TDMS Study 05165-02 Pathology Tables
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
Facility: Battelle Columbus Laboratory
Chemical CAS #: 96-69-5
Lock Date: 01/10/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 5| 7| 4| 4| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 8| 9| 3| 5| 5| 3| 3|
| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 3| 3| 5| 3| 7| 3| 3| 3| 6| 3| 3| 7| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Necrosis, Focal | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + M + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic Active | 2 |
Necrosis | 1 |
Hepatocyte, Fatty Change | 3 1 |
Hepatocyte, Hypertrophy | 2 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +|
Necrosis | 2 |
Submucosa, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X|
Hematopoietic Cell Proliferation | |
Hypertrophy | 2 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + M + + + M + + + M M +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 5| 7| 4| 4| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 8| 9| 3| 5| 5| 3| 3|
| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 3| 3| 5| 3| 7| 3| 3| 3| 6| 3| 3| 7| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 4 |
Thrombosis | |
Follicle, Cyst | X X X X X X X X X X X X X X|
Periovarian Tissue, Cyst | |
Periovarian Tissue, Inflammation, | |
Granulomatous | |
Rete Ovarii, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 4 2 3 3 3 2 3 2 4 2 3 3 3 2 3 2 3 3 2 3 2 2 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 3 3 2 3 1 2 2 3|
__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Lymphocyte, Necrosis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + M + + + M + + M + + +|
Cyst | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Histiocytic, Macrophage | 2 1 1 2 3 1 2 2 1 1 3 2 2 2 2 2 2 2 2|
Infiltration Cellular, Histiocyte | 1 |
Lymphocyte, Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 4 4 4 |
Lymphocyte, Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M M + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 5| 7| 4| 4| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 8| 9| 3| 5| 5| 3| 3|
| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 3| 3| 5| 3| 7| 3| 3| 3| 6| 3| 3| 7| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | 3 4 2 3|
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + |
Sciatic, Axon, Degeneration | 2 2 |
__________________________________________________________________________|
Spinal Cord | + + |
Axon, Degeneration | 3 |
Lumbar, Axon, Nerve, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Mediastinum, Inflammation, Chronic | |
Active | 3 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Nephropathy, Chronic | 1 2 1 2 2 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 7| 4| 3| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 5| 6| 3| 3| 3| 3| 3| 5| 6| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3| 2| 5| 3| 3| 3| 2|
| 7| 4| 3| 3| 3| 3| 3| 7| 9| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 4| 7| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X |
Eosinophilic Focus | X X X X X X X |
Hematopoietic Cell Proliferation | 4 |
Inflammation, Chronic Active | |
Necrosis | |
Hepatocyte, Fatty Change | 2 2 2 1 |
Hepatocyte, Hypertrophy | 1 |
Serosa, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Submucosa, Inflammation, Chronic | |
Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hematopoietic Cell Proliferation | 2 |
Hypertrophy | 3|
Capsule, Accessory Adrenal Cortical | |
Nodule | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 7| 4| 3| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 5| 6| 3| 3| 3| 3| 3| 5| 6| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3| 2| 5| 3| 3| 3| 2|
| 7| 4| 3| 3| 3| 3| 3| 7| 9| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 4| 7| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Thrombosis | X |
Follicle, Cyst | X X X X X X X X X X |
Periovarian Tissue, Cyst | X |
Periovarian Tissue, Inflammation, | |
Granulomatous | 4 |
Rete Ovarii, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 3 3 4 3 2 2 2 3 4 3 2 3 3 3 2 3 3 3 3 3 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 2 3 2 3 2 2 1 1 3 |
__________________________________________________________________________|
Lymph Node | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphocyte, Necrosis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + M + + + + + + + + + + + + M +|
Cyst | X |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Histiocytic, Macrophage | 3 2 2 1 1 2 1 1 1 3 1 2 2 2 2 2 3|
Infiltration Cellular, Histiocyte | 1 1 2 |
Lymphocyte, Necrosis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2|
Hematopoietic Cell Proliferation | 2 3|
Lymphocyte, Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + M + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 7| 4| 3| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 5| 6| 3| 3| 3| 3| 3| 5| 6| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3| 2| 5| 3| 3| 3| 2|
| 7| 4| 3| 3| 3| 3| 3| 7| 9| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 4| 7| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | 3 4|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | |
Sciatic, Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | |
Axon, Degeneration | |
Lumbar, Axon, Nerve, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Mediastinum, Inflammation, Chronic | |
Active | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Nephropathy, Chronic | 1 1 2 1 2 2 1 1 3 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 3| 3| 5| 3| 3| 3| 1| 3| | |
| 3| 9| 3| 3| 7| 3| 3| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.5|
Basophilic Focus | X | 2 |
Eosinophilic Focus | X | 10 |
Hematopoietic Cell Proliferation | 2 | 2 3.0|
Inflammation, Chronic Active | | 1 2.0|
Necrosis | | 1 1.0|
Hepatocyte, Fatty Change | 3 | 7 2.0|
Hepatocyte, Hypertrophy | | 2 1.5|
Serosa, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Fat, Inflammation, Chronic Active | 2 | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Necrosis | | 1 2.0|
Submucosa, Inflammation, Chronic | | |
Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Degeneration, Chronic | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Cyst | X | 2 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hypertrophy | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 3| 3| 5| 3| 3| 3| 1| 3| | |
| 3| 9| 3| 3| 7| 3| 3| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + M | 58 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + M | 52 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + | 57 |
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia | 2 | 9 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicle, Cyst | | 2 |
Follicular Cell, Hyperplasia | 2 | 4 2.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Ovary | + + + I + + + + + + | 59 |
