TDMS Study 05161-06 Pathology Tables
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
FINAL#2
Facility: Southern Research Institute
Chemical CAS #: 23246-96-0
Lock Date: 11/17/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 6| 7| 7| 4| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 3| 3| 9| 5| 3| 3| 1| 2| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3|
| 4| 5| 5| 5| 5| 6| 7| 5| 5| 9| 7| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + A + + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + A + + + + + + + + + + +|
Fibrosis | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + A A + + + + + + + + + +|
Epithelium, Cyst | |
|__________________________________________________________________________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hyperplasia, Focal, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | 1 2 2 1 1 1 3 2 1 1 2 2 |
Inflammation, Focal, Suppurative | |
Mineralization, Focal | |
Hepatocyte, Mixed Cell Focus | 2|
Hepatocyte, Necrosis, Focal | 1 1 1 2 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Diffuse | 3 3 3 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 1 2 |
Hepatocyte, Midzonal, Vacuolization | |
Cytoplasmic | |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 6| 7| 7| 4| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 3| 3| 9| 5| 3| 3| 1| 2| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3|
| 4| 5| 5| 5| 5| 6| 7| 5| 5| 9| 7| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Artery, Inflammation, Chronic, Focal | |
Fat, Necrosis | 2 2 1 3 2 2 3 2 3|
|__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Atrophy, Focal | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
|__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 3 |
Ulcer | 2 |
Epithelium, Cyst | |
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + |
Malformation | 2 |
Peridontal Tissue, Inflammation, | |
Chronic | 1 2 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Cytoplasmic Alteration, Focal | |
Bilateral, Hypertrophy, Focal | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +|
Atypia Cellular | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 6| 7| 7| 4| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 3| 3| 9| 5| 3| 3| 1| 2| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3|
| 4| 5| 5| 5| 5| 6| 7| 5| 5| 9| 7| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + I + + + + + + + +|
Angiectasis | 3 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
Rathke's Cleft, Cyst | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 3 2 2 1 3 2 2|
Inflammation, Chronic, Focal | 1 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Ovary | + A + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 2 3 3 3 1 3 3 |
Hemorrhage | 2 |
Mineralization | 1 |
Pigmentation, Focal | 2 |
Bilateral, Cyst | |
Interstitial Cell, Hyperplasia | 3 |
|__________________________________________________________________________|
Uterus | + A + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 3 3 3 3 2 3 3 3 4 3 3|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 6| 7| 7| 4| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 3| 3| 9| 5| 3| 3| 1| 2| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3|
| 4| 5| 5| 5| 5| 6| 7| 5| 5| 9| 7| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Inflammation, Suppurative | 3 2 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 1 2 3 3 3 3 4 3 3 3 3 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
|__________________________________________________________________________|
Lymph Node | + + + + |
Hyperplasia, Lymphoid | 2 |
Iliac, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
Hyperplasia, Plasma Cell | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | |
|__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 4 2 2 3 4 2 3 2 4 2 2 3 3 3|
Hyperplasia, Lymphoid | 2 2 3 2|
Hyperplasia, Plasma Cell | |
Pigmentation | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia, Lymphoid | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Subcutaneous Tissue, Inflammation, | |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 6| 7| 7| 4| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 3| 3| 9| 5| 3| 3| 1| 2| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3|
| 4| 5| 5| 5| 5| 6| 7| 5| 5| 9| 7| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Focal, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Hyperostosis, Focal | 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 2|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 1 |
Foreign Body | |
Hemorrhage | 2 |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation, Focal | |
Alveolar Epithelium, Hyperplasia | 1 |
Interstitium, Edema | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Atrophy | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 6| 7| 7| 4| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 3| 3| 9| 5| 3| 3| 1| 2| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3|
| 4| 5| 5| 5| 5| 6| 7| 5| 5| 9| 7| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | 2 2 |
Metaplasia, Focal, Osseous | |
Mineralization, Focal | 3 |
Nephropathy | 1 1 1 1 1 1 2 3 1 3 1|
Artery, Inflammation, Chronic | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 2 |
Renal Tubule, Casts Protein | 2 |
Renal Tubule, Dilatation | 1 1 |
Renal Tubule, Hemorrhage | 2 |
Renal Tubule, Necrosis | 2 |
Renal Tubule, Pigmentation | 1 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + M + + + + + + A A + + + + + + + + + + + + + + +| 45 |
Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + M A + A + + + + M + + + + + + + + + M| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +| 46 |
Epithelium, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 2 | 2 2.0|
Clear Cell Focus | | 1 |
Eosinophilic Focus | X | 2 |
Hyperplasia, Focal, Lymphoid | 2 | 2 2.0|
Infiltration Cellular, Mixed Cell | 3 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1| 29 1.4|
Inflammation, Focal, Suppurative | 2 | 1 2.0|
Mineralization, Focal | 1| 1 1.0|
Hepatocyte, Mixed Cell Focus | | 1 2.0|
Hepatocyte, Necrosis, Focal | 2 1 1 1 2 1 1 1 | 12 1.3|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | 3 3 3 3 3 | 8 3.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 | 3 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Midzonal, Vacuolization | | |
Cytoplasmic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + | 23 |
Artery, Inflammation, Chronic, Focal | 3 | 1 3.0|
Fat, Necrosis | 3 1 1 3 2 3 3 3 4 4 | 19 2.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | | 1 3.0|
Atrophy, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Focal | 1 | 2 2.0|
Ulcer | | 1 2.0|
Epithelium, Cyst | 1 | 1 1.0|
Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Tooth | + + | 7 |
Malformation | | 1 2.0|
Peridontal Tissue, Inflammation, | | |
Chronic | 1 2 | 6 1.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | 2 1 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 1.0|
Cytoplasmic Alteration, Focal | 1 | 1 1.0|
Bilateral, Hypertrophy, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atypia Cellular | | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + M + + + +| 47 |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 3 2 | 4 2.5|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 2 2 | 3 2.0|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
Rathke's Cleft, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + I + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic, Focal | 2 1 1 1 2 2 | 13 1.8|
Inflammation, Chronic, Focal | | 1 1.0|
Follicle, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 2 | 3 2.7|
Cyst | 3 3 3 3 3 3 1 2 | 15 2.6|
Hemorrhage | | 1 2.0|
Mineralization | | 1 1.0|
Pigmentation, Focal | | 1 2.0|
Bilateral, Cyst | 3 | 1 3.0|
Interstitial Cell, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 | 1 3.0|
Hydrometra | 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3 3| 27 3.0|
Inflammation, Suppurative | | 2 2.5|
Endometrium, Hyperplasia, Cystic | 3 3 3 3 2 3 3 3 3 3 3 3 3 2 3 3 3 3 3 2 3 3| 43 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 3.5|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Hyperplasia, Lymphoid | | 1 2.0|
Iliac, Hemorrhage | 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + M + + + + + + + +| 48 |
Hyperplasia, Lymphoid | | 2 3.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + I + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia, Plasma Cell | 4 2 3 | 3 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hematopoietic Cell Proliferation | 3 2 3 2 3 3 2 2 2 2 2 2 2 4 2 2| 32 2.6|
Hyperplasia, Lymphoid | 3 2 2 3 3 | 9 2.4|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vertebra, Hyperostosis, Focal | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 41 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 1 | 3 1.3|
Foreign Body | 3 2 3 2 | 4 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Hemorrhage | | 1 2.0|
Hyperplasia, Histiocytic | 2 | 2 2.5|
Hyperplasia, Lymphoid | | 2 2.0|
Pigmentation, Focal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Interstitium, Edema | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 4 | 1 4.0|
Inflammation, Chronic | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Cyst | 2 | 3 2.0|
Metaplasia, Focal, Osseous | 1 | 1 1.0|
Mineralization, Focal | | 1 3.0|
Nephropathy | 1 1 1 1 1 1 1 | 18 1.3|
Artery, Inflammation, Chronic | 4 | 1 4.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 2 2.5|
Renal Tubule, Casts Protein | 2 | 2 2.0|
Renal Tubule, Dilatation | | 2 1.0|
Renal Tubule, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 3| 3| 3| 8| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 7| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Renal Tubule, Necrosis | | 1 2.0|
Renal Tubule, Pigmentation | | 2 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|
