 2| 8| 2| 2| 2| 6| 3| 5| 7| 3| 3| 5| 5| 3| 1| 8| 2| 2| 2| 2| 0| |
| 1| 9| 9| 6| 9| 0| 9| 9| 9| 3| 0| 8| 1| 0| 0| 4| 6| 0| 9| 6| 9| 9| 9| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.33 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + +| 13 |
Accessory Spleen | | 1 |
Fat, Necrosis | 3 3 4 3 4 | 9 3.1|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 4 1.8|
Acinus, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | 2| 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 1 2 | 8 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 2 3.0|
Atrophy | | 1 3.0|
Degeneration, Fatty | 1 3 3 1 2 | 13 2.2|
Hyperplasia, Focal | 1 2 2 1 | 9 1.7|
Hypertrophy, Focal | 3 2 | 4 2.0|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 | 3 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 2| 2| 7| 2| 8| 2| 2| 2| 6| 3| 5| 7| 3| 3| 5| 5| 3| 1| 8| 2| 2| 2| 2| 0| |
| 1| 9| 9| 6| 9| 0| 9| 9| 9| 3| 0| 8| 1| 0| 0| 4| 6| 0| 9| 6| 9| 9| 9| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.33 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + I + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 3 3 2 2 | 9 2.8|
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 3 3 3| 17 3.0|
Pars Distalis, Hyperplasia, Focal | 3 2 3 2 | 7 2.3|
Pars Intermedia, Angiectasis | | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 3.0|
C-Cell, Hyperplasia | 3 1 1 3 1 1 1 1 3 | 20 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 4 3.3|
Hyperplasia | 2| 2 2.0|
Inflammation, Chronic | 2 2 3| 4 2.3|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 6 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 3 3 2 | 6 2.5|
Hyperplasia, Cystic | | 2 2.0|
Inflammation, Chronic | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Vagina | + + | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 2| 2| 7| 2| 8| 2| 2| 2| 6| 3| 5| 7| 3| 3| 5| 5| 3| 1| 8| 2| 2| 2| 2| 0| |
| 1| 9| 9| 6| 9| 0| 9| 9| 9| 3| 0| 8| 1| 0| 0| 4| 6| 0| 9| 6| 9| 9| 9| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.33 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 2 2 2 2 2 | 10 2.2|
Myelofibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + +| 21 |
Mediastinal, Congestion | | 1 1.0|
Mediastinal, Hemorrhage | 1 2 3 | 7 2.1|
Mediastinal, Pigmentation | 1 2 2 2 2 2 | 16 2.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Pancreatic, Pigmentation | 2 2 | 4 2.3|
Renal, Pigmentation | 4 | 2 3.5|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | 2 2 1 | 5 2.0|
Pigmentation | 2 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
Pigmentation | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 3 2.3|
Fibrosis | | 2 3.0|
Hematopoietic Cell Proliferation | 1 2 1 3 2 1 2 1 1 3 2 2 1 2 | 27 1.9|
Hyperplasia, Stromal | 3 | 1 3.0|
Pigmentation | 3 2 3 2 2 3 2 2 2 2 2 3 3 2 2 | 35 2.4|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 2| 2| 7| 2| 8| 2| 2| 2| 6| 3| 5| 7| 3| 3| 5| 5| 3| 1| 8| 2| 2| 2| 2| 0| |
| 1| 9| 9| 6| 9| 0| 9| 9| 9| 3| 0| 8| 1| 0| 0| 4| 6| 0| 9| 6| 9| 9| 9| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.33 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Hyperplasia | 2 2 3 2 3 2 3 1 4 3 1 3 2 3 2 3 3 3 3 2 2 | 44 2.6|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X| 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 4 | 7 3.1|
Femur, Osteopetrosis | 3 3 2 2 2 4 2 | 14 2.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 4 3 4 4 | 12 3.3|
Hydrocephalus | 2 3 2 3 2 2 | 10 2.4|
|__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
|__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Edema | | 1 4.0|
Hemorrhage | 4 4 2 | 5 3.4|
Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 1 1 1 1 2 2 1 1 1 1 1 2 1 1 1 1 2 1 2| 50 1.3|
Alveolar Epithelium, Hyperplasia | 1 | 5 1.4|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 2| 2| 7| 2| 8| 2| 2| 2| 6| 3| 5| 7| 3| 3| 5| 5| 3| 1| 8| 2| 2| 2| 2| 0| |
