TDMS Study 05165-01 Pathology Tables
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
Facility: Battelle Columbus Laboratory
Chemical CAS #: 96-69-5
Lock Date: 12/26/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 10 50 10 50 10
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund Sacrifice 11 14 16
Natural Death 5 5 2
Survivors
Terminal Sacrifice 34 30 32
Natural Death 1
Animals Examined Microscopically 50 10 50 10 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (10) (50) (10) (50) (10)
Intestine Small, Duodenum (50) (10) (50) (10) (50) (10)
Liver (50) (10) (50) (10) (50) (10)
Mesentery (9) (1) (7) (2) (8)
Schwannoma Malignant 1 (14%)
Pancreas (50) (10) (50) (10) (50) (10)
Pharynx (1) (2)
Palate, Squamous Cell Papilloma 1 (100%) 2 (100%)
Salivary Glands (49) (10) (49) (10) (50) (10)
Stomach, Glandular (50) (10) (50) (10) (50) (10)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
Tooth (2) (1)
Gingiva, Squamous Cell Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (50) (10) (50) (10)
Schwannoma Malignant, Moderately Well
Differentiated 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (10) (50) (10) (50) (10)
Adenoma 1 (2%) 1 (2%)
Adrenal Medulla (50) (10) (50) (10) (49) (10)
Pheochromocytoma Benign 1 (2%) 1 (2%) 3 (6%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Page 2
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Islets, Pancreatic (50) (10) (50) (10) (50) (10)
Carcinoma 1 (2%)
Pituitary Gland (49) (10) (50) (10) (50) (10)
Pars Distalis, Adenoma 27 (55%) 3 (30%) 15 (30%) 1 (10%) 17 (34%)
Thyroid Gland (49) (10) (49) (10) (50) (10)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 3 (6%) 2 (4%) 7 (14%)
C-Cell, Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (10) (48) (10) (50) (10)
Adenoma 4 (8%) 1 (2%)
Carcinoma 1 (2%) 1 (2%)
Ovary (50) (10) (50) (10) (50) (10)
Uterus (50) (10) (50) (10) (50) (10)
Polyp Stromal 2 (4%) 5 (10%) 9 (18%) 1 (10%)
Sarcoma Stromal 1 (2%)
Vagina (2)
Fibrosarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (10) (50) (10) (50) (10)
Lymph Node (14) (10) (10)
Lymph Node, Mandibular (49) (10) (49) (10) (50) (10)
Lymph Node, Mesenteric (50) (10) (50) (10) (50) (10)
Spleen (50) (10) (50) (10) (50) (10)
Thymus (47) (10) (49) (10) (47) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (10) (50) (10) (50) (10)
Adenocarcinoma 1 (2%)
Adenoma 2 (4%) 1 (2%)
Fibroadenoma 18 (36%) 14 (28%) 1 (10%) 9 (18%)
Fibroadenoma, Multiple 11 (22%) 10 (20%) 2 (4%)
Skin (50) (10) (50) (10) (50) (10)
Squamous Cell Papilloma 1 (2%)
Page 3
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (10) (50) (10) (50) (10)
Cervical, Vertebra, Hemangiosarcoma 1 (2%)
Femur, Osteosarcoma 1 (2%)
Skeletal Muscle (50) (10) (50) (10) (50) (10)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (50) (10) (50) (10)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10) (49) (10) (49) (10)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Fibrosarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (50) (10) (50) (10) (50) (10)
Squamous Cell Carcinoma, Metastatic, Tooth 1 (2%)
Trachea (50) (10) (50) (10) (50) (10)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Fibrosarcoma 1 (100%)
Harderian Gland (49) (10) (50) (10) (50) (10)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10) (50) (10) (50) (10)
Urinary Bladder (50) (10) (49) (10) (50) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(10) *(50) *(10) *(50) *(10)
Leukemia Mononuclear 18 (36%) 18 (36%) 22 (44%)
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(10) *(50) *(10) *(50) *(10)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 3 45 2 43 1
Total Primary Neoplasms 98 3 76 2 78 1
Total Animals with Benign Neoplasms 42 3 35 2 36 1
Total Benign Neoplasms 75 3 52 2 52 1
Total Animals with Malignant Neoplasms 22 23 24
Total Malignant Neoplasms 23 24 26
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 3 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 10
Scheduled Sacrifice 10
Early Deaths
Moribund Sacrifice 16
Natural Death 6
Survivors
Terminal Sacrifice 28
Animals Examined Microscopically 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (10)
Intestine Large, Cecum (49) (9)
Intestine Small, Duodenum (49) (10)