DAY ON TEST | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|
| 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + A + + + + A + + + + + + M + + + + + + + +|
Cyst | |
Epithelium, Cytoplasmic Alteration | 3 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage, Focal | 3 |
Artery, Inflammation, Chronic, Focal | 1 2 2 2 2 1 1 2 2|
Epithelium, Erosion, Focal | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Necrosis, Focal | |
Artery, Inflammation, Chronic | 1 2 2 2 2 1 1 2|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion, Focal | 2 |
Cyst | 2 |
Fibrosis, Focal | |
Hemorrhage, Focal | 3 2 |
Infarct | 3 |
Infiltration Cellular, Mixed Cell | 2 3 1 2 2 2 2 2 1 2 2 1 2 2 2 2 2 2 2 2 1 2|
Pigmentation, Focal | 2 |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|
DAY ON TEST | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|
| 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Thrombosis | 2 |
Artery, Inflammation, Chronic | 1 |
Bile Duct, Hyperplasia | 2 2 1 2 1 2 1 2 2 2 2 2 3 2 |
Endothelial Cell, Hyperplasia, Focal | |
Hepatocyte, Cytomegaly | 3 3 3 2 3 3 2 3 1 1 3 3 2 2 3 2 3 2 2 1 2 3 3 3|
Hepatocyte, Karyomegaly | 3 3 3 2 3 3 2 3 1 1 3 3 2 2 3 2 3 2 2 1 2 3 3 3|
Hepatocyte, Necrosis, Focal | 2 1 1 2 1 1 1 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Diffuse | 3 |
Hepatocyte, Centrilobular, Necrosis | 3 |
Hepatocyte, Centrilobular, | |
Vacuolization Cytoplasmic | 3 3 2 |
Hepatocyte, Midzonal, Vacuolization | |
Cytoplasmic | 2 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hemorrhage | |
Inflammation, Chronic, Focal, | |
Suppurative | |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
Artery, Inflammation, Chronic, Focal | 2 3 3 3 2 2 2 3 2 2 3|
Artery, Mineralization, Focal | |
Fat, Necrosis | 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Necrosis, Focal | |
Acinus, Atrophy, Diffuse | 4 |
Acinus, Atrophy, Focal | |
Artery, Inflammation, Chronic | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|
DAY ON TEST | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|
| 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic | |
Aorta, Mineralization | 3 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 1 |
Inflammation, Chronic, Focal | 2|
Mineralization, Focal | 3 2 2 |
Epicardium, Infiltration Cellular, | |
Mixed Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | |
Cytoplasmic Alteration, Focal | 2 2 2 1 1 3 3 2 2 4 2 3 2|
Cytoplasmic Alteration | |
Inflammation, Chronic, Focal | 2 3 2 2|
Thrombosis | |
Capsule, Fibrosis, Focal | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + I + + + + + + + + + + + + + M + + + +|
Cyst | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Cytoplasmic | |
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|
DAY ON TEST | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|
| 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Alteration, Focal | 1 |
Pars Distalis, Hemorrhage, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 3 3 1 2 3 2 1 1 3|
Inflammation, Chronic, Focal | 2 1 |
Follicular Cell, Cytoplasmic | |
Alteration, Diffuse | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 |
|__________________________________________________________________________|
Ovary | + I + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 2 3 2 2 2 3|
Cyst, Multiple | |
Hemorrhage | 3 |
Inflammation, Suppurative | |
Thrombosis | 2 |
Artery, Inflammation, Chronic | 2 3 1 3 3 2 3 2 2 3 3 3 3|
Bilateral, Cyst | 2 3 |
Interstitial Cell, Hyperplasia | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Hemorrhage | |
Hydrometra | 3 2 2 3 2 2 3 3 3 3 3|
Artery, Inflammation, Chronic, Focal | 1 3 3 2 2 3 2 2 2 2 |
Artery, Inflammation | 3 |
Endometrium, Hyperplasia, Cystic | 3 2 2 3 3 3 3 2 3 2 3 3 3 3 3 3 3 3 3 3 3 3|
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|
DAY ON TEST | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|
| 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Hemorrhage | |
Hyperplasia, Histiocytic | |
Bronchial, Hyperplasia, Lymphoid | 2 |
Bronchial, Hyperplasia, Plasma Cell | 3 |
Deep Cervical, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Plasma Cell | 4 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Renal, Angiectasis | 4 |
Renal, Hemorrhage | 4 4 |
Renal, Hyperplasia, Plasma Cell | 4 |
Renal, Inflammation, Suppurative | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 3 2 |
Hemorrhage | 2 3 3 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 |
Artery, Inflammation, Chronic | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|
DAY ON TEST | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|
| 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 3 4 3 4 3 3 3 3 2 3 3 2 3 3 3 3 3 3 3 3 4 3|
Hyperplasia, Lymphoid | 3 |
Artery, Inflammation, Chronic, Focal | 3 |
|__________________________________________________________________________|
Thymus | + + + + I + + + + + + I + + + + + M M + + M + I +|
Atrophy | 3 |
Cyst | 2 |
Hyperplasia, Histiocytic | 3 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Subcutaneous Tissue, | |
Inflammation, Chronic | 2|
Dermis, Edema, Focal | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | 2 |
Vertebra, Hyperostosis, Focal | 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Gliosis | 1 |
Hemorrhage, Focal | 2 |
Artery, Meninges, Inflammation, | |
Chronic | |
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|
DAY ON TEST | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|
| 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Peripheral Nerve | + |
Spinal, Ganglion, Inflammation, | |
Chronic | |
|__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage, Focal | |
Meninges, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 |
Hyperplasia, Focal, Mast Cell | |
Hyperplasia, Histiocytic | 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 |
Alveolar Epithelium, Hyperplasia | 1 2 |
Artery, Mediastinum, Inflammation, | |
Chronic | 2 |
Mediastinum, Inflammation, Chronic | |
Mediastinum, Inflammation, | |
Suppurative | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | |
|__________________________________________________________________________|
Pleura | |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Atrophy | |
|__________________________________________________________________________|
Harderian Gland | + |
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 7|
DAY ON TEST | 3| 0| 3| 7| 3| 6| 0| 2| 3| 1| 2| 2| 0| 2| 9| 9| 1| 0| 2| 5| 3| 6| 9| 9| 3|
| 5| 4| 5| 5| 0| 9| 0| 0| 0| 6| 9| 9| 9| 9| 6| 2| 8| 9| 2| 6| 5| 0| 6| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
Metaplasia, Focal, Osseous | 2 1 2 1 2 |
Mineralization, Focal | 3 |
Nephropathy | 3 3 4 3 2 4 4 3 4 2 3 3 2 4 4 4 4 4 4 4 4 4 2 3|
Artery, Inflammation, Chronic | 3 3 2 2|
Artery, Mineralization | 1 |
Glomerulus, Glomerulosclerosis | 3 2 3 2 3 2 2 3 1 3 3 3 4 3 3 3 2 3 3|
Pelvis, Dilatation | 3 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 2 |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Karyomegaly | 2 |
Renal Tubule, Pigmentation | 3 1 3 2 2 3 3 3 3 2 3 3 3 2|
|__________________________________________________________________________|
Ureter | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 3|
__________________________________________|__________________________________________________________________________
Page 22
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4| |
DAY ON TEST | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3| |
| 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + + + + + + + + + + + + + + A + + +| 45 |
Cyst | 2 1 | 2 1.5|
Epithelium, Cytoplasmic Alteration | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + A + + + + + + + + + + + + + A + + +| 47 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + A + + + + + + + + + + + + + A + + +| 47 |
Inflammation, Chronic, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + A + + + + + + + + + + + + + A + + +| 47 |
Edema | 3 3 3 3 3 | 5 3.0|
Hemorrhage, Focal | 3 2 2 2 2 | 6 2.3|
Artery, Inflammation, Chronic, Focal | 2 2 1 2 2 1 2 2 2 | 18 1.7|
Epithelium, Erosion, Focal | 2 1 3 2 1 | 6 1.8|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + A + + + + A + + + + + + + + A + + +| 46 |
Hemorrhage, Focal | 3 2 | 2 2.5|
Necrosis, Focal | 4 2 | 2 3.0|
Artery, Inflammation, Chronic | 2 2 2 3 3 | 13 1.9|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + A + + + + A + + + + + A + + A + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + A + + + + A + + + + + + + + A + + +| 46 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Congestion, Focal | | 1 2.0|
Cyst | | 1 2.0|
Fibrosis, Focal | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4| |
DAY ON TEST | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3| |
| 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hemorrhage, Focal | | 2 2.5|
Infarct | | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 2 2 2 1 2 2 2 2 1 2 1 1 2 2 1 1 3 2| 41 1.8|
Pigmentation, Focal | | 1 2.0|
Thrombosis | | 1 2.0|
Artery, Inflammation, Chronic | | 1 1.0|
Bile Duct, Hyperplasia | 2 2 2 1 3 2 2 2 1 2 3 2 2 2 | 28 1.9|
Endothelial Cell, Hyperplasia, Focal | 3 | 1 3.0|
Hepatocyte, Cytomegaly | 2 3 2 2 2 3 2 2 2 3 3 1 2 1 3 2 3 2 2 2 2 2 1 3 1| 49 2.3|
Hepatocyte, Karyomegaly | 2 3 2 2 2 3 2 2 2 3 3 1 2 1 3 2 3 2 2 2 2 2 1 3 1| 49 2.3|
Hepatocyte, Necrosis, Focal | 4 1 1 2 1 2 2 2 1 1 1 2 | 19 1.5|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | | 1 3.0|
Hepatocyte, Centrilobular, Necrosis | | 1 3.0|
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | | 3 2.7|
Hepatocyte, Midzonal, Vacuolization | | |
Cytoplasmic | 2 | 3 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + +| 29 |
Fibrosis, Focal | 3 3 | 2 3.0|
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic, Focal, | | |