| 1| 9| 9| 6| 9| 0| 9| 9| 9| 3| 0| 8| 1| 0| 0| 4| 6| 0| 9| 6| 9| 9| 9| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.33 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Hydronephrosis | 2 | 1 2.0|
Infarct | 2 | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1| 38 1.1|
Renal Tubule, Dilatation | 2 | 2 2.0|
Renal Tubule, Hyaline Droplet | 1 2 1 1 1 3 3 2 1 1 2 1 2 2| 26 1.6|
Renal Tubule, Necrosis | | 1 2.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 2 2 3 1 1 1 2 1 1 1 1 2| 41 1.2|
|__________________________________________________________________________|____________|
Ureter | + | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 4| 4| 5| 4| 5| 5| 5| 4| 3| 5| 4| 4| 6| 3| 5| 4| 6| 5| 3| 4| 4|
DAY ON TEST | 8| 5| 8| 2| 6| 6| 0| 2| 4| 2| 8| 6| 9| 7| 0| 7| 6| 5| 2| 7| 0| 2| 5| 5| 4|
| 8| 2| 1| 8| 1| 9| 3| 3| 1| 2| 7| 1| 3| 3| 0| 6| 8| 0| 7| 2| 8| 8| 2| 9| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X X |
Hematopoietic Cell Proliferation | 2 2|
Hemorrhage | 3 3 3 4 |
Hepatodiaphragmatic Nodule | X X X |
Infiltration Cellular, Mixed Cell | 1 |
Mixed Cell Focus | X X |
Necrosis, Focal | 2 3 1 3 4 3 4 1|
Bile Duct, Hyperplasia | 2 2 2 2 |
Hepatocyte, Cytomegaly | 2 2 3 3 3 2 2 2 2 3 2 2|
Hepatocyte, Hyperplasia, Regenerative| 3 3 4 3 4 3 4 4 4 4 4 3 3 4 4 3 4 4 4 4 4 4 3 3 3|
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Kupffer Cell, Pigmentation | 2 4 2 |
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 4| 4| 5| 4| 5| 5| 5| 4| 3| 5| 4| 4| 6| 3| 5| 4| 6| 5| 3| 4| 4|
DAY ON TEST | 8| 5| 8| 2| 6| 6| 0| 2| 4| 2| 8| 6| 9| 7| 0| 7| 6| 5| 2| 7| 0| 2| 5| 5| 4|
| 8| 2| 1| 8| 1| 9| 3| 3| 1| 2| 7| 1| 3| 3| 0| 6| 8| 0| 7| 2| 8| 8| 2| 9| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 1 2 2 |
Hemorrhage | |
Mineralization | |
Ulcer | 3 1 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3|
Degeneration, Fatty | 2 2 1 |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 3 |
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 2 3 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 3 |
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 4| 4| 5| 4| 5| 5| 5| 4| 3| 5| 4| 4| 6| 3| 5| 4| 6| 5| 3| 4| 4|
DAY ON TEST | 8| 5| 8| 2| 6| 6| 0| 2| 4| 2| 8| 6| 9| 7| 0| 7| 6| 5| 2| 7| 0| 2| 5| 5| 4|
| 8| 2| 1| 8| 1| 9| 3| 3| 1| 2| 7| 1| 3| 3| 0| 6| 8| 0| 7| 2| 8| 8| 2| 9| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
C-Cell, Hyperplasia | 2 1 2 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Hyperplasia, Cystic | 1 1 2 2 1 1 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 3 3 3 3 3 2 2 3 4 3 3 3 2|
Myelofibrosis | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 4 4 2 3 2 |
Mediastinal, Hemorrhage | 4 4 3 3 3 3 3 4 2 2 3 4 |
Mediastinal, Pigmentation | 3 2 1 2 3 2 3 1 2 2 2 3 2 1|
Pancreatic, Hemorrhage | 3 2 |
Pancreatic, Pigmentation | 3 |
Renal, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +|
Congestion | 1 |
Hemorrhage | 1 2|
Pigmentation | 3|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 4| 4| 5| 4| 5| 5| 5| 4| 3| 5| 4| 4| 6| 3| 5| 4| 6| 5| 3| 4| 4|
DAY ON TEST | 8| 5| 8| 2| 6| 6| 0| 2| 4| 2| 8| 6| 9| 7| 0| 7| 6| 5| 2| 7| 0| 2| 5| 5| 4|
| 8| 2| 1| 8| 1| 9| 3| 3| 1| 2| 7| 1| 3| 3| 0| 6| 8| 0| 7| 2| 8| 8| 2| 9| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 4 |
Hematopoietic Cell Proliferation | 4 3 2 2 2 4 3 2 3 3 1 3 3 4 3 4|
Pigmentation | 3 2 3 2 2 3 2 3 3 3 3 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + I + + + +|
Hyperplasia | 1 2 2 3 3 3 4 2 3 1 1 2 1 2 2 2 2 2 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | 3 2 2 3 2 2 3 |
|__________________________________________________________________________|
Skeletal Muscle | + + + |
Hemorrhage | 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Hydrocephalus | 3 2 |
|__________________________________________________________________________|
