TDMS Study 05169-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
C. I. DIRECT BLUE 15
NTP Experiment-Test: 05169-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/18/94
Route: DOSED WATER Time: 03:28:37
Facility: Hazleton Laboratories America, Inc.
Chemical CAS #: 2429-74-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05169-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 09/18/94
Route: DOSED WATER Time: 03:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.063 0.125 0.25
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 45 75 70
Scheduled Sacrifice 20 10 10 20
Early Deaths
Dead 4 4 12 15
Moribund 6 18 31 31
Survivors
Terminal Sacrifice 40 13 22 4
Animals Examined Microscopically 50 35 65 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (35) (65) (50)
Polyp Adenomatous 2 (3%)
Ascending Colon, Polyp Adenomatous 1 (2%)
Descending Colon, Polyp Adenomatous 1 (2%)
Intestine Small, Duodenum (50) (35) (64) (50)
Adenocarcinoma, Cystic, Mucinous 1 (2%)
Intestine Small, Jejunum (50) (35) (64) (50)
Adenocarcinoma 1 (2%)
Adenocarcinoma, Cystic, Mucinous 2 (4%)
Liver (50) (35) (65) (50)
Hepatocellular Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Neoplastic Nodule 2 (3%) 4 (8%)
Mesentery (4) (5) (7) (4)
Adenocarcinoma, Metastatic, Uterus 1 (25%)
Pancreas (49) (35) (65) (49)
Pharynx (4) (21) (12)
Palate, Squamous Cell Carcinoma 5 (24%) 3 (25%)
Palate, Squamous Cell Papilloma 2 (50%) 10 (48%) 7 (58%)
Palate, Squamous Cell Papilloma, Multiple 1 (5%)
Salivary Glands (50) (35) (65) (50)
Sarcoma 1 (2%)
Stomach, Forestomach (50) (35) (65) (50)
Stomach, Glandular (50) (35) (65) (50)
Tongue (2) (3) (6) (9)
Squamous Cell Carcinoma 1 (33%) 3 (50%) 3 (33%)
Squamous Cell Papilloma 2 (100%) 1 (33%) 1 (17%) 4 (44%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05169-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 09/18/94
Route: DOSED WATER Time: 03:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.063 0.125 0.25
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (35) (65) (50)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (35) (65) (50)
Adrenal Gland, Medulla (50) (35) (65) (50)
Pheochromocytoma Benign 3 (6%) 2 (6%) 7 (11%) 1 (2%)
Bilateral, Pheochromocytoma Benign 1 (2%) 2 (6%)
Islets, Pancreatic (50) (35) (65) (50)
Carcinoma 1 (2%)
Pituitary Gland (49) (35) (65) (49)
Pars Distalis, Adenoma 18 (37%) 10 (29%) 19 (29%) 6 (12%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (49) (35) (65) (50)
Bilateral, Follicular Cell, Adenoma 1 (3%)
C-Cell, Adenoma 10 (20%) 3 (9%) 4 (6%)
C-Cell, Carcinoma 3 (6%) 3 (5%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (31) (64) (50)
Adenoma 5 (10%) 4 (13%) 9 (14%) 8 (16%)
Carcinoma 1 (2%) 4 (13%) 10 (16%) 9 (18%)
Bilateral, Adenoma 1 (3%) 3 (5%) 4 (8%)
Bilateral, Carcinoma 1 (2%) 2 (6%) 2 (3%) 6 (12%)
Ovary (50) (35) (64) (50)
Adenoma 1 (3%)
Granulosa Cell Tumor Benign 1 (2%)
Granulosa-Theca Tumor Benign 1 (2%)
Histiocytic Sarcoma 1 (2%)
Uterus (50) (35) (65) (50)
Adenocarcinoma 1 (2%) 3 (6%)
Adenoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 4 (8%) 7 (20%) 9 (14%) 5 (10%)
Polyp Stromal, Multiple 1 (2%) 1 (3%) 3 (5%)
Page 3
NTP Experiment-Test: 05169-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 09/18/94
Route: DOSED WATER Time: 03:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.063 0.125 0.25
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Sarcoma Stromal 1 (2%) 1 (2%) 2 (4%)
Cervix, Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Vagina (2) (1) (1) (1)
Sarcoma Stromal, Multiple, Metastatic, Uterus 1 (100%)
Squamous Cell Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (35) (64) (49)
Lymph Node (50) (35) (65) (50)
Iliac, Carcinoma, Metastatic, Clitoral Gland 1 (2%)
Iliac, Histiocytic Sarcoma 1 (2%)
Lumbar, Histiocytic Sarcoma 1 (2%)
