TDMS Study 05161-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst RIDDELLIINE DATE: 11/30/00
EXPERIMENT: 05161 TEST: 06 TIME: 08:19:53
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55393 ROUTE: GAVAGE NTP C#: 61358C
PATHOLOGIST: FARNELL, D. CAS: 23246-96-0
------------------------------------------------------------------------------------------------------------------------------------
MICE/FINAL#1
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst RIDDELLIINE DATE: 11/30/00
EXPERIMENT: 05161 TEST: 06 TIME: 08:19:53
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: GAVAGE NTP C#: 61358C
PATHOLOGIST: FARNELL, D. CAS: 23246-96-0
RIDDELLIINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 1 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 475 486 561 599 633 637 675 706 713 713 |
| CENSORED DEATHS |
| 188 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 434 542 566 587 596 633 634 681 696 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.3 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 567 592 614 619 657 700 713 720 722 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
RIDDELLIINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.0 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 507 531 552 554 566 582 639 661 661 689 |
| 707 720 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3.0 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 356 550 559 566 568 572 577 587 590 598 |
| 603 603 605 614 633 639 644 647 652 660 |
| 661 664 675 681 685 705 705 716 720 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
RIDDELLIINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 98.0 95.9 91.8 87.8 79.6 |
|MG/KG/DY | |
| | |
|0.1 | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 86.0 82.0 |
|MG/KG/DY | |
| | |
|0.3 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 90.0 80.0 |
|MG/KG/DY | |
| | |
|1.0 | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 88.0 82.0 76.0 |
|MG/KG/DY | |
| | |
|3.0 | 100.0 100.0 100.0 98.0 98.0 98.0 98.0 74.0 56.0 40.0 |
|MG/KG/DY | |
| | |
==================================================================================
RIDDELLIINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 0.1 0.3 1.0 3.0 |
| MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 79.6% 82.0% 80.0% 76.0% 40.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.989N P=1.000N P=0.819 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 619.8 596.6 663.2 614.1 625.4 |
|NATURAL DEATHS (C) | (28.1) (26.4) (19.3) (21.3) (13.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 696.3 705.2 715.8 701.4 666.8 |
|(STANDARD ERROR) | (13.2) ( 8.6) ( 5.3) ( 8.6) (10.8) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
RIDDELLIINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 4 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 27 419 475 482 524 566 577 657 675 696 |
| 709 725 |
| CENSORED DEATHS |
| 545 545 545 545 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3.0 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 434 489 504 530 532 587 591 596 618 637 |
| 637 656 660 669 675 675 681 692 696 696 |
| 696 696 700 709 709 709 709 713 716 720 |
| 720 722 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
RIDDELLIINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 98.0 98.0 98.0 98.0 96.0 92.0 90.0 85.6 83.4 74.6 |
|MG/KG/DY | |
| | |
|3.0 | 100.0 100.0 100.0 100.0 100.0 98.0 90.0 84.0 74.0 34.0 |
|MG/KG/DY | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 3.0 |
| MG/KG/DY MG/KG/DY |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.6% 34.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 544.3 651.4 |
|NATURAL DEATHS (C) | (55.5) (13.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 670.0 677.8 |
|(STANDARD ERROR) | (17.8) (10.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
RIDDELLIINE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG/DY = 1
0.1 MG/KG/DY = 2
0.3 MG/KG/DY = 3
1.0 MG/KG/DY = 4
3.0 MG/KG/DY = 5
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 5 2 1 4 3
| 5 2 1 1 4 4 25 3 3
| 1 4 2441 2 31 33
| 445 2 1 3 1 3
P 90 + 4 4 2 2 3 3
E | 554 14 1 3 3
R | 55 5 24 4 12 21333
C | 55 4 4211 2
E 80 + 55 4 41 3 1
N | 4 4
T | 55 4 4
| 5 5
S 70 + 55
U |
R | 555
V | 5 5
I 60 +
V |
A | 5 55
L |
50 + 5 5
|
| 5 5
| 55
40 + 5 5
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 21 obs hidden.
RIDDELLIINE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG/DY = 1
3.0 MG/KG/DY = 2
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2
| 1 1 2 2
| 1 112 2 2
| 1 1
90 + 12 1 2
| 1 12 2
P | 1 22 2 1
E | 2 2 1 1
R 80 + 1 1 1
C | 2 2 1 1
E | 2 22 1 1
N | 22
T 70 +
| 22
S | 222
U |
R 60 +
V |
I | 2 2
V |
A 50 +
L |
| 22
|
40 +
| 22
| 2 2
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.