TDMS Study 05165-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) DATE: 11/09/95
EXPERIMENT: 05165 TEST: 01 TIME: 20:00:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-65156 ROUTE: DOSED FEED NTP C#: 61610B
PATHOLOGIST: J. TOFT CAS: 96-69-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) DATE: 11/09/95
EXPERIMENT: 05165 TEST: 01 TIME: 20:00:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-65156 ROUTE: DOSED FEED NTP C#: 61610B
PATHOLOGIST: J. TOFT CAS: 96-69-5
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 32 CENSORED DEATHS 0 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 312 418 443 467 517 530 533 547 564 579 |
| 589 596 605 619 621 625 625 625 632 632 |
| 633 648 656 660 663 676 678 688 688 723 |
| 725 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 PPM 65 PATH |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 449 449 449 449 449 449 449 449 449 449 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 352 416 452 488 505 513 589 610 625 642 |
| 649 649 650 663 669 673 676 677 695 708 |
| 712 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 500 PPM 65 PATH |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 449 449 449 449 449 449 449 449 449 449 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 416 450 466 477 555 561 592 599 604 610 |
| 627 633 639 650 652 653 660 688 688 688 |
| 695 697 698 703 709 719 723 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 PPM 65 PATH |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 3 CENSORED DEATHS 7 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 403 410 410 |
| CENSORED DEATHS |
| 449 449 449 449 449 449 449 |
| |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 32 CENSORED DEATHS 0 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 423 441 484 533 539 555 555 555 566 571 |
| 576 603 604 604 621 625 633 645 649 649 |
| 649 652 656 663 673 677 677 695 695 698 |
| 712 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM 65 PATH |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 449 449 449 449 449 449 449 449 449 449 |
| |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 98.0 96.0 92.0 86.0 74.0 50.0 36.0 |
| | |
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|PPM 65 P|TH |
| | |
|500 PPM | 100.0 100.0 100.0 98.0 96.0 94.0 88.0 86.0 72.0 56.0 |
| | |
| | |
|500 | 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|PPM 65 PAT| |
| | |
|1000 PPM | 100.0 100.0 100.0 100.0 98.0 92.0 92.0 82.0 66.0 44.0 |
| | |
| | |
|1000 | 100.0 100.0 100.0 100.0 70.0 0.0 0.0 0.0 0.0 0.0 |
|PPM 65 PATH| |
| | |
|2500 PPM | 100.0 100.0 100.0 100.0 98.0 94.0 90.0 72.0 52.0 36.0 |
| | |
| | |
|2500 | 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|PPM 65 PATH| |
| | |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 0 500 PPM 500 1000 PPM 1000 2500 PPM 2500 |
| PPM 65 PA H PPM 65 PATH PPM 65 PATH PPM 65 PA|H
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 36.0% 0.0% 56.0% 0.0% 44.0% 0.0% 36.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.506 ----- P=0.049N P=0.989N P=0.303N P=0.066 P=1.000N P=0.989N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 601.3 . 606.3 . 627.8 407.7 612.5 . |
|NATURAL DEATHS (C) | (16.6) ( . ) (22.3) ( . ) (16.5) ( 2.3) (13.3) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 647.3 449.0 675.0 449.0 672.3 436.6 654.5 449.0 |
|(STANDARD ERROR) | (13.7) ( 0.0) (13.0) ( 0.0) (11.6) ( 6.3) (11.6) ( 0.0) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 453 518 536 623 651 663 673 673 673 676 |
| 709 715 721 725 725 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 PPM 65 PATH |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 450 450 450 450 450 450 450 450 450 450 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 372 428 590 591 604 605 624 626 652 663 |
| 665 677 677 688 688 688 697 712 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 500 PPM 65 PATH |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 450 450 450 450 450 450 450 450 450 450 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 14 481 539 555 592 598 598 626 633 649 |
| 680 688 688 695 695 712 723 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 PPM 65 PATH |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 450 450 450 450 450 450 450 450 450 450 |
| |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 452 491 518 541 572 572 591 597 604 605 |
| 620 641 660 663 663 688 688 697 698 711 |
| 715 719 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM 65 PATH |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 450 450 450 450 450 450 450 450 450 450 |
