TDMS Study 05166-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: HLA, VA DATE: 09/18/94
EXP: 05166 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE TIME: 01:07:11
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP C#: 99990
CONT: NO1ES9565503 CAS: 612-82-8
PATHOLOGIST: G. PARKER S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: HLA, VA DATE: 09/18/94
EXP: 05166 3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE TIME: 01:07:11
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP C#: 99990
CONT: NO1ES9565503 CAS: 612-82-8
PATHOLOGIST: G. PARKER S. EUSTIS
3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 419 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 60 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 275 275 275 275 275 275 275 275 275 275 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.003 |
| --------------------- |
| |
| TOTAL 45 UNCENSORED DEATHS 4 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 250 359 391 405 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.007 |
| --------------------- |
| |
| TOTAL 75 UNCENSORED DEATHS 24 CENSORED DEATHS 1 TERMINAL 50 |
| |
| UNCENSORED DEATHS |
| 215 229 285 285 285 295 307 341 343 355 |
| 372 378 379 379 384 384 391 393 404 405 |
| 405 406 406 406 |
| CENSORED DEATHS |
| 12 |
| |
==================================================================================
3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 419 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.015 |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 60 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 209 211 211 226 229 238 254 264 264 265 |
| 268 280 280 280 280 281 290 296 296 303 |
| 305 306 308 308 309 309 310 312 324 324 |
| 324 328 333 338 338 338 338 338 338 338 |
| 343 343 344 348 349 350 350 352 352 352 |
| 352 352 352 352 372 372 372 379 383 384 |
| CENSORED DEATHS |
| 275 275 275 275 275 275 275 275 275 275 |
| |
==================================================================================
3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 419 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 419 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
| | |
| | |
|0.003 | 100.0 100.0 97.8 95.6 91.1 91.1 91.1 91.1 91.1 91.1 |
| | |
| | |
|0.007 | 100.0 100.0 97.3 86.5 67.6 67.6 67.6 67.6 67.6 67.6 |
| | |
| | |
|0.015 | 100.0 100.0 84.3 10.3 0.0 0.0 0.0 0.0 0.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.003 0.007 0.015 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 100.0% 91.1% 67.6% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.059 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | . 351.3 351.3 314.1 |
|NATURAL DEATHS (C) | ( . ) (35.1) (11.9) ( 5.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 398.4 413.0 391.9 308.5 |
|(STANDARD ERROR) | ( 6.1) ( 4.0) ( 7.3) ( 5.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 421 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 1 CENSORED DEATHS 10 TERMINAL 59 |
| |
| UNCENSORED DEATHS |
| 390 |
| CENSORED DEATHS |
| 275 275 275 275 275 275 275 275 275 275 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.003 |
| --------------------- |
| |
| TOTAL 45 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 357 384 391 391 391 393 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.007 |
| --------------------- |
| |
| TOTAL 75 UNCENSORED DEATHS 43 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 142 184 229 268 309 310 315 315 315 320 |
| 327 338 338 338 338 338 355 363 364 365 |
| 369 369 370 378 379 383 384 388 390 390 |
| 391 391 391 405 405 405 406 406 406 406 |
| 406 409 419 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 421 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.015 |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 50 CENSORED DEATHS 10 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 142 229 247 251 254 264 264 265 280 285 |
| 285 295 296 296 315 315 335 335 336 338 |
| 338 338 341 341 343 343 343 355 355 364 |
| 370 370 377 378 383 383 384 384 390 391 |
| 391 391 391 391 405 405 405 406 406 406 |
| CENSORED DEATHS |
| 275 275 275 275 275 275 275 275 275 275 |
| |
==================================================================================
3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 421 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 421 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.3 98.3 98.3 98.3 98.3 98.3 |
| | |
| | |
|0.003 | 100.0 100.0 100.0 97.8 86.7 86.7 86.7 86.7 86.7 86.7 |
| | |
| | |
|0.007 | 100.0 98.7 94.7 73.3 42.7 42.7 42.7 42.7 42.7 42.7 |
| | |
| | |
|0.015 | 100.0 98.6 88.6 51.1 17.0 17.0 17.0 17.0 17.0 17.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.003 0.007 0.015 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 98.3% 86.7% 42.7% 17.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.049 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 390.0 384.5 353.9 337.9 |
|NATURAL DEATHS (C) | ( . ) ( 5.6) ( 9.1) ( 8.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 399.7 416.1 382.5 340.8 |
|(STANDARD ERROR) | ( 6.1) ( 2.0) ( 6.5) ( 7.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.003 = 2
0.007 = 3
0.015 = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 4 3 2 1
| 4 3 3 2 3 2
| 4 4 2 2
| 4 4 4 3 3 3 2 2
90 + 4 4 3 3 2 2
| 3 3 3
| 4 4 4 3 3
|
80 +
| 4 4 3 3 3
| 4 4 4 3 3
|
P 70 + 4 4
E | 3 3
R |
C | 4 4
E 60 +
N |
T | 4 4
|
S 50 +
U | 4 4 4
R |
V |
I 40 +
V |
A |
L |
30 + 4 4
|
|
| 4 4
20 +
|
|
|
10 + 4 4
|
| 4 4
|
0 + 4
|
---+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+--
0 5 10 15 20 25 30 35 40 45 50 55 60
WEEK
NOTE: 12 obs hidden.
3,3-DIMETHYLBENZIDINE DIHYDROCHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.003 = 2
0.007 = 3
0.015 = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
| 3 3 3 4 2 21 1
| 3 4 4 3 3 22
| 44
90 + 2 2
| 4 44 3 33 2 2
| 3 3
| 4 4
80 +
| 4 4 3 3 3
P | 4 4 33
E |
R 70 + 4 4 3 3
C | 3 3
E | 33
N |
T 60 +
|
S | 4 4 3 3
U | 4 4
R 50 + 44
V | 4 4
I | 4 4 33 3
V | 3 3
A 40 +
L | 44
|
|
30 +
| 4 4
|
|
20 +
| 4 4
|
|
10 +
|
---+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+--
0 3 6 9 12 15 18 21 24 27 30 33 36 39 42 45 48 51 54 57 60 63
WEEK
NOTE: 13 obs hidden.
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