Intestine Small, Jejunum (49) (10)
Adenocarcinoma 1 (2%)
Intestine Small, Ileum (49) (10)
Liver (50) (10)
Hepatocellular Adenoma 1 (2%)
Mesentery (4)
Pancreas (49) (10)
Stomach, Forestomach (49) (10)
Stomach, Glandular (49) (10)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (10)
Adrenal Medulla (50) (10)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%)
Pituitary Gland (49) (10)
Pars Distalis, Adenoma 16 (33%) 1 (10%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (50) (10)
C-Cell, Adenoma 8 (16%)
Page 7
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
C-Cell, Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (10)
Adenoma 1 (2%)
Carcinoma 2 (4%)
Ovary (50) (10)
Uterus (50) (10)
Polyp Stromal 9 (18%)
Sarcoma Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10)
Lymph Node (10)
Lymph Node, Mandibular (50) (10)
Lymph Node, Mesenteric (50) (10)
Spleen (50) (10)
Thymus (48) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (10)
Fibroadenoma 14 (28%)
Fibroadenoma, Multiple 2 (4%)
Skin (50) (10)
Subcutaneous Tissue, Fibroma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (50) (10)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10)
Spinal Cord (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10)
Alveolar/Bronchiolar Adenoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10)
Urinary Bladder (50) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(10)
Leukemia Mononuclear 20 (40%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 1
Total Primary Neoplasms 83 1
Total Animals with Benign Neoplasms 38 1
Total Benign Neoplasms 55 1
Total Animals with Malignant Neoplasms 25
Total Malignant Neoplasms 28
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 10
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 10 50 10 50 10
Scheduled Sacrifice 10 10 7
Early Deaths
Moribund Sacrifice 23 14 22 3
Natural Death 9 8 6
Survivors
Terminal Sacrifice 18 28 22
Animals Examined Microscopically 50 10 50 10 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (10) (50) (10) (50) (10)
Polyp Adenomatous 1 (2%)
Intestine Large, Rectum (50) (10) (50) (10) (50) (10)
Adenocarcinoma 1 (2%)
Intestine Small, Jejunum (50) (10) (50) (10) (50) (10)
Adenocarcinoma 1 (2%)
Liver (50) (10) (50) (10) (50) (10)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 2 (4%) 2 (4%)
Hepatocellular Adenoma, Multiple 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (11) (2) (7) (1) (10) (1)
Histiocytic Sarcoma 1 (10%)
Liposarcoma 1 (14%)
Pancreas (50) (10) (50) (10) (50) (10)
Histiocytic Sarcoma 1 (2%)
Pharynx (1) (1)
Squamous Cell Papilloma 1 (100%)
Palate, Squamous Cell Papilloma 1 (100%)
Salivary Glands (49) (10) (50) (10) (50) (10)
Stomach, Forestomach (50) (10) (50) (10) (50) (10)
Leiomyosarcoma 1 (2%)
Stomach, Glandular (50) (10) (50) (10) (50) (10)
Tongue (1) (2) (1)
Squamous Cell Papilloma 1 (100%) 1 (50%) 1 (100%)
Tooth (1)
Peridontal Tissue, Fibrosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (50) (10) (50) (10)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (10) (50) (10) (50) (10)
Adrenal Medulla (50) (10) (50) (10) (50) (10)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 11 (22%) 1 (10%) 12 (24%) 1 (10%) 7 (14%)
Bilateral, Pheochromocytoma Benign 3 (6%) 2 (4%) 3 (6%)
Islets, Pancreatic (50) (10) (50) (10) (50) (10)
Adenoma 2 (4%) 1 (10%)
Carcinoma 1 (2%) 1 (2%)
Parathyroid Gland (47) (10) (45) (10) (47) (10)
Adenoma 2 (4%)
Pituitary Gland (50) (10) (49) (10) (50) (10)
Histiocytic Sarcoma 1 (2%)
Pars Distalis, Adenoma 14 (28%) 1 (10%) 10 (20%) 2 (20%) 10 (20%) 1 (10%)
Pars Distalis, Adenoma, Multiple 2 (4%)
Pars Intermedia, Carcinoma 1 (2%)
Thyroid Gland (50) (10) (50) (10) (50) (10)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 4 (8%) 3 (6%) 8 (16%)
Follicular Cell, Adenoma 2 (4%) 1 (10%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (10) (50) (10) (50) (10)
Preputial Gland (50) (10) (49) (10) (49) (10)
Adenoma 1 (2%) 4 (8%) 2 (4%)
Carcinoma 2 (4%) 2 (4%)
Histiocytic Sarcoma 1 (2%)
Bilateral, Adenoma 1 (2%) 1 (2%)
Prostate (49) (10) (50) (10) (50) (10)
Seminal Vesicle (49) (10) (50) (10) (50) (10)
Testes (50) (10) (49) (10) (50) (10)
