TDMS Study 05166-01 Pathology Tables
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
Facility: Hazleton Laboratories America, Inc.
Chemical CAS #: 612-82-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous, | |
Multifocal | 1 |
Bile Duct, Hyperplasia | 2 2 2 1 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Cyst | X |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + +|
Duct, Ectasia | 2 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Hydrometra | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal, Re Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 3 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M + + M + + + + + + +|
Fibrosis, Focal | 2 |
Duct, Ectasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Brain Stem, Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Nephropathy | 1 2 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 1 1 1 1 |
Bile Duct, Hyperplasia | 1 1 1 2 1 2 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic, Focal | 3 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Angiectasis | |
Cyst | X X X X X |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal, Re Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | 2 |
__________________________________________________________________________|
Thymus | + + M + + M + + + + + + + + + + + + + + + M + + +|
Epithelial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + M + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 2 1 2 1 1 2 2 1 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 60 |
Parasite Metazoan | 2 | 4 1.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 60 |
Parasite Metazoan | 2 2 | 6 1.5|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 60 |
Hepatodiaphragmatic Nodule | X X | 7 |
Inflammation, Granulomatous, | | |
Multifocal | 1 1 1 | 11 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 | 20 1.3|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis, Focal | | 3 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
Acinus, Atrophy | 1 1 | 5 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 60 |
Degeneration, Cystic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 60 |
Vacuolization Cytoplasmic, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + M + + + + + + + | 53 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Angiectasis | | 1 1.0|
Cyst | X X X X X X X X X X X | 17 |
Pars Distalis, Hyperplasia, Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Ultimobranchial Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Duct, Ectasia | 2 | 6 2.2|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 60 |
Periovarian Tissue, Cyst | X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 60 |
Hydrometra | 2 2 | 5 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Multifocal, Re Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 60 |
Mediastinal, Hemorrhage | 2 2 2 2 2 2 | 21 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 60 |
Hemorrhage | 1 | 3 1.7|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Sinus, Ectasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 60 |
Hemorrhage, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + M M + + + + + + + | 54 |
Epithelial Cell, Hyperplasia | 2 2 2 2 | 7 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + | 56 |
Fibrosis, Focal | | 1 2.0|
Duct, Ectasia | | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 60 |
Brain Stem, Compression | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | 1 1 1 1 | 12 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 60 |
Hemorrhage | | 5 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 60 |
Nephropathy | 1 1 1 2 2 2 1 2 1 1 1 2 1 1 1 1 1 2 | 47 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 9| 5| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 1| 1| 1| 1| 2| 2| 2| 3| 7| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 6| 2| 2| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.003 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 1 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 2 1 1 |
Degeneration, Cystic | 2 2|
Eosinophilic Focus | 2 2 2 |
Hematopoietic Cell Proliferation | 2 1 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous, | |
Multifocal | 2 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2|
Necrosis, Coagulative, Focal | 1 |
Necrosis, Focal | |
Bile Duct, Hyperplasia | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + + + + + + +|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 9| 5| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 1| 1| 1| 1| 2| 2| 2| 3| 7| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 6| 2| 2| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.003 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 |
Cyst | X X X X X |
Hemorrhage | 3 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 |
Bilateral, Duct, Ectasia | 2 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Pigmentation, Focal, Hemosiderin | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 2 1 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 3 |
Sinus, Ectasia | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 9| 5| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 1| 1| 1| 1| 2| 2| 2| 3| 7| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 6| 2| 2| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.003 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 4 |
__________________________________________________________________________|
Thymus | + M + M + + + + M + + + + M + + + + + + + + M + +|
Cyst | X X |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
Cranium, Osteopetrosis | |
Sternum, Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 2 1|
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Focal, Glandular | 2 2 |
Hyperplasia, Focal, Squamous | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Karyomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy | 1 1 2 2 2 2 1 2 2 1 3 2 1 2 2 2 2 2 2 2 2 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 9| 2| 2| 2| 2| 9| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| | |
| 2| 2| 2| 6| 1| 2| 2| 5| 5| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.003 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 45 |
Parasite Metazoan | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 45 |
Parasite Metazoan | 1 | 7 1.4|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 45 |
Basophilic Focus | 1 1 1 1 1 2 1 1 | 13 1.2|
Degeneration, Cystic | 1 | 3 1.7|
Eosinophilic Focus | 2 2 2 1 | 7 2.0|
Hematopoietic Cell Proliferation | 2 1 1 1 | 7 1.3|
Hepatodiaphragmatic Nodule | X X X X X X | 7 |
Inflammation, Granulomatous, | | |
Multifocal | 1 1 1 1 1 1 | 19 1.1|
Mixed Cell Focus | 1 2 2 1 1 2 1 2 1 2 2 2 1 | 34 1.7|
Necrosis, Coagulative, Focal | | 1 1.0|
Necrosis, Focal | 4 2 | 2 3.0|
Bile Duct, Hyperplasia | 2 2 | 2 2.0|
Centrilobular, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Hemorrhage | 4 | 1 4.0|
Fat, Necrosis, Focal | 4 | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 45 |
Acinus, Atrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + | 43 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 45 |
Degeneration, Cystic | 1 | 3 1.0|
__________________________________________________________________________|____________|
Tongue | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 9| 2| 2| 2| 2| 9| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| | |
| 2| 2| 2| 6| 1| 2| 2| 5| 5| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.003 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 45 |
Coronary Artery, Inflammation, | | |
Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 45 |
Cyst | | 1 |
Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 45 |
Angiectasis | 2 3 | 6 2.2|
Cyst | X X | 7 |
Hemorrhage | 3 | 2 3.0|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 45 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | 45 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Bilateral, Duct, Ectasia | | 1 2.0|
Duct, Ectasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + M | 44 |
Cyst | X | 2 |
Periovarian Tissue, Cyst | X X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + M | 44 |
Hydrometra | 3 3 3 | 3 3.0|
Pigmentation, Focal, Hemosiderin | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 9| 2| 2| 2| 2| 9| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| | |
| 2| 2| 2| 6| 1| 2| 2| 5| 5| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.003 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 45 |
Mediastinal, Hemorrhage | 2 2 2 | 7 1.9|
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + | 43 |
Hemorrhage | 2 | 2 1.5|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Hyperplasia, Plasma Cell | 3 3 3 | 5 3.0|
Sinus, Ectasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 45 |
Hematopoietic Cell Proliferation | 4 4 3 | 6 3.8|
__________________________________________________________________________|____________|
Thymus | + + + + M + M M M M + + + + M + + M + M | 32 |
Cyst | | 2 |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 | 15 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + | 42 |
Duct, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 45 |
Acanthosis | 3 | 3 2.3|
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 2 |
Cranium, Osteopetrosis | 3 | 1 3.0|
Sternum, Osteopetrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 45 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 | 23 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 1 2 | 7 1.4|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + M + + + + + + + + + + | 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 9| 2| 2| 2| 2| 9| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| | |
| 2| 2| 2| 6| 1| 2| 2| 5| 5| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.003 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + M + + + + + + + + + + | 44 |
Cyst | | 1 |
Hyperplasia, Focal, Glandular | 2 | 3 2.0|
Hyperplasia, Focal, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 45 |
Karyomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.0|
Nephropathy | 2 2 2 1 1 1 2 2 2 2 1 2 2 2 2 1 1 2 2 | 44 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 3| 3| 1| 4| 4| 3| 3| 3|
DAY ON TEST | 2| 2| 2| 3| 1| 2| 1| 2| 2| 3| 2| 2| 0| 0| 0| 2| 0| 9| 7| 8| 2| 2| 9| 7| 7|
| 1| 1| 1| 8| 5| 1| 9| 1| 2| 8| 2| 2| 6| 5| 6| 2| 6| 0| 0| 4| 2| 2| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Parasite Metazoan | 2 1 1 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Mineralization | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 1 1 2 1 2 1 |
Degeneration, Chronic | |
Degeneration, Cystic | 2 |
Eosinophilic Focus | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 3 |
Fatty Change, Multifocal | |
Hematopoietic Cell Proliferation | 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Acute, Multifocal | 1 |
Inflammation, Granulomatous, | |
Multifocal | 1 2 1 1|
Mixed Cell Focus | 3 3 2 2 2 2 2 2 2 2 2 2 3 2 1 1 2 1 3 2 3|
Necrosis, Coagulative, Multifocal | |
Necrosis, Focal | 3 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | |
Artery, Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia, Focal | |
Artery, Mineralization | |
__________________________________________________________________________|
Pharynx | + |
Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 3| 3| 1| 4| 4| 3| 3| 3|
