TDMS Study 05162-09 Pathology Tables
NTP Experiment-Test: 05162-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHANOLAMINE Date: 04/08/96
Route: SKIN APPLICATION Time: 09:29:59
CORE STUDY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 111-42-2
Lock Date: 05/07/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05162-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHANOLAMINE Date: 04/08/96
Route: SKIN APPLICATION Time: 09:29:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 8 MG/KG 16 MG/KG 32 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 14 5 9 13
Moribund Sacrifice 11 16 12 13
Survivors
Terminal Sacrifice 25 29 29 24
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Periesophageal Tissue, Necrosis 1 (2%)
Intestine Large, Colon (50) (50) (50) (49)
Mineralization 1 (2%)
Parasite Metazoan 3 (6%) 3 (6%) 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
Parasite Metazoan 4 (8%) 1 (2%)
Ulcer 1 (2%)
Intestine Large, Cecum (50) (49) (50) (49)
Parasite Metazoan 1 (2%)
Ulcer 1 (2%) 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (49)
Mineralization 1 (2%)
Ulcer 1 (2%) 2 (4%)
Intestine Small, Ileum (49) (49) (48) (47)
Muscularis, Inflammation, Chronic Active,
Focal 1 (2%)
Liver (50) (50) (50) (50)
Basophilic Focus 40 (80%) 31 (62%) 20 (40%) 7 (14%)
Clear Cell Focus 3 (6%) 2 (4%) 1 (2%)
Congestion 1 (2%)
Cyst 2 (4%)
Degeneration, Cystic 2 (4%)
Eosinophilic Focus 1 (2%) 5 (10%) 2 (4%) 3 (6%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%)
Hepatodiaphragmatic Nodule 2 (4%) 6 (12%) 6 (12%) 8 (16%)
Mixed Cell Focus 3 (6%) 6 (12%) 1 (2%)
Necrosis 1 (2%)
Centrilobular, Degeneration 1 (2%) 2 (4%)
Centrilobular, Necrosis 2 (4%) 1 (2%)
Oval Cell, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05162-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHANOLAMINE Date: 04/08/96
Route: SKIN APPLICATION Time: 09:29:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 8 MG/KG 16 MG/KG 32 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Periportal, Degeneration 1 (2%)
Portal, Fibrosis 1 (2%)
Serosa, Fibrosis 1 (2%)
Mesentery (4) (7) (6) (5)
Angiectasis 1 (20%)
Inflammation, Chronic 1 (17%)
Fat, Necrosis 4 (100%) 6 (86%) 4 (67%) 3 (60%)
Oral Mucosa (2) (2) (1)
Gingival, Inflammation, Suppurative 2 (100%) 1 (50%)
Pancreas (50) (50) (50) (50)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%) 1 (2%)
Acinus, Atrophy 13 (26%) 21 (42%) 11 (22%) 14 (28%)
Artery, Inflammation, Chronic Active 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Inflammation, Chronic Active 2 (4%)
Mineralization 1 (2%)
Ulcer 2 (4%) 3 (6%) 5 (10%) 6 (12%)
Epithelium, Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Hyperplasia 1 (2%)
Mineralization 2 (4%)
Ulcer 3 (6%) 2 (4%) 2 (4%) 2 (4%)
Tongue (1) (1) (1)
Inflammation, Suppurative 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2)
Mineralization 2 (100%)
Heart (50) (50) (50) (50)
Atrium, Thrombosis 1 (2%) 1 (2%) 4 (8%) 1 (2%)
Myocardium, Degeneration 36 (72%) 33 (66%) 35 (70%) 36 (72%)
Myocardium, Mineralization 3 (6%)
Valve, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hyperplasia 13 (26%) 13 (26%) 11 (22%) 11 (22%)
Hypertrophy 1 (2%) 2 (4%) 2 (4%)
Necrosis, Acute 1 (2%)
Thrombosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05162-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHANOLAMINE Date: 04/08/96
Route: SKIN APPLICATION Time: 09:29:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 8 MG/KG 16 MG/KG 32 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Bilateral, Hypertrophy 1 (2%)
Adrenal Medulla (49) (50) (49) (50)
Hyperplasia 3 (6%) 10 (20%) 4 (8%) 10 (20%)
Necrosis 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (43) (42) (42) (49)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (49) (50) (50) (50)
Angiectasis 1 (2%)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Degeneration, Cystic 5 (10%) 3 (6%) 2 (4%) 4 (8%)
