https://ntp.niehs.nih.gov/go/1533

TDMS Study 05162-09 Pathology Tables

NTP Experiment-Test: 05162-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96
Route: SKIN APPLICATION                                                                                           Time: 09:58:44
                                                           CORE STUDY
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  111-42-2
       Lock Date:  05/07/93
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 05162-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:58:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      8 MG/KG      16 MG/KG     32 MG/KG                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     14            5            9           13                                     
    Moribund Sacrifice                                11           16           12           13                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           29           29           24                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Colon                             (50)         (50)         (50)         (49)                                   
   Intestine Large, Cecum                             (50)         (49)         (50)         (49)                                   
   Intestine Small, Duodenum                          (50)         (50)         (50)         (49)                                   
   Intestine Small, Jejunum                           (48)         (49)         (49)         (46)                                   
   Intestine Small, Ileum                             (49)         (49)         (48)         (47)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma                                                                1 (2%)                                
      Hepatocellular Adenoma                           1 (2%)       1 (2%)                                                          
   Mesentery                                          (4)          (7)          (6)          (5)                                    
      Yolk Sac Carcinoma, Metastatic, Ovary                                                   1 (20%)                               
   Oral Mucosa                                        (2)          (2)                       (1)                                    
      Squamous Cell Carcinoma                                       1 (50%)                   1 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)                                   
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                    1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Adrenal Medulla                                    (49)         (50)         (49)         (50)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Pheochromocytoma Benign                                       1 (2%)       2 (4%)       2 (4%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Carcinoma                                                                               1 (2%)                                
                                                             Page   2                                                               
NTP Experiment-Test: 05162-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:58:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      8 MG/KG      16 MG/KG     32 MG/KG                                  
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (49)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          25 (51%)     27 (54%)     30 (60%)     33 (66%)                               
      Pars Distalis, Adenoma, Multiple                 2 (4%)       4 (8%)       1 (2%)       1 (2%)                                
      Pars Distalis, Carcinoma                         2 (4%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  8 (16%)      8 (16%)      6 (12%)      5 (10%)                               
      C-Cell, Carcinoma                                             1 (2%)                    2 (4%)                                
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Clitoral Gland                                     (50)         (50)         (49)         (47)                                   
      Adenoma                                          4 (8%)       5 (10%)      2 (4%)                                             
      Adenoma, Multiple                                             1 (2%)                                                          
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Yolk Sac Carcinoma                                                                      1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Polyp Stromal                                    3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
      Sarcoma Stromal                                  1 (2%)                    1 (2%)       1 (2%)                                
      Yolk Sac Carcinoma, Metastatic, Ovary                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (1)          (3)          (3)          (3)                                    
      Inguinal, Yolk Sac Carcinoma, Metastatic,                                                                                     
           Ovary                                                                              1 (33%)                               
      Mediastinal, Yolk Sac Carcinoma, Metastatic,                                                                                  
           Ovary                                                                              1 (33%)                               
   Lymph Node, Mandibular                             (50)         (49)         (50)         (48)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Thymus                                             (49)         (49)         (47)         (48)                                   
      Thymoma Benign                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05162-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:58:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      8 MG/KG      16 MG/KG     32 MG/KG                                  
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                                  1 (2%)                                             
      Carcinoma, Multiple                                                                     1 (2%)                                
      Fibroadenoma                                    13 (26%)      6 (12%)      9 (18%)      4 (8%)                                
      Fibroadenoma, Multiple                           1 (2%)       2 (4%)                    1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Fibrosarcoma                                     1 (2%)                                                                       
      Schwannoma Malignant                                          1 (2%)                                                          
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Trichoepithelioma                                             1 (2%)                                                          
      Conjunctiva, Schwannoma Malignant                             1 (2%)                                                          
      Skin, Site of Application, Keratoacanthoma                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
      Osteosarcoma                                                                            1 (2%)                                
   Skeletal Muscle                                                                           (1)                                    
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (50)         (49)         (50)         (50)                                   
      Astrocytoma Malignant                            1 (2%)                                                                       
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Medulla, Carcinoma, Metastatic, Pituitary                                                                                     
          Gland                                        1 (2%)                                                                       
   Spinal Cord                                                                               (1)                                    
      Glioma Malignant                                                                        1 (100%)                              
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)                                                                       
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                              1 (2%)                                
      Yolk Sac Carcinoma, Metastatic, Ovary                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05162-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:58:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      8 MG/KG      16 MG/KG     32 MG/KG                                  
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Zymbal's Gland                                     (2)                       (1)                                                 
      Carcinoma                                        2 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Papilloma                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            11 (22%)     13 (26%)     10 (20%)     13 (26%)                               
      Lymphoma Malignant                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05162-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:58:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      8 MG/KG      16 MG/KG     32 MG/KG                                  
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            46          42          43          45                                       
     Total Primary Neoplasms                           78          81          68          73                                       
   Total Animals with Benign Neoplasms                 38          39          40          41                                       
     Total Benign Neoplasms                            59          63          53          50                                       
   Total Animals with Malignant Neoplasms              17          16          15          22                                       
     Total Malignant Neoplasms                         19          18          15          23                                       
   Total Animals with Metastatic Neoplasms              2                                   4                                       
     Total Metastatic Neoplasm                          2                                  13                                       
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05162-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:58:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      16 MG/KG     32 MG/KG     64 MG/KG                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                31           31           25           22                                     
    Natural Death                                      5            9            4            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           10           21           22                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Rectum                            (50)         (50)         (50)         (49)                                   