DAY ON TEST | 2| 2| 2| 3| 1| 2| 1| 2| 2| 3| 2| 2| 0| 0| 0| 2| 0| 9| 7| 8| 2| 2| 9| 7| 7|
| 1| 1| 1| 8| 5| 1| 9| 1| 2| 8| 2| 2| 6| 5| 6| 2| 6| 0| 0| 4| 2| 2| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 |
Erosion | |
Erosion, Multifocal | 2 |
Mineralization | 3 |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
Hyperkeratosis, Focal | |
Artery, Mineralization | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 2 2 2 2 |
Bilateral, Angiectasis | |
Bilateral, Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X X |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mineralization | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 3| 3| 1| 4| 4| 3| 3| 3|
DAY ON TEST | 2| 2| 2| 3| 1| 2| 1| 2| 2| 3| 2| 2| 0| 0| 0| 2| 0| 9| 7| 8| 2| 2| 9| 7| 7|
| 1| 1| 1| 8| 5| 1| 9| 1| 2| 8| 2| 2| 6| 5| 6| 2| 6| 0| 0| 4| 2| 2| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | |
Hyperplasia | 2 |
Inflammation, Suppurative | |
Duct, Ectasia | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Periovarian Tissue, Cyst | |
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hydrometra | 2 |
Cervix, Dilatation | |
Endometrium, Cyst | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Anemia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Hyperplasia, Plasma | |
Cell | 3 |
Inguinal, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mediastinal, Sinus, Infiltration | |
Cellular, Histiocyte | |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + M + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 3 3 3 3 3 3 |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis, Focal | |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 3 4 3 4 |
Pigmentation, Hemosiderin | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 3| 3| 1| 4| 4| 3| 3| 3|
DAY ON TEST | 2| 2| 2| 3| 1| 2| 1| 2| 2| 3| 2| 2| 0| 0| 0| 2| 0| 9| 7| 8| 2| 2| 9| 7| 7|
| 1| 1| 1| 8| 5| 1| 9| 1| 2| 8| 2| 2| 6| 5| 6| 2| 6| 0| 0| 4| 2| 2| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + M + + + +|
Epithelial Cell, Hyperplasia | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Epidermis, Hyperplasia, Basal Cell, | |
Focal | 1 |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Cranium, Fibrous Osteodystrophy | |
Sternum, Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | |
Brain Stem, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Metaplasia, Focal, Osseous | |
Metaplasia, Squamous | |
Mineralization | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 1 2 2 1 2 1 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 1 2 1 2|
Artery, Mineralization | |
Interstitium, Inflammation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 |
Hemorrhage | 2 2 |
Inflammation, Suppurative | 3 |
Olfactory Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 3| 3| 1| 4| 4| 3| 3| 3|
DAY ON TEST | 2| 2| 2| 3| 1| 2| 1| 2| 2| 3| 2| 2| 0| 0| 0| 2| 0| 9| 7| 8| 2| 2| 9| 7| 7|
| 1| 1| 1| 8| 5| 1| 9| 1| 2| 8| 2| 2| 6| 5| 6| 2| 6| 0| 0| 4| 2| 2| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Anterior Chamber, Hemorrhage | 4|
Cornea, Inflammation, Suppurative | 4|
__________________________________________________________________________|
Harderian Gland | |
Pigmentation, Porphyrin | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia, Focal, Glandular | 3 |
Hyperplasia, Focal, Squamous | 2 |
Hypertrophy | |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Karyomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 2 3 4 3 2 2 3 4 4 3 2 2 3 3 3 3 4 4 4 1 3 3 3 4 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 3| 3| 4| 4| 3| 3| 3| 4| 4| 3| 3| 1| 4| 4| 4| 3| 3| 4| 4| 3| 3| 2|
DAY ON TEST | 2| 2| 0| 6| 5| 2| 0| 1| 1| 0| 2| 2| 8| 1| 4| 2| 2| 0| 9| 9| 2| 0| 6| 6| 2|
| 2| 6| 6| 4| 5| 2| 6| 5| 5| 9| 2| 2| 4| 0| 2| 2| 2| 9| 1| 1| 2| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3 |
Parasite Metazoan | 1 1 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + M +|
Muscularis, Mineralization | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + M +|
Angiectasis | 2 2 2 |
Basophilic Focus | 1 2 |
Degeneration, Chronic | |
Degeneration, Cystic | 1 2 1 2 1 2 |
Eosinophilic Focus | 2 2 2 2 2 3 2 3 2 3 3 2 3 2 2 2 3 2|
Fatty Change, Multifocal | 1 1 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1|
Hepatodiaphragmatic Nodule | X X|
Inflammation, Acute, Multifocal | 1 |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 1 1 |
Mixed Cell Focus | 2 2 1 2 2 3 2 2 2 2 2 2 2 |
Necrosis, Coagulative, Multifocal | 2 |
Necrosis, Focal | 4 3 4 4 |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + |
Artery, Mineralization | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + M +|
Acinus, Atrophy | 2 |
Acinus, Hyperplasia, Focal | 2 |
Artery, Mineralization | 3 |
__________________________________________________________________________|
Pharynx | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 3| 3| 4| 4| 3| 3| 3| 4| 4| 3| 3| 1| 4| 4| 4| 3| 3| 4| 4| 3| 3| 2|
DAY ON TEST | 2| 2| 0| 6| 5| 2| 0| 1| 1| 0| 2| 2| 8| 1| 4| 2| 2| 0| 9| 9| 2| 0| 6| 6| 2|
| 2| 6| 6| 4| 5| 2| 6| 5| 5| 9| 2| 2| 4| 0| 2| 2| 2| 9| 1| 1| 2| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + M +|
Degeneration, Cystic | 2 |
Erosion | 3 |
Erosion, Multifocal | |
Mineralization | 4 3 3 4 |
Ulcer | 4 |
__________________________________________________________________________|
Tongue | + + |
Hyperkeratosis, Focal | 2 |
Artery, Mineralization | 3 |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Mineralization | 4 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + M +|
Angiectasis | 2 3 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 2 2 |
Bilateral, Angiectasis | |
Bilateral, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Cyst | X X X X |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
Mineralization | 4 3 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 3| 3| 4| 4| 3| 3| 3| 4| 4| 3| 3| 1| 4| 4| 4| 3| 3| 4| 4| 3| 3| 2|
DAY ON TEST | 2| 2| 0| 6| 5| 2| 0| 1| 1| 0| 2| 2| 8| 1| 4| 2| 2| 0| 9| 9| 2| 0| 6| 6| 2|
| 2| 6| 6| 4| 5| 2| 6| 5| 5| 9| 2| 2| 4| 0| 2| 2| 2| 9| 1| 1| 2| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | |
Hyperplasia | 2 2 |
Inflammation, Suppurative | 4 |
Duct, Ectasia | 2 3 3 3 3 3 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Periovarian Tissue, Cyst | X |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hydrometra | |
Cervix, Dilatation | 3 |
Endometrium, Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Anemia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + M + + +|
Atrophy | |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Hyperplasia, Plasma | |
Cell | |
Inguinal, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mediastinal, Sinus, Infiltration | |
Cellular, Histiocyte | |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 3 3 3 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +|
Atrophy | |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + M +|
Depletion Lymphoid | 2 |
Fibrosis, Focal | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 4 2 3 3 4 3 4 3|
Pigmentation, Hemosiderin | 3 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 3| 3| 4| 4| 3| 3| 3| 4| 4| 3| 3| 1| 4| 4| 4| 3| 3| 4| 4| 3| 3| 2|
DAY ON TEST | 2| 2| 0| 6| 5| 2| 0| 1| 1| 0| 2| 2| 8| 1| 4| 2| 2| 0| 9| 9| 2| 0| 6| 6| 2|
| 2| 6| 6| 4| 5| 2| 6| 5| 5| 9| 2| 2| 4| 0| 2| 2| 2| 9| 1| 1| 2| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + M +|
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Epidermis, Hyperplasia, Basal Cell, | |
Focal | |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
Cranium, Fibrous Osteodystrophy | 3 2 |
Sternum, Fibrous Osteodystrophy | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Compression | |
Brain Stem, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 |
Metaplasia, Focal, Osseous | |
Metaplasia, Squamous | |
Mineralization | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 1 2 1 1|
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 1 1 1 |
Artery, Mineralization | 3 |
Interstitium, Inflammation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Hemorrhage | |
Inflammation, Suppurative | 2 2 2 |
Olfactory Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 3| 3| 4| 4| 3| 3| 3| 4| 4| 3| 3| 1| 4| 4| 4| 3| 3| 4| 4| 3| 3| 2|
DAY ON TEST | 2| 2| 0| 6| 5| 2| 0| 1| 1| 0| 2| 2| 8| 1| 4| 2| 2| 0| 9| 9| 2| 0| 6| 6| 2|
| 2| 6| 6| 4| 5| 2| 6| 5| 5| 9| 2| 2| 4| 0| 2| 2| 2| 9| 1| 1| 2| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Anterior Chamber, Hemorrhage | 3 |
Cornea, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Harderian Gland | + |
Pigmentation, Porphyrin | 3 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 1 |
Hyperplasia, Focal, Glandular | 2 2 |
Hyperplasia, Focal, Squamous | 2 2 |
Hypertrophy | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + M +|
Karyomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy | 3 3 4 4 3 4 2 4 2 3 3 2 3 3 3 3 4 2 2 4 4 4 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 3| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 3| 3| 3| 3| |
DAY ON TEST | 2| 2| 6| 3| 2| 2| 2| 0| 9| 3| 2| 2| 2| 2| 8| 2| 2| 2| 2| 6| 2| 8| 6| 3| 2| |
| 2| 2| 5| 8| 7| 2| 2| 5| 0| 8| 2| 2| 2| 5| 3| 5| 5| 5| 6| 8| 5| 8| 3| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| 74 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Mineralization | | 2 2.5|
Parasite Metazoan | 3 | 9 1.8|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + + +| 74 |
Parasite Metazoan | 2 1| 5 1.8|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Muscularis, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Angiectasis | 2 2 | 6 2.0|
Basophilic Focus | 1 3 1 | 11 1.5|
Degeneration, Chronic | 1 | 1 1.0|
Degeneration, Cystic | 2 2 1 1 2 | 12 1.6|
Eosinophilic Focus | 2 2 3 2 2 2 2 2 2 3 2 2 2 1 3 2 2 1 2| 57 2.2|
Fatty Change, Multifocal | 1 1 | 4 1.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 | 19 1.0|
Hepatodiaphragmatic Nodule | X X X | 7 |
Inflammation, Acute, Multifocal | | 2 1.0|
Inflammation, Granulomatous, | | |
Multifocal | 1 | 10 1.1|
Mixed Cell Focus | 3 1 3 2 2 2 2 2 2 3 1 3 2 2 2| 49 2.1|
Necrosis, Coagulative, Multifocal | 2 | 2 2.0|
Necrosis, Focal | | 5 3.6|
Bile Duct, Cyst | X | 2 |
Bile Duct, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Artery, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Acinus, Atrophy | | 1 2.0|
Acinus, Hyperplasia, Focal | | 1 2.0|
Artery, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | + + + + + + + | 8 |
Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 3| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 3| 3| 3| 3| |
DAY ON TEST | 2| 2| 6| 3| 2| 2| 2| 0| 9| 3| 2| 2| 2| 2| 8| 2| 2| 2| 2| 6| 2| 8| 6| 3| 2| |
| 2| 2| 5| 8| 7| 2| 2| 5| 0| 8| 2| 2| 2| 5| 3| 5| 5| 5| 6| 8| 5| 8| 3| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| 72 |
Inflammation, Chronic | | 3 2.7|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Degeneration, Cystic | 1 1 | 6 1.3|
Erosion | 1 | 2 2.0|
Erosion, Multifocal | | 1 2.0|
Mineralization | | 5 3.4|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 3 |
Hyperkeratosis, Focal | | 1 2.0|
Artery, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Peridontal Tissue, Inflammation, | | |
Chronic Active | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + M + + + + + + + + + + + + + + + + + + + + +| 74 |
Cardiomyopathy | 1 1 | 3 1.0|