Pars Distalis, Hyperplasia 3 (6%) 11 (22%) 12 (24%) 5 (10%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 31 (62%) 33 (66%) 39 (78%) 29 (58%)
Follicular Cell, Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (49) (47)
Fibrosis 1 (2%)
Hyperplasia 4 (8%) 4 (8%) 1 (2%) 2 (4%)
Inflammation, Suppurative 3 (6%) 4 (8%) 1 (2%) 1 (2%)
Ovary (50) (50) (50) (50)
Cyst 4 (8%) 4 (8%) 5 (10%) 8 (16%)
Necrosis 1 (2%)
Uterus (50) (50) (50) (50)
Atrophy 1 (2%)
Necrosis 1 (2%)
Prolapse 1 (2%)
Endometrium, Hyperplasia, Cystic 1 (2%) 1 (2%) 1 (2%)
Epithelium, Hypertrophy 1 (2%)
Vagina (2) (1) (1)
Infiltration Cellular, Polymorphonuclear 2 (100%)
Inflammation, Chronic 1 (100%)
Muscularis, Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05162-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHANOLAMINE Date: 04/08/96
Route: SKIN APPLICATION Time: 09:29:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 8 MG/KG 16 MG/KG 32 MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Atrophy 1 (2%)
Hyperplasia 2 (4%) 6 (12%) 4 (8%) 5 (10%)
Myelofibrosis 1 (2%)
Necrosis 1 (2%)
Lymph Node, Mandibular (50) (49) (50) (48)
Atrophy 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (49)
Atrophy 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic Active 1 (2%)
Spleen (50) (50) (50) (50)
Fibrosis 1 (2%) 3 (6%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 3 (6%) 4 (8%) 1 (2%)
Necrosis 1 (2%)
Capsule, Pigmentation, Focal, Hemosiderin 1 (2%)
Lymphoid Follicle, Atrophy 2 (4%) 1 (2%) 1 (2%)
Lymphoid Follicle, Hyperplasia 1 (2%)
Thymus (49) (49) (47) (48)
Atrophy 1 (2%)
Cyst 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Epidermis, Fibrosis 1 (2%)
Epidermis, Skin, Site of Application,
Acanthosis 1 (2%) 1 (2%) 4 (8%) 6 (12%)
Epidermis, Skin, Site of Application, Exudate 1 (2%) 7 (14%) 7 (14%) 7 (14%)
Epidermis, Skin, Site of Application,
Hyperkeratosis 3 (6%) 13 (26%) 23 (46%) 23 (46%)
Skin, Site of Application, Ulcer 2 (4%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05162-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHANOLAMINE Date: 04/08/96
Route: SKIN APPLICATION Time: 09:29:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 8 MG/KG 16 MG/KG 32 MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 5 (10%) 2 (4%) 5 (10%) 5 (10%)
Fibrosis, Focal 1 (2%)
Inflammation, Granulomatous 3 (6%) 3 (6%) 5 (10%) 9 (18%)
Mineralization 2 (4%)
Alveolar Epithelium, Hyperplasia 2 (4%) 3 (6%) 2 (4%) 2 (4%)
Interstitium, Inflammation, Chronic 2 (4%) 2 (4%)
Nose (49) (50) (50) (50)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Pleura (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (2)
Cataract 1 (50%) 1 (50%)
Degeneration 1 (50%)
Anterior Chamber, Inflammation, Suppurative 1 (100%)
Retina, Atrophy 1 (50%)
Harderian Gland (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 1 (2%)
Nephropathy 40 (80%) 47 (94%) 48 (96%) 48 (96%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Mineralization 1 (2%) 1 (2%)
Renal Tubule, Pigmentation, Hemosiderin 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05162-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHANOLAMINE Date: 04/08/96
Route: SKIN APPLICATION Time: 09:29:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 16 MG/KG 32 MG/KG 64 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 31 31 25 22
Natural Death 5 9 4 6
Survivors
Terminal Sacrifice 14 10 21 22
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Parasite Metazoan 2 (4%) 3 (6%) 3 (6%)
Ulcer 1 (2%)
Intestine Large, Rectum (50) (50) (50) (49)
Parasite Metazoan 4 (8%) 2 (4%) 4 (8%) 3 (6%)
Ulcer 1 (2%)
Intestine Large, Cecum (50) (50) (50) (50)
Inflammation, Acute 1 (2%)
Parasite Metazoan 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (50)
Ulcer 3 (6%) 1 (2%)
Intestine Small, Jejunum (50) (46) (48) (48)
Diverticulum 1 (2%)
Ulcer 1 (2%)