Bilateral, Interstitial Cell, Adenoma 36 (72%) 5 (50%) 38 (78%) 5 (50%) 42 (84%) 2 (20%)
Interstitial Cell, Adenoma 10 (20%) 1 (10%) 6 (12%) 3 (30%) 5 (10%) 4 (40%)
____________________________________________________________________________________________________________________________________
Page 12
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10) (50) (10) (50) (10)
Femoral, Histiocytic Sarcoma 1 (2%)
Maxilla, Histiocytic Sarcoma 1 (2%)
Lymph Node (24) (19) (26)
Mediastinal, Histiocytic Sarcoma 1 (4%)
Pancreatic, Histiocytic Sarcoma 1 (4%)
Renal, Leiomyosarcoma, Metastatic, Stomach,
Forestomach 1 (4%)
Lymph Node, Mandibular (48) (10) (50) (10) (50) (10)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (50) (10) (50) (10) (49) (10)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (10) (50) (10) (49) (10)
Fibrosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (48) (10) (46) (10) (46) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (10) (47) (10) (46) (10)
Adenoacanthoma 1 (2%)
Fibroadenoma 3 (6%) 4 (9%)
Skin (50) (10) (50) (10) (50) (10)
Basosquamous Tumor Benign 1 (2%)
Histiocytic Sarcoma 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%) 1 (2%)
Squamous Cell Papilloma 2 (4%) 1 (2%)
Sebaceous Gland, Adenocarcinoma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 5 (10%) 1 (2%) 4 (8%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%)
Subcutaneous Tissue, Neurofibroma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (10) (50) (10) (50) (10)
Cranium, Chondrosarcoma 1 (2%)
Cranium, Hemangiosarcoma 1 (10%)
Cranium, Osteosarcoma 1 (2%)
Femur, Histiocytic Sarcoma 1 (2%)
Femur, Osteosarcoma 1 (2%)
Maxilla, Histiocytic Sarcoma 1 (2%)
Skeletal Muscle (50) (10) (50) (10) (50) (10)
Page 13
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (50) (10) (50) (10)
Astrocytoma Malignant 2 (4%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Spinal Cord (2) (2) (3) (1)
Astrocytoma Malignant 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (10) (50) (10) (50) (10)
Adenocarcinoma, Metastatic, Zymbal's Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mediastinum, Schwannoma Malignant 1 (2%)
Nose (50) (10) (50) (10) (50) (10)
Chondrosarcoma, Metastatic, Bone 1 (2%)
Squamous Cell Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1) (2)
Fibrosarcoma 1 (100%)
Eye (3) (2) (5)
Lids, Left, Fibroma 1 (20%)
Harderian Gland (49) (10) (49) (9) (50) (10)
Zymbal's Gland (1) (1) (1)
Adenocarcinoma 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10) (50) (10) (50) (10)
Urinary Bladder (49) (10) (50) (10) (50) (10)
Page 14
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(10) *(50) *(10) *(50) *(10)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 30 (60%) 36 (72%) 34 (68%)
Mesothelioma Malignant 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 15
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
65 PATH 65 PATH 65 PATH
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 7 49 9 50 9
Total Primary Neoplasms 143 8 144 14 137 9
Total Animals with Benign Neoplasms 49 7 47 9 50 7
Total Benign Neoplasms 99 8 93 14 92 7
Total Animals with Malignant Neoplasms 37 41 39 2
Total Malignant Neoplasms 44 51 45 2
Total Animals with Metastatic Neoplasms 3 1 1
Total Metastatic Neoplasm 3 1 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 16
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 10
Scheduled Sacrifice 10
Early Deaths
Moribund Sacrifice 23
Natural Death 9
Survivors
Terminal Sacrifice 18
Animals Examined Microscopically 49 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (10)
Intestine Large, Cecum (49) (10)
Intestine Small, Ileum (49) (10)
Carcinoma, Metastatic, Kidney 1 (2%)
Liver (49) (10)
Carcinoma, Metastatic, Kidney 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 4 (8%)
Mesentery (9)
Pancreas (49) (10)
Carcinoma, Metastatic, Kidney 1 (2%)
Salivary Glands (49) (10)
Carcinoma, Metastatic, Kidney 1 (2%)
Stomach, Forestomach (49) (10)
Stomach, Glandular (49) (10)
Tongue (1)
Carcinoma, Metastatic, Kidney 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (10)
Carcinoma, Metastatic, Kidney 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (10)
Carcinoma, Metastatic, Kidney 1 (2%)