Mineralization | | 4 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Angiectasis | 2 2 | 8 2.1|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Focal | 2 | 3 2.0|
Vacuolization Cytoplasmic, Focal | 1 2 2 2 | 10 1.9|
Bilateral, Angiectasis | 1 | 1 1.0|
Bilateral, Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + + + + + + + M + + + + + + + + + + + +| 70 |
Hyperplasia | | 5 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Angiectasis | 2 2 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 3| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 3| 3| 3| 3| |
DAY ON TEST | 2| 2| 6| 3| 2| 2| 2| 0| 9| 3| 2| 2| 2| 2| 8| 2| 2| 2| 2| 6| 2| 8| 6| 3| 2| |
| 2| 2| 5| 8| 7| 2| 2| 5| 0| 8| 2| 2| 2| 5| 3| 5| 5| 5| 6| 8| 5| 8| 3| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | X X X | 11 |
Pars Distalis, Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 74 |
Ultimobranchial Cyst | X X X | 7 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + +| 6 |
Mineralization | | 4 3.5|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hyperplasia, Focal, Squamous | 3 | 1 3.0|
Hyperplasia | | 3 2.0|
Inflammation, Suppurative | | 1 4.0|
Duct, Ectasia | 3 2 3 | 12 2.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Bilateral, Periovarian Tissue, Cyst | | 1 |
Periovarian Tissue, Cyst | X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Fibrosis | | 1 3.0|
Hydrometra | | 1 2.0|
Cervix, Dilatation | | 1 3.0|
Endometrium, Cyst | X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Anemia | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + M + + + + + + + + + + + + + + + + +| 73 |
Atrophy | 3 | 1 3.0|
Hemorrhage | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Deep Cervical, Hyperplasia, Plasma | | |
Cell | | 1 3.0|
Inguinal, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mediastinal, Hemorrhage | 2 2 2 | 4 2.3|
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 2 | 2 2.0|
Mediastinal, Sinus, Infiltration | | |
Cellular, Histiocyte | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 3| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 3| 3| 3| 3| |
DAY ON TEST | 2| 2| 6| 3| 2| 2| 2| 0| 9| 3| 2| 2| 2| 2| 8| 2| 2| 2| 2| 6| 2| 8| 6| 3| 2| |
| 2| 2| 5| 8| 7| 2| 2| 5| 0| 8| 2| 2| 2| 5| 3| 5| 5| 5| 6| 8| 5| 8| 3| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Hemorrhage | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| 72 |
Hemorrhage | 2 | 3 1.7|
Hyperplasia, Lymphoid | 2 | 2 2.5|
Hyperplasia, Plasma Cell | 3 3 3 3 3 3 2 3 4| 20 3.0|
Sinus, Ectasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 |
Atrophy | 3| 2 3.5|
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Depletion Lymphoid | | 1 2.0|
Fibrosis, Focal | 3 | 1 3.0|
Fibrosis | 4 | 2 3.0|
Hematopoietic Cell Proliferation | 3 4 4 4 4 3 3 | 20 3.4|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + + M + M + + + + + + + M + + + + + + + + + + +| 67 |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 | 17 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Cyst Epithelial Inclusion | | 1 |
Epidermis, Hyperplasia, Basal Cell, | | |
Focal | | 1 1.0|
Hair Follicle, Hyperplasia, Basal | | |
Cell, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 2 |
Cranium, Fibrous Osteodystrophy | | 2 2.5|
Sternum, Fibrous Osteodystrophy | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Brain Stem, Compression | 2 | 1 2.0|
Brain Stem, Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 3| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 3| 3| 3| 3| |
DAY ON TEST | 2| 2| 6| 3| 2| 2| 2| 0| 9| 3| 2| 2| 2| 2| 8| 2| 2| 2| 2| 6| 2| 8| 6| 3| 2| |
| 2| 2| 5| 8| 7| 2| 2| 5| 0| 8| 2| 2| 2| 5| 3| 5| 5| 5| 6| 8| 5| 8| 3| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + M + + + + + + + + + + + + + + + + + + + + +| 74 |
Congestion | | 1 2.0|
Hemorrhage | | 2 2.5|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 36 1.0|
Metaplasia, Focal, Osseous | 1 | 1 1.0|
Metaplasia, Squamous | 2 | 1 2.0|
Mineralization | | 2 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 2 1 1 | 20 1.4|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 1 2 1 | 10 1.3|
Artery, Mineralization | | 1 3.0|
Interstitium, Inflammation | 1 4 1 1 | 4 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Fungus | | 1 3.0|
Hemorrhage | | 2 2.0|
Inflammation, Suppurative | 4 1| 6 2.3|
Olfactory Epithelium, Hyperplasia, | | |
Focal | 1| 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + M + + + + + + + + + + + + + + + + + + + + +| 74 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | +| 4 |
Anterior Chamber, Hemorrhage | | 2 3.5|
Cornea, Inflammation, Suppurative | 4| 3 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Pigmentation, Porphyrin | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 73 |
Ectasia | 2 | 4 1.8|
Hyperplasia, Focal, Glandular | | 3 2.3|
Hyperplasia, Focal, Squamous | 2 | 4 2.0|
Hypertrophy | 3 2 1 | 3 2.0|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Karyomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 61 1.0|
Nephropathy | 4 4 4 3 2 4 3 2 3 4 2 2 2 2 3 2 2 2 1 3 3 3 4 3| 72 2.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 3| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 3| 3| 3| 3| |
DAY ON TEST | 2| 2| 6| 3| 2| 2| 2| 0| 9| 3| 2| 2| 2| 2| 8| 2| 2| 2| 2| 6| 2| 8| 6| 3| 2| |
| 2| 2| 5| 8| 7| 2| 2| 5| 0| 8| 2| 2| 2| 5| 3| 5| 5| 5| 6| 8| 5| 8| 3| 8| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Dilatation | 3 | 2 3.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 2| 1| 4| 3| 3| 2| 2| 4| 4| 3| 3| 2|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 5| 2| 4| 2| 4| 3| 8| 6| 2| 0| 4| 4| 6|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 9| 2| 1| 1| 8| 0| 5| 1| 6| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.015 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 |
Congestion | 2 |
Cyst | |
Degeneration, Cystic | 2 |
Eosinophilic Focus | 2 2 2 1 2 3 2 2 2 |
Fatty Change, Multifocal | 1 |
Hematocyst | X |
Hematopoietic Cell Proliferation | 1 1 |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Re Cell | 2 |
Inflammation, Granulomatous, | |
Multifocal | 2 1 1 1 |
Inflammation, Multifocal, Suppurative| 1 |
Mixed Cell Focus | 1 2 3 3 3 3 |
Necrosis, Coagulative, Focal | |
Necrosis, Focal | |
Bile Duct, Cyst | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Pharynx | + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 |
Erosion, Multifocal | |
__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 2| 1| 4| 3| 3| 2| 2| 4| 4| 3| 3| 2|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 5| 2| 4| 2| 4| 3| 8| 6| 2| 0| 4| 4| 6|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 9| 2| 1| 1| 8| 0| 5| 1| 6| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.015 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperkeratosis, Focal | 2 |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Mitral Valve, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Focal | |
Vacuolization Cytoplasmic, Focal | 2 1 |
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Duct, Ectasia | 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Thrombosis | |
Endometrium, Hyperplasia, Papillary | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 2| 1| 4| 3| 3| 2| 2| 4| 4| 3| 3| 2|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 5| 2| 4| 2| 4| 3| 8| 6| 2| 0| 4| 4| 6|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 9| 2| 1| 1| 8| 0| 5| 1| 6| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.015 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Iliac, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 3 3 4 2 3|
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + M + + M + + + + M + + + +|
Cyst | |
Depletion Lymphoid | |
Hemorrhage | 3 |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + M + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Cranium, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Cerebellum, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Congestion | 4 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 2| 1| 4| 3| 3| 2| 2| 4| 4| 3| 3| 2|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 5| 2| 4| 2| 4| 3| 8| 6| 2| 0| 4| 4| 6|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 9| 2| 1| 1| 8| 0| 5| 1| 6| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.015 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Edema | |
Foreign Body | |
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 |
Pigmentation | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 |
Bronchiole, Inflammation, Suppurative| |
Interstitium, Inflammation | 1 1|
Peribronchiolar, Alveolus, | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | 2 |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Ulcer | |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Suppurative | |
__________________________________________________________________________|
Harderian Gland | |
Pigmentation, Porphyrin | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal, Squamous | 3 |
Hypertrophy | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Karyomegaly | 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 2 3 3 2 3 2 2 2 1 2 2 4 3 1|
Medulla, Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Hyperplasia, Papillary | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 4| 4| 3| 3| 3| 4| 3| 3| 3| 2| 4| 4| 4| 4| 2| 4| 4| 3| 3| 2|
DAY ON TEST | 9| 4| 3| 3| 9| 2| 2| 9| 1| 1| 2| 9| 7| 3| 9| 2| 2| 0| 0| 9| 2| 0| 7| 7| 6|
| 1| 1| 8| 6| 6| 1| 1| 1| 5| 5| 1| 0| 7| 8| 6| 2| 2| 5| 6| 5| 6| 6| 8| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
0.015 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Congestion | |
Cyst | X |
Degeneration, Cystic | 2 1 2 2 2 |
Eosinophilic Focus | 2 2 3 2 2 2 2 2 2 2 2 2 2 3 2 |
Fatty Change, Multifocal | |
Hematocyst | |
Hematopoietic Cell Proliferation | 1 1 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Re Cell | |
Inflammation, Granulomatous, | |
Multifocal | 1 1 |
Inflammation, Multifocal, Suppurative| |
Mixed Cell Focus | 2 3 3 3 3 2 3 2 3 1 1 3 3 3 2 3 2|
Necrosis, Coagulative, Focal | |
Necrosis, Focal | 4 |
Bile Duct, Cyst | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Pharynx | + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 1 1 |
Erosion, Multifocal | 2 |
__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 4| 4| 3| 3| 3| 4| 3| 3| 3| 2| 4| 4| 4| 4| 2| 4| 4| 3| 3| 2|
DAY ON TEST | 9| 4| 3| 3| 9| 2| 2| 9| 1| 1| 2| 9| 7| 3| 9| 2| 2| 0| 0| 9| 2| 0| 7| 7| 6|
| 1| 1| 8| 6| 6| 1| 1| 1| 5| 5| 1| 0| 7| 8| 6| 2| 2| 5| 6| 5| 6| 6| 8| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
0.015 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperkeratosis, Focal | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Mitral Valve, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 |
Hyperplasia, Focal | |
Vacuolization Cytoplasmic, Focal | 2 2 |
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X X X X|
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 3 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 4 |
Endometrium, Hyperplasia, Papillary | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 4| 4| 3| 3| 3| 4| 3| 3| 3| 2| 4| 4| 4| 4| 2| 4| 4| 3| 3| 2|
DAY ON TEST | 9| 4| 3| 3| 9| 2| 2| 9| 1| 1| 2| 9| 7| 3| 9| 2| 2| 0| 0| 9| 2| 0| 7| 7| 6|
| 1| 1| 8| 6| 6| 1| 1| 1| 5| 5| 1| 0| 7| 8| 6| 2| 2| 5| 6| 5| 6| 6| 8| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
0.015 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + M + + + + + +|