Suppurative | 2 | 1 2.0|
Inflammation, Chronic | 2 | 2 2.5|
Inflammation, Suppurative | 4 | 1 4.0|
Artery, Inflammation, Chronic, Focal | 3 3 2 2 2 2 3 4| 19 2.5|
Artery, Mineralization, Focal | 2 | 1 2.0|
Fat, Necrosis | | 2 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 3 | 1 3.0|
Necrosis, Focal | 2 | 1 2.0|
Acinus, Atrophy, Diffuse | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4| |
DAY ON TEST | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3| |
| 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Acinus, Atrophy, Focal | 1 | 1 1.0|
Artery, Inflammation, Chronic | 1 1 2 | 3 1.3|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + A + + +| 48 |
Cyst | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | +| 2 |
Inflammation, Chronic | 3| 1 3.0|
Aorta, Mineralization | | 1 3.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | 2 2 2 1 2 | 6 1.7|
Inflammation, Chronic, Focal | 2 | 2 2.0|
Mineralization, Focal | 2 | 4 2.3|
Epicardium, Infiltration Cellular, | | |
Mixed Cell | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 2 1.0|
Angiectasis | 4 | 1 4.0|
Cytoplasmic Alteration, Focal | 1 2 1 2 2 3 1 2 2 3 1 X | 25 2.0|
Cytoplasmic Alteration | 2 | 1 2.0|
Inflammation, Chronic, Focal | 3 1 | 6 2.2|
Thrombosis | 3 | 1 3.0|
Capsule, Fibrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4| |
DAY ON TEST | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3| |
| 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + I + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + M + + +| 46 |
Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 2 1 | 3 1.3|
Pars Distalis, Hemorrhage, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 2 1 1 2 1 1 1 3 2 2| 21 1.9|
Inflammation, Chronic, Focal | | 2 1.5|
Follicular Cell, Cytoplasmic | | |
Alteration, Diffuse | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Abdominal, Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + I + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | | 2 2.5|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + I + + +| 48 |
Angiectasis | 3 | 1 3.0|
Cyst | 3 2 2 3 3 2 3 4| 15 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4| |
DAY ON TEST | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3| |
| 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Cyst, Multiple | 3 2 | 2 2.5|
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
Thrombosis | | 1 2.0|
Artery, Inflammation, Chronic | 3 3 3 3 2 3 2 3 3 2 3 3 2| 26 2.6|
Bilateral, Cyst | | 2 2.5|
Interstitial Cell, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 | 2 2.0|
Cyst | 3 | 1 3.0|
Hemorrhage | 3 | 1 3.0|
Hydrometra | 3 3 3 2 3 2 3 3 | 19 2.7|
Artery, Inflammation, Chronic, Focal | 3 3 3 3 3 3 2 2 3 2 1| 21 2.4|
Artery, Inflammation | 3 | 2 3.0|
Endometrium, Hyperplasia, Cystic | 2 3 3 1 2 3 3 3 3 3 3 3 3 3 3 3 3 1 3| 41 2.8|
|__________________________________________________________________________|____________|
Vagina | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 3 | 6 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 15 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Histiocytic | 3 | 1 3.0|
Bronchial, Hyperplasia, Lymphoid | | 1 2.0|
Bronchial, Hyperplasia, Plasma Cell | | 1 3.0|
Deep Cervical, Hyperplasia, Lymphoid | 3 | 1 3.0|
Iliac, Hyperplasia, Plasma Cell | | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 2 3.0|
Renal, Angiectasis | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4| |
DAY ON TEST | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3| |
| 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Renal, Hemorrhage | | 2 4.0|
Renal, Hyperplasia, Plasma Cell | | 1 4.0|
Renal, Inflammation, Suppurative | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + M +| 47 |
Fibrosis | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Fibrosis | 4 | 1 4.0|
Hematopoietic Cell Proliferation | | 4 2.5|
Hemorrhage | 2 | 4 2.5|
Hyperplasia, Histiocytic | 3 3 | 2 3.0|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Hyperplasia, Plasma Cell | | 1 3.0|
Artery, Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 4 3 3 3 4 3 4 3 4 3 3 4 3 2 3 3 4 2 3 4 2| 43 3.1|
Hyperplasia, Lymphoid | 2 3 2 | 4 2.5|
Artery, Inflammation, Chronic, Focal | 2 1 2 1 3 | 6 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + I + + + + + + M + + + + I + M I + +| 39 |
Atrophy | 2 | 2 2.5|
Cyst | | 1 2.0|
Hyperplasia, Histiocytic | | 1 3.0|
Artery, Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4| |
DAY ON TEST | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3| |
| 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Ectasia | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Subcutaneous Tissue, | | |
Inflammation, Chronic | | 1 2.0|
Dermis, Edema, Focal | 3 | 1 3.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | | 1 2.0|
Vertebra, Hyperostosis, Focal | 3 3 3 2 3 3 3 3 3 3 3 3 3 2 3 2 | 33 2.9|
|__________________________________________________________________________|____________|
Skeletal Muscle | + +| 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 4 | 1 4.0|
Gliosis | | 1 1.0|
Hemorrhage, Focal | 2 2 2 | 4 2.0|
Artery, Meninges, Inflammation, | | |
Chronic | 3| 1 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + +| 6 |
Spinal, Ganglion, Inflammation, | | |
Chronic | 3| 1 3.0|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + +| 6 |
Hemorrhage, Focal | 1 | 1 1.0|
Meninges, Inflammation, Chronic | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4| |
DAY ON TEST | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3| |
| 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 2 3.0|
Hemorrhage | 3 2 2 | 4 2.3|
Hyperplasia, Focal, Mast Cell | 2 | 1 2.0|
Hyperplasia, Histiocytic | 3 2 1 2 2 3 | 9 2.1|
Infiltration Cellular, Mixed Cell | 2 3 | 3 2.3|
Alveolar Epithelium, Hyperplasia | 2 1 2 1| 6 1.5|
Artery, Mediastinum, Inflammation, | | |
Chronic | 2 | 2 2.0|
Mediastinum, Inflammation, Chronic | 2 | 1 2.0|
Mediastinum, Inflammation, | | |
Suppurative | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pleura | + | 1 |
Inflammation, Suppurative | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 2 |
Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 2 | 2 1.5|
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 4| 7| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 4| |
DAY ON TEST | 3| 3| 2| 9| 2| 3| 3| 8| 3| 3| 0| 9| 3| 8| 9| 2| 0| 2| 7| 3| 2| 1| 8| 3| 3| |
| 2| 0| 9| 1| 0| 5| 1| 9| 5| 7| 9| 6| 0| 1| 6| 9| 9| 2| 5| 4| 9| 3| 7| 7| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Metaplasia, Focal, Osseous | 2 1 1 | 8 1.5|
Mineralization, Focal | | 1 3.0|
Nephropathy | 4 4 2 4 4 4 3 4 3 4 4 3 2 4 3 4 4 4 2 3 4 3 3 | 47 3.4|
Artery, Inflammation, Chronic | 2 2 2 2 2 1 2 2 2 2 2 2 | 16 2.1|
Artery, Mineralization | | 1 1.0|
Glomerulus, Glomerulosclerosis | 2 3 3 1 3 3 3 3 3 3 3 3 1 3 3 4 3 3 1 3 2 | 40 2.7|
Pelvis, Dilatation | | 1 3.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 2 3 3 3 2 3 2 3 3 2 3 3 | 14 2.6|
Renal Tubule, Dilatation | 1 | 2 1.0|
Renal Tubule, Karyomegaly | | 1 2.0|
Renal Tubule, Pigmentation | 3 3 3 3 3 3 3 3 3 3 3 3 3 | 27 2.8|
|__________________________________________________________________________|____________|
Ureter | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + A + + +| 48 |
Artery, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 2| 3| 2| 2| 2| 3| 2| 3| 3| 3| 2| 3| 3| 6| 2| 3| 2| 3| 3| 1|
| 0| 1| 0| 3| 4| 9| 4| 9| 9| 9| 1| 9| 3| 0| 1| 9| 4| 0| 1| 9| 4| 9| 4| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + M + + + + + A + + + + + M|
Cyst | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + M + + + + + + + A + + + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + M + + + + + A + + + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + + + + + + A + + + + + A + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Clear Cell Focus | X X |
Cyst | |
Eosinophilic Focus | 2 X X |
Fibrosis, Focal | 1 |
Infarct | |
Infiltration Cellular, Mixed Cell | 2 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2|
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | |
Hepatocyte, Cytomegaly | 1|
Hepatocyte, Eosinophilic Focus | 1 |
Hepatocyte, Karyomegaly | 1|
Hepatocyte, Necrosis, Focal | 1 1 1 1 1 1 1 1 1 |
Hepatocyte, Syncytial Alteration, | |
Focal | 1 2 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Hepatocyte, Vacuolization | |
Cytoplasmic, Diffuse | |
Hepatocyte, Vacuolization | |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 2| 3| 2| 2| 2| 3| 2| 3| 3| 3| 2| 3| 3| 6| 2| 3| 2| 3| 3| 1|
| 0| 1| 0| 3| 4| 9| 4| 9| 9| 9| 1| 9| 3| 0| 1| 9| 4| 0| 1| 9| 4| 9| 4| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Cytoplasmic, Focal | 2 2 1 2 2 2 2 2 |
Hepatocyte, Midzonal, Vacuolization | |
Cytoplasmic | 1 2 3 2 2 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + |
Angiectasis | 2 |
Artery, Inflammation, Chronic, Focal | 2 |
Fat, Necrosis | 3 2 3 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Necrosis, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Focal | |
Ulcer | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +|
Pigmentation, Focal | 1 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + |
Malformation | 2 2 2 1 1 2 3 |
Peridontal Tissue, Inflammation, | |
Chronic | 3 2 3 4 3 2 4 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 2| 3| 2| 2| 2| 3| 2| 3| 3| 3| 2| 3| 3| 6| 2| 3| 2| 3| 3| 1|
| 0| 1| 0| 3| 4| 9| 4| 9| 9| 9| 1| 9| 3| 0| 1| 9| 4| 0| 1| 9| 4| 9| 4| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 1 1 1 1 1 1 1 1 |
Hyperplasia, Focal | 1 |
Hyperplasia | |
Capsule, Hyperplasia, Focal | 2 2 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + M M + + + + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 1 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 1 2 1 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Degeneration, Cystic | 3 3 3 4 3 3 3 3 3 3 2|