| |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 94.0 88.0 68.0 |
| | |
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|PPM 65 P|TH |
| | |
|500 PPM | 100.0 100.0 100.0 100.0 98.0 96.0 96.0 88.0 78.0 62.0 |
| | |
| | |
|500 | 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|PPM 65 PAT| |
| | |
|1000 PPM | 98.0 98.0 98.0 98.0 98.0 96.0 94.0 86.0 80.0 64.0 |
| | |
| | |
|1000 | 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|PPM 65 PATH| |
| | |
|2500 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 92.0 80.0 70.0 56.0 |
| | |
| | |
|2500 | 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|PPM 65 PATH| |
| | |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 0 500 PPM 500 1000 PPM 1000 2500 PPM 2500 |
| PPM 65 PA H PPM 65 PATH PPM 65 PATH PPM 65 PA|H
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 0.0% 62.0% 0.0% 64.0% 0.0% 56.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.202 ----- P=0.558 ----- P=0.711 ----- P=0.195 ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 653.9 . 630.1 . 604.9 . 623.0 . |
|NATURAL DEATHS (C) | (20.6) ( . ) (20.9) ( . ) (38.3) ( . ) (16.2) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 705.0 450.0 691.4 450.0 684.3 450.0 682.4 450.0 |
|(STANDARD ERROR) | ( 8.2) ( 0.0) (10.4) ( 0.0) (16.0) ( 0.0) (10.3) ( 0.0) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
0 PPM 65 PATH = 2
500 PPM = 3
500 PPM 65 PATH = 4
1000 PPM = 5
1000 PPM 65 PATH = 6
2500 PPM = 7
2500 PPM 65 PATH = 8
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 6 17 7 2
| 1 71 3 1 53 7
P | 66 1 53 31 11 55 3
E | 1 171 3553 3
R 80 + 171 1155 3533
C | 11 1 553 3
E | 6 6 7 117 55 333
N | 11 7 5 3 53
T 60 + 1 17 53 3 3
| 11 1 55 3 3
S | 1 1 5555
U | 1 17 5 5
R 40 + 17 7 1
V | 1 1
I |
V |
A 20 +
L |
|
|
0 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 79 obs hidden.
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
0 PPM 65 PATH = 2
500 PPM = 3
500 PPM 65 PATH = 4
1000 PPM = 5
1000 PPM 65 PATH = 6
2500 PPM = 7
2500 PPM 65 PATH = 8
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 5 3 3 1 5 7 1
| 3 5 7 1 17 5 3 1
P | 7 5 7 353 13 1 1 1
E | 757 35 3
R 80 + 7 7 5753 3 155 11
C | 7 7 3 35 11
E | 7 33 5 1 1
N | 73 3 3 5
T 60 + 7 773 3
| 7 7
S |
U |
R 40 +
V |
I |
V |
A 20 +
L |
|
|
0 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 50 obs hidden.
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) DATE: 11/09/95
EXPERIMENT: 05165 TEST: 03 TIME: 21:05:21
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-65156 ROUTE: DOSED FEED NTP C#: 61610B
PATHOLOGIST: J. TOFT CAS: 96-69-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus 4,4 THIOBIS-(6-T-BUTYL-M-CRESOL) DATE: 11/09/95
EXPERIMENT: 05165 TEST: 03 TIME: 21:05:21
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-65156 ROUTE: DOSED FEED NTP C#: 61610B
PATHOLOGIST: J. TOFT CAS: 96-69-5
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM NEURO |
| ---------------------------- |
| |
| TOTAL 40 UNCENSORED DEATHS 0 CENSORED DEATHS 40 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 99 99 99 99 99 99 100 100 100 100 |
| 100 100 102 103 106 107 108 109 110 113 |
| 183 184 185 186 190 190 190 190 190 190 |
| 191 191 191 191 191 191 193 194 197 198 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 PPM HCU |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 15 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 PPM NEURO |
| ---------------------------- |
| |
| TOTAL 40 UNCENSORED DEATHS 0 CENSORED DEATHS 40 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 99 99 99 99 99 99 100 100 100 100 |
| 100 100 102 103 106 107 108 109 110 113 |
| 183 184 185 186 190 190 190 190 190 190 |
| 191 191 191 191 191 192 193 194 197 198 |
| |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 500 PPM HCU |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 15 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 PPM NEURO |
| ---------------------------- |
| |
| TOTAL 40 UNCENSORED DEATHS 0 CENSORED DEATHS 40 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 99 99 99 99 99 99 100 100 100 100 |
| 100 100 102 103 106 107 108 109 110 113 |
| 183 184 185 186 190 190 190 190 190 190 |
| 191 191 191 191 191 192 193 194 197 198 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 PPM HCU |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 3 CENSORED DEATHS 12 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 250 277 368 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| 456 456 |