Inflammation, Granulomatous | | 1 4.0|
Thrombosis | | 1 |
Follicle, Cyst | X X | 26 |
Periovarian Tissue, Cyst | | 1 |
Periovarian Tissue, Inflammation, | | |
Granulomatous | | 1 4.0|
Rete Ovarii, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 3 2 2 3 4 3 4 3 3 3 | 57 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | 3 | 21 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + + | 9 |
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Lymphocyte, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 3| 3| 5| 3| 3| 3| 1| 3| | |
| 3| 9| 3| 3| 7| 3| 3| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | | 1 |
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Histiocytic, Macrophage | 3 2 2 1 | 40 1.9|
Infiltration Cellular, Histiocyte | 1 | 5 1.2|
Lymphocyte, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 | 8 3.1|
Lymphocyte, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 55 |
Depletion Lymphoid | | 6 3.2|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 1 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
Sciatic, Axon, Degeneration | | 2 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
Axon, Degeneration | | 1 3.0|
Lumbar, Axon, Nerve, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage, Focal | | 1 2.0|
Mediastinum, Inflammation, Chronic | | |
Active | | 1 3.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 3| 3| 5| 3| 3| 3| 1| 3| | |
| 3| 9| 3| 3| 7| 3| 3| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 4.0|
Nephropathy, Chronic | 1 1 | 22 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 7| 6| 7| 6| 1|
DAY ON TEST | 3| 3| 3| 6| 1| 3| 3| 5| 3| 5| 3| 5| 3| 3| 5| 3| 5| 3| 5| 3| 3| 0| 3| 9| 6|
| 1| 1| 1| 6| 8| 1| 1| 7| 1| 7| 1| 0| 1| 1| 7| 1| 7| 1| 7| 1| 1| 3| 1| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X |
Hematopoietic Cell Proliferation | 2 1 2 |
Necrosis | 3 |
Bile Duct, Dilatation | 3 |
Hepatocyte, Fatty Change | 1 2 |
Periportal, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + |
Degeneration, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Hyperplasia | |
Hypertrophy | 1 |
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + |
Pars Distalis, Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 7| 6| 7| 6| 1|
DAY ON TEST | 3| 3| 3| 6| 1| 3| 3| 5| 3| 5| 3| 5| 3| 3| 5| 3| 5| 3| 5| 3| 3| 0| 3| 9| 6|
| 1| 1| 1| 6| 8| 1| 1| 7| 1| 7| 1| 0| 1| 1| 7| 1| 7| 1| 7| 1| 1| 3| 1| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 2 2 2 2 3 2 2 |
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 |
Ultimobranchial Cyst | X |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + M |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 3 |
Bilateral, Inflammation, | |
Granulomatous | 4 |
Bilateral, Follicle, Cyst | X |
Follicle, Cyst | X X X X X X X X |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 2 3 4 2 3 2 3 3 2 2 4 3 3 2 3 2 4 2 3 3 2 2 |
Endometrium, Vein, Thrombosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + |
Myelofibrosis | 4 2 1 3 2 |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Inflammation, Chronic | |
Active | |
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 4 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + M + + + + + + + + + |
Hyperplasia, Histiocytic, Macrophage | 1 2 2 2 2 1 1 1 1 2 2 2 2 |
Infiltration Cellular, Histiocyte | 2 1 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 7| 6| 7| 6| 1|
DAY ON TEST | 3| 3| 3| 6| 1| 3| 3| 5| 3| 5| 3| 5| 3| 3| 5| 3| 5| 3| 5| 3| 3| 0| 3| 9| 6|
| 1| 1| 1| 6| 8| 1| 1| 7| 1| 7| 1| 0| 1| 1| 7| 1| 7| 1| 7| 1| 1| 3| 1| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 3 4 4 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + M |
Concretion | |
Depletion Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, Hemorrhage | |
Subcutaneous Tissue, Inflammation, | |
Acute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + |
Compression | X |
__________________________________________________________________________|
Peripheral Nerve | |
Sciatic, Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 3 |
Alveolar Epithelium, Hyperplasia | 2 1 |
Mediastinum, Inflammation, Chronic | |
Active | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 7| 6| 7| 6| 1|
DAY ON TEST | 3| 3| 3| 6| 1| 3| 3| 5| 3| 5| 3| 5| 3| 3| 5| 3| 5| 3| 5| 3| 3| 0| 3| 9| 6|
| 1| 1| 1| 6| 8| 1| 1| 7| 1| 7| 1| 0| 1| 1| 7| 1| 7| 1| 7| 1| 1| 3| 1| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + |
Nephropathy, Chronic | 2 1 2 1 1 2 2 1 1 1 1 3 |
Cortex, Infarct | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 6| 3| 3| 9| 3| 2| 3| 0| 2| 3| 3| 7| 3| 0| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|
| 7| 5| 1| 1| 9| 2| 1| 2| 5| 3| 2| 2| 4| 2| 5| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | |
Necrosis | |
Bile Duct, Dilatation | |
Hepatocyte, Fatty Change | 2 3 1 |
Periportal, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | 2 2 |
Hypertrophy | 3 3 1 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + M + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 6| 3| 3| 9| 3| 2| 3| 0| 2| 3| 3| 7| 3| 0| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|
| 7| 5| 1| 1| 9| 2| 1| 2| 5| 3| 2| 2| 4| 2| 5| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 2 2 2 2 |
Pars Intermedia, Cyst | X |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ultimobranchial Cyst | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + M + + M + + + + + + + + +|
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Bilateral, Inflammation, | |
Granulomatous | 4 |
Bilateral, Follicle, Cyst | X X |
Follicle, Cyst | X X X X X X X X|
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 4 3 3 2 3 2 2 3 2 3 2 3 3 2 3 3 2 2 3 2 3 3 3|
Endometrium, Vein, Thrombosis | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 1 2 2 1 1 2 2 2|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Inflammation, Chronic | |
Active | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + M + + + + + + + + M +|
Hyperplasia, Histiocytic, Macrophage | 2 2 2 2 2 2 1 2 3 1 2 1 2 2 1|
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 6| 3| 3| 9| 3| 2| 3| 0| 2| 3| 3| 7| 3| 0| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|
| 7| 5| 1| 1| 9| 2| 1| 2| 5| 3| 2| 2| 4| 2| 5| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 3 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + M + + + M + M + + + + + + + + + +|
Concretion | 2 |
Depletion Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemorrhage | 3 |
Subcutaneous Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
__________________________________________________________________________|
Peripheral Nerve | + |
Sciatic, Axon, Degeneration | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | |
Mediastinum, Inflammation, Chronic | |
Active | 3 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 2 1|