Peripheral Nerve | + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 4 |
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 4| 4| 5| 4| 5| 5| 5| 4| 3| 5| 4| 4| 6| 3| 5| 4| 6| 5| 3| 4| 4|
DAY ON TEST | 8| 5| 8| 2| 6| 6| 0| 2| 4| 2| 8| 6| 9| 7| 0| 7| 6| 5| 2| 7| 0| 2| 5| 5| 4|
| 8| 2| 1| 8| 1| 9| 3| 3| 1| 2| 7| 1| 3| 3| 0| 6| 8| 0| 7| 2| 8| 8| 2| 9| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Hemorrhage | 3 3 2 4 4 2 2 1 3 4 |
Infiltration Cellular, Histiocyte | 3 3 1 3 1 1 4 4 1 2 2 1 2 2 1 1 2 1 1 3 2 1 |
Alveolar Epithelium, Hyperplasia | 3 2 3 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | 2 |
Respiratory Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 1 1 2 1 3 1 2 2 1 1 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Hyaline Droplet | 2 2 1 2 1 2 2 |
Renal Tubule, Mineralization | |
Renal Tubule, Necrosis | 3 |
Renal Tubule, Pigmentation | 1 1 2 1 1 1 2 1 2 2 2 2 2 1 2 1 |
Transitional Epithelium, Hyperplasia | 2 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 62
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 5| 5| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 4| 4| 5| 6| 4| 5| |
DAY ON TEST | 1| 9| 2| 0| 1| 7| 6| 5| 5| 4| 8| 2| 7| 4| 0| 7| 4| 6| 5| 0| 0| 5| 5| 3| 8| |
| 8| 1| 6| 6| 6| 0| 0| 2| 2| 2| 7| 8| 8| 0| 9| 5| 8| 9| 2| 7| 5| 6| 8| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + M + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | X X X X X X X X X X X | 20 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X X X X X | 13 |
Hematopoietic Cell Proliferation | 3 | 3 2.3|
Hemorrhage | 3 3 2 | 7 3.0|
Hepatodiaphragmatic Nodule | X X | 5 |
Infiltration Cellular, Mixed Cell | 3 2 | 3 2.0|
Mixed Cell Focus | X X X | 5 |
Necrosis, Focal | 3 3 2 2 3 3 4| 15 2.7|
Bile Duct, Hyperplasia | 1 2 1 2 2 1 | 10 1.7|
Hepatocyte, Cytomegaly | 2 2 2 3 3 2 2 2 2 2 3 3 2 2 2 2 2 | 29 2.3|
Hepatocyte, Hyperplasia, Regenerative| 4 4 3 4 4 3 4 4 3 4 2 4 2 3 4 4 4 4 3 3 3 4 4 4 4| 50 3.6|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 3 | 5 3.0|
Kupffer Cell, Pigmentation | 2 | 4 2.5|
|__________________________________________________________________________|____________|
Mesentery | + +| 5 |
Fat, Necrosis | 3| 3 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 5| 5| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 4| 4| 5| 6| 4| 5| |
DAY ON TEST | 1| 9| 2| 0| 1| 7| 6| 5| 5| 4| 8| 2| 7| 4| 0| 7| 4| 6| 5| 0| 0| 5| 5| 3| 8| |
| 8| 1| 6| 6| 6| 0| 0| 2| 2| 2| 7| 8| 8| 0| 9| 5| 8| 9| 2| 7| 5| 6| 8| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 1 | 4 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 2 3| 3 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 2 1 2 3 | 9 1.9|
Hemorrhage | 2 | 1 2.0|
Mineralization | 2 | 1 2.0|
Ulcer | 3 4 2 4| 7 2.9|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 | 6 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 | 7 3.0|
Degeneration, Fatty | | 3 1.7|
Hyperplasia, Focal | 1 2 | 3 1.7|
Hypertrophy, Focal | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 5| 5| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 4| 4| 5| 6| 4| 5| |
DAY ON TEST | 1| 9| 2| 0| 1| 7| 6| 5| 5| 4| 8| 2| 7| 4| 0| 7| 4| 6| 5| 0| 0| 5| 5| 3| 8| |
| 8| 1| 6| 6| 6| 0| 0| 2| 2| 2| 7| 8| 8| 0| 9| 5| 8| 9| 2| 7| 5| 6| 8| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 3 2 | 7 2.6|
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 | 19 3.0|
Pars Distalis, Hyperplasia, Focal | 3 3 | 6 2.7|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 2 3.0|
C-Cell, Hyperplasia | 1 2 3| 10 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 3 | 9 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 2 2 2 2 | 6 2.2|
Hyperplasia, Cystic | 2 2 | 9 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 3 2 2 2 3 2 3 2 3 2 3 2 3 3| 32 2.6|
Myelofibrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +| 40 |
Mediastinal, Congestion | 4 2 3 1 | 9 2.8|