| |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2500 PPM NEURO |
| ---------------------------- |
| |
| TOTAL 40 UNCENSORED DEATHS 0 CENSORED DEATHS 40 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 99 99 99 99 99 99 100 100 100 100 |
| 100 100 102 103 106 107 108 109 110 113 |
| 183 184 185 186 190 190 190 190 190 190 |
| 191 191 191 191 191 192 193 194 197 198 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM HCU |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 14 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 330 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| 456 456 456 456 |
| |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 1E5 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|PPM NEUR| |
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|PPM HCU | |
| | |
|500 | 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|PPM NEURO | |
| | |
|500 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|PPM HCU | |
| | |
|1000 | 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|PPM NEURO | |
| | |
|1000 | 100.0 100.0 93.3 86.7 80.0 80.0 80.0 80.0 80.0 80.0 |
|PPM HCU | |
| | |
|2500 | 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|PPM NEURO | |
| | |
|2500 | 100.0 100.0 100.0 93.3 93.3 93.3 93.3 93.3 93.3 93.3 |
|PPM HCU | |
| | |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 0 500 500 1000 1000 2500 2500 |
| PPM NEUROPPM HCU PPM NEURO PPM HCU PPM NEURO PPM HCU PPM NEURO PPM HCU |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 0.0% 100.0% 0.0% 100.0% 0.0% 80.0% 0.0% 93.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.680 ----- ----- ----- ----- P=1.000N ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | . . . . . 298.3 . 330.0 |
|NATURAL DEATHS (C) | ( . ) ( . ) ( . ) ( . ) ( . ) (35.7) ( . ) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 146.5 456.0 146.5 456.0 146.5 424.5 146.5 447.6 |
|(STANDARD ERROR) | ( 7.1) ( 0.0) ( 7.1) ( 0.0) ( 7.1) (17.9) ( 7.1) ( 8.4) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM HCU |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 15 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 PPM HCU |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 15 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 PPM HCU |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 15 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| 457 457 457 457 457 |
| |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2500 PPM HCU |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 14 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 218 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| 457 457 457 457 |
| |
==================================================================================
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 1E5 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|PPM HCU | |
| | |
|500 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|PPM HCU | |
| | |
|1000 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|PPM HCU | |
| | |
|2500 | 100.0 100.0 93.3 93.3 93.3 93.3 93.3 93.3 93.3 93.3 |
|PPM HCU | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 500 1000 2500 |
| PPM HCU PPM HCU PPM HCU PPM HCU |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 100.0% 100.0% 100.0% 93.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.423 ----- ----- P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | . . . 218.0 |
|NATURAL DEATHS (C) | ( . ) ( . ) ( . ) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 457.0 457.0 457.0 441.1 |
|(STANDARD ERROR) | ( 0.0) ( 0.0) ( 0.0) (15.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
KAPLAN-MEIER SURVIVAL CURVES
0 PPM NEURO = 1
0 PPM HCU = 2
500 PPM NEURO = 3
500 PPM HCU = 4
1000 PPM NEURO = 5
1000 PPM HCU = 6
2500 PPM NEURO = 7
2500 PPM HCU = 8
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 8 2
| 6 6 8 8
P |
E | 6 6
R 80 + 6 6
C |
E |
N |
T 60 +
|
S |
U |
R 40 +
V |
I |
V |
A 20 +
L |
|
|
0 + 1
|
---+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+--
0 4 8 12 16 20 24 28 32 36 40 44 48 52 56 60 64 68
WEEK
NOTE: 15 obs hidden.
4,4 THIOBIS-(6-T-BUTYL-M-CRESOL)
KAPLAN-MEIER SURVIVAL CURVES
0 PPM HCU = 1
500 PPM HCU = 2
1000 PPM HCU = 3
2500 PPM HCU = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
(NOTE: 5 obs hidden.)
P |
E |
R 100.00 + 1 4 1
C |
E |
N |
T 93.33 + 4 4
|
S ---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
U 0 10 20 30 40 50 60 70
R
WEEK