Perivascular, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 6| 3| 3| 9| 3| 2| 3| 0| 2| 3| 3| 7| 3| 0| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|
| 7| 5| 1| 1| 9| 2| 1| 2| 5| 3| 2| 2| 4| 2| 5| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 1 1 2 1 1 1 1 2 3 1|
Cortex, Infarct | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 5| 3| 3| | |
| 2| 7| 2| 2| 2| 2| 2| 7| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Basophilic Focus | X | 4 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X | 8 |
Hematopoietic Cell Proliferation | 1 | 4 1.5|
Necrosis | | 1 3.0|
Bile Duct, Dilatation | | 1 3.0|
Hepatocyte, Fatty Change | 3 | 6 2.0|
Periportal, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Fat, Inflammation, Chronic Active | | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | | 1 3.0|
Acinus, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Degeneration, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Cyst | | 1 |
Hyperplasia | | 2 2.0|
Hypertrophy | 2 | 6 2.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | X | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 5| 3| 3| | |
| 2| 7| 2| 2| 2| 2| 2| 7| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | | 2 3.0|
Pars Distalis, Hyperplasia | 2 1 1 | 14 1.9|
Pars Intermedia, Cyst | | 1 |
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | | 1 1.0|
Ultimobranchial Cyst | | 1 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + | 45 |
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Angiectasis | | 1 3.0|
Bilateral, Inflammation, | | |
Granulomatous | | 2 4.0|
Bilateral, Follicle, Cyst | | 3 |
Follicle, Cyst | X X X X X X | 22 |
Periovarian Tissue, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 3 2 2 2 2 3 3 3 2 2 | 57 2.6|
Endometrium, Vein, Thrombosis | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Myelofibrosis | 2 2 1 2 | 18 1.9|
Femoral, Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 7 |
Inguinal, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 5| 3| 3| | |
| 2| 7| 2| 2| 2| 2| 2| 7| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Congestion | | 2 2.5|
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Lymphoid | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M M M + + + | 51 |
Hyperplasia, Histiocytic, Macrophage | 1 3 1 2 1 | 33 1.7|
Infiltration Cellular, Histiocyte | 1 | 3 1.3|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | 3 3 | 12 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + | 52 |
Concretion | | 1 2.0|
Depletion Lymphoid | | 2 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Hyperplasia, Cystic | | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Subcutaneous Tissue, Hemorrhage | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Compression | | 3 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Sciatic, Axon, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Inflammation, Acute | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 5| 3| 3| | |
| 2| 7| 2| 2| 2| 2| 2| 7| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mediastinum, Inflammation, Chronic | | |
Active | | 1 3.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 2 | 5 1.8|
Perivascular, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Nephropathy, Chronic | 1 1 3 | 27 1.4|
Cortex, Infarct | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6| 7| 7| 4| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 4|
DAY ON TEST | 1| 2| 3| 3| 3| 9| 3| 3| 5| 6| 8| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 9| 3| 3| 5|
| 7| 6| 0| 0| 0| 9| 0| 0| 7| 1| 5| 0| 0| 7| 0| 0| 7| 4| 7| 2| 0| 7| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | |
Vacuolization Cytoplasmic | |
Bile Duct, Cyst | |
Hepatocyte, Fatty Change | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 1|
Duct, Cyst | |
__________________________________________________________________________|
Pharynx | + |
Submucosa, Palate, Infiltration | |
Cellular, Mast Cell | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Multifocal | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy | 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6| 7| 7| 4| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 4|
DAY ON TEST | 1| 2| 3| 3| 3| 9| 3| 3| 5| 6| 8| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 9| 3| 3| 5|
| 7| 6| 0| 0| 0| 9| 0| 0| 7| 1| 5| 0| 0| 7| 0| 0| 7| 4| 7| 2| 0| 7| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Bilateral, Periovarian Tissue, Cyst | X |
Bilateral, Follicle, Cyst | X X |
Follicle, Cyst | X X X X X X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 3 2 3 3 3 3 3 2 3 3 2 3 2 2 3 3 3 1 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 1 2 2 2 1 2 |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | M M + + + M + + + + + + + + + + + M + + + + + + +|
Hyperplasia, Histiocytic, Macrophage | 2 3 1 1 2 2 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | 2 1 1 2|
Lymphatic, Cyst | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 3 4 3 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M M + + + + + + M + + + + + + +|
Depletion Lymphoid | 3 2 3 2 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Ulcer | |
Tail, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6| 7| 7| 4| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 4|
DAY ON TEST | 1| 2| 3| 3| 3| 9| 3| 3| 5| 6| 8| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 9| 3| 3| 5|
| 7| 6| 0| 0| 0| 9| 0| 0| 7| 1| 5| 0| 0| 7| 0| 0| 7| 4| 7| 2| 0| 7| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Neuron, Degeneration | |
__________________________________________________________________________|
Peripheral Nerve | |
Sciatic, Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | |
Lumbar, Axon, Nerve, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Macrophage | 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Nephropathy, Chronic | 1 1 2 2 1 |
Cortex, Cyst | |
Cortex, Infarct | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 4| 0| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| 5| 6| 3|
| 7| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 7| 0| 0| 0| 5| 0| 0| 8| 1| 1| 1| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X |
Hematopoietic Cell Proliferation | 2 |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Cyst | X |
Hepatocyte, Fatty Change | |
__________________________________________________________________________|
Mesentery | +|
Fat, Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Duct, Cyst | X |
__________________________________________________________________________|
Pharynx | |
Submucosa, Palate, Infiltration | |
Cellular, Mast Cell | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Multifocal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 2 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 4| 0| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| 5| 6| 3|
| 7| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 7| 0| 0| 0| 5| 0| 0| 8| 1| 1| 1| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + +|