|__________________________________________________________________________|
Prostate, NOS | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 2| 3| 2| 2| 2| 3| 2| 3| 3| 3| 2| 3| 3| 6| 2| 3| 2| 3| 3| 1|
| 0| 1| 0| 3| 4| 9| 4| 9| 9| 9| 1| 9| 3| 0| 1| 9| 4| 0| 1| 9| 4| 9| 4| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Dilatation | 3 3 3 2 3 2 3 3 3 2 |
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Pancreatic, Hyperplasia, Plasma Cell | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 |
Hyperplasia, Plasma Cell | 3 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 1 3 2 2 2 3|
Hyperplasia, Plasma Cell | 2 |
|__________________________________________________________________________|
Thymus | + + + I + + + + + + + + M + + + + + + + + + + M +|
Cyst | 1 1 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | |
Vertebra, Hyperostosis, Focal | 3 3 3 3 2 3 3 3 3 3 1 3 3 3 3 3 3 3 3 3 3 |
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 2| 3| 2| 2| 2| 3| 2| 3| 3| 3| 2| 3| 3| 6| 2| 3| 2| 3| 3| 1|
| 0| 1| 0| 3| 4| 9| 4| 9| 9| 9| 1| 9| 3| 0| 1| 9| 4| 0| 1| 9| 4| 9| 4| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Histiocytic | 3 |
Hyperplasia, Histiocytic | 2 |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Edema | |
Mediastinum, Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + +|
|__________________________________________________________________________|
Zymbal's Gland | |
Cyst, Squamous | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 1 |
Inflammation, Chronic, Focal | |
Metaplasia, Focal, Osseous | 1 2 1 |
Nephropathy | 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Dilatation | 1 1 1 1 1 1 2 1 2 1 |
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 36
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 7| 2| 3| 7| 9| 3| 2| 3| 3| 3| 8| 3| 2| 2| 3| 3| 0| 8| 2| 2| 2| 3| |
| 0| 4| 9| 5| 9| 1| 5| 9| 4| 9| 4| 0| 0| 6| 7| 9| 9| 4| 1| 6| 8| 9| 9| 9| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + A + + + A + + + + + + + + + + + + + + + + +| 44 |
Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + A + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + A + + + + + + A + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + A + + + + + + A + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + A + + + + + + A + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + A + + + + + + A + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + A + + + + + + A + + + + + + + + + +| 44 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 3 | 1 3.0|
Clear Cell Focus | X X X X X| 7 |
Cyst | 3 | 1 3.0|
Eosinophilic Focus | X X X | 6 2.0|
Fibrosis, Focal | | 1 1.0|
Infarct | 4 | 1 4.0|
Infiltration Cellular, Mixed Cell | 1 3 1 3 1 3 1 1 1 1 3 1 1 1 1 | 33 1.4|
Mixed Cell Focus | | 3 |
Bile Duct, Hyperplasia | 2 2 | 2 2.0|
Hepatocyte, Cytomegaly | 2 2 1 | 4 1.5|
Hepatocyte, Eosinophilic Focus | 2 | 2 1.5|
Hepatocyte, Karyomegaly | 2 2 1 | 4 1.5|
Hepatocyte, Necrosis, Focal | 1 1 3 1 1 3 2 1 1 | 18 1.3|
Hepatocyte, Syncytial Alteration, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 7| 2| 3| 7| 9| 3| 2| 3| 3| 3| 8| 3| 2| 2| 3| 3| 0| 8| 2| 2| 2| 3| |
| 0| 4| 9| 5| 9| 1| 5| 9| 4| 9| 4| 0| 0| 6| 7| 9| 9| 4| 1| 6| 8| 9| 9| 9| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Focal | 1 2 1 1 1 1 1 2 2 1 2 1 1 1 1 1| 38 1.2|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | 3 2 3 | 3 2.7|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 2 2 2 2 2 2 1 2 2| 18 1.9|
Hepatocyte, Midzonal, Vacuolization | | |
Cytoplasmic | 2 2 | 8 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 12 |
Angiectasis | | 1 2.0|
Artery, Inflammation, Chronic, Focal | 2 | 2 2.0|
Fat, Necrosis | 2 3 3 3 | 9 2.8|
|__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis, Focal | 2 | 1 2.0|
Necrosis, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 1 | 1 1.0|
Inflammation, Focal | 2 1 | 2 1.5|
Ulcer | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + + A + + + + + + + + + +| 47 |
Pigmentation, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + | 24 |
Malformation | 4 2 2 3 2 3 | 13 2.2|
Peridontal Tissue, Inflammation, | | |
Chronic | 2 2 3 4 3 2 1 | 16 2.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 7| 2| 3| 7| 9| 3| 2| 3| 3| 3| 8| 3| 2| 2| 3| 3| 0| 8| 2| 2| 2| 3| |
| 0| 4| 9| 5| 9| 1| 5| 9| 4| 9| 4| 0| 0| 6| 7| 9| 9| 4| 1| 6| 8| 9| 9| 9| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Cytoplasmic Alteration, Focal | 2 3 1 1 2 2 1 1 1 | 18 1.3|
Hyperplasia, Focal | | 1 1.0|
Hyperplasia | 2 | 1 2.0|
Capsule, Hyperplasia, Focal | 2 | 5 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + M M M + A + + + + M + + + + +| 41 |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | 1 1 | 5 1.2|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Degeneration, Cystic, Focal | 1 2 1 | 8 1.4|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 7| 2| 3| 7| 9| 3| 2| 3| 3| 3| 8| 3| 2| 2| 3| 3| 0| 8| 2| 2| 2| 3| |
| 0| 4| 9| 5| 9| 1| 5| 9| 4| 9| 4| 0| 0| 6| 7| 9| 9| 4| 1| 6| 8| 9| 9| 9| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Degeneration, Cystic | 3 3 3 3 3 3 3 3| 19 3.0|
|__________________________________________________________________________|____________|
Prostate, NOS | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 3 3 3 3 | 15 2.8|
Inflammation, Chronic | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + | 2 |
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Hyperplasia, Plasma Cell | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 3 2.3|
Hyperplasia, Plasma Cell | | 2 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 4 3 3 3 2 2 2 2 2 2| 18 2.3|
Hyperplasia, Plasma Cell | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 7| 2| 3| 7| 9| 3| 2| 3| 3| 3| 8| 3| 2| 2| 3| 3| 0| 8| 2| 2| 2| 3| |
| 0| 4| 9| 5| 9| 1| 5| 9| 4| 9| 4| 0| 0| 6| 7| 9| 9| 4| 1| 6| 8| 9| 9| 9| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + M M M + + + + M + + +| 42 |
Cyst | 2 2 2| 6 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | 3 | 1 3.0|
Vertebra, Hyperostosis, Focal | 3 3 2 3 3 3 3 3 3 3 3 3 3 3 2 3| 37 2.9|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal, Histiocytic | | 1 3.0|
Hyperplasia, Histiocytic | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Interstitium, Edema | 2 | 1 2.0|
Mediastinum, Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 7| 2| 3| 7| 9| 3| 2| 3| 3| 3| 8| 3| 2| 2| 3| 3| 0| 8| 2| 2| 2| 3| |
| 0| 4| 9| 5| 9| 1| 5| 9| 4| 9| 4| 0| 0| 6| 7| 9| 9| 4| 1| 6| 8| 9| 9| 9| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 6 |
|__________________________________________________________________________|____________|
Zymbal's Gland | +| 1 |
Cyst, Squamous | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 2 2 2 2 | 8 1.8|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Metaplasia, Focal, Osseous | | 3 1.3|
Nephropathy | 1 1 1 4 1 2 2 1 2 1 1 1 1 3 1 1 1 1 2 1 2 1| 46 1.3|
Renal Tubule, Dilatation | 1 2 1 1 1 1 | 16 1.2|
Renal Tubule, Pigmentation | 3 1 | 2 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 9| 8| 8| 3| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|
| 4| 1| 4| 9| 1| 9| 1| 6| 1| 7| 1| 4| 9| 4| 4| 9| 4| 0| 9| 0| 4| 1| 9| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.1 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + M + + M + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Diverticulum | |
Edema | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
Clear Cell Focus | X X X |
Congestion, Focal | |
Eosinophilic Focus | X X X X X |
Hemorrhage, Focal | 3 |
Infarct | |
Infiltration Cellular, Mixed Cell | 1 1 1 2 1 2 1 2 2 1 |
Inflammation, Chronic, Focal, | |
Suppurative | 3 |
Hepatocyte, Basophilic Focus | |
Hepatocyte, Cytomegaly | 2 2 2 1 |
Hepatocyte, Eosinophilic Focus | 1 |
Hepatocyte, Karyomegaly | 2 2 2 1 |
Hepatocyte, Necrosis, Focal | 1 1 3 1 |
Hepatocyte, Syncytial Alteration, | |
Focal | 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 2|
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 9| 8| 8| 3| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|
| 4| 1| 4| 9| 1| 9| 1| 6| 1| 7| 1| 4| 9| 4| 4| 9| 4| 0| 9| 0| 4| 1| 9| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.1 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 2 |
Hepatocyte, Centrilobular, Necrosis | 3 |
Hepatocyte, Midzonal, Vacuolization | |
Cytoplasmic | 2 2 2 2 3 3 2 2 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + +|
Angiectasis | 2 |
Artery, Inflammation, Chronic, Focal | |
Fat, Necrosis | 3 3 1 2 3|
|__________________________________________________________________________|
Oral Mucosa | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1|
Inflammation, Focal | 2|
Epithelium, Hyperplasia | 2 2|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia, Focal | 3 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + |
Malformation | 1 3 |
Peridontal Tissue, Inflammation, | |
Chronic | 2 3 2 3 3 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 1 2 |
Artery, Inflammation, Chronic | 1 |
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 9| 8| 8| 3| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|
| 4| 1| 4| 9| 1| 9| 1| 6| 1| 7| 1| 4| 9| 4| 4| 9| 4| 0| 9| 0| 4| 1| 9| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.1 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | 3 |
Cyst | 2 |
Cytoplasmic Alteration, Focal | 1 1 1 |
Capsule, Hyperplasia, Focal | 2 2 3 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Cyst | 2 2 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 3 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
Pelvic, Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 3 3 3 3 3 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Prostate, NOS | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 9| 8| 8| 3| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|