Adrenal Medulla (49) (10)
Carcinoma, Metastatic, Kidney 1 (2%)
Page 17
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Benign 9 (18%) 1 (10%)
Bilateral, Pheochromocytoma Malignant 1 (2%)
Parathyroid Gland (46) (10)
Adenoma 1 (2%)
Pituitary Gland (49) (10)
Pars Distalis, Adenoma 9 (18%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Thyroid Gland (49) (10)
Carcinoma, Metastatic, Kidney 1 (2%)
C-Cell, Adenoma 2 (4%) 1 (10%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (10)
Preputial Gland (49) (10)
Adenoma 4 (8%)
Prostate (48) (10)
Carcinoma, Metastatic, Kidney 1 (2%)
Seminal Vesicle (48) (10)
Testes (49) (10)
Bilateral, Interstitial Cell, Adenoma 31 (63%) 3 (30%)
Interstitial Cell, Adenoma 13 (27%) 3 (30%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (10)
Lymph Node (30)
Mediastinal, Carcinoma, Metastatic, Kidney 1 (3%)
Lymph Node, Mandibular (49) (10)
Lymph Node, Mesenteric (48) (10)
Carcinoma, Metastatic, Kidney 1 (2%)
Spleen (49) (10)
Thymus (46) (10)
____________________________________________________________________________________________________________________________________
Page 18
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (10)
Fibroadenoma 2 (4%)
Skin (48) (10)
Keratoacanthoma 2 (4%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Neurofibroma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (49) (10)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (10)
Astrocytoma Malignant 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (10)
Carcinoma, Metastatic, Kidney 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Nose (49) (10)
Carcinoma, Metastatic, Kidney 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (10)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (48) (10)
Page 19
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(49) *(10)
Leukemia Mononuclear 33 (67%)
Mesothelioma Benign 1 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 20
NTP Experiment-Test: 05165-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:15:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2500 PPM 2500 PPM
65 PATH
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 7
Total Primary Neoplasms 123 9
Total Animals with Benign Neoplasms 46 7
Total Benign Neoplasms 83 9
Total Animals with Malignant Neoplasms 37
Total Malignant Neoplasms 40
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 15
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 21
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---------- END OF REPORT ----------
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NTP Experiment-Test: 05165-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:32:54
Facility: Battelle Columbus Laboratory
Chemical CAS #: 96-69-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05165-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:32:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
NEURO HCU NEURO HCU NEURO HCU
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 40 15 40 15 40 15
Scheduled Sacrifice 40 15 40 15 40 12
Early Deaths
Natural Death 2
Moribund Sacrifice 1
Survivors
Animals Examined Microscopically 20 20 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05165-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:32:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 500 PPM 500 PPM 1000 PPM 1000 PPM
NEURO HCU NEURO HCU NEURO HCU
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
Page 3
NTP Experiment-Test: 05165-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:32:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2500 PPM 2500 PPM
NEURO HCU
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 40 15
Scheduled Sacrifice 40 14
Early Deaths
Moribund Sacrifice 1
Survivors
Animals Examined Microscopically 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05165-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) Date: 11/10/95
Route: DOSED FEED Time: 16:32:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2500 PPM 2500 PPM
NEURO HCU
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
Page 5
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---------- END OF REPORT ----------
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