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +|
Mineralization | 3 |
Bilateral, Periovarian Tissue, Cyst | |
Bilateral, Follicle, Cyst | |
Follicle, Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 3 1 2 3 2 2 2 3 2 3 3 2 2 2 3 3 2 3 3 2 1 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 1 1 2 2 1 1 2 2 1 1|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + M M|
Hyperplasia, Histiocytic, Macrophage | 3 2 2 2 2 1 3 2 2 2 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | 1 1 2 |
Lymphatic, Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + M + + + + + +|
Depletion Lymphoid | 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Ulcer | |
Tail, Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 4| 0| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| 5| 6| 3|
| 7| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 7| 0| 0| 0| 5| 0| 0| 8| 1| 1| 1| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Neuron, Degeneration | 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
Sciatic, Axon, Degeneration | 2 |
__________________________________________________________________________|
Spinal Cord | + |
Lumbar, Axon, Nerve, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Macrophage | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Nephropathy, Chronic | 1 1 1 3 1 1 1 3 |
Cortex, Cyst | X |
Cortex, Infarct | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 0| 5| 3| 7| | |
| 7| 1| 1| 1| 1| 1| 1| 7| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 3 | 1 3.0|
Basophilic Focus | X | 3 |
Clear Cell Focus | X | 3 |
Eosinophilic Focus | X X | 10 |
Hematopoietic Cell Proliferation | | 1 2.0|
Vacuolization Cytoplasmic | | 1 2.0|
Bile Duct, Cyst | X | 2 |
Hepatocyte, Fatty Change | 2 1 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + M + + + | 59 |
Acinus, Atrophy | 1 | 3 1.7|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
Submucosa, Palate, Infiltration | | |
Cellular, Mast Cell | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + M + + + | 57 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
Hypertrophy | | 5 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 0| 5| 3| 7| | |
| 7| 1| 1| 1| 1| 1| 1| 7| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + | 59 |
Pars Distalis, Hyperplasia | 2 3 | 13 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + M | 59 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + | 48 |
Duct, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Mineralization | 3 | 2 3.0|
Bilateral, Periovarian Tissue, Cyst | | 1 |
Bilateral, Follicle, Cyst | | 2 |
Follicle, Cyst | X X X X X X | 23 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 3 2 2 3 3 2 3 3 4 | 52 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | 1 1 1 2 2 | 23 1.5|
__________________________________________________________________________|____________|
Lymph Node | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + | 57 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + M | 51 |
Hyperplasia, Histiocytic, Macrophage | 2 2 2 2 1 | 31 2.0|
Infiltration Cellular, Histiocyte | 2 2 | 9 1.6|
Lymphatic, Cyst | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Depletion Lymphoid | | 2 2.0|
Hematopoietic Cell Proliferation | | 7 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + | 54 |
Depletion Lymphoid | | 8 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 0| 5| 3| 7| | |
| 7| 1| 1| 1| 1| 1| 1| 7| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inguinal, Ulcer | 3 | 1 3.0|
Tail, Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 3 |
Neuron, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Sciatic, Axon, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Lumbar, Axon, Nerve, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar Epithelium, Hyperplasia, | | |
Macrophage | | 1 2.5|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 4.0|
Nephropathy, Chronic | 1 2 2 | 16 1.5|
Cortex, Cyst | | 1 |
Cortex, Infarct | | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 6| 7| 1| 7| 7| 7| 4| 7| 4| 7| 4| 7| 4| 4| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 6| 2| 5| 2| 2| 2| 5| 2| 5| 2| 5| 2| 5| 5| 2| 2| 8| 2| 6| 9| 2| 2| 2| 2| 8|
| 1| 9| 6| 9| 9| 9| 7| 9| 7| 9| 7| 9| 7| 7| 9| 9| 0| 9| 5| 7| 9| 9| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X |
Hepatocyte, Fatty Change | 1 1 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
Hypertrophy | 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 2 3 2 2 2|
Pars Distalis, Hypertrophy | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Follicle, Cyst, Multiple | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 6| 7| 1| 7| 7| 7| 4| 7| 4| 7| 4| 7| 4| 4| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 6| 2| 5| 2| 2| 2| 5| 2| 5| 2| 5| 2| 5| 5| 2| 2| 8| 2| 6| 9| 2| 2| 2| 2| 8|
| 1| 9| 6| 9| 9| 9| 7| 9| 7| 9| 7| 9| 7| 7| 9| 9| 0| 9| 5| 7| 9| 9| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + M + + + + M|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Mineralization | |
Bilateral, Inflammation, | |
Granulomatous | 4 |
Bilateral, Follicle, Cyst | X X |
Follicle, Cyst | X X X X X X X X X X X|
Periovarian Tissue, Cyst | X |
Rete Ovarii, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 3 3 3 2 4 2 3 3 2 3 3 3 3 3 2 3 3 3 1 4 2 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 2 3 3 3 1 2 3 2 3 2 2 1|
Femoral, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + +|
Mediastinal, Inflammation, Acute | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + M + + + + + M + + M + + + + + + + +|
Hyperplasia, Histiocytic, Macrophage | 3 3 2 2 2 3 2 2 3 3 3 3 2 3 3 2 2|
Infiltration Cellular, Histiocyte | 2 3 2 2 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3|
Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
Depletion Lymphoid | 3 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 6| 7| 1| 7| 7| 7| 4| 7| 4| 7| 4| 7| 4| 4| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 6| 2| 5| 2| 2| 2| 5| 2| 5| 2| 5| 2| 5| 5| 2| 2| 8| 2| 6| 9| 2| 2| 2| 2| 8|
| 1| 9| 6| 9| 9| 9| 7| 9| 7| 9| 7| 9| 7| 7| 9| 9| 0| 9| 5| 7| 9| 9| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
Sciatic, Axon, Degeneration | 2 |
__________________________________________________________________________|
Spinal Cord | + |
Axon, Degeneration | |
Lumbar, Axon, Nerve, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | 2 |
Nephropathy, Chronic | 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 5| 5| 5| 2| 4| 2| 5| 2| 2| 2| 0| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 0| 4|
| 9| 7| 7| 7| 9| 6| 9| 1| 9| 9| 9| 4| 1| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X X X X |
Hepatocyte, Fatty Change | 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 |
Hypertrophy | 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 3 2 2 |