Atrophy | 3 2 3 |
Hemorrhage | 3 2 3 |
Hyperplasia | 2 3 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Iliac, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Hemorrhage | 2 3 |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 3 3 3 3 3 3 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 3 4 3 3 4 |
Red Pulp, Atrophy | 3 3 |
__________________________________________________________________________|
Thymus | + M + + + M + M + + + + + + + + + M + + M + I M +|
Cyst | X |
Depletion Lymphoid | 3 |
Hemorrhage | |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Cyst Epithelial Inclusion | X X X |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
Cranium, Fibrous Osteodystrophy | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 4| 4| 3| 3| 3| 4| 3| 3| 3| 2| 4| 4| 4| 4| 2| 4| 4| 3| 3| 2|
DAY ON TEST | 9| 4| 3| 3| 9| 2| 2| 9| 1| 1| 2| 9| 7| 3| 9| 2| 2| 0| 0| 9| 2| 0| 7| 7| 6|
| 1| 1| 8| 6| 6| 1| 1| 1| 5| 5| 1| 0| 7| 8| 6| 2| 2| 5| 6| 5| 6| 6| 8| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
0.015 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Edema | 2 |
Foreign Body | 1 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 2 1 1 1 1 1 1 1 1 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 1 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 1 1 1 1 |
Bronchiole, Inflammation, Suppurative| 2 |
Interstitium, Inflammation | |
Peribronchiolar, Alveolus, | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Hemorrhage | 2 |
Inflammation, Suppurative | 4 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Ulcer | 4 |
__________________________________________________________________________|
Eye | + + |
Cornea, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Harderian Gland | + |
Pigmentation, Porphyrin | 4 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Focal, Squamous | |
Hypertrophy | 1 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Karyomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 3 4 3 2 4 3 3 3 2 3 4 4 3 3 2 4 4 3 4 3 4 3 4 4 2|
Medulla, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Papillary | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 2| 4| 3| 3| 2| 2| 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| | |
DAY ON TEST | 9| 8| 6| 8| 8| 2| 9| 3| 5| 4| 2| 8| 8| 4| 3| 0| 0| 9| 8| 7| | |
| 1| 3| 4| 5| 5| 2| 1| 5| 1| 7| 2| 4| 3| 3| 5| 5| 5| 1| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.015 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 60 |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 60 |
Parasite Metazoan | 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 60 |
Parasite Metazoan | 2 2 | 5 1.6|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 60 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | 2 2 | 3 2.0|
Congestion | | 1 2.0|
Cyst | X | 2 |
Degeneration, Cystic | 2 2 2 2 1 | 11 1.8|
Eosinophilic Focus | 2 2 2 1 3 3 2 2 2 3 2 3 3 2 | 38 2.2|
Fatty Change, Multifocal | 1 | 2 1.0|
Hematocyst | | 1 |
Hematopoietic Cell Proliferation | 1 2 1 | 8 1.1|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | X | 3 |
Hyperplasia, Re Cell | | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 1 1 1 1 | 10 1.1|
Inflammation, Multifocal, Suppurative| | 1 1.0|
Mixed Cell Focus | 2 2 2 2 2 3 2 2 3 | 32 2.4|
Necrosis, Coagulative, Focal | 2 | 1 2.0|
Necrosis, Focal | | 1 4.0|
Bile Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 60 |
Acinus, Atrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 2| 4| 3| 3| 2| 2| 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| | |
DAY ON TEST | 9| 8| 6| 8| 8| 2| 9| 3| 5| 4| 2| 8| 8| 4| 3| 0| 0| 9| 8| 7| | |
| 1| 3| 4| 5| 5| 2| 1| 5| 1| 7| 2| 4| 3| 3| 5| 5| 5| 1| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.015 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 1 1 | 11 1.1|
Erosion, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + | 10 |
Hyperkeratosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Peridontal Tissue, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 60 |
Cardiomyopathy | 1 | 3 1.0|
Mitral Valve, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 60 |
Angiectasis | 3 2 2 2 | 8 2.1|
Hyperplasia, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 | 5 1.6|
Vacuolization Cytoplasmic, Multifocal| 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 58 |
Hyperplasia | 3 | 3 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Cyst | X X X | 8 |
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
Pars Distalis, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Ultimobranchial Cyst | X X X | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 2| 4| 3| 3| 2| 2| 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| | |
DAY ON TEST | 9| 8| 6| 8| 8| 2| 9| 3| 5| 4| 2| 8| 8| 4| 3| 0| 0| 9| 8| 7| | |
| 1| 3| 4| 5| 5| 2| 1| 5| 1| 7| 2| 4| 3| 3| 5| 5| 5| 1| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.015 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | 59 |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Duct, Ectasia | 3 3 | 5 2.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 60 |
Periovarian Tissue, Cyst | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 60 |
Thrombosis | | 1 4.0|
Endometrium, Hyperplasia, Papillary | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 59 |
Atrophy | 2 | 4 2.5|
Hemorrhage | 2 | 4 2.5|
Hyperplasia | 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 60 |
Hemorrhage | | 1 2.0|
Iliac, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Hemorrhage | 3 | 3 2.7|
Mediastinal, Hyperplasia, Plasma Cell| | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 60 |
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
Hyperplasia, Plasma Cell | 3 3 2 3 3 | 18 2.9|
Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 3 3 4 2 4 | 14 3.4|
Red Pulp, Atrophy | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + M + + + M M M + | 45 |
Cyst | | 1 |
Depletion Lymphoid | | 1 3.0|
Hemorrhage | | 1 3.0|
Epithelial Cell, Hyperplasia | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 2| 4| 3| 3| 2| 2| 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| | |
DAY ON TEST | 9| 8| 6| 8| 8| 2| 9| 3| 5| 4| 2| 8| 8| 4| 3| 0| 0| 9| 8| 7| | |
| 1| 3| 4| 5| 5| 2| 1| 5| 1| 7| 2| 4| 3| 3| 5| 5| 5| 1| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.015 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Acanthosis | | 1 3.0|
Cyst Epithelial Inclusion | | 3 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 1 |
Cranium, Fibrous Osteodystrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 60 |
Cerebellum, Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 60 |
Congestion | | 2 3.5|
Edema | | 1 2.0|
Foreign Body | | 1 1.0|
Hemorrhage | | 2 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 | 29 1.0|
Pigmentation | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 2 | 7 1.6|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 2 | 6 1.3|
Bronchiole, Inflammation, Suppurative| | 1 2.0|
Interstitium, Inflammation | | 2 1.0|
Peribronchiolar, Alveolus, | | |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 60 |
Foreign Body | | 1 3.0|
Hemorrhage | 1 2 | 4 1.8|
Inflammation, Suppurative | 2 | 5 2.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Eye | + + | 4 |
Cornea, Inflammation, Suppurative | 2 4 | 3 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 2| 4| 3| 3| 2| 2| 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| | |
DAY ON TEST | 9| 8| 6| 8| 8| 2| 9| 3| 5| 4| 2| 8| 8| 4| 3| 0| 0| 9| 8| 7| | |
| 1| 3| 4| 5| 5| 2| 1| 5| 1| 7| 2| 4| 3| 3| 5| 5| 5| 1| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.015 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Pigmentation, Porphyrin | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Cyst | | 1 |
Hyperplasia, Focal, Squamous | 2 | 2 2.5|
Hypertrophy | | 3 1.7|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 60 |
Hemorrhage | | 1 2.0|
Karyomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 56 1.0|
Nephropathy | 4 4 3 2 2 4 3 3 2 2 3 2 4 2 4 2 3 2 4 3 | 59 2.9|
Medulla, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Papillary | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Basophilic Focus | |
Fatty Change, Focal | |
Hemorrhage, Focal | |
Hepatodiaphragmatic Nodule | X |
Infarct | 4 |
Inflammation, Acute, Focal | 1 1|
Inflammation, Acute, Multifocal | 1 |
Inflammation, Granulomatous, | |
Multifocal | |
Necrosis, Coagulative, Multifocal | 1 |
Necrosis, Focal | 4 |
Bile Duct, Hyperplasia | 2 1 2 2 2 1 2 1 2 2|
Caudate Lobe, Infarct | |
Serosa, Cyst | X |
Serosa, Fibrosis, Focal | 3 |
Serosa, Pigmentation, Focal, | |
Hemosiderin | 3 |
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | 4 |
Fat, Necrosis, Focal | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 1 |
Myocardium, Necrosis, Focal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic Active | 2 1 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + +|
Hypospermia | 2 2 |
Mineralization | |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Bronchial, Hemorrhage | |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 |
Pancreatic, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Fibrosis | |
Capsule, Fibrosis, Focal | 2 |
__________________________________________________________________________|
Thymus | M M + + + + M + + M + + M + +|
Hyperplasia, Lymphoid | 2 |
Epithelial Cell, Hyperplasia | 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + + M + M M + M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 |
Inflammation, Focal, Granulomatous | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Foreign Body | 1 1 |
Hemorrhage | 2 2 2 |
Inflammation, Suppurative | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy | 2 1 2 2 2 2 1 2 1 2 2 2 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Lumen, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Fatty Change, Focal | 1 |
Hemorrhage, Focal | 2 |
Hepatodiaphragmatic Nodule | X |
Infarct | |
Inflammation, Acute, Focal | |
Inflammation, Acute, Multifocal | |
Inflammation, Granulomatous, | |
Multifocal | 1 |
Necrosis, Coagulative, Multifocal | |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 2 1 2 2 2 1 1 2 2|
Caudate Lobe, Infarct | |
Serosa, Cyst | |
Serosa, Fibrosis, Focal | |
Serosa, Pigmentation, Focal, | |
Hemosiderin | |
__________________________________________________________________________|
Mesentery | |
Hemorrhage | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 2 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 2 2 2 2 1 2 2 2 |
Myocardium, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X X |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 1 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 1 3 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | 4 4 3 3 |
Mineralization | 2 2 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hemorrhage | 3 |
Mediastinal, Hemorrhage | 2 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 |
Pancreatic, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 3 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Re Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Capsule, Fibrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M M + M + + + + + +|
Hyperplasia, Lymphoid | |