Mediastinal, Hemorrhage | 4 2 3 3 3 2 4 3 2 2 3 3 4| 25 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 5| 5| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 4| 4| 5| 6| 4| 5| |
DAY ON TEST | 1| 9| 2| 0| 1| 7| 6| 5| 5| 4| 8| 2| 7| 4| 0| 7| 4| 6| 5| 0| 0| 5| 5| 3| 8| |
| 8| 1| 6| 6| 6| 0| 0| 2| 2| 2| 7| 8| 8| 0| 9| 5| 8| 9| 2| 7| 5| 6| 8| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Mediastinal, Pigmentation | 3 2 4 2 2 2 3 2 1 2 2 4 2 1 3 1 1 | 31 2.1|
Pancreatic, Hemorrhage | | 2 2.5|
Pancreatic, Pigmentation | | 1 3.0|
Renal, Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 1.0|
Hemorrhage | 2 2 1 3| 6 1.8|
Pigmentation | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 3 3 2 | 7 2.6|
Hematopoietic Cell Proliferation | 3 1 3 2 3 4 2 3 4 4 3 3 2 3 4 1 2 4| 34 2.9|
Pigmentation | 2 3 3 2 3 3 3 3 3 2 3 2 2 2 2 3 2| 29 2.6|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 2 2 2 2 2 3 3 2 1 4 2 1 3 1 2 2 3 3 2 3 2 3| 43 2.2|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Osteopetrosis | 2 2 | 9 2.3|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 6 |
Hemorrhage | 3 4 | 4 3.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 5| 5| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 4| 4| 5| 6| 4| 5| |
DAY ON TEST | 1| 9| 2| 0| 1| 7| 6| 5| 5| 4| 8| 2| 7| 4| 0| 7| 4| 6| 5| 0| 0| 5| 5| 3| 8| |
| 8| 1| 6| 6| 6| 0| 0| 2| 2| 2| 7| 8| 8| 0| 9| 5| 8| 9| 2| 7| 5| 6| 8| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 4 | 2 4.0|
Hydrocephalus | 3 | 3 2.7|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 5 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Edema | 3 | 2 3.5|
Hemorrhage | 3 2 1 2 2 3 1 3 3| 19 2.5|
Infiltration Cellular, Histiocyte | 3 1 1 2 2 1 1 1 1 1 3 2 1 1 1 4 1 1 3 3| 42 1.8|
Alveolar Epithelium, Hyperplasia | 3 3 | 7 2.3|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Inflammation, Chronic | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 2 | 3 1.3|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 2 1 1 2 3 1 1 1 1 1 1 1 2 1 2 1 | 28 1.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 5| 5| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 4| 4| 5| 6| 4| 5| |
DAY ON TEST | 1| 9| 2| 0| 1| 7| 6| 5| 5| 4| 8| 2| 7| 4| 0| 7| 4| 6| 5| 0| 0| 5| 5| 3| 8| |
| 8| 1| 6| 6| 6| 0| 0| 2| 2| 2| 7| 8| 8| 0| 9| 5| 8| 9| 2| 7| 5| 6| 8| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Hyaline Droplet | 1 2| 9 1.7|
Renal Tubule, Mineralization | 2 | 1 2.0|
Renal Tubule, Necrosis | 2 3 1 2 3| 6 2.3|
Renal Tubule, Pigmentation | 1 3 1 2 1 1 2| 23 1.5|
Transitional Epithelium, Hyperplasia | 2 1| 5 1.4|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Degeneration, Cystic | |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X X |
Infiltration Cellular, Mixed Cell | 2 1 2 1 2 |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 2 1 2 1 1 1 1 1 1 1 2 2 2 2 1 1 1 1 2 1 1 1 2 3|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 3 3 3 2 2 2 2 2 3|
|__________________________________________________________________________|
Mesentery | + + + + + + |
Accessory Spleen | X |
Fat, Necrosis | 3 3 3 4 4 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 1 1 |
Acinus, Cytoplasmic Alteration | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 1 1 2 2 3 2 2 2 2 2 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + M + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 |
Degeneration, Fatty | 1 1|
Hyperplasia, Focal | 1 |
Hypertrophy | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 |
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 3 3 3 3 |
__________________________________________|__________________________________________________________________________|
Page 70
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 3 2 3 3 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 2 2 2 3 2 1 2 2 2 2|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 1 |