Pars Distalis, Hypertrophy | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Follicle, Cyst, Multiple | X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 5| 5| 5| 2| 4| 2| 5| 2| 2| 2| 0| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 0| 4|
| 9| 7| 7| 7| 9| 6| 9| 1| 9| 9| 9| 4| 1| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + + M + M|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Mineralization | 2 |
Bilateral, Inflammation, | |
Granulomatous | |
Bilateral, Follicle, Cyst | X |
Follicle, Cyst | X X X X X X X X |
Periovarian Tissue, Cyst | X X X X X X |
Rete Ovarii, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 3 4 3 3 3 3 4 3 3 4 3 4 2 3 2 3 2 3 3 3 2 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 2 2 3 2 3 4 2 2 1 2 3 1 1 |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + M + + + + + + + + + M +|
Hyperplasia, Histiocytic, Macrophage | 2 2 2 3 2 2 2 4 3 3 2 3 2 2 1 3 3 2 |
Infiltration Cellular, Histiocyte | 2 2 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 5| 5| 5| 2| 4| 2| 5| 2| 2| 2| 0| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 0| 4|
| 9| 7| 7| 7| 9| 6| 9| 1| 9| 9| 9| 4| 1| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + |
Sciatic, Axon, Degeneration | 2 2 2 |
__________________________________________________________________________|
Spinal Cord | + + + |
Axon, Degeneration | 3 4 |
Lumbar, Axon, Nerve, Degeneration | 3 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 2 1 2 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | |
Nephropathy, Chronic | 1 1 2 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 1| 7| 7| 7| 4| 6| 6| | |
DAY ON TEST | 3| 3| 5| 1| 3| 3| 3| 5| 9| 0| | |
| 0| 0| 7| 3| 0| 0| 0| 7| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Eosinophilic Focus | X X | 7 |
Hepatocyte, Fatty Change | 2 | 6 1.5|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Necrosis | | 1 2.0|
Mucosa, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Degeneration, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Cyst | X | 1 |
Hyperplasia | | 1 2.0|
Hypertrophy | 3 | 3 2.3|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Cyst | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 1| 7| 7| 7| 4| 6| 6| | |
DAY ON TEST | 3| 3| 5| 1| 3| 3| 3| 5| 9| 0| | |
| 0| 0| 7| 3| 0| 0| 0| 7| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia | 3 | 11 2.4|
Pars Distalis, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Cyst | | 1 |
Follicle, Cyst, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Inflammation, Granulomatous | 4 | 1 4.0|
Mineralization | | 1 2.0|
Bilateral, Inflammation, | | |
Granulomatous | | 1 4.0|
Bilateral, Follicle, Cyst | X | 4 |
Follicle, Cyst | X X | 21 |
Periovarian Tissue, Cyst | X | 8 |
Rete Ovarii, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 3 3 3 3 3 3 4 3 3 | 57 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | 2 2 1 2 1 3 2 | 34 2.1|
Femoral, Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 7 |
Mediastinal, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | 1 1 | 6 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + | 52 |
Hyperplasia, Histiocytic, Macrophage | 3 3 2 3 2 2 2 | 42 2.5|
Infiltration Cellular, Histiocyte | 2 2 | 9 2.1|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | 2 | 4 2.5|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 1| 7| 7| 7| 4| 6| 6| | |
DAY ON TEST | 3| 3| 5| 1| 3| 3| 3| 5| 9| 0| | |
| 0| 0| 7| 3| 0| 0| 0| 7| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 58 |
Depletion Lymphoid | | 4 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Hyperplasia, Cystic | | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + M + | 59 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 4 |
Sciatic, Axon, Degeneration | | 4 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 4 |
Axon, Degeneration | | 2 3.5|
Lumbar, Axon, Nerve, Degeneration | | 4 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 4.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 7 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Metaplasia, Focal, Osseous | | 1 2.0|
Nephropathy, Chronic | 1 1 1 1 2 | 18 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7|
DAY ON TEST | 8| 3| 5| 3| 3| 3| 3| 9| 3| 5| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3|
| 3| 2| 6| 2| 2| 2| 2| 0| 2| 6| 2| 2| 6| 2| 3| 3| 3| 3| 3| 6| 1| 3| 3| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 4 |
Peyer's Patch, Ulcer, Chronic Active | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X X X X |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | |
Infarct | 4 |
Necrosis | |
Vacuolization Cytoplasmic | 4 3 3 |
Hepatocyte, Fatty Change | 1 1 2 1 1 2 3 1 |
Vein, Dilatation | 3 |
__________________________________________________________________________|
Mesentery | |
Fat, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Developmental Malformation| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | 2 3 2 2 2 1 2 2 2 1 2|
Capsule, Accessory Adrenal Cortical | |
Nodule | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7|
DAY ON TEST | 8| 3| 5| 3| 3| 3| 3| 9| 3| 5| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3|
| 3| 2| 6| 2| 2| 2| 2| 0| 2| 6| 2| 2| 6| 2| 3| 3| 3| 3| 3| 6| 1| 3| 3| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Duct, Dilatation | 2 2 3 3 3 3 2 3 3 3 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | X |
Seminiferous Tubule, Atrophy | 3 3 |
Tunic, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | |
Hyperplasia, Histiocytic, Macrophage | 1 1 1 1 2 1 1 1 1 1 2 1 2 2 2 2 1 2 1|
Infiltration Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | 2 |
Cyst | X |
Depletion Lymphoid | 2 2 4 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7|
DAY ON TEST | 8| 3| 5| 3| 3| 3| 3| 9| 3| 5| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3|
| 3| 2| 6| 2| 2| 2| 2| 0| 2| 6| 2| 2| 6| 2| 3| 3| 3| 3| 3| 6| 1| 3| 3| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diaphragm, Degeneration, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 3 2 |
Alveolus, Hyperplasia, Macrophage | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | +|
Cornea, Hyperplasia, Squamous | 3|
Cornea, Inflammation, Chronic Active | 3|
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 3 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 5| 6|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 1| 5| 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 5| 0| 5|
| 3| 3| 3| 6| 3| 3| 3| 3| 3| 0| 2| 5| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
Peyer's Patch, Ulcer, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 2 |
Infarct | |
Necrosis | 3 2 |
Vacuolization Cytoplasmic | 2 |
Hepatocyte, Fatty Change | 2 3 3 2 3 2 |
Vein, Dilatation | |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Developmental Malformation| X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Hypertrophy | 1 1 2 2 1 2 1 2 1 2 1 1 2 1|