Epithelial Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + M M M + + + + + M + + + + M M + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Inflammation, Focal, Granulomatous | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | 2 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Nephropathy | 2 1 2 1 2 2 1 2 1 2 2 1 2 2 1 2 1 2 1 2 2 2 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 60 |
Parasite Metazoan | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 60 |
Parasite Metazoan | 1 2 2 | 8 1.6|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 60 |
Parasite Metazoan | 3 2 2 2 2 2 | 8 2.1|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 60 |
Basophilic Focus | 2 | 1 2.0|
Fatty Change, Focal | | 1 1.0|
Hemorrhage, Focal | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 3 |
Infarct | | 1 4.0|
Inflammation, Acute, Focal | 1 | 3 1.0|
Inflammation, Acute, Multifocal | | 1 1.0|
Inflammation, Granulomatous, | | |
Multifocal | | 1 1.0|
Necrosis, Coagulative, Multifocal | | 1 1.0|
Necrosis, Focal | 4 | 2 4.0|
Bile Duct, Hyperplasia | 2 2 2 1 2 2 2 1 1 | 39 1.7|
Caudate Lobe, Infarct | 4 | 1 4.0|
Serosa, Cyst | | 1 |
Serosa, Fibrosis, Focal | | 1 3.0|
Serosa, Pigmentation, Focal, | | |
Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Hemorrhage | | 1 4.0|
Fat, Necrosis, Focal | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic | 2 | 1 2.0|
Acinus, Atrophy | 2 2 2 | 9 1.9|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 1 1 1 1 1 1 1 1 1 | 22 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 60 |
Cardiomyopathy | 1 1 1 2 | 17 1.7|
Myocardium, Necrosis, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Cyst | X | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Ultimobranchial Cyst | | 3 |
C-Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 | 7 1.9|
Duct, Ectasia | 3 | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Chronic Active | 2 3 2 2 2 2 2 2 2 2 2 1 2 2 | 35 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 60 |
Hypospermia | 1 2 1 | 9 2.4|
Mineralization | 1 | 3 1.7|
Interstitial Cell, Hyperplasia | 2 2 2 1 2 2 2 2 2 2 1 2 2 2 2 2 2 | 44 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 60 |
Bronchial, Hemorrhage | | 1 3.0|
Mediastinal, Hemorrhage | 2 | 5 2.2|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 2 2.0|
Pancreatic, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Plasma Cell | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 60 |
Hemorrhage | | 1 3.0|
Hyperplasia, Re Cell | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 60 |
Fibrosis | 2 | 1 2.0|
Capsule, Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + M + + + + M + + + I I + + + + + + | 47 |
Hyperplasia, Lymphoid | | 1 2.0|
Epithelial Cell, Hyperplasia | 2 2 2 | 9 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + M + + + + + + + + M + M + + M + | 41 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 | 9 1.0|
Inflammation, Focal, Granulomatous | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 3 | 5 2.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 60 |
Foreign Body | | 2 1.0|
Hemorrhage | | 5 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 3.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + M + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 60 |
Hydronephrosis | | 1 2.0|
Nephropathy | 2 2 2 1 2 2 2 2 2 2 1 2 1 2 1 2 2 2 1 1 | 60 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Lumen, Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 1| 1| 1| 5| 1| 1| 1| 1| 9| 1| 1| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.003 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 1 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 1 1 2 2 2 1 1 2 1 1 2 1 1 1 2 1 2|
Degeneration, Cystic | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Fatty Change, Focal | |
Fatty Change, Multifocal | 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 1|
Mixed Cell Focus | 2 2 2 2 2 1 2 2 2 1 2 2 2 1 2 2 1 1 1 2 1 |
Necrosis, Focal | 4 4 |
Bile Duct, Hyperplasia | 2 1 |
Centrilobular, Necrosis, Coagulative | 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation, Chronic | 4 |
Fat, Necrosis, Focal | 2 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
Acinus, Atrophy | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Multifocal | 2 |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 1 2 1 2 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 1| 1| 1| 5| 1| 1| 1| 1| 9| 1| 1| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.003 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic Active | 2 3 2 3 2 2 2 3 2 2 2 3 1 2 2|
Inflammation, Suppurative | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | 2 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 2 3 2 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 3 3 3|
Sinus, Ectasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + M + + + M + + + + + + M|
Epithelial Cell, Hyperplasia | 1 2 2 1 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 1| 1| 1| 5| 1| 1| 1| 1| 9| 1| 1| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.003 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 1 2 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | |
Hemorrhage | 2 2 2 |
Inflammation, Acute | 1 |
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | 2 |
Nephropathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 5| 6| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.003 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 45 |
Parasite Metazoan | 2 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 45 |
Parasite Metazoan | 2 1 2 | 6 1.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 44 |
Parasite Metazoan | 1 1 2 2 | 8 1.5|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 45 |
Basophilic Focus | 2 1 1 1 1 1 2 1 2 2 2 1 | 31 1.5|
Degeneration, Cystic | 1 1 1 2 1 1 1 1 1 | 24 1.1|
Fatty Change, Focal | 1 | 1 1.0|
Fatty Change, Multifocal | | 1 1.0|
Hematopoietic Cell Proliferation | 2 1 | 2 1.5|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation, Granulomatous, | | |
Multifocal | 1 | 5 1.0|
Mixed Cell Focus | 2 1 1 2 1 1 2 2 1 2 2 2 2 2 1 2 | 37 1.6|
Necrosis, Focal | 4 4 | 4 4.0|
Bile Duct, Hyperplasia | 1 | 3 1.3|
Centrilobular, Necrosis, Coagulative | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Artery, Inflammation, Chronic | | 1 4.0|
Fat, Necrosis, Focal | 3 4 | 5 3.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 44 |
Acinus, Atrophy | 1 2 | 4 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 45 |
Ulcer, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Dysplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 5| 6| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.003 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 45 |
Cardiomyopathy | 1 2 1 1 1 2 | 19 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 45 |
Cyst | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 44 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 45 |
Inflammation, Chronic Active | 2 | 2 2.0|
Duct, Ectasia | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 45 |
Hyperplasia, Focal | 2 2 | 2 2.0|
Inflammation, Chronic Active | 2 2 2 3 2 3 2 2 2 2 2 2 2 | 28 2.2|
Inflammation, Suppurative | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 44 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 45 |
Hypospermia | 3 1 | 3 2.0|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 35 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + M + + + + + | 44 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 45 |
Mediastinal, Hemorrhage | 2 | 6 2.3|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 5| 6| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.003 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Plasma Cell | 2 | 5 2.6|
Sinus, Ectasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 45 |
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + + + | 40 |
Epithelial Cell, Hyperplasia | 2 2 2 2 | 9 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + | 38 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 44 |
Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 45 |
Infiltration Cellular, Histiocyte | | 3 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 3 3 2 1 | 11 1.8|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 45 |
Foreign Body | 2 | 2 2.0|
Fungus | 3 | 1 3.0|
Hemorrhage | 2 2 | 5 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Suppurative | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 5| 6| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.003 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 45 |
Cyst | | 1 |
Hydronephrosis | | 1 2.0|
Nephropathy | 2 2 2 2 2 2 2 1 2 2 2 2 2 1 1 2 1 2 2 2 | 43 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 45 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2|
DAY ON TEST | 1| 1| 1| 1| 4| 1| 1| 1| 0| 8| 2| 2| 1| 1| 9| 1| 1| 1| 1| 2| 1| 1| 2| 2| 8|
| 9| 9| 9| 9| 3| 9| 9| 9| 4| 5| 6| 6| 9| 9| 3| 9| 9| 9| 9| 5| 9| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 4 4 4 2 2 2 2 2 3 2 2 2 2 2 2|
Congestion | |
Degeneration, Cystic | 2 2 2 2 2 2 2 3 3 2 3 2 3 2 3 2 2 3 3 2 2 2 3 |
Eosinophilic Focus | 3 2 2 2 3 2 2 3 2 2 3 3 3 2 2 3 2 2|
Fatty Change, Diffuse | |
Hematopoietic Cell Proliferation | 1 1 1 1 1 2 1|
Hepatodiaphragmatic Nodule | X X |
Infarct | 4 4|
Inflammation, Granulomatous, | |
Multifocal | |
Mixed Cell Focus | 3 3 3 2 3 2 2 2 2 2 3 3 3 2 2 3 2 3 1|
Necrosis, Focal | 4 4 4 |
Necrosis, Multifocal | |
Bile Duct, Hyperplasia | |
Biliary Tract, Inflammation, Subacute| |
Caudate Lobe, Infarct | |
Centrilobular, Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 2 1 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2|
DAY ON TEST | 1| 1| 1| 1| 4| 1| 1| 1| 0| 8| 2| 2| 1| 1| 9| 1| 1| 1| 1| 2| 1| 1| 2| 2| 8|
| 9| 9| 9| 9| 3| 9| 9| 9| 4| 5| 6| 6| 9| 9| 3| 9| 9| 9| 9| 5| 9| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 |
Ectopic Tissue | X |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 1 1 2 2|
Atrium, Dilatation | |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 1 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2|
Arteriole, Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Focal | 2 |
Inflammation, Chronic Active | 3 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2|
DAY ON TEST | 1| 1| 1| 1| 4| 1| 1| 1| 0| 8| 2| 2| 1| 1| 9| 1| 1| 1| 1| 2| 1| 1| 2| 2| 8|
| 9| 9| 9| 9| 3| 9| 9| 9| 4| 5| 6| 6| 9| 9| 3| 9| 9| 9| 9| 5| 9| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Ectasia | 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | 3 3 2 2 2 2 2 2 2 2 2 1|
Inflammation, Subacute | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hypospermia | 3 2 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Hyperplasia, Plasma | |
Cell | |
Mediastinal, Hemorrhage | 2 3 2 2 |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Hyperplasia, Re Cell | |
Mediastinal, Sinus, Infiltration | |
Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Plasma Cell | 2 3 2 3 |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 3 4 2 4 3|
Thrombosis | |
__________________________________________________________________________|
Thymus | M M + + + + + + + + M M M + + + + + + + + M + M +|
Hemorrhage | |
Epithelial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M + M + + + + + + + + + + M M + + + + M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2|
DAY ON TEST | 1| 1| 1| 1| 4| 1| 1| 1| 0| 8| 2| 2| 1| 1| 9| 1| 1| 1| 1| 2| 1| 1| 2| 2| 8|