| 4| 1| 4| 9| 1| 9| 1| 6| 1| 7| 1| 4| 9| 4| 4| 9| 4| 0| 9| 0| 4| 1| 9| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.1 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 2 2 3 2 2 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node | + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 3 2 3|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Thymus | + I + + + M + + + + M + + + + + I + + + + + + + +|
Cyst | 2 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 2|
Subcutaneous Tissue, Lip, | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 9| 8| 8| 3| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|
| 4| 1| 4| 9| 1| 9| 1| 6| 1| 7| 1| 4| 9| 4| 4| 9| 4| 0| 9| 0| 4| 1| 9| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.1 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Hyperostosis, Focal | 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
Alveolar Epithelium, Hyperplasia | 2 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Sinus, Foreign Body | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
|__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Infarct | |
Metaplasia, Focal, Osseous | 1 1|
Nephropathy | 2 1 1 2 2 2 2 2 3 1 2 2 1 1 1 1 1 1 1 3 2 1 1 1|
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 9| 8| 8| 3| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|
| 4| 1| 4| 9| 1| 9| 1| 6| 1| 7| 1| 4| 9| 4| 4| 9| 4| 0| 9| 0| 4| 1| 9| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.1 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Glomerulus, Glomerulosclerosis | |
Pelvis, Dilatation | 2 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 3 |
Renal Tubule, Dilatation | 1 1 1 1 1 1 1 1 1 2 1 |
Renal Tubule, Vacuolization | |
Cytoplasmic | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 48
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 6| 2| 3| 3| 3| 4| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| |
| 4| 0| 4| 6| 9| 0| 1| 0| 2| 9| 4| 4| 4| 9| 9| 0| 3| 4| 4| 4| 1| 6| 4| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
0.1 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | M + + A + + + + + + A + + + + + + + + + I + + + +| 43 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + A + + + + + + + + + + + + + +| 47 |
Diverticulum | X | 1 |
Edema | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + A + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + A + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 | 1 1.0|
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 1 1.0|
Clear Cell Focus | X X | 5 |
Congestion, Focal | 2 3 2 | 3 2.3|
Eosinophilic Focus | X | 6 |
Hemorrhage, Focal | 2 | 2 2.5|
Infarct | 4 3 | 2 3.5|
Infiltration Cellular, Mixed Cell | 1 2 1 1 2 1 1 1 1 1 1 1 2 1 1 | 25 1.3|
Inflammation, Chronic, Focal, | | |
Suppurative | | 1 3.0|
Hepatocyte, Basophilic Focus | 1 | 1 1.0|
Hepatocyte, Cytomegaly | | 4 1.8|
Hepatocyte, Eosinophilic Focus | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 6| 2| 3| 3| 3| 4| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| |
| 4| 0| 4| 6| 9| 0| 1| 0| 2| 9| 4| 4| 4| 9| 9| 0| 3| 4| 4| 4| 1| 6| 4| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
0.1 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Karyomegaly | | 4 1.8|
Hepatocyte, Necrosis, Focal | 1 1 2 1 1 | 9 1.3|
Hepatocyte, Syncytial Alteration, | | |
Focal | 1 2 1 1 2 2 2 1 1 1 1 1| 30 1.2|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 2 2 1 1 | 7 1.7|
Hepatocyte, Centrilobular, Necrosis | | 1 3.0|
Hepatocyte, Midzonal, Vacuolization | | |
Cytoplasmic | 2 3 3 2 2 | 14 2.3|
|__________________________________________________________________________|____________|
Mesentery | + + + | 10 |
Angiectasis | | 1 2.0|
Artery, Inflammation, Chronic, Focal | 2 | 1 2.0|
Fat, Necrosis | 2 2 | 8 2.3|
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 1.0|
Inflammation, Focal | | 1 2.0|
Epithelium, Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + + | 15 |
Malformation | 3 | 3 2.3|
Peridontal Tissue, Inflammation, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 6| 2| 3| 3| 3| 4| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| |
| 4| 0| 4| 6| 9| 0| 1| 0| 2| 9| 4| 4| 4| 9| 9| 0| 3| 4| 4| 4| 1| 6| 4| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
0.1 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Chronic | 2 3 2 3 3 | 12 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | 2 | 3 1.7|
Artery, Inflammation, Chronic | 3 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 1 1 1 | 3 1.0|
Angiectasis | | 1 3.0|
Cyst | 2 | 2 2.0|
Cytoplasmic Alteration, Focal | 1 1 2 2| 7 1.3|
Capsule, Hyperplasia, Focal | 2 2 1 | 7 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + M + M + + + + + + + + + +| 47 |
Pars Distalis, Cyst | 1 | 4 1.8|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 1 2 1 | 8 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + + | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 6| 2| 3| 3| 3| 4| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| |
| 4| 0| 4| 6| 9| 0| 1| 0| 2| 9| 4| 4| 4| 9| 9| 0| 3| 4| 4| 4| 1| 6| 4| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
0.1 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM - cont | | |
Pelvic, Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 3 3 3 3 3 3 3 3 3 3| 19 3.0|
Inflammation, Chronic | 3 4 | 2 3.5|
|__________________________________________________________________________|____________|
Prostate, NOS | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 3 2 2 3| 13 2.5|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node | + | 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + A + I + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
Hyperplasia, Plasma Cell | 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 6| 2| 3| 3| 3| 4| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| |
| 4| 0| 4| 6| 9| 0| 1| 0| 2| 9| 4| 4| 4| 9| 9| 0| 3| 4| 4| 4| 1| 6| 4| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
0.1 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hematopoietic Cell Proliferation | 2 3 3 2 3 2 3 3 3 2| 16 2.6|
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Cyst | 1 2 2 2 | 5 1.8|
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 2.0|
Subcutaneous Tissue, Lip, | | |
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vertebra, Hyperostosis, Focal | 3 3 3 3 3 3 3 3 2 2 3 2 3 2 2 2| 36 2.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 6| 2| 3| 3| 3| 4| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| |
| 4| 0| 4| 6| 9| 0| 1| 0| 2| 9| 4| 4| 4| 9| 9| 0| 3| 4| 4| 4| 1| 6| 4| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
0.1 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Alveolar Epithelium, Hyperplasia | 2 | 3 1.7|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 | 1 3.0|
Sinus, Foreign Body | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 2 | 4 2.3|
Infarct | 3 | 1 3.0|
Metaplasia, Focal, Osseous | 2 | 3 1.3|
Nephropathy | 1 2 1 2 1 1 1 1 2 1 2 2 1 2 1 2 1 1 1 2 1 1 2 2| 48 1.5|
Glomerulus, Glomerulosclerosis | 1 | 1 1.0|
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 2 3.0|
Renal Tubule, Dilatation | 1 1 1 1 1 1| 17 1.1|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 9| 2| 3| 2| 2| 2| 3| 3| 5| 1| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 6| 3| 3| 2|
| 4| 2| 9| 1| 9| 0| 9| 0| 1| 7| 4| 1| 9| 4| 1| 4| 0| 9| 0| 9| 0| 7| 0| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + + + A + + + + A + + + + + M I + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + A + + + + + + + + + + A + + +|
Edema | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + A + + + + + + + + + + A + + +|
Inflammation, Focal | |
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + A + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Congestion, Focal | 4 1 |
Congestion | 3 |
Eosinophilic Focus | X X |
Hemorrhage, Focal | |
Infarct | 4 4 |
Infiltration Cellular, Mixed Cell | 1 1 2 2 1 1|
Karyomegaly | 1 |
Bile Duct, Hyperplasia | 1 |
Hepatocyte, Cytomegaly | 2 3 2 1 1 1 1|
Hepatocyte, Eosinophilic Focus | X |
Hepatocyte, Karyomegaly | 2 3 2 1 1 1|
Hepatocyte, Mixed Cell Focus | |
Hepatocyte, Necrosis, Focal | 2 2 |
Hepatocyte, Syncytial Alteration, | |
Focal | 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1|
Hepatocyte, Vacuolization | |
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 9| 2| 3| 2| 2| 2| 3| 3| 5| 1| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 6| 3| 3| 2|
| 4| 2| 9| 1| 9| 0| 9| 0| 1| 7| 4| 1| 9| 4| 1| 4| 0| 9| 0| 9| 0| 7| 0| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Cytoplasmic, Focal | 2 |
Hepatocyte, Periportal, | |
Vacuolization Cytoplasmic | |
Hepatocyte, Centrilobular, Necrosis | 4 |
Hepatocyte, Midzonal, Vacuolization | |
Cytoplasmic | 3 2 2 2 3 |
|__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic | 2 |
Fat, Necrosis | 3 3 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Focal | 3 2 |
Ulcer | 3 |
Epithelium, Hyperplasia | 3 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Degeneration, Cystic, Focal | |
|__________________________________________________________________________|
Tooth | + + + + + + + +|
Malformation | 3 2 2 |
Peridontal Tissue, Inflammation, | |
Chronic | 3 3 3 2 3 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 1 1 |
Inflammation, Chronic, Focal | 1|
Artery, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 9| 2| 3| 2| 2| 2| 3| 3| 5| 1| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 6| 3| 3| 2|
| 4| 2| 9| 1| 9| 0| 9| 0| 1| 7| 4| 1| 9| 4| 1| 4| 0| 9| 0| 9| 0| 7| 0| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | |
Cyst | 3 |
Cytoplasmic Alteration, Focal | 2 2 2 2 |
Hyperplasia, Focal | |
Capsule, Fibrosis, Focal | |