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 5| 6|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 1| 5| 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 5| 0| 5|
| 3| 3| 3| 6| 3| 3| 3| 3| 3| 0| 2| 5| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + I M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 |
Duct, Dilatation | 3 3 3 3 3 3 3 2 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
Seminiferous Tubule, Atrophy | |
Tunic, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 4 |
Infiltration Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +|
Congestion | 4|
Depletion Lymphoid | 4 |
Hyperplasia, Histiocytic, Macrophage | 1 2 2 1 1 1 2 1 1 2 2 1 2 2 1 2 1 2 2 2 2 1|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | 3 2 3 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M M + + + + + + + +|
Angiectasis | |
Cyst | |
Depletion Lymphoid | 3 4 3 2 2 4 3 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M + M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 5| 6|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 1| 5| 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 5| 0| 5|
| 3| 3| 3| 6| 3| 3| 3| 3| 3| 0| 2| 5| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diaphragm, Degeneration, Chronic | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Hyperplasia, Macrophage | 3 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cornea, Hyperplasia, Squamous | |
Cornea, Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 3 2 2 2 2 2 2 4 2 2 2 2 2 2 2 3 2 2 2 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 5| 3| | |
| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 4.0|
Peyer's Patch, Ulcer, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Clear Cell Focus | | 6 |
Eosinophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infarct | | 1 4.0|
Necrosis | | 2 2.5|
Vacuolization Cytoplasmic | 2 2 | 6 2.7|
Hepatocyte, Fatty Change | 2 1 1 1 1 | 21 1.9|
Vein, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Submucosa, Developmental Malformation| X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia | | 1 1.0|
Hypertrophy | 1 2 2 1 1 | 30 1.6|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 5| 3| | |
| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 59 |
Cyst | X | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + I + | 55 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 55 |
Inflammation, Chronic Active | 4 | 3 3.0|
Duct, Dilatation | 2 3 3 3 | 27 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Spermatocele | | 1 |
Seminiferous Tubule, Atrophy | | 2 3.0|
Tunic, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 59 |
Depletion Lymphoid | | 1 4.0|
Infiltration Cellular, Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + | 58 |
Congestion | | 1 4.0|
Depletion Lymphoid | 2 | 2 3.0|
Hyperplasia, Histiocytic, Macrophage | 1 2 1 1 1 2 1 | 48 1.4|
Infiltration Cellular, Histiocyte | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Depletion Lymphoid | | 1 3.0|
Hematopoietic Cell Proliferation | | 5 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + I + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 5| 3| | |
| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | | 1 2.0|
Cyst | | 1 |
Depletion Lymphoid | | 12 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Diaphragm, Degeneration, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar Epithelium, Hyperplasia | | 2 2.5|
Alveolus, Hyperplasia, Macrophage | | 1 3.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Hyperplasia, Squamous | | 1 3.0|
Cornea, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy, Chronic | 2 2 2 3 2 2 1 2 2 | 56 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 8| 3| 8| 3| 3| 3| 3| 3| 5| 3| 2| 5| 3| 3| 3| 5| 3| 5| 3|
| 6| 1| 1| 1| 1| 1| 0| 1| 9| 1| 1| 1| 1| 1| 6| 1| 9| 7| 1| 1| 1| 6| 2| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Inflammation, Acute | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Clear Cell Focus, Multiple | X |
Eosinophilic Focus | X |
Necrosis | |
Thrombosis | X |
Vacuolization Cytoplasmic | |
Hepatocyte, Fatty Change | 2 2 3 1 3 1 1 1 2 1|
Serosa, Fibrosis | |
__________________________________________________________________________|
Mesentery | |
Fat, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 1 |
Acinus, Karyomegaly | 2 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aortic Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Ectopic Tissue | |
Hypertrophy | 2 1 1 2 2 2 1 2 3 1 2 2 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 8| 3| 8| 3| 3| 3| 3| 3| 5| 3| 2| 5| 3| 3| 3| 5| 3| 5| 3|
| 6| 1| 1| 1| 1| 1| 0| 1| 9| 1| 1| 1| 1| 1| 6| 1| 9| 7| 1| 1| 1| 6| 2| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + M + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Duct, Dilatation | 3 3 3 3 3 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + M + + + + + + + M + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Histiocytic, Macrophage | 2 1 2 2 2 1 2 2 2 2 2 1 2 1 2 2|
Infiltration Cellular, Histiocyte | 1 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + M + + + + + + + +|
Depletion Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 8| 3| 8| 3| 3| 3| 3| 3| 5| 3| 2| 5| 3| 3| 3| 5| 3| 5| 3|
| 6| 1| 1| 1| 1| 1| 0| 1| 9| 1| 1| 1| 1| 1| 6| 1| 9| 7| 1| 1| 1| 6| 2| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
Sciatic, Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | |
Axon, Degeneration | |
Lumbar, Axon, Nerve, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 2 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Hyperplasia, Squamous | 4 |
Cornea, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Infiltration Cellular, Mast Cell | |
Nephropathy, Chronic | 1 1 2 2 2 2 2 1 3 3 2 2 2 1 2 2 3 2 2 2 2 2 2 2|
Cortex, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 4| 6| 7| 4| 6| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 5| 6| 3| 5| 3| 5| 3| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3|
| 2| 6| 2| 2| 2| 2| 6| 1| 2| 6| 8| 6| 2| 2| 9| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Inflammation, Acute | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X|
Clear Cell Focus, Multiple | X X |
Eosinophilic Focus | X X |
Necrosis | 4 |
Thrombosis | |
Vacuolization Cytoplasmic | 3 1 |
Hepatocyte, Fatty Change | 3 2 3 3 1 3 2 |
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 |
Acinus, Karyomegaly | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aortic Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Ectopic Tissue | X |
Hypertrophy | 2 1 1 2 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 4| 6| 7| 4| 6| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 5| 6| 3| 5| 3| 5| 3| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3|
| 2| 6| 2| 2| 2| 2| 6| 1| 2| 6| 8| 6| 2| 2| 9| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Duct, Dilatation | 3 3 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