Mediastinal, Histiocytic Sarcoma 1 (2%)
Pancreatic, Histiocytic Sarcoma 1 (2%)
Renal, Histiocytic Sarcoma 1 (2%)
Lymph Node, Mandibular (50) (33) (65) (50)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Carcinoma, Metastatic,
Uncertain Primary Site 1 (3%)
Lymph Node, Mesenteric (50) (34) (65) (50)
Histiocytic Sarcoma 1 (2%)
Renal, Mediastinal, Pancreatic, Mandibular,
Leukemia Mononuclear 1 (3%)
Spleen (50) (35) (65) (50)
Histiocytic Sarcoma 1 (2%)
Sarcoma 1 (2%)
Thymus (47) (31) (63) (45)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (34) (63) (44)
Adenocarcinoma 4 (8%) 3 (9%) 2 (3%) 2 (5%)
Fibroadenoma 12 (24%) 2 (6%) 10 (16%) 2 (5%)
Fibroadenoma, Multiple 4 (8%) 2 (6%) 6 (10%) 2 (5%)
Skin (49) (34) (65) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 2 (4%) 1 (3%) 3 (5%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (6%) 5 (8%) 5 (10%)
Sebaceous Gland, Carcinoma 1 (3%)
Subcutaneous Tissue, Fibroma 3 (6%)
Subcutaneous Tissue, Neurofibroma 1 (3%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%)
Page 4
NTP Experiment-Test: 05169-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 09/18/94
Route: DOSED WATER Time: 03:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.063 0.125 0.25
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (13) (4) (12) (7)
Cranium, Carcinoma, Metastatic, Zymbal's
Gland 1 (8%) 1 (14%)
Tibia, Osteosarcoma 1 (8%)
Skeletal Muscle (2) (1)
Back, Carcinoma, Metastatic, Clitoral Gland 1 (50%)
Cervical, Carcinoma, Metastatic, Zymbal's
Gland 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (35) (65) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Cerebrum, Astrocytoma Malignant 1 (2%) 2 (3%) 1 (2%)
Cranial Nerve, Carcinoma, Metastatic,
Zymbal's Gland 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (35) (65) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (6%) 1 (2%)
Carcinoma, Metastatic 1 (3%)
Carcinoma, Metastatic, Clitoral Gland 2 (6%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Multiple, Metastatic, Bone 1 (2%)
Squamous Cell Carcinoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Carcinoma, Metastatic, Zymbal's Gland 1 (100%)
Zymbal's Gland (49) (35) (64) (50)
Adenoma 1 (3%) 5 (8%) 3 (6%)
Carcinoma 4 (11%) 7 (11%) 14 (28%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05169-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 09/18/94
Route: DOSED WATER Time: 03:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.063 0.125 0.25
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (35) (65) (50)
Histiocytic Sarcoma 1 (2%)
Ureter (1)
Transitional Epithelium, Papilloma 1 (100%)
Urinary Bladder (50) (35) (65) (50)
Histiocytic Sarcoma 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(35) *(65) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 7 (14%) 13 (37%) 27 (42%) 15 (30%)
Mesothelioma Malignant 1 (3%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05169-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 09/18/94
Route: DOSED WATER Time: 03:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.063 0.125 0.25
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 43 33 64 49
Total Primary Neoplasms 91 75 175 117
Total Animals with Benign Neoplasms 38 27 54 33
Total Benign Neoplasms 68 46 105 53
Total Animals with Malignant Neoplasms 21 24 56 48
Total Malignant Neoplasms 23 29 70 64
Total Animals with Metastatic Neoplasms 1 4 4 5
Total Metastatic Neoplasm 1 4 4 9
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05169-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 09/18/94
Route: DOSED WATER Time: 03:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.063 0.125 0.25
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 45 75 70
Scheduled Sacrifice 20 10 10 20
Early Deaths
Dead 5 12 24 12
Moribund 8 15 30 34