| 9| 9| 9| 9| 3| 9| 9| 9| 4| 5| 6| 6| 9| 9| 3| 9| 9| 9| 9| 5| 9| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | 1 1 |
Hair Follicle, Hyperplasia, Basal | |
Cell, Multifocal | |
Sebaceous Gland, Hyperplasia, Focal | 1 1 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Hemorrhage, Multifocal | |
Cerebrum, Necrosis, Focal | |
Thalamus, Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Embolus | 2 |
Foreign Body | |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 3 2 1 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 2 2 |
Interstitium, Inflammation | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 3 |
Hemorrhage | 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Ectasia | |
Hyperplasia, Focal, Glandular | |
Inflammation, Acute | |
Inflammation, Granulomatous | |
Bilateral, Hyperplasia, Focal, | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2|
DAY ON TEST | 1| 1| 1| 1| 4| 1| 1| 1| 0| 8| 2| 2| 1| 1| 9| 1| 1| 1| 1| 2| 1| 1| 2| 2| 8|
| 9| 9| 9| 9| 3| 9| 9| 9| 4| 5| 6| 6| 9| 9| 3| 9| 9| 9| 9| 5| 9| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Glandular | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration, Hyaline | |
Hydronephrosis | |
Nephropathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 3| 3| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3|
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 9| 7| 8| 2| 2| 2| 2| 0| 2| 2| 0| 2| 4| 2| 2| 2| 2| 5|
| 0| 0| 0| 0| 2| 0| 0| 1| 9| 5| 0| 0| 0| 0| 6| 0| 0| 6| 0| 1| 0| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Congestion | 3 |
Degeneration, Cystic | 2 2 2 2 2 2 2 2 1 2 2 3 2 2 2 3 2 2 2 2 2 2 |
Eosinophilic Focus | 2 3 2 3 3 2 2 3 2 2 2 3 2 2 2 2 2 2 |
Fatty Change, Diffuse | |
Hematopoietic Cell Proliferation | 1 2 1 1 1 1 1 2 2 1|
Hepatodiaphragmatic Nodule | |
Infarct | |
Inflammation, Granulomatous, | |
Multifocal | 1 |
Mixed Cell Focus | 3 3 3 2 3 2 3 3 2 2 3 2 2 2 3 3 2 2 |
Necrosis, Focal | 4 4 4 3 |
Necrosis, Multifocal | 2|
Bile Duct, Hyperplasia | |
Biliary Tract, Inflammation, Subacute| |
Caudate Lobe, Infarct | 4 |
Centrilobular, Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 1 2 1 |
__________________________________________________________________________|
Pharynx | + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 3| 3| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3|
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 9| 7| 8| 2| 2| 2| 2| 0| 2| 2| 0| 2| 4| 2| 2| 2| 2| 5|
| 0| 0| 0| 0| 2| 0| 0| 1| 9| 5| 0| 0| 0| 0| 6| 0| 0| 6| 0| 1| 0| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
Ectopic Tissue | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 2 1 1 2 1 1 2 |
Atrium, Dilatation | 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | |
Vacuolization Cytoplasmic, Focal | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Arteriole, Inflammation, Chronic | 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Focal | |
Inflammation, Chronic Active | 2 2 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 3| 3| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3|
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 9| 7| 8| 2| 2| 2| 2| 0| 2| 2| 0| 2| 4| 2| 2| 2| 2| 5|
| 0| 0| 0| 0| 2| 0| 0| 1| 9| 5| 0| 0| 0| 0| 6| 0| 0| 6| 0| 1| 0| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Ectasia | 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 3 2 3 2 2 |
Inflammation, Subacute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1|
Hypospermia | 2 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Hyperplasia, Plasma | |
Cell | 3 |
Mediastinal, Hemorrhage | 2 2 3 2 |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Hyperplasia, Re Cell | 3 |
Mediastinal, Sinus, Infiltration | |
Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Plasma Cell | 2 3 3 2 3 2 |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 4 3 4 4 3 4 3 4 3|
Thrombosis | |
__________________________________________________________________________|
Thymus | + + M + + M + M M + + + + + + + + M + + M + + M +|
Hemorrhage | |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + M + + + M + M + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 3| 3| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3|
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 9| 7| 8| 2| 2| 2| 2| 0| 2| 2| 0| 2| 4| 2| 2| 2| 2| 5|
| 0| 0| 0| 0| 2| 0| 0| 1| 9| 5| 0| 0| 0| 0| 6| 0| 0| 6| 0| 1| 0| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | 4 |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | |
Hair Follicle, Hyperplasia, Basal | |
Cell, Multifocal | |
Sebaceous Gland, Hyperplasia, Focal | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Hemorrhage, Multifocal | 3|
Cerebrum, Necrosis, Focal | 2|
Thalamus, Cyst | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Embolus | |
Foreign Body | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 2 2 2 2 1 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 2 2 3 |
Interstitium, Inflammation | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Fungus | |
Hemorrhage | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Ectasia | |
Hyperplasia, Focal, Glandular | 1 |
Inflammation, Acute | 1 |
Inflammation, Granulomatous | |
Bilateral, Hyperplasia, Focal, | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 3| 3| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3|
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 9| 7| 8| 2| 2| 2| 2| 0| 2| 2| 0| 2| 4| 2| 2| 2| 2| 5|
| 0| 0| 0| 0| 2| 0| 0| 1| 9| 5| 0| 0| 0| 0| 6| 0| 0| 6| 0| 1| 0| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.007 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Glandular | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration, Hyaline | 2|
Hydronephrosis | |
Nephropathy | 2 2 1 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 3| 3| 2| 0| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 4| 4| 4| 4| 2| |
DAY ON TEST | 2| 8| 7| 2| 1| 2| 2| 0| 2| 0| 2| 2| 2| 0| 8| 2| 2| 2| 7| 9| 2| 2| 2| 0| 1| |
| 0| 4| 8| 9| 2| 1| 1| 5| 1| 7| 1| 1| 1| 5| 4| 1| 1| 6| 9| 5| 1| 1| 1| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hemorrhage | | 1 2.0|
Parasite Metazoan | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Parasite Metazoan | 1 1 1 1 | 8 1.4|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Parasite Metazoan | 1 2 | 5 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Basophilic Focus | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 3 3 2 2 2 2| 54 2.1|
Congestion | | 1 3.0|
Degeneration, Cystic | 2 3 2 2 2 2 2 2 2 2 2 2 3 2 3 3 2 2 2 2 3 2 | 67 2.2|
Eosinophilic Focus | 2 3 2 2 2 2 2 3 3 3 2 3 2 2 2 3 2 2 2 2 2| 57 2.3|
Fatty Change, Diffuse | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 2 1 | 27 1.2|
Hepatodiaphragmatic Nodule | X | 3 |
Infarct | 4| 3 4.0|
Inflammation, Granulomatous, | | |
Multifocal | 1 1 | 3 1.0|
Mixed Cell Focus | 2 3 2 2 2 2 1 3 3 3 3 2 2 2 3 3 2 | 54 2.4|
Necrosis, Focal | 4 4 | 9 3.9|
Necrosis, Multifocal | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 | 2 2.0|
Biliary Tract, Inflammation, Subacute| 2 | 1 2.0|
Caudate Lobe, Infarct | | 1 4.0|
Centrilobular, Necrosis, Coagulative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Necrosis, Focal | 4 3 | 6 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Inflammation, Chronic | 2 | 1 2.0|
Acinus, Atrophy | 2 2 | 7 1.6|
__________________________________________________________________________|____________|
Pharynx | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 3| 3| 2| 0| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 4| 4| 4| 4| 2| |
DAY ON TEST | 2| 8| 7| 2| 1| 2| 2| 0| 2| 0| 2| 2| 2| 0| 8| 2| 2| 2| 7| 9| 2| 2| 2| 0| 1| |
| 0| 4| 8| 9| 2| 1| 1| 5| 1| 7| 1| 1| 1| 5| 4| 1| 1| 6| 9| 5| 1| 1| 1| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Erosion, Focal | | 1 2.0|
Hyperplasia | | 1 3.0|
Ulcer | 3 | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Degeneration, Cystic | 1 | 4 1.0|
Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Cardiomyopathy | 2 2 2 1 2 1 1 1 2 1 2 2 2 2 2| 35 1.5|
Atrium, Dilatation | | 1 3.0|
Atrium, Thrombosis | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 5 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + M + + + + M + + + + + +| 71 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Angiectasis | | 1 2.0|
Cyst | X | 1 |
Pars Distalis, Hyperplasia, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | | 1 2.0|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 3| 3| 2| 0| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 4| 4| 4| 4| 2| |
DAY ON TEST | 2| 8| 7| 2| 1| 2| 2| 0| 2| 0| 2| 2| 2| 0| 8| 2| 2| 2| 7| 9| 2| 2| 2| 0| 1| |
| 0| 4| 8| 9| 2| 1| 1| 5| 1| 7| 1| 1| 1| 5| 4| 1| 1| 6| 9| 5| 1| 1| 1| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Inflammation, Chronic | | 1 2.0|
Arteriole, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Atrophy | 3 | 1 3.0|
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic Active | 2 2 2 | 9 2.0|
Duct, Ectasia | 2 | 7 2.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hyperplasia, Multifocal | | 1 1.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic Active | 2 3 3 2 2 2 1 | 32 2.1|
Inflammation, Subacute | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Atrophy | 3 3 | 8 2.6|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hemorrhage | | 1 1.0|
Hypospermia | 1 3 | 5 2.2|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 | 28 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Deep Cervical, Hyperplasia, Plasma | | |
Cell | | 1 3.0|
Mediastinal, Hemorrhage | 2 | 9 2.2|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0|
Mediastinal, Hyperplasia, Re Cell | | 1 3.0|
Mediastinal, Sinus, Infiltration | | |
Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Hemorrhage | 2 | 2 2.0|
Hyperplasia, Plasma Cell | 2 2 2 3 3 3 3 3 | 18 2.6|
Sinus, Ectasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 3| 3| 2| 0| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 4| 4| 4| 4| 2| |
DAY ON TEST | 2| 8| 7| 2| 1| 2| 2| 0| 2| 0| 2| 2| 2| 0| 8| 2| 2| 2| 7| 9| 2| 2| 2| 0| 1| |
| 0| 4| 8| 9| 2| 1| 1| 5| 1| 7| 1| 1| 1| 5| 4| 1| 1| 6| 9| 5| 1| 1| 1| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | 3 | 2 2.5|
Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Congestion | | 1 3.0|
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 2 4 4 3 2 | 22 3.3|
Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + M M M + M + M + + M + M + + M M M + +| 50 |
Hemorrhage | 2 | 1 2.0|
Epithelial Cell, Hyperplasia | 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + + + + + + + + M + + + + + + +| 61 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Acanthosis | | 1 3.0|
Cyst Epithelial Inclusion | X | 1 |
Inflammation, Chronic Active | | 1 4.0|
Hair Follicle, Hyperplasia, Basal | | |
Cell, Focal | 1 1 | 4 1.0|
Hair Follicle, Hyperplasia, Basal | | |
Cell, Multifocal | 1 | 1 1.0|
Sebaceous Gland, Hyperplasia, Focal | | 6 2.2|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Cerebrum, Hemorrhage, Multifocal | | 1 3.0|
Cerebrum, Necrosis, Focal | | 1 2.0|
Thalamus, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Congestion | 3 | 2 3.0|
Embolus | | 1 2.0|
Foreign Body | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 1 1 1 | 13 1.0|
Alveolar Epithelium, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 4| 3| 3| 2| 0| 4| 4| 4| 4| 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 4| 4| 4| 4| 2| |