Seminiferous Tubule, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Histiocytic, Macrophage | 2 2 2 2 2 2 2 1 1 2 1 2 2 1 2|
Infiltration Cellular, Histiocyte | 1 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Depletion Lymphoid | 2 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 4| 6| 7| 4| 6| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 5| 6| 3| 5| 3| 5| 3| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3|
| 2| 6| 2| 2| 2| 2| 6| 1| 2| 6| 8| 6| 2| 2| 9| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
Sciatic, Axon, Degeneration | 1 |
__________________________________________________________________________|
Spinal Cord | + |
Axon, Degeneration | 3 |
Lumbar, Axon, Nerve, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Hyperplasia, Squamous | 3 |
Cornea, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Harderian Gland | + + +|
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infiltration Cellular, Mast Cell | 2|
Nephropathy, Chronic | 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 1 2 1|
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 7| 5| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 3| 7| 3| 0| 3| 3| | |
| 6| 2| 2| 2| 2| 3| 2| 7| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Mucosa, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Peyer's Patch, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Clear Cell Focus | | 2 |
Clear Cell Focus, Multiple | | 3 |
Eosinophilic Focus | | 3 |
Necrosis | | 1 4.0|
Thrombosis | | 1 |
Vacuolization Cytoplasmic | | 2 2.0|
Hepatocyte, Fatty Change | | 17 2.0|
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | | 3 3.0|
Acinus, Karyomegaly | | 1 2.0|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Aortic Valve, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 |
Ectopic Tissue | | 1 |
Hypertrophy | 1 2 1 2 1 | 33 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 7| 5| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 3| 7| 3| 0| 3| 3| | |
| 6| 2| 2| 2| 2| 3| 2| 7| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 58 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + I + + | 56 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicle, Cyst | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 49 |
Inflammation, Chronic Active | | 2 2.5|
Duct, Dilatation | 2 3 3 | 14 2.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Mineralization | | 1 3.0|
Seminiferous Tubule, Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + | 57 |
Infiltration Cellular, Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + | 55 |
Congestion | | 1 4.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Histiocytic, Macrophage | 2 2 2 2 2 2 | 37 1.8|
Infiltration Cellular, Histiocyte | | 6 1.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 7| 5| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 3| 7| 3| 0| 3| 3| | |
| 6| 2| 2| 2| 2| 3| 2| 7| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | 4 | 6 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Sciatic, Axon, Degeneration | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Axon, Degeneration | | 1 3.0|
Lumbar, Axon, Nerve, Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar Epithelium, Hyperplasia | | 4 2.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 | 5 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Hyperplasia, Squamous | | 2 3.5|
Cornea, Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Harderian Gland | | 4 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hydronephrosis | | 1 2.0|
Infiltration Cellular, Mast Cell | | 1 2.0|
Nephropathy, Chronic | 2 1 2 1 2 2 3 2 2 | 55 1.9|
Cortex, Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 7| 5| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 3| 7| 3| 0| 3| 3| | |
| 6| 2| 2| 2| 2| 3| 2| 7| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 3| 5|
| 0| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 6| 0| 0| 6| 0| 6| 0| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | X |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
Bile Duct, Cyst | X |
Hepatocyte, Fatty Change | 1 1 3 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Multifocal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy | 2 2 2 2 1 1 1 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 3| 5|
| 0| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 6| 0| 0| 6| 0| 6| 0| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 4 2 |
Duct, Dilatation | 3 3 2 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M M + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic, Macrophage | 2 1 3 2 3 2 2 2 2 2 3 2 2 2 2 3 2 2 1 |
Infiltration Cellular, Histiocyte | 2 2 2 1 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Inflammation, Chronic | |
Active, Necrotizing | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 3| 5|
| 0| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 6| 0| 0| 6| 0| 6| 0| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Macrophage | 3 |
Alveolar Epithelium, Hyperplasia | 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 2 2 2 3 4 2 2 2 1 2 2 3 2 1 2 2 1 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5|
| 6| 0| 0| 0| 0| 0| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Necrosis | |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Cyst | |
Hepatocyte, Fatty Change | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Multifocal | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Hypertrophy | 2 2 1 2 3 2 1 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5|
| 6| 0| 0| 0| 0| 0| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 3 |
Duct, Dilatation | 4 2 2 2 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M M + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic, Macrophage | 2 2 3 2 2 2 2 2 3 1 2 3 2 2 2 1 1 3 |
Infiltration Cellular, Histiocyte | 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 2 |
__________________________________________________________________________|
Thymus | + + M M + + + M + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Inflammation, Chronic | |
Active, Necrotizing | 2 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5|
| 6| 0| 0| 0| 0| 0| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Macrophage | |
Alveolar Epithelium, Hyperplasia | 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 4 |
Nephropathy, Chronic | 1 2 2 3 2 2 2 4 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 5| 3| 3| | |
| 6| 1| 1| 1| 1| 1| 1| 6| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X | 3 |
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 2 3 | 3 2.3|
Bile Duct, Cyst | | 1 |
Hepatocyte, Fatty Change | | 5 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia | | 4 2.0|
Hypertrophy | 2 2 2 1 1 2 | 26 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Cyst | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicle, Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 5| 3| 3| | |