Capsule, Hyperplasia, Focal | 2 1 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + M M +|
|__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 |
Pars Distalis, Hyperplasia, Focal | |
Pars Intermedia, Cyst | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 2 2 2 2 2|
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 3 3 3 3 3 3 3 3|
Inflammation, Chronic | |
|__________________________________________________________________________|
Prostate, NOS | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 57
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 9| 2| 3| 2| 2| 2| 3| 3| 5| 1| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 6| 3| 3| 2|
| 4| 2| 9| 1| 9| 0| 9| 0| 1| 7| 4| 1| 9| 4| 1| 4| 0| 9| 0| 9| 0| 7| 0| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 3 3 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
Bronchial, Hyperplasia, Plasma Cell | 3 |
Inguinal, Inflammation, Chronic, | |
Focal | |
Mediastinal, Hyperplasia, Plasma Cell| |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 3 |
Infiltration Cellular, | |
Polymorphonuclear | 3 |
Inflammation, Focal, Suppurative | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 3 2 2 2 3 2|
Hyperplasia, Lymphoid | X 3 |
|__________________________________________________________________________|
Thymus | I M + + + + + + + M + + + + + + + + + + + + + + +|
Cyst | 3 |
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 9| 2| 3| 2| 2| 2| 3| 3| 5| 1| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 6| 3| 3| 2|
| 4| 2| 9| 1| 9| 0| 9| 0| 1| 7| 4| 1| 9| 4| 1| 4| 0| 9| 0| 9| 0| 7| 0| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Hyperostosis, Focal | 3 3 3 3 3 3 3 3 3 1 3 3 3 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Pigmentation, Focal | |
|__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Histiocytic | 3 |
Infiltration Cellular, Mixed Cell | |
Alveolar Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Sinus, Foreign Body | 3 |
Sinus, Inflammation, Chronic, | |
Suppurative | 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 9| 2| 3| 2| 2| 2| 3| 3| 5| 1| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 6| 3| 3| 2|
| 4| 2| 9| 1| 9| 0| 9| 0| 1| 7| 4| 1| 9| 4| 1| 4| 0| 9| 0| 9| 0| 7| 0| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Congestion | 2 3 3 2 2 |
Cyst | 2 2 2 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | |
Nephropathy | 3 2 2 2 1 1 1 2 1 3 1 1 2 2 2 1 2 1 1 2 1 2 2 1|
Artery, Inflammation, Chronic | 1 |
Pelvis, Dilatation | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Dilatation | 1 2 1 2 1 2 2 1 1 1 1 |
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 3 |
__________________________________________|__________________________________________________________________________
Page 60
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3| |
| 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | M + M + + + + + A + + M + A M + M + + + M + + + +| 36 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + A + A + + + + + + + + + + +| 44 |
Edema | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + A + A + + + + + + + + + + +| 44 |
Inflammation, Focal | 3 | 1 3.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + A + A + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X X X X| 4 |
Congestion, Focal | | 2 2.5|
Congestion | | 1 3.0|
Eosinophilic Focus | | 2 |
Hemorrhage, Focal | 3 | 1 3.0|
Infarct | 4 | 3 4.0|
Infiltration Cellular, Mixed Cell | 2 1 1 2 1 1 2 1 | 14 1.4|
Karyomegaly | | 1 1.0|
Bile Duct, Hyperplasia | | 1 1.0|
Hepatocyte, Cytomegaly | 2 3 1 1 1 3 1 2 2| 16 1.7|
Hepatocyte, Eosinophilic Focus | | 1 |
Hepatocyte, Karyomegaly | 2 3 1 1 1 3 1 2 2| 15 1.7|
Hepatocyte, Mixed Cell Focus | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3| |
| 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Necrosis, Focal | 3 1 1 | 5 1.8|
Hepatocyte, Syncytial Alteration, | | |
Focal | 1 1 1 1 1 2 2 1 1 1 2 1 1 1 2| 31 1.2|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 1 | 3 1.7|
Hepatocyte, Periportal, | | |
Vacuolization Cytoplasmic | 2 | 1 2.0|
Hepatocyte, Centrilobular, Necrosis | 3 3 | 3 3.3|
Hepatocyte, Midzonal, Vacuolization | | |
Cytoplasmic | 2 3 1 | 8 2.3|
|__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | 2 2 3 3 | 8 2.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | 2 | 1 2.0|
Inflammation, Focal | | 2 2.5|
Ulcer | | 1 3.0|
Epithelium, Hyperplasia | | 2 2.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Glands, Degeneration, Cystic, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + | 18 |
Malformation | 2 2 2 3 2 | 8 2.3|
Peridontal Tissue, Inflammation, | | |
Chronic | 2 3 3 3 2 3 | 12 2.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3| |
| 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | 1 | 3 1.0|
Inflammation, Chronic, Focal | | 1 1.0|
Artery, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 1 1.0|
Angiectasis | 2 | 1 2.0|
Cyst | | 1 3.0|
Cytoplasmic Alteration, Focal | 2 2 1 1 | 8 1.8|
Hyperplasia, Focal | 3 | 1 3.0|
Capsule, Fibrosis, Focal | 3 | 1 3.0|
Capsule, Hyperplasia, Focal | 2 1 | 6 1.7|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + M + + M + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | 1 | 2 1.5|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 1 2 | 2 1.5|
Pars Intermedia, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic, Focal | 1 2 2 1 2 2 | 12 1.8|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3| |
| 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 3 3 3 3 | 16 3.0|
Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Prostate, NOS | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 2 2 | 8 2.5|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Bronchial, Hyperplasia, Plasma Cell | | 1 3.0|
Inguinal, Inflammation, Chronic, | | |
Focal | 2 | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + A + + + + + I + + + + + + +| 48 |
Congestion | | 1 4.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3| |
| 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Plasma Cell | 3 3 | 4 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
Inflammation, Focal, Suppurative | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 2 2 3 2 3 4 4 1 3 | 19 2.6|
Hyperplasia, Lymphoid | 3 | 3 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + + I + + + + + + + + +| 45 |
Cyst | 2 1 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Edema | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vertebra, Hyperostosis, Focal | 3 3 3 1 3 3 2 3 2 3 3 3 3 3 3 3 2 3 3 2 3 2 2| 38 2.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 | 1 2.0|
Pigmentation, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | M | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3| |
| 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Larynx | | 1 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hyperplasia, Histiocytic | 3 3 3 | 4 3.0|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
Sinus, Foreign Body | | 1 3.0|
Sinus, Inflammation, Chronic, | | |
Suppurative | | 1 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 3 | 1 3.0|
Congestion | | 5 2.4|
Cyst | 2 1 2 | 6 1.8|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Chronic, Focal | 3 | 1 3.0|
Nephropathy | 2 1 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 3 1 3 3 2| 48 1.8|
Artery, Inflammation, Chronic | 2 | 2 1.5|
Pelvis, Dilatation | 2 | 1 2.0|
Renal Tubule, Accumulation, Hyaline | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 3| 1| 3| 2| 3| 3| 0| 3| 2| 2| 3| 3| 2| 3| 3| |
| 1| 4| 1| 1| 9| 9| 4| 4| 3| 9| 1| 9| 4| 8| 1| 4| 0| 0| 9| 9| 4| 1| 2| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Droplet | | 1 3.0|
Renal Tubule, Dilatation | 1 1 1 1 1 1 1 1 2 2 1 2 2| 24 1.3|
Renal Tubule, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 5| 0| 3| 2| 0| 3| 3| 2| 3| 3| 6| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3|
| 9| 1| 1| 9| 4| 7| 9| 9| 7| 0| 4| 9| 4| 0| 1| 1| 4| 2| 4| 4| 4| 9| 4| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + A + + + M + + + A M + A + + + M + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Clear Cell Focus | X |
Congestion, Focal | 3 2 2 |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage, Focal | 3 2 2 3 |
Infiltration Cellular, Mixed Cell | 1 2 3 2 1 1 2|
Inflammation, Chronic | |
Metaplasia, Focal, Lipocyte | 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 2 1 |
Endothelial Cell, Hyperplasia, Focal | 2 |
Endothelial Cell, Hyperplasia | 2 |
Hepatocyte, Cytomegaly | 1 1 1 3 3 1 2 2 3 2 2 2 1 3 1 2 1 1|
Hepatocyte, Karyomegaly | 1 1 1 4 3 1 2 2 3 2 2 2 1 3 1 2 1 1|
Hepatocyte, Necrosis, Focal | 1 2 |
Hepatocyte, Syncytial Alteration, | |
Focal | 1 2 1 1 1 1 1 1 1 1 1 1 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 1 |
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 5| 0| 3| 2| 0| 3| 3| 2| 3| 3| 6| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3|
| 9| 1| 1| 9| 4| 7| 9| 9| 7| 0| 4| 9| 4| 0| 1| 1| 4| 2| 4| 4| 4| 9| 4| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hepatocyte, Centrilobular, Necrosis | 3 3 4 3 |
Hepatocyte, Centrilobular, | |
Vacuolization Cytoplasmic | 2 |
Hepatocyte, Midzonal, Vacuolization | |
Cytoplasmic | 2 |
Sinusoid, Dilatation, Diffuse | 4 |
|__________________________________________________________________________|
Mesentery | + + + + + +|
Artery, Inflammation, Chronic, Focal | 2 |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + + +|
Pigmentation, Focal | 2 |
Glands, Degeneration, Cystic, Focal | |
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 1 |
Mineralization, Focal | 2 |
Artery, Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Cytoplasmic Alteration, Focal | 2 2 2 2 2 2 |
Cytoplasmic Alteration | 4|
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 5| 0| 3| 2| 0| 3| 3| 2| 3| 3| 6| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3|