Interstitial Cell, Hyperplasia | 1 2 2 2 3 2 2 1 2 2 1 2 2 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Mediastinal, Congestion | 1 2 2 |
Mediastinal, Hemorrhage | 2 2 |
Mediastinal, Hyperplasia | |
Mediastinal, Pigmentation | 2 2 1 1 1 2 1 1|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2|
Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 3 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 2 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X|
Hemorrhage | |
Inflammation, Chronic | 1 3 1|
Respiratory Epithelium, Hyperplasia | 1 3 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Hyaline Droplet | |
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 73
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + I + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X | 32 |
Clear Cell Focus | X | 3 |
Degeneration, Cystic | 1 | 1 1.0|
Eosinophilic Focus | X | 3 |
Hepatodiaphragmatic Nodule | X | 4 |
Infiltration Cellular, Mixed Cell | 2 1 2 | 8 1.6|
Mixed Cell Focus | X X | 3 |
Bile Duct, Hyperplasia | 2 1 1 2 2 1 2 1 2 2 2 1 1 2 1 2 1 1 1 1 1 1 1 1| 48 1.4|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 3 3 2 3 2 2 3 1 1 1 3 3 3 2 3| 30 2.5|
|__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Accessory Spleen | | 1 |
Fat, Necrosis | 3 4 | 7 3.4|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 | 7 1.7|
Acinus, Cytoplasmic Alteration | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 1 1 1 1 2 2 1 3 1 1 1| 32 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 3 3 3 | 8 3.0|
Degeneration, Fatty | 1 3 3 | 5 1.8|
Hyperplasia, Focal | 1 2 | 3 1.3|
Hypertrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + M + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 3 3 3 | 4 3.0|
Pars Distalis, Hyperplasia, Focal | 2 | 5 1.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 | 4 1.5|
Follicle, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 2 2 3 3 2 | 9 2.7|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 3 2 2 2 2 2 2 2 3 | 24 2.2|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 2 2 2 | 18 1.8|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 3 3.0|
Interstitial Cell, Hyperplasia | 1 1 2 2 2 2 2 | 22 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + +| 13 |
Mediastinal, Congestion | | 3 1.7|
Mediastinal, Hemorrhage | 3 | 3 2.3|
Mediastinal, Hyperplasia | 2 | 1 2.0|
Mediastinal, Pigmentation | 1 2| 10 1.4|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 2.0|
Pigmentation | 2| 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + I + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + M M + M + M + + + + M + + M + + + +| 42 |
Cyst | 3 | 1 3.0|
Hyperplasia | 2 2 | 5 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis | 4 | 1 4.0|
Subcutaneous Tissue, Fibrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 | 2 3.0|
Hydrocephalus | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9| |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 42 1.0|
Metaplasia, Osseous | 1 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 3 1.3|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 5 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | 1 2 3 2 | 7 1.9|
Respiratory Epithelium, Hyperplasia | 2 1 3 | 7 1.7|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.0|
Renal Tubule, Hyaline Droplet | 3 | 1 3.0|
Renal Tubule, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 3| 4| 4| 4| 3| 4| 2| 4| 4| 4| 3| 4| 3| 4|
DAY ON TEST | 8| 9| 1| 9| 0| 9| 0| 5| 3| 1| 9| 0| 2| 7| 1| 2| 4| 0| 8| 1| 6| 7| 0| 4| 1|
| 8| 7| 5| 7| 3| 7| 2| 7| 3| 4| 7| 7| 2| 7| 4| 7| 6| 4| 3| 9| 3| 3| 8| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Edema | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Necrosis | 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | A + A + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + A + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | X |
Degeneration, Cystic | 2 |
Eosinophilic Focus | X X X X X X X |
Hematopoietic Cell Proliferation | |
Hemorrhage | 4 3 |
Hepatodiaphragmatic Nodule | X X |
Metaplasia, Osseous | |
Mixed Cell Focus | X X X X X |
Necrosis, Focal | 4 4 4 2 4 3 4 1 4 4 2|
Bile Duct, Hyperplasia | 2 3 2 3 2 2 2 2 3 2 2 1 2 2 2 2|
Hepatocyte, Cytomegaly | 2 2 2 2 3 3 2 3 3 2 2 3 2|
Hepatocyte, Hyperplasia, Atypical | 4 |
Hepatocyte, Hyperplasia, Regenerative| 3 4 4 4 4 3 3 4 3 3 4 4 4 3 4 4 X 3 4 4 4 4 3 3|
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Kupffer Cell, Pigmentation | 3 |
|__________________________________________________________________________|
Mesentery | + + + + |
__________________________________________|__________________________________________________________________________|
Page 79
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 3| 4| 4| 4| 3| 4| 2| 4| 4| 4| 3| 4| 3| 4|
DAY ON TEST | 8| 9| 1| 9| 0| 9| 0| 5| 3| 1| 9| 0| 2| 7| 1| 2| 4| 0| 8| 1| 6| 7| 0| 4| 1|
| 8| 7| 5| 7| 3| 7| 2| 7| 3| 4| 7| 7| 2| 7| 4| 7| 6| 4| 3| 9| 3| 3| 8| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Accessory Spleen | |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 1 |
Acinus, Hyperplasia, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Necrosis | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Ulcer | 3 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 2 3 3 3 |
Hemorrhage | 3 |
Ulcer | 3 2 4 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 3 1 1 2 3 2 1 3 2 1 2 |
Myocardium, Hemorrhage | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 |
Degeneration, Fatty | 2 1 |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | |
Necrosis | 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 3| 4| 4| 4| 3| 4| 2| 4| 4| 4| 3| 4| 3| 4|
DAY ON TEST | 8| 9| 1| 9| 0| 9| 0| 5| 3| 1| 9| 0| 2| 7| 1| 2| 4| 0| 8| 1| 6| 7| 0| 4| 1|
| 8| 7| 5| 7| 3| 7| 2| 7| 3| 4| 7| 7| 2| 7| 4| 7| 6| 4| 3| 9| 3| 3| 8| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 3 |
Pars Distalis, Hyperplasia, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 3 3 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 2 3 1 2|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
Interstitial Cell, Hyperplasia | 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 3 3 2 2 3 3 3 3 3 3 3 2 4 3 4 4|
Myelofibrosis | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 3| 4| 4| 4| 3| 4| 2| 4| 4| 4| 3| 4| 3| 4|
DAY ON TEST | 8| 9| 1| 9| 0| 9| 0| 5| 3| 1| 9| 0| 2| 7| 1| 2| 4| 0| 8| 1| 6| 7| 0| 4| 1|
| 8| 7| 5| 7| 3| 7| 2| 7| 3| 4| 7| 7| 2| 7| 4| 7| 6| 4| 3| 9| 3| 3| 8| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Bronchial, Hemorrhage | |
Bronchial, Pigmentation | |
Iliac, Necrosis | |
Mediastinal, Congestion | 2 3 3 3 4 3 |
Mediastinal, Hemorrhage | 4 4 3 3 4 4 4 4 4 |
Mediastinal, Necrosis | |
Mediastinal, Pigmentation | 3 3 2 2 3 2 1 3 3 3 |
Pancreatic, Hemorrhage | 4 |
Pancreatic, Pigmentation | 3 |
Renal, Hemorrhage | |
Renal, Necrosis | |
Renal, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Hemorrhage | 2 2 2 3 2 2 |
Pigmentation | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 3 3 3 2 2 4 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 3 3 2 2 2 2 3 3 3 3|
Hyperplasia, Reticulum Cell | 3 |
Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + M M + + M + + + + + + + + + + + M|
Cyst | |
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 3| 4| 4| 4| 3| 4| 2| 4| 4| 4| 3| 4| 3| 4|
DAY ON TEST | 8| 9| 1| 9| 0| 9| 0| 5| 3| 1| 9| 0| 2| 7| 1| 2| 4| 0| 8| 1| 6| 7| 0| 4| 1|
| 8| 7| 5| 7| 3| 7| 2| 7| 3| 4| 7| 7| 2| 7| 4| 7| 6| 4| 3| 9| 3| 3| 8| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Hyperplasia | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | |
|__________________________________________________________________________|
Skeletal Muscle | + + + + |
Hemorrhage | 2 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + |
|__________________________________________________________________________|
Spinal Cord | + + + |
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 3 |
Hemorrhage | 2 3 2 2 4 3 4 2 4 3|
Infiltration Cellular, | |
Polymorphonuclear | 1 |
Infiltration Cellular, Histiocyte | 2 3 1 3 2 1 3 3 4 3 2 4 2 2 3|
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Hemorrhage | |
Inflammation, Chronic | 1 1 4 |
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 3| 4| 4| 4| 3| 4| 2| 4| 4| 4| 3| 4| 3| 4|
DAY ON TEST | 8| 9| 1| 9| 0| 9| 0| 5| 3| 1| 9| 0| 2| 7| 1| 2| 4| 0| 8| 1| 6| 7| 0| 4| 1|
| 8| 7| 5| 7| 3| 7| 2| 7| 3| 4| 7| 7| 2| 7| 4| 7| 6| 4| 3| 9| 3| 3| 8| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Respiratory Epithelium, Hyperplasia | 2 1 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Hydronephrosis | 2 |
Infarct | 3 |
Inflammation, Suppurative | 2 |
Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1|
Renal Tubule, Hyaline Droplet | 2 2 |
Renal Tubule, Necrosis | 1 2 3 |
Renal Tubule, Pigmentation | 1 3 2 |
Transitional Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 84
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 4| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| |
DAY ON TEST | 1| 4| 1| 6| 3| 2| 1| 0| 4| 0| 7| 9| 1| 6| 4| 0| 0| 2| 9| 6| 1| 1| 9| 0| 7| |
| 0| 9| 4| 6| 7| 1| 8| 0| 0| 0| 3| 7| 2| 2| 0| 7| 2| 4| 8| 4| 5| 1| 7| 7| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perforation | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + I + + + + I + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 2 | 3 2.3|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X | 21 |
Clear Cell Focus | X X X X | 5 |
Degeneration, Cystic | 2 2 | 3 2.0|
Eosinophilic Focus | X X X X X X X X | 15 |
Hematopoietic Cell Proliferation | 3 3 | 2 3.0|
Hemorrhage | 4 3 | 4 3.5|
Hepatodiaphragmatic Nodule | X X | 4 |
Metaplasia, Osseous | 2 | 1 2.0|
Mixed Cell Focus | X X | 7 |
Necrosis, Focal | 4 4 3 3 2 4 3 2 4 4 2 3 | 23 3.2|
Bile Duct, Hyperplasia | 3 2 3 3 2 2 2 2 2 2 2 3 1 2 2 2 3 2 1 2 2| 37 2.1|
Hepatocyte, Cytomegaly | 2 2 4 2 3 3 2 2 3 2 2 2 3 2 2 2 2 2 2| 32 2.3|
Hepatocyte, Hyperplasia, Atypical | | 1 4.0|
Hepatocyte, Hyperplasia, Regenerative| 4 4 3 3 4 4 3 4 3 3 4 3 4 3 3 4 4 4 4 3 3 3 4 4 3| 49 3.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 4| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| |
DAY ON TEST | 1| 4| 1| 6| 3| 2| 1| 0| 4| 0| 7| 9| 1| 6| 4| 0| 0| 2| 9| 6| 1| 1| 9| 0| 7| |
| 0| 9| 4| 6| 7| 1| 8| 0| 0| 0| 3| 7| 2| 2| 0| 7| 2| 4| 8| 4| 5| 1| 7| 7| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 3 | 5 2.0|
Kupffer Cell, Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Accessory Spleen | X | 1 |
Fat, Necrosis | 4 4 | 3 3.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 2 | 7 1.4|
Acinus, Hyperplasia, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Necrosis | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 2 2.5|
Ulcer | 3 | 3 3.3|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 3 2 2 1 3 | 10 2.5|
Hemorrhage | | 1 3.0|
Ulcer | 3 2 | 6 2.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 2 1 3 3 2 2 1 2 1 1 2| 28 1.8|
Myocardium, Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 4| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| |
DAY ON TEST | 1| 4| 1| 6| 3| 2| 1| 0| 4| 0| 7| 9| 1| 6| 4| 0| 0| 2| 9| 6| 1| 1| 9| 0| 7| |
| 0| 9| 4| 6| 7| 1| 8| 0| 0| 0| 3| 7| 2| 2| 0| 7| 2| 4| 8| 4| 5| 1| 7| 7| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Degeneration, Fatty | 2 1 | 4 1.5|
Hyperplasia, Diffuse | 2 | 1 2.0|
Hyperplasia, Focal | 1 | 1 1.0|
Necrosis | | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | | 2 3.0|
Pars Distalis, Hyperplasia, Focal | 2 2 1 1| 4 1.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 3 | 1 3.0|
C-Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 2 2 2 3 3 | 9 2.4|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 1 2 2 2 2 2 2 2 2 | 16 1.9|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 2 3 3 4 2 3 | 15 2.4|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 4| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| |
DAY ON TEST | 1| 4| 1| 6| 3| 2| 1| 0| 4| 0| 7| 9| 1| 6| 4| 0| 0| 2| 9| 6| 1| 1| 9| 0| 7| |
| 0| 9| 4| 6| 7| 1| 8| 0| 0| 0| 3| 7| 2| 2| 0| 7| 2| 4| 8| 4| 5| 1| 7| 7| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 1 | 6 2.0|
Interstitial Cell, Hyperplasia | 1 1 2 2 1 2 2 | 12 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 3 4 2 2 4 3 3 3 4 4 2 2 3 4 3 2 2 | 36 3.0|
Myelofibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + | 39 |
Bronchial, Hemorrhage | 3 | 1 3.0|
Bronchial, Pigmentation | 3 | 1 3.0|
Iliac, Necrosis | 3 | 1 3.0|
Mediastinal, Congestion | 4 3 4 4 4 | 11 3.4|
Mediastinal, Hemorrhage | 4 3 3 4 3 4 4 2 4 4 3 | 20 3.6|
Mediastinal, Necrosis | 3 | 1 3.0|
Mediastinal, Pigmentation | 2 3 3 4 3 3 3 3 3 3 | 20 2.8|
Pancreatic, Hemorrhage | 4 | 2 4.0|
Pancreatic, Pigmentation | 3 | 2 3.0|
Renal, Hemorrhage | 4 2 3 | 3 3.0|
Renal, Necrosis | 2 | 1 2.0|
Renal, Pigmentation | 4 3 3 | 3 3.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 1 1 | 4 1.3|
Hemorrhage | 2 3 | 8 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 4| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| |
DAY ON TEST | 1| 4| 1| 6| 3| 2| 1| 0| 4| 0| 7| 9| 1| 6| 4| 0| 0| 2| 9| 6| 1| 1| 9| 0| 7| |
| 0| 9| 4| 6| 7| 1| 8| 0| 0| 0| 3| 7| 2| 2| 0| 7| 2| 4| 8| 4| 5| 1| 7| 7| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 3 3 3 2 3 3 2 3 3 3 2 3 3 2 3| 24 2.7|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 4 2 4 4 3 2 3 4 4 | 23 2.8|
Hyperplasia, Reticulum Cell | | 1 3.0|
Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Hemorrhage | 3 2 2 3| 4 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + M + + + M + + + + + M M + + + M M + + M M + +| 38 |
Cyst | 3 | 1 3.0|
Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Osteopetrosis | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 5 |
Hemorrhage | | 3 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 4| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| |
DAY ON TEST | 1| 4| 1| 6| 3| 2| 1| 0| 4| 0| 7| 9| 1| 6| 4| 0| 0| 2| 9| 6| 1| 1| 9| 0| 7| |
| 0| 9| 4| 6| 7| 1| 8| 0| 0| 0| 3| 7| 2| 2| 0| 7| 2| 4| 8| 4| 5| 1| 7| 7| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 5 |
Hemorrhage | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 4 4 | 5 3.2|
Hemorrhage | 4 3 2 4 4 3 2 4 4 4 3 | 21 3.1|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 1.0|
Infiltration Cellular, Histiocyte | 2 4 1 3 3 4 1 3 4 1 4 4 1 4 3 1 1 | 32 2.6|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X X | 5 |
Hemorrhage | 3 3 | 2 3.0|
Inflammation, Chronic | 3 2 | 5 2.2|
Respiratory Epithelium, Hyperplasia | 2 2 1 | 6 1.7|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glomerulosclerosis | 2 | 1 2.0|
Hydronephrosis | 3 | 2 2.5|
Infarct | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05161-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 12/15/00
Route: GAVAGE Time: 12:10:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 4| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| |
DAY ON TEST | 1| 4| 1| 6| 3| 2| 1| 0| 4| 0| 7| 9| 1| 6| 4| 0| 0| 2| 9| 6| 1| 1| 9| 0| 7| |
| 0| 9| 4| 6| 7| 1| 8| 0| 0| 0| 3| 7| 2| 2| 0| 7| 2| 4| 8| 4| 5| 1| 7| 7| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Inflammation, Suppurative | | 1 2.0|
Nephropathy | 1 1 2 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 2 1 | 38 1.2|
Renal Tubule, Hyaline Droplet | 1 | 3 1.7|
Renal Tubule, Necrosis | 3 2 2 | 6 2.2|
Renal Tubule, Pigmentation | 3 | 4 2.3|
Transitional Epithelium, Hyperplasia | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
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