Accident 2
Survivors
Terminal Sacrifice 37 8 11 2
Animals Examined Microscopically 50 35 65 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (35) (61) (50)
Intestine Large, Colon (50) (35) (62) (50)
Adenocarcinoma 4 (6%) 3 (6%)
Polyp Adenomatous 1 (2%) 1 (2%)
Ascending Colon, Polyp Adenomatous 1 (3%)
Descending Colon, Polyp Adenomatous 1 (2%) 4 (8%)
Intestine Small, Duodenum (49) (35) (60) (50)
Adenocarcinoma, Cystic, Mucinous 1 (2%)
Intestine Small, Ileum (49) (35) (60) (50)
Intestine Small, Jejunum (49) (35) (60) (50)
Adenocarcinoma 1 (2%)
Adenocarcinoma, Cystic, Mucinous 1 (2%)
Carcinoma, Metastatic 1 (3%)
Polyp Adenomatous 1 (3%)
Liver (50) (35) (65) (50)
Carcinoma, Metastatic 1 (3%)
Hepatocellular Carcinoma 1 (2%) 4 (8%)
Neoplastic Nodule 5 (14%) 7 (11%) 4 (8%)
Neoplastic Nodule, Multiple 1 (3%) 1 (2%) 3 (6%)
Mesentery (8) (6) (11) (6)
Carcinoma, Metastatic 1 (17%)
Sarcoma 1 (9%)
Pancreas (49) (35) (65) (50)
Pharynx (1) (9) (23) (20)
Squamous Cell Carcinoma 1 (4%)
Palate, Squamous Cell Carcinoma 1 (100%) 3 (13%) 2 (10%)
Palate, Squamous Cell Papilloma 9 (100%) 16 (70%) 15 (75%)
Palate, Squamous Cell Papilloma, Multiple 1 (4%)
Salivary Glands (50) (35) (65) (50)
Schwannoma Malignant 2 (3%)
Page 8
NTP Experiment-Test: 05169-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 09/18/94
Route: DOSED WATER Time: 03:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.063 0.125 0.25
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Bilateral, Schwannoma Malignant 1 (2%)
Stomach, Forestomach (49) (35) (65) (50)
Carcinoma, Metastatic 1 (3%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (49) (34) (65) (50)
Tongue (2) (4) (2)
Squamous Cell Carcinoma 1 (50%) 2 (50%)
Squamous Cell Papilloma 1 (25%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (35) (65) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (35) (65) (50)
Adrenal Gland, Medulla (50) (35) (65) (50)
Pheochromocytoma Malignant 2 (3%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 12 (24%) 3 (9%) 10 (15%) 14 (28%)
Bilateral, Pheochromocytoma Benign 4 (8%) 2 (6%) 9 (14%) 3 (6%)
Islets, Pancreatic (50) (35) (65) (50)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (49) (34) (63) (50)
Pars Distalis, Adenoma 5 (10%) 1 (3%) 3 (5%) 3 (6%)
Thyroid Gland (50) (35) (65) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
Bilateral, C-Cell, Carcinoma 1 (2%) 1 (2%)
C-Cell, Adenoma 5 (10%) 8 (23%) 6 (9%) 4 (8%)
C-Cell, Carcinoma 2 (4%) 1 (3%) 1 (2%) 1 (2%)
Follicular Cell, Adenoma 4 (11%) 1 (2%)
Follicular Cell, Carcinoma 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05169-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 09/18/94
Route: DOSED WATER Time: 03:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.063 0.125 0.25
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (35) (64) (50)
Carcinoma, Multiple, Metastatic 1 (3%)
Preputial Gland (49) (35) (64) (48)
Adenoma 5 (10%) 1 (3%) 10 (16%) 8 (17%)
Carcinoma 2 (4%) 2 (6%) 10 (16%) 1 (2%)
Bilateral, Adenoma 1 (2%) 1 (3%) 2 (3%)
Bilateral, Carcinoma 1 (3%) 1 (2%)
Prostate (50) (35) (64) (49)
Adenoma 1 (2%)
Schwannoma Malignant 1 (2%)
Seminal Vesicle (47) (32) (57) (42)
Carcinoma, Metastatic 1 (3%)
Schwannoma Malignant, Metastatic, Prostate 1 (2%)
Testes (50) (35) (65) (50)
Carcinoma, Metastatic 1 (3%)
Bilateral, Interstitial Cell, Adenoma 43 (86%) 29 (83%) 52 (80%) 33 (66%)
Interstitial Cell, Adenoma 5 (10%) 3 (9%) 9 (14%) 10 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (35) (63) (50)
Lymph Node (50) (35) (64) (50)
Axillary, Carcinoma, Metastatic 1 (2%)
Axillary, Squamous Cell Carcinoma,
Metastatic, Skin 1 (2%)
Mediastinal, Squamous Cell Carcinoma,
Metastatic 1 (2%)
Lymph Node, Mandibular (50) (35) (62) (50)
Squamous Cell Carcinoma, Metastatic, Tongue 1 (2%)
Mediastinal, Carcinoma, Multiple, Metastatic,