Muscularis, Inflammation, Chronic 1 (2%)
Liver (50) (50) (50) (50)
Basophilic Focus 15 (30%) 5 (10%) 1 (2%) 2 (4%)
Clear Cell Focus 1 (2%) 3 (6%) 2 (4%)
Degeneration, Cystic 2 (4%) 2 (4%) 5 (10%) 2 (4%)
Degeneration, Fatty 6 (12%) 5 (10%) 9 (18%) 7 (14%)
Eosinophilic Focus 4 (8%) 2 (4%) 2 (4%) 2 (4%)
Hepatodiaphragmatic Nodule 6 (12%) 1 (2%) 8 (16%) 4 (8%)
Mixed Cell Focus 1 (2%) 1 (2%)
Necrosis 2 (4%) 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Centrilobular, Degeneration 3 (6%) 1 (2%) 2 (4%) 1 (2%)
Centrilobular, Necrosis 1 (2%) 1 (2%)
Midzonal, Vacuolization Cytoplasmic 1 (2%)
Sinusoid, Congestion 1 (2%)
Mesentery (7) (4) (8) (3)
Hemorrhage 1 (14%)
Artery, Inflammation, Chronic 1 (13%)
Artery, Thrombosis 2 (29%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05162-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHANOLAMINE Date: 04/08/96
Route: SKIN APPLICATION Time: 09:29:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 16 MG/KG 32 MG/KG 64 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis 4 (57%) 3 (75%) 4 (50%) 3 (100%)
Oral Mucosa (7) (2) (2)
Inflammation, Suppurative 4 (57%) 1 (50%)
Gingival, Inflammation, Suppurative 2 (29%) 2 (100%)
Pancreas (50) (50) (50) (50)
Acinus, Atrophy 23 (46%) 18 (36%) 26 (52%) 24 (48%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
Artery, Thrombosis 1 (2%) 1 (2%)
Duct, Atrophy 1 (2%)
Salivary Glands (50) (49) (50) (50)
Inflammation, Chronic 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic 4 (8%) 1 (2%) 2 (4%) 2 (4%)
Mineralization 1 (2%) 1 (2%)
Ulcer 7 (14%) 8 (16%) 9 (18%) 10 (20%)
Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Mineralization 4 (8%) 3 (6%) 2 (4%) 1 (2%)
Ulcer 7 (14%) 4 (8%) 5 (10%) 4 (8%)
Tongue (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (4) (3) (1)
Mineralization 4 (100%) 3 (100%)
Heart (50) (50) (50) (50)
Degeneration, Fatty 1 (2%)
Atrium, Thrombosis 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Myocardium, Degeneration 41 (82%) 41 (82%) 44 (88%) 45 (90%)
Myocardium, Mineralization 1 (2%) 1 (2%) 1 (2%)
Valve, Degeneration 1 (2%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Atrophy 1 (2%)
Hyperplasia 16 (32%) 15 (30%) 15 (30%) 12 (24%)
Hypertrophy 2 (4%)
Necrosis 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Degeneration, Cystic 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05162-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHANOLAMINE Date: 04/08/96
Route: SKIN APPLICATION Time: 09:29:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 16 MG/KG 32 MG/KG 64 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 11 (22%) 9 (18%) 15 (30%) 8 (16%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 2 (4%) 4 (8%) 5 (10%) 4 (8%)
Parathyroid Gland (46) (49) (48) (47)
Hyperplasia 2 (4%) 9 (18%) 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (50) (49)
Cyst 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Pars Distalis, Degeneration, Cystic 2 (4%) 2 (4%) 2 (4%)
Pars Distalis, Hyperplasia 4 (8%) 8 (16%) 7 (14%) 8 (16%)
Pars Distalis, Hypoplasia 1 (2%)
Thyroid Gland (50) (50) (50) (49)
Cyst 1 (2%) 1 (2%)
Bilateral, Follicular Cell, Cyst 1 (2%)
C-Cell, Hyperplasia 33 (66%) 37 (74%) 42 (84%) 33 (67%)
Follicular Cell, Cyst 2 (4%) 2 (4%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Arteriole, Inflammation, Chronic 1 (2%)
Preputial Gland (50) (50) (49) (50)
Hyperplasia 3 (6%) 1 (2%) 2 (4%)
Inflammation, Granulomatous 2 (4%) 5 (10%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Prostate (50) (50) (50) (50)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 2 (4%)
Inflammation, Suppurative 2 (4%) 6 (12%) 3 (6%) 4 (8%)
Necrosis 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Atrophy 2 (4%)
Fibrosis 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Testes (50) (50) (50) (50)
Germinal Epithelium, Atrophy 16 (32%) 10 (20%) 11 (22%) 9 (18%)
