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TDMS Study 05162-09 Pathology Tables

NTP  EXP/TEST: 05162-09                                  DIETHANOLAMINE                                           PAGE: 1
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 04/08/96
ROUTE: SKIN APPLICATION                                                                                           TIME: 08:46:25

                                                         EIS REPORT 37


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  55174D

       CONTRACT NUMBER:  N01-ES-05293

       CAS NUMBER:  111-42-2

       ANIMAL SUPPLIER:  NOT SPECIFIED

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL
NTP  EXP/TEST: 05162-09                                  DIETHANOLAMINE                                           PAGE: 2
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 04/08/96
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:46:25
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 2                      ROOM/AREA:    229         FIRST DOSE: 10/08/90
            SEX: FEMALE                               TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

214         214  506 02/25/92   646 07/14/92   6/6   Irritation Site of Applic

246         246  478 01/28/92   646 07/14/92   7/24  Irritation Site of Applic
NTP  EXP/TEST: 05162-09                                  DIETHANOLAMINE                                           PAGE: 3
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 04/08/96
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:46:25
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 4                      ROOM/AREA:    229         FIRST DOSE: 10/08/90
            SEX: FEMALE                               TRT: 8 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

260         260  394 11/05/91   674 08/11/92  11/25  Irritation Site of Applic

261         261  590 05/19/92   646 07/14/92   2/24  Irritation Site of Applic
NTP  EXP/TEST: 05162-09                                  DIETHANOLAMINE                                           PAGE: 4
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 04/08/96
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:46:25
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 6                      ROOM/AREA:    229         FIRST DOSE: 10/08/90
            SEX: FEMALE                               TRT: 16 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

317         317  450 12/31/91   450 12/31/91   1/18  Irritation Site of Applic

332         332  506 02/25/92   674 08/11/92   6/25  Irritation Site of Applic
NTP  EXP/TEST: 05162-09                                  DIETHANOLAMINE                                           PAGE: 5
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 04/08/96
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:46:25
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 8                      ROOM/AREA:    229         FIRST DOSE: 10/08/90
            SEX: FEMALE                               TRT: 32 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

355         355  422 12/03/91   422 12/03/91   1/18  Irritation Site of Applic

356         356  617 06/15/92   617 06/15/92   1/23  Irritation Site of Applic

358         358  450 12/31/91   646 07/14/92   7/24  Irritation Site of Applic

366         366  394 11/05/91   394 11/05/91   1/27  Irritation Site of Applic

368         368  338 09/10/91   422 12/03/91   4/16  Irritation Site of Applic

384         384  450 12/31/91   674 08/11/92   9/27  Irritation Site of Applic

391         391  450 12/31/91   450 12/31/91   1/21  Irritation Site of Applic

397         397  366 10/08/91   478 01/28/92   3/26  Irritation Site of Applic
NTP  EXP/TEST: 05162-09                                  DIETHANOLAMINE                                           PAGE: 6
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 04/08/96
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:46:25
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 1                      ROOM/AREA:    229         FIRST DOSE: 10/08/90
            SEX: MALE                                 TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.
NTP  EXP/TEST: 05162-09                                  DIETHANOLAMINE                                           PAGE: 7
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 04/08/96
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:46:25
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 3                      ROOM/AREA:    229         FIRST DOSE: 10/08/90
            SEX: MALE                                 TRT: 16 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

53           53  393 11/04/91   722 09/28/92   4/27  Irritation Site of Applic
NTP  EXP/TEST: 05162-09                                  DIETHANOLAMINE                                           PAGE: 8
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 04/08/96
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:46:25
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 5                      ROOM/AREA:    229         FIRST DOSE: 10/08/90
            SEX: MALE                                 TRT: 32 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.
NTP  EXP/TEST: 05162-09                                  DIETHANOLAMINE                                           PAGE: 9
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 04/08/96
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:46:25
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 7                      ROOM/AREA:    229         FIRST DOSE: 10/08/90
            SEX: MALE                                 TRT: 64 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- --------------------

183         183  449 12/30/91   449 12/30/91   1/19  Irritation Site of Applic

187         187  197 04/22/91   309 08/12/91   3/23  Irritation Site of Applic

191         191  309 08/12/91   309 08/12/91   1/17  Irritation Site of Applic

198         198  589 05/18/92   589 05/18/92   1/27  Irritation Site of Applic

                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
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