DAY ON TEST | 2| 8| 7| 2| 1| 2| 2| 0| 2| 0| 2| 2| 2| 0| 8| 2| 2| 2| 7| 9| 2| 2| 2| 0| 1| |
| 0| 4| 8| 9| 2| 1| 1| 5| 1| 7| 1| 1| 1| 5| 4| 1| 1| 6| 9| 5| 1| 1| 1| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
0.007 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Focal | 1 1 3 1 | 19 1.7|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 2 3 3 1 2 | 12 2.2|
Interstitium, Inflammation | 3 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Foreign Body | | 1 1.0|
Fungus | | 1 3.0|
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Cyst | X | 1 |
Ectasia | 3 | 1 3.0|
Hyperplasia, Focal, Glandular | | 1 1.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Granulomatous | 3 | 1 3.0|
Bilateral, Hyperplasia, Focal, | | |
Glandular | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Cyst | X | 1 |
Degeneration, Hyaline | | 1 2.0|
Hydronephrosis | 2 | 1 2.0|
Nephropathy | 2 2 2 1 2 2 2 2 1 3 2 2 2 2 2 2 2 2 2 2 3 2 2 1| 74 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 2|
DAY ON TEST | 7| 7| 6| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 3| 1| 0| 8| 5| 3| 1| 6| 5|
| 5| 5| 8| 9| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 4| 8| 8| 2| 9| 0| 2| 3| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.015 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + M + + +|
Parasite Metazoan | 2 1 |
Artery, Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + M + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 2 1 1 2 X 2|
Degeneration, Cystic | 3 2 2 2 3 2 3 3 2 |
Eosinophilic Focus | 3 2 2 2 3 2 3 2 3 2 2 2 2|
Fatty Change, Focal | |
Fatty Change, Multifocal | |
Hematocyst | |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Acute, Multifocal | 2 |
Inflammation, Granulomatous, | |
Multifocal | 1 |
Mixed Cell Focus | 1 2 2 2 2 2 2 2|
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative, Multifocal | 3 |
Necrosis, Focal | |
Necrosis, Multifocal | |
Bile Duct, Hyperplasia, Focal, | |
Adenomatous | |
Bile Duct, Hyperplasia | |
Caudate Lobe, Regeneration | 3 |
Caudate Lobe, Periportal, Fibrosis | 3 |
Centrilobular, Necrosis, Coagulative | 3 2 3 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Granulomatous | |
Artery, Mineralization | 3 3 3 |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 2|
DAY ON TEST | 7| 7| 6| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 3| 1| 0| 8| 5| 3| 1| 6| 5|
| 5| 5| 8| 9| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 4| 8| 8| 2| 9| 0| 2| 3| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.015 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Artery, Mineralization | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Necrosis | 2 |
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 |
Erosion | |
Mineralization | 4 4 3 |
Ulcer | |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 2 2 2 2 2 2|
Dilatation | |
Inflammation, Acute | |
Mineralization | 3 3 2 |
Mitral Valve, Inflammation, Chronic | |
Mitral Valve, Thrombosis | 4 |
Myocardium, Inflammation, Acute | 3 |
Myocardium, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Angiectasis | |
Vacuolization Cytoplasmic, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Bilateral, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 2|
DAY ON TEST | 7| 7| 6| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 3| 1| 0| 8| 5| 3| 1| 6| 5|
| 5| 5| 8| 9| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 4| 8| 8| 2| 9| 0| 2| 3| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.015 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia, Focal | 2 2 |
Hyperplasia, Focal, Squamous | 2 2 |
Inflammation, Chronic Active | 2 3 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Inflammation, Chronic Active | 2 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + M + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + +|
Hemorrhage | |
Hypospermia | 3 |
Mineralization | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Hemorrhage | 3 3 |
Hyperplasia | 2 |
Proliferation Connective Tissue | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 |
Mediastinal, Infiltration Cellular, | |
Polymorphonuclear | |
Mediastinal, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 3 3 |
Hyperplasia, Plasma Cell | 4 3 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 2|
DAY ON TEST | 7| 7| 6| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 3| 1| 0| 8| 5| 3| 1| 6| 5|
| 5| 5| 8| 9| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 4| 8| 8| 2| 9| 0| 2| 3| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.015 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | |
Hemorrhage | 2 |
Infiltration Cellular, | |
Polymorphonuclear | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + M + + +|
Congestion | 3 |
Depletion Lymphoid | 3 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 3 2 3 |
Hyperplasia, Focal, Re Cell | |
Necrosis | |
Necrosis, Multifocal | |
Capsule, Hematopoietic Cell | |
Proliferation | |
Red Pulp, Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | |
Depletion Lymphoid | 3 |
Ectopic Parathyroid Gland | |
Hemorrhage | |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + M + M + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Acanthosis | |
Erosion, Focal | |
Fibrosis, Focal | 3 |
Fibrosis, Multifocal | 4 |
Ulcer | 4 |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | 1 |
Hair Follicle, Hyperplasia, Basal | |
Cell, Multifocal | |
Sebaceous Gland, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
Cranium, Fibrous Osteodystrophy | 3 2 |
Sternum, Fibrous Osteodystrophy | 2 |
Sternum, Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 2|
DAY ON TEST | 7| 7| 6| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 3| 1| 0| 8| 5| 3| 1| 6| 5|
| 5| 5| 8| 9| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 4| 8| 8| 2| 9| 0| 2| 3| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.015 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Brain Stem, Inflammation, Acute | 1 |
Cerebellum, Necrosis | |
Cerebrum, Hemorrhage | |
Cerebrum, Necrosis, Focal | |
Thalamus, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Congestion | |
Granuloma | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Mineralization | 3 2 1 |
Necrosis, Focal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 3 3 |
Capillary, Thrombosis | |
Interstitium, Inflammation | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cataract | |
Cornea, Inflammation, Chronic Active | |
Cornea, Inflammation, Suppurative | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Focal, Glandular | 2 |
Hyperplasia, Focal, Squamous | 2 2 |
Hypertrophy | |
Inflammation, Chronic Active | |
Bilateral, Hyperplasia, Focal, | |
Squamous | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 2|
DAY ON TEST | 7| 7| 6| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 3| 1| 0| 8| 5| 3| 1| 6| 5|
| 5| 5| 8| 9| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 4| 8| 8| 2| 9| 0| 2| 3| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.015 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hydronephrosis | |
Inflammation, Acute | 2 2 |
Inflammation, Suppurative | |
Nephropathy | 4 3 2 4 3 4 4 3 4 4 4 4 4 2 3|
Renal Tubule, Hyperplasia, Focal | 2 |
Renal Tubule, Necrosis | |
Transitional Epithelium, Hyperplasia,| |
Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 2| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2|
DAY ON TEST | 5| 5| 3| 0| 8| 8| 2| 9| 8| 3| 5| 5| 0| 2| 0| 4| 4| 3| 0| 9| 7| 4| 3| 0| 9|
| 0| 2| 8| 8| 1| 4| 4| 6| 0| 8| 0| 2| 8| 6| 9| 8| 3| 8| 3| 0| 2| 3| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.015 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 1 2 2 2 |
Artery, Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 4 X 2 2 2 2 |
Degeneration, Cystic | 3 2 2 2 2 4 3 3 1 1 3 2 2 2 2 2 3 2 3 3 3 2 2 3|
Eosinophilic Focus | 3 3 3 3 2 4 3 2 3 3 2 2 2 2 3 2 3 3 3 2|
Fatty Change, Focal | |
Fatty Change, Multifocal | 1 1 |
Hematocyst | |
Hematopoietic Cell Proliferation | 1 1 1 1 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Acute, Multifocal | |
Inflammation, Granulomatous, | |
Multifocal | 1 |
Mixed Cell Focus | 3 2 2 2 2 3 1 3 2 2 3 3 2 2 |
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative, Multifocal | 2 |
Necrosis, Focal | 4|
Necrosis, Multifocal | |
Bile Duct, Hyperplasia, Focal, | |
Adenomatous | |
Bile Duct, Hyperplasia | 2 |
Caudate Lobe, Regeneration | |
Caudate Lobe, Periportal, Fibrosis | |
Centrilobular, Necrosis, Coagulative | 1 3 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Granulomatous | |
Artery, Mineralization | 4 3 |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 2| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2|
DAY ON TEST | 5| 5| 3| 0| 8| 8| 2| 9| 8| 3| 5| 5| 0| 2| 0| 4| 4| 3| 0| 9| 7| 4| 3| 0| 9|
| 0| 2| 8| 8| 1| 4| 4| 6| 0| 8| 0| 2| 8| 6| 9| 8| 3| 8| 3| 0| 2| 3| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.015 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Artery, Mineralization | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 1 1 1 1 1|
Erosion | 2 |
Mineralization | 4 3 3 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | + |
Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 2 1 2 2 2 2 2 2 |
Dilatation | |
Inflammation, Acute | 2 |
Mineralization | 3 3 |
Mitral Valve, Inflammation, Chronic | 2 |
Mitral Valve, Thrombosis | 3 |
Myocardium, Inflammation, Acute | |
Myocardium, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + M + + + + + +|
Angiectasis | |
Vacuolization Cytoplasmic, Focal | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + M + + + + + +|
Bilateral, Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 2| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2|
DAY ON TEST | 5| 5| 3| 0| 8| 8| 2| 9| 8| 3| 5| 5| 0| 2| 0| 4| 4| 3| 0| 9| 7| 4| 3| 0| 9|
| 0| 2| 8| 8| 1| 4| 4| 6| 0| 8| 0| 2| 8| 6| 9| 8| 3| 8| 3| 0| 2| 3| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.015 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Focal | 2 |
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic Active | 3 2 |
Duct, Ectasia | 2 2 3 2 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic Active | 1 2 3 4 2 3 2 3 |
Inflammation, Suppurative | 2 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hypospermia | 2 3 2 |
Mineralization | |
Interstitial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 |
Hemorrhage | 2 3 2 2 |
Hyperplasia | |
Proliferation Connective Tissue | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 3 3 |
Mediastinal, Infiltration Cellular, | |
Polymorphonuclear | 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 3 3 3 3 3 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + M +|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 2| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2|
DAY ON TEST | 5| 5| 3| 0| 8| 8| 2| 9| 8| 3| 5| 5| 0| 2| 0| 4| 4| 3| 0| 9| 7| 4| 3| 0| 9|
| 0| 2| 8| 8| 1| 4| 4| 6| 0| 8| 0| 2| 8| 6| 9| 8| 3| 8| 3| 0| 2| 3| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.015 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 2 |
Hemorrhage | |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + M + + + + M +|
Congestion | 2 2|
Depletion Lymphoid | 3 3 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Focal, Re Cell | 3 |
Necrosis | 3 |
Necrosis, Multifocal | |
Capsule, Hematopoietic Cell | |
Proliferation | 2 |
Red Pulp, Necrosis | |