| 9| 1| 1| 9| 4| 7| 9| 9| 7| 0| 4| 9| 4| 0| 1| 1| 4| 2| 4| 4| 4| 9| 4| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hemorrhage | |
Hypertrophy | 2 |
Bilateral, Capsule, Fibrosis | 4 |
Capsule, Hyperplasia, Focal | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | |
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 3 3 3 3 3 3 3 3 3|
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Prostate, NOS | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 70
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 5| 0| 3| 2| 0| 3| 3| 2| 3| 3| 6| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3|
| 9| 1| 1| 9| 4| 7| 9| 9| 7| 0| 4| 9| 4| 0| 1| 1| 4| 2| 4| 4| 4| 9| 4| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Dilatation | 2 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + +|
Mediastinal, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
Hyperplasia, Plasma Cell | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 4 3 3 3 3 3 |
Hyperplasia, Lymphoid | 3 2 3 |
Artery, Inflammation, Chronic, Focal | 2 |
|__________________________________________________________________________|
Thymus | + M + M + M + + + + + I + + + + + M + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Subcutaneous Tissue, Edema | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 5| 0| 3| 2| 0| 3| 3| 2| 3| 3| 6| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3|
| 9| 1| 1| 9| 4| 7| 9| 9| 7| 0| 4| 9| 4| 0| 1| 1| 4| 2| 4| 4| 4| 9| 4| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Vertebra, Hyperostosis, Focal | 3 3 3 3 3 3 3 2|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 3 2 2 |
Hyperplasia, Focal, Histiocytic | |
Hyperplasia, Histiocytic | |
Metaplasia, Focal, Osseous | |
Pigmentation, Focal | |
Alveolar Epithelium, Hyperplasia | 2 2 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | 2 1 1 2 |
Metaplasia, Focal, Osseous | 2 2 1 1 2 |
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 5| 0| 3| 2| 0| 3| 3| 2| 3| 3| 6| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3|
| 9| 1| 1| 9| 4| 7| 9| 9| 7| 0| 4| 9| 4| 0| 1| 1| 4| 2| 4| 4| 4| 9| 4| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Nephropathy | 2 2 2 3 2 4 2 2 2 2 2 2 1 2 2 2 2 2 3 2 3 2 2 2 2|
Glomerulus, Glomerulosclerosis | 1 1 4 2 2 2 2 2 2 2 2 2 1 2 2 3 1 1 1 2 1 |
Papilla, Necrosis | 3 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
Renal Tubule, Dilatation | 1 1 2 2 1 2 2 2 1 2 2 1 |
Renal Tubule, Necrosis, Focal | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 73
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 2| 3| 3| 3| 2| 3| 2| 3| 8| 3| 2| 3| 3| 3| 6| 3| 3| 5| 2| 3| 3| |
| 0| 4| 6| 4| 9| 4| 4| 4| 9| 1| 0| 1| 9| 1| 9| 0| 0| 4| 1| 4| 0| 2| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + A + + + + + + + + + A M + +| 41 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 3 2 | 6 2.3|
Clear Cell Focus | | 1 |
Congestion, Focal | 3 | 4 2.5|
Eosinophilic Focus | X | 1 |
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Hemorrhage, Focal | 2 2 | 6 2.3|
Infiltration Cellular, Mixed Cell | 2 2 1 2 2 1 1 | 14 1.6|
Inflammation, Chronic | 1 | 1 1.0|
Metaplasia, Focal, Lipocyte | | 1 2.0|
Thrombosis | 3 | 1 3.0|
Bile Duct, Hyperplasia | 2 | 3 1.7|
Endothelial Cell, Hyperplasia, Focal | 1 | 2 1.5|
Endothelial Cell, Hyperplasia | | 1 2.0|
Hepatocyte, Cytomegaly | 1 2 1 1 3 1 2 2 2 1 2 1 3 1 2| 33 1.7|
Hepatocyte, Karyomegaly | 1 2 1 1 3 1 2 2 2 1 2 1 3 1 2| 33 1.8|
Hepatocyte, Necrosis, Focal | 3 2 3 2 | 6 2.2|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 2| 3| 3| 3| 2| 3| 2| 3| 8| 3| 2| 3| 3| 3| 6| 3| 3| 5| 2| 3| 3| |
| 0| 4| 6| 4| 9| 4| 4| 4| 9| 1| 0| 1| 9| 1| 9| 0| 0| 4| 1| 4| 0| 2| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Syncytial Alteration, | | |
Focal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 1 1 | 5 1.4|
Hepatocyte, Centrilobular, Necrosis | | 4 3.3|
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | | 1 2.0|
Hepatocyte, Midzonal, Vacuolization | | |
Cytoplasmic | 3 | 2 2.5|
Sinusoid, Dilatation, Diffuse | | 1 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + +| 14 |
Artery, Inflammation, Chronic, Focal | 1 | 2 1.5|
Fat, Necrosis | 2 3 | 3 2.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pigmentation, Focal | | 1 2.0|
Glands, Degeneration, Cystic, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + + + | 4 |
Peridontal Tissue, Inflammation, | | |
Chronic | 3 3 3 | 4 3.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | 1 1 | 3 1.0|
Mineralization, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 2| 3| 3| 3| 2| 3| 2| 3| 8| 3| 2| 3| 3| 3| 6| 3| 3| 5| 2| 3| 3| |
| 0| 4| 6| 4| 9| 4| 4| 4| 9| 1| 0| 1| 9| 1| 9| 0| 0| 4| 1| 4| 0| 2| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Artery, Inflammation, Chronic | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Cytoplasmic Alteration, Focal | 2 3 1 3 1 1 | 12 1.9|
Cytoplasmic Alteration | 3 | 2 3.5|
Hemorrhage | 4 | 1 4.0|
Hypertrophy | 2 | 2 2.0|
Bilateral, Capsule, Fibrosis | | 1 4.0|
Capsule, Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + M + + + + + + + + + + + + + +| 47 |
Angiectasis | 2 | 1 2.0|
Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M + M + + + M + + + + + + I| 46 |
Pars Distalis, Cyst | 1 | 2 1.5|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 1 2 | 7 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 2| 3| 3| 3| 2| 3| 2| 3| 8| 3| 2| 3| 3| 3| 6| 3| 3| 5| 2| 3| 3| |
| 0| 4| 6| 4| 9| 4| 4| 4| 9| 1| 0| 1| 9| 1| 9| 0| 0| 4| 1| 4| 0| 2| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 3 3 3 3 3 3 3 3| 21 3.0|
Inflammation, Chronic | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Prostate, NOS | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + +| 7 |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Plasma Cell | | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 2 3.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 3 2 2 3 2 2 3 3 2 | 20 2.7|
Hyperplasia, Lymphoid | | 3 2.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 2| 3| 3| 3| 2| 3| 2| 3| 8| 3| 2| 3| 3| 3| 6| 3| 3| 5| 2| 3| 3| |
| 0| 4| 6| 4| 9| 4| 4| 4| 9| 1| 0| 1| 9| 1| 9| 0| 0| 4| 1| 4| 0| 2| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Artery, Inflammation, Chronic, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + M + + + + + + + +| 43 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
Subcutaneous Tissue, Edema | 2 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vertebra, Hyperostosis, Focal | 2 3 3 3 3 3 3 3 3 2 3 3 2 3 2 3| 24 2.8|
|__________________________________________________________________________|____________|
Skeletal Muscle | +| 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 4 | 2 3.5|
Hemorrhage | 2 1 2 3 2 | 8 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 2| 3| 3| 3| 2| 3| 2| 3| 8| 3| 2| 3| 3| 3| 6| 3| 3| 5| 2| 3| 3| |
| 0| 4| 6| 4| 9| 4| 4| 4| 9| 1| 0| 1| 9| 1| 9| 0| 0| 4| 1| 4| 0| 2| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1.0 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Hyperplasia, Focal, Histiocytic | 2 | 1 2.0|
Hyperplasia, Histiocytic | 1 | 1 1.0|
Metaplasia, Focal, Osseous | 1 | 1 1.0|
Pigmentation, Focal | 2 1 | 2 1.5|
Alveolar Epithelium, Hyperplasia | 2 2 1 | 6 1.8|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 2 | 3 2.3|
Cyst | 1 2 2 | 7 1.6|
Metaplasia, Focal, Osseous | 1 1 2 1 1 | 10 1.4|
Nephropathy | 2 2 2 2 2 2 3 2 2 2 2 2 3 2 2 2 2 2 2 2 2 3 2 2 2| 50 2.1|
Glomerulus, Glomerulosclerosis | 1 2 2 1 3 2 3 2 1 2 2 2 1 1 2 1 2 3 1 1 1| 42 1.8|
Papilla, Necrosis | | 1 3.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 | 1 3.0|
Renal Tubule, Dilatation | 1 1 1 2 2 2 2 1 2 2 1 2 1 1 2 1 1 | 29 1.5|
Renal Tubule, Necrosis, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 3| 7| 5| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 8| 2| 3| 6| 3| 5| 3| 5| 0| 3| 6| 3| 8| 6| 3| 3| 3| 3| 2| 3| 4| 2| 3| 2| 1|
| 7| 7| 9| 4| 4| 6| 1| 0| 5| 0| 8| 3| 1| 0| 0| 1| 4| 1| 9| 4| 7| 9| 4| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A A + + + A A + + A + A + + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + A + + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + A + + + A|
|__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + A + + + A + + + + + + + A + + + A|
Edema | |
Hemorrhage, Focal | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + A + + + + + + + A + + + A|
Artery, Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + A + + + A + + + + + + + A + + + A|
|__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + A + + + + + + + A + + + A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Fibrosis, Focal | 3 2 2 |
Hemorrhage, Focal | 3 3 3 3 3 3 2 2 3 3|
Infiltration Cellular, Mixed Cell | 3 2 3 1 3 3 3 3 1 1 2 2 3 2 2 3 3|
Thrombosis | 3 3 3 3 |
Bile Duct, Hyperplasia | 2 3 |
Endothelial Cell, Hyperplasia | 2 |
Hepatocyte, Cytomegaly | 1 3 2 3 3 3 3 3 3 1 1 2 2 3 2 2 2 4 3 2 2 3 3|
Hepatocyte, Karyomegaly | 1 3 2 3 3 3 3 3 3 1 1 2 2 3 2 2 2 4 3 2 2 3 3|
Hepatocyte, Necrosis, Focal | 3 3 3 3 1 2 2 2 3|
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 1 |
Hepatocyte, Periportal, | |
Vacuolization Cytoplasmic | |
Hepatocyte, Centrilobular, Necrosis | 3 4 3 3 2 3 |
Hepatocyte, Centrilobular, | |
Vacuolization Cytoplasmic | 3 3 |
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 3| 7| 5| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 8| 2| 3| 6| 3| 5| 3| 5| 0| 3| 6| 3| 8| 6| 3| 3| 3| 3| 2| 3| 4| 2| 3| 2| 1|
| 7| 7| 9| 4| 4| 6| 1| 0| 5| 0| 8| 3| 1| 0| 0| 1| 4| 1| 9| 4| 7| 9| 4| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Serosa, Fibrosis | |
|__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation, Chronic, Focal | |
Fat, Necrosis | 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Tooth | + + + + |
Malformation | 2 2 |
Peridontal Tissue, Inflammation, | |