Zymbal's Gland 1 (2%)
Lymph Node, Mesenteric (50) (35) (64) (50)
Carcinoma, Metastatic 1 (3%)
Spleen (50) (35) (64) (50)
Carcinoma, Metastatic 1 (3%)
Thymus (43) (34) (51) (43)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (34) (59) (42)
Fibroadenoma 1 (2%)
Skin (50) (35) (65) (50)
Basal Cell Adenoma 2 (4%) 5 (14%) 15 (23%) 9 (18%)
Page 10
NTP Experiment-Test: 05169-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 09/18/94
Route: DOSED WATER Time: 03:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.063 0.125 0.25
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Basal Cell Adenoma, Multiple 3 (9%) 8 (12%) 17 (34%)
Basal Cell Carcinoma 2 (6%) 3 (5%) 10 (20%)
Basal Cell Carcinoma, Multiple 1 (2%)
Carcinoma 1 (2%)
Keratoacanthoma 2 (4%) 1 (3%) 7 (11%) 2 (4%)
Squamous Cell Carcinoma 1 (3%) 7 (11%) 7 (14%)
Squamous Cell Carcinoma, Multiple 6 (12%)
Squamous Cell Papilloma 2 (4%) 3 (9%) 3 (5%) 7 (14%)
Squamous Cell Papilloma, Multiple 2 (3%) 1 (2%)
Sebaceous Gland, Adenoma 1 (3%) 6 (9%) 3 (6%)
Sebaceous Gland, Adenoma, Multiple 1 (2%)
Subcutaneous Tissue, Carcinoma, Metastatic,
Zymbal's Gland 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 2 (6%) 5 (8%) 3 (6%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (1) (1) (1)
Cranium, Carcinoma, Metastatic, Zymbal's
Gland 1 (100%)
Vertebra, Osteoma 1 (100%)
Skeletal Muscle (1)
Back, Schwannoma Malignant, Metastatic,
Spinal Cord 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (35) (65) (50)
Cerebrum, Astrocytoma Malignant 1 (3%) 1 (2%) 1 (2%)
Medulla, Astrocytoma Malignant 1 (2%)
Spinal Cord (1)
Nerve, Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (35) (65) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (3%) 4 (6%) 1 (2%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Carcinoma, Multiple, Metastatic, Zymbal's
Gland 1 (3%) 1 (2%) 1 (2%)
Carcinoma, Metastatic 1 (3%)
Page 11
NTP Experiment-Test: 05169-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 09/18/94
Route: DOSED WATER Time: 03:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.063 0.125 0.25
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Carcinoma, Metastatic, Thyroid Gland 1 (3%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Neoplasm NOS, Metastatic, Uncertain Primary
Site 1 (2%)
Neurofibrosarcoma, Multiple, Metastatic, Skin 1 (2%)
Squamous Cell Carcinoma, Multiple,
Metastatic, Skin 1 (2%) 2 (4%)
Squamous Cell Carcinoma, Metastatic 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Nose (50) (35) (65) (49)
Squamous Cell Carcinoma 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (50) (35) (64) (50)
Adenoma 2 (6%) 2 (3%) 4 (8%)
Carcinoma 1 (2%) 3 (9%) 8 (13%) 17 (34%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (35) (65) (50)
Carcinoma, Metastatic 1 (3%)
Renal Tubule, Adenoma 2 (4%)
Urinary Bladder (50) (35) (65) (50)
Carcinoma, Metastatic 1 (3%)
Schwannoma Malignant, Metastatic, Prostate 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(35) *(65) *(50)
Leukemia Mononuclear 17 (34%) 19 (54%) 28 (43%) 20 (40%)
Mesothelioma Malignant 1 (2%) 3 (9%) 2 (3%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 05169-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. DIRECT BLUE 15 Date: 09/18/94
Route: DOSED WATER Time: 03:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.063 0.125 0.25
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 34 65 48
Total Primary Neoplasms 116 125 276 236
Total Animals with Benign Neoplasms 48 33 62 46
Total Benign Neoplasms 91 88 188 153
Total Animals with Malignant Neoplasms 23 27 54 45
Total Malignant Neoplasms 25 37 88 83
Total Animals with Metastatic Neoplasms 1 5 8 9
Total Metastatic Neoplasm 2 26 12 15
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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