Interstitial Cell, Hyperplasia 2 (4%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05162-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHANOLAMINE Date: 04/08/96
Route: SKIN APPLICATION Time: 09:29:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 16 MG/KG 32 MG/KG 64 MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Fibrosis 1 (2%)
Hyperplasia 10 (20%) 4 (8%) 7 (14%) 9 (18%)
Lymph Node (4) (4) (5) (2)
Mediastinal, Ectasia 1 (50%)
Mediastinal, Hematopoietic Cell Proliferation 1 (25%)
Renal, Infiltration Cellular, Plasma Cell 1 (20%)
Lymph Node, Mandibular (49) (48) (50) (49)
Atrophy 1 (2%)
Erythrophagocytosis 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Acute 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Congestion 1 (2%)
Ectasia 2 (4%) 1 (2%) 1 (2%)
Erythrophagocytosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Necrosis 1 (2%)
Spleen (50) (50) (50) (50)
Congestion 1 (2%) 1 (2%) 3 (6%)
Fibrosis 7 (14%) 10 (20%) 9 (18%) 2 (4%)
Hematopoietic Cell Proliferation 2 (4%) 3 (6%) 1 (2%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 3 (6%) 1 (2%) 1 (2%)
Lymphoid Follicle, Atrophy 1 (2%) 2 (4%)
Lymphoid Follicle, Necrosis 1 (2%)
Thymus (47) (48) (48) (47)
Atrophy 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (48) (45) (42)
Hyperplasia, Cystic 5 (11%) 5 (10%) 5 (11%) 1 (2%)
Duct, Dilatation 1 (2%)
Skin (50) (50) (50) (50)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Dermis, Skin, Site of Application, Fibrosis 1 (2%) 1 (2%)
Epidermis, Skin, Site of Application,
Acanthosis 2 (4%) 4 (8%) 10 (20%)
Epidermis, Skin, Site of Application,
Degeneration 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05162-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHANOLAMINE Date: 04/08/96
Route: SKIN APPLICATION Time: 09:29:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 16 MG/KG 32 MG/KG 64 MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Epidermis, Skin, Site of Application, Erosion 1 (2%)
Epidermis, Skin, Site of Application, Exudate 3 (6%) 2 (4%) 7 (14%)
Epidermis, Skin, Site of Application,
Hyperkeratosis 3 (6%) 5 (10%) 11 (22%)
Skin, Site of Application, Ulcer 2 (4%)
Subcutaneous Tissue, Inflammation, Focal,
Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Cyst 1 (2%)
Fibrous Osteodystrophy 3 (6%) 4 (8%) 4 (8%)
Vertebra, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Degeneration 1 (2%)
Choroid Plexus, Thrombosis 1 (2%)
Medulla, Demyelination, Focal 1 (2%)
Medulla, Necrosis, Focal 2 (4%)
Spinal Cord (2) (1) (1)
Gliosis 1 (100%)
Neuron, Degeneration 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 1 (2%) 3 (6%)
Hemorrhage, Focal 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Granulomatous 5 (10%) 2 (4%) 2 (4%)
Mineralization 3 (6%) 1 (2%)
Alveolar Epithelium, Hyperplasia 5 (10%) 2 (4%) 2 (4%)
Bronchus, Infiltration Cellular, Mononuclear
Cell 1 (2%)
Bronchus, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Interstitium, Inflammation, Chronic 3 (6%) 1 (2%) 2 (4%)
Nose (50) (50) (50) (49)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 2 (4%) 5 (10%) 4 (8%) 9 (18%)
Glands, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05162-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIETHANOLAMINE Date: 04/08/96
Route: SKIN APPLICATION Time: 09:29:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 16 MG/KG 32 MG/KG 64 MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (2)
Cataract 1 (50%) 2 (100%)
Degeneration 1 (50%)
Lens, Cataract 2 (100%)
Harderian Gland (3)
Inflammation, Acute 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 1 (2%)
Cyst 3 (6%) 3 (6%) 2 (4%) 2 (4%)
Hydronephrosis 1 (2%)
Infarct 2 (4%)
Inflammation, Acute 1 (2%)
Nephropathy 48 (96%) 48 (96%) 50 (100%) 48 (96%)
Urinary Bladder (48) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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