__________________________________________________________________________|
Thymus | M M + M + + M + + + M M + + + + + + + + M + + M M|
Congestion | |
Cyst | |
Depletion Lymphoid | 3 |
Ectopic Parathyroid Gland | |
Hemorrhage | 2 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M M + + M + + + + + + + + + + M M + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Erosion, Focal | 3 |
Fibrosis, Focal | 3 |
Fibrosis, Multifocal | |
Ulcer | |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | |
Hair Follicle, Hyperplasia, Basal | |
Cell, Multifocal | |
Sebaceous Gland, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
Cranium, Fibrous Osteodystrophy | 3 3 3 |
Sternum, Fibrous Osteodystrophy | 3 2 |
Sternum, Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 2| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2|
DAY ON TEST | 5| 5| 3| 0| 8| 8| 2| 9| 8| 3| 5| 5| 0| 2| 0| 4| 4| 3| 0| 9| 7| 4| 3| 0| 9|
| 0| 2| 8| 8| 1| 4| 4| 6| 0| 8| 0| 2| 8| 6| 9| 8| 3| 8| 3| 0| 2| 3| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.015 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Inflammation, Acute | |
Cerebellum, Necrosis | |
Cerebrum, Hemorrhage | 3 2 |
Cerebrum, Necrosis, Focal | 3 |
Thalamus, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Granuloma | 1 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 |
Mineralization | |
Necrosis, Focal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 2 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 2 2 |
Capillary, Thrombosis | |
Interstitium, Inflammation | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 |
Cornea, Inflammation, Chronic Active | |
Cornea, Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 4 3 |
Hyperplasia, Focal, Glandular | |
Hyperplasia, Focal, Squamous | 2 3 3 |
Hypertrophy | |
Inflammation, Chronic Active | 3 2 |
Bilateral, Hyperplasia, Focal, | |
Squamous | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 2| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2|
DAY ON TEST | 5| 5| 3| 0| 8| 8| 2| 9| 8| 3| 5| 5| 0| 2| 0| 4| 4| 3| 0| 9| 7| 4| 3| 0| 9|
| 0| 2| 8| 8| 1| 4| 4| 6| 0| 8| 0| 2| 8| 6| 9| 8| 3| 8| 3| 0| 2| 3| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.015 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hydronephrosis | 2 |
Inflammation, Acute | |
Inflammation, Suppurative | 3 |
Nephropathy | 4 4 4 4 3 4 3 3 3 4 4 4 3 3 2 4 3 4 3 4 4 3 3 4|
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Necrosis | |
Transitional Epithelium, Hyperplasia,| |
Multifocal | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| | |
DAY ON TEST | 2| 0| 8| 6| 6| 7| 5| 5| 3| 2| 7| 5| 5| 4| 2| 8| 3| 0| 8| 1| | |
| 8| 9| 0| 5| 4| 2| 2| 2| 8| 4| 2| 2| 2| 9| 4| 3| 8| 6| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.015 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + A + + + | 58 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + | 58 |
Parasite Metazoan | X 2 | 9 1.9|
Artery, Inflammation, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 60 |
Parasite Metazoan | 2 3 | 5 1.8|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + M + + A A + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + M + + A A + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + M + + A A + + | 54 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + M + + A A + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 60 |
Angiectasis | 3 2 | 3 2.3|
Basophilic Focus | 2 3 2 2 2 2 X 2 X 2 2 2 2 | 27 2.0|
Degeneration, Cystic | 2 1 2 1 1 2 2 2 3 3 2 4 3 3 2 2 2 3 | 51 2.3|
Eosinophilic Focus | 3 2 3 2 3 3 3 3 3 3 3 3 4 3 3 3 3 2 2 3 | 53 2.6|
Fatty Change, Focal | 1 | 1 1.0|
Fatty Change, Multifocal | 2 1 1 1 | 6 1.2|
Hematocyst | X | 1 |
Hematopoietic Cell Proliferation | 1 2 1 1 | 15 1.1|
Hepatodiaphragmatic Nodule | X X | 6 |
Inflammation, Acute, Multifocal | | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | | 2 1.0|
Mixed Cell Focus | 3 3 3 3 3 1 2 2 | 30 2.2|
Necrosis, Coagulative, Focal | 2 | 1 2.0|
Necrosis, Coagulative, Multifocal | | 2 2.5|
Necrosis, Focal | | 1 4.0|
Necrosis, Multifocal | 2 | 1 2.0|
Bile Duct, Hyperplasia, Focal, | | |
Adenomatous | 2 | 1 2.0|
Bile Duct, Hyperplasia | | 1 2.0|
Caudate Lobe, Regeneration | | 1 3.0|
Caudate Lobe, Periportal, Fibrosis | | 1 3.0|
Centrilobular, Necrosis, Coagulative | | 5 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| | |
DAY ON TEST | 2| 0| 8| 6| 6| 7| 5| 5| 3| 2| 7| 5| 5| 4| 2| 8| 3| 0| 8| 1| | |
| 8| 9| 0| 5| 4| 2| 2| 2| 8| 4| 2| 2| 2| 9| 4| 3| 8| 6| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.015 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mesentery | + | 7 |
Inflammation, Granulomatous | 1 | 1 1.0|
Artery, Mineralization | | 5 3.2|
Fat, Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + M + + + + + + | 57 |
Artery, Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | + | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 60 |
Necrosis | | 1 2.0|
Acinus, Atrophy | | 2 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + M + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + M + + + + + + | 59 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + M + + + + + + | 59 |
Degeneration, Cystic | 1 1 1 1 | 15 1.1|
Erosion | | 1 2.0|
Mineralization | 3 3 | 8 3.4|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + | 3 |
Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 59 |
Cardiomyopathy | 2 2 2 2 2 1 2 | 31 1.9|
Dilatation | 3 | 1 3.0|
Inflammation, Acute | | 1 2.0|
Mineralization | 3 | 6 2.8|
Mitral Valve, Inflammation, Chronic | | 1 2.0|
Mitral Valve, Thrombosis | | 2 3.5|
Myocardium, Inflammation, Acute | | 1 3.0|
Myocardium, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 59 |
Angiectasis | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 1 | 5 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| | |
DAY ON TEST | 2| 0| 8| 6| 6| 7| 5| 5| 3| 2| 7| 5| 5| 4| 2| 8| 3| 0| 8| 1| | |
| 8| 9| 0| 5| 4| 2| 2| 2| 8| 4| 2| 2| 2| 9| 4| 3| 8| 6| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.015 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Bilateral, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + | 57 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 58 |
Hyperplasia | 3 2 3 3 | 11 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Ultimobranchial Cyst | X X | 7 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
Mineralization | 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
Hyperplasia, Focal | | 3 2.0|
Hyperplasia, Focal, Squamous | | 2 2.0|
Inflammation, Chronic Active | 2 2 2 2 | 8 2.3|
Duct, Ectasia | 3 3 2 1 3 | 13 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Focal | 2 | 3 2.0|
Inflammation, Chronic Active | 1 2 2 2 2 | 15 2.2|
Inflammation, Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + M + + + + + + + + + + + + + + + + | 58 |
Atrophy | 3 2 | 5 2.4|
Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 60 |
Hemorrhage | 2 | 1 2.0|
Hypospermia | 2 2 | 6 2.3|
Mineralization | 1 | 1 1.0|
Interstitial Cell, Hyperplasia | 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 60 |
Atrophy | 3 2 | 8 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| | |
DAY ON TEST | 2| 0| 8| 6| 6| 7| 5| 5| 3| 2| 7| 5| 5| 4| 2| 8| 3| 0| 8| 1| | |
| 8| 9| 0| 5| 4| 2| 2| 2| 8| 4| 2| 2| 2| 9| 4| 3| 8| 6| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.015 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | 3 3 | 8 2.6|
Hyperplasia | 2 2 | 3 2.0|
Proliferation Connective Tissue | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 60 |
Mediastinal, Hemorrhage | 3 2 3 3 | 7 2.7|
Mediastinal, Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 60 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 3 3.0|
Hyperplasia, Plasma Cell | 3 3 2 3 3 2 2 4 | 16 2.9|
Sinus, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + | 56 |
Atrophy | | 1 2.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + M + + M + + + | 55 |
Congestion | | 3 2.3|
Depletion Lymphoid | | 3 3.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 3 4 2 | 11 2.9|
Hyperplasia, Focal, Re Cell | | 1 3.0|
Necrosis | 3 | 2 3.0|
Necrosis, Multifocal | 2 | 1 2.0|
Capsule, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Red Pulp, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + M + + + M + + + | 48 |
Congestion | | 1 3.0|
Cyst | X | 1 |
Depletion Lymphoid | 3 | 3 3.0|
Ectopic Parathyroid Gland | X | 1 |
Hemorrhage | 2 | 2 2.0|
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| | |
DAY ON TEST | 2| 0| 8| 6| 6| 7| 5| 5| 3| 2| 7| 5| 5| 4| 2| 8| 3| 0| 8| 1| | |
| 8| 9| 0| 5| 4| 2| 2| 2| 8| 4| 2| 2| 2| 9| 4| 3| 8| 6| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.015 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M M + M + + + + + + | 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 60 |
Acanthosis | | 1 3.0|
Erosion, Focal | | 1 3.0|
Fibrosis, Focal | | 2 3.0|
Fibrosis, Multifocal | | 1 4.0|
Ulcer | | 1 4.0|
Hair Follicle, Hyperplasia, Basal | | |
Cell, Focal | | 1 1.0|
Hair Follicle, Hyperplasia, Basal | | |
Cell, Multifocal | 2 | 1 2.0|
Sebaceous Gland, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 5 |
Cranium, Fibrous Osteodystrophy | | 5 2.8|
Sternum, Fibrous Osteodystrophy | | 3 2.3|
Sternum, Osteopetrosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 60 |
Brain Stem, Inflammation, Acute | | 1 1.0|
Cerebellum, Necrosis | 4 | 1 4.0|
Cerebrum, Hemorrhage | | 2 2.5|
Cerebrum, Necrosis, Focal | | 1 3.0|
Thalamus, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 60 |
Congestion | | 1 4.0|
Granuloma | | 1 1.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 | 13 1.0|
Mineralization | 3 | 4 2.3|
Necrosis, Focal | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 8 1.6|
Alveolar Epithelium, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05166-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE Date: 04/29/97
Route: DOSED WATER Time: 17:28:43
__________________________________________________________________________________________________________________________________
| 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| | |
DAY ON TEST | 2| 0| 8| 6| 6| 7| 5| 5| 3| 2| 7| 5| 5| 4| 2| 8| 3| 0| 8| 1| | |
| 8| 9| 0| 5| 4| 2| 2| 2| 8| 4| 2| 2| 2| 9| 4| 3| 8| 6| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.015 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Multifocal | 2 2 2 | 9 2.2|
Capillary, Thrombosis | 3 | 1 3.0|
Interstitium, Inflammation | 1 | 4 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + | 4 |
Cataract | | 1 3.0|
Cornea, Inflammation, Chronic Active | 3 | 1 3.0|
Cornea, Inflammation, Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + | 59 |
Ectasia | 3 2 | 5 3.0|
Hyperplasia, Focal, Glandular | | 1 2.0|
Hyperplasia, Focal, Squamous | 3 2 | 7 2.4|
Hypertrophy | 3 | 1 3.0|
Inflammation, Chronic Active | | 2 2.5|
Bilateral, Hyperplasia, Focal, | | |
Squamous | | 3 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 59 |
Cyst | X | 1 |
Hydronephrosis | | 1 2.0|
Inflammation, Acute | | 2 2.0|
Inflammation, Suppurative | | 1 3.0|
Nephropathy | 3 3 3 3 2 4 3 4 4 3 4 4 4 4 2 3 4 4 3 1 | 59 3.4|
Renal Tubule, Hyperplasia, Focal | | 1 2.0|
Renal Tubule, Necrosis | 4 | 1 4.0|
Transitional Epithelium, Hyperplasia,| | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + | 59 |
Dilatation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 903163-903163/903163
--multipart-boundary--