| 6| 1| 1| 1| 1| 1| 1| 6| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Developmental Malformation | | 1 |
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 54 |
Inflammation, Chronic Active | | 4 3.0|
Duct, Dilatation | 4 2 2 3 | 16 2.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Developmental Malformation | | 1 |
Interstitial Cell, Hyperplasia | | 2 2.0|
Seminiferous Tubule, Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 57 |
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Hyperplasia, Histiocytic, Macrophage | 2 2 2 2 2 2 2 | 44 2.1|
Infiltration Cellular, Histiocyte | 2 2 | 9 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | | 4 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
Depletion Lymphoid | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Maxilla, Inflammation, Chronic | | |
Active, Necrotizing | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 5| 3| 3| | |
| 6| 1| 1| 1| 1| 1| 1| 6| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Macrophage | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hydronephrosis | | 1 4.0|
Nephropathy, Chronic | 2 2 2 2 2 2 1 2 2 2 | 60 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 5| 2| 5| 2| 0| 2| 2| 2| 5|
| 9| 9| 9| 9| 9| 9| 9| 9| 6| 4| 9| 9| 9| 6| 9| 9| 6| 9| 6| 9| 1| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Necrosis | |
Thrombosis | |
Vacuolization Cytoplasmic | 1 |
Bile Duct, Hyperplasia | |
Hepatocyte, Fatty Change | 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ventricle Right, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 1 1 1 1 1 2 2 2 2 2 2 |
Vacuolization Cytoplasmic | |
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | X |
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 5| 2| 5| 2| 0| 2| 2| 2| 5|
| 9| 9| 9| 9| 9| 9| 9| 9| 6| 4| 9| 9| 9| 6| 9| 9| 6| 9| 6| 9| 1| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + M + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic Active | 3 3 |
Duct, Dilatation | 2 2 2 2 4 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 2 |
Seminiferous Tubule, Mineralization | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 |
Infiltration Cellular, Histiocyte | 1|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + M + + + M|
Depletion Lymphoid | 3 |
Hyperplasia, Histiocytic, Macrophage | 3 2 3 3 2 2 2 3 3 3 3 2 3 3 2 2 2 |
Infiltration Cellular, Histiocyte | 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + M + + M + +|
Cyst | |
Depletion Lymphoid | 2 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 |
Thoracic, Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 5| 2| 5| 2| 0| 2| 2| 2| 5|
| 9| 9| 9| 9| 9| 9| 9| 9| 6| 4| 9| 9| 9| 6| 9| 9| 6| 9| 6| 9| 1| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2|
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 2 2 2 2 2 |
Subpleura, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 2 3 2 3 2 3 2 2 2 2 2 1 2 2 1 1 2 2 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4|
DAY ON TEST | 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 5| 3| 3| 5|
| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Necrosis | |
Thrombosis | X |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 3 |
Hepatocyte, Fatty Change | 1 1 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ventricle Right, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 1 2 2 3 2 1 2 1 2 2 |
Vacuolization Cytoplasmic | |
Capsule, Accessory Adrenal Cortical | |
Nodule | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Craniopharyngeal Duct, Cyst | |
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4|
DAY ON TEST | 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 5| 3| 3| 5|
| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Duct, Dilatation | 3 2 2 2 2 2 2 2 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + M + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 3 |
Hyperplasia, Histiocytic, Macrophage | 3 3 3 3 2 2 3 2 3 3 2 3 3 3 3 2 3 3 3 3 3 3 |
Infiltration Cellular, Histiocyte | 2 3 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | 4 2 2 |
Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + M + + + M|
Cyst | X |
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
Thoracic, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + M + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4|
DAY ON TEST | 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 5| 3| 3| 5|
| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 2 2 |
Subpleura, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + M + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 4| 6| 7| | |
DAY ON TEST | 5| 7| 3| 3| 3| 3| 3| 5| 3| 3| | |
| 6| 0| 0| 0| 0| 0| 0| 6| 8| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Necrosis | 3 | 1 3.0|
Thrombosis | | 1 |
Vacuolization Cytoplasmic | | 1 1.0|
Bile Duct, Hyperplasia | | 1 3.0|
Hepatocyte, Fatty Change | | 6 1.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 1 | 2 1.5|
Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Ventricle Right, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hypertrophy | 2 2 1 1 | 25 1.6|
Vacuolization Cytoplasmic | 3 | 1 3.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 4| 6| 7| | |
DAY ON TEST | 5| 7| 3| 3| 3| 3| 3| 5| 3| 3| | |
| 6| 0| 0| 0| 0| 0| 0| 6| 8| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Craniopharyngeal Duct, Cyst | | 1 |
Pars Distalis, Cyst | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + M + | 51 |
Inflammation, Chronic Active | | 2 3.0|
Duct, Dilatation | 2 | 19 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Seminiferous Tubule, Atrophy | 3 | 2 2.5|
Seminiferous Tubule, Mineralization | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + | 58 |
Infiltration Cellular, Plasma Cell | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + M + | 55 |
Depletion Lymphoid | | 3 2.7|
Hyperplasia, Histiocytic, Macrophage | 3 3 3 2 3 2 | 45 2.7|
Infiltration Cellular, Histiocyte | 2 3 | 8 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Depletion Lymphoid | | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 5 2.6|
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 54 |
Cyst | | 1 |
Depletion Lymphoid | 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05165-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL) Date: 04/24/97
Route: DOSED FEED Time: 13:15:03
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 4| 6| 7| | |
DAY ON TEST | 5| 7| 3| 3| 3| 3| 3| 5| 3| 3| | |
| 6| 0| 0| 0| 0| 0| 0| 6| 8| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
Thoracic, Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 2 | 10 1.9|
Subpleura, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy, Chronic | 1 2 2 2 2 2 2 2 | 56 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
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