      Carcinoma                                                                               1 (2%)                                
   Intestine Small, Jejunum                           (50)         (46)         (48)         (48)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                                        2 (4%)                    1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Mesentery                                          (7)          (4)          (8)          (3)                                    
      Histiocytic Sarcoma                                                        1 (13%)                                            
   Oral Mucosa                                        (7)          (2)          (2)                                                 
      Squamous Cell Carcinoma                          1 (14%)      1 (50%)                                                         
      Squamous Cell Papilloma                                       1 (50%)                                                         
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
   Salivary Glands                                    (50)         (49)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Schwannoma Malignant                                          1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
      Yolk Sac Carcinoma, Metastatic, Tissue NOS       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05162-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:58:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      16 MG/KG     32 MG/KG     64 MG/KG                                  
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    2 (4%)                                             
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          8 (16%)      7 (14%)      4 (8%)      12 (24%)                               
      Bilateral, Pheochromocytoma Benign               1 (2%)                    3 (6%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
      Carcinoma                                        2 (4%)       1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (46)         (49)         (48)         (47)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (50)         (50)         (50)         (49)                                   
      Astrocytoma Malignant, Metastatic, Brain         1 (2%)                                                                       
      Pars Distalis, Adenoma                          32 (64%)     39 (78%)     37 (74%)     27 (55%)                               
      Pars Distalis, Adenoma, Multiple                                           2 (4%)       5 (10%)                               
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                                                  1 (2%)                                             
      Bilateral, C-Cell, Adenoma                                                              1 (2%)                                
      C-Cell, Adenoma                                  6 (12%)      2 (4%)       5 (10%)      6 (12%)                               
      C-Cell, Carcinoma                                             1 (2%)                                                          
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   Tissue NOS                                         (1)                                                                           
      Yolk Sac Carcinoma                               1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Preputial Gland                                    (50)         (50)         (49)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)       4 (8%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           12 (24%)      9 (18%)     13 (26%)     10 (20%)                               
      Interstitial Cell, Adenoma                      20 (40%)     10 (20%)     15 (30%)     16 (32%)                               
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05162-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:58:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      16 MG/KG     32 MG/KG     64 MG/KG                                  
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node                                         (4)          (4)          (5)          (2)                                    
      Deep Cervical, Bronchial, Mediastinal,                                                                                        
          Leukemia Mononuclear                                      1 (25%)                                                         
      Deep Cervical, Mediastinal, Carcinoma,                                                                                        
          Metastatic, Thyroid Gland                                              1 (20%)                                            
      Mediastinal, Histiocytic Sarcoma                                           1 (20%)                                            
      Thoracic, Schwannoma Malignant                                                          1 (50%)                               
   Lymph Node, Mandibular                             (49)         (48)         (50)         (49)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrosarcoma                                                  1 (2%)                                                          
   Thymus                                             (47)         (48)         (48)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (46)         (48)         (45)         (42)                                   
      Adenoma                                                                                 1 (2%)                                
      Carcinoma                                                                  1 (2%)                                             
      Fibroadenoma                                     1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (50)                                   
      Keratoacanthoma                                  2 (4%)       1 (2%)                                                          
      Schwannoma Malignant                                                       1 (2%)       1 (2%)                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                       1 (2%)       1 (2%)                                             
      Sebaceous Gland, Adenoma                         2 (4%)                                                                       
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Adenoma                                                               1 (2%)                                             
      Skin, Site of Application, Keratoacanthoma                    1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                                  1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Schwannoma Malignant                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                     2 (4%)       1 (2%)                                                          
   Skeletal Muscle                                                 (1)                                                              
      Histiocytic Sarcoma                                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                             Page   9                                                               
NTP Experiment-Test: 05162-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:58:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      16 MG/KG     32 MG/KG     64 MG/KG                                  
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                            1 (2%)                                                                       
   Spinal Cord                                        (2)                       (1)          (1)                                    
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                                            1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Pituitary                                                                                    
          Gland                                                     1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                   1 (2%)       1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
      Yolk Sac Carcinoma, Metastatic, Tissue NOS       1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (49)                                   
      Chondroma                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Harderian Gland                                    (3)                                                                           
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                       1 (33%)                                                                      
   Zymbal's Gland                                                  (3)          (1)          (2)                                    
      Carcinoma                                                     2 (67%)      1 (100%)     1 (50%)                               
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Nephroblastoma                                   1 (2%)                                                                       
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
   Urinary Bladder                                    (48)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Leukemia Mononuclear                            23 (46%)     14 (28%)     13 (26%)     18 (36%)                               
      Lymphoma Malignant                               1 (2%)                                                                       
      Mesothelioma Malignant                           2 (4%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05162-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           DIETHANOLAMINE                                      Date: 04/08/96  
Route: SKIN APPLICATION                                                                                           Time: 09:58:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      16 MG/KG     32 MG/KG     64 MG/KG                                  
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            50          49          49          47                                       
     Total Primary Neoplasms                          126         107         107         112                                       
   Total Animals with Benign Neoplasms                 47          46          48          45                                       
     Total Benign Neoplasms                            90          78          86          88                                       
   Total Animals with Malignant Neoplasms              32          23          19          22                                       
     Total Malignant Neoplasms                         36          29          21          24                                       
   Total Animals with Metastatic Neoplasms              5           3           1                                                   
     Total Metastatic Neoplasm                          7           3           1                                                   
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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