Chronic | 3 3 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 1 1 |
Mineralization, Focal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cytoplasmic Alteration, Focal | 2 2 2 2 1 2 1 1 |
Fibrosis | 2 |
Inflammation, Chronic, Focal | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 3| 7| 5| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 8| 2| 3| 6| 3| 5| 3| 5| 0| 3| 6| 3| 8| 6| 3| 3| 3| 3| 2| 3| 4| 2| 3| 2| 1|
| 7| 7| 9| 4| 4| 6| 1| 0| 5| 0| 8| 3| 1| 0| 0| 1| 4| 1| 9| 4| 7| 9| 4| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + M + + + + + + + M +|
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 3 3 3 2 3 3 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Prostate, NOS | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 3| 7| 5| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 8| 2| 3| 6| 3| 5| 3| 5| 0| 3| 6| 3| 8| 6| 3| 3| 3| 3| 2| 3| 4| 2| 3| 2| 1|
| 7| 7| 9| 4| 4| 6| 1| 0| 5| 0| 8| 3| 1| 0| 0| 1| 4| 1| 9| 4| 7| 9| 4| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node | + + |
Bronchial, Hyperplasia, Lymphoid | 2 |
Iliac, Hemorrhage | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + I + M + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | |
Inflammation, Granulomatous | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 3 3 3 3 3 3 2 2 3 3 2 2 3 3|
Necrosis, Focal | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + M +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + M|
Subcutaneous Tissue, Edema | 2 2 1 1 3 1 3 1 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Hyperostosis, Focal | 3 3 3 3 3 3 2 3 3 2 3 2 3 2 3 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 3| 7| 5| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 8| 2| 3| 6| 3| 5| 3| 5| 0| 3| 6| 3| 8| 6| 3| 3| 3| 3| 2| 3| 4| 2| 3| 2| 1|
| 7| 7| 9| 4| 4| 6| 1| 0| 5| 0| 8| 3| 1| 0| 0| 1| 4| 1| 9| 4| 7| 9| 4| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 1 |
Infiltration Cellular, Mixed Cell | 2 2 2 |
Thrombosis | 3 |
Alveolar Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
Hemorrhage, Focal | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 2 2 |
Cyst, Multiple | 2 |
Metaplasia, Focal, Osseous | 1 1 |
Nephropathy | 2 3 3 3 4 3 3 2 2 2 3 2 1 3 3 2 3 3 3 2 3 2 3 4 3|
Artery, Inflammation, Chronic | 2 |
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
_____________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 3| 7| 5| 7| 7| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 8| 2| 3| 6| 3| 5| 3| 5| 0| 3| 6| 3| 8| 6| 3| 3| 3| 3| 2| 3| 4| 2| 3| 2| 1|
| 7| 7| 9| 4| 4| 6| 1| 0| 5| 0| 8| 3| 1| 0| 0| 1| 4| 1| 9| 4| 7| 9| 4| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Capsule, Fibrosis | |
Glomerulus, Glomerulosclerosis | 3 2 3 3 3 2 2 2 3 2 3 2 3 2 3 2 2 3 3|
Pelvis, Dilatation | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 4 3 |
Renal Tubule, Dilatation | 2 2 2 2 1 2 2 2 2 1 2 2 |
Renal Tubule, Karyomegaly | 2 1 2 1 1 2|
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 85
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 7| 7| 7| 6| 6| 7| 5| 5| 6| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 5| 6| |
DAY ON TEST | 7| 7| 2| 9| 3| 2| 0| 0| 0| 3| 7| 6| 5| 0| 4| 5| 3| 8| 1| 2| 3| 2| 2| 9| 6| |
| 2| 5| 9| 8| 1| 9| 5| 3| 3| 1| 7| 6| 2| 5| 4| 9| 0| 5| 6| 9| 4| 9| 0| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + + + + + M A A + + M + + + + + +| 38 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + A A A + + + + + + A + + + + + + + + +| 42 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + A A A + + + + + + A + + + + + + + + +| 42 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + A A A + + + + + A A + + + + + + + + +| 39 |
Edema | 3 | 1 3.0|
Hemorrhage, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + A A A + + + + + A A + + + + + + + + +| 40 |
Artery, Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + A A A + + + + + A A + + + + + + + + +| 39 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + A A A + + + + + + A + + + + + + + + +| 41 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 | 3 2.0|
Fibrosis, Focal | 2 2 | 5 2.2|
Hemorrhage, Focal | 3 3 3 2 3 3 2 3 3 3 2 | 21 2.8|
Infiltration Cellular, Mixed Cell | 2 3 3 3 3 1 3 3 3 3 1 2 1 2 2| 32 2.3|
Thrombosis | 2| 5 2.8|
Bile Duct, Hyperplasia | 2 2 2 3 | 6 2.3|
Endothelial Cell, Hyperplasia | | 1 2.0|
Hepatocyte, Cytomegaly | 2 3 3 2 3 3 3 2 3 2 3 2 3 3 3 3 2 2 2 3| 43 2.5|
Hepatocyte, Karyomegaly | 2 3 3 2 3 3 3 2 3 2 3 2 3 3 3 3 2 2 2 3| 43 2.5|
Hepatocyte, Necrosis, Focal | 2 3 2 3 3 3 3 3 3 2 3 3| 21 2.6|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | | 1 1.0|
Hepatocyte, Periportal, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 7| 7| 7| 6| 6| 7| 5| 5| 6| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 5| 6| |
DAY ON TEST | 7| 7| 2| 9| 3| 2| 0| 0| 0| 3| 7| 6| 5| 0| 4| 5| 3| 8| 1| 2| 3| 2| 2| 9| 6| |
| 2| 5| 9| 8| 1| 9| 5| 3| 3| 1| 7| 6| 2| 5| 4| 9| 0| 5| 6| 9| 4| 9| 0| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Vacuolization Cytoplasmic | 3 | 1 3.0|
Hepatocyte, Centrilobular, Necrosis | 3 3 3 3 | 10 3.0|
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | 3 | 3 3.0|
Serosa, Fibrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Artery, Inflammation, Chronic, Focal | 2 | 1 2.0|
Fat, Necrosis | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + A + + + + + + + + +| 48 |
Acinus, Atrophy, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + A + + + + + + + + A + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Tooth | | 4 |
Malformation | | 2 2.0|
Peridontal Tissue, Inflammation, | | |
Chronic | | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | 2 | 3 1.3|
Mineralization, Focal | 2 1 2 | 4 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 7| 7| 7| 6| 6| 7| 5| 5| 6| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 5| 6| |
DAY ON TEST | 7| 7| 2| 9| 3| 2| 0| 0| 0| 3| 7| 6| 5| 0| 4| 5| 3| 8| 1| 2| 3| 2| 2| 9| 6| |
| 2| 5| 9| 8| 1| 9| 5| 3| 3| 1| 7| 6| 2| 5| 4| 9| 0| 5| 6| 9| 4| 9| 0| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Cortex | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 1 1 | 2 1.0|
Cytoplasmic Alteration, Focal | 1 1 1 1 1 3 2 1 1 1| 18 1.4|
Fibrosis | | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + + + + + + A + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + M + + +| 45 |
Cyst | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | M + + M + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Cyst | 2 1 | 3 1.3|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 3 | 7 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 3 3 3 3 3 3 3 3 3| 19 2.9|
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 7| 7| 7| 6| 6| 7| 5| 5| 6| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 5| 6| |
DAY ON TEST | 7| 7| 2| 9| 3| 2| 0| 0| 0| 3| 7| 6| 5| 0| 4| 5| 3| 8| 1| 2| 3| 2| 2| 9| 6| |
| 2| 5| 9| 8| 1| 9| 5| 3| 3| 1| 7| 6| 2| 5| 4| 9| 0| 5| 6| 9| 4| 9| 0| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Prostate, NOS | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 1 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + +| 4 |
Bronchial, Hyperplasia, Lymphoid | | 1 2.0|
Iliac, Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M M + + M + + + + + + + +| 44 |
Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Hemorrhage | 4 | 2 3.0|
Hyperplasia, Lymphoid | 4 2 2 | 4 2.8|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Granulomatous | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 3 2 3 3 3 3 3 3 3 3 3 4 2 3 3 2 | 33 2.8|
Necrosis, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | M + + + + + + + M + + + M + + + M + + + + + + + M| 43 |
Cyst | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 7| 7| 7| 6| 6| 7| 5| 5| 6| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 5| 6| |
DAY ON TEST | 7| 7| 2| 9| 3| 2| 0| 0| 0| 3| 7| 6| 5| 0| 4| 5| 3| 8| 1| 2| 3| 2| 2| 9| 6| |
| 2| 5| 9| 8| 1| 9| 5| 3| 3| 1| 7| 6| 2| 5| 4| 9| 0| 5| 6| 9| 4| 9| 0| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M +| 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Subcutaneous Tissue, Edema | 3 3 1 1 2 3 3 2 3 2 1 3 1 2 1 2| 25 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vertebra, Hyperostosis, Focal | 3 3 3 3 3 3 3 2 3 3 3 3| 27 2.8|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 2 2.5|
Hemorrhage | 2 2 | 3 1.7|
Infiltration Cellular, Mixed Cell | 2 | 4 2.0|
Thrombosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 1 2 | 3 1.3|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05161-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RIDDELLIINE Date: 09/04/01
Route: GAVAGE Time: 09:06:02
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 7| 7| 7| 6| 6| 7| 5| 5| 6| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 5| 6| |
DAY ON TEST | 7| 7| 2| 9| 3| 2| 0| 0| 0| 3| 7| 6| 5| 0| 4| 5| 3| 8| 1| 2| 3| 2| 2| 9| 6| |
| 2| 5| 9| 8| 1| 9| 5| 3| 3| 1| 7| 6| 2| 5| 4| 9| 0| 5| 6| 9| 4| 9| 0| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
3.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG/DY | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
Hemorrhage, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Eye | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Cyst | 2 2 | 4 2.0|
Cyst, Multiple | | 1 2.0|
Metaplasia, Focal, Osseous | 1 1 | 4 1.0|
Nephropathy | 3 3 3 2 3 3 3 3 3 2 1 3 4 3 3 2 4 4 3 3 2 3 4 3 2| 50 2.8|
Artery, Inflammation, Chronic | 3 | 2 2.5|
Capsule, Fibrosis | 3 | 1 3.0|
Glomerulus, Glomerulosclerosis | 2 3 3 1 3 3 3 3 2 2 3 2 3 3 3 3 2 3 2 3 1 1| 41 2.5|
Pelvis, Dilatation | 2 | 1 2.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 2 | 3 3.0|
Renal Tubule, Dilatation | 2 2 2 2 2 1 2 3 2 2| 22 1.9|
Renal Tubule, Karyomegaly | 2 1 1 1 1 2 | 12 1.4|
Renal Tubule, Pigmentation | 